Digital Commons Network^™

Precision Medicine And Triple-Negative Breast Cancer: Current Landscape And Future Directions, Fokhrul Hossain, Samarpan Majumder, Justin David, Lucio Miele

School of Medicine Faculty Publications

Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous subtype of breast cancer associated with a high recurrence and metastasis rate that affects African-American women disproportionately. The recent approval of targeted therapies for small subgroups of TNBC patients by the US ‘Food and Drug Administration’ is a promising development. The advancement of next-generation sequencing, particularly somatic exome panels, has raised hopes for more individualized treatment plans. However, the use of precision medicine for TNBC is a work in progress. This review will discuss the potential benefits and challenges of precision medicine for TNBC. A recent clinical trial designed to target …

A Novel Method For Detecting Wild Boar Presence, Giovanna Massei, Dave P. Cowan, Julia Coats

Human–Wildlife Interactions

Populations of wild boar and feral pigs (Sus scrofa) are increasing in numbers and distribution worldwide, in parallel with their significant environmental and economic impact. Reliable methods to detect the presence of this species are needed for monitoring its natural range expansion and its occurrence in areas where animals have been deliberately or accidentally introduced. The main aim of this study, carried out in English woodlands recently colonized by wild boar, was to assess the effectiveness of a birch wood tar-based compound, to detect the presence of this species in presence/absence surveys. A pilot trial in woodlands where …

Integrating Literature, Biodiversity Databases, And Citizen-Science To Reconstruct The Checklist Of Chondrichthyans In Cyprus (Eastern Mediterranean Sea), Ioannis Giovos, Fabrizio Serena, Dimitra Katsada, Athanasios Anastasiadis, Adi Barash, Charis Charilaou, Jason M. Hall-Spencer, Fabio Crocetta, Alexander Kaminas, Demetris Kletou, Mary Maximiadi, Vasileios Minasidis, Dimitrios K. Moutopoulos, Aga-Spyridopoulou R Naasan, Ioannis Thasitis, Periklis Kleitou

School of Biological and Marine Sciences

Chondrichthyans are apex predators influencing the trophic web through a top-down process thus their depletion will affect the remaining biota. Notwithstanding that, research on chondrichthyans is sparse or data-limited in several biogeographic areas worldwide, including the Levantine Sea. We revise and update the knowledge of chondrichthyans in Cyprus based on a bibliographic review that gains information retrieved from peer-reviewed and grey literature, Global Biodiversity Information Facility (135 records of at least 18 species) and the Ocean Biodiversity Information System (65 records of at least14 species), and the citizen science project Mediterranean Elasmobranchs Citizen Observations (117 records per 23 species). Our …

Hardware Acceleration In Image Stitching: Gpu Vs Fpga, Joshua David Edgcombe

Masters Theses

Image stitching is a process where two or more images with an overlapping field of view are combined. This process is commonly used to increase the field of view or image quality of a system. While this process is not particularly difficult for modern personal computers, hardware acceleration is often required to achieve real-time performance in low-power image stitching solutions. In this thesis, two separate hardware accelerated image stitching solutions are developed and compared. One solution is accelerated using a Xilinx Zynq UltraScale+ ZU3EG FPGA and the other solution is accelerated using an Nvidia RTX 2070 Super GPU. The image …

Data-Driven Discovery Of The Governing Equation For The Transmission Lines System, Yanming Zhang, Lijun Jiang

Electrical and Computer Engineering Faculty Research & Creative Works

Sophisticated structures in the transmission line system introduce the nonuniformity and nonlinearity, which brings the challenge for its characterization and modeling. In this work, a novel data-driven method is proposed to derive the governing partial differential equations of the transmission line. Based on the polynomial interpolation of the spatial-temporal samples of current and voltage, the time and spatial derivatives can be obtained. Then, the ridge regression algorithm is adopted to determine the active spatial differential terms from the candidate functions. Three benchmarks, the uniform and nonuniform transmission line, and a soliton generation system, are provided to demonstrate the validity of …

Intensive Hunting Pressure Changes Local Distribution Of Wild Boar, Jakub Drimaj, Jiří Kamler, Radim Plhal, Přemysl Janata, Zdeněk Adamec, Miloslav Homolka

Human–Wildlife Interactions

Wild boar (Sus scrofa) is now an important species of wild ungulates in Central Europe. Next to conflicts of wild boar with agriculture, the main threat of wild boar presence lies in the expansion of African swine fever across Europe. The regulation of the wild boar population is complicated by the high reproduction rate and intelligent behavior of the species, which limits hunting effectiveness. We analyzed the spatial behavior of wild boar in an environment with a lack of natural food resources. The study area consisted of a forest complex (1,283 ha) with 2 areas. In the “risk” …

Dimeric Allostery Mechanism Of The Plant Circadian Clock Photoreceptor Zeitlupe, Francesco Trozzi, Feng Wang, Gennady M. Verkhivker, Brian D. Zoltowski, Peng Tao

Mathematics, Physics, and Computer Science Faculty Articles and Research

In Arabidopsis thaliana, the Light-Oxygen-Voltage (LOV) domain containing protein ZEITLUPE (ZTL) integrates light quality, intensity, and duration into regulation of the circadian clock. Recent structural and biochemical studies of ZTL indicate that the protein diverges from other members of the LOV superfamily in its allosteric mechanism, and that the divergent allosteric mechanism hinges upon conservation of two signaling residues G46 and V48 that alter dynamic motions of a Gln residue implicated in signal transduction in all LOV proteins. Here, we delineate the allosteric mechanism of ZTL via an integrated computational approach that employs atomistic simulations of wild type and …

That T-Rex Is Mine! A Note On The Montana Supreme Court Decision Murray V. Bej Minerals, Llc, Bryce Hayden

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Review Of: Understanding And Dismantling Racism: Crowdsourcing A Pathway Model In Appalachia, Matthew F. Hudson

Journal of Appalachian Health

The Journal of Appalachian Health is committed to reviewing published media that relates to contemporary concepts affecting the health of Appalachia. Examining Institutional Racism’s impact on health, career advancement and outcomes in Appalachian communities, impacts our ability to address and identify solutions to inform the fundamental framing of health equity. Dr. Matthew F. Hudson critiques the website: Understanding and Dismantling Racism: Crowdsourcing a Pathway Model in Appalachia.

Triple Negative Breast Cancer In An Appalachian Region: Exponential Tumor Grade Increase With Age Of Diagnosis, Gina Sizemore, Toni Marie Rudisill

Journal of Appalachian Health

Introduction: Triple negative breast cancer is an aggressive breast cancer with decreased five-year survival, increased risk for recurrence, and higher risk for metastases. Unlike other breast cancers, it has no targeted treatment and has heterogeneous genetics which make classification and treatment difficult.

Purpose: The purpose of our research was to compare triple negative breast cancer to non-triple negative breast cancer to identify key epidemiologic factors that might lead to improved basic science directives for biomarkers, treatments, and classification.

Methods: The state cancer registry was used to provide the first West Virginia state-wide population evaluation of triple negative breast cancer.

Results: …

Establishing Peer Recovery Support Services To Address The Central Appalachian Opioid Epidemic: The West Virginia Peers Enhancing Education, Recovery, And Survival (Wv Peers) Pilot Program, Stephen M. Davis, Amanda Stover, Herb Linn, Jon Dower, Dan Mccawley, Erin Winstanley, Judith Feinberg

Journal of Appalachian Health

Introduction: Central Appalachia has been disproportionately affected by the opioid epidemic and overdose fatalities. We developed West Virginia Peers Enhancing Education, Recovery, and Survival (WV PEERS), a program based on peer recovery support, to engage individuals using opioids and link them with a range of services.

Methods: Community partners providing services to individuals with opioid use disorder (OUD) were identified and collaborations were formalized using a standardized memorandum of understanding. The program was structured to offer ongoing peer recovery support specialist (PRSS) services, not just a one-time referral. A website and cards describing the WV PEERS program were developed and …

Appalachia: Putting The "Critical" In Race And Crowdsourcing A Pathway Model On Institutional Racism, Lauri Andress, Keri Valentine

Journal of Appalachian Health

As the website Understanding and Dismantling Racism: Crowdsourcing a Pathway Model in Appalachia explains, we are seeking assistance in refining a pathway model that elucidates institutional racism from the unique standpoint of Appalachia. We think that Appalachia has a distinctive cultural toolkit that shapes its orientation on issues. Our goal is to use crowdsourcing to harness this unique Appalachian ethos to refine the Pathway model on Institutional Racism based on comments, edits, questions, and ideas left on the website.

Hysteresis Phenomena Of Biological System., R. El-Awady

Mansoura Engineering Journal

In this work we tried to find the effect of cyclic stress on the behaviour of biological systems. The effect was repeated many time and the reponse of the biological system was measured. The stress was chosen to be the step changes in environmental pressure and the response was the respiratory rate. The experiment was repeated ten times.

From Exposure To Violence Between Mother And Her Intimate Partner To Suicidality Experienced By Urban Adolescents In Chicago’S Southside, Dexter R. Voisin

Faculty Scholarship

Although the relationship between exposure to intimate partner violence and youths’ psychological and other wellbeing has been widely studied, there is limited research about how youths’ exposure to violence between mother and her intimate partner may be related to youth psychological wellbeing. The study used a sample of urban adolescents in Chicago Southbound to examine whether youths’ exposure to verbal conflict between mother and her intimate partner is related to their suicidality and whether youth depression and aggression may be in between such a linkage. Our findings indicated that one-third of the youth had suicidal thoughts or suicidal/self-hurting attempts. Youths’ …

John The Revelator: A Spatial Interpretation, Jon Warland

Consensus

No abstract provided.

Periodontal Microbiome Part I: A Literature Review, Carole Chakar, Gabriel Menassa, Roudy Khayat

International Arab Journal of Dentistry

Periodontal disease is one of the most chronic infectious diseases, it is initiated by a reversible inflammatory condition called gingivitis, if untreated, it progresses to an irreversible condition called periodontitis, if not resolved, it leads to tooth loss. Periodontitis is a multifactorial disease, one of these factors is the periodontal microbiome. Consequently, the microbiome is altered according to the host state i.e., health, gingivitis, periodontitis. The microbiome in health is comprised of a variety of microorganisms called health-associated species. They consist of gram-positive cocci and rod with gram-negative species. In this state, the microbiome participates in various physiological functions. While …

Facial Diplegia: A Rare, Atypical Variant Of Guillain-Barré Syndrome And Ad26.Cov2.S Vaccine, Esha Jain, Krunal Pandav, Pratima Regmi, George Michel, Ida Altshuler

Publications and Research

This potentially life-threatening disease poses an interesting perspective on adverse events that can occur or can be exacerbated following the Ad26.COV2.S (Johnson & Johnson) vaccine. The authors report findings in a 65-year-old female patient who experienced facial diplegia, an atypical variant of Guillain-Barré syndrome, two weeks after receiving the Ad26.COV2.S vaccine against coronavirus disease 2019. Post-approval pharmacovigilance of each vaccine helps better understand the long-term outcomes, and reporting adverse events is crucial for advancements in medical knowledge.

Relationship Between Edentulism And Sleep Apnea: A Systematic Review Of The Literature, Sinda Ammar, Yosra Mabrouk, Amel Labidi, Lamia Mansour, Mounir Trabelsi

International Arab Journal of Dentistry

Edentulism could be the cause of impaired respiratory function, especially during sleep. The aim of this systematic review of the literature was to study the relationship between edentulism and sleep apnea. The search was performed on MEDLINE (PubMed), with different Boolean equations. A manual search was also carried out. 19 articles were selected. 17 have shown that edentulism promotes the onset of obstructive sleep apnea. In 6 studies, an improvement in sleep apnea was noted with wearing the prosthesis at night, unlike the other 4 studies reported a deterioration in sleep quality with wearing the prosthesis. A strong relation was …

Natural History And The "Scientific Discourse Community" Of The Three Zhou Brothers, Jianrong Liao

Theoretical Studies in Literature and Art

As the mainstream of modern science, natural history has developed from Foucauldian epistemological discourse to the important discourse of "scientific discourse community," which has become the basis of legitimacy for a new culture and new thought that promoted the New Culture Movement. As the scientific discourse of the three Zhou brothers, natural history influenced Lu Xun's (Zhou Shuren) "saving the nation through science" and "biological truth", Zhou Zuoren's "biological reference" and "naturalization of ethics", as well as Zhou Jianren's "national evolution" and related ideas of new culture. Zhou Brothers' scientific discourse of natural history witnessed the unremitting exploration of Chinese …

Non-Archimedean Models Of Morphogenesis, Wilson A. Zuniga-Galindo

School of Mathematical & Statistical Sciences Faculty Publications

We study a p-adic reaction-diffusion system and the associated Turing patterns. We establish an instability criteria and show that the Turing patterns are not classical patterns consisting of alternating domains. Instead of this, a Turing pattern consists of several domains (clusters), each of them supporting a different pattern but with the same parameter values. This type of patterns are typically produced by reaction-diffusion equations on large networks.

Cytokeratin Overexpression In Submandibular Salivary Glands Of Rats Treated With Botulinum Toxin And Epidermal Growth Factor, Mahmoud Bakr, Mahmoud Al Ankily, Mohamed Shamel

Dentistry

Botulinum toxin (BTX) is used in different cosmetic and therapeutic procedures. In dentistry, BTX has been used successfully for management of drooling. BTX injection into salivary glands has damaging adverse effects on all components of the gland. Epidermal Growth Factor (EGF) is well known for its regenerative properties. The aim of this study was to investigate the effect of BTX injections on the submandibular salivary glands of adult female Albino rats, when administered solely or in conjunction with EGF through measuring the expression of cytokeratin in the parenchyma of the gland. Sixty rats were used in this study and were …

Blood-Based Biomarkers For Amyotrophic Lateral Sclerosis, Heather M. Wilkins, Mazen M. Dimachkie, Abdulbaki Agbas

Faculty and Staff Publications

Early detection of amyotrophic lateral sclerosis (ALS) is critical for better therapeutic outcomes. The median time from symptom onset to diagnosis of ALS is 11 months, with a range of 6-21 months. Given that the median life expectancy is three years, it is important to shorten the diagnostic journey, initiate therapies promptly, and facilitate clinical research participation. Biomarkers may be the key to enhancing early diagnosis, tracking disease progression, and testing target engagement of promising therapeutics. Clinically valid biomarkers for ALS are currently lacking, and research has been ongoing to identify appropriate biomarkers. Ideal biomarkers should be minimally invasive, such …

The Conservation Of Grasslands And Rangeland By Pastoralists: Challenges And Opportunities, Thomas M. Loquang

IGC Proceedings (1977-2023)

No abstract provided.

Diversity Of Grassland Resources And Modernization Of Pastoral Areas — The Comparative Study Of Grass Industry Among Usa, Mongolia And China, Jin Yi, Puchang Wang

IGC Proceedings (1977-2023)

No abstract provided.

Genetic Diversity Evaluation Of Roegneria Kamoji Ohwi Germplasm From Different Ecoregions In China, Zhu Xu, H. J. Xiao, David L. Michalk

IGC Proceedings (1977-2023)

No abstract provided.

Issr Analysis On Genetic Diversity Of Wild Agrostis Stolonifera L. Germplasm Resources, Xiaoli Wang, Chengbin Tang, Li Zhong, Wei Chen, Jiahai Wu, Qun Mu, Xiaoxia Liu

IGC Proceedings (1977-2023)

No abstract provided.

Population Genetic Diversity Of Potaninia Mongolica Maxim, Hong Jin, Yongming Zhang, Lan Yun

IGC Proceedings (1977-2023)

No abstract provided.

Are Rangeland Management Policies Inappropriate To Biodiversity Conservation On The Western Tibetan Plateau, Tibet Autonomous Region, China?, J. L. Fox, Tsechoe Dorji, K. Dondhup

IGC Proceedings (1977-2023)

No abstract provided.

Combined Physical Training Increases Plasma Brain-Derived Neurotropic Factor Levels, But Not Irisin In People Living With Hiv/Aids, Joice Cristina Dos Santos Trombeta, Roberto Carlos Vieira Junior, Cláudia Regina Cavaglieri, Ivan Luiz Padilha Bonfante, Jonato Prestes, Ramirez Alsamir Tibana, Morteza Ghayomzadeh, Vinicius Carolino Souza, Seyedahmad Seyedalinaghi, James Wilfred Navalta, Fabrício Azevedo Voltarelli

International Journal of Exercise Science

International Journal of Exercise Science 14(3): 1004-1017, 2021. This study evaluated plasma levels of brain-derived neurotropic factor (BDNF), irisin, and lactate in people living with HIV/AIDS who completed a combined physical training program. Nineteen HIV⁺ participants (age: 39.60 ± 10.96 years; carrier time: 7.75 ± 7.88 years; time of ART: 6.41 ± 5.93 years) performed strength/aerobic training (combined physical training) in the same session for 8 weeks and levels of BDNF, irisin, and lactate were assessed. BDNF (pg/mL) was higher post-CPT (Pre: 1258.73 ± 372.30; Post: 1504.17 ± 322.30; p < 0.001). Irisin (ng/mL) showed no change (Pre: 115.61 ± 72.41; Post: 125.87 ± 81.14; p = 0.973). There was positive correlation between irisin …

Motif Wfyy Of Human Primpol Is Crucial To Stabilize The Incoming 3′-Nucleotide During Replication Fork Restart, Patricia R. Calvo, María I. Martínez-Jiménez, Marcos Díaz, Gorazd Stojkovic, Kazutoshi Kasho, Susana Guerra, Sjoerd Wanrooij, Juan Méndez, Luis Blanco

Chemistry and Physics Faculty Articles

PrimPol is the second primase in human cells, the first with the ability to start DNA chains with dNTPs. PrimPol contributes to DNA damage tolerance by restarting DNA synthesis beyond stalling lesions, acting as a TLS primase. Multiple alignment of eukaryotic PrimPols allowed us to identify a highly conserved motif, WxxY near the invariant motif A, which contains two active site metal ligands in all members of the archeo-eukaryotic primase (AEP) superfamily. In vivo and in vitro analysis of single variants of the WFYY motif of human PrimPol demonstrated that the invariant Trp⁸⁷ and Tyr⁹⁰ residues are essential …