Digital Commons Network^™

Intellectual Property As A Determinant Of Health, Ana Santos Rutschman

All Faculty Scholarship

Public health literature has long recognized the existence of determinants of health, a set of socio-economic conditions that affect health risks and health outcomes across the world. The World Health Organization defines these determinants as “forces and systems” consisting of “factors combin[ing] together to affect the health of individuals and communities.” Frameworks relying on determinants of health have been widely adopted by countries in the global South and North alike, as well as international institutional players, several of which are direct or indirect players in transnational intellectual property (IP) policymaking. Issues raised by the implementation of IP policies, however, are …

Effect Of Fecal Egg Count Estimated Breeding Value On Antibody Production In Katahdin Lambs, Kelsey L. Bentley

Graduate Theses, Dissertations, and Problem Reports (ETD)

With current pressures to seek out genetic solutions to combat antimicrobial resistance, genetic resistance to the gastrointestinal nematode Haemonchus contortus may reduce need for prophylactic antibiotic use. The Katahdin breed has effectively utilized post-weaning fecal egg count estimated breeding value (PFEC EBV) to reduce parasitism within their flocks, but there still remains significant opportunity for selection within breed. In a previous study, Katahdin sheep sired by low PFEC sires had greater survivability to weaning than lambs sired by high PFEC rams and preweaning was caused by other diseases than parasitism. Those data lead to the hypothesis that selection for PFEC …

The Effects Of Genetic Differences In An Innate Immune Receptor On Immune Responses To Haemonchus Contortus In Sheep, Denzel Deshawn Middleton

Graduate Theses, Dissertations, and Problem Reports (ETD)

Little is known about differences observed in early immunological signaling events that result in cellular infiltration and Th2 cytokine production that mediate parasite expulsion. Parasite resistant St. Croix (STC) sheep have been used as model for full host protective immunity as they present the ability to respond to larval stages of H. contortus. RNA sequencing analysis of peripheral blood mononuclear cells (PBMC) stimulated with H. contortus larval antigen (HcLA) revealed significant upregulation in NLRP3 and its pathway component TLR4. Predicted protein structural software identified distinct differences in NLRP3 protein structure in STC and parasite susceptible Suffolk (SUF) sheep. NLRP3 …

Decision-Making Involvement, Social Support For Healthy Behaviors, And Nutritional Adherence In Adolescents With Cystic Fibrosis, Jennifer Kelleher

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Adolescents with cystic fibrosis (awCF) exhibit suboptimal adherence to dietary and enzyme recommendations despite the fact that eating a high calorie diet with enzymes significantly improves lung functioning. Furthermore, during adolescence teens and their caregivers begin to negotiate treatment responsibility, shifting treatment tasks to the youth. As such, it is important to understand which aspects of the complex decision-making process (e.g., expressing an opinion, asking for information from parents/adults, making joint decisions with parents) relate to better dietary adherence in adolescents with CF and how parents can best support these healthy behaviors. Thus, this study aimed to identify how …

Annual Report, Fiscal Year 2021, Tennessee. Department Of Correction

Annual Reports

This document is the annual report for the Tennessee Department of Correction during the fiscal year.

Should Human Rights Practice Be Rights-Based?, Sarah Knuckey, Margaret Satterthwaite

Faculty Scholarship

Human rights scholars and organizations often call on governments to adopt ‘human rights-based approaches’ (HRBAs) to many policy areas, from climate change to health policy. HRBAs identify rights and obligations, and advance the principles of participation, accountability, equality, and non-discrimination. This chapter argues that HRBAs have been exported to many fields without ever being sufficiently integrated within human rights advocacy. We find that NGOs often fail to adhere to foundational human rights principles in their own work, reproducing unjust power hierarchies, objectifying victims, and disempowering rights-holders. Were HRBAs adopted by more human rights organizations, the face of human rights advocacy …

Pandemic Schooling And The Politics Of Safety, Lisa M. Kelly, Deniz Kilinc, Sonia Lawrence, Cosimo Morin

Articles & Book Chapters

In this paper, the authors consider how pandemic schooling is increasing educational inequalities that may have generational effects. Reviewing emerging evidence on rates of return to in-person schooling and disparities in remote learning in Ontario, the authors argue that the pandemic is accelerating existing trends of privatization and choice. Emerging data suggests that students from more affluent and whiter households have returned to in-person learning at higher rates than their lower-income and racialized peers. When families with more resources have opted for remote learning, they have been better able to supplement online lessons. For numerous reasons, including higher rates of …

Microbiome Metadata Standards: Report Of The National Microbiome Data Collaborative's Workshop And Follow-On Activities, Pajau Vangay, Josephine Burgin, Anjanette Johnston, Kristen L. Beck, Daniel C. Berrios, Kai Blumberg, Shane Canon, Patrick Chain, John-Marc Chandonia, Danielle Christianson, Sylvain V. Costes, Joan Damerow, William D. Duncan, Jose Pablo Dundore-Arias, Kjiersten Fagnan, Jonathan M. Galazka, Sean M. Gibbons, David Hays, Judson Hervey, Bin Hu, Bonnie L. Hurwitz, Pankaj Jaiswal, Marcin P. Joachimiak, Linda Kinkel, Joshua Ladau, Stanton L. Martin, Lee Ann Mccue, Kayd Miller, Nigel Mouncey, Chris Mungall, Evangelos Pafilis, T B. Reddy, Lorna Richardson

Biology, Agriculture and Chemistry Faculty Publications and Presentations

Microbiome samples are inherently defined by the environment in which they are found. Therefore, data that provide context and enable interpretation of measurements produced from biological samples, often referred to as metadata, are critical. Important contributions have been made in the development of community-driven metadata standards; however, these standards have not been uniformly embraced by the microbiome research community. To understand how these standards are being adopted, or the barriers to adoption, across research domains, institutions, and funding agencies, the National Microbiome Data Collaborative (NMDC) hosted a workshop in October 2019. This report provides a summary of discussions that took …

Weak Olfactory Preferences Of The Gall Midge Asphondylia Borrichiae, Associated Fungal Endophytes And Implications On Gene Flow And Host Range Expansion, Frances S. Nagle

UNF Graduate Theses and Dissertations

Asphondylia borrichaie is a small fly (Diptera: Cecidomyiidae) that is currently undergoing host-associated sympatric divergence. Asphondylia borrichaie is an ambrosia galler, these insects utilize a host plant for oviposition, but its offspring also rely on a symbiotic fungus (or fungal community) to promote the formation of the gall as well as serve as a food source for the developing larvae. Previous studies indicate that A. borrichaie consists of two host- associated populations based on its original host plant Borrichia frutescens (Asterales: Asteraceae), and another one from the two Iva species (I. frutescens (Asterales: Asteraceae) and I. imbricata …

Surgical Management Of Complex Post-Tuberculous Kyphosis Among African Patients: Clinical And Radiographic Outcomes For A Consecutive Series Treated At A Single Institution In West Africa, Ali M. Maziad, Owoicho Adogwa, Henry Ofori Duah, Kawdwo P. Yankey, Derrick Nyantakyi Owusu, Arthur Sackeyfio, Mabel Adobea Owiredu, Tyler Wilps, Gerhard Ofori-Amankwah, Franklin Coleman, Harry Akoto, Irene Wulff, Oheneba Boachie-Adjei, Focos Spine Research Group

College of Nursing Faculty Research and Publications

Study design Retrospective review of consecutive series. Objective To assess the clinical and radiographic outcomes after surgical management of post-tuberculous kyphosis. Summary of background data Post-tuberculous (TB) kyphosis can lead to progressive pulmonary and neurological deterioration. Surgery is indicated to decompress neural elements and correct the spine deformity. Although posterior vertebral column resection (PVCR) has been established as the treatment of choice for severe TB kyphosis, there is paucity of studies on the clinical outcomes among patients treated in West Africa. Methods Clinical and radiographic data of 57 patients (pts) who underwent surgical correction of post-TB kyphosis at a single …

Distributional Arguments, In Reverse, Alex Raskolnikov

Faculty Scholarship

This Article contends that the government should consider – rather than ignore – distributional consequences both in the design of legal rules and during legal transitions. This does not mean that the distributional effect of every legal rule should be measured and taken into account in the rule’s design. But if the likely distributional effects are unintended, large, and objectionable, if the efficiency of the legal rule is doubtful, if the compensating tax-and-transfer adjustment is not forthcoming (or has not occurred), policymakers should take distribution into account. One way of doing so is to choose among several alternative legal rules …

Preemption: The Continuing Challenge, Richard Briffault

Faculty Scholarship

The decade of the 2010s witnessed the emergence and rapid spread of aggressive state preemption of local government actions. This “new preemption” consists of intentional, extensive, and sometimes punitive state efforts to block local action across a wide range of domains—from firearms regulation to the treatment of immigrants, workplace equity to environmental protection, the scope of anti-discrimination laws to the regulation of the sharing economy. This new preemption has roots going back to the turn of this century, and began to build decades ago, but it took off most dramatically after the Republican takeover of many state governments in 2010, …

American Exceptionalism At Its Finest: “Soft On Crime” Now A Vote-Winner In The World’S Largest Incarcerator, Mirko Bagaric, Gabrielle Wolf, Daniel Mccord, Brienna Bagaric, Nick Fischer

Lewis & Clark Law Review

Anyone with even a remote interest in criminal justice was stunned by the “soft on crime” Republican Party advertisement at Super Bowl LIV in 2020, especially during a presidential election year. The United States of America has pursued an unrelenting, merciless “tough on crime” approach for half a century, resulting in it being the world’s largest incarcerator by a massive margin. It was an unshakable political ideology that “tough on crime” was a vote winner. This resulted in incarceration levels increasing fourfold in four decades, with more than two million Americans ultimately behind bars. Legal and criminology scholars had argued …

Tick Ecdysteroid Hormone, Global Microbiota/Rickettsia Signaling In The Ovary Versus Carcass During Vitellogenesis In Part-Fed (Virgin) American Dog Ticks, Dermacentor Variabilis, Loganathan Ponnusamy, Haley Sutton, Robert D. Mitchell Iii, Daniel E. Sonenshine, Charles S. Apperson, Richard Michael Roe

Biological Sciences Faculty Publications

The transovarial transmission of tick-borne bacterial pathogens is an important mechanism for their maintenance in natural populations and transmission, causing disease in humans and animals. The mechanism for this transmission and the possible role of tick hormones facilitating this process have never been studied. Injections of physiological levels of the tick hormone, 20-hydroxyecdysone (20E), into part-fed (virgin) adult females of the American dog tick, Dermacentor variabilis, attached to the host caused a reduction in density of Rickettsia montanensis in the carcass and an increase in the ovaries compared to buffer-injected controls. This injection initiates yolk protein synthesis and uptake …

Comparison Of Growth Performance And Meat Quality Traits Of Commercial Cross-Bred Pigs Versus The Large Black Pig Breed, Yongjie Wang, Keshari Thakali, Palika Morse, Sarah Shelby, Jinglong Chen, Jason Apple, Yan Huang

Animal Science Faculty Publications and Presentations

The meat quality of different pig breeds is associated with their different muscle tissue physiological processes, which involves a large variety of genes related with muscle fat and energy metabolism. Understanding the differences of biological processes of muscle after slaughter is helpful to reveal the meat quality development of different breeds. Therefore, eight native Large Black pigs (BP), with high fat content in meat, and seven cross-bred commercial pigs (CP), which had a high feed efficiency with high lean meat, were used to investigate the differences in their meat quality and RNA transcriptomes. The average daily gain (ADG) and hot …

Radical Response: Effects Of Heat Stress-Induced Oxidative Stress On Lipid Metabolism In The Avian Liver, Nima K. Emami, Usuk Jung, Brynn Voy, Sami Dridi

Poultry Science Faculty Publications and Presentations

Lipid metabolism in avian species places unique demands on the liver in comparison to most mammals. The avian liver synthesizes the vast majority of fatty acids that provide energy and support cell membrane synthesis throughout the bird. Egg production intensifies demands to the liver as hepatic lipids are needed to create the yolk. The enzymatic reactions that underlie de novo lipogenesis are energetically demanding and require a precise balance of vitamins and cofactors to proceed efficiently. External stressors such as overnutrition or nutrient deficiency can disrupt this balance and compromise the liver’s ability to support metabolic needs. Heat stress is …

Evaluability Assessment: Mary Free Bed Sub-Acute Rehab, Andrew Jakubik

SPNHA Review

Program evaluation is a field of study that is used to find opportunities for improvement to improve the public value of the program (Newcomer et al, 2015). However, to determine if an organization or program can truly benefit from an evaluation and generate action from the results the organization or program can undergo an evaluability assessment, which looks at aspects such as culture or systems in place. This research paper conducts an evaluability assessment for Mary Free Bed Rehabilitation Hospital to determine how receptive its Sub-Acute Rehabilitation unit would be to an evaluation, followed by recommendations that are supported by …

Chapter 15: Family Caregiving, Anna Hammersmith

Books and Contributions to Books

The United States’ aging population has led to a greater need for caregivers. This responsibility often falls to family members. Social workers can support family caregivers, but mindfulness about group and individual differences is crucial. Understanding diverse needs of family caregivers and recipients will help social workers effectively implement interventions.

Chapter 1: Introduction: Toward A New Era Of Human Rights, Lihua Huang

Books and Contributions to Books

Using the human rights approach, this chapter attempts to fundamentally understand more diverse, healthy, active, and unequal older Americans. It explores genesis of ageism and calls professionals to recognize and combat pervasive ageism in their own attitudes, emotion, beliefs, and behaviors as in the society and professional practice.

Factors Influencing Student Enrollment In Career Academy Programs, Whitney Ketchledge, Michael Kosloski, Philip Reed

Educational Leadership & Workforce Development Faculty Publications

There is considerable research demonstrating strong benefits of the career academy model to students and teachers, but there is little indicating why students enroll in academies and what methods of recruitment may work best. This study assessed factors influencing students' decisions to enroll in career academy programs by looking at factors that influence students to apply for academy programs and reasons students have for choosing not to enroll in academy programs. A survey was used to collect the necessary data with n = 401 responses from students enrolled in an academy and n = 2,421 responses from students not enrolled …

N2 Year In Review, Josep Dalmau, Marinos Dalakas, Dennis L Kolson, Friedemann Paul, Scott S Zamvil

Department of Neurology Faculty Papers

No abstract provided.

Reconstruction Of Ancient Microbial Genomes From The Human Gut, M. C. Wibowo, Z. Yang, M. Borry, A. Hubner, K. D. Huang, B. T. Tierney, S. Zimmerman, F. Barajas-Olmos, C. Contreras-Cubas, H. Garcia-Ortiz, A. Martinez-Hernandez, J. M. Luber, K. Reinhard Et Al.

School of Natural Resources: Faculty Publications

No abstract provided.

J Mich Dent Assoc January 2021

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

• A cover story on “The Dentist’s Role in Recognizing Sleep-Disordered Breathing in Children”.
• A feature article, “Dental Sleep Medicine Education: Do You Want a Nap or a Full Night’s Sleep?”.
• The feature article, “In-office Plans: Where Are We Now? What Have We Learned?”
• News you need, Editorial and regular department articles on MDA Foundation activities, …

Involvement In Community Service And Spiritual Activities As Correlates Of Socially Responsible Leadership Among Undergraduate Students At Asia-Pacific International University, Thailand, Naltan Lampadan

Dissertations

Problem

Institutions of Higher Education invest considerable resources to provide students with leadership experiences through extracurricular activities, especially in community service and spiritual programming. The inter-relationship among these variables (socially responsible leadership, spiritual and community involvement) have not been investigated in faith-based institutions of higher education in Southeast Asia.

Purpose of the Study

This study had four purposes: (a) to examine the extent of student involvement in community service and spiritual activities; (b) to investigate the level of socially responsible leadership among undergraduate students; (c) to examine whether socially responsible leadership might be related to gender, nationality, class status, and …

The E3 Ligase Traf4 Promotes Igf Signaling By Mediating Atypical Ubiquitination Of Irs-1, Wenjuan Yu, Ramesh Singh, Zhao Wang, Bert W O'Malley, Ping Yi

Faculty, Staff and Students Publications

Insulin-like growth factor (IGF) is a potent mitogen that activates the IGF receptor (IGFR)/insulin receptor substrate (IRS) axis, thus stimulating growth in normal cells and uncontrolled cell proliferation in cancer. Posttranslational modifications of IRS such as ubiquitination tightly control IGF signaling, and we previously identified IRS-1 as a potential substrate for the E3 ubiquitin ligase TRAF4 using an unbiased screen. Here we provide evidence that TRAF4-mediated ubiquitination of IRS-1 is physiologically relevant and crucial for IGF signal transduction. Through site-directed mutagenesis we found that TRAF4 promotes an atypical K29-linked ubiquitination at the C-terminal end of IRS-1. Its depletion abolishes AKT …

Long Noncoding Rnas And Their Therapeutic Promise In Diabetic Nephropathy, Juan D Coellar, Jianyin Long, Farhad R Danesh

Faculty, Staff and Students Publications

Recent advances in large-scale RNA sequencing and genome-wide profiling projects have unraveled a heterogeneous group of RNAs, collectively known as long noncoding RNAs (lncRNAs), which play central roles in many diverse biological processes. Importantly, an association between aberrant expression of lncRNAs and diverse human pathologies has been reported, including in a variety of kidney diseases. These observations have raised the possibility that lncRNAs may represent unexploited potential therapeutic targets for kidney diseases. Several important questions regarding the functionality of lncRNAs and their impact in kidney diseases, however, remain to be carefully addressed. Here, we provide an overview of the main …

Mitochondrial Regulation Of Diabetic Kidney Disease, Daniel L Galvan, Koki Mise, Farhad R Danesh

Faculty, Staff and Students Publications

The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are poorly understood. Diabetic kidney cells exhibit a cascade of mitochondrial dysfunction ranging from changes in mitochondrial morphology to significant alterations in mitochondrial biogenesis, biosynthetic, bioenergetics and production of reactive oxygen species (ROS). How these changes individually or in aggregate contribute to progression of DKD remain to be fully elucidated. Nevertheless, because of the remarkable progress in our basic understanding of the role of mitochondrial biology and its dysfunction in DKD, there is great excitement …

Malnutrition In Orthopaedic Sports Medicine: A Review Of The Current Literature, Jihoon T Choi, Brandon Yoshida, Omid Jalali, George F Hatch

Faculty, Staff and Students Publications

CONTEXT: Malnutrition is well-studied in various aspects of the orthopaedic literature, most commonly in relation to arthroplasty, spine surgery, and trauma. However, the management of nutritional deficiencies is commonly overlooked among orthopaedic sports medicine providers. The purpose of this article is to analyze the available sports medicine literature to review the associations between malnutrition and the management of orthopaedic sports medicine patients from a treatment and performance standpoint.

EVIDENCE ACQUISITION: PubMed was searched for relevant articles published from 1979 to 2019.

STUDY DESIGN: Clinical review.

LEVEL OF EVIDENCE: Level 4.

RESULTS: Few studies exist on the implications of macronutrient deficiencies …

Mucins, Gut Microbiota, And Postbiotics Role In Colorectal Cancer, Ramesh Pothuraju, Sanjib Chaudhary, Satyanarayana Rachagani, Sukhwinder Kaur, Hemant K Roy, Michael Bouvet, Surinder K Batra

Faculty, Staff and Students Publications

An imbalance in the crosstalk between the host and gut microbiota affects the intestinal barrier function, which results in inflammatory diseases and colorectal cancer. The colon epithelium protects itself from a harsh environment and various pathogenic organisms by forming a double mucus layer, primarily comprising mucins. Recent studies are focusing on how dietary patterns alter the gut microbiota composition, which in turn regulates mucin expression and maintains the intestinal layers. In addition, modulation of gut microbiota by microbiotic therapy (involving fecal microbiota transplantation) has emerged as a significant factor in the pathologies associated with dysbiosis. Therefore, proper communication between host …

An International Study Of Interobserver Variability Of “String Sign” Of Pancreatic Cysts Among Experienced Endosonographers, Seifeldin Hakim, Emmanuel Coronel, Graciela M Nogueras González, Philip S Ge, Suresh T Chari, Nirav Thosani, Srinivas Ramireddy, Ricardo Badillo, Tomas Davee, Marc F Catalano, Robert J Sealock, Sreeram Parupudi, Lyndon V Hernandez, Virendra Joshi, Atsushi Irisawa, Surinder Rana, Sundeep Lakhtakia, Peter Vilmann, Adrian Saftoiu, Siyu Sun, Marc Giovannini, Matthew H Katz, Michael P Kim, Manoop S Bhutani

Faculty, Staff and Students Publications

BACKGROUND AND OBJECTIVES: No single optimal test reliably determines the pancreatic cyst subtype. Following EUS-FNA, the "string sign" test can differentiate mucinous from nonmucinous cysts. However, the interobserver variability of string sign results has not been studied.

METHODS: An experienced endosonographer performed EUS-FNA of pancreatic cysts on different patients and was recorded on video performing the string sign test for each. The videos were shared internationally with 14 experienced endosonographers, with a survey for each video: "Is the string sign positive?" and "If the string sign is positive, what is the length of the formed string?" Also asked "What is …