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2021

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Enhancing Mental Toughness In Student-Athletes During The Covid-19 Pandemic Via Educational-Based Psychological Skills Training: Preliminary Results Of A Pilot Study, Madison Giuliani, Grant Morgan, Richard G. Cowden, Jeff S. Forsse, Andreas Stamatis Dr. Feb 2021

Enhancing Mental Toughness In Student-Athletes During The Covid-19 Pandemic Via Educational-Based Psychological Skills Training: Preliminary Results Of A Pilot Study, Madison Giuliani, Grant Morgan, Richard G. Cowden, Jeff S. Forsse, Andreas Stamatis Dr.

International Journal of Exercise Science: Conference Proceedings

One group of measures against the COVID-19 pandemic have been the non-pharmaceutical interventions (NPIs). NPIs taken by the NCAA included suspension of athletic seasons. Suspended championships during the pandemic have decimated the world of sports and led to changes in athletic role identity and social connectedness, which negatively affected student-athletes’ mental health (MH). One psychological characteristic that has the potential to support the MH and well-being of athletes is mental toughness (MT). MT is associated with successful sport performance and positive MH outcomes. Although empirical evidence supports the effectiveness of educational-based psychological skills training (PST) in promoting MH, similar effects …


An Extended Period Of Carbohydrate Mouth Rinsing Prior To Consumption Has No Additive Benefit On Cycling Performance, Henry D. Gebhardt, Eric J. Jones, Dustin P. Joubert Feb 2021

An Extended Period Of Carbohydrate Mouth Rinsing Prior To Consumption Has No Additive Benefit On Cycling Performance, Henry D. Gebhardt, Eric J. Jones, Dustin P. Joubert

International Journal of Exercise Science: Conference Proceedings

Due to limited glycogen stores, carbohydrate (CHO) consumption during exercise is effective at improving performance in endurance events lasting longer than 90 minutes in duration. Recent research has established that CHO mouth rinsing may improve performance over shorter durations, independent of actual consumption. However, research is lacking in determining if an extended period of mouth rinsing has any additive benefit in conjunction with typical CHO beverage consumption over longer competition durations, where CHO ingestion/consumption is likely warranted. PURPOSE: Determine the effects of CHO mouth rinsing combined with consumption compared to CHO consumption alone on cycling performance. METHODS: Following …


Achilles Tendon Rupture – Young Adult Female Volleyball Player, Katie M. Botterbusch, Lisa A. Vicencio, Abigail G. Seamans, Andreas Stamatis Dr. Feb 2021

Achilles Tendon Rupture – Young Adult Female Volleyball Player, Katie M. Botterbusch, Lisa A. Vicencio, Abigail G. Seamans, Andreas Stamatis Dr.

International Journal of Exercise Science: Conference Proceedings

CASE HISTORY: A 25-year-old professional volleyball player, who was playing in a game in Iceland, was transitioning off the net back-pedaling and pivoting as she felt something pop in her right calf. Initially, the athlete denied having any pain but was unable to plantarflex her foot or weight bear. At the time of injury, she was taking Sertraline (HCL 50 mg), Trazodone (50 mg), Wellbutrin XL (Bupropion HCL) 150 mg, Adderall (5mg) and birth control. PHYSICAL EXAM: The athlete was evaluated at an emergency room, where a Thompson squeeze test was performed and determined positive for an acute Achilles tendon …


Metabolic And Body Composition Changes After Skin Reduction Surgery Following Massive Weight Loss, Patrick S. Harty, Richard Allen Stecker Mr., Grant M. Tinsley, Chad Kerksick Feb 2021

Metabolic And Body Composition Changes After Skin Reduction Surgery Following Massive Weight Loss, Patrick S. Harty, Richard Allen Stecker Mr., Grant M. Tinsley, Chad Kerksick

International Journal of Exercise Science: Conference Proceedings

CASE HISTORY: The patient is a 30-year-old woman who lost more than 200 pounds over the course of several years through a combination of bariatric surgery, diet, and exercise. Generally, losing more than 100 pounds leaves patients with significant amounts of excess tissue and loose skin that must be corrected via skin reduction plastic surgery to support aesthetic and functional outcomes. This excess tissue also contributes to abnormal body composition results and could potentially influence resting metabolic rate. This case study examined the implications of skin reduction surgery on measures of body composition and resting metabolism. The patient presented …


Discovering The Accuracy Of Popular Mobile Applications In Predicting Resting Energy Expenditure In Humans, Matthias Tinnin, Hannah John, Jessica Prather, Shay Smith, Christine Harrison, Rachel Robinson, Hunter Taylor, Steven Alvarez, Stacie Urbina, Javier A. Zaragoza, Ariane Secrest, Lemuel W. Taylor Iv Feb 2021

Discovering The Accuracy Of Popular Mobile Applications In Predicting Resting Energy Expenditure In Humans, Matthias Tinnin, Hannah John, Jessica Prather, Shay Smith, Christine Harrison, Rachel Robinson, Hunter Taylor, Steven Alvarez, Stacie Urbina, Javier A. Zaragoza, Ariane Secrest, Lemuel W. Taylor Iv

International Journal of Exercise Science: Conference Proceedings

Calorie tracking applications are commonly used by athletes and the general population to monitor their nutritional intake. Users depend on the accuracy of these applications in order to achieve goals relating to performance or body composition. Resting energy expenditure (REE) is the minimum number of calories the body would need to maintain its function for a 24-hour period of non-activity and the largest component of total daily energy expenditure (TDEE). Although these applications are trusted and used on a daily basis, there is little data to support or disprove their accuracy. PURPOSE: The purpose of this study was to …


The Ethical Principles Of Financial Wellness And Coaching For Law Enforcement, Eric Scovil Feb 2021

The Ethical Principles Of Financial Wellness And Coaching For Law Enforcement, Eric Scovil

Master of Arts in Criminal Justice Leadership

The implementation of wellness programs in law enforcement today is quickly becoming a primary focus of departments throughout the nation. Implementation of a financial coaching program as a component of a holistic officer wellness program can serve to greatly reduce one of the single largest causes of stress in society; money. One of the hallmarks of successful public safety is planning and preparation for the unknown. Individuals armed with practical knowledge and well-defined financial plans are better suited to confront personal and professional decisions with a clear mind and eyes fixed on the future. Successful implementation of a financial coaching …


Examining The Causal Impact Of Prenatal Home Visiting On Birth Outcomes: A Propensity Score Analysis, Elizabeth R. Anthony, Robert L. Fischer Feb 2021

Examining The Causal Impact Of Prenatal Home Visiting On Birth Outcomes: A Propensity Score Analysis, Elizabeth R. Anthony, Robert L. Fischer

Faculty Scholarship

Objectives: In Ohio, African American babies die at 2.5–3 times the rate of White babies. Preterm birth and low birth weight are the leading causes of infant mortality. Home visiting is an evidence-based strategy for serving low-income pregnant women; however, there are relatively few rigorous studies examining its effect on birth outcomes. Methods: This study uses a propensity score technique to estimate the causal effect of participation in home visiting on prematurity and low birth weight among a low-income, predominantly African American sample (N = 26,814). Results: We found that participation in home visiting significantly reduced the odds of experiencing …


The Utah Statesman, February 22, 2021, Utah State University Feb 2021

The Utah Statesman, February 22, 2021, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.


Nine Speakers Slated For 2021 Tedxuniversityofmississippi Event, Edwin B. Smith Feb 2021

Nine Speakers Slated For 2021 Tedxuniversityofmississippi Event, Edwin B. Smith

University of Mississippi News

Presenters will address theme of 'Resilience' during in-person forum at Ford Center


The Echo: February 22, 2021, Taylor University Feb 2021

The Echo: February 22, 2021, Taylor University

2020-2021 (Volume 108)

How Taylor celebrates MLK Jr. Day — Taylor and quarantine food distribution — Study abroad programs prioritize student safety — Counseling center hosts free couples workshop — Upland businesses plow through heavy winter — PeRT communication — Is social media censorship legal? — Depressed? Anxious? Try eating spinach. — Modern Solutions Required — Motivation Monday — Boredom Stoppers — Humans of TU — Couples give clothes a second chance — Nostalgia Night 2021 invites summer — Student artist showcases abstract art — “Evermore” albums cements new era of Taylor Swift’s music — Spring football at Turner around the corner — …


The Guardian, Week Of February 22, 2021, Wright State Student Body Feb 2021

The Guardian, Week Of February 22, 2021, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of February 22, 2021. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.


Distress Screenings For Oncology Patients, A Best Practice Approach, Alexandra Monell, Stephanie Bonanno, Ebony M. Samuel-Bakpessi, Kathleen Joy, Yrina Sosa, Judith Maloy Feb 2021

Distress Screenings For Oncology Patients, A Best Practice Approach, Alexandra Monell, Stephanie Bonanno, Ebony M. Samuel-Bakpessi, Kathleen Joy, Yrina Sosa, Judith Maloy

Creating Healthy Work Environments (CHWE)

The impact of distress can have consequences that are devastating for patients with cancer, especially during an unforeseen pandemic. The specific aim of this study identifies the efficacy of using the Distress Screening Tool during every oncology patients’ treatment visit, advocating for them, and linking them to the appropriate resources.


Maternal Dietary Quality, Inflammatory Potential And Childhood Adiposity: An Individual Participant Data Pooled Analysis Of Seven European Cohorts In The Alphabet Consortium, Ling-Wei Chen, Adrien M. Aubert, Nitin Shivappa, Jonathan Y. Bernard, Sara M. Mensink-Bout, Aisling A. Geraghty, John Mehegan, Matthew Suderman, Kinga Polanska, Wojciech Hanke, Agnieszka Jankowska, Caroline L. Relton, Sarah R. Crozier, Nicholas C. Harvey, Cyrus Cooper, Mark Hanson, Keith M. Godfrey, Romy Gaillard, Liesbeth Duijts, Barbara Heude, James Hébert Scd, Fionnuala M. Mcauliffe, Cecily Kelleher, Catherine M. Phillips Feb 2021

Maternal Dietary Quality, Inflammatory Potential And Childhood Adiposity: An Individual Participant Data Pooled Analysis Of Seven European Cohorts In The Alphabet Consortium, Ling-Wei Chen, Adrien M. Aubert, Nitin Shivappa, Jonathan Y. Bernard, Sara M. Mensink-Bout, Aisling A. Geraghty, John Mehegan, Matthew Suderman, Kinga Polanska, Wojciech Hanke, Agnieszka Jankowska, Caroline L. Relton, Sarah R. Crozier, Nicholas C. Harvey, Cyrus Cooper, Mark Hanson, Keith M. Godfrey, Romy Gaillard, Liesbeth Duijts, Barbara Heude, James Hébert Scd, Fionnuala M. Mcauliffe, Cecily Kelleher, Catherine M. Phillips

Faculty Publications

Background

Mounting evidence suggests that maternal diet influences pregnancy and birth outcomes, but its contribution to the global epidemic of childhood obesity has not as yet been definitively characterized. We investigated whether maternal whole diet quality and inflammatory potential influence childhood adiposity.

Methods

We harmonized and pooled individual participant data from 16,295 mother-child pairs in seven European birth cohorts. Maternal pre-, early-, late-, and whole-pregnancy (any time during pregnancy) dietary quality and inflammatory potential assessed with the Dietary Approaches to Stop Hypertension (DASH) score and the energy-adjusted Dietary Inflammatory Index (E-DII™) score, respectively. Primary outcome was childhood overweight and obesity …


Metabolic Flexibility Across The Spectrum Of Glycemic Regulation In Youth, Fida Bacha, Sara Klinepeter Bartz, Maurice Puyau, Anne Adolph, Susan Sharma Feb 2021

Metabolic Flexibility Across The Spectrum Of Glycemic Regulation In Youth, Fida Bacha, Sara Klinepeter Bartz, Maurice Puyau, Anne Adolph, Susan Sharma

Children’s Nutrition Research Center Staff Publications

BACKGROUNDMetabolic flexibility (MF) refers to the relative ability to utilize lipid and carbohydrate substrates and to transition between them. It is not clear whether MF is impaired in obese youth and what the determining factors are.METHODSWe investigated the determinants of MF (increased respiratory exchange ratio [ΔRER] under insulin-stimulated conditions) in pubertal youth (n = 104; 15.6 ± 1.8 years) with obesity across the spectrum of glucose tolerance compared with normal weight (NW) controls, including body composition (fat-free mass [FFM], %body fat), visceral adipose fat (VAT) (MRI), glycemia, and insulin sensitivity (IS) [3-hour hyperinsulinemic-euglycemic clamp with measurement of lipolysis ([2H5] glycerol), …


U.S. Housing Relief During Covid: Successes And Failures - And What Policymakers Can Do, Gabriel Bildirici Feb 2021

U.S. Housing Relief During Covid: Successes And Failures - And What Policymakers Can Do, Gabriel Bildirici

Cardozo International & Comparative Law Review (CICLR) Blog

Housing insecurity has increased drastically since the onset of the coronavirus pandemic last year. Millions have lost their incomes, forcing people to fall behind on rent. At this point, there is a federal eviction moratorium and many states and cities have their own eviction moratoriums aimed at stopping evictions during these critical months as the United States is combating the highest amount of cases and deaths across the nation.

This post was originally published on the Cardozo International & Comparative Law Review website on February 22, 2021. The original post can be accessed via the Archived Link button above.


A Public Health Approach For Deciding Policy On Infant Feeding And Mother-Infant Contact In The Context Of Covid-19, Nigel Rollins, Nicole Minckas, Fyezah Jehan, Rakesh Lodha, Daniel Raiten, Claire Thorne, Philippe Van De Perre, Mija Ververs, Neff Walker, Rajiv Bahl Feb 2021

A Public Health Approach For Deciding Policy On Infant Feeding And Mother-Infant Contact In The Context Of Covid-19, Nigel Rollins, Nicole Minckas, Fyezah Jehan, Rakesh Lodha, Daniel Raiten, Claire Thorne, Philippe Van De Perre, Mija Ververs, Neff Walker, Rajiv Bahl

Department of Paediatrics and Child Health

The COVID-19 pandemic has raised concern about the possibility and effects of mother-infant transmission of SARS-CoV-2 through breastfeeding and close contact. The insufficient available evidence has resulted in differing recommendations by health professional associations and national health authorities. We present an approach for deciding public health policy on infant feeding and mother-infant contact in the context of COVID-19, or for future emerging viruses, that balances the risks that are associated with viral infection against child survival, lifelong health, and development, and also maternal health. Using the Lives Saved Tool, we used available data to show how different public health approaches …


A Bibliography On Socio-Economic And Cultural Impacts Of Covid-19 Pandemic, Lungi Mthethwa, Simeon Ambrose Nwone Feb 2021

A Bibliography On Socio-Economic And Cultural Impacts Of Covid-19 Pandemic, Lungi Mthethwa, Simeon Ambrose Nwone

Library Philosophy and Practice (e-journal)

The study compiled bibliographic reference sources on the socio-economic and cultural impacts of coronavirus (Covid-19) pandemic around the world. The paper filled a crucial knowledge gap in LIS literature due to paucity of bibliographic information sources on this contemporary topic. The bibliographic materials focused on books, e-books, journals, newspaper, news, reports and reviews, thesis and dissertation, with subjects on any or the combination of social, economic and cultural impacts of Covid-19 across the world. The scope of the literatures was limited to publications in the year 2020 as most articles where produced during that period in response to the Covid-19 …


A Scientometric Analysis Of Highly Cited Works On Herbal Drugs, Medicines And Vaccines, Surulinathi Muthuraj, Jayasuriya T Mlis, Duraipandi R Assistant Librarian, Senthamilselvi A Assistant Professor Feb 2021

A Scientometric Analysis Of Highly Cited Works On Herbal Drugs, Medicines And Vaccines, Surulinathi Muthuraj, Jayasuriya T Mlis, Duraipandi R Assistant Librarian, Senthamilselvi A Assistant Professor

Library Philosophy and Practice (e-journal)

The present study aims to analyse the research output performance on Herbal Drugs, Medicines and Vaccines. A total of 973 research articles published in Web of Science database were analysed to find out the performance of Herbal Medicines, Drugs and Vaccines developers from all over the world in terms of growth of Publications and Citations impact during the period 1989-2021. Global publication shares, prolific author in the field, high productive Institutions, Journals, are studied in this article. The top most cited countries are: USA with 64799 Citations for 288 (29.6%) Publications followed by People R China with 29264 Citations for …


Hearing Threshold Levels Of Australian Coal Mine Workers: A Retrospective Cross-Sectional Study Of 64196 Audiograms, Adelle Liebenberg, Alan M. Brichta, Valerie M. Nie, Sima Ahmadi, Carole L. James Feb 2021

Hearing Threshold Levels Of Australian Coal Mine Workers: A Retrospective Cross-Sectional Study Of 64196 Audiograms, Adelle Liebenberg, Alan M. Brichta, Valerie M. Nie, Sima Ahmadi, Carole L. James

Research outputs 2014 to 2021

Objective: This study examined the hearing threshold levels (HTL) of workers commencing employment in Australian coal mines in the State of New South Wales (NSW). The aim was to establish if some degree of hearing loss was identifiable in the mandatory pre-employment audiograms of workers.

Design: This was an observational, retrospective, repeated cross-sectional study. Study Sample De-identified audiometric records of 64196 employees entering NSW coal mining in three representative five-year periods between 1991–2015 were utilised

Results: Although HTLs were lower (better) in more recent years, the results showed clinically significant hearing loss ( ≥ 25dBHL) for older workers, 45–60 years. …


Estimating The Lactate Threshold Using Wireless Near-Infrared Spectroscopy And Threshold Detection Analyses, Trent E. Cayot, Shara G. Robinson, Lindsay E. Davis, Paul A. Bender, John R. Thistlethwaite, Craig E. Broeder, Jakob D. Lauver Feb 2021

Estimating The Lactate Threshold Using Wireless Near-Infrared Spectroscopy And Threshold Detection Analyses, Trent E. Cayot, Shara G. Robinson, Lindsay E. Davis, Paul A. Bender, John R. Thistlethwaite, Craig E. Broeder, Jakob D. Lauver

International Journal of Exercise Science

International Journal of Exercise Science 14(4): 284-294, 2021. The present investigation examined the ability of two threshold detection analyses (maximum distance, Dmax; modified maximum distance, mDmax) in identifying the near-infrared spectroscopy (NIRS) threshold, a lactate threshold (LT) estimate, from exercising tissue oxygen saturation (StO2) responses. Additionally, the test-retest reliability of exercising StO2 and total hemoglobin concentration (THC) responses were examined at moderate and peak cycling intensities. Fourteen healthy, recreationally active participants performed maximal incremental step cycling tests (+25 W / 3 minutes) to volitional fatigue on two separate occasions while StO2 and THC of the vastus …


The Effects Of Social Spending On Entrepreneurship In Developed Nations, Shelby Solomon, Joshua S. Bendickson, Eric W. Liguori Feb 2021

The Effects Of Social Spending On Entrepreneurship In Developed Nations, Shelby Solomon, Joshua S. Bendickson, Eric W. Liguori

Rohrer College of Business Departmental Research

Understanding how national policy can spur entrepreneurial activity is central to entrepreneurship research. Over the past decade, there has been a limited set of research findings to suggest that social spending may increase entrepreneurship in addition to serving more direct social purposes. We examine the topic through the lens of market failure theory and Austrian economics. In accordance with the Austrian perspective, we theorize that social spending increases the opportunity cost of entrepreneurship, thereby decreasing the attractiveness of entrepreneurship in comparison to salaried employment. Drawing from a sample of 31 developed countries spanning 2004–2011, we investigate the effects of social …


Removal Of Epididymal Visceral Adipose Tissue Prevents Obesity-Induced Multi-Organ Insulin Resistance In Male Mice, Michael P Franczyk, Mai He, Jun Yoshino Feb 2021

Removal Of Epididymal Visceral Adipose Tissue Prevents Obesity-Induced Multi-Organ Insulin Resistance In Male Mice, Michael P Franczyk, Mai He, Jun Yoshino

2020-Current year OA Pubs

Obesity is associated with insulin resistance, an important risk factor of type 2 diabetes, atherogenic dyslipidemia, and nonalcoholic fatty liver disease. The major purpose of this study was to test hypothesize that prophylactic removal of epididymal visceral adipose tissue (VAT) prevents obesity-induced multi-organ (liver, skeletal muscle, adipose tissue) insulin resistance. Accordingly, we surgically removed epididymal VAT pads from adult C57BL/6J mice and evaluated in vivo and cellular metabolic pathways involved in glucose and lipid metabolism following chronic high-fat diet (HFD) feeding. We found that VAT removal decreases HFD-induced body weight gain while increasing subcutaneous adipose tissue (SAT) mass. Strikingly, VAT …


Strategies For Change: Motivation & Rewards, Kayce Hyde Feb 2021

Strategies For Change: Motivation & Rewards, Kayce Hyde

Diet, Food, Exercise, and Nutrition (D-FEND)

Kayce Hyde speaks about motivation and how we can initiate, guide and maintain goal-oriented behaviors.


Recent Advances In The Application Of Crispr/Cas9 Gene Editing System In Poultry Species, Collins N. Khwatenge, Samuel N. Nahashon Feb 2021

Recent Advances In The Application Of Crispr/Cas9 Gene Editing System In Poultry Species, Collins N. Khwatenge, Samuel N. Nahashon

Agricultural and Environmental Sciences Faculty Research

CRISPR/Cas9 system genome editing is revolutionizing genetics research in a wide spectrum of animal models in the genetic era. Among these animals, is the poultry species. CRISPR technology is the newest and most advanced gene-editing tool that allows researchers to modify and alter gene functions for transcriptional regulation, gene targeting, epigenetic modification, gene therapy, and drug delivery in the animal genome. The applicability of the CRISPR/Cas9 system in gene editing and modification of genomes in the avian species is still emerging. Up to date, substantial progress in using CRISPR/Cas9 technology has been made in only two poultry species (chicken and …


Biodegradable Cellulose Film Prepared From Banana Pseudo-Stem Using An Ionic Liquid For Mango Preservation, Binling Ai, Lili Zheng, Wenqi Li, Xiaoyan Zheng, Yang Yang, Dao Xiao, Jian Shi, Zhanwu Sheng Feb 2021

Biodegradable Cellulose Film Prepared From Banana Pseudo-Stem Using An Ionic Liquid For Mango Preservation, Binling Ai, Lili Zheng, Wenqi Li, Xiaoyan Zheng, Yang Yang, Dao Xiao, Jian Shi, Zhanwu Sheng

Biosystems and Agricultural Engineering Faculty Publications

The excessive use and disposal of plastic packaging materials have drawn increasing concerns from the society because of the detrimental effect on environment and ecosystems. As the most widely used fruit packing material, polyethylene (PE) film is not suitable for long-term preservation of some tropical fruits, such as mangos, due to its inferior gas permeability. Cellulose based film can be made from renewable resources and is biodegradable and environmental-friendly, which makes it a promising alternative to PE as a packaging material. In this study, cellulose film synthesized from delignified banana stem fibers via an ionic liquid 1-Allyl-3-methylimidazolium chloride ([AMIm][Cl]) were …


Unh Pathologist Finds Mill River Dolphin Had Parasitic Brain Infection, Lori Tyler Gula Feb 2021

Unh Pathologist Finds Mill River Dolphin Had Parasitic Brain Infection, Lori Tyler Gula

Media Relations

No abstract provided.


Daily Eastern News: February 19, 2021, Eastern Illinois University Feb 2021

Daily Eastern News: February 19, 2021, Eastern Illinois University

February

No abstract provided.


2021 February 19 - Board Of Trustees Academic, Research, And Student Success Committee Agenda And Minutes, Board Of Trustees, East Tennessee State University Feb 2021

2021 February 19 - Board Of Trustees Academic, Research, And Student Success Committee Agenda And Minutes, Board Of Trustees, East Tennessee State University

Board of Trustees Agendas and Minutes

No abstract provided.


Vitamin D Supplementation Among Bangladeshi Children Under-Five Years Of Age Hospitalised For Severe Pneumonia: A Randomised Placebo Controlled Trial, Fahmida Chowdhury, Abu Sadat Mohammad Sayeem Bin Shahid, Mosharrat Tabassum, Irin Parvin, Probir Kumar Ghosh, Mohammad Iqbal Hossain, Nur Haque Alam, A. S. G. Faruque, Sayeeda Huq, Lubaba Shahrin, Nusrat Homaira, Zakiul Hassan, Zubair Akhtar, S. Mah-E-Muneer, George J. Fuchs Iii, Tahmeed Ahmed, Mohammod Jobayer Chisti Feb 2021

Vitamin D Supplementation Among Bangladeshi Children Under-Five Years Of Age Hospitalised For Severe Pneumonia: A Randomised Placebo Controlled Trial, Fahmida Chowdhury, Abu Sadat Mohammad Sayeem Bin Shahid, Mosharrat Tabassum, Irin Parvin, Probir Kumar Ghosh, Mohammad Iqbal Hossain, Nur Haque Alam, A. S. G. Faruque, Sayeeda Huq, Lubaba Shahrin, Nusrat Homaira, Zakiul Hassan, Zubair Akhtar, S. Mah-E-Muneer, George J. Fuchs Iii, Tahmeed Ahmed, Mohammod Jobayer Chisti

Pediatrics Faculty Publications

INTRODUCTION: Vitamin D is important for its immunomodulatory role and there is an independent association between vitamin D deficiency and pneumonia. We assessed the effect of vitamin D supplementation on the outcome in children hospitalized for severe pneumonia.

METHODS: This was a randomised, double blinded, placebo-controlled clinical trial in children aged >2–59 months with severe pneumonia attending Dhaka Hospital, icddr,b. Children received age-specific megadose of vitamin D3 (20,000IU: < 6 months, 50,000 IU: 6–12 months, 100,000 IU:13–59 months) or placebo on first day and 10,000 IU as maintenance dose for next 4 days or until discharge (if discharged earlier) along with standard therapy. This trial is registered at ClinicalTrials.gov, number NCT02185196.

FINDINGS: We enrolled 100 children in placebo group and 97 in vitamin D group. On admission, 50 (52%) and 49 (49%) of children in vitamin D and placebo groups, respectively were vitamin …


Robust Inference Of Kinase Activity Using Functional Networks, Serhan Yılmaz, Daniela M. Schlatzer, Mark R. Chance, Mehmet Koyutürk Feb 2021

Robust Inference Of Kinase Activity Using Functional Networks, Serhan Yılmaz, Daniela M. Schlatzer, Mark R. Chance, Mehmet Koyutürk

Faculty Scholarship

Mass spectrometry enables high-throughput screening of phosphoproteins across a broad range of biological contexts. When complemented by computational algorithms, phospho-proteomic data allows the inference of kinase activity, facilitating the identification of dysregulated kinases in various diseases including cancer, Alzheimer’s disease and Parkinson’s disease. To enhance the reliability of kinase activity inference, we present a network-based framework, RoKAI, that integrates various sources of functional information to capture coordinated changes in signaling. Through computational experiments, we show that phosphorylation of sites in the functional neighborhood of a kinase are significantly predictive of its activity. The incorporation of this knowledge in RoKAI consistently …