Digital Commons Network^™

A Novel Intervention Combining Supplementary Food And Infection Control Measures To Improve Birth Outcomes In Undernourished Pregnant Women In Sierra Leone: A Randomized, Controlled Clinical Effectiveness Trial, David Taylor Hendrixson, Kristie Smith, Patrick Lasowski, Meghan Callaghan-Gillespie, Jacklyn Weber, Peggy Papathakis, Per Ole Iversen, Aminata Shamit Koroma, Mark J. Manary

Open Access Publications

BACKGROUND: Innovations for undernourished pregnant women that improve newborn survival and anthropometry are needed to achieve the Sustainable Development Goals 1 and 3. This study tested the hypothesis that a combination of a nutritious supplementary food and several proven chemotherapeutic interventions to control common infections would increase newborn weight and length in undernourished pregnant women.

METHODS AND FINDINGS: This was a prospective, randomized, controlled clinical effectiveness trial of a ready-to-use supplementary food (RUSF) plus anti-infective therapies compared to standard therapy in undernourished pregnant women in rural Sierra Leone. Women with a mid-upper arm circumference (MUAC) ≤23.0 cm presenting for antenatal …

Future Directions For Hiv Service Delivery Research: Research Gaps Identified Through Who Guideline Development, Nathan Ford, Ingrid Eshun-Wilson, Wole Ameyan, Morkor Newman, Lara Vojnov, Meg Doherty, Elvin Geng

Open Access Publications

Nathan Ford and co-authors discuss the systematic identification of research gaps in improving HIV service delivery.

Risk Factors Leading To Pulmonary Exacerbation In Patients With Cystic Fibrosis: A Systematic Review, Danish Abdul Aziz, Syeda Khadija Fatima, Hasan Nawaz Tahir

Department of Paediatrics and Child Health

Objective: To ascertain major risk factors associated with pulmonary exacerbation and pulmonary function decline in cystic fibrosis.
Methods: The systematic review was conducted at Aga Khan University, Karachi, in September 2018, and comprised electronic search of PubMed, Ovid, Science Direct and Cumulative Index of Nursing and Allied Health Literature databases of studies conducted from January 1990 to September 2018 which were categorised into 3 sets; 1990-98, 1999-2007 and 2008-18. Studies included for review focussed on articles with pulmonary exacerbation as the health outcome indicator, and had diagnosis of cystic fibrosis as the inclusion criteria, while risk factors were the exposure …

Differential Effects Of Polyphenols On Insulin Proteolysis By The Insulin-Degrading Enzyme, Qiuchen Zheng, Micheal T. Kebede, Bethany Lee, Claire A. Krasinski, Saadman Islam, Liliana A. Wurfl, Merc M. Kemeh, Valerie A. Ivancic, Charles E. Jakobsche, Donald E. Spratt, Noel Lazo

Chemistry

The insulin-degrading enzyme (IDE) possesses a strong ability to degrade insulin and Aβ42 that has been linked to the neurodegeneration in Alzheimer’s disease (AD). Given this, an attractive IDE-centric strategy for the development of therapeutics for AD is to boost IDE’s activity for the clearance of Aβ42 without offsetting insulin proteostasis. Recently, we showed that resveratrol enhances IDE’s activity toward Aβ42. In this work, we used a combination of chromatographic and spectroscopic techniques to investigate the effects of resveratrol on IDE’s activity toward insulin. For comparison, we also studied epigallocatechin-3-gallate (EGCG). Our results show that the two polyphenols affect the …

Are Body Surface Area Based Estimates Of Liver Volume Applicable To Children With Overweight Or Obesity? An In Vivo Validation Study, Chelsea Hosey-Cojocari, Sherwin S. Chan, Chance S. Friesen, Amie Robinson, Veronica Williams, Erica Swanson, Daniel O'Toole, Jansynn Radford, Neil Mardis, Trevor N. Johnson, J. Steven Leeder, Valentina Shakhnovich

Student Publications

The liver is the primary organ responsible for clearing most drugs from the body and thus determines systemic drug concentrations over time. Drug clearance by the liver appears to be directly related to organ size. In children, organ size changes as children age and grow. Liver volume has been correlated with body surface area (BSA) in healthy children and adults and has been estimated by functions of BSA. However, these relationships were derived from "typical" populations and it is unknown whether they extend to estimations of liver volumes for population "outliers," such as children with overweight or obesity, who today …

Zinc Supplementation Improves Semen Quality In Boars, Supitcha Kaewma, Sanya Suphappornchai, Junpen Suwimonteerabutr, Nutthee Am-In, Mongkol Techakumphu

The Thai Journal of Veterinary Medicine

One of the causes of infertility in boars is nutritional deficiency. Interestingly, zinc has been used for improving semen quality in boars. Thus, the objective of this study was to investigate the effect of zinc as feed supplementation in order to improve semen quality in infertile boars. Three purebred Pietrain boars with a poor semen quality history were selected for the experiment. The semen samples were collected once a week for 4 weeks before the treatment period and the semen evaluated immediately. Fifteen grams (a total concentration of 150 ppm) of zinc were supplemented daily in the normal feed. The …

Are Body Surface Area Based Estimates Of Liver Volume Applicable To Children With Overweight Or Obesity? An In Vivo Validation Study., Chelsea Hosey-Cojocari, Sherwin S. Chan, Chance S. Friesen, Amie L. Robinson, Veronica Williams, Erica Swanson, Daniel O'Toole, Jansynn Radford, Neil J. Mardis, Trevor N. Johnson, J Steven Leeder, Valentina Shakhnovich

Manuscripts, Articles, Book Chapters and Other Papers

The liver is the primary organ responsible for clearing most drugs from the body and thus determines systemic drug concentrations over time. Drug clearance by the liver appears to be directly related to organ size. In children, organ size changes as children age and grow. Liver volume has been correlated with body surface area (BSA) in healthy children and adults and has been estimated by functions of BSA. However, these relationships were derived from "typical" populations and it is unknown whether they extend to estimations of liver volumes for population "outliers," such as children with overweight or obesity, who today …

Advances In Insects For Food And Feed, James Peter Egonyu, John Kinyuru, Forkwa Fombong, Jeremiah Ng’Ang’A, Yusuf Abdullahi Ahmed, Saliou Niassy

All Peer-Reviewed Publications

This Special Issue presents the outcomes from the 23rd African Association of Insect Scientists' Conference held in Cote D’Ivoire, in connection with similar initiatives within and outside Africa. Over 65 scientific papers from several countries, worldwide, were submitted, of which about 40 were accepted and published. The issue focused on new advances in the value chain of edible insects in Africa and beyond. An innovative light-emitting diode technology for mass harvesting of edible grasshopper has been developed. The nutrient composition of insects such as the desert locust has been evaluated. Organic waste streams have been found to affect insect productivity …

Effect Of Testosterone Enanthate Modeling Of Polycystic Ovary On Liver Irs-2 Mrna Expression In Rats: A Brief Report, Seyyed Amir Yasin Ahmadi, Mandana Beigi Boroujeni, Naser Pajouhi, Amin Hasanvand, Afshin Hasanvand, Seyed Behnamedin Jamei, Asghar Aaliehpour, Reza Nekouian

Baghdad Science Journal

There are many animal models for polycystic ovary (PCO); using exogenous testosterone enanthate is one of the methods of induction of these models. However, induction of insulin resistance should also be studied in the modeling technics. Therefore, the present study aims to investigate the expression of insulin receptor substrate (Irs)-2 mRNA in the liver tissue of rat PCO model. Nineteen Wistar rats were divided into three groups; (1) PCO modeling group (N =7) received daily 1.0 mg/100g testosterone enanthate solved in olive oil along with free access dextrose water 5%, (2) vehicle group (N =6), which handled like the PCO …

The Accumulation Risk Of Heavy Metals In Vegetables Which Grown In Contaminated Soil, Asmaa A Hamad, Khalid H Alamer, Hissah S Alrabie

Baghdad Science Journal

The present study has been carried out to estimate heavy metals mobility, bioconcentration and transfer from polluted soil to roots tissues and from roots tissues to aerial parts using bioconcentration factor and translocation factor. Soil samples and the biomass of the eight vegetable species have been collected during summer season, 2019 from four different sites in Wadi Al-Arg, Taif Governorate, KSA. In general, heavy metals content of soil samples in site III and IV have recorded elevated values compared with those of site I and II. The soil from site IV has shown the highest concentration of Mn, Ni, Cr, …

Effects Of Nitrogen And Sulfur Sprays On The Growth And Production Of Broccoli Brassica Oleracea Var. Italica L., Mushtak F. Karomi Kisko, Nabil Jwad Kadhum, Zainab Anwar Ali, Noora Saheb Abid

Baghdad Science Journal

In order to achieve optimal plant growth and production, essential nutrients must be readily available in adequate quantities and in a balanced proportion to give a good yield, especially broccoli which has health benefits that may not be found in many other plants. For this purpose, this experiment was carried out during the seasons 2019/2020 in the botanical garden of the Department of Biology, College of Science for Women, University of Baghdad, to study the effects of nitrogen and sulphur and their interaction on eight parameters reflecting the overall traits of vegetative growth, yield, and chlorophyll content of broccoli Brassica …

Effects Of Thermal And Non-Thermal Methods On The Chemical Composition And Bacterial Inactivation Of Camel Milk, Namariq Dhahir

Dissertations

Understanding the composition of camel milk coupled with studying the effects of thermal and non-thermal treatments on its components and bacterial inactivation were the general objectives of this dissertation. In the first study (Chapter 2), the gross composition of camel milk including milk protein, fat, casein, total solids, lactose, ash, and mineral content were analyzed. In addition, fatty acid profile, amino acid profile, protein fractions, and volatile compounds were evaluated as well. Our results revealed that camel milk has its unique nutrients profile. These findings make it easier for the researchers and consumers to understand some of the nutritional attributes …

Extracorporeal Membrane Oxygenation Rescue For Severe Aspiration Pneumonitis In Two Patients After Roux-En-Y Gastric Bypass Procedure, Melissa M Felinski, Daniyal Abbas, Peter A Walker, John A Primomo, Tanyaradzwa M Kajese, Biswajit Kar, Igor D Gregoric, Igor Banjac, Lisa Janowiak, Sriram Nathan, Rahat Hussain, Sheilendra S Mehta, Kulvinder S Bajwa, Shinil K Shah, Bindu Akkanti

Faculty, Staff and Student Publications

Roux-en-y gastric bypass (RYGB) is one of the most common weight loss surgical procedures performed in the United States. Early post-operative small bowel obstruction is a rare but potentially morbid, complication of RYGB. We report two patients who underwent RYGB and required subsequent treatment for a post-operative small bowel obstruction. Their post-operative course was complicated by severe aspiration pneumonitis leading to hypoxemic respiratory failure requiring rescue with femoral veno-venous extracorporeal membrane oxygenation (V-V ECMO). Both patients were successfully extubated, weaned off V-V ECMO support, and discharged to home. These cases highlight the potential role of V-V ECMO for patients who …

Sweetpotato Leaves Inhibit Lipopolysaccharide-Induced Inflammation In Raw 264.7 Macrophages Via Suppression Of Nf-Κb Signaling Pathway, Hyun-Dong Cho, Cindi Brownmiller, Harun Sorker, Shahidul Islam, Sun-Ok Lee

Food Science Faculty Publications and Presentations

Limited information is available regarding the health-promoting activities of sweetpotato leaves (SPL). The present study investigated antioxidant and anti-inflammatory effects, and phenolic contents in 29 SPL cultivars harvested in 2018 and 2019. Extracts showed total phenolic contents 9.4–23.1 mg gallic acid equivalent/g, and DPPH radical scavenging activity indicated 36.6–247.3 mM of Trolox equivalent/g. SPL extracts were identified to contain bioactive components such as, chlorogenic acid (11.7–22.1 μg/mg), 3,4-dicaffeoylquinic acid (16.3–59.9 μg/mg), 3,5-dicaffeoylquinic acid (50.9–72.7 μg/mg), chlorophyll B (6.1–12.3 μg/mg), lutein (1.9–4.9 μg/mg), chlorophyll A (2.7–4.3 μg/mg) and β-carotene (0.1 ≤ μg/mg). RAW 264.7 murine macrophage cells were pretreated with 100–200 …

Soft Camel Milk Cheese Effects Of Coagulants And Processing Conditions, Mustapha Mbye

Dissertations

In recent years, camel milk (CM) has been acknowledged for several health benefits, including anti-diabetic, hypoallergic, and other effects. Accordingly, CM may provide a complementary or a healthier alternative to bovine milk (BM). This has led to increased interest in processing CM to products like cheese, yogurt, and powders to extend its shelf-life. However, CM is difficult to coagulate into hard gels, affecting its cheese quality and consumer preference. The current research aimed to investigate the impact of different coagulants (chymosin, Withania coagulans, citric and acetic acid) on CM cheese quality and sensory attributes compared to BM cheese. It …

Delirium In Frail Older Adults, Min Ji Kwak

Faculty, Staff and Student Publications

Delirium and frailty are prevalent geriatric syndromes and important public health issues among older adults. The prevalence of delirium among hospitalized older adults ranges from 15% to 75%, while that of frailty ranges from 12% to 24%. The exact pathophysiology of these two conditions has not been clearly identified, although several hypotheses have been proposed. However, these conditions are considered to be multifactorial in etiology and are associated with inflammation related to aging, alterations in vascular systems, genetics, and nutritional deficiency. Furthermore, clinically, they are significantly associated with frailty, which increases the risk of delirium by almost two- to three-fold …

Providing Childcare, Christine Ho, Sunha Myong

Research Collection School Of Economics

Women’s economic empowerment has been hailed as one of the most remarkable revolutions in the past 50 years. Yet, women still face the lion’s share of the burden of childcare despite major progress in their education and earnings capacity. This is particularly salient in many Asian countries. This chapter proposes a synthesis of the state of knowledge on childcare and discusses policy-relevant issues applicable to the Singapore context. Selected policies are documented and lessons from the international landscape are discussed. Raising children incurs both direct costs in the form of childcare and opportunity costs in the form of career costs. …

Food Addiction And Obesity, Lisa Ling

Electronic Theses and Dissertations

The obesity rate in the U.S. adult population has increased to epidemic levels despite attempts to decrease obesity through evidence-based knowledge, clinical practice guidelines, medical interventions, and individual efforts. For certain individuals, food addiction behaviors such as food cravings, loss of control, and binge eating contribute to obesity and require a different approach to care. Little work has been done on adding the possibility of food addiction to obesity screening and treatment. This study utilized a quasi-experimental quantitative pre- and postsurvey research design based on Lewin’s change theory. Nurse practitioners were surveyed regarding the provider’s perceptions, attitudes, and beliefs about …

Management Of Obesity Using Telemedicine During The Covid-19 Pandemic, Angela A. Wang-Selfridge, Jennifer F. Dennis

Faculty and Staff Publications

Importance:

During the COVID-19 pandemic, telemedicine visits increased to provide safer access to healthcare.

Methods:

To evaluate the role of telemedicine in obesity management during COVID-19, we conducted a systematic review to identify barriers in using this approach to patient care.

Conclusion:

While necessary, the management of obesity through telemedicine was met with patient-specific and healthcare-specific barriers. Increased awareness of these barriers may allow physicians to better understand patient interactions via virtual medical visits.

It Is Time For An Oil Change: Polyunsaturated Fatty Acids And Human Health, Natalie Powell, Suman Chaudhary, Asma Zaidi

Faculty and Staff Publications

Polyunsaturated fatty acids (PUFAs) such as docosahexaneoic acid (DHA) and eicosapentaneoic acid (EPA), play a critical role in a variety of neuronal functions, including facilitating neuronal growth and differentiation, increasing the density of the neuritic network, modulating cell membrane fluidity, regulating intracellular signaling and gene expression, and exhibiting antioxidant characteristics. Dietary DHA is selectively enriched and actively retained in the central nervous system, mainly in synaptic membranes, dendrites, and photoreceptors. In this review, we highlight the myriad roles of PUFAs in brain function and human health. Diets rich in DHA are inversely proportional to cognitive decline and incidence of neurodegenerative …

Association Of Maternal Prenatal Selenium Concentration And Preterm Birth: A Multicountry Meta-Analysis, Nagendra Monangi, Huan Xu, Waqasuddin Khan, Furqan Kabir, Muhammad Imran Nisar, Aneeta Hotwani, Usma Mehmood, Ambreen Nizar, Javairia Khalid, Fyezah Jehan

Department of Paediatrics and Child Health

Background: Selenium (Se), an essential trace mineral, has been implicated in preterm birth (PTB). We aimed to determine the association of maternal Se concentrations during pregnancy with PTB risk and gestational duration in a large number of samples collected from diverse populations.
Methods: Gestational duration data and maternal plasma or serum samples of 9946 singleton live births were obtained from 17 geographically diverse study cohorts. Maternal Se concentrations were determined by inductively coupled plasma mass spectrometry analysis. The associations between maternal Se with PTB and gestational duration were analysed using logistic and linear regressions. The results were then combined using …

Mental Health Professionals Serving The Military: Who Has Access?, Nicole Marie Arcuri-Sanders, Kellie Forziat-Pytel

Educational Sciences and Organizations

Licensed counselors are underrepresented as mental health professionals (MHPs) servicing military-connected clients (service member/Veterans and their families). Mixed-methods research, conducted by the authors, highlights key viewpoints of MHPs (counselor, psychologist, and social worker) interested in working with the military and on their level of confidence in working with this population. MHPs' experiences, perspectives of their profession's responsibilities to military clients, and their role in comparison to other MHPs is explored. Findings aid in advocacy efforts for the military population to receive counseling from qualified providers and support counseling program development to increase counselor employability among this group.

Promoting Patient Engagement: A Scoping Review Of Actions That Align With The Interactive Care Model, Georgia Tobiano, Teresa Jerofke-Owen, Andrea P. Marshall

College of Nursing Faculty Research and Publications

Background

Conceptual clarity for the term patient engagement is growing. However, there is variability in patient engagement in healthcare, which could be due to the absence of models to guide practice or a myriad of organisational, nurse and patient factors. The recently developed ‘Interactive Care Model’ provides guidance on how to genuinely promote individualised patient engagement. An understanding of how to action this model in nursing is required.

Aims

The aim of this scoping review was to examine actions in the published scientific literature that align with the Interactive Care Model, in the context of nursing care of hospitalised patients. …

Are Corals Surviving Or Thriving In Highly Degraded Environments? A Reproductive And Trophic Analysis Of Scleractinian Corals, Morgan Short

All HCAS Student Capstones, Theses, and Dissertations

Amid the worldwide decline of corals, the survival of some corals in high nutrient, turbid environments, is intriguing – are they just surviving or are they thriving? This study aimed to determine how these corals acquire energy and whether that energy is sufficient to produce offspring (i.e., develop viable gametes). The nutritional sources and reproductive capacity of Siderastrea siderea in a shipping port (Port Everglades) were compared to two nearshore reefs in Florida, USA and an ex situ coral nursery. Fertility and estimated polyp fecundity were quantified using histological analysis, and water quality parameters were assessed monthly to evaluate differences …

Expandable Intravertebral Implants: A Narrative Review On The Concept, Biomechanics, And Outcomes In Traumatology., Diogo L Moura, Josue P Gabriel

Surgery Articles

Expandable intravertebral implants are self-expanding devices applied percutaneously by the posterior transpedicular approach. These devices introduce the concept of anatomical restoration of vertebral body endplates and direct anatomical reduction performed from the interior of the vertebral body with a compression fracture. This paper aims to provide a narrative review on the concept, indications, biomechanical characteristics, as well as functional and radiographic outcomes of the main expandable intravertebral implants currently available, in terms of their application to thoracolumbar spine traumatology. To this end, we performed a search in July 2021 on the MEDLINE/PubMed platform with the words "expandable intravertebral implant", "armed …

The Value And Scope Of The Term Femicide, Robert Brannon

Dignity: A Journal of Analysis of Exploitation and Violence

The term femicide is useful in naming a wide range of sexist killings of women by men, just as “genocide” and “sexual harassment” named these respective other crimes and civil violations. Definitions and example of killings that are, and are not, femicides clarify the scope of the term. A number and variety of misogynistic killings of women can be documented. There is evidence that learning of the term of femicide has helped women to see and to combat femicides in their spheres. The term femicide has been embraced by the United Nations and by eight Latin American countries to date.

No Evidence For Long-Term Carryover Effects In A Wild Salmonid Fish, Kim Birnie-Gauvin, Martin H. Larsen, Kathryn S. Peiman, Jonathan D. Midwood, Alexander D.M. Wilson, Steven J. Cooke, Kim Aarestrup

School of Biological and Marine Sciences

Early-life experiences can shape life histories and population dynamics of wild animals. To examine whether stressful stimuli experienced in early life resulted in carryover effects in later life stages, we conducted several experimental manipulations and then monitored wild fish with passive integrated transponder tags during juvenile out-migration and adult return migration. In total, 3,217 juvenile brown trout (Salmo trutta) were subjected to one of six manipulations: chase to exhaustion, thermal challenge, food deprivation, low-concentration cortisol injection, high-concentration cortisol injection, and sham injection, plus a control group. Cortisol and food deprivation treatments were previously shown to have short-term effects on juveniles, …

Fatty Acid Profile, Tocopherol Content Of Seed Oil, And Nutritional Analysis Of Seed Cake Of Wood Apple (Limonia Acidissima L.), An Underutilized Fruit-Yielding Tree Species, Shrinivas Lamani, Konerira Aiyappa Anu-Appaiah, Hosakatte Niranjana Murthy, Yaser Hassan Dewir, Hail Z. Rihan

School of Biological and Marine Sciences

The present study was aimed at analyzing the fatty acid composition, tocopherols, and physico-chemical characterization of wood apple (Limonia acidissima L.) seed oil and the nutritional profile of seed cake. The fatty acids in seed oil were analyzed by gas chromatography–mass spectrometry (GC-MS), and the total seed oil was 32.02 ± 0.08%, comprising oleic (21.56 ± 0.57%), alpha-linolenic (16.28 ± 0.29%), and linoleic acid (10.02 ± 0.43%), whereas saturated fatty acid content was 33.38 ± 0.60% including palmitic (17.68 ± 0.65%) and stearic acid (14.15 ± 0.27%). A greater amount of unsaturated fatty acids (52.37%) were noticed compared to saturated …

Circulating Fatty Acids Associated With Advanced Liver Fibrosis And Hepatocellular Carcinoma In South Texas Hispanics, Jingjing Jiao, Suet-Ying Kwan, Caroline M. Sabotta, Honami Tanaka, Lucas Veillon, Marc O. Warmoes, Philip L. Lorenzi, Ying Wang, Peng Wei, Jose Luis Almeda, Joseph B. Mccormick, Susan P. Fisher-Hoch

School of Medicine Publications

Background: Hispanics in South Texas have high rates of hepatocellular carcinoma (HCC) and nonalcoholic fatty liver disease (NAFLD). Liver fibrosis severity is the strongest predictive factor of NAFLD progression to HCC. We examined the association between free fatty acids (FA) and advanced liver fibrosis or HCC in this population.

Methods: We quantified 45 FAs in plasma of 116 subjects of the Cameron County Hispanic Cohort, 15 Hispanics with HCC, and 56 first/second-degree relatives of Hispanics with HCC. Liver fibrosis was assessed by FibroScan.

Results: Advanced liver fibrosis was significantly associated with low expression of very long chain (VLC) saturated FAs …

An Exploration Of Parental And Health Professional Perceptions Of Transition For Chronically Ill Students, Iris Robinson

Dissertations

When a young person is diagnosed with a chronic illness, it impacts every phase of the person’s life. During the stages of childhood and adolescence, school is the central socialization site for the student’s developmental and personal identity. That is why it is difficult to replace school as one of the maturing spaces for young people’s transition to adulthood. Chronic illness interrupts the normative life process for an extended period or permanently.

Engaged parents, legal and social advocacy, innovative medical research, public policy, educational workshops, and finally, the consortium of family, health, medical, educational and community support have been advocates …