Digital Commons Network^™

Head Trauma Not Associated With Long Term Effects On Autonomic Function, Carley A. Shannon, Kimberli L. Pike, Sydney R. Dejonge, Paul R. Nagelkirk, Andrew T. Del Pozzi

International Journal of Exercise Science

International Journal of Exercise Science 14(3): 779-790, 2021. Contact-sports can elicit concussions, which impacts autonomic function, as well as elicit repetitive head trauma, where autonomic function has not yet been assessed. The purpose of this study was to determine if differences in autonomic function exist among three groups (CTRL: healthy non-contact-sport participant, RHT: repetitive head trauma contact-sport participant, CONC: previous concussion). Forty participants (16 men and 24 women), aged 18-37 (22 ± 3), participated in the study. Participants were grouped based on their sport and concussion history (CTRL, RHT, and CONC). Body composition was measured via air displacement plethysmography. Prior …

An Investigation Of Healthcare Supports For Those With Food Allergy In Ireland, Joseph Bolger, Nicola Blake, Sneha Vinod

International Undergraduate Journal of Health Sciences

Introduction: In Ireland, around 5% of children and 3% adults have food allergy (134,000 people). This current paper describes a survey that was carried out on a subset of service-users with the aim of identifying whether there is a need for increased specialist medical services and/or for a funded charity such as Anaphylaxis Ireland, defunct since 2015.

Materials & Methods: These needs were assessed via an online survey using Google Forms. The survey was conducted from 17-27th February 2020. There were 31 questions in total, relating to topics such as symptoms, clinical wait times, satisfaction with care provided and demand …

Microangiopathic Haemolytic Anaemia Diagnosis And Management In Thrombotic Thrombocytopenic Purpura And Haemolytic Uraemic Syndrome: A Review, Adam P. Korneluk

International Undergraduate Journal of Health Sciences

Microangiopathic haemolytic anaemia (MAHA) describes non-immune haemolysis by intravascular fragmentation of red blood cells, resulting from microvascular thrombosis characteristic of thrombotic microangiopathy (TMA). TMA-associated MAHAs include several diseases but are mostly associated with thrombotic thrombocytopenic purpura (TTP) and haemolytic-uremic syndrome (HUS). TTP is caused by a severe deficiency in ADAMTS13 proteinase, responsible for regulating coagulation, either due to presence of anti-ADAMTS13 (acquired iTTP; immune-mediated) or mutations in ADAMTS13 itself (congenital cTTP). HUS is caused by abnormal and uncontrolled complement activation, either by bacterial toxin activity (typical dHUS) or lack of normal regulatory proteins (atypical aHUS). This review focuses on TTP …

Diabetes Mellitus And Immunomodulation: A Double-Edged Sword., James Harte

International Undergraduate Journal of Health Sciences

Diabetes is an endocrinological disorder characterised by chronic hyperglycaemia due to abnormalities in insulin secretion, insulin action or a combination of both. According to the International Diabetes Federation, 463 million people worldwide are living with diabetes; 700 million people will be affected by 2045. The severity of the disease is dependent on the type and the stage of progression; when not correctly managed, diabetes can lead to potentially life-threatening micro- and macrovascular complications.

Prior to the discovery of insulin in 1922, the life expectancy of children with diabetes was short and the prognosis was very poor. The advocated treatment for …

Full Issue: The International Undergraduate Journal Of Health Sciences, Volume 1, Issue 1, June 2021, Iujhs Full Issue

International Undergraduate Journal of Health Sciences

The full June 2021 issue (Volume 1, Issue 1) of the International Undergraduate Journal of Health Sciences

Association Of Ultra-Processed Food Intake With Risk Of Inflammatory Bowel Disease: Prospective Cohort Study, Neeraj Narula, Emily C L. Wong, Mahshid Dehghan, Andrew Mente, Sumathy Rangarajan, Fernando Lanas, Patricio Lopez-Jaramillo, Priyanka Rohatgi, P V M. Lakshmi, Romaina Iqbal

Community Health Sciences

Objective: To evaluate the relation between intake of ultra-processed food and risk of inflammatory bowel disease (IBD).
Design: Prospective cohort study.
Setting: 21 low, middle, and high income countries across seven geographical regions (Europe and North America, South America, Africa, Middle East, south Asia, South East Asia, and China).
Participants: 116 087 adults aged 35-70 years with at least one cycle of follow-up and complete baseline food frequency questionnaire (FFQ) data (country specific validated FFQs were used to document baseline dietary intake). Participants were followed prospectively at least every three years.
Main outcome measures: The main outcome was development of …

Promoting Youth Employment Through Enterprise Development: Lessons From The Stryde Intervention, Lemayon L. Melyoki

Business Management Review

This paper presents insights drawn from the youth enterprise initiative called Strengthening Rural Youth Development through Enterprise (STRYDE). The intervention that took place in Mbeya region, Tanzania from 2015 to 2019 had targeted more than 10,000 youths. Its central assumption was that providing entrepreneurship training coupled with mentorship would empower the targeted youths to engage in entrepreneurship or secure paid jobs. This, paper, therefore, explores the outcomes of this intervention and the attendant process. Data was collected using focus group discussions involving 74 beneficiaries. Moreover, the study used semi-structured interviews conducted with project staff to collect additional data. Using an …

Food Insecurity And Frailty Among Women With And Without Hiv In The United States: A Cross-Sectional Analysis, Judy Y. Tan, Lila A. Sheira, Edward A. Frongillo Jr., Deborah Gustafson, Anjali Sharma, Daniel Merenstein, Mardge H. Cohen, Elizabeth Golub, Andrew Edmonds, Igho Ofotokun, Margaret Fischl, Deborah Konkle-Parker, Torsten Neilands, Phyllis Tien, Sheri D. Weiser

Faculty Publications

Introduction: Frailty is frequently observed among people with HIV, and food insecurity is associated with frailty in the general population. Evidence is scarce on the associations between food insecurity and frailty among women with HIV who maybe particularly vulnerable to the impacts of food insecurity. The goal of this study was to assess associations between food insecurity and frailty among women with and without HIV.

Methods: There were 1265 participants from the Women’s Interagency HIV Study who participated in frailty assessments in2017. Frailty was measured using the Fried Frailty Phenotype, and women were subsequently categorized as robust, pre-frailor frail. …

Fruits, Frugivores, And The Evolution Of Phytochemical Diversity, Susan R. Whitehead, Gerald F. Schneider, Ray Dybzinski, Annika S. Nelson, Mariana Gelambi, Elsa Jos, Noelle G. Beckman

Biology Faculty Publications

Plants produce an enormous diversity of secondary metabolites, but the evolutionary mechanisms that maintain this diversity are still unclear. The interaction diversity hypothesis suggests that complex chemical phenotypes are maintained because different metabolites benefit plants in different pairwise interactions with a diversity of other organisms. In this synthesis, we extend the interaction diversity hypothesis to consider that fruits, as potential hotspots of interactions with both antagonists and mutualists, are likely important incubators of phytochemical diversity. We provide a case study focused on the Neotropical shrub Piper reticulatum that demonstrates: 1) secondary metabolites in fruits have complex and cascading effects for …

Role Of Lepidium Sativum In Treating Diabetes And Managing Bodily Functions’ Disorders In Rats., Gehan El-Emary

Karbala International Journal of Modern Science

: Lepidium sativum seed (LS) is a plant used globally for its medicinal effect in treating diabetes. This study examined the ability of an aqueous extract of LS to treat diabetes and manage disorders of bodily functions. It used 70 male Wistar rats, each weighing between 190 g and 200 g. Diabetes was established in the rats by injecting them with Alloxan Solution at 150 mg/kg of body weight. The rats were considered diabetic if, after 24 hours, their blood glucose levels were higher than 180 mg/dl. Diabetes caused severe alterations in their blood serum glucose (376.608 mg/dl); …

Institutional Indifference: Physical And Mental Health Challenges Of Pregnant Inmates, Menolly A. Hollabaugh

Honors Projects

The unprecedented rise in the US incarceration rate is well-documented. However, research into the historic increase in the prison population largely focuses on male prisoners. The dramatic increase in the rate of incarcerated females is often overlooked. This omission is important because women face unique challenges while incarcerated. One of the gendered differences, which affects women, physically and mentally, is pregnancy. This paper examines the current data available on the prevalence of pregnancy amongst female inmates, and data gaps and limitations. Pregnancy is distinctively difficult for incarcerated women as they navigate the stressors of the prison environment while receiving minimal …

Um Awards Six Achieving Equity Grants, Shea Stewart

University of Mississippi News

Grants to explore areas of diversity, equity, inclusion

Mountain Lions Reduce Movement, Increase Efficiency During The Covid-19 Shutdown, John F. Benson, Heather N. Abernathy, Jeff A. Sikich, Seth P.D. Riley

School of Natural Resources: Faculty Publications

1. Wildlife strongly alter behaviour in response to human disturbance; however, fundamental questions remain regarding the influence of human infrastructure and activity on animal movement. The Covid-19 pandemic created a natural experiment providing an opportunity to evaluate wildlife movement during a period of greatly reduced human activity. Speculation in scientific reviews and the media suggested that wildlife might be increasing movement and colonizing urban landscapes during pandemic slowdowns. However, theory predicts that animals should move and use space as efficiently as possible, suggesting that movement might actually be reduced relative to decreased human activity.

2. We quantified space use, movement, …

Effect Of The Lysosomotropic Agent Chloroquine On Mtorc1 Activation And Protein Synthesis In Human Skeletal Muscle, Michael S. Borack, Jared M. Dickinson, Christopher S. Fry, Paul T. Reidy, Melissa M. Markofski, Rachel R. Deer, Kristofer Jennings, Elena Volpi, Blake B. Rasmussen

Athletic Training and Clinical Nutrition Faculty Publications

BACKGROUND: Previous work in HEK-293 cells demonstrated the importance of amino acid-induced mTORC1 translocation to the lysosomal surface for stimulating mTORC1 kinase activity and protein synthesis. This study tested the conservation of this amino acid sensing mechanism in human skeletal muscle by treating subjects with chloroquine-a lysosomotropic agent that induces in vitro and in vivo lysosome dysfunction.

METHODS: mTORC1 signaling and muscle protein synthesis (MPS) were determined in vivo in a randomized controlled trial of 14 subjects (10 M, 4 F; 26 ± 4 year) that ingested 10 g of essential amino acids (EAA) after receiving 750 mg of chloroquine …

Effect Of The Lysosomotropic Agent Chloroquine On Mtorc1 Activation And Protein Synthesis In Human Skeletal Muscle, Michael S. Borack, Jared M. Dickinson, Christopher S. Fry, Paul T. Reidy, Melissa M. Markofski, Rachel R. Deer, Kristofer Jennings, Elena Volpi, Blake B. Rasmussen

All Faculty Scholarship for the College of Education and Professional Studies

Background

Previous work in HEK-293 cells demonstrated the importance of amino acid-induced mTORC1 translocation to the lysosomal surface for stimulating mTORC1 kinase activity and protein synthesis. This study tested the conservation of this amino acid sensing mechanism in human skeletal muscle by treating subjects with chloroquine—a lysosomotropic agent that induces in vitro and in vivo lysosome dysfunction.

Methods

mTORC1 signaling and muscle protein synthesis (MPS) were determined in vivo in a randomized controlled trial of 14 subjects (10 M, 4 F; 26 ± 4 year) that ingested 10 g of essential amino acids (EAA) after receiving 750 mg of chloroquine …

Non-B Dna-Forming Motifs Promote Mfd-Dependent Stationary-Phase Mutagenesis In Bacillus Subtilis, Tatiana Ermi, Carmen Vallin, Ana Gabriela Regalado García, Moises Bravo, Ismaray Fernandez Cordero, Holly Anne Martin, Mario Pedraza-Reyes, Eduardo Robleto

Life Sciences Faculty Research

Transcription-induced mutagenic mechanisms limit genetic changes to times when expression happens and to coding DNA. It has been hypothesized that intrinsic sequences that have the potential to form alternate DNA structures, such as non-B DNA structures, influence these mechanisms. Non-B DNA structures are promoted by transcription and induce genome instability in eukaryotic cells, but their impact in bacterial genomes is less known. Here, we investigated if G4 DNA-and hairpin-forming motifs influence stationary-phase mutagenesis in Bacillus subtilis. We developed a system to measure the influence of non-B DNA on B. subtilis stationary-phase mutagenesis by deleting the wild-type argF at its chromosomal …

Influence Of The Request And Purchase Of Television Advertised Foods On Dietary Intake And Obesity Among Children In China, Jinli Xian, Mao Zeng, Zhengjie Cai, Changxiao Xie, Yuqian Xie, Manoj Sharma, Yong Zhao, Zumin Shi

Environmental & Global Health Faculty Research

Background: This study aims to examine the effects of the request and purchase of Television (TV) advertised foods on children’s dietary intake, overweight and obesity in China. Methods: Data from 1417 children (aged 6–17 years) in the 2011 China Health and Nutrition Survey were analysed. The request and purchase of TV advertised foods were assessed through the frequency of children’s requests to purchase TV advertised foods and the frequency of parents’ purchases of these advertised foods, as well as the frequency of children’s purchases of TV advertised foods. The height and weight of children were measured. Logistic regression models were …

Editorial, Robert L. Smith

Michigan Reading Journal

No abstract provided.

What Role Does Stress Play In Overall Health?, Jamie Baum

Diet, Food, Exercise, and Nutrition (D-FEND)

What is Stress?

Alternative names for stress.

Types of stress.

Causes of stress.

Learning to recognize stress.

Using Brain-Breaks(R) As A Technology Tool To Increase Attitude Towards Physical Activity Among Students In Singapore, Govidasamy Balasekaran, Ahmad Arif Bin Ibrahim, Ng Yew Cheo, Phua Kia Wang, Garry Kuan, Biljana Popeska, Ming-Kai Chin, Magdalena Mo Ching Mok, Christopher R. Edginton, Ian Culpan, J. Larry Durstine Phd, Facsm, Faacvpr, Fnak

Faculty Publications

The purpose of this study was to investigate the effects of classroom-based Brain Breaks® Physical Activity Solution in Southeast Asia Singaporean primary school students and their attitude towards physical activity (PA) over a ten-week intervention. A total of 113 participants (8–11 years old) were randomly assigned to either an experimental (EG) or a control group (CG), with six classes to each group; the Brain Breaks® group (EG: six classes) and the Control group (CG: six classes). All EG members participated in a Brain Breaks® video intervention (three–five min) during academic classes and the CG continued their lessons as per normal. …

Farmers Feeding Utah: Increasing Healthy Food Access And Supporting Local Agriculture, Heidi Leblanc, Casey Coombs

Outcomes and Impact Quarterly

The need for food assistance increased by 300% among Utah families as a result of the COVID-19 pandemic. Farmers and ranchers were also adversely impacted by market losses and processing shortages. In response, Farmers Feeding Utah was developed to facilitate access to fresh agricultural produce for families in need.

Constraints Of Weight Loss As A Marker Of Bariatric Surgery Success: An Exploratory Study, Saulo Gil, Karla Goessler, Wagner S. Dantas, Igor Hisashi Murai, Carlos Alberto Abujabra Merege-Filho, Rosa Maria R. Pereira, Roberto De Cleva, Marco Aurélio Santo, John P. Kirwan, Hamilton Roschel, Bruno Gualano

Division of Basic Science Faculty Publications

Purpose: The aim of this exploratory study was to investigate whether the degree of weight loss properly reflects improvements in cardiometabolic health among patients who underwent Roux-en-Y gastric bypass. Methods: In this ancillary analysis from a clinical trial, patients were clustered into tertiles according to the magnitude of the percentage weight loss (1st tertile: “higher weight loss”: −37.1 ± 5.8%; 2nd tertile: “moderate weight loss”: −29.7 ± 1.4%; 3rd tertile: “lower weight loss”: −24.2 ± 2.3%). Delta changes (9 months after surgery-baseline) in clustered cardiometabolic risk (i.e., blood pressure index, fasting glucose, high-density lipoprotein [HDL] and triglycerides [TG]), glycated hemoglobin …

The Healthcare Costs Of Overnutrition, Ryan Hodge

Honors Projects

Obesity is a growing problem globally and domestically. Obesity is related to several chronic and noncommunicable diseases such as hypertension, type II diabetes, coronary heart disease, and some cancers. Both obesity and its related diseases are forms of overnutrition, which is the excess intake of nutrients that causes increased body fat to the point of impaired health. Using data from the Medical Expenditure Panel Survey (MEPS) from 2008-2016, this paper is the first to estimate the causal effect of overnutrition on medical expenditure by examining the effect of overnutrition diseases on health care costs, correcting for the endogeneity bias of …

Enhancing The Braden Scale Pressure Ulcer Risk Assessment In Long-Term Care Facilities: A Cohort Study, Rachel Deutsch

College of Science and Health Theses and Dissertations

The development of pressure ulcers remains challenging as they are associated with overwhelming costs, pain and suffering, prolonged hospitalization, and morbidity and mortality. In the United States, the Braden scale is the most widely used risk assessment tool among all healthcare organizations to identify high-risk individuals for pressure ulcer development. The objective of risk assessment is to detect high-risk patients, implement immediate interventions, and evaluate patients not at risk who do not require intervention. The purpose of this cohort study is to determine the pressure ulcer predictability of the Braden score in comparison to the Braden score with additional predictor …

The Number Of Bacteria, Antioxidant Capacity, And Organoleptic Properties Of Red Ginger Fried Chicken, Lismi Animatul Chisbiyah, Mazarina Devi, Issutarti Issutarti

Bulletin of Culinary Art and Hospitality

Alpinia purpurata (Vieill.) K. Schum is a spice that has the ability to inhibit bacterial growth and has a good antioxidant capacity. This study aims to determine the effect of adding Alpinia purpurata (Vieill.) K. Schum 0%, 10%, 20%, 30%, 40% on day 0, 1, and 2 on the number of bacteria, antioxidant capacity and hedonic properties which include the taste, aroma, and color of Red ginger fried chicken. This type of research was an experimental research with a completely randomized factorial design (CRD). The data obtained were then analyzed statistically using ANOVA and continued with Duncan's Multiple Range Test …

Effect Incorporated Of Oat And Corn Cob Powder On Physicochemical And Sensory Properties Of Putu Piring, Fisal Ahmad, Nur Ezzliana Ismail, Tuan Zainazor Tuan Chilek, Amir Izzwan Zamri, Mohamad Khairi Zainol, Rahijan Abdul Wahab, Mansoor Abdul Hamid

Bulletin of Culinary Art and Hospitality

The growing consumer demand for healthy food products has turned the interest of industry and researcher in the development of foods enriched with fibre source. Oat and corn cob powder is one of the fibre sources that rich in insoluble fibers, such as cellulose, hemicellulose and lignin which beneficial the consumer in many ways for a healthy diet. The objective of this study was to investigate the effect of oat and corn cob powder incorporation on the sensory acceptability and physicochemical properties of putu piring at different levels of percentage ratio of oat and corn cob (control 0% OP: 0% …

Physical And Chemistry Characteristics Of Ice Cream With Additional Bitter Melon Puree, Kukuh Saputryasto, Titi Mutiara Kiranawati, Laili Hidayati

Bulletin of Culinary Art and Hospitality

Ice cream made from added with bitter melon puree it is hoped will get a unique taste. The processing of this ice cream utilizes the abundant yield of bitter melon from an area. This study aims to examine the chemical properties (vitamin C, and β-carotene) and physical properties (viscosity, overrun, and melting power). The type of research used is experimental research. The design in this study used a completely randomized design (CRD) with one treatment, namely the addition of bitter melon puree with three percentages (50%, 40%, 30%). The data obtained were then analyzed using the ANOVA method if there …

The Influence Of Office Employees’ Eating Behaviour Due To Stress: The Case Of Universiti Malaysia Sabah Office Employees, Dg. Khairunisa Ahmad Sapawi, Ng Hui Ming

Bulletin of Culinary Art and Hospitality

It is common for stressful people to seek relief through eating their favourite foods or comfort foods. However, these foods can be unhealthy if taken too frequently. The study focuses on determining the university office employees’ choice of comfort foods and investigating the influence of stress on their eating behaviours. Among all of Universiti Malaysia Sabah office employees, 337 were selected through stratified sampling. Self-administered questionnaires were used to collect data. Descriptive and one-way ANOVA analysis were used. Findings showed most respondents were within medium level of stress. Based on the findings of IES, the differences on stress levels on …

Targeting The Apoa1 Locus For Liver-Directed Gene Therapy, Marco De Giorgi, Ang Li, Ayrea Hurley, Mercedes Barzi, Alexandria M Doerfler, Nikitha A Cherayil, Harrison E Smith, Jonathan D Brown, Charles Y Lin, Karl-Dimiter Bissig, Gang Bao, William R Lagor

Faculty, Staff and Students Publications

Clinical application of somatic genome editing requires therapeutics that are generalizable to a broad range of patients. Targeted insertion of promoterless transgenes can ensure that edits are permanent and broadly applicable while minimizing risks of off-target integration. In the liver, the Albumin (Alb) locus is currently the only well-characterized site for promoterless transgene insertion. Here, we target the Apoa1 locus with adeno-associated viral (AAV) delivery of CRISPR-Cas9 and achieve rates of 6% to 16% of targeted hepatocytes, with no evidence of toxicity. We further show that the endogenous Apoa1 promoter can drive robust and sustained expression of therapeutic …

Dietary Patterns And Hepatocellular Carcinoma Risk Among Us Adults, Iman Moussa, Rena S Day, Ruosha Li, Xianglin L Du, Ahmed O Kaseb, Prasun K Jalal, Carrie Daniel-Macdougall, Rikita I Hatia, Ahmed Abdelhakeem, Asif Rashid, Yun Shin Chun, Donghui Li, Manal M Hassan

Faculty, Staff and Student Publications

The objective of this study was to assess the association between dietary patterns and risk of hepatocellular carcinoma (HCC) among US adults in a hospital-based case-control study. We analyzed data from 641 cases and 1002 controls recruited at The University of Texas MD Anderson Cancer Center during 2001-2018. Cases were patients with a pathologically or radiologically confirmed new diagnosis of HCC; controls were cancer-free spouses of patients with cancers other than gastrointestinal, lung, liver, or head and neck cancer. Cases and controls were frequency-matched by age and sex. Dietary patterns were identified by principal component analysis. Odds ratios (ORs) and …