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State Of Discovery, 2026, Division Of Research And Economic Development

State of Discovery South Dakota State University's Research Magazine

[Page] 2 R1 Our Way Update
[Page] 2 SDSU Research Spinoff Companies
[Page] 3 The future of agriculture
[Page] 8 Addressing the rural nursing crisis
[Page] 9 Repurposing drugs to create cancers and other diseases
[Page] 10 South Dakota's rural firefighters
[Page] 11 Natural food coloring
[Page] 12 Raising the ROI of Research
[Page] 13 Can ancient bacteria help solve one of agriculture's biggest challenges?

Observation And Reflection Of Neighborhood And Community 2026: Healthcare Access, Food Desert, And Transportation, Charmaine White, Nicholas Cominos, Hassan Yassine, Nicholas Saeedi, Maria Pacheco Martinez, Miranda Baumbick, Turner Tomatti, Ariel Wallace

Patient Education Projects

No abstract provided.

Hormonal, Cytokinetic, And Skeletal Response To A Single Weighted Vest Exercise Treatment: A Pilot Study To Determine Weighted Vest “Rucking” Treatment For Osteoporosis In Post-Menopausal Women, Eleanor Pell

Master's Theses

Osteoporosis is characterized by a deteriorating of bone tissue leading to brittleness and increased fracture risk that affects both men and women as they age. Postmenopausal women are of particular interest due to high risk of declining bone density, a characteristic of this population. Treatments for osteoporosis range from menopause hormone therapy, bisphosphonates, biologics, nutritional changes, and exercise. Load bearing exercise interventions have shown effectiveness for stimulating bone growth, but many factors such as lack of access, motivation, self-confidence or knowledge, prevent long term compliance. “Weighted vest rucking” refers to a variation of rucking, which is a form of exercise …

Minimizing Musculoskeletal Injury Risk In Health Care Professionals With Education On Physical Activity Recommendations, Emma H. Foran

Honors College Theses

Working in healthcare settings that require patient handling is physically demanding - over 80% of providers involved in patient handling report work-related musculoskeletal disorders (WMSDs). Injuries or exacerbation of a previous injury may occur if the individual cannot tolerate heavy workloads. Injuries that cause lost work time or work restrictions impact the healthcare team, may alter quality of life, and impact employee income. A practical way to minimize these effects is to prevent WMSDs. Training providers to use proper body mechanics, practice patient handling, and engage in regular exercise designed to increase muscular strength and endurance through resistance training improves …

Community Vitality: Establishing Blue Zone Based Education For Elementary Students, Eliza G. Heinrich

Honors College Theses

Blue Zones are areas of the world where people live longer and healthier lives. These areas share several key characteristics called the Power 9 (Buettner & Skemp, 2016). The goal of this study was to increase general knowledge of Blue Zones as well as the implementation of healthy habits to increase the longevity of the population of Calloway County, Kentucky through educational sessions of elementary students. Researchers involved in this study asked participants to fill out a pre-test to gauge knowledge of Blue Zones. Participants then underwent several educational sessions and activities surrounding the Power 9. Participants were then asked …

Sorghum Grain Secondary Metabolites And Underlying Genetics To Reduce Foodborne Pathogens In Poultry, Maria A. Conti

All Dissertations

The rise in antibiotic-resistant pathogens poses a threat to the poultry industry's ability to maintain animal health, prompting growing interest in alternatives to synthetic antibiotics. The use of non-tannin sorghum [Sorghum bicolor (L.) Moench] in poultry rations offers a valuable alternative, as this cereal grain has a high bioactive profile that can provide health benefits, including antimicrobial (AM) activity. The scope of this study was to examine the AM potential of non-tannin sorghum grain against Clostridium perfringens, a major foodborne pathogen that negatively impacts poultry health and production. To that end, the inhibitory effects of a non-tannin sorghum …

Reframing Health: A Phenomenological Inquiry Into The Lived Experiences Of Weight- Inclusive Healthcare Providers, Hannah Brass

Dissertations

The purpose of this phenomenological study was to understand the unique lived experiences of healthcare professionals who practiced from a weight-inclusive lens. This study was guided by the following research questions:

Q1 What is the unique lived experience of a healthcare provider practicing from a weight-inclusive lens?

Q2 What are the significant experiences that have influenced the development of weight-inclusive providers’ attitudes (i.e., thoughts, feelings, and behaviors)?

Data from these findings were analyzed using Giorgi’s (2009) descriptive phenomenological method to discover rich descriptions and themes of weight-inclusive healthcare practitioners' experiences. The study explored the significant experiences and supports that influenced …

Ai-Powered Insights In Pediatric Nephrology: Current Applications And Future Opportunities., Arwa Nada, Yamen Ahmed, Jieji Hu, Darcy K. Weidemann, Gregory H. Gorman, Eva Glenn Lecea, Ibrahim A. Sandokji, Stephen Cha, Stella Shin, Salar Bani-Hani, Sai Sudha Mannemuddhu, Rebecca L. Ruebner, Aadil Kakajiwala, Rupesh Raina, Roshan George, Rim Elchaki, Michael L. Moritz, The American Society Of Pediatric Nephrology Quality Improvement And Artificial Intelligence (Aspn Qi/Ai) Interest Group

Manuscripts, Articles, Book Chapters and Other Papers

Artificial intelligence (AI) is rapidly emerging as a transformative force in pediatric nephrology, enabling improvements in diagnostic accuracy, therapeutic precision, and operational workflows. By integrating diverse datasets-including patient histories, genomics, imaging, and longitudinal clinical records-AI-driven tools can detect subtle kidney anomalies, predict acute kidney injury, and forecast disease progression. Deep learning models, for instance, have demonstrated the potential to enhance ultrasound interpretations, refine kidney biopsy assessments, and streamline pathology evaluations. Coupled with robust decision support systems, these innovations also optimize medication dosing and dialysis regimens, ultimately improving patient outcomes. AI-powered chatbots hold promise for improving patient engagement and adherence, while …

Maternal Low-Sodium Diet Impairs Hippocampal Neurogenesis And Cognition In Adult Mouse Offspring., Xingrao Ke, Connie C. Grobe, Justin L. Grobe, Wei Yu, John J. Reho, Kaela Varberg, Robert H. Lane, Jeffrey L. Segar

Manuscripts, Articles, Book Chapters and Other Papers

Sodium (Na) homeostasis is critical for organ and cell function. Although low maternal Na intake during gestation is associated with low offspring survival rates and birth weights, the long-term impact on neurocognitive function is not known. Identifying a relationship between perinatal Na dysregulation and adult behavioral and cognitive outcomes may be important given the prevalence of both dysnatremias and neurocognitive impairment in preterm infants. This study aimed to determine the association between maternal low Na intake (LSI) and hippocampal-dependent behaviors in mice. C57BL/6J dams were fed a standard (0.30%) or low (0.04%) Na diet from postnatal day 0 until postnatal …

The Resilient Study: A Retrospective, Descriptive, Correlational Investigation Of Correlates Of Oral Endocrine Therapy Adherence In Older Women With Breast Cancer., Sunny Y. Ruggeri, Cynthia L. Russell Lippincott, Gregory L. Alexander, Rebecca J. Bartlett Ellis, Steven R. Chesnut, Lori A. Erickson

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Breast cancer is the most prevalent and costly cancer. Oral endocrine therapy (OET) improves survival rates and quality of life while reducing recurrence, mortality, morbidity, and medical costs. However, adherence to OET is challenging because OET is prescribed for 5-10 years. Determinants of OET nonadherence (NA) among women aged 65 and older remain poorly characterized. Existing studies are limited, often focusing on small, single-site samples and focusing on patient-level rather than multi-level determinants. Despite the unique needs of older women, research on OET-NA remains scarce.

OBJECTIVE: This study identified multi-level determinants of OET-NA in older women using ecological systems …

American Epilepsy Society Clinical Practice Guideline: Infantile Epilepsy., Daniel Freedman, Ifeoluwa Babatunde, Rebecca L. Morgan, Renad Abu-Sawwa, Dara Albert, Mandana Behbahani, Kevin Chapman, Erin Day Fecske, William Davis Gaillard, Monika Jones, Mary Anne Meskis, Leah Schust Myers, Kim Nye, Chima Oluigbo, Heidi H. Pfeifer, Reneé A. Shellhaas, Lindsey Thompson, Howard L. Weiner, Courtney J. Wusthoff, Elissa Yozawitz

Manuscripts, Articles, Book Chapters and Other Papers

This practice guideline from the American Epilepsy Society provides evidence-based recommendations for pharmacological, dietary, and surgical therapies for epilepsy for infants and children from 1 month of age to < 36 months. The multidisciplinary panel updated an existing systematic review, which was funded by the Patient-Centered Outcomes Research Institute and conducted by ECRI (formerly the Emergency Care Research Institute) on behalf of the Agency for Healthcare Research and Quality. The updated review used the same search strategy, inclusion/exclusion criteria, and Grading of Recommendations Assessment, Development and Education methodology, and added studies from August 2021 through September 2025 that were not in the original systematic review. As with the previous review, West syndrome and infantile spasms were excluded from this guideline, as existing treatment guidance is already available for infantile epileptic spasms. While many of the recommendations are conditional due to low certainty of evidence, the panel made two strong recommendations: (1) hemispherectomy/hemispherotomy surgery is recommended for infants and children < 36 months of age with drug resistant epilepsy secondary to select underlying lesional pathologies, including but not limited to hemimegaloencephaly, Rasmussen's encephalitis, Sturge-Weber syndrome, perinatal stroke, and hemispheric cortical dysplasia; and (2) intralobar, multilobar, or focal resections or posterior disconnections for drug-resistant focal or lesional epilepsy in this same age range. A treatment algorithm was developed based on evidence and expert opinion as part of the guideline to help place pharmacological, dietary, and surgical recommendations in a clinical context. The limited number of studies and low certainty of evidence in this population underscores the need for higher-quality data and etiology-specific treatments. More research is needed to evaluate effective therapies for infants with epilepsy, as well as the impact these therapies have on long-term developmental and mortality outcomes.

Molecular Mechanisms Of Pfas Induced Protein Dysfunction: Implications For Neurodegenerative Risk, Daisy Lee Wilson

Open Access Theses & Dissertations

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with widespread human exposure and well-established links to adverse health outcomes. However, despite increasing epidemiological and experimental evidence, the molecular mechanisms underlying PFAS-induced neurotoxicity remain incompletely defined. This dissertation investigates PFAS toxicity across biological scales, integrating protein biophysics with neuronal cell models to elucidate pathways relevant to neurodegeneration. At the molecular level, we demonstrate that PFAS disrupts the structure and function of globular proteins, including the impairment of α-lactalbumin's calcium-binding capacity and of β-lactoglobulin's retinol binding, through concentration-dependent conformational destabilization. By applying these findings to a neuronal model, we show that …

Health Disparities In El Paso's Low-Income Hispanic Communities: A Mixed-Methods Analysis Of Acculturation, Obesity Metrics, And Socio-Cultural Determinants, Karen Del Rio

Open Access Theses & Dissertations

Health disparities among low-income Hispanic immigrants in the United States are shaped by complex interactions between acculturation, structural inequality, and socio-cultural determinants that behavioral and epidemiological models have not fully explained. This dissertation examines the relationship between acculturation and obesity-related outcomes among uninsured and low-income Hispanic adults of Mexican descent in El Paso, Texas, using a three-article, sequential, explanatory, mixed-methods design grounded in Latina/o Critical Race Theory (LatCrit).Article 1 presents a systematic review of 20 peer-reviewed studies examining acculturation and obesity among Mexican Americans, finding consistent evidence that longer U.S. residence is associated with increased BMI and obesity prevalence, mediated …

Assessing The Use Of Exon-Skipping Morpholino Antisense Oligonucleotides Targeting The Different Sumo Paralogs As Enhancers Of The Antitumor Activity Of Chemotherapeutic Agents, Andrea Teresa Garcia-Morin

Open Access Theses & Dissertations

Post-translational modifications (PTMs) are critical regulators of protein function, stability, and localization, with SUMOylation emerging as a key modulator of cellular stress response and survival in cancer. Non-small cell lung cancer (NSCLC) is characterized by heightened dependence on SUMOylation to sustain pro-survival signaling, DNA repair, and resistance to chemotherapy. This dissertation investigates a novel chemosensitization strategy based on the splice-switching of SUMO transcripts in NSCLC cells using exon-skipping morpholinos (ESMs), which redirect splicing toward non-conjugatable SUMO alpha isoforms, thereby reducing global SUMOylation. We hypothesized that decreasing global SUMOylation through forced alternative splicing of SUMO transcripts would impair the stress-protective functions …

Voices Of Men In Diabetes Care: Evaluating Participant Satisfaction With A Men's Diabetes Management And Self-Care Program, Elida Herrera

Open Access Theses & Dissertations

Background: Hispanic populations in the US experience higher diabetes prevalence, yet Hispanic men participate in traditional diabetes education programs at lower rates than non-Hispanic White men and Hispanic women, in part because existing programs lack cultural and gender-relevant tailoring. To address this disparity, the Diabetes Garage (DG) program was developed for Hispanic men in Southwest Texas, leveraging car culture by using automotive maintenance analogies to illustrate diabetes self-management concepts to engage men. Purpose: To evaluate participant satisfaction with the DG program among cohorts participating across three predominantly Hispanic communities and to examine their personal opinions on their program experience. Methods: …

Computational Studies Of Alpha-Lactalbumin Binding To Perfluorodecanoic Acid, Randhal Smith Ramirez Orozco

Open Access Theses & Dissertations

This thesis investigates the structural and thermodynamic interactions between Perfluorodecanoic acid (PFDA) and bovine alpha-lactalbumin (ALAC), a critical milk protein essential for infant nutrition. The primary objectives were to computationally determine the most probable binding sites of PFDA to ALAC and to quantify the strength of these interactions alongside the structural changes they induce. This study addresses a critical gap in understanding how persistent environmental contaminants like PFDA are recruited and transported by nutritional proteins within the milk matrix. The methodology integrated high-throughput molecular docking with long-range, molecular dynamics (MD) simulations to provide a dynamic characterization of the ALAC-PFDA complex. …

Caregiver Experiences During Mealtime In Families Of Children With Feeding Disorders In The Borderland, Chyanne Reveles

Open Access Theses & Dissertations

This study examines the lived experiences of caregivers of children with pediatric feeding disorders (PFDs) in the Paso del Norte Region using interpretative phenomenological analysis (IPA). Pediatric feeding disorders require sustained medical, social, and emotional demand, often placing caregivers in complex decision-making roles. Understanding how cultural beliefs and context shape caregiving practices is essential to improving services provided by speech-language pathologists and other service providers. The qualitative research approach used facilitated the discovery of themes surrounding the lived experience of the caregivers of children with feeding disorders. Semi-structured interviews were conducted via Zoom with caregivers residing in the U.S.-Mexico border …

High-Resolution Mapping Of Brainstem Feeding Circuits: A Framework For Targeted Neuroscience Tools, Geronimo Tapia

Open Access Theses & Dissertations

The neural control of energy balance is mediated in part by distributed brainstem circuits that integrate metabolic, visceral, and hormonal signals to coordinate appropriate motivated behaviors and autonomic responses. Despite extensive study, the precise neuroanatomical architecture regulating metabolism remains incompletely defined within standardized atlas frameworks. This work addresses that gap through complementary studies examining an acute glycemic challenge methodology known to stimulate feeding, the acute delivery of an anorexigenic-associated neurohormone, and the chemoarchitecture of a major feeding-related region, the parabrachial nucleus. First, utilizing 2-deoxy-D-glucose (2-DG) induced glucoprivation, we map the rapid response of dorsal medullary neuronal populations with high spatial …

Understanding Gambling Behavior Among Hispanic College Students: The Role Of Attitudes, Norms, Self-Efficacy, And Acculturation, Joshua Torres

Open Access Theses & Dissertations

Gambling has become increasingly accessible and socially normalized among young adults, particularly through mobile platforms and the expansion of legalized sports betting. Hispanic college students may be at heightened risk for gambling-related harms, given evidence of elevated rates of problem gambling, comorbid mental health concerns, and underrepresentation in empirical research. Cultural factors, such as acculturation, may further influence engagement in gambling behaviors and susceptibility to negative outcomes. Guided by the Theory of Planned Behavior, the present study investigated the relationships between gambling injunctive norms, gambling attitudes, and gambling self-efficacy across three outcomes: gambling frequency, problem gambling severity, and gambling intention. …

Tiny Tusk Internship: Gut Instincts: A Review Of Literature On The Impact Of Breastfeeding On The Infant Gut Microbiome, Rayla Payne

The Eleanor Mann School of Nursing Undergraduate Honors Theses

The purpose of this systematic review was to investigate both the short- and long-term benefits that breastfeeding has on the infant gut microbiome. The PICOT question was: In full-term infants, how does exclusive breastfeeding compared to mixed or formula feeding influence the diversity and composition of the gut microbiome throughout the first 12 months of life? For this research, EBSCOhost, CINAHL, and the National Library of Medicine databases were searched to find relevant studies and systematic reviews. Terms such as “breastfeeding and infant gut microbiome” were used to conduct the search. Other terms used included “breastfeeding OR formula feeding”, “human …

Bridging Care Gaps For Sickle Cell Disease: Examining Case Management And Healthcare Utilization., Lindsey Page

Doctor of Social Work Capstone Projects

Individuals living with sickle cell disease (SCD) experience complex medical and social needs, including high emergency department (ED) utilization, fragmented care, and systemic inequities. Disease-specific case management has emerged as a promising strategy to improve care coordination, patient outcomes, and healthcare efficiency. This mixed-methods case study examined the impact of disease-specific case management on healthcare utilization, patient-reported outcomes, and healthcare providers’ perspectives. Quantitative analysis evaluated the impact of disease-specific case management on ED and inpatient admissions, healthcare-related costs, and the length of stay for inpatient admissions. Qualitative data were collected using interviews with patients and healthcare providers, exploring utilization, bias, …

Parental Monitoring And Approval As Moderators Of Peer And Parental Influences On Adolescent Drinking, Clara Pool

Biological Sciences Undergraduate Honors Theses

Adolescence (i.e., ages 12 to 18) is a developmental period marked by exploration and risk-taking behavior, which is often associated with increased risk for alcohol use. Adolescents’ perceptions of what is typical or approved behavior within their social environments (e.g., peers, parents) may be associated with their drinking behaviors. Parental monitoring is related to reduced substance use risk, though peer and parental influences can interact. For example, adolescents who perceive their parents do not approve of adolescent alcohol use may be less susceptible to alcohol-approving peers. Therefore, this study examined how adolescents’ perceptions of peer approval, parental approval, and parental …

The Emperor Julian As The Lynchpin Of Ammianus Marcellinus’ Histories, Sebastian Peavy

Theses & ETDs

Ammianus Marcellinus prized Julian as his hero in his histories. This paper explores this fact through intratextual analysis. It explores the depiction of the emperors and usurpers Constantius II, Gallus, Valentinian I, Valens, Procopius, Silvanus, and Barbatio through the lens of Julian as the central point of comparison. The paper explores Julian’s own depiction in Ammianus, including his domestic policy, his foreign policy, and the rebellion that elevated him to being emperor. The paper explores domestic and foreign policy for Constantius, Valentinian, Valens, and draws parallels between these elements in their reigns and that of Julian as depicted in Ammianus’ …

Exploring Exercise Motivation And Mental Well-Being In College Students, Elaine M. Lindesmith, Anqi Deng Dr

Health, Human Performance and Recreation Undergraduate Honors Theses

This study examined the relationship between physical activity, exercise motivation, and mental well-being among 48 undergraduate students at the University of Arkansas. Guided by Self-Determination Theory, the study used survey data to measure depression, anxiety, physical activity, and open-ended exercise motivation responses. Motivation responses were coded as autonomous or controlled.

Results showed that physical activity was weakly and negatively related to depression and anxiety, but these relationships were not statistically significant. There were also no significant differences in mental health between autonomous and controlled motivation groups, and motivation did not significantly predict mental health outcomes in regression analyses. Overall, the …

Persistence In The Pressure Cooker: A Mixed-Methods Case Study Of Teacher Working Conditions In High Turnover School Districts, John E. Byrnes

LSU New Orleans Theses and Dissertations

American schools face teacher shortages in many disciplines and age groups (Darling-Hammond et al., 2023; Learning Policy Institute, 2024). Rural and urban schools, especially those serving low-socioeconomic-status students, feel this shortage most (Goldhaber et al., 2021; Ingersoll et al., 2022). Teachers report rising dissatisfaction with their work (Lin et al., 2024). This study examined teacher working conditions in two high-turnover districts: Orleans and Jefferson Parish Schools. It used an explanatory sequential mixed-methods case study to assess working conditions (Creswell & Plano Clark, 2011; Stake, 1995; Yin, 2009). District and federal data showed limited resources in Jefferson Parish. Orleans Parish had …

Mechanisms Of Life History Trade-Offs In The Evolution Of Eusociality, Frances Katherine Hunter

All Graduate Theses and Dissertations, Fall 2023 to Present

When faced with stressors such as pathogen infection, organisms must invest energy in defense or risk death. Because resources are limited, mounting an immune response often comes at the expense of other costly activities such as reproduction. The costs of immunity are shaped by factors including behavior, nutrition, age, and evolutionary history.

Social insects (e.g., ants, bees, and wasps) offer a powerful system for studying these trade-offs because queens in these colonies appear to escape them—living long lives while reproducing prolifically. Bees, which include species that range from those which nest solitarily to those with complex social systems and many …

Exploring The Correlation Between Malnutrition And Food And Nutrition Insecurity In Inflammatory Bowel Disease, Heather Burr

All Graduate Theses and Dissertations, Fall 2023 to Present

Inflammatory Bowel Disease (IBD) may increase the risk of malnutrition because of nausea, vomiting, diarrhea and restrictive eating. In addition, patients with IBD may experience food and nutrition insecurity. Therefore, we conducted an online survey to assess risk of malnutrition and food and nutrition insecurity among adult patients with IBD in outpatient and community settings. Patients were recruited between July and December 2025, aiming to reach adults in the Rocky Mountain Region diagnosed with IBD. Data collected included demographics, health-related factors, risk of nutrition insecurity, risk of food insecurity, and barriers and facilitators to dietary management of IBD.

Fifty-seven patients …

Effect Of Agroecological Feeding Systems Of Dairy Cattle On The Nutritional Composition Of Milk, Sree Bhavya Immadi

All Graduate Theses and Dissertations, Fall 2023 to Present

How food is produced can influence both its nutritional quality and its impact on the environment. In recent years, regenerative (agroecological) farming practices have gained attention for their potential to improve soil health, biodiversity, and the nutritional value of foods. In dairy production, these practices often involve growing more diverse forage crops, reducing soil disturbance, and relying less on monoculture-grown feed rations. However, there is still limited real-world evidence showing how these practices affect the nutritional composition of milk produced on commercial dairy farms.

This dissertation explores how regenerative feeding and feed production practices influence the nutritional quality of milk, …

Developing Transparent Sustainability Data Systems In A Poultry And Pet Food Company: An Internship Case Study, Catherine L. Warren

Biological and Agricultural Engineering Undergraduate Honors Theses

My honors thesis examined my internship experiences and its implications on sustainability data gathering and reporting in poultry and pet food companies. It highlighted my internship projects, the skills I developed, and the connections to sustainability data transparency and reliability in a corporate environment.

In my thesis, I shared details about my internship. I described what projects I worked on, the places I visited, the hands-on experience I gained, and the different teams I worked with throughout the internship duration. I discussed the analytic and professional skills I developed through conducting a waste audit, developing Tableau dashboards, and helping to …

Cross-Facility Reliable Deep Learning Based Beef Marbling Assessment Via Unsupervised Domain Adaptation Regression, Samuel Vinson

Biological and Agricultural Engineering Undergraduate Honors Theses

Inconsistent quality grading in beef production leads to inefficiencies, economic disparity, and consumer mistrust. While USDA meat grading traditionally relies on skilled visual inspectors, these human evaluations suffer from cross-facility variability and subjectivity. This paper introduces the first known application of unsupervised domain adaptation regression for cross-facility beef marbling score prediction—an innovation that improves generalization across diverse environments in the beef supply chain. Utilizing numerical scores ranging from 100-900, the research employed convolutional neural networks (CNNs), including ResNet, VGG, and AlexNet architectures. The study specifically introduced and validated a unified unsupervised domain adaptation regression method using the ResNet-50 architecture to …