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2021

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Keeping Great Marsh Great, Robbin Ray Dec 2021

Keeping Great Marsh Great, Robbin Ray

UNH Today Archive

No abstract provided.


One Story, Two Authors And Seven Layers, Edwin B. Smith Dec 2021

One Story, Two Authors And Seven Layers, Edwin B. Smith

University of Mississippi News

Gregg Davidson's 'The Manifold Beauty of Genesis One' melds scholarship with faith


Investigation Of Pharmacokinetic Parameters Of Trelagliptin In Egyptian Volunteers Using Sensitive Lc-Ms/Ms: A Comparative Study With A Japanese Population, Shereen Mowaka, Nermeen Ashoush, Mariam M. Tadros, Bassam Ayoub Dec 2021

Investigation Of Pharmacokinetic Parameters Of Trelagliptin In Egyptian Volunteers Using Sensitive Lc-Ms/Ms: A Comparative Study With A Japanese Population, Shereen Mowaka, Nermeen Ashoush, Mariam M. Tadros, Bassam Ayoub

Pharmacy

Trelagliptin (TLN) is a novel once-weekly antidiabetic drug that enhanced the patient compliance in type 2 diabetes. TLN analysis and bioanalysis literature review showed many methods for TLN assay either in dosage form or as biological fluids (pharmacokinetic parameters), but all those methods did not consider the full details dealing with biological assay of TLN. Studies that included information about pharmacokinetic parameters did notmentionthe usedanalytical proceduresfor those determinations and parameters. Although some LC-MS/MS and UPLC-UV methods were reported for TLN bioassay in rats’ plasma, they used direct precipitation techniques, and the current described procedure showed lower LLOQ than all the …


Functional Differentiation In The Language Network Revealed By Lesion-Dymptom Mapping, William Matchin, Alexandra Basilakos, Dirk B. Den Ouden, Brielle C. Stark, Gregory Hickok, Julius Fridriksson Dec 2021

Functional Differentiation In The Language Network Revealed By Lesion-Dymptom Mapping, William Matchin, Alexandra Basilakos, Dirk B. Den Ouden, Brielle C. Stark, Gregory Hickok, Julius Fridriksson

Communication Sciences and Disorders Faculty Articles and Research

Theories of language organization in the brain commonly posit that different regions underlie distinct linguistic mechanisms. However, such theories have been criticized on the grounds that many neuroimaging studies of language processing find similar effects across regions. Moreover, condition by region interaction effects, which provide the strongest evidence of functional differentiation between regions, have rarely been offered in support of these theories. Here we address this by using lesion-symptom mapping in three large, partially-overlapping groups of aphasia patients with left hemisphere brain damage due to stroke (N = 121, N = 92, N = 218). We identified multiple measure by …


Motivation To Move Out Of The Community As A Moderator Of Bullying Victimization And Delinquent Behavior: Comparing Non-Heterosexual/Cisgender And Heterosexual African American Adolescents In Chicago’S Southside, Dexter R. Voisin Dec 2021

Motivation To Move Out Of The Community As A Moderator Of Bullying Victimization And Delinquent Behavior: Comparing Non-Heterosexual/Cisgender And Heterosexual African American Adolescents In Chicago’S Southside, Dexter R. Voisin

Faculty Scholarship

A growing body of research documents that bullying victimization is associated with delinquent behavior. There is an increasing need to better illuminate the factors that might moderate this relationship. This study examined whether the motivation to move out of low-resourced neighborhoods and sexual orientation/gender identity moderated the relationship between bullying victimization and delinquent behavior among a sample of 450 heterosexual and 91 non-heterosexual/cisgender African American youths. Measures considered were bullying victimization, delinquent behavior, sexual orientation/gender identity, motivation to move out, and family demographics. Sexual orientation/gender identity was not associated with youth delinquent behavior after controlling for covariates. Being motivated to …


Cyanobacteria And Phytoplankton Responses To Nutrients In Deep-Water Montane Reservoirs, Madeleine Paige Malmfeldt Dec 2021

Cyanobacteria And Phytoplankton Responses To Nutrients In Deep-Water Montane Reservoirs, Madeleine Paige Malmfeldt

Theses and Dissertations

Mountains play an important role in providing water resources from snow and ice to downstream urban population centers. In Utah, USA, nearly 86% of the state's population resides in the rapidly growing urban corridor along the Wasatch Front. Water along the Wasatch Front is stored in several deep reservoirs in the Provo River Watershed. Additions of nutrients, into these reservoirs, may stimulate the growth of primary producers (e.g., total phytoplankton and cyanobacteria) potentially attenuating water quality. To determine the influence of nutrients on primary producers in the Provo River's reservoirs, identify whether cyanobacteria are transported downstream, and quantify nutrient thresholds …


Evidence Of Myomir Regulation Of The Pentose Phosphate Pathway During Mechanical Load-Induced Hypertrophy, Taylor Valentino, Vandre C. Figueiredo, C. Brooks Mobley, John J. Mccarthy, Ivan J. Vechetti Jr. Dec 2021

Evidence Of Myomir Regulation Of The Pentose Phosphate Pathway During Mechanical Load-Induced Hypertrophy, Taylor Valentino, Vandre C. Figueiredo, C. Brooks Mobley, John J. Mccarthy, Ivan J. Vechetti Jr.

Physiology Faculty Publications

Many of the molecular and cellular mechanisms discovered to regulate skeletal muscle hypertrophy were first identified using the rodent synergist ablation model. This model reveals the intrinsic capability and necessary pathways of skeletal muscle growth in response to mechanical overload (MOV). Reminiscent of the rapid cellular growth observed with cancer, we hypothesized that in response to MOV, skeletal muscle would undergo metabolic programming to sustain increased demands to support hypertrophy. To test this hypothesis, we analyzed the gene expression of specific metabolic pathways taken from transcriptomic microarray data of a MOV time course. We found an upregulation of genes involved …


Campus Guide, Memphis State University, Circa 1971 Dec 2021

Campus Guide, Memphis State University, Circa 1971

Documents

Campus guide of Memphis State University, Memphis, Tennessee, circa 1971.


Defects Analysis And Root Cause Robustness Of Product Labels Of An Acaricide Product In East Africa, Moses Okal Ogodo, Z Ekeocha, S Byrn, K Clase Dec 2021

Defects Analysis And Root Cause Robustness Of Product Labels Of An Acaricide Product In East Africa, Moses Okal Ogodo, Z Ekeocha, S Byrn, K Clase

BIRS Africa Technical Report Papers

This project aimed at investigating online damages of packaging materials generated during production because of imperfectness of production processes. These online damages may lead to upsurge in production cost and/or market returns, causing the company to experience losses and even damage its reputation. Data on online damages were collected for 20ml, 40ml and 100ml labels of an acaricide product for the period between July 2018 and June 2019 and statistically analyzed. Investigation was done on the causes of online damages, then corrective and preventive actions carried out. Analysis of online damages of labels of the three pack sizes revealed a …


Medicines Regulation In West Africa: Current State And Opportu-Nities, Oluwafunmike Sopein-Mann, Z Ekeocha, S Byrn, K Clase Dec 2021

Medicines Regulation In West Africa: Current State And Opportu-Nities, Oluwafunmike Sopein-Mann, Z Ekeocha, S Byrn, K Clase

BIRS Africa Technical Report Papers

Ndomondo-Sigonda et al. (2017) observed that there is scarcity of information on human resources (person-nel devoted to regulation of medicines) in the domain of medicines regulation in the sub-Saharan Africa (SSA). The published information on medicines regulation by the National Medicines Regulatory Authorities (NMRAs) in the Economic Community of West African States (ECOWAS) region are no longer current and consistent with the current realities in the NMRAs. In order to reveal this occurrence, show the trends that exist over the years and make appropriate recommendations, data were collected and compared from 2005, 2010 and 2017 research reports on seven regulatory …


Quality Of Sample Testing In The Laboratory Unit: Current Situation And Strategies For Improvement, Aloyce Constantine, Z Ekeocha, S Byrn, K Clase Dec 2021

Quality Of Sample Testing In The Laboratory Unit: Current Situation And Strategies For Improvement, Aloyce Constantine, Z Ekeocha, S Byrn, K Clase

BIRS Africa Technical Report Papers

The purpose of this study was to understand the status quo of quality sample testing in the laboratory unit. A quantitative research method was used. An extensive laboratory documents (protocol, worksheets, laboratory analytical plan, standard operating procedures and manuals) review was performed and a networking approach to both management and lab staff at all levels was reviewed in order to identify all non-conformities occurred in the past three years. Results identified 36 number of results deviated from reference standards among different test performed, 400 number of samples lost, the number of laboratory personnel who were not sufficiently trained to take …


Pharmaceutical Industry In Uganda: A Review Of The Common Gmp Non-Conformances During Regulatory Inspections, Nasser Lubowa, Z Ekeocha, S Byrn, K Clase Dec 2021

Pharmaceutical Industry In Uganda: A Review Of The Common Gmp Non-Conformances During Regulatory Inspections, Nasser Lubowa, Z Ekeocha, S Byrn, K Clase

BIRS Africa Technical Report Papers

The prevalence of substandard medicines in Africa is high but not well documented. Low and Middle-Income Countries (LMICs) are likely to face considerable challenges with substandard medications. Africa faces inadequate drug regulatory practices, and in general, compliance with Good Manufacturing Practices (GMP) in most of the pharmaceutical industries is lacking. The majority of pharmaceutical manufacturers in developing countries are often overwhelmed by the GMP requirements and therefore are unable to operate in line with internationally acceptable standards. Non-conformances observed during regulatory inspections provide the status of the compliance to GMP requirements. The study aimed to identify the GMP non-conformances during …


The Impact Of Mentoring As A Gmp Capability Building Tool In The Pharmaceutical Manufacturing Industry In Nigeria, Monica Agu, Z Ekeocha, S Byrn, K Clase Dec 2021

The Impact Of Mentoring As A Gmp Capability Building Tool In The Pharmaceutical Manufacturing Industry In Nigeria, Monica Agu, Z Ekeocha, S Byrn, K Clase

BIRS Africa Technical Report Papers

Good Manufacturing Practices (GMP), a component of Pharmaceutical Quality Systems, is aimed primarily at managing and minimizing the risks inherent in pharmaceutical manufacture to ensure the quality, safety and efficacy of products. Provision of adequate number of personnel with the necessary qualifications/practical experience and their continuous training and evaluation of effectiveness of the training is the responsibility of the manufacturer. (World Health Organization [WHO], 2014; International Organization for Standardization [ISO], 2015). The classroom method of training that has been used for GMP capacity building in the pharmaceutical manufacturing industry in Nigeria over the years, delivered by experts from stringently regulated …


Retrospective Study Of Inspectors Competency In The Act Of Writing Gmp Inspection Report, Chidi Uche, Z Ekeocha, S Byrn, K Clase Dec 2021

Retrospective Study Of Inspectors Competency In The Act Of Writing Gmp Inspection Report, Chidi Uche, Z Ekeocha, S Byrn, K Clase

BIRS Africa Technical Report Papers

The research was a retrospective study of twenty-five Good Manufacturing Practice (GMP) inspection reports (from March 2017 through to December 2018) of a national medicine regulatory agency, drug Inspectorate, in West Africa, designed to assess the inspectors’ expertise in the act of inspection report writing. The investigation examined a paper-based tool of thirteen pre-registration Inspection reports and twelve GMP reassessment reports written prior and following an intervention program by external GMP trainers to enhance inspectors’ skill in pharmaceutical cGMP inspection. The study made use of quantitative analysis to investigate each team’s expertise in the act of writing GMP inspection report. …


The Montclarion, December 9, 2021, The Montclarion Dec 2021

The Montclarion, December 9, 2021, The Montclarion

The Montclarion

Student Newspaper of Montclair State University


The Cowl - V. 86 N. 10 - Dec 9, 2021 Dec 2021

The Cowl - V. 86 N. 10 - Dec 9, 2021

The Cowl

The Cowl - student newspaper of Providence College. Vol. 86 No. 10 - December 9, 2021. 40 pages.


Periode Inkubasi, Tingkat Keparahan, Dan Ketahanan Sepuluh Genotipe Padi Harapan Terhadap Penyakit Hawar Daun Bakteri Strain Iii, Iv, Dan Viii, Nono Carsono, Anggita Dewi, Noladhi Wicaksana, Santika Sari Dec 2021

Periode Inkubasi, Tingkat Keparahan, Dan Ketahanan Sepuluh Genotipe Padi Harapan Terhadap Penyakit Hawar Daun Bakteri Strain Iii, Iv, Dan Viii, Nono Carsono, Anggita Dewi, Noladhi Wicaksana, Santika Sari

Jurnal Kultivasi

Genotipe padi harapan dari UNPAD memiliki keunggulan pada daya hasil, tahan terhadap wereng coklat, memiliki amilosa sedang, aromatik dan kualitas bulir yang sangat baik. Pengujian ketahanan genotipe padi harapan yang berasal dari hasil seleksi molekuler dan fenotipik terhadap penyakit hawar daun bakteri (HDB) sangatlah dibutuhkan, karena ketahanan terhadap penyakit ini merupakan salah satu syarat pelepasan varietas padi di Indonesia. Penyakit HDB disebabkan oleh bakteri Xanthomonas oryzae pv. oryzae (Xoo) merupakan penyakit penting yang sering menyerang tanaman padi. Tujuan dari penelitian ini adalah untuk memperoleh informasi potensi genotipe-genotipe padi yang tahan terhadap penyakit HDB yang disebabkan oleh Xoo strain III, IV, …


Understanding Factors Influencing Seed Germination Of Seven Wildflowers In Sub-Alpine Ecosystems, Alyssa Joy Brown Dec 2021

Understanding Factors Influencing Seed Germination Of Seven Wildflowers In Sub-Alpine Ecosystems, Alyssa Joy Brown

Theses and Dissertations

This thesis explores the seed germination of seven wildflowers native to sub-alpine ecosystems. Wildflowers are an essential functional group in native plant ecosystems. Also known as forbs, these plants offer a myriad of benefits in addition to being aesthetically pleasing. They provide habitats for anthropods and small mammals, support native pollinator populations, and grow well with other plant functional groups (especially perennial grasses and shrubs). Healthy plant communities make use of the limited resources in our native ecosystems, competing with invasive species that can otherwise dominate the landscape. Germination involves the transition from seed to an actively growing plant. Following …


Late Cretaceous Paleoceanographic Evolution And The Onset Of Cooling In The Santonian At Southern High Latitudes (Iodp Site U1513, Se Indian Ocean), Maria Rose Petrizzo, Kenneth G. Macleod, David K. Watkins, Erik Wolfgring, Brian T. Huber Dec 2021

Late Cretaceous Paleoceanographic Evolution And The Onset Of Cooling In The Santonian At Southern High Latitudes (Iodp Site U1513, Se Indian Ocean), Maria Rose Petrizzo, Kenneth G. Macleod, David K. Watkins, Erik Wolfgring, Brian T. Huber

Department of Earth and Atmospheric Sciences: Faculty Publications

The latest Cenomanian to Santonian sedimentary record recovered at IODP Expedition 369 Site U1513 in the Mentelle Basin (SE Indian Ocean, paleolatitude 60°S at 85 Ma) is studied to interpret the paleoceanographic evolution in the Southern Hemisphere. The planktonic foraminiferal assemblage changes, the depth ecology preferences of different species, and the surface and seafloor temperature inferred from the stable isotopic values measured on foraminiferal tests provide meaningful information to the understanding of the Late Cretaceous climate. The hothouse climate during the Turonian-Santonian, characterized by weak latitudinal temperature gradients and high atmospheric CO2 concentrations, is followed by a progressive cooling …


Sustainable Intensification For A Larger Global Rice Bowl, Shen Yuan, Bruce A. Linquist, Lloyd T. Wilson, Kenneth G. Cassman, Alexander M. Stuart, Valerien Pede, Berta Miro, Kazuki Saito, Nurwulan Agustiani, Vina Eka Aristya, Leonardus Y. Krisnadi, Alencar Junior Zanon, Alexandre Bryan Heinemann, Gonzalo Carracelas, Nataraja Subash, Pathula S. Brahmanand, Tao Li, Shaobing Peng, Patricio Grassini Dec 2021

Sustainable Intensification For A Larger Global Rice Bowl, Shen Yuan, Bruce A. Linquist, Lloyd T. Wilson, Kenneth G. Cassman, Alexander M. Stuart, Valerien Pede, Berta Miro, Kazuki Saito, Nurwulan Agustiani, Vina Eka Aristya, Leonardus Y. Krisnadi, Alencar Junior Zanon, Alexandre Bryan Heinemann, Gonzalo Carracelas, Nataraja Subash, Pathula S. Brahmanand, Tao Li, Shaobing Peng, Patricio Grassini

Department of Agronomy and Horticulture: Faculty Publications

Future rice systems must produce more grain while minimizing the negative environmental impacts. A key question is how to orient agricultural research & development (R&D) programs at national to global scales to maximize the return on investment. Here we assess yield gap and resource-use efficiency (including water, pesticides, nitrogen, labor, energy, and associated global warming potential) across 32 rice cropping systems covering half of global rice harvested area. We show that achieving high yields and high resource-use efficiencies are not conflicting goals. Most cropping systems have room for increasing yield, resource-use efficiency, or both. In aggregate, current total rice production …


Modeling Nitrous Oxide Emissions From Large-Scale Intensive Cropping Systems In The Southern Amazon, Ciniro Costa Jr., Gillian L. Galford, Michael T. Coe, Marcia Macedo, Kathijo Jankowski, Christine S. O'Connell, Christopher Neill Dec 2021

Modeling Nitrous Oxide Emissions From Large-Scale Intensive Cropping Systems In The Southern Amazon, Ciniro Costa Jr., Gillian L. Galford, Michael T. Coe, Marcia Macedo, Kathijo Jankowski, Christine S. O'Connell, Christopher Neill

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Nitrogen (N) fertilizer use is rapidly intensifying on tropical croplands and has the potential to increase emissions of the greenhouse gas, nitrous oxide (N2O). Since about 2005 Mato Grosso (MT), Brazil has shifted from single-cropped soybeans to double-cropping soybeans with maize, and now produces 1.5% of the world's maize. This production shift required an increase in N fertilization, but the effects on N2O emissions are poorly known. We calibrated the process-oriented biogeochemical DeNitrification-DeComposition (DNDC) model to simulate N2O emissions and crop production from soybean and soybean-maize cropping systems in MT. After model validation with …


Nutrient Intake And Dietary Inflammatory Potential In Current And Recovered Anorexia Nervosa, Olivia Patsalos, Bethan Dalton, Christia Kyprianou, Joseph Firth, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert Scd, Ulrike Schmidt, Hubertus Himmerich Dec 2021

Nutrient Intake And Dietary Inflammatory Potential In Current And Recovered Anorexia Nervosa, Olivia Patsalos, Bethan Dalton, Christia Kyprianou, Joseph Firth, Nitin Shivappa Mbbs, Mph, Ph.D., James Hébert Scd, Ulrike Schmidt, Hubertus Himmerich

Faculty Publications

Anorexia nervosa (AN) is characterised by disrupted and restrictive eating patterns. Recent investigations and meta-analyses have found altered concentrations of inflammatory markers in people with current AN. We aimed to assess nutrient intake in participants with current or recovered AN, as compared to healthy individuals, and explore group differences in dietary inflammatory potential as a possible explanation for the observed alterations in inflammatory markers. We recruited participants with current AN (n = 51), those recovered from AN (n = 23), and healthy controls (n = 49). We used the Food Frequency Questionnaire (FFQ), to calculate a Dietary …


Inhibition Of Viral Membrane Fusion By Peptides And Approaches To Peptide Design, Nejat Düzgüneş, Narcis Fernandez-Fuentes, Krystyna Konopka Dec 2021

Inhibition Of Viral Membrane Fusion By Peptides And Approaches To Peptide Design, Nejat Düzgüneş, Narcis Fernandez-Fuentes, Krystyna Konopka

Pacific Faculty Work

Fusion of lipid-enveloped viruses with the cellular plasma membrane or the endosome membrane is mediated by viral envelope proteins that undergo large conformational changes following binding to receptors. The HIV-1 fusion protein gp41 undergoes a transition into a “six-helix bundle” after binding of the surface protein gp120 to the CD4 receptor and a co-receptor. Synthetic peptides that mimic part of this structure interfere with the formation of the helix structure and inhibit membrane fusion. This approach also works with the S spike protein of SARS-CoV-2. Here we review the peptide inhibitors of membrane fusion involved in infection by influenza virus, …


Could There Be A Good Side To Covid-19 Pandemic?, Donna Shaw, Theressa Brahim, Catherina Chang Martinez Dec 2021

Could There Be A Good Side To Covid-19 Pandemic?, Donna Shaw, Theressa Brahim, Catherina Chang Martinez

Nursing & Health Sciences Research Journal

As the COVID-19 pandemic unfolded, resulting in loss of lives, burnout, anxiety, and depression related to social distancing and quarantine measures, some positive changes have been reported at the individual, interpersonal, and community level. Self-reflection, social connectedness, connectivity, innovation, and resilience have emerged as positive values that have contributed to decrease in burnout during the post-COVID pandemic era.


Spatiotemporal Variation Of An Eastern Tropical Pacific Pelagic Community Assessed With Free-Drifting Bruvs, Tyler Stephen Plum Dec 2021

Spatiotemporal Variation Of An Eastern Tropical Pacific Pelagic Community Assessed With Free-Drifting Bruvs, Tyler Stephen Plum

All HCAS Student Capstones, Theses, and Dissertations

Information about pelagic community diversity and ecology generally lags far behind that of coastal communities, and largely derives from fisheries data that do not reflect small and non-target species. We describe spatiotemporal vertebrate species diversity and variability over a 3,486 km2 area of highly productive pelagic marine ecosystem in Pacific Panama using drifting baited remote underwater video stations (BRUVS), a non-invasive fishery-independent sampling technique. We observed 26 taxa from 17 families, including 1 mammal, 3 reptile, 5 elasmobranch, and 17 teleost species. Community assemblages differed on and off the continental shelf and between wet (April – December) and dry …


Epigenome-Wide Association Study Of Serum Urate Reveals Insights Into Urate Co-Regulation And The Slc2a9 Locus, Adrienne Tin, Pascal Schlosser, Pamela R Matias-Garcia, Chris H L Thio, Roby Joehanes, Hongbo Liu, Zhi Yu, Antoine Weihs, Anselm Hoppmann, Franziska Grundner-Culemann, Josine L Min, Victoria L Halperin Kuhns, Adebowale A Adeyemo, Charles Agyemang, Johan Ärnlöv, Nasir A Aziz, Andrea Baccarelli, Murielle Bochud, Hermann Brenner, Jan Bressler, Monique M B Breteler, Cristian Carmeli, Layal Chaker, Josef Coresh, Tanguy Corre, Adolfo Correa, Simon R Cox, Graciela E Delgado, Kai-Uwe Eckardt, Arif B Ekici, Karlhans Endlich, James S Floyd, Eliza Fraszczyk, Xu Gao, Xīn Gào, Allan C Gelber, Mohsen Ghanbari, Sahar Ghasemi, Christian Gieger, Philip Greenland, Megan L Grove, Sarah E Harris, Gibran Hemani, Peter Henneman, Christian Herder, Steve Horvath, Lifang Hou, Mikko A Hurme, Shih-Jen Hwang, Sharon L R Kardia, Silva Kasela, Marcus E Kleber, Wolfgang Koenig, Jaspal S Kooner, Florian Kronenberg, Brigitte Kühnel, Christine Ladd-Acosta, Terho Lehtimäki, Lars Lind, Dan Liu, Donald M Lloyd-Jones, Stefan Lorkowski, Ake T Lu, Riccardo E Marioni, Winfried März, Daniel L Mccartney, Karlijn A C Meeks, Lili Milani, Pashupati P Mishra, Matthias Nauck, Christoph Nowak, Annette Peters, Holger Prokisch, Bruce M Psaty, Olli T Raitakari, Scott M Ratliff, Alex P Reiner, Ben Schöttker, Joel Schwartz, Sanaz Sedaghat, Jennifer A Smith, Nona Sotoodehnia, Hannah R Stocker, Silvia Stringhini, Johan Sundström, Brenton R Swenson, Joyce B J Van Meurs, Jana V Van Vliet-Ostaptchouk, Andrea Venema, Uwe Völker, Juliane Winkelmann, Bruce H R Wolffenbuttel, Wei Zhao, Yinan Zheng, Marie Loh, Harold Snieder, Melanie Waldenberger, Daniel Levy, Shreeram Akilesh, Owen M Woodward, Katalin Susztak, Alexander Teumer, Anna Köttgen Dec 2021

Epigenome-Wide Association Study Of Serum Urate Reveals Insights Into Urate Co-Regulation And The Slc2a9 Locus, Adrienne Tin, Pascal Schlosser, Pamela R Matias-Garcia, Chris H L Thio, Roby Joehanes, Hongbo Liu, Zhi Yu, Antoine Weihs, Anselm Hoppmann, Franziska Grundner-Culemann, Josine L Min, Victoria L Halperin Kuhns, Adebowale A Adeyemo, Charles Agyemang, Johan Ärnlöv, Nasir A Aziz, Andrea Baccarelli, Murielle Bochud, Hermann Brenner, Jan Bressler, Monique M B Breteler, Cristian Carmeli, Layal Chaker, Josef Coresh, Tanguy Corre, Adolfo Correa, Simon R Cox, Graciela E Delgado, Kai-Uwe Eckardt, Arif B Ekici, Karlhans Endlich, James S Floyd, Eliza Fraszczyk, Xu Gao, Xīn Gào, Allan C Gelber, Mohsen Ghanbari, Sahar Ghasemi, Christian Gieger, Philip Greenland, Megan L Grove, Sarah E Harris, Gibran Hemani, Peter Henneman, Christian Herder, Steve Horvath, Lifang Hou, Mikko A Hurme, Shih-Jen Hwang, Sharon L R Kardia, Silva Kasela, Marcus E Kleber, Wolfgang Koenig, Jaspal S Kooner, Florian Kronenberg, Brigitte Kühnel, Christine Ladd-Acosta, Terho Lehtimäki, Lars Lind, Dan Liu, Donald M Lloyd-Jones, Stefan Lorkowski, Ake T Lu, Riccardo E Marioni, Winfried März, Daniel L Mccartney, Karlijn A C Meeks, Lili Milani, Pashupati P Mishra, Matthias Nauck, Christoph Nowak, Annette Peters, Holger Prokisch, Bruce M Psaty, Olli T Raitakari, Scott M Ratliff, Alex P Reiner, Ben Schöttker, Joel Schwartz, Sanaz Sedaghat, Jennifer A Smith, Nona Sotoodehnia, Hannah R Stocker, Silvia Stringhini, Johan Sundström, Brenton R Swenson, Joyce B J Van Meurs, Jana V Van Vliet-Ostaptchouk, Andrea Venema, Uwe Völker, Juliane Winkelmann, Bruce H R Wolffenbuttel, Wei Zhao, Yinan Zheng, Marie Loh, Harold Snieder, Melanie Waldenberger, Daniel Levy, Shreeram Akilesh, Owen M Woodward, Katalin Susztak, Alexander Teumer, Anna Köttgen

Faculty, Staff and Student Publications

Elevated serum urate levels, a complex trait and major risk factor for incident gout, are correlated with cardiometabolic traits via incompletely understood mechanisms. DNA methylation in whole blood captures genetic and environmental influences and is assessed in transethnic meta-analysis of epigenome-wide association studies (EWAS) of serum urate (discovery, n = 12,474, replication, n = 5522). The 100 replicated, epigenome-wide significant (p < 1.1E-7) CpGs explain 11.6% of the serum urate variance. At SLC2A9, the serum urate locus with the largest effect in genome-wide association studies (GWAS), five CpGs are associated with SLC2A9 gene expression. Four CpGs at SLC2A9 have significant causal effects on serum urate levels and/or gout, and two of these partly mediate the effects of urate-associated GWAS variants. In other genes, including SLC7A11 and PHGDH, 17 urate-associated CpGs are associated with conditions defining metabolic syndrome, suggesting that these CpGs may represent a blood DNA methylation signature of cardiometabolic risk factors. This study demonstrates that EWAS can provide new insights into GWAS loci and the correlation of serum urate with other complex traits.


Hedgehog-Interacting Protein Is A Multimodal Antagonist Of Hedgehog Signalling, Samuel C Griffiths, Rebekka A Schwab, Kamel El Omari, Benjamin Bishop, Ellen J Iverson, Tomas Malinauskas, Ramin Dubey, Mingxing Qian, Douglas F Covey, Robert J C Gilbert, Rajat Rohatgi, Christian Siebold Dec 2021

Hedgehog-Interacting Protein Is A Multimodal Antagonist Of Hedgehog Signalling, Samuel C Griffiths, Rebekka A Schwab, Kamel El Omari, Benjamin Bishop, Ellen J Iverson, Tomas Malinauskas, Ramin Dubey, Mingxing Qian, Douglas F Covey, Robert J C Gilbert, Rajat Rohatgi, Christian Siebold

Open Access Publications

Hedgehog (HH) morphogen signalling, crucial for cell growth and tissue patterning in animals, is initiated by the binding of dually lipidated HH ligands to cell surface receptors. Hedgehog-Interacting Protein (HHIP), the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling, binds directly to SHH with high nanomolar affinity, sequestering SHH. Here, we report the structure of the HHIP N-terminal domain (HHIP-N) in complex with a glycosaminoglycan (GAG). HHIP-N displays a unique bipartite fold with a GAG-binding domain alongside a Cysteine Rich Domain (CRD). We show that HHIP-N is required to convey full HHIP inhibitory function, likely by interacting with the …


Regenerative Responses Of Rabbit Corneal Endothelial Cells To Stimulation By Fibroblast Growth Factor 1 (Fgf1) Derivatives, Tthx1001 And Tthx1114, Jessica Weant, David D Eveleth, Amuthakannan Subramaniam, Jennifer Jenkins-Eveleth, Michael Blaber, Ling Li, David M Ornitz, Asaf Alimardanov, Trevor Broadt, Hui Dong, Vinay Vyas, Xiaoyi Yang, Ralph A Bradshaw Dec 2021

Regenerative Responses Of Rabbit Corneal Endothelial Cells To Stimulation By Fibroblast Growth Factor 1 (Fgf1) Derivatives, Tthx1001 And Tthx1114, Jessica Weant, David D Eveleth, Amuthakannan Subramaniam, Jennifer Jenkins-Eveleth, Michael Blaber, Ling Li, David M Ornitz, Asaf Alimardanov, Trevor Broadt, Hui Dong, Vinay Vyas, Xiaoyi Yang, Ralph A Bradshaw

Open Access Publications

Utilising rabbit corneal endothelial cells (CEC) in three different paradigms, two human FGF1 derivatives (TTHX1001 and TTHX1114), engineered to exhibit greater stability, were tested as proliferative agents. Primary CECs and mouse NIH 3T3 cells treated with the two FGF1 derivatives showed equivalent EC


Lyl-1 Regulates Primitive Macrophages And Microglia Development, Shoutang Wang, Deshan Ren, Brahim Arkoun, Anna-Lila Kaushik, Gabriel Matherat, Yann Lécluse, Dominik Filipp, William Vainchenker, Hana Raslova, Isabelle Plo, Isabelle Godin Dec 2021

Lyl-1 Regulates Primitive Macrophages And Microglia Development, Shoutang Wang, Deshan Ren, Brahim Arkoun, Anna-Lila Kaushik, Gabriel Matherat, Yann Lécluse, Dominik Filipp, William Vainchenker, Hana Raslova, Isabelle Plo, Isabelle Godin

Open Access Publications

During ontogeny, macrophage populations emerge in the Yolk Sac (YS) via two distinct progenitor waves, prior to hematopoietic stem cell development. Macrophage progenitors from the primitive/"early EMP" and transient-definitive/"late EMP" waves both contribute to various resident primitive macrophage populations in the developing embryonic organs. Identifying factors that modulates early stages of macrophage progenitor development may lead to a better understanding of defective function of specific resident macrophage subsets. Here we show that YS primitive macrophage progenitors express Lyl-1, a bHLH transcription factor related to SCL/Tal-1. Transcriptomic analysis of YS macrophage progenitors indicate that primitive macrophage progenitors present at embryonic day …


Pengaruh Bahan Organik Terhadap Kesuburan Tanah Serta Pertumbuhan Dan Fisiologi Tanaman Kakao Muda Hasil Transplanting Di Tanah Inceptisol, Santi Rosniawaty, Rija Sudirja, Mira Ariyanti, Syariful Mubarok, Agus Wahyudin Dec 2021

Pengaruh Bahan Organik Terhadap Kesuburan Tanah Serta Pertumbuhan Dan Fisiologi Tanaman Kakao Muda Hasil Transplanting Di Tanah Inceptisol, Santi Rosniawaty, Rija Sudirja, Mira Ariyanti, Syariful Mubarok, Agus Wahyudin

Jurnal Kultivasi

Penanaman bibit kakao pada tanah inceptisol memiliki beberapa kendala, salah satunya adalah bahan organik rendah. Peningkatan pertumbuhan tanaman kakao pada awal tanam dapat dilakukan dengan pemberian bahan organik. Saat ini terdapat bahan organik berbentuk cair, namun pengaruhnya terhadap kakao belum menghasilkan belum diketahui, karena pada umumnya bahan organik yang digunakan pada tanaman kakao berbentuk padat. Tujuan penelitian ini untuk melihat pengaruh bahan organik berbeda (asam humat dan pupuk kotoran sapi) terhadap kesuburan tanah, pertumbuhan, dan fisiologi tanaman kakao belum menghasilkan. Percobaan dilakukan pada bulan Januari sampai Desember 2017 di kebun percobaan Fakultas Pertanian, Universitas Padjadjaran, Jatinangor. Rancangan percobaan yang digunakan …