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Effects Of Intensive Blood Pressure Treatment On Orthostatic Hypotension : A Systematic Review And Individual Participant-Based Meta-Analysis, Stephen P Juraschek, Jiun-Ruey Hu, Jennifer L Cluett, Anthony Ishak, Carol Mita, Lewis A Lipsitz, Lawrence J Appel, Nigel S Beckett, Ruth L Coleman, William C Cushman, Barry R Davis, Greg Grandits, Rury R Holman, Edgar R Miller, Ruth Peters, Jan A Staessen, Addison A Taylor, Lutgarde Thijs, Jackson T Wright, Kenneth J Mukamal

Faculty, Staff and Students Publications

BACKGROUND: Although intensive blood pressure (BP)-lowering treatment reduces risk for cardiovascular disease, there are concerns that it might cause orthostatic hypotension (OH).

PURPOSE: To examine the effects of intensive BP-lowering treatment on OH in hypertensive adults.

DATA SOURCES: MEDLINE, EMBASE, and Cochrane CENTRAL from inception through 7 October 2019, without language restrictions.

STUDY SELECTION: Randomized trials of BP pharmacologic treatment (more intensive BP goal or active agent) that involved more than 500 adults with hypertension or elevated BP and that were 6 months or longer in duration. Trial comparisons were groups assigned to either less intensive BP goals or placebo, …

Asia Pacific Perspectives Vol. 17 No. 1, 2021, University Of San Francisco

Asia Pacific Perspectives

Contents:

Editor's Introduction by Melissa S. Dale

We are pleased to announce the publication of the latest issue of Asia Pacific Perspectives (vol. 17, no. 1). This issue showcases the resilience and creativity of scholars doing research and writing about the Asia Pacific during the COVID-19 pandemic.

These scholars, like others in the humanities and social sciences, have not only found ways to continue their scholarship during these trying times but to even re-image how to go about doing research moving forward.

From Sanitation to Soybeans: Kitchen Hygiene and Nutritional Nationalism in Republican China, 1911-1945 by Sarah Xia Yu

This …

From Sanitation To Soybeans: Kitchen Hygiene And Nutritional Nationalism In Republican China, 1911–1945, Sarah Xia Yu

Asia Pacific Perspectives

This article investigates evolving expectations for Chinese individuals to clean, cook, eat, and nourish in their private kitchens, and how certain diseases became urgent touchstones for the change in public health priorities. Reformists promoted personal responsibility and popular interest in kitchen and dietary hygiene, which increased as Chinese audiences became exposed to globally- circulating ideas of sanitation and nutrition in individual homes. Furthermore, this occurred in tandem with increased institutionalized government developments for improved infrastructure. This article also highlights Chinese participation in the transnational dietary science movement of the early twentieth century, as reformists developed methods for beriberi and tuberculosis …

The Bile Acid Induced Hepatokine Orosomucoid Suppresses Adipocyte Differentiation, Sung Ho Lee, Jong Min Choi, Sung Yun Jung, Aaron R Cox, Sean M Hartig, David D Moore, Kang Ho Kim

Faculty, Staff and Students Publications

Bile acids have recently emerged as key metabolic hormones with beneficial impacts in multiple metabolic diseases. We previously discovered that hepatic bile acid overload distally modulates glucose and fatty acid metabolism in adipose tissues to exert anti-obesity effects. However, the detailed mechanisms that explain the salutary effects of serum bile acid elevation remain unclear. Here, proteomic profiling identified a new hepatokine, Orosomucoid (ORM) that governs liver-adipose tissue crosstalk. Hepatic ORMs were highly induced by both genetic and dietary bile acid overload. To address the direct metabolic effects of ORM, purified ORM proteins were administered during adipogenic differentiation of 3T3-L1 cells …

Women Have A Lower Risk Of Nonalcoholic Fatty Liver Disease But A Higher Risk Of Progression Vs Men: A Systematic Review And Meta-Analysis, Maya Balakrishnan, Parth Patel, Sydney Dunn-Valadez, Cecilia Dao, Vinshi Khan, Hiba Ali, Laith El-Serag, Ruben Hernaez, Amy Sisson, Aaron P Thrift, Yan Liu, Hashem B El-Serag, Fasiha Kanwal

Library Staff Publications

BACKGROUND & AIMS: The risk of nonalcoholic fatty liver disease (NAFLD) and its progression may differ between men and women. We conducted a systematic review and meta-analysis to determine the relationship between sex and NAFLD, nonalcoholic steatohepatitis (NASH), and advanced NAFLD fibrosis.

METHODS: Studies reporting sex-stratified NAFLD prevalence among population-based samples and either NASH or advanced fibrosis among patients with biopsy-proven NAFLD were identified from MEDLINE, EMBASE, and Cochrane databases through December 2017. We calculated pooled relative risk ratios comparing women vs men for each outcome.

RESULTS: Our final analysis comprised 54 studies. Samples sizes were 62,239 for the NAFLD …

Pet Rabbit Projects: Getting Started, Melanie Stock, Jessie Hadfield, Jake Hadfield, Nicloe Reed

All Current Publications

Rabbits are becoming increasingly popular companion animals. Pet rabbits can thrive in rural and suburban environments and can happily live indoors or outside. They are relatively low maintenance compared to some of the more common family pets and are great for all ages of youth with proper supervision and education. It is important not to be fooled into thinking they are an easy pet, however. Rabbits are a long-term commitment that require daily care and continued effort. This fact sheet has tips to get started keeping rabbits as pets.

The Coaches’ Eye: Exploring Coach Decision-Making During Talent Identification, Alexandra Hannah Roberts

Theses: Doctorates and Masters

For decades, researchers and practitioners interested in talent identification have discussed the coaches’ eye: the elusive ability that allows some coaches to ‘see’ qualities in an athlete that point to their talent or future potential. While there is significant anecdotal evidence of coaches who possess this ability, there is little empirical research supporting the validity or reliability of the coaches’ eye. Guided by ecological dynamics, this thesis employs mixed methodologies to explore the decision-making that underpins how high-level coaches identify talent in Olympic combat sports. These four studies captured the processes of thirty- four coaches during the talent identification process, …

Veterans Health Administration's Whole Health System Of Care: Supporting The Health, Well-Being, And Resiliency Of Employees, Kavitha P Reddy, Tamara M Schult, Alison M Whitehead, Barbara G Bokhour

2020-Current year OA Pubs

The Veterans Health Administration (VHA) is implementing a Whole Health System (WHS) of care that empowers and equips Veterans to take charge of their health and well-being and live their lives to the fullest, and increasingly leaders recognize the need and value in implementing a similar approach to support the health and well-being of employees. The purpose of this paper is to do the following: 1) provide an overview of the WHS of care in VHA and applicability in addressing employee resiliency; 2) provide a brief history of employee well-being efforts in VHA to date; 3) share new priorities from …

Nurse Practitioners’ Experiences Working With Patients Living With Morbid Obesity, Sharon A. Mclimans

Open Access Dissertations

Morbid obesity is recognized as a complex chronic medical disease which has been increasing at an alarming rate in the U.S. The etiologies of this disease involve a complex interplay of genetics, physiological, psychological, behavioral, socioeconomic, and environmental factors. Serious medical consequences are associated with morbid obesity including diabetes, hyperlipidemia, hypertension, cardiovascular disease, and increasing the risk of certain cancers. Research has shown individuals with morbid obesity have higher incidence of depression and are subjected to stigmatizing and biases across society including health care professionals. The monumental cost of health care associated with morbid obesity places enormous burden on our …

Phytoplankton Thermal Responses As Drivers Of Community Composition And Biogeography In A Changing Environment, Stephanie I. Anderson

Open Access Dissertations

Phytoplankton are biogeochemically relevant, sequestering 45 Gt of carbon each year, roughly equivalent to all terrestrial plants combined. Because of their ecological importance to marine ecosystems and the biosphere, many have sought to assess the factors that regulate phytoplankton communities and make projections for how they may fare in a future ocean. This endeavor has proven challenging as phytoplankton are incredibly diverse, with varied and unique evolutionary histories. To confront this complexity, phytoplankton are often distilled down to a few key physiological traits which have been mathematically characterized. In this simplification, insights regarding broad ecological trends can be discerned with …

Carrot Or Stick: Nudging Consumers Towards Healthier Choices Through Customized Price Incentives, Xintong Guan

Open Access Dissertations

In a market where consumers are increasingly concerned with maintaining a healthy diet and demand healthier foods, the role of retail grocery stores has been highlighted, as they exert a powerful influence on food choices. To increase more healthful food purchases, some food retailers have implemented marketing efforts to influence consumer food decision-making. However, due to the mixed findings on the effect of existing marketing interventions on improving purchasing of healthier foods, it is unclear which interventions work best to shift purchasing and what benefits they can bring to the retailer.

A promising approach to nudge healthy purchases with behavioral …

Predictors Of Paired, Singular, And No Action Among Middle School Students With Behavior Risks, Eva-Molly Petitto Dunbar

Open Access Dissertations

Understanding multiple health risk behavior change may contribute to the prevention of chronic illness. The present study examined drivers of behavior change over time within individuals with health behavior risks who were at risk for two behaviors. Participants were middle school students from a randomized controlled trial conducted across 20 middle schools within the state of Rhode Island using two transtheoretical model tailored, computer-delivered interventions in the school setting. Participants received an alcohol prevention program or an energy balance program. Analyses were conducted with participants who were at risk for both physical activity and fruit and vegetable intake (N = …

Re- Imagining Agenda 2063: A Socio-Legal Foundation Of The Africa We Want, Sara Ghebremusse, Toby S. Goldbach, Oludolapo Makinde

All Faculty Publications

Re- Imagining Agenda 2063: A Socio-Legal Foundation of the Africa We Want, June 21 - 24, 2021 Virtual Conference Report

Improving Microbial Safety Of Food Products By Thermal And Non-Thermal Technology And Evaluate The Knowledge Of Antibiotic Resistant Issue Among Local Produce Growers, Wentao Jiang

Graduate Theses, Dissertations, and Problem Reports (ETD)

Microbial contamination of food products is one of the main transmission routes of disease in the world today, which is responsible for about two-thirds of all food-borne disease outbreaks although the hygiene process was improved recently. Improving microbial safety and implementing a good food management system are important elements to reduce microbial contamination and improve food safety and security. To improve microbial safety, I conducted inactivation studies on food pathogens and further explored antibiotic resistant risks. Initial research evaluated the efficacy of commercial antimicrobials distribution by comparing electrostatic sprayer with conventional sanitization process. The antibiotics applied by electrostatic spraying achieved …

A Role For Endothelial Tissue-Nonspecific Alkaline Phosphatase In Blood-Tissue Barrier Health And Disease, Allison L. Brichacek

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sepsis is a disorder that targets the microcirculation with significant effects at blood-tissue barriers such as the blood-brain barrier (BBB) and gut-vascular barrier (GVB). Intestinal barrier dysfunction is thought to be one of the most important contributors to multi-organ dysfunction in sepsis. As a common site of infection, the impaired gut allows the dissemination of bacteria, which exacerbates the disease pathophysiology, and can lead to long-term morbidity and mortality. The mechanisms that influence altered barrier permeability in the GVB in sepsis and other inflammatory disorders are not well understood. Tissue-nonspecific alkaline phosphatase (TNAP) enzyme activity, which has been shown to …

Response Of Forest Birds To Spotted Wing Drosophila (Drosophila Suzukii Matsumura), A Novel Invasive Fruit Pest, At Allegheny National Forest, Daniel P. Roche

Graduate Theses, Dissertations, and Problem Reports (ETD)

Non-native invasive insect pests can have dramatic impacts on native ecosystems, feeding on plant foliage, wood, or sap. Little is known, however, about how fruit-targeting NNIIPs may affect native ecosystems. Spotted wing Drosophila (Drosophila suzukii Matsumura, SWD) is a recently introduced invasive vinegar fly that parasitizes the fruits of many plant species in the United States. While its activity in agricultural systems is well-documented, little is known about its activity in forest ecosystems, despite growing evidence of its presence and parasitism of fruits there. Parasitism could reduce fruit attractiveness for vertebrate fruit consumers, including migratory birds. As such, this …

Hands And Health: Quantifying Occupational Exposures And Implications Of Disability, Sueann R. Woods

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: Hand grip strength (HGS) has been negatively correlated with both biologic, cognitive, and mental health markers. Aim one investigated how occupational metabolic equivalents (OMETs), impacted HGS. Aim two investigated lost time from work and the association with HGS. Finally, aim three investigated the health outcomes of workers’ compensation claimants who have lost time from work, following diagnosis of CTS.

Results:HGS was positively associated with OMET (rs = 0.078, p = 0.009). Linear regression model demonstrated a statistically significant association between HGS and OMETs, F(1, 31) = 9.735, p = .001. Aim two found that all occupation groups had …

Unconventional Gas Pipeline Right-Of-Way Influence On Wildlife, Samuel C. Knopka

Graduate Theses, Dissertations, and Problem Reports (ETD)

The development of horizontal drilling for natural gas in the Marcellus Shale in 2004 resulted in rapid exploitation of the play in the Appalachian Basin. This “unconventional” gas well drilling accesses resources deeper beneath the surface and allows for multiple wells to be co-located on a single well pad. This results in fewer, but larger, well pads on the landscape than traditional vertical wells. Pipelines are required to transport the volumes of gas produced by unconventional wells to production facilities and market. The effects of gathering pipelines, which transport gas from well pads to larger transport pipelines, are poorly studied …

A Survey Of Anthelmintic Resistance In Angus Bulls Participating In Centralized Performance Tests In Appalachia, Roger Tyler Rohrbaugh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Resistance to anthelmintics, more commonly referred to as “de-wormers,” has been on the rise in parasites that affect cattle. Parasite infection can have severe impacts on calf productivity resulting in reduced profitability. Therefore, we sought to better understand anthelmintic resistance in Appalachia by surveying Angus bulls entering performance tests in VA and WV. During a four-year period, over 1050 Angus bulls were tested at bull development facilities in Wardensville, WV, Culpeper, VA and Wytheville, VA. Fecal samples were collected at arrival and 14-21 days later for determination of fecal egg count (FEC) reduction. Upon arrival, all bulls received either fenbendazole …

Effect Of Diet, Age, And Genetics On Rainbow Trout Growth And Fillet Quality, Bahareh Adami

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this study, analyses were conducted to compare fillet quality attributes of 4 rainbow trout families (40, 102, 159, and 187) fed fish meal (FM) and a fishmeal free diet (FMF), to two age endpoints, 9 and 11 months.

Previous studies with rainbow trout have evaluated the effect of age, diet, and family on growth performance and fillet quality. However, a comprehensive analysis of variables is lacking for rainbow trout, one of the main aquatic foods for domestic and international consumers.

Separable muscle as a percent whole body weight was not affected by diet, family, age, and the interaction of …

Exploring The Perceptions Of Produce Processors Operating In Non-Profit Commercial Kitchens In West Virginia, Megan Christine Govindan

Graduate Theses, Dissertations, and Problem Reports (ETD)

According to the Centers for Disease Control and Prevention, 48 million people get sick, 128,000 are hospitalized and 3,000 die each year from foodborne illness. The Food Safety Modernization Act (FSMA) shifted the focus of the Food and Drug Administration from response, to prevention of foodborne illness. The FSMA identified seven rules related to food safety prevention measures, including inspection and compliance, response and enhanced partnerships to ensure food safety along the food system, and employee-training compliance measures. Increasing access to healthy, local foods has economic, public health, and environmental benefits. Farm to Institution policies are becoming more popular nationally, …

Initial And Advanced Stages Of Microbiota Establishment Within The Tsetse Fly, Miguel Eduardo Medina Munoz

Graduate Theses, Dissertations, and Problem Reports (ETD)

Symbiosis is a long-term physical association between two or more species, although little is known regarding its evolutionary origins, particularly at the genetic level. Tsetse flies are the vector of African trypanosomes, causative agents of Human and Animal African Trypanosomiases. Tsetse provide an ideal model for studying initial and advanced stages of symbiosis. Tsetse have a simple digestive tract microbiota primarily consisting of two bacteria; the ancient mutualist Wigglesworthia glossinidia and the recently acquired Sodalis glossinidius. This work presents a chronological study in evolutionary terms of the history of a microbial-insect association. First, I present concepts on symbiosis and …

Intellectual Property As A Determinant Of Health, Ana Santos Rutschman

All Faculty Scholarship

Public health literature has long recognized the existence of determinants of health, a set of socio-economic conditions that affect health risks and health outcomes across the world. The World Health Organization defines these determinants as “forces and systems” consisting of “factors combin[ing] together to affect the health of individuals and communities.” Frameworks relying on determinants of health have been widely adopted by countries in the global South and North alike, as well as international institutional players, several of which are direct or indirect players in transnational intellectual property (IP) policymaking. Issues raised by the implementation of IP policies, however, are …

Effect Of Fecal Egg Count Estimated Breeding Value On Antibody Production In Katahdin Lambs, Kelsey L. Bentley

Graduate Theses, Dissertations, and Problem Reports (ETD)

With current pressures to seek out genetic solutions to combat antimicrobial resistance, genetic resistance to the gastrointestinal nematode Haemonchus contortus may reduce need for prophylactic antibiotic use. The Katahdin breed has effectively utilized post-weaning fecal egg count estimated breeding value (PFEC EBV) to reduce parasitism within their flocks, but there still remains significant opportunity for selection within breed. In a previous study, Katahdin sheep sired by low PFEC sires had greater survivability to weaning than lambs sired by high PFEC rams and preweaning was caused by other diseases than parasitism. Those data lead to the hypothesis that selection for PFEC …

The Effects Of Genetic Differences In An Innate Immune Receptor On Immune Responses To Haemonchus Contortus In Sheep, Denzel Deshawn Middleton

Graduate Theses, Dissertations, and Problem Reports (ETD)

Little is known about differences observed in early immunological signaling events that result in cellular infiltration and Th2 cytokine production that mediate parasite expulsion. Parasite resistant St. Croix (STC) sheep have been used as model for full host protective immunity as they present the ability to respond to larval stages of H. contortus. RNA sequencing analysis of peripheral blood mononuclear cells (PBMC) stimulated with H. contortus larval antigen (HcLA) revealed significant upregulation in NLRP3 and its pathway component TLR4. Predicted protein structural software identified distinct differences in NLRP3 protein structure in STC and parasite susceptible Suffolk (SUF) sheep. NLRP3 …

Decision-Making Involvement, Social Support For Healthy Behaviors, And Nutritional Adherence In Adolescents With Cystic Fibrosis, Jennifer Kelleher

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Adolescents with cystic fibrosis (awCF) exhibit suboptimal adherence to dietary and enzyme recommendations despite the fact that eating a high calorie diet with enzymes significantly improves lung functioning. Furthermore, during adolescence teens and their caregivers begin to negotiate treatment responsibility, shifting treatment tasks to the youth. As such, it is important to understand which aspects of the complex decision-making process (e.g., expressing an opinion, asking for information from parents/adults, making joint decisions with parents) relate to better dietary adherence in adolescents with CF and how parents can best support these healthy behaviors. Thus, this study aimed to identify how …

Annual Report, Fiscal Year 2021, Tennessee. Department Of Correction

Annual Reports

This document is the annual report for the Tennessee Department of Correction during the fiscal year.

Should Human Rights Practice Be Rights-Based?, Sarah Knuckey, Margaret Satterthwaite

Faculty Scholarship

Human rights scholars and organizations often call on governments to adopt ‘human rights-based approaches’ (HRBAs) to many policy areas, from climate change to health policy. HRBAs identify rights and obligations, and advance the principles of participation, accountability, equality, and non-discrimination. This chapter argues that HRBAs have been exported to many fields without ever being sufficiently integrated within human rights advocacy. We find that NGOs often fail to adhere to foundational human rights principles in their own work, reproducing unjust power hierarchies, objectifying victims, and disempowering rights-holders. Were HRBAs adopted by more human rights organizations, the face of human rights advocacy …

Pandemic Schooling And The Politics Of Safety, Lisa M. Kelly, Deniz Kilinc, Sonia Lawrence, Cosimo Morin

Articles & Book Chapters

In this paper, the authors consider how pandemic schooling is increasing educational inequalities that may have generational effects. Reviewing emerging evidence on rates of return to in-person schooling and disparities in remote learning in Ontario, the authors argue that the pandemic is accelerating existing trends of privatization and choice. Emerging data suggests that students from more affluent and whiter households have returned to in-person learning at higher rates than their lower-income and racialized peers. When families with more resources have opted for remote learning, they have been better able to supplement online lessons. For numerous reasons, including higher rates of …

Microbiome Metadata Standards: Report Of The National Microbiome Data Collaborative's Workshop And Follow-On Activities, Pajau Vangay, Josephine Burgin, Anjanette Johnston, Kristen L. Beck, Daniel C. Berrios, Kai Blumberg, Shane Canon, Patrick Chain, John-Marc Chandonia, Danielle Christianson, Sylvain V. Costes, Joan Damerow, William D. Duncan, Jose Pablo Dundore-Arias, Kjiersten Fagnan, Jonathan M. Galazka, Sean M. Gibbons, David Hays, Judson Hervey, Bin Hu, Bonnie L. Hurwitz, Pankaj Jaiswal, Marcin P. Joachimiak, Linda Kinkel, Joshua Ladau, Stanton L. Martin, Lee Ann Mccue, Kayd Miller, Nigel Mouncey, Chris Mungall, Evangelos Pafilis, T B. Reddy, Lorna Richardson

Biology, Agriculture and Chemistry Faculty Publications and Presentations

Microbiome samples are inherently defined by the environment in which they are found. Therefore, data that provide context and enable interpretation of measurements produced from biological samples, often referred to as metadata, are critical. Important contributions have been made in the development of community-driven metadata standards; however, these standards have not been uniformly embraced by the microbiome research community. To understand how these standards are being adopted, or the barriers to adoption, across research domains, institutions, and funding agencies, the National Microbiome Data Collaborative (NMDC) hosted a workshop in October 2019. This report provides a summary of discussions that took …