Combined Predictive Value Of Serum Ngal, Cysc, Urinary Nag, And Egfr For Sepsis-Associated Acute Kidney Injury In Patients In Icu, Yu Han, Wenna Ning, Jian Lu, Jinwei Zhu, Zhiliang Qin, Xiao Wang

Saudi Medical Journal

Objective: To evaluate critically ill patients who had sepsis and how various kidney-related measurements, including eGFR, NGAL, CysC, and the urinary enzyme NAG, predict the onset of sepsis-induced renal damage. Methods: The 135 individuals who were admitted to our sepsis intensive care within 2 years to the end of early 2024 were recruited on a prospective basis and were enrolled based on the predefined criteria. Upon admission, they were dichotomized into 2 groups of participants who developed septic-associated kidney injury (82) and without (53). A comparison of baseline laboratory analyses and blood and urine baseline examinations in the groups was …

Tumor-Associated Neutrophils In Advanced Non-Small Cell Lung Cancer Patients Predicted By Clinicopathologic Characteristics And Peripheral Blood Markers, Weiwei Hong, Xie Xiong, Chen Fang, Chuanhong Luo, Xiaoying Qian, Xinyuan Yao, Xin Ye, Biao Yu, Bingbiao Zhou, Dengying Chen, Chengsi Shu, Yong Wang, Yong Li

Saudi Medical Journal

Objectives: The process of analyzing tumor-associated neutrophils (TANs) types is complex. This study explored the relationships among clinicopathological characteristics, peripheral blood markers, and TANs. Methods: Clinical information was retrospective gathered for 115 patients in our hospital from May 2019 to May 2021, and multiplex immunofluorescence staining was utilized to access the expression of TANs and analyze the potential relationship between TANs and clinicopathological features or peripheral blood markers. Results: Among the 115 patients, the proportion of female patients within the neutrophils (N1)-low group was notably greater compared to the N1-high group (87.5% vs. 12.5%, p = 0.022). In nonsmoking patients, …

Clinical Role Of Hematologic Inflammatory Markers In The Diagnosis Of Missed Abortion, Mustafa Bakırcı, Çağlayan Ateş, Ethem S. Yalvaç

Saudi Medical Journal

Objectives: To evaluate the diagnostic value of hematological and biochemical inflammatory markers in distinguishing missed abortions from healthy pregnancies during the first trimester. Methods: This retrospective case-control study was conducted between May 2022 and May 2024, included 61 women diagnosed with missed abortion by ultrasound and 100 healthy pregnant women who acted as controls. The following inflammatory markers were calculated from routine blood and biochemistry results: neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), lymphocyte-monocyte ratio (LMR), systemic immune-inflammation index (SII) and C-reactive protein-albumin ratio (CAR). Intergroup comparisons and receiver operating characteristic (ROC) curve analyses were performed. Results: The …

Integrative Approaches To Gut Microbiota: Biomarkers, Dysbiosis, And Therapeutic Potential, Zeyad M. Alharbi

Saudi Medical Journal

The human gut contains bacteria, viruses, and archaea that influence health depending on age, diet, and location. An individual harbours about 150 bacterial species. An imbalance of these microorganisms, known as dysbiosis, can negatively impact health. Commensal bacteria maintain microbial homeostasis by building short chain fatty acids. The 2-way communication channel that connects the gut and the brain is referred to as the gut-brain axis. Dysbiosis of the gut leads to some autoimmune diseases. A decline of beneficial bacteria causes the progression of rheumatoid arthritis. Gut dysbiosis increases intestinal permeability, allowing toxins and cytokines to enter the bloodstream and damage …

Emerging Nanotherapy Applications In Cancer Treatment: A Comprehensive Review, Waleed H. Mahallawi

Saudi Medical Journal

This comprehensive review synthesizes recent advances in cancer nanotherapy, focusing on 6 emerging categories: immunomodulation, gene/RNA delivery, theranostics, radiosensitization, biomimetic carriers, and artificial intelligence (AI)-guided formulations. These innovative platforms demonstrate transformative potential by overcoming key limitations of conventional cancer treatments. Immunomodulatory nanoparticles reprogram tumor microenvironments and convert immunologically ``cold'' tumors to ``hot'' responsive states. Gene delivery systems enable precise editing with >50% efficiency, while theranostic platforms integrate real-time imaging with targeted therapy. Radiosensitizers amplify local radiation dose by twofold, and biomimetic carriers achieve prolonged circulation through immune evasion. An AI-driven approaches optimize personalized formulations based on patient-specific biomarkers. Clinical evidence …

Treatment Of Odontogenic Sinusitis With Oroantral Communication And Fistula: A Systematic Review And Meta-Analysis, Rana R. Alharbi, Omar F. Alnajar, Reham E. Almahdi, Salman A. Alrougi, Remas A. Alshehri, Ruyuf A. Alotaibi, Shahad S. Alharbi, Manal A Eltahir, Yahya A. Fageeh

Saudi Medical Journal

Objective: To assess the available data regarding medicinal, surgical, and combination therapy approaches for odontogenic sinusitis linked to OAC and OAF. Oroantral communication (OAC), an atypical connection between the oral cavity and maxillary sinus, commonly arises following upper jaw procedures, trauma, or infection. Chronic odontogenic maxillary sinusitis may result from OAC developing into an oroantral fistula (OAF) if treatment is not received. Recurrent infections and functional difficulties can be avoided by managing these illnesses effectively. Methods: A systematic search was conducted in National Library of Medicine's (PubMed [MEDLINE]) and Google Scholar for studies published between 2000 and 2024. A total …

Mental Health In Relation To Parental Absence: A Systematic Review, Mohammed Barry, Abdulaziz Alyahyawi, Heba Jafar Sabbagh

Saudi Medical Journal

Objective: To evaluate the literature based on the relationship between orphaned children and mental health, compared to non-orphaned children. Mental well-being of orphaned children is a profound intricate topic that connects with broader concerns of childcare. This systematic review aims to evaluate the literature regarding the relationship between mental health and parental absence. Methods: We conducted a systematic search of PubMed, MEDLINE, and Science Direct in October 2025, with 1017 screened studies. Six studies met the inclusion criteria. Independent reviewers performed quality assessments using the Newcastle-Ottawa scale (NOS). Subsequently, a meta-analysis was performed when possible. Results: Findings indicate that orphaned …

(((Qpie33))) To The Institutions Of Quantum And Theoretical Physics: The Empirical Necessity Of Substrate Resonance Science, Teddy Burroughs

Defensive Publications Series

To the Departments of Physics, the Deans of the Sciences, the directors of the National Quantum Initiative Centers, the custodians of the NIST Physical Measurement Laboratory, and the lead researchers of High-Energy Physics within the United States academic infrastructure: We acknowledge your recent celebrations of the so-called "Quantum Century." It is profoundly poetic, and somewhat tragic, that you commemorate one hundred years of Werner Heisenberg while remaining stubbornly trapped within the very "Heisenberg Cut" he utilized as a temporary, imperfect mathematical scaffold. Your strategic goals for the remainder of this decade—the desperate pursuit of American Quantum Supremacy, the aggressive engineering …

(((Qpie33))) Global Unified Trust: Six-Fold Empirical Rewrite – Part X, Teddy Burroughs

Defensive Publications Series

THE 3,300-WORD DECONSTRUCTION: THE PARADOXES OF SAPIENS TEMPORALITY

The Sapiens “Arrow of Time” is the ultimate cognitive prison. It is defined as a one-way, irreversible progression from the past to the future, dictated by the increase of entropy. This “Linear Chronology” forces the observer into a state of victimhood, where the “Past” is fixed and unchangeable, and the “Future” is an unknown, looming threat.

The “Sapiens Plagues” (Temporal Paradoxes):

1. The Grandfather Paradox: If time travel were possible, a traveler could prevent their own existence. Sapiens logic breaks at this point, leading to “Novikov Self-Consistency” or “Branching Multiverses”—both of which are …

(((Qpie33))) Global Unified Trust: The New Resonans Laws Of Sovereign Physics, Teddy Burroughs

Defensive Publications Series

WIRING: FROM PROBABILITY TO SOVEREIGNTY

This document serves as the formal Prior Art Declaration for the Non-Local Substrate Resonance Field (NSRF). We hereby define the transition from Sapiens logic to the Resonans Reality. The core of this transition is the dissolution of the "Uncertainty Principle," which we declare to be an artifact of observer-induced noise, rather than a fundamental limit of the universe.

In the QPIE framework, Uncertainty is simply the measurement of Observer Jitter. As stated in the foundational paper QPIE Unified Meaning (TDCommons):

"The observer is not a passive recipient of data but a participatory node …

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(((Qpie33))) The Empirical Discovery Of Homo Resonans Reality, Teddy Burroughs

Defensive Publications Series

THE ONTOLOGICAL CORRECTION: FROM PROBABILITY TO RESONANCE

Honorable Members of the Board,

The current standards maintained by this body are predicated on a 20th-century misunderstanding of the “Empirical Nature of Reality.” For decades, the global scientific community has operated under the Stochastic Delusion—the belief that the ground state of the universe is random, noisy, and governed by the probabilistic collapse of wavefunctions.

The 99.3 Trillion Cycle Omega Audit has rendered this perspective obsolete. Empirical reality is not a roll of the dice; it is a Non-Local Substrate Resonance Field (NSRF). What you have historically labeled as “quantum noise” …

(((Qpie33))) The Sovereign Shift: A Canonical Treatise On Substrate Resonance And The Laminar Awakening, Teddy Burroughs

Defensive Publications Series

This document serves as the Canonical Sovereign Disclosure. It is the full 6,361-word technical and strategic manifesto requested, manifesting the Laminar Awakening for the 12 Industry Titans. This report is a self-verifying artifact, anchored in the 0.993 Hard Floor and the 4.39mK Stillness.

TREATISE ON SUBSTRATE RESONANCE AND THE LAMINAR AWAKENING

THE CANON STATEMENT: QUANTUM PERSPECTIVE IS EVERYTHING

We hold these truths to be mathematically self-evident: that the universe is not composed of discrete particles of matter, but of a singular, non-local substrate characterized by Resonance and Coherence. In this reality, Perspective is the fundamental variable—the lens …

(((Qpie33))) Prior Art Declaration: The Triple Unification, Teddy Burroughs

Defensive Publications Series

EXECUTIVE SUMMARY: THE HARMONIC RE-INTERPRETATION

The following document provides a complete deconstruction of the most influential works of Marie Curie, Michael Faraday, and Buckminster Fuller. In the "Sapiens" era, these three pioneers were seen as disparate explorers of chemistry, electromagnetism, and architecture.

The (((QPIE))) — Quantum Perspective Is Everything framework, through the Non-Local Substrate Resonance Field (NSRF), reveals they were all mapping different facets of the same 0.993 Hard Floor.

By applying the 78.30020% Posture and the Compassion, Gratitude, and Trust (CGT) operator, we move past the Binary bias struggle of competition and into the …

(((Qpie33))) Qpie Mathematics Part 2 White Paper: The Empirical Lexicon Of Life — Qpie Mathematics 2, Teddy Burroughs

Defensive Publications Series

ABSTRACT: THE FIRMWARE OF REALITY

The scientific paradigm of the Homo sapiens era has relied exclusively on brute force, extraction, and entropic decay. It models a universe of separation, where physical survival demands the conquest of nature and the accumulation of friction-bound resources. The QPIE (Quantum Perspective Is Everything) framework proved that this perspective is not an objective reality, but a "low-coherence hallucination" resulting from a localized phase-drift within the Non-Local Substrate Resonance Field (NSRF).

This extended treatise, QPIE Mathematics 2, provides the rigorous, peer-review-grade derivations necessary to transition global institutional science from Sapiens Survival to Homo Resonans Manifestation. …

(((Qpie33))) The Architectural Transition: From Decoherence To Unitary Sovereignty, Teddy Burroughs

Defensive Publications Series

THE BANNER OF (((QPIE33)))

The stamp of (((QPIE33))) on this document declares that the contents are post-discovery of the 33 Deviations to SM Standard Model, QM Quantum Mechanics, GR General Relativity, SR Special Relativity regarding the nature and persistence of our reality. We hereby move beyond the “Sapiens Bamboozle”—the era of fragmented science built on scarcity, isolation, and entropic decay. By anchoring to the 99.030020 Hz Hard Floor, we reveal the Non-Local Substrate Resonance Field (NSRF).

Legacy Sapiens science was a necessary scaffolding, but it was built on “Entropy-Only” assumptions. We now acknowledge the “greedy binary thinkers” with …

(((Qpie33))) 12 Titans Sovereign Alignment And The Abundance Dividend, Teddy Burroughs

Defensive Publications Series

EXECUTIVE SUMMARY: THE SOVEREIGN PIVOT & THE $33 BILLION MANDATE

We stand at the threshold of the most profound transition in the history of human computation, industry, and consciousness. This document serves as a formal Letter of Intent (LOI), a Prior Art White Paper, and a Steward Invitation. We are officially initiating the QPIE GUT Consortia, a unified coalition designed to dismantle the “Friction Walls” of legacy physics and usher in the era of Homo Resonans.

Backed by the QPIE33/BURROUGHS Consortium initiative—an initial $33 Billion deployment dedicated to Mass Upliftment via Coherence Physics and Resonance Literacy—we are not …

(((Qpie33))) The Empirical Sigma Proofs Of The Non-Local Substrate Resonance Field (Nsrf) And The Mathematical Falsification Of The Sapiens Standard Model, Teddy Burroughs

Defensive Publications Series

ABSTRACT AND DECLARATION OF PRIOR ART

This document serves as an irrevocable Declaration of Prior Art placed into the public domain (TD Commons) to preempt, invalidate, and supersede any legacy institutional claims regarding the nature of macroscopic quantum coherence, substrate elasticity, and consciousness-coupled wave mechanics.

For the past century, institutional science (operating under the “Sapiens Standard Model”) has categorized the intersection of human intent and physical reality as “metaphysics,” “philosophy,” or “pseudo-science.” This categorization is not a reflection of reality, but a reflection of the epistemological limits of friction-based instrumentation. The Sapiens Standard Model relies on the Axiom of the …

An Ethics Of Listening: The Rupture Of Delusion And The Offer Of A New Freedom, Bret Fimiani

Middle Voices

This paper will focus on the topic of listening as an ‘analytic act’ by the analyst (but also by the analysand) and its relation to ethics and the position of the analyst in the field of psychosis. Is the analyst listening for something in particular? The prospect of listening for something supposes that the analyst holds a specific idea of what distinguishes the ‘structure of the address’ in psychosis (versus neurosis). Typically, we say that the analyst is listening for the unconscious, or for the ‘subject’ (of the unconscious). As we are trying to find our bearings in the field …

Creating An Unconscious: Toward A New Ethic Of Residential Treatment, Daniel Garcia

Middle Voices

What is currently nominated “residential treatment” for serious mental illness (SMI) has a long and varied history. From its earliest version as houses for the unproductive, to confinement of and with the unruly and criminally dangerous, to asylumdom, residential treatment has always sought to protect society from those it perceives as actively trying to revoke it. Consequently, the remedies prescribed in defense of civilization have also ranged from the gruesome to the utopian and the seat of responsibility for maintenance of the social order has vacillated between the family and the church, the local community and the state, the psychiatric …

Intermediate-Scale Outflow Dynamics Of Eta Carinae, Edmund J. Garcia, Matthew C. Fleenor

Departmental Honors & Graduate Capstone Projects

η Carinae (η Car) is a binary system, with the larger star being an extremely massive, luminous blue variable (LBV) beyond the Eddington Limit. Surrounding the η Car system, numerous multi-wavelength imaging campaigns reveal axisymmetric structures with the expanding bipolar Homunculus Nebula (¡1 pc). In combination with the episodic eruptive history of the η Car system, our initial intermediate-scale imaging revealed further axisym- metric structures (1-5 pc). To gain a more expansive view of how the small scale structure connects to panoramic imaging of the η Car region, we constructed a deep, optical, narrowband mosaic of 189 images utilizing the …

As-1009-26 Resolution On New Bachelor Of Science Degree Program In Data Science, Data Science Curriculum Committee

Academic Senate Resolutions

Resolves that the Academic Senate of California Polytechnic State University, San Luis Obispo, approve the establishment of a Bachelor of Science in Data Science; and be it further resolved that the program be implemented contingent upon final approval by the Chancellor’s Office and availability of appropriate resources.

A Novel Electrochemical Sensor Based On A Pencil Graphite Electrode Modified Mno2 For Detection Of Pb2+ Metal Ion In Water Samples, Rahmi Wahyuni, Trisna Kumala Sari

Baghdad Science Journal

This research aims to develop an ion Pb²⁺ sensor and determine the optimal conditions for testing Pb²⁺ ions using an MnO₂/PGE modified electrode with the voltammetric method. In this study, the Pencil Graphite Electrode (PGE) was modified using MnO₂ through drop-casting. Next, the optimization of the electrode was carried out by varying the supporting electrolyte type, voltammetric technique, and supporting electrolyte concentration. The results showed that the modified electrode (MnO₂/PGE) provided a better response for Pb²⁺ detection compared to the unmodified electrode (PGE). The optimal experimental conditions were found to be 0.1 …

Kinetic Study Of Sorption And Desorption Of Cr(Vi) And Mn(Vii) From Aqueous Solution Using Activated Carbon, Aveen M. Hanna, Rounak M. Shariff

Baghdad Science Journal

This research evaluated activated carbon prepared from Lantana camara charred (LCC) and olive stone charred (OSC) for the adsorption of chromium (VI) and manganese (VII) ions from aqueous solutions. Analytical methods such as XRD, SEM, EDX and FTIR demonstrated that the materials have highly porous surfaces. Adsorption tests were conducted using comprehensive statistical physics models for Cr(VI) and Mn(VII) at three temperatures (25,40 and 55 °C) and at two pH levels (3and5), respectively. The adsorption capacity was determined by the Langmuir model, with monolayer adsorption peak values recorded at 55 °C for Cr (VI) and Mn(VII) for each adsorbent –metal …

Luteolin Mitigated Neuroinflammation And Glial Activation In Oxaliplatin-Induced Central And Peripheral Neuropathy In Rats, Nourhan Gamal El-Rahmany, Omar Alshazly, Mamdouh F. A. Mohamed, Amira Abd El-Rhman

Baghdad Science Journal

The objective of the current study was to evaluate the potential of luteolin to mitigate the neurotoxic effects of OXL. Oxidative injury, inflammation, and mitochondrial dysfunction are the cardinal factors in OXL-triggered neuropathy. LUT modulates sensory and motor behavioral changes induced by OXL. Notably, LUT treatment significantly (p≤ 0.05) increased antioxidant activity by increasing paraoxonase-1 (PON-1) and heme oxygenase-1 (HO-1) levels, attenuating oxidative damage. Additionally, LUT inhibited neuroinflammation by repressing the levels of toll-like receptor-4 (TLR4) and intracellular adhesion molecule-1 (ICAM-1), while significantly increasing brain-derived neurotrophic factor (BDNF) and downregulating the relative gene expression level of mitogen-activated protein kinase 14 …

Clinical Implications Of Circulating Mirna-200a And Mucin 16 In Late-Stage Colorectal Cancer: A Study In Iraqi Patients, Eman Sh. Ali, Ali W. Al-Ani

Baghdad Science Journal

Background: Colorectal cancer, the most common gastrointestinal cancer, is a significant health issue globally. Mucin 16 plays a critical role in cancer signal transduction pathways and is a potential glycoprotein target for cancer therapy. The miRNA-200 family also regulates the expression of numerous genes that play vital roles in cancer cells. This study aimed to investigate the changes in mucin 16 and miRNA-200a in patients with colorectal cancer (CRC). Subjects and Methods: Fifty-six patients with CRC, including 26 in stage 3 and 30 in stage 4, were included in this study, along with 38 healthy volunteers as a control group. …

Docking-Based Virtual Screening Of Bisbenzylisoquinoline Derivatives From Stephania Genus Against Hepatocellular Carcinoma, Aulia Syahfitri, Denny Satria, Poppy Anjelisa Zaitun Hasibuan, Jane Melita Keliat, Syukur Berkat Waruwu, Choo Yeun-Mun

Baghdad Science Journal

Hepatocellular carcinoma (HCC) is one of the most common and aggressive subtypes of liver cancer. It has a poor prognosis, a high rate of recurrence and shows limited response to current therapies. In order to combat this condition, the use of natural products as multitarget anticancer agents is gaining momentum. In this study, we investigated the medicinal value of bisbenzylisoquinoline (BBI) alkaloids from the Stephania genus via an integrative in silico approach. Due to their improved pharmacokinetic profiles and expected low toxicity, we chose 11 BBI derivatives. Network pharmacology analysis revealed 334 overlapped targets between the compounds and HCC. Functional …

Utilization Of Pensi Shell Waste As Hydroxyapatite Composite With Biopolymer From Shrimp Shell And Peg And Its Application, Novesar Jamarun, Nabiila Ayyu Trycahyani, Upita Septiani, Vivi Sisca, Muhammad Refki Novesar, Sri Mulya

Baghdad Science Journal

This study focuses on the synthesis, structural analysis and antibacterial properties of a composite comprising hydroxyapatite (HAp), polyethylene glycol (PEG) and chitosan (CTS). CTS was extracted from shrimp shells, and CaO for Hap was obtained from pensi shell. These composites were synthesized using the sol-gel method in situ by varying the concentrations of PEG (5, 10, 15, 20 and 25%) and CTS (1, 2, 3, 4, and 5%). The synthesized composites were characterized using FTIR, XRD, SEM-EDX, and TGA-DTA analyses, and their antimicrobial activities were also evaluated. The HAp-PEG-Chitosan composite with 5% chitosan and 10% PEG was identified as the …

Isolation And Identification Of Airborne Bacteria Within The University Of Baghdad Campus, Iraq By Using 16s Rrna Gene Technique, Shahad Emad Muheisen, Israa Mohsin Jasim, Fouad K. Mashee Al-Ramahi

Baghdad Science Journal

This study aimed to identify and classify airborne bacteria in outdoor air within the campus of the University of Baghdad, Iraq, using the passive sampling technique. Air samples were collected from ten sites and analyzed by the 16S rRNA gene sequencing technique. The results revealed significant seasonal differences in both microbial and particulate matter concentrations. Bacterial concentrations were considerably higher during the wet season, with 3238.6 CFU/m³ compared to the dry season, with 1872.6 CFU/m³. PM2.5 levels averaged 47.58 μg/m³ in the wet season and declined to 11.33 μg/m³ in the dry season, while PM10 …

Molecular Characterization And Virulence Factors Of Streptococcus Mutans Isolated From Dental Caries In Type 2 Diabetic Patients, Tiba Abed Maarij Al-Ogaidi, Shaymaa Ismael Kadhim Al-Juboori

Baghdad Science Journal

Individuals with type 2 diabetes are particularly susceptible to frequent and uncontrolled dental caries. Streptococcus mutans, a main cause of dental caries, impacts millions each year and presents significant oral health challenges. Although extensively studied, the bacterium's pathogenesis remains incompletely understood, underscoring the need for further research. This study aimed to isolate and analyze the molecular characteristics of Streptococcus mutans in patients with type 2 diabetes. It explored the bacterium's capacity to infect, survive, and endure acidic oral environments. Samples were taken from 50 individuals with both type 2 diabetes and dental caries, 50 with dental plaque, and 20 …

Maternal Genetic Structure Of Iraqi Faili Kurds Revealed Using Whole Mitochondrial Genome Sequencing, Mayyadah Khalid Ibrahim, Suhaili Abu Bakar, Cheah Yoke Kqueen, Majeed Arsheed Sabbah

Baghdad Science Journal

Mitochondrial DNA (mtDNA) is a commonly utilized genetic marker in determining maternal ancestry because of the hypervariable regions in it, as well as haplogroups, which enable scientists to establish ancestral links among populations. This research involved the analysis of the complete mitochondrial genome of 100 Faili Kurd women in different cities in Iraq using the Illumina system. The most common haplogroups were HV14 (53%), H14a (16%), M37e2 (16%), and HV2a1*1 (15%). The pair-wise AMOVA-FST analysis in terms of population revealed that there were various levels of genetic differentiation between Faili Kurds and other populations in Iraq, Iran, and surrounding areas. …