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2021

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Discovering Virally Encoded Proteins That Block Type Iv Crispr Immune Systems, Andrew Williams Dec 2021

Discovering Virally Encoded Proteins That Block Type Iv Crispr Immune Systems, Andrew Williams

Fall Student Research Symposium 2021

Bacteria and the viruses that infect them have been at war from the beginnings of life until today. Due to selective pressure from viral infection, bacteria have evolved various biological defense systems, including CRISPR-Cas systems that use a genetic memory of previous viral encounters to protect against future invasions. However, recently it has been shown that viruses have evolved counter-strategies to evade CRISPR systems. Virally encoded proteins called anti-CRISPRs use a variety of mechanisms to block the activity of CRISPR immune systems in order to infect bacterial cells. The Jackson lab at USU recently showed that a Type IV-A CRISPR-Cas …

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Pan Variant Sars-Cov-2 Common Interactions And Drug Candidates, Kolton Hauck Dec 2021

Pan Variant Sars-Cov-2 Common Interactions And Drug Candidates, Kolton Hauck

Fall Student Research Symposium 2021

As the SARS-CoV-2 virus has spread, multiple strains have appeared. Research has investigated potential drug candidates for COVID-19, but without consideration for the multiple variants of SARS-CoV-2. A domain-based and interolog-based method were implemented to predict protein-protein interactions (PPIs) between the SARS-CoV-2 variants and human proteins. A common set (conserved among all strains) and a unique set (distinct for each strain) of interactions were made. These sets of interactions were characterized via subcellular localization, tissue expression, pathway enrichment and gene ontology. Lastly, drug candidates were identified for the common set. The combined domain and interolog methods resulted in 8963 predicted …

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Characterization Of The Atpase Activity Of Casding, Christian Cahoon Dec 2021

Characterization Of The Atpase Activity Of Casding, Christian Cahoon

Fall Student Research Symposium 2021

The battle between bacteria and phage has been ongoing for eons. This battle has generated the evolutionary pressure necessary for the development of microbial immune systems. Characterization of these systems has led to the discovery of molecular tools such CRISPR-Cas systems. This system uses a genetic memory of past viral infections coupled with associated proteins to form ribonucleoprotein complexes which seek out and destroy foreign genetic elements. These systems have been repurposed by scientists to create powerful gene editing tools such as Cas9. With such powerful molecular tools being discovered, we have pursued the characterization of a relatively unknown system, …

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Characterizing The Mechanisms Of C. Elegans Prmt1 Temperature Dependence, Arianna Towne Dec 2021

Characterizing The Mechanisms Of C. Elegans Prmt1 Temperature Dependence, Arianna Towne

Fall Student Research Symposium 2021

Over time, cellular enzymes evolve through amino acid mutations which allow them to remain functional at temperatures specific to the host organism. This activity may be partially or completely lost when enzymes are removed from their optimal temperature range, as is observed for the C. elegans protein arginine methyltransferase 1 (cPRMT1). This construct demonstrates maximum enzymatic activity at the C. elegans optimum of 20°C, but no activity at 37°C where activity for mammalian PRMT1 variants is observed. Given dysregulation of PRMT1 has been linked to various disease states, we are interested in exploiting the biophysical mechanisms of cPRMT1 temperature dependence …

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Determining The Nucleic Acid Binding Affinities Of Crispr-Associated Ding (Casding), Matt Armbrust Dec 2021

Determining The Nucleic Acid Binding Affinities Of Crispr-Associated Ding (Casding), Matt Armbrust

Fall Student Research Symposium 2021

CRISPR-Cas systems are adaptive prokaryotic immune systems that enable host cells to defend against attack from foreign nucleic acids such as phage infections or plasmids. CRISPR-Cas systems are diverse and encompass 2 classes, 6 types, and 33 subtypes. The Type IV-A CRISPR-Cas system from Pseudomonas aeruginosa strain 83 is composed of five different genes (csf1, csf2, csf3, cas6, and dinG). Type IV-A systems are poorly understood, and currently there is little research detailing their biological and biochemical mechanism of immunity. CasDinG, an ancillary protein within the Type IV-A system, is required for an immune response in vivo. However, the role …

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Establishing A Framework Of Nitrogen Acquisition For Martian Agriculture, Tyler Wallentine Dec 2021

Establishing A Framework Of Nitrogen Acquisition For Martian Agriculture, Tyler Wallentine

Fall Student Research Symposium 2021

Nitrogen (N) forms a crucial part of DNA, proteins, and other biomolecules and is an essential element to life. Luckily, N is abundant in Earth’s and Mars’ atmospheres in its atmospheric form (N2); however, plants and humans are unable to metabolize it in this state. N2 gas is only able to be consumed by undergoing nitrogen fixation, an intensive process that breaks the extremely-stable N ≡ N bond in order to form bioavailable ammonia (NH3). Many prokaryotes are capable of nitrogen fixation. Plants may uptake fixed N from these, which are then consumed by other …

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Determining The Biochemical Mechanisms And Binding Activities Of A Type Iv-A Crispr-Cas Ding Helicase, Matt Armbrust Dec 2021

Determining The Biochemical Mechanisms And Binding Activities Of A Type Iv-A Crispr-Cas Ding Helicase, Matt Armbrust

Fall Student Research Symposium 2021

CRISPR-Cas systems are adaptive prokaryotic immune systems that enable host cells to defend against attack from foreign nucleic acids such as phage infections or plasmids. CRISPR-Cas systems are diverse and encompass 2 classes, 6 types, and 33 subtypes. The Type IV-A CRISPR-Cas system from Pseudomonas aeruginosa strain 83 is composed of five different genes (csf1, csf2, csf3, cas6, and dinG). Type IV-A systems are poorly understood, and currently there is little research detailing their biological and biochemical mechanism of immunity. CasDinG, an ancillary protein within the Type IV-A system, is required for an immune response in vivo. However, the role …

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Measuring Irregularity Via Approximate Entropy: How Does Perceived Human Instability Affect One's Own Stability?, Madi Braunersrither Dec 2021

Measuring Irregularity Via Approximate Entropy: How Does Perceived Human Instability Affect One's Own Stability?, Madi Braunersrither

Fall Student Research Symposium 2021

In a study performed at Utah State University, participants were prompted to evaluate the stability of pictured human postures while standing on a force plate. The force plate was used to collect the center of pressure of the subjects by recording measurements in the vertical and horizontal directions. The way these factors fluctuate over time and the irregularity in this fluctuation, specifically, can give insight into the subject’s postural stability. Rather than working with summary statistics such as means and variances of fitting parameters of a distribution as commonly done in statistics, we want to measure irregularity through analyzing the …

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A Computational Model Of Angiogenesis In Wet Age-Related Macular Degeneration, Brandon Pace Dec 2021

A Computational Model Of Angiogenesis In Wet Age-Related Macular Degeneration, Brandon Pace

Fall Student Research Symposium 2021

Age-related macular degeneration (AMD) is a chronic disease which causes central blindness in the eye. This progressive disease is thought to affect 1 of every 4 people over the age of 80 living in developed countries, including America. There is no cure and the only treatments to halt disease progression involve biweekly eye injections for the rest of the patient’s life. Clearly there is a great need to understand AMD and find better treatment for the many afflicted. It is known that harmful capillary growth (angiogenesis) contributes to AMD. By learning more about retinal angiogenesis, we can understand AMD in …

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Effectiveness Of Cannabidiol And Resveratrol Against Diesel Exhaust Particle-Induced Lung Cell Cytotoxicity, Emily Brothersen Dec 2021

Effectiveness Of Cannabidiol And Resveratrol Against Diesel Exhaust Particle-Induced Lung Cell Cytotoxicity, Emily Brothersen

Fall Student Research Symposium 2021

Environmental air pollution poses a significant health risk to individuals across the world. Diesel exhaust particles (DEPs), a major component of air pollution, have been shown to cause lung damage leading to cancer, respiratory infections, and premature death. Antioxidants, such as resveratrol, have previously demonstrated protective properties against DEP-induced cytotoxicity and reactive oxygen species. Cannabinoids extracted from hemp species have also been found to have powerful antioxidant properties, though these properties have not been thoroughly explored. In this study, A549 human lung carcinoma cells were used as a cellular model to determine the effectiveness of cannabinoids’ antioxidant properties against DEP-induced …

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Understanding How Changes In Precipitation Intensity Will Affect Vegetation In The Western U.S., Cristina Chirvasa Dec 2021

Understanding How Changes In Precipitation Intensity Will Affect Vegetation In The Western U.S., Cristina Chirvasa

Fall Student Research Symposium 2021

Precipitation events are becoming more intense as the atmosphere warms, but it remains unclear how precipitation intensification will affect plant growth in arid and semiarid ecosystems. There is conflicting evidence suggesting that larger precipitation events may either increase or decrease plant growth. Here, we report the growth responses of herbaceous and woody plants to experimental manipulations of precipitation intensity in a cold, semi-arid ecosystem in Utah, USA. In this experiment, precipitation was collected and redeposited as fewer, larger events with total annual precipitation kept constant across treatments. Results from the first two growing seasons revealed that more intense events ‘pushed’ …

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Climate Change Impacts On Atmospheric Ammonia And Implications For Human Health, Casey Olson, Connor Snow, Bridger Jorgensen Dec 2021

Climate Change Impacts On Atmospheric Ammonia And Implications For Human Health, Casey Olson, Connor Snow, Bridger Jorgensen

Fall Student Research Symposium 2021

According to national data Cache Valley has the highest concentrations of atmospheric ammonia in the nation. This study aims to answer the questions of whether climate variables and events such as precipitation, averaged winds, geopotential height, and teleconnections can be used to predict the behavior of pollutants and how human biology is potentially affected. Data from the Utah Climate Center shows that the 3rd yearly quartile has the highest levels of airborne ammonia due to the high levels of fertilizer use and livestock emissions in the farming industry in Cache Valley. After data analysis, there seems to be a connection …

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Pcos: What They Should Be Telling You, Gracie Leavitt Dec 2021

Pcos: What They Should Be Telling You, Gracie Leavitt

Fall Student Research Symposium 2021

It is speculated that out of 14 million women in the United States, 70% are being affected by Polycystic Ovarian Syndrome, and yet it continues to be one of the most misdiagnosed or undiagnosed diseases. PCOS is a condition that stems from the endocrine system and is often determined by cysts in the ovaries, but studies have proven that that isn’t always the case nor the determining diagnostic criteria. Women aren’t given enough information when being diagnosed with PCOS, nor substantial treatment options. In a world with incredible medical advances and research happening continuously, PCOS seems to be lacking in …

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Synthetic Hagfish Slime Mimetics: Mechanical Characterization, Hayden Johns, Spencer Walker Dec 2021

Synthetic Hagfish Slime Mimetics: Mechanical Characterization, Hayden Johns, Spencer Walker

Fall Student Research Symposium 2021

Hagfish are ancient animals that eject a slime when attacked by predators. The slime that the hagfish emit is almost entirely composed of water but protein strands within the slime cause the slime to have incredible strength. However, these protein strands will be formed synthetically for the purposes of our experiment. To defend against foes, the Navy launches plastic ropes into the propellers of enemy warships in order to decrease the thrust of the motors. In a push to find a more biodegradable solution, the utilization of hagfish slime has shown great promise in stopping propellers.While we know that the …

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Estimating Cattle Density Using Wildlife Cameras, Emily Bonebrake Dec 2021

Estimating Cattle Density Using Wildlife Cameras, Emily Bonebrake

Fall Student Research Symposium 2021

Quantifying the abundance and distribution of animal populations is critical for effective wildlife research and management. Due to their cost-effectiveness, wildlife cameras have become an increasingly popular tool for estimating population densities. Previously, this technique relied on ‘capture-recapture’ models that utilized re-sightings of individually marked animals, but in recent years methods have been developed to estimate the population densities of unmarked animals. One such method is the random encounter and staying time (REST) technique, which does this by assuming that the cumulative time animals stay within the view of the camera scales linearly with the number of individuals. This allows …

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Effect Of Basal Diet And Black Raspberry Supplementation On Gene Biomarkers Of "Leaky Gut" In Mouse Model Of Colitis-Associated Colorectal Cancer, Eliza Stewart Dec 2021

Effect Of Basal Diet And Black Raspberry Supplementation On Gene Biomarkers Of "Leaky Gut" In Mouse Model Of Colitis-Associated Colorectal Cancer, Eliza Stewart

Fall Student Research Symposium 2021

Colorectal cancer is currently the third leading cause of cancer death in the world. The risk of developing colorectal cancer increases significantly in individuals who suffer from colitis, which is inflammation of the colon lining, seen in Irritable Bowel Disease. The term “leaky gut” is often used to describe increased intestinal permeability and is closely related to colitis. Leaky gut is associated with dysbiosis of the gut microbiota, which can occur through diet. This dysbiosis leads to pro-longed inflammation and affects genes that encode for proteins involved in the tight junctions between cells. Compromised intestinal integrity allows for translocation of …

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Digitization Of Entomological Collections At Usu, Eastern Using Scan (Symbiota Collections Of Arthropods Network) Data Portal And Seek! Inaturalist App, Alexandra Cartwright Dec 2021

Digitization Of Entomological Collections At Usu, Eastern Using Scan (Symbiota Collections Of Arthropods Network) Data Portal And Seek! Inaturalist App, Alexandra Cartwright

Fall Student Research Symposium 2021

Pollinators, including bees, provide valuable ecosystem services for native plants and agricultural species. Phenology, or the timing of biological events such as flowering of plants, is changing as a result of climate change. The digitization of specimens allows for insights into species distributions, seasonality, and phenology in 60-70-year-old collections. The entomological collection at Utah State University, Eastern houses approximately 3,000 individual specimens and over 100 bees. The oldest specimens date from 1953, many from the 1960s, 70s, & 80s and the majority of specimens are from Carbon and Emery Counties. Digitization of entomological collections can provide: species distributions: Which species …

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Responses Of Benthic Calcifying Algae To Ocean Acidification Differ Between Laboratory And Field Settings, Heather N. Page, Keisha D. Bahr, Tyler Cyronak, Elizabeth B. Jewett, Maggie D. Johnson, Sophie J. Mccoy Dec 2021

Responses Of Benthic Calcifying Algae To Ocean Acidification Differ Between Laboratory And Field Settings, Heather N. Page, Keisha D. Bahr, Tyler Cyronak, Elizabeth B. Jewett, Maggie D. Johnson, Sophie J. Mccoy

Marine & Environmental Sciences Faculty Articles

Accurately predicting the effects of ocean and coastal acidification on marine ecosystems requires understanding how responses scale from laboratory experiments to the natural world. Using benthic calcifying macroalgae as a model system, we performed a semi-quantitative synthesis to compare directional responses between laboratory experiments and field studies. Variability in ecological, spatial, and temporal scales across studies, and the disparity in the number of responses documented in laboratory and field settings, make direct comparisons difficult. Despite these differences, some responses, including community-level measurements, were consistent across laboratory and field studies. However, there were also mismatches in the directionality of many responses …

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Improving Pharmacovigilliance Quality Management System In The Pharmacy And Poisions Board Of Kenya, Eric Apiyo, Z Ekeocha, S Byrn, K Clase Dec 2021

Improving Pharmacovigilliance Quality Management System In The Pharmacy And Poisions Board Of Kenya, Eric Apiyo, Z Ekeocha, S Byrn, K Clase

BIRS Africa Technical Report Papers

The purpose of this study was to explore ways of improving the pharmacovigilance quality system employed by the Pharmacy and Poisons Board of Kenya. The Pharmacy and Poisons Board of Kenya employs a hybrid system of pharmacovigilance that utilizes an online system of reporting pharmacovigilance incidences and a physical system, where a yellow book is physically filled by the healthcare worker and sent to the Pharmacy and Poisons Board for onward processing. This system, even though it has been relatively effective compared to other systems employed in Africa, has one major flaw. It is a slow and delayed system that …

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The Price Of Surviving On Adrenaline: Developmental Programming Responses To Chronic Fetal Hypercatecholaminemia Contribute To Poor Muscle Growth Capacity And Metabolic Dysfunction In Iugr-Born Offspring, Rachel L. Gibbs, Dustin T. Yates Dec 2021

The Price Of Surviving On Adrenaline: Developmental Programming Responses To Chronic Fetal Hypercatecholaminemia Contribute To Poor Muscle Growth Capacity And Metabolic Dysfunction In Iugr-Born Offspring, Rachel L. Gibbs, Dustin T. Yates

Department of Animal Science: Faculty Publications

Maternofetal stress induces fetal programming that restricts skeletal muscle growth capacity and metabolic function, resulting in intrauterine growth restriction (IUGR) of the fetus. This thrifty phenotype aids fetal survival but also yields reduced muscle mass and metabolic dysfunction after birth. Consequently, IUGR-born individuals are at greater lifelong risk for metabolic disorders that reduce quality of life. In livestock, IUGR-born animals exhibit poor growth efficiency and body composition, making these animals more costly and less valuable. Specifically, IUGR-associated programming causes a greater propensity for fat deposition and a reduced capacity for muscle accretion. This, combined with metabolic inefficiency, means that these …

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Vista: December 9, 2021, University Of San Diego Dec 2021

Vista: December 9, 2021, University Of San Diego

USD Vista (1965-)

No abstract provided.

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Element Contamination In Port Everglades – Preparing For Ecological Impacts, Laura White Dec 2021

Element Contamination In Port Everglades – Preparing For Ecological Impacts, Laura White

All HCAS Student Capstones, Theses, and Dissertations

Port dredging is of economic importance worldwide but its impacts to the marine environment through the remobilization of elemental contaminants are not well understood. A massive deepening and widening of Port Everglades, Florida, will begin in 2023. Contaminated sediment disturbed during the dredging process could be released and prove to be harmful to three coral reef tracks located beginning 1.5 miles away from the port. This study focused on identifying and quantifying 14 different trace elements: arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), mercury (Hg), lead (Pb), manganese (Mn), molybdenum (Mo), nickel (Ni), selenium (Se), tin (Sn), …

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Smooth Muscle Cells Affect Differential Nanoparticle Accumulation In Disturbed Blood Flow-Induced Murine Atherosclerosis, Hunter Miller, Morgan A. Schake, Badrul Alam Bony, Evan T. Curtis, Conner C. Gee, Ian Mccue, Thomas J. Ripperda Jr., Yiannis S. Chatzizisis, Forrest Kievit, Ryan M. Pedrigi Dec 2021

Smooth Muscle Cells Affect Differential Nanoparticle Accumulation In Disturbed Blood Flow-Induced Murine Atherosclerosis, Hunter Miller, Morgan A. Schake, Badrul Alam Bony, Evan T. Curtis, Conner C. Gee, Ian Mccue, Thomas J. Ripperda Jr., Yiannis S. Chatzizisis, Forrest Kievit, Ryan M. Pedrigi

Department of Mechanical and Materials Engineering: Faculty Publications

Atherosclerosis is a lipid-driven chronic inflammatory disease that leads to the formation of plaques in the inner lining of arteries. Plaques form over a range of phenotypes, the most severe of which is vulnerable to rupture and causes most of the clinically significant events. In this study, we evaluated the efficacy of nanoparticles (NPs) to differentiate between two plaque phenotypes based on accumulation kinetics in a mouse model of atherosclerosis. This model uses a perivascular cuff to induce two regions of disturbed wall shear stress (WSS) on the inner lining of the instrumented artery, low (upstream) and multidirectional (downstream), which, …

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Defining Disparities In Cochlear Implantation Through The Social Determinants Of Health, Marissa Schuh, Matthew L. Bush Dec 2021

Defining Disparities In Cochlear Implantation Through The Social Determinants Of Health, Marissa Schuh, Matthew L. Bush

Otolaryngology--Head & Neck Surgery Faculty Publications

Hearing loss is a global public health problem with high prevalence and profound impacts on health. Cochlear implantation (CI) is a well-established evidence-based treatment for hearing loss; however, there are significant disparities in utilization, access, and clinical outcomes among different populations. While variations in CI outcomes are influenced by innate biological differences, a wide array of social, environmental, and economic factors significantly impact optimal outcomes. These differences in hearing health are rooted in inequities of health-related socioeconomic resources. To define disparities and advance equity in CI, there is a pressing need to understand and target these social factors that influence …

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The Scoop On Composting: A Comprehensive Literature Review On Composting With A Focus On Grand Valley State University, Alexandria Snabes Dec 2021

The Scoop On Composting: A Comprehensive Literature Review On Composting With A Focus On Grand Valley State University, Alexandria Snabes

Honors Projects

This comprehensive review discusses the main microbial processes, methods, efficiency strategies, benefits, and drawbacks related to composting. Specifically, anaerobic, aerobic, and intermediate, or cold composting, decomposition processes are defined and assessed. This leads into a discussion of some common methods of composting, both large- and small-scale, which utilize these microbial processes to result in differing advantages and disadvantages. The efficiency of these methods can be increased using strategies that monitor oxygen levels, moisture levels, temperate levels, and overall size. Some benefits of composting discussed include diverting waste from landfills, improving soil nutrition and quality long-term, and increasing plant growth and …

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Unh Receives Over $3 Million For Multi-State Coastal Restoration And Resilience Program, Robbin Ray Dec 2021

Unh Receives Over $3 Million For Multi-State Coastal Restoration And Resilience Program, Robbin Ray

Media Relations

No abstract provided.

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Memphis State University Recruitment Pamphlet, Circa 1971 Dec 2021

Memphis State University Recruitment Pamphlet, Circa 1971

Documents

Student recruitment pamphlet of Memphis State University, Memphis, Tennessee, circa 1971.

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Aquaporin Expression And Cholesterol Content In Eel Swimbladder Tissue, Victoria Drechsel, Gabriel Schneebauer, Birgit Fiechtner, Christopher P. Cutler, Bernd Pelster Dec 2021

Aquaporin Expression And Cholesterol Content In Eel Swimbladder Tissue, Victoria Drechsel, Gabriel Schneebauer, Birgit Fiechtner, Christopher P. Cutler, Bernd Pelster

Biology: Faculty Publications

Leakiness of the swimbladder wall of teleost fishes must be prevented to avoid diffusional loss of gases out of the swimbladder. Guanine incrustation as well as high concentrations of cholesterol in swimbladder membranes in midwater and deep-sea fish has been connected to a reduced gas permeability of the swimbladder wall. On the contrary, the swimbladder is filled by diffusion of gases, mainly oxygen and CO2, from the blood and the gas gland cells into the swimbladder lumen. In swimbladder tissue of the zebrafish and the Japanese eel, aquaporin mRNA has been detected, and the aquaporin protein has been considered important …

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Exploring The Impact Of Social Influence Mechanisms And Network Density On Societal Polarization, Justin Mittereder Dec 2021

Exploring The Impact Of Social Influence Mechanisms And Network Density On Societal Polarization, Justin Mittereder

Departmental Honors & Graduate Capstone Projects

I present an agent-based model, inspired by the opinion dynamics
(OD) literature, to explore the underlying behaviors that may induce
societal polarization. My agents interact on a social network, in which
adjacent nodes can influence each other, and each agent holds an array
of continuous opinion values (on a 0-1 scale) on a number of separate
issues. I use three measures as a proxy for the virtual society’s “po-
larization:” the average assortativity of the graph with respect to the
agents’ opinions, the number of non-uniform issues, and the number
of distinct opinion buckets in which agents have the same …

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An Assessment Of The Diverse Freshwater Turtle Fauna Of Mississippi, Lucas Haralson Dec 2021

An Assessment Of The Diverse Freshwater Turtle Fauna Of Mississippi, Lucas Haralson

Master's Theses

Nestled within the Southeastern United States Turtle Priority Area, Mississippi boasts impressive freshwater turtle diversity and is home to 8.6% of extant turtle species. Despite this impressive richness, few studies have assessed freshwater turtle assemblages in this hotspot of aquatic diversity. This research aimed to elucidate the distributions and abundances of freshwater turtle species through a statewide investigation of all major river drainages of the state. Using baited hoop nets (90 cm and 120 cm diameter), turtles were collected, identified to species and sex, and measured, before being released. Turtle assemblages were assessed in both lotic and lentic environments from …

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