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Genetic, Social And Behavioral Risk Factors Associated With Alzheimer’S Disease, Vineela Nagamalla, Jay Patel, Mir Saleem

Biology Faculty Articles

Alzheimer’s disease (AD) is a neurodegenerative condition which consists of stages of mental, memory, and cognitive decline. As it continues to stand as the sixth leading cause of death in the U.S., 44 million people worldwide are affected. The objective of this paper is to explore the risk factors for AD in an attempt to examine potential causes for the incidence of AD. We examined genetics, lifestyle, and pre-existing conditions as risk factors for AD. We found that there are various alleles, such as APP, PSEN, ADAM, APOE, and TREM2, that play a role in the development of AD. It …

Lncrna Nonhsat069381 And Nonhsat140844 Increase In Aging Human Blood, Regulating Cardiomyocyte Apoptosis., Jinyang Zhao, Xiaolong Lin, Haoxuan Sun, Donghui Zhao, Qin Ma, Wayne Bond Lau, Zichao Cheng, Fanqi Li, Jinghua Liu, Qian Fan

Department of Emergency Medicine Faculty Papers

Aging augments postischemic apoptosis via incomplete mechanisms. Our previous animal study suggests that in addition to proapoptotic effects, lncRNAs also exert antiapoptotic effects in cardiomyocytes. However, whether this unexpected phenomenon exists in humans is unknown. In the present study, we investigated the relationship between aging and apoptosis regulation in human blood samples and confirmed their role by utilizing the cardiomyocyte lines (AC16 cells). Human blood samples were collected from 20 pairs of older adult and young volunteers. Age-different apoptotic regulatory lncRNAs and miRNAs were identified by microarray and bioinformatics analysis. The results indicated that lncRNA (NONHSAT069381 and NONHSAT140844) and miRNA …

The Evolution Of Dietary Adaptations In Small Mammals: From Muscles To Microbes, Mark Thomas Swanson

LSU Doctoral Dissertations

My dissertation provides critical insights on the pattern and process of evolution in front-end and back-end dietary adaptations of mammals. I found that the position of the rodent masseter muscle, a complex front-end adaptation that improves the efficiency of mechanical digestion, has convergently evolved numerous times, suggesting that selective pressure for this adaptation has been strong. For back-end adaptations, I found gut bacterial taxa that likely aid in chemical digestion of food have predictable associations with host diet across host species in natural environments. To detect patterns in gut microbial community structure that are related to host factors such as …

Crosstalk Between Dysfunctional Mitochondria And Inflammation In Glaucomatous Neurodegeneration, Assraa Hassan Jassim, Denise M. Inman, Claire H. Mitchell

Health & Biomedical Sciences Faculty Publications

Mitochondrial dysfunction and excessive inflammatory responses are both sufficient to induce pathology in age-dependent neurodegenerations. However, emerging evidence indicates crosstalk between damaged mitochondrial and inflammatory signaling can exacerbate issues in chronic neurodegenerations. This review discusses evidence for the interaction between mitochondrial damage and inflammation, with a focus on glaucomatous neurodegeneration, and proposes that positive feedback resulting from this crosstalk drives pathology. Mitochondrial dysfunction exacerbates inflammatory signaling in multiple ways. Damaged mitochondrial DNA is a damage-associated molecular pattern, which activates the NLRP3 inflammasome; priming and activation of the NLRP3 inflammasome, and the resulting liberation of IL-1β and IL-18 via the gasdermin …

Seasonal Cycling Of Zinc And Cobalt In The South-Eastern Atlantic Along The Geotraces Ga10 Section, Neil J. Wyatt, Angela Milne, Eric P. Achterberg, Thomas J. Browning, Heather A. Bouman, E. Malcolm S. Woodward, Maeve C. Lohan

School of Geography, Earth and Environmental Sciences

Abstract. We report the distributions and stoichiometry of dissolved zinc (dZn) and cobalt (dCo) in sub-tropical and sub-Antarctic waters of the south-eastern Atlantic Ocean during austral spring 2010 and summer 2011/2012. In sub-tropical surface waters, mixed-layer dZn and dCo concentrations during early spring were 1.60 ± 2.58 nM and 30 ± 11 pM, respectively, compared with summer values of 0.14 ± 0.08 nM and 24 ± 6 pM. The elevated spring dZn concentrations resulted from an apparent offshore transport of elevated dZn at depths between 20–55 m, derived from the Agulhas Bank. In contrast, open-ocean sub-Antarctic surface waters displayed largely …

Distinct Cortical Systems Reinstate The Content And Context Of Episodic Memories., James E. Kragel, Youssef Ezzyat, Bradley C. Lega, Michael R. Sperling, Gregory A. Worrell, Robert E. Gross, Barbara C. Jobst, Sameer A. Sheth, Kareem A. Zaghloul, Joel M. Stein, Michael J. Kahana

Department of Neurology Faculty Papers

Episodic recall depends upon the reinstatement of cortical activity present during the formation of a memory. Evidence from functional neuroimaging and invasive recordings in humans suggest that reinstatement organizes our memories by time or content, yet the neural systems involved in reinstating these unique types of information remain unclear. Here, combining computational modeling and intracranial recordings from 69 epilepsy patients, we show that two cortical systems uniquely reinstate the semantic content and temporal context of previously studied items during free recall. Examining either the posterior medial or anterior temporal networks, we find that forward encoding models trained on the brain's …

Second-Career Ms2s Learn From Oncology And Survivorship Expert Through Cares; Use Prior Experience To Guide Current Research, Mary Ashley Canevaro

Browse All News

No abstract provided.

Little Wasps On The Fringes, Jeremy Hummel

Faculty Work Comprehensive List

"As image-bearers of God, mandated to tend and care for his creation, we can welcome his creation into our human landscapes in a mutually flourishing way."

Posting about ­­­­­­­­the wonders of creation from In All Things - an online journal for critical reflection on faith, culture, art, and every ordinary-yet-graced square inch of God’s creation.

https://inallthings.org/little-wasps-on-the-fringes/

The Minatory Minotaur: Demythologizing Myth In “The House Of Asterion”, Evan Chiovari

The Pegasus Review: UCF Undergraduate Research Journal

Recent critics of Jorge Luis Borges’s “The House of Asterion” (1947) have traced the author’s revisions in the original manuscript, charting his changing arrangement of information through the text. This essay investigates the information itself through structuralist and historicist theory. A structuralist reading analyzes Asterion’s worldview and shows how various narrators dock the integrity of his voice. Historicism probes aspects of religion, biology, and architecture to limn the true complexity of Asterion’s ties with society. Together, these theories reveal a trove of intricate intrigue and doubt. In this study I examine how Asterion, a reinvention of the Minotaur, is painstakingly …

Latin Mass, Claire Hsu Accomando

Toyon: Multilingual Literary Magazine

"Latin Mass," Atlanta Review, 2016

"Lávese Las Manos," A Year in Ink, 2016

"Christmas Eve at Food 4 Less," The Vagabond Reader, 2013

Exploring The Relationship Between Cellular Senescence, Apolipoprotein E, And Alzheimer’S Disease, Buay Deng

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Alzheimer’s disease (AD) is the most common form of dementia in the world and currently affects more than 50 million people and has no cure to date. One of its major neuropathological hallmarks is the presence of senile plaques—formed from Amyloid-β (Aβ) oligomers. Aβ has also been associated with the development of cellular senescence in preclinical AD models, suggesting that cellular senescence may be mechanistically involved in disease progression. Cellular senescence is a stress response that occurs when cells are exposed to degenerative factors that puts them into permanent cell cycle arrest, this process increases with age. Apolipoprotein E (ApoE) …

Mechanisms Of How Diet And Light Interact To Influence Drosophila Longevity Through The Eye, Charles H. Lau

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Previous studies in Drosophila melanogaster have established that overexposure to light damages photoreceptors and that photoreceptor degeneration contributes to shortened lifespans. However, the role of diet and circadian rhythms in the eye has not yet been elucidated. Many vital processes in the eye are regulated by circadian rhythms, and circadian misalignment has been proven as a driver of aging. In the eye, one of the most enriched circadian functions is phototransduction. Phototransduction plays a major role in the organism’s ability to detect light. Our lab has previously proven that Dietary Restrictions (DR) can play a role in amplifying circadian rhythms …

Influence Of Flipped Learning Strategy On High School Students’ Learning Outcomes In Biology In Osun State, Mutahir Oluwafemi Abanikannda

Frameless

The study was conducted to investigate the influence of flipped learning strategy on high school students’ learning outcomes in Biology in Osun State. The study adopted a descriptive survey and respondents used for the study were three hundred and fifty (350) students were randomly selected from twelve (12) High Schools in Osun State. The study consists of one research question and one research hypothesis. The instrument used to obtain information on this research was an inventory. Frequency counts and percentages with mean deviation was the descriptive statistics used. The research findings revealed that flipped learning strategy has a positive influence …

Suggestions For Grassland Ecosystem Protection And Development In Heilongjiang Province, Y. X. Zhang, G. Q. Han, Duofeng Pan, Z. B. Shen, F. L. Tang

IGC Proceedings (1977-2023)

No abstract provided.

The Livestock And Forage Balance Policy In Practice In China — Evidence From Inner Mongolia Autonomous Region, L. Yang, Saixiyala, Y. L. Ma, M. W. Jiang

IGC Proceedings (1977-2023)

No abstract provided.

Strengthening Pastoral Organization And Indigenous Knowledge For Sustainable Rangeland Management In Nepal, L. Wen, Shikui Dong, K. K. Shrestha, D. Pariya, Zhaoli Yan, Eklabya Sharma

IGC Proceedings (1977-2023)

No abstract provided.

Who's Carrying Capacity?, Wenjun Li, Qian Zhang, Yina Xie, Changling Li, Yanbo Li

IGC Proceedings (1977-2023)

No abstract provided.

Restoration Of Kyrgyz Traditional Knowledge For Sustainable Pasture Management And Use, Asyl Undeland

IGC Proceedings (1977-2023)

No abstract provided.

Exposing Necrocapitalism, Slow Violence, And Precarity: Necropolitics In The Grapes Of Wrath, Dinorah Arista

Theses and Dissertations

This work begins by briefly exploring the historical, environmental, economic, and sociopolitical factors springing up from the Great Depression to the Dust Bowl migration. Although it is argued that John Steinbeck wrote The Grapes of Wrath through a religious lens, Steinbeck alludes to the Bible only as a bridge to a social gospel. More importantly, my focus is mainly centered on Achille Mbembé’s concept of necropolitics (the sovereign right to decide who lives and who dies) and applying it to the first world country of the United States. Mbembé expands on Michel Foucault’s concept of biopolitics by including the state …

Reconstruction Of Femur Length Using The Epiphysial And Diaphysial Diameters In Contemporary Egyptian Sample, With Application To Ancient Egyptians, Mennattallah Hassan Attia, Fatma Mohamed Magdy Badr El-Dine, Nancy Mohamed Aly El-Sekily

Human Biology Open Access Pre-Prints

Inferences in bioarchaeology and forensic contexts require mathematical stature estimation using long bone lengths. This study is in hand to identify predictors of femur length (FL) from epiphyseal and diaphysial width measurements that are not bound to assumptions of sex or laterality. Both standard and new measurements around dominant foramen nutricium (NF) were collected on modern femora (n=64) from Alexandria university unidentified skeletal Collection to compute linear regression models. Four equations were then validated on Ancient Egyptian sample (n=73) from Goldman’s Osteometric dataset to evaluate effect of sex subdivision on the prediction accuracy of FL and indirect stature estimation using …

2021 July 20 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Correction To: Latitudinal Variation In Monthly-Scale Reproductive Synchrony Among Acropora Coral Assemblages In The Indo-Pacific, Jessica Bouwmeester, Alasdair J. Edwards, James R. Guest, Andrew G. Bauman, Michael L. Berumen, Andrew H. Baird

Marine & Environmental Sciences Faculty Articles

No abstract provided.

Focus On Three Major Scientific Issues In Field Of Life And Construct Holographic Human Digital Model—Taking Medicine As Example, Bin Cong, Shiming Zhang, Zhiyu Ni

Bulletin of Chinese Academy of Sciences (Chinese Version)

By analyzing the dilemma faced by the field of medical science, we can find that the nature and evolutionary laws of life have not been systematically revealed; and the microscopic dynamic processes of life cannot be understood by only visualizing the microscopic static structures at the subcellular or molecular levels. Therefore, there is a need to establish a new scientific paradigm to study three fundamental scientific problems in the field of life:to analyze the microstructure of the human body; to reveal the correlations between structures; and to explore the temporal changes of structures and the functions they perform. The human …

Specificity Of Nifen And Vnfen For The Assembly Of Nitrogenase Active Site Cofactors In Azotobacter Vinelandii, Ana Pérez-González, Emilio Jimenez-Vicente, Jakob Gies-Elterlein, Alvaro Salinero-Lanzarote, Zhi-Yong Yang, Oliver Einsle, Lance C. Seefeldt, Dennis R. Dean

Chemistry and Biochemistry Faculty Publications

The nitrogen-fixing microbe Azotobacter vinelandii has the ability to produce three genetically distinct, but mechanistically similar, components that catalyze nitrogen fixation. For two of these components, the Mo-dependent and V-dependent components, their corresponding metal-containing active site cofactors, designated FeMo-cofactor and FeV-cofactor, respectively, are preformed on separate molecular scaffolds designated NifEN and VnfEN, respectively. From prior studies, and the present work, it is now established that neither of these scaffolds can replace the other with respect to their in vivo cofactor assembly functions. Namely, a strain inactivated for NifEN cannot produce active Mo-dependent nitrogenase nor can a strain inactivated for VnfEN …

Oxygen Reactive Polymers For Treatment Of Traumatic Brain Injury, Parick S. Stayton, Menko P. Ypma, Peter A. Chiarelli, Joshua Sang Hun Park, Richard G. Ellenbogen, Julia Mengyun Xu, Pierre D. Mourad, Donghoon Lee, Anthony Convertime, Forrest M. Kievit

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Methods and compositions for treating traumatic brain injury . The methods and compositions utilize a multi - functional oxygen reactive polymer ( ORP ) that includes repeating units that include a reactive oxygen species ( ROS ) scavenging group and a polyalkylene oxide group . For theranostic applications , the oxygen reactive polymer fur ther includes a diagnostic group .

Academic Intensive Care Units: What Is The Impact On Student Achievement?, Brandi Compass

Dissertations

The purpose of this study was to determine if academic intensive care units along with no-zero grading policies at the high school level result in students having higher achievement levels on state EOC assessments. A mixed-methods approach was taken in order to obtain both qualitative and quantitative data from surveys and interviews. Additional quantitative data were analyzed from archival data. Two separate schools were chosen for the populations. High School A implemented academic intensive care units and no-zero grading polices while High School B did not. Participants in the study consisted of both teachers and students at High School A …

A Systematic Review And Meta-Analysis On The Efficacy Of Stem Cell Therapy On Bone Brittleness In Mouse Models Of Osteogenesis Imperfecta, Lauren Battle, Shoshana Yakar, Alessandra Carriero

Publications and Research

There is no cure for osteogenesis imperfecta (OI), and current treatments can only partially correct the bone phenotype. Stem cell therapy holds potential to improve bone quality and quantity in OI. Here, we conduct a systematic review and meta-analysis of published studies to investigate the efficacy of stem cell therapy to rescue bone brittleness in mouse models of OI. Identified studies included bone marrow, mesenchymal stem cells, and human fetal stem cells. Effect size of fracture incidence, maximum load, stiffness, cortical thickness, bone volume fraction, and raw engraftment rates were pooled in a random-effects meta-analysis. Cell type, cell number, injection …

The Anti-Dipsogenic And Anti-Natriorexigenic Effects Of Estradiol, But Not The Anti-Pressor Effect, Are Lost In Aged Female Rats, Jessica Santollo, Jason A. Collett, Andrea A. Edwards

Biology Faculty Publications

Estradiol (E2) inhibits fluid intake in several species, which may help to defend fluid homeostasis by preventing excessive extracellular fluid volume. Although this phenomenon is well established using the rat model, it has only been studied directly in young adults. Because aging influences the neuronal sensitivity to E2 and the fluid intake effects of E2 are mediated in the brain, we tested the hypothesis that aging influences the fluid intake effects of E2 in female rats. To do so, we examined water and NaCl intake in addition to the pressor effect after central angiotensin II treatment in young (3-4 months), …

Structural Atrophy Of The Right Superior Frontal Gyrus In Adolescents With Severe Irritability, Ji-Woo Seok, Sahil Bajaj, Brigette S. Vaughan, Arica Lerdahl, William Garvey, Alexandra Bohn, Ryan Edwards, Christopher J. Kratochvil, James Blair, Soonjo Hwang

Journal Articles: Psychiatry

Severe irritability is common in youths with psychiatric disorders and results in significant dysfunction across domains (academic, social, and familial). Prior structural MRI studies in the pediatric population demonstrated that aberrations of cortical thickness (CT) and gray matter volume (GMV) in the fronto-striatal-temporal regions which have been associated with irritability. However, the directions of the correlations between structural alteration and irritability in the individual indices were not consistent. Thus, we aim to address this by implementing comprehensive assessments of CT, GMV, and local gyrification index (LGI) simultaneously in youths with severe levels of irritability by voxel-based morphometry and surface-based morphometry. …

Methods , Systems , And Devices Relating To Surgical End Effectors, Shane M. Farritor, Thomas Frederick, Joe Bartels

Department of Mechanical and Materials Engineering: Faculty Publications

The embodiments disclosed herein relate to various medical device components , including components that can be incorporated into robotic and / or in vivo medical devices, and more specifically including end effectors that can be incorporated into such devices. Certain end effector embodiments include various vessel cautery devices that have rotational movement as well as cautery and cutting functions while maintaining a relatively compact structure. Other end effector embodiments include various end effector devices that have more than one end effector.