Digital Commons Network^™

Getting Scale Right: Multi Stakeholder Forums For Large Scale Management Of Mobile Livestock Production Systems In The Republic Of Niger, Thomas Sommerhalter

IGC Proceedings (1977-2023)

No abstract provided.

Knowledge Evolution And Policy Changes In Rangeland Management Of Hkh Region, Karma Phunthso, Shaoliang Yi

IGC Proceedings (1977-2023)

No abstract provided.

Grassland — A Resource For Sustenance In South India, B. K. Trivedi, Anil Kumar, S. Natrajan, Nagaratna Biradar

IGC Proceedings (1977-2023)

No abstract provided.

Casting Off The "Fertile Poverty": Policy Research On Development Of The Altiplano Pasturing Area Within The Upper Reaches Of The Yangtze River--Case Study Of Ganzi Tibetan Autonomous Prefecture, Shiqing Liu

IGC Proceedings (1977-2023)

No abstract provided.

The Changes In The Management Of Permanent Grasslands In The Cr After Agriculture Restructuring At The End Of The 20th Century, A. Kohoutek, Jan Pozdíšek

IGC Proceedings (1977-2023)

No abstract provided.

Penerus Tahta Dalam Pemerintahan Daerah Di Provinsi Daerah Istimewa Yogyakarta Berdasarakan Putusan Mahkamah Konstitusi Nomor 88/Puu-Xiv/2016, Delima Sianipar

"Dharmasisya” Jurnal Program Magister Hukum FHUI

Human rights are God-given rights inherent to all human beings. Men and women are entitled to the same rights. It includes obtaining the equal opportunities in government. Special Region of Yogyakarta is oen of the provinces that has particular authorities. The reigning king in the Yogyakarta Sultanate will automatically be appointed as the Governor of Special Region of Yogyakarta Province. The particularity of Yogyakarta is regulated in Act Number 13 of 2012 on the privileges of Special Region of Yogyakarta. Article 18 section (1) point mof Act Number 13 of 2012 on the Privileges of Special Region of Yogyakarta is …

“Born Under My Heart”: Adoptive Parents' Use Of Metaphors To Make Sense Of Their Past, Present, And Future, Lucas Hackenburg, Toni Morgan, Eve Brank

Faculty Creative and Scholarly Works

Metaphors provide the opportunity to make sense of our experiences and share them with others. The current research qualitatively examined interviews with adoptive parents who had adopted through intercountry or private adoptions. Throughout their interviews, each participant used at least one metaphor in describing their experiences of adopting and raising their child. Overarchingly, the metaphor of “Adoption is a journey” encapsulated parents’ experiences. To demonstrate the journey, parents used metaphors to describe the past, present, and future. Metaphors of the past focused on their child's trauma and the origin of how the child came to join their family. Metaphors used …

Common Spatial Pattern Detection Of Concept Semantic Relatedness Using Combined Event-Related Potentials And Frequency Spectrum Features, Michael Doyel

Graduate Theses - Biology & Biomedical Engineering

No abstract provided.

Causal Mediation Analysis With Multiple Time-Varying Mediators, An-Shun Tai, Sheng-Hsuan Lin, Yu-Cheng Chu, Tsung Yu, Milo A. Puhan, Tyler Vanderweele

Harvard University Biostatistics Working Paper Series

In longitudinal studies with time-varying exposures and mediators, the mediational g-formula is an important method for the assessment of direct and indirect effects. However, current methodologies based on the mediational g-formula can deal with only one mediator. This limitation makes these methodologies inapplicable to many scenarios. Hence, we develop a novel methodology by extending the mediational g-formula to cover cases with multiple time-varying mediators. We formulate two variants of our approach that are each suited to a distinct set of assumptions and effect definitions and present nonparametric identification results of each variant. We further show how complex causal mechanisms (whose …

Mcl-1 Inhibition: Managing Malignancy In Multiple Myeloma., Omar Al-Odat, Max Von Suskil, Robert Chitren, Weam Elbezanti, Sandeep Srivastava, Tulin Budak-Alpddogan, Subash C. Jonnalagadda, Bharat Aggarwal, Manoj Pandey

College of Science & Mathematics Departmental Research

Multiple myeloma (MM) is a plasma cells neoplasm. The overexpression of Bcl-2 family proteins, particularly myeloid cell leukemia 1 (Mcl-1), plays a critical role in the pathogenesis of MM. The overexpression of Mcl-1 is associated with drug resistance and overall poor prognosis of MM. Thus, inhibition of the Mcl-1 protein considered as a therapeutic strategy to kill the myeloma cells. Over the last decade, the development of selective Mcl-1 inhibitors has seen remarkable advancement. This review presents the critical role of Mcl-1 in the progression of MM, the most prominent BH3 mimetic and semi-BH3 mimetic that selectively inhibit Mcl-1, and …

Developing Pandemic Comics For Youth Audiences, Judy Diamond, Amy Spiegel, Patricia Wonch Hill, Elizabeth Vanwormer, Judi M. Gaiashkibos, Bob Hall, Aaron Sutherlen, Julia Mcquillan

University of Nebraska State Museum: Staff and Affiliates, Publications

In spring 2020 our team received funding from the Rapid Response Research program of the National Science Foundation to develop comics that would help youth understand the COVID-19 pandemic. Our project built on a decade of expertise creating comics about the biology of viruses. In collaboration with virologists and artists, we developed three comic stories about COVID-19 during the pandemic and posted them on-line during the last half of 2020. The fictional narratives address fundamental issues in biology, virology, and network science, in order to help readers understand the complexities of living through a viral pandemic. The stories focus on …

Development Of A Fixed Module Repertoire For The Analysis And Interpretation Of Blood Transcriptome Data., Matthew C Altman, Darawan Rinchai, Nicole Baldwin, Mohammed Toufiq, Elizabeth Whalen, Mathieu Garand, Basirudeen Syed Ahamed Kabeer, Mohamed Alfaki, Scott R Presnell, Prasong Khaenam, Aaron Ayllón-Benítez, Fleur Mougin, Patricia Thébault, Laurent Chiche, Noemie Jourde-Chiche, J Theodore Phillips, Goran Klintmalm, Anne O'Garra, Matthew Berry, Chloe Bloom, Robert J Wilkinson, Christine M Graham, Marc Lipman, Ganjana Lertmemongkolchai, Davide Bedognetti, Rodolphe Thiebaut, Farrah Kheradmand, Asuncion Mejias, Octavio Ramilo, Karolina Palucka, Virginia Pascual, Jacques Banchereau, Damien Chaussabel

Faculty Research 2021

As the capacity for generating large-scale molecular profiling data continues to grow, the ability to extract meaningful biological knowledge from it remains a limitation. Here, we describe the development of a new fixed repertoire of transcriptional modules, BloodGen3, that is designed to serve as a stable reusable framework for the analysis and interpretation of blood transcriptome data. The construction of this repertoire is based on co-clustering patterns observed across sixteen immunological and physiological states encompassing 985 blood transcriptome profiles. Interpretation is supported by customized resources, including module-level analysis workflows, fingerprint grid plot visualizations, interactive web applications and an extensive annotation …

Saving The Last Unicorns: The Genetic Rescue Of Florida’S Pillar Corals, Karen L. Neely, Cynthia L. Lewis, Keri O’Neil, Cheryl M. Woodley, Jennifer Moore, Zach Ransom, Amelia Moura, Ken Nedimyer, David Vaughan

Marine & Environmental Sciences Faculty Articles

As stony coral tissue loss disease (SCTLD) swept through the Florida Reef Tract, one of the most severely impacted species was the iconic pillar coral, Dendrogyra cylindrus. As the species’ population experienced a precipitous decline, a collaborative rescue project collected colony fragments for safekeeping at onshore and offshore nursery facilities. Between 2015 and 2019, a total of 574 fragments representing 128 genotypes were collected. These are currently dispersed among five facilities where they continue to provide opportunities to (1) refine best husbandry practices for D. cylindrus, (2) develop treatment options for SCTLD that have been adapted for use …

Structure-Guided Microbial Targeting Of Antistaphylococcal Prodrugs, Justin J. Miller, Ishaan T. Shah, Jayda Hatten, Yasaman Barekatain, Elizabeth A. Mueller, Ahmed M. Moustafa, Rachel L. Edwards, Cynthia S. Dowd, Geoffrey C. Hoops, R Jeremy Johnson

Scholarship and Professional Work - LAS

Carboxy ester prodrugs are widely employed to increase oral absorption and potency of phosphonate antibiotics. Prodrugging can mask problematic chemical features that prevent cellular uptake and may enable tissue-specific compound delivery. However, many carboxy ester promoieties are rapidly hydrolyzed by serum esterases, limiting their therapeutic potential. While carboxy ester-based prodrug targeting is feasible, it has seen limited use in microbes as microbial esterase-specific promoieties have not been described. Here we identify the bacterial esterases, GloB and FrmB, that activate carboxy ester prodrugs in Staphylococcus aureus. Additionally, we determine the substrate specificities for FrmB and GloB and demonstrate the structural basis …

Highly Contiguous Assemblies Of 101 Drosophilid Genomes, Bernard Y. Kim, Jeremy R. Wang, Danny E. Miller, Olga Barmina, Emily Delaney, Ammon Thompson, Aaron A. Comeault, David Peede, Emmanuel R. R. D'Agostino, Julianne Pelaez, Jessica M. Aguilar, Diler Haji, Teruyuki Matsunaga, Ellie E. Armstrong, Molly Zych, Yoshitaka Ogawa, Marina Stamenković-Radak, Mihailo Jelić, Marija Savić Veselinović, Marija Tanasković, Jeremy S. Davis

Biology Faculty Publications

Over 100 years of studies in Drosophila melanogaster and related species in the genus Drosophila have facilitated key discoveries in genetics, genomics, and evolution. While high-quality genome assemblies exist for several species in this group, they only encompass a small fraction of the genus. Recent advances in long-read sequencing allow high-quality genome assemblies for tens or even hundreds of species to be efficiently generated. Here, we utilize Oxford Nanopore sequencing to build an open community resource of genome assemblies for 101 lines of 93 drosophilid species encompassing 14 species groups and 35 sub-groups. The genomes are highly contiguous and complete, …

Summer Research Scholar Tests Effectiveness Of Sunscreens, Gains Lab Experience For Future Career, Office Of University Communications

Gardner-Webb NewsCenter Archive

The Gardner-Webb University Summer Undergraduate Research Scholars Program gives students like Virginia “Ginny” Merrill, of Charleston, S.C., experience that will lead to future discoveries in their careers. Merrill, a chemistry major and French minor, plans to graduate in 2023, attend graduate school and work in cosmetic chemistry.

Highly Contiguous Assemblies Of 101 Drosophilid Genomes, Bernard Y. Kim, Jeremy R. Wang, Danny E. Miller, Olga Barmina, Emily Delaney, Ammon Thompson, Aaron A. Comeault, David Peede, Emmanuel R.R. D’Agostino, Julianne Pelaez, Jessica M. Aguilar, Diler Haji, Teruyuki Matsunaga, Ellie E. Armstrong, Molly Zych, Yoshitaka Ogawa, Marina Stamenković-Radak, Mihailo Jelić, Marija Savić Veselinović, Marija Tanasković, Pavle Erić, Jian Jun Gao, Takehiro K. Katoh, Masanori J. Toda, Hideaki Watabe, Masayoshi Watada, Jeremy S. Davis, Leonie C. Moyle, Giulia Manoli, Enrico Bertolini, Vladimír Košťál, R. Scott Hawley, Aya Takahashi, Corbin D. Jones, Donald K. Price, Noah Whiteman, Artyom Kopp, Daniel R. Matute, Dmitri A. Petrov

Life Sciences Faculty Research

Over 100 years of studies in Drosophila melanogaster and related species in the genus Drosophila have facilitated key discoveries in genetics, genomics, and evolution. While high-quality genome assemblies exist for several species in this group, they only encompass a small fraction of the genus. Recent advances in long-read sequencing allow high-quality genome assemblies for tens or even hundreds of species to be efficiently generated. Here, we utilize Oxford Nanopore sequencing to build an open community resource of genome assemblies for 101 lines of 93 drosophilid species encompassing 14 species groups and 35 sub-groups. The genomes are highly contiguous and complete, …

Government As The First Investor In Biopharmaceutical Innovation: Evidence From New Drug Approvals 2010–2019, Ekaterina Galkina Cleary, Matthew J. Jackson, Fred D. Ledley

Natural & Applied Sciences Faculty Publications

The discovery and development of new medicines classically involves a linear process of basic biomedical research to uncover potential targets for drug action, followed by applied, or translational, research to identify candidate products and establish their effectiveness and safety.

This Working Paper describes the public sector contribution to that process by tracing funding from the National Institutes of Health (NIH) related to published research on each of the 356 new drugs approved by the U.S. Food and Drug Administration from 2010-2019 as well as research on their 218 biological targets.

Improved Forest Management As A Natural Climate Solution: A Review, Lilli Kaarakka, Meredith Cornett, Grant Domke, Todd A. Ontl, Laura E. Dee

Michigan Tech Publications, Part 1

Natural climate solutions (NCS), a set of land management, conservation and restoration practices aimed at mitigating climate change, have been introduced as cost-effective strategies to increase carbon (C) sequestration in terrestrial ecosystems. Improved forest management (IFM) has been identified as one NCS for working forests with substantial climate change mitigation potential. However, there is a disconnect between the policy and carbon markets context and the scientific evidence for verifiable C benefits. Further, forest soil C—the largest forest C pool—has largely been excluded from current forest management guidelines and has not been included in the IFM discourse. Herein, we assess the …

Chinches, Kelly Kopp, Ryan Davis, Ricardo Ramirez, Celina Wille

All Current Publications

Las chinches son “chinches verdaderas”. En Utah, la chinche común [Blissus leucopterus leucopterus (Say)] y la chinche occidental (Blissus occiduus) pueden alimentarse del césped, especialmente en condiciones de calor intenso y sequía. La falta de riego, junto a la radiación directa y la acumulación de material vegetal muerto puede elevar el número de chinches desde mediados del verano hasta principios del otoño.

Overcoming Obstacles In Protein Expression In The Yeast Pichia Pastoris: Interviews Of Leaders In The Pichia Field, Zoe Ingram, Abha Patkar, Dahoon Oh, Kevin K. Zhang, Christina Chung, Joan Lin-Cereghino, Geoff P. Lin-Cereghino

Pacific Journal of Health

The yeast Pichia pastoris (also known as Komagataella pastoris) has been used for over 30 years to produce thousands of valuable, heterologous proteins, such as insulin to treat diabetes and antibodies to prevent migraine headaches. Despite its success, there are some common, stubborn problems encountered by research scientists when they try to use the yeast to produce their recombinant proteins. In order to provide those working in this field with strategies to overcome these common obstacles, nine experts in P. pastoris protein expression field were interviewed to create a written review and video (https://www.youtube.com/watch?v=FyC9xXVLyD0). This review describes …

Cross-National Analysis Of Mothers' Occupational Status In Germany And The United States: Before And After Germany's Work-Family Policy Changes, Paige N. Park

Theses and Dissertations

In many OECD countries, women are underrepresented in the highest status, highest paying positions and overrepresented in the lowest status, lowest paying positions. One potential reason for this inequity is the "motherhood penalty," where women with children face more roadblocks in hiring and promotions. This research investigates occupational segregation among mothers and fathers and analyzes whether gender gaps in occupational status are more extreme for immigrant populations. Using data from the Luxembourg Cross-National Data Center, I compare changes in gender occupational segregation from 2000 to 2016 in Germany and the United States among immigrant and native-born parents. Multinomial logistic regression …

A Large-Scale Experiment Finds No Evidence That A Seismic Survey Impacts A Demersal Fish Fauna, Mark G. Meekan, Conrad W. Speed, Robert D. Mccauley, Rebecca Fisher, Matthew J. Birt, Leanne M. Currey-Randall, Jayson M. Semmens, Stephen J. Newman, Katherine Cure, Marcus Stowar, Brigit Vaughan, Miles J G Parsons

Fisheries Research Articles

Seismic surveys are used to locate oil and gas reserves below the seabed and can be a major source of noise in marine environments. Their effects on commercial fisheries are a subject of debate, with experimental studies often producing results that are difficult to interpret. We overcame these issues in a large-scale experiment that quantified the impacts of exposure to a commercial seismic source on an assemblage of tropical demersal fishes targeted by commercial fisheries on the North West Shelf of Western Australia. We show that there were no short-term (days) or long-term (months) effects of exposure on the composition, …

Hopes And Dreams, University Of Dayton

Materials from the University of Dayton Magazine Website

Members of the Class of 2021 write out their hopes and dreams.

Molecular Diagnosis Of Sars-Cov-2: Assessing And Interpreting Nucleic Acid And Antigen Tests, Peter A. Zimmerman, Christopher L. King, Mahmoud Ghannoum, Robert A. Bonomo, Gary W. Procop

Faculty Scholarship

In this review, we summarize the current status of nucleic acid and antigen testing required for diagnosing SARS-CoV-2 infection and COVID-19 disease. Nucleic acid amplification (NAAT) and antigen-detection (Ag) tests occupy a critically important frontline of defense against SARS-CoV-2 in clinical and public health settings. In early stages of this outbreak, we observed that identifying the causative agent of a new illness of unknown origin was greatly accelerated by characterizing the nucleic acid signature of the novel coronavirus. Results from nucleic acid sequencing led to the development of highly sensitive RT-PCR testing for use in clinical settings and to informing …

Elevated S-Adenosylhomocysteine Induces Adipocyte Dysfunction To Promote Alcohol-Associated Liver Steatosis, Madan Kumar Arumugam, Srinivas Chava, Karuna Rasineni, Matthew C. Paal, Terrence Donohue, Natalia A. Osna, Kusum K. Kharbanda

Journal Articles: Internal Medicine

It has been previously shown that chronic ethanol administration-induced increase in adipose tissue lipolysis and reduction in the secretion of protective adipokines collectively contribute to alcohol-associated liver disease (ALD) pathogenesis. Further studies have revealed that increased adipose S-adenosylhomocysteine (SAH) levels generate methylation defects that promote lipolysis. Here, we hypothesized that increased intracellular SAH alone causes additional related pathological changes in adipose tissue as seen with alcohol administration. To test this, we used 3-deazaadenosine (DZA), which selectively elevates intracellular SAH levels by blocking its hydrolysis. Fully differentiated 3T3-L1 adipocytes were treated in vitro for 48 h with DZA and analysed for …

From Reaction Kinetics To Dementia: A Simple Dimer Model Of Alzheimer’S Disease Etiology, Michael R. Lindstrom, Manuel B. Chavez, Elijah A. Gross-Sable, Eric Y. Hayden, David B. Teplow

School of Mathematical & Statistical Sciences Faculty Publications

Oligomers of the amyloid β-protein (Aβ) have been implicated in the pathogenesis of Alzheimer’s disease (AD) through their toxicity towards neurons. Understanding the process of oligomerization may contribute to the development of therapeutic agents, but this has been difficult due to the complexity of oligomerization and the metastability of the oligomers thus formed. To understand the kinetics of oligomer formation, and how that relates to the progression of AD, we developed models of the oligomerization process. Here, we use experimental data from cell viability assays and proxies for rate constants involved in monomerdimer-trimer kinetics to develop a simple mathematical model …

Do Psychiatric Diseases Follow Annual Cyclic Seasonality?, Hanxin Zhang, Atif Khan, Henrik Larsson, Andrey Rzhetsky

Student Publications

Seasonal affective disorder (SAD) famously follows annual cycles, with incidence elevation in the fall and spring. Should some version of cyclic annual pattern be expected from other psychiatric disorders? Would annual cycles be similar for distinct psychiatric conditions? This study probes these questions using 2 very large datasets describing the health histories of 150 million unique U.S. citizens and the entire Swedish population. We performed 2 types of analysis, using "uncorrected" and "corrected" observations. The former analysis focused on counts of daily patient visits associated with each disease. The latter analysis instead looked at the proportion of disease-specific visits within …

Week Of July 19, 2021, New York Medical College

InTouch

• MSCHE Reaffirms NYMC Accreditation for Maximum Term of Eight Years
• Vice Chancellor Mill Etienne, M.D. '02, M.P.H., FAAN, FAES, Honored at Crain's New York Inaugural Excellence in Diversity and Inclusion Awards
• Office of Security is Renamed to the Office of Public Safety
• SOM Welcomes New Slate of Officers to Student Senate E-Board
• Join NYMC and TCUS for the Thirteenth Symposium in the COVID-19 Series
• Chancellor Hosts Virtual Town Hall Meeting
• HSL Offers EndNote II: Advanced Class
• Chancellor Halperin Shares his Thoughts on Space Tourism

A Single Cell Transcriptomics Map Of Paracrine Networks In The Intrinsic Cardiac Nervous System., Alison Moss, Shaina Robbins, Sirisha Achanta, Lakshmi Kuttippurathu, Scott Turick, Sean Nieves, Peter Hanna, Elizabeth H. Smith, Donald B. Hoover, Jin Chen, Zixi Jack Cheng, Jeffrey L. Ardell, Kalyanam Shivkumar, James S. Schwaber, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

We developed a spatially-tracked single neuron transcriptomics map of an intrinsic cardiac ganglion, the right atrial ganglionic plexus (RAGP) that is a critical mediator of sinoatrial node (SAN) activity. This 3D representation of RAGP used neuronal tracing to extensively map the spatial distribution of the subset of neurons that project to the SAN. RNA-seq of laser capture microdissected neurons revealed a distinct composition of RAGP neurons compared to the central nervous system and a surprising finding that cholinergic and catecholaminergic markers are coexpressed, suggesting multipotential phenotypes that can drive neuroplasticity within RAGP. High-throughput qPCR of hundreds of laser capture microdissected …