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Reconstruction Of The Austronesian Diaspora In The Era Of Genomics, Geoffrey K. Chambers, Hisham A. Edinur

Human Biology Open Access Pre-Prints

The Austronesian Diaspora is a 5000-year account of how a small group of Taiwanese farmers expanded to occupy territories reaching halfway round the world. Reconstructing their detailed history has spawned many academic contests across many disciplines. An outline orthodox version has eventually emerged, but still leaves many unanswered questions. The remarkable power of whole-genome technology has now been applied to people across the entire region. This review gives an account of this era of genetic investigation and discusses its many achievements including revelation in detail of many unexpected patterns of population movement and the significance of this information for medical …

Type Ii Photosensitized Oxidation In Senescent Microalgal Cells At Different Latitudes: Does Low Under-Ice Irradiance In Polar Regions Enhance Efficiency?, Jean François Rontani, Rémi Amiraux, Lukas Smik, Stuart G. Wakeham, Aurélien Paulmier, Frédéric Vaultier, Ha Sun-Yong, Min Jun-Oh, Simon T. Belt

School of Geography, Earth and Environmental Sciences

No abstract provided.

What Is Biochar And How Is It Used?, Marion Murray

All Current Publications

Biochar is a charcoal-like product that contains no petroleum. It is made by heating biomass such as herbaceous or woody crop residues, non-salvageable timber, and slash, or animal manure, in a contained system. There are many potential uses for biochar including water treatment, land reclamation, and carbon sequestration. Biochar may also be used as a soil amendment for two purposes – to improve plant health and to store carbon.

Tick Saliva And The Alpha-Gal Syndrome: Finding A Needle In A Haystack, Surendra Raj Sharma, Shahid Karim

Faculty Publications

Ticks and tick-borne diseases are significant public health concerns. Bioactive molecules in tick saliva facilitate prolonged blood-feeding and transmission of tick-borne pathogens to the vertebrate host. Alpha-gal syndrome (AGS), a newly reported food allergy, is believed to be induced by saliva proteins decorated with a sugar molecule, the oligosaccharide galactose-⍺-1,3-galactose (α-gal). This syndrome is characterized by an IgE antibody-directed hypersensitivity against α-gal. The α-gal antigen was discovered in the salivary glands and saliva of various tick species including, the Lone Star tick (Amblyomma americanum). The underlying immune mechanisms linking tick bites with α-gal-specific IgE production are poorly understood and are …

Collaborative Research: Ecological Legacy Effects Of Megacarcasses In African Savanna Ecosystems, Johan Du Toit

Funded Research Records

No abstract provided.

Study On Universal Characteristics Of Insect Population Ecological Network, Guilan Luo, Hongjun Hao, Wang Xiao, Zhang Mei

Journal of System Simulation

Abstract: In order to evaluate the current state of insect ecological development in Erhai wetland, complex network theory is used to construct a topological structure model of insect ecological network with insect populations as network nodes and correlations as edges. By analyzing the characteristic parameters of the model, it is concluded that the insect ecological network conforms to the characteristics of small world and scale-free network, and the node degree distribution obeys the power law distribution. The method of destroying the topology is used to simulate the dynamic evolution of the network ecology. The study shows that the disappearance of …

Transmission Process Prediction Of Novel Coronavirus Based On System Dynamics, Xuepeng Lu, Shang Jiao, Junhui Zhao, Lulu Lü, Zhou Li

Journal of System Simulation

Abstract: The transmission characteristics of novel coronavirus is considered and a new SE4IR2 model based on the principle of system dynamics is proposed. The US epidemic data from June to November is used to set the isolation rate and other parameters, and the SE4IR2 model is used to fit, analyze and predict the development of the epidemic trend in the next stage. The empirical part uses the data from June to November in the United States to achieve the parameters of the SE4IR2 model, obtains the parameter values in December and January through the time series prediction model, and compares …

Retinoids As Chemo-Preventive And Molecular-Targeted Anti-Cancer Therapies., Victoria O. Hunsu, Caroline O.B. Facey, Jeremy Z. Fields, Bruce M. Boman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Retinoic acid (RA) agents possess anti‐tumor activity through their ability to induce cellular differentiation. However, retinoids have not yet been translated into effective systemic treatments for most solid tumors. RA signaling is mediated by the following two nuclear retinoic receptor subtypes: the retinoic acid receptor (RAR) and the retinoic X receptor (RXR), and their isoforms. The identification of mutations in retinoid receptors and other RA signaling pathway genes in human cancers offers opportunities for target discovery, drug design, and personalized medicine for distinct molecular retinoid subtypes. For example, chromosomal translocation involving RARA occurs in acute promyelocytic leukemia (APL), and all‐trans …

Aducanumab: Appropriate Use Recommendations, Jeffrey Cummings, P. Aisen, L. G. Apostolova, A. Atri, S. Salloway, M. Weiner

School of Medicine Faculty Research

Aducanumab has been approved by the US Food and Drug Administration for treatment of Alzheimer’s disease (AD). Clinicians require guidance on the appropriate use of this new therapy. An Expert Panel was assembled to construct Appropriate Use Recommendations based on the participant populations, conduct of the pivotal trials of aducanumab, updated Prescribing Information, and expert consensus. Aducanumab is an amyloid-targeting monoclonal antibody delivered by monthly intravenous infusions. The pivotal trials included patients with early AD (mild cognitive impairment due to AD and mild AD dementia) who had confirmed brain amyloid using amyloid positron tomography. The Expert Panel recommends that use …

Covid-19 Newsletter (Vol. 81), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Structural And Biochemical Characterization Of The Flavin-Dependent Siderophore-Interacting Protein From Acinetobacter Baumannii, Hannah Valentino, David A. Korasick, Tabbetha J. Bohac, Justin A. Shapiro, Timothy A. Wencewicz, John J. Tanner, Pablo Sobrado

Chemistry Faculty Research & Creative Works

Acinetobacter baumannii is an opportunistic pathogen with a high mortality rate due to multi-drug-resistant strains. The synthesis and uptake of the iron-chelating siderophores acinetobactin (Acb) and preacinetobactin (pre-Acb) have been shown to be essential for virulence. Here, we report the kinetic and structural characterization of BauF, a flavin-dependent siderophore-interacting protein (SIP) required for the reduction of Fe (III) bound to Acb/pre-Acb and release of Fe(II). Stopped-flow spectrophotometric studies of the reductive half-reaction show that BauF forms a stable neutral flavin semiquinone intermediate. Reduction with NAD(P)H is very slow (kobs, 0.001 s-1) and commensurate with the rate of reduction by photobleaching, …

Plasma Agriculture: Characterization Of Dbd Plasma Jet And Analysis Of Effects When Treated On Sweet Basil (Ocimum Basilicum), William Davis

Seton Hall University Dissertations and Theses (ETDs)

Plasma agriculture is an increasingly diverse field, where effects of nonthermal or cold plasma are measured by their influence on plant physiology and growth rate. Effects range from sterilization, germination, increased growth rate, cell metabolism, and so forth. This study aims to investigate the understanding of the generation of specific reactive oxygen and nitrogen species (RONS) from a nonthermal atmospheric DBD helium-based plasma jet and identify quantifiable effects that can directly translate to different applications related to plasma agriculture. Basil plants were separated into treated and control groups and grown hydroponically. The treated plants received a 30 second exposure treatment …

A Comparative Study Between Conventional Vmat-Total Body Irradiation (Tbi) And Vmat Simultaneous Integrated Marrow Boost (Sib) Tbi To Determine Dosimetric Feasibility In Pediatric Patients, Candace R. Ray

Masters Projects

Introduction

Total body irradiation (TBI) plays a critical role in the myeloablative conditioning regimen for stem cell transplantations due to its ability to deliver dose to all tissues including sanctuary sites, giving an opportunity for cure in children suffering a relapse of leukemia. VMAT-TBI techniques have become the standard practice, but toxic doses to organs at risk (OARs) can lead to long-term complications, particularly in children who are living longer as cure rates improve. The purpose of this study is to demonstrate the feasibility of a simultaneous integrated boost (SIB) TBI technique to deliver a sufficient dose to the marrow, …

Rational Examination Of Cultivation Of Talent Reserve For Scientific And Technological Innovation In China, Yonghe Zhang, Jingying Wang, Xinying Li, Xuanyang Yang, Yong Xie

Bulletin of Chinese Academy of Sciences (Chinese Version)

It is an important guarantee for China to win the first chance in the future international competition to vigorously cultivate the talent reserve of scientific and technological innovation. This study first proposes that China urgently needs to pay attention to the early training of scientific and technological innovation talents from the international situation, existing policies, and the current educational situation. Then it dynamically examines the training theory and practical experience of scientific and technological innovation talent reserve from an international perspective, and further considers the critical understanding and key issues of early training. Finally, some suggestions are given on the …

Science Education In Post-Covid-19 Era, Su Wang, Yeliija Yuan

Bulletin of Chinese Academy of Sciences (Chinese Version)

It is a consensus worldwide that COVID-19 has made far-reaching impact on education. As one of the essential topics of discussion for Education 4.0, science education has been paid lots of attention focusing on its further development especially under the background of the fourth industrial revolution and Post-COVID-19 era. This research proposes developing strategies of science education in the Post-COVID-19 era with a globalized vision. The strategies, proposed on the basis of worldwide research outcome of science education and the analysis of China's actual conditions, include developing the top layer design for science education from national security perspectives, establishing a …

Comparative Study On Development Of Science Education Worldwide: Advance In Ideas, Themes And Practice, Xinning Pei, Tainian Zheng

Bulletin of Chinese Academy of Sciences (Chinese Version)

The importance of science education lies not in delivering factual knowledge to learners, but in using knowledge as a way for them to know the world and cope with the uncertainty. The development of science education worldwide in the 21st century presents the following themes:the sustainable development of human beings as the main context, cultivating scientific literacy as the goal, paying attention to understanding the nature of science, building a "common foundation" for science learning through in-depth and coherent curriculum, using information technology to stimulate and integrate science education innovation, emphasizing the unity of science and humanities, giving full play …

From Strategy Consulting Research To Science Of Think Tank, Xin Wang, Huiqin Zhang, Changpu Sun

Bulletin of Chinese Academy of Sciences (Chinese Version)

Think tank researches are the main element to advance the modernization of China's capacity for governance, and they are multidisciplinary related to many research areas. The suggestions of think tank researches may have massive influences as long as they are adapted. In this study, we recommend that the think tank researches should be advanced to the science of think tank. The think tank researches should follow the widely recognized scientific research character-falsifiability. Based on solid data and evidences, think tank researches build objective models, develop qualitative methods and quantitative tools, and generate objective strategic consulting proposals with predictive ability. By …

Lake Superior Has Lost Over 90% Of Its Pesticide Hch Load Since 1986, Terry F. Bidleman, Sean Backus, Alice Dove, Rainer Lohmann, Derek Muir, Camilla Teixeira, Liisa Jantunen

Graduate School of Oceanography Faculty Publications

The time trend of α- and γ-hexachlorocyclohexane (HCH) isomers in Lake Superior water was followed from 1986 to 2016, the longest record for any persistent organic pollutant (POP) in Great Lakes water. Dissipation of α-HCH and γ-HCHs was first order, with halving times (t1/2) of 5.7 and 8.5 y, respectively. Loss rates were not significantly different starting a decade later (1996-2016). Concentrations of β-HCH were followed from 1996-2016 and dissipated more slowly (t1/2 = 16 y). In 1986, the lake contained an estimated 98.8 tonnes of α-HCH and 13.2 tonnes of γ-HCH; by 2016, only 2.7% and 7.9% of 1986 …

Led Excitation Of Thermographic Phosphors For Surface Temperature Analysis On Tissue And Flexible Ceramics., Atul Raj Regmi

Electronic Theses and Dissertations Archive

Phosphor thermometry offers many advantages over other temperature sensing techniques and is firmly established as a superior technique when compared to others such as infrared and resistive heating methods. The aim of the present work is to extend the application range of phosphor thermometry by exploring the feasibility of two new areas. In the first assessment, the temperature of tissue was evaluated by directly and indirectly interfacing thermographic phosphors with tissue. In the indirect method the temperature evaluated was the result of joule heating that occurred in a current carrying electrode mimicking an implant. The current was supplied by a …

Age-Dependent Effects Of Social Isolation On Mesolimbic Dopamine Release, Megan Alyse Mcwain

Electronic Theses and Dissertations Archive

Social isolation is a prevalent public health risk factor for depression and substance abuse. Considering modern society’s challenge with subjective and objective isolation, it is imperative to research its effects on the mesolimbic dopamine system, a neural pathway thought to modulate behaviors related to substance use disorder and depression. Further, particular interest is on the effect of social isolation across age groups on mesolimbic dopamine release, particularly for the vulnerable populations of adolescents and the elderly. This study measured the variables of stimulation-evoked baseline dopamine release, baseline dopamine half-life, autoreceptor mediated inhibition, and response to cocaine utilizing fixed potential amperometry …

Period Of Marriage And Genetic Similarity In Height Between Spouses In The United States Over The 20th Century, Yi Li, Guang Guo

Human Biology Open Access Pre-Prints

Social norms regarding who marries whom have changed dramatically in the United States across the 20th century. These changes may influence the level of genetic similarity between spouses. This study investigates whether genetic similarity in height between husband and wife was influenced by a historical transition in spouse selection criteria, the transition from the companionate marriage to the individualized marriage, a great transition occurred in the 1960s. In the companionate marriage, husband and wife chose each other as companions, and the emphasis was on playing marital roles well: husbands being good breadwinners and wives being good homemakers. In the individualized …

Lysmd3: A Mammalian Pattern Recognition Receptor For Chitin, Xin He, Brad A. Howard, Yang Liu, Aaron K. Neumann, Liwu Li, Nidhi Menon, Tiffany Roach, Shiv D. Kale, David C. Samuels, Hongyan Li, Trenton Kite, Hirohito Kita, Tony Y. Hu, Mengyao Luo, Caroline N. Jones, Uju Joy Okaa, Diane L. Squillace, Bruce S. Klein, Christopher B. Lawrence

Pathology Research and Scholarship

Chitin, a major component of fungal cell walls, has been associated with allergic disorders such as asthma. However, it is unclear how mammals recognize chitin and the principal receptor(s) on epithelial cells that sense chitin remain to be determined. In this study, we show that LYSMD3 is expressed on the surface of human airway epithelial cells and demonstrate that LYSMD3 is able to bind chitin, as well as β-glucan, on the cell walls of fungi. Knockdown or knockout of LYSMD3 also sharply blunts the production of inflammatory cytokines by epithelial cells in response to chitin and fungal spores. Competitive inhibition …

Effects Of Wetland Management And Associated Abiotic Factors On Rare Plant Communities Of Spring-Fed Arid Wetlands, Antonio Cantu De Leija

LSU Master's Theses

Spring-fed arid wetlands support high biological productivity and are hotspots for endemism and distribution of rare plants, making them areas of high conservation value. These systems are driven by complex interactions among groundwater discharge and the geomorphic and climatic features of the setting, which provide gradients of edaphic conditions, particularly soil moisture and salinity that influence the presence and abundance of rare plant communities. However, spring-fed arid wetlands are at particular risk of increases in salinity and drier hydrological regimes due to anthropogenic activities. Such alterations to abiotic conditions may jeopardize the distribution and abundance of rare plants by exceeding …

Optimization Of Mechanical Properties At The Infarct Border Zone, Kaushik Sunder

LSU Master's Theses

A myocardial infarction (MI) occurs every 39 seconds in the United States. As of 2016, an estimated 550,000 new and 200,000 recurrent episodes of myocardial infarction (MI) occur each year in the United States was. Infarction is often distinguished by a considerable decrease in wall thickness and an increase in heart size or left ventricular volume. This behavior happens when there is a prolonged lack of blood flow, usually due to damage or clotting, which causes cardiomyocytes to die (CMs). The development of non-contractile infarct scarring is the primary pathophysiology of MI. While the infarct scar prevents myocardial rupture during …

Full Issue: Volume 2, Issue 2, Editorial Board

Swarthmore Undergraduate History Journal

The second issue in the second volume of the Swarthmore Undergraduate History Journal.

“Unspoken Understanding”: The Evolution Of Chinese American Adoption Communities, Annie Abruzzo

Swarthmore Undergraduate History Journal

While scholarly work on adoption, transnational adoption, and specifically international adoption from China has been robust, it has tended to focus on studying parents and parenting. This paper analyzes the resources used by both parents and children to discuss race, culture, and adoption, and seeks to understand the effects of these parenting strategies on Chinese American adoptees, who have begun to reach young adulthood in the last ten years. Examination of the recent growth of adoptee communities reveals that a shared and complex adoptee identity is a more powerful nexus than shared Chineseness.

Sisterhood & Feminism: Engaging Gender And Women’S Studies Students In The Community, Angela Clark-Taylor, Jane L. Bryant, Susan Storey, Julianne Lawlor Nigro

The Seneca Falls Dialogues Journal

No abstract provided.

Unusual Subjects: Finding Model Communities Among Marginalized Populations, Babette Faehmel Ph.D., Tiombe Farley, Vashti Ma'at

The Seneca Falls Dialogues Journal

Unusual subjects:

Finding model communities among marginalized populations

This paper is inspired by the questions that we have asked ourselves since we first met at Schenectady County Community College. What is it, we wondered, that keeps so many of our fellow Americans seemingly wedded to a political economy that is sustainable only at great cost? Could we use our academic work to help spread awareness about people who dared to demand different lives? And might our studies suggest strategies to work for change?

We currently all pursue different projects, but we share a belief that one obstacle to progressive change …

Confronting Student Resistance To Ecofeminism: Three Perspectives, Jennifer Browdy De Hernandez, Holly Kent, Colleen Martell

The Seneca Falls Dialogues Journal

Teaching ecofeminism is a dynamic, vital practice, demanding a great deal of both educators and students. At the heart of this essay is the question: how can we teach ecofeminism effectively? In this work, we reflect on our successes and failures teaching ecofeminism within various topics and in different settings. While each co-author of this piece brings ecofeminism into our classrooms, we do so in very different ways and have diverse approaches to making ecofeminist theories and ideas feel vital, necessary, and relevant for our students. In our essay, we aim to offer some productive and provocative suggestions and ideas …

The Seneca Falls Dialogues Journal, V. 1, Issue 1 (Complete Issue), Barbara Lesavoy, Deborah Uman

The Seneca Falls Dialogues Journal

We are thrilled to introduce the inaugural edition of The Seneca Falls Dialogues Journal. This multidisciplinary, peer-reviewed, online journal grows out of the Biennial Seneca Falls Dialogues (SFD), a biennial conference launched in October 2008 to celebrate the 160th anniversary of the first women’s rights convention held in Seneca Falls, New York and the 60th anniversary of Eleanor Roosevelt’s Universal Declaration of Human Rights. The Seneca Falls Dialogues Journal volume I draws from the 2014 SFD conference theme, "Ecofeminism: Cultivating Place and Identity", which was highlighted in the keynote address by BLK ProjeK founder and Eco-Warrior, Tanya Fields.

Contents …