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2021

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Fetal Us And Mri In Detection Of Craniospinal Anomalies With Postnatal Correlation:Single-Center Experience, İlker Eyüboğlu, Gülseren Di̇nç Jan 2021

Fetal Us And Mri In Detection Of Craniospinal Anomalies With Postnatal Correlation:Single-Center Experience, İlker Eyüboğlu, Gülseren Di̇nç

Turkish Journal of Medical Sciences

Background/aim: To reveal the contribution of magnetic resonance imaging (MRI) to ultrasound (US) in prenatal diagnosis of fetal craniospinal anomalies by retrospectively comparing the prenatal and postnatal findings. Materials and methods: After institutional review board approval, between January 2010 and May 2020, 301 pregnant women, which had a gestational age between 19-37 weeks (mean 26.5 ± 6.1 weeks), diagnosed with cranial and spinal anomalies on fetal US and later on imaged with MRI were evaluated, and in 179 of those cases prenatal imaging findings were compared with postnatal findings. Results: A total of 191 fetal craniospinal anomalies were detected in …

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Clinical Implications Of Fungal Isolation From Sputum In Adult Patients With Cystic Fibrosis, İli̇m Irmak, Ebru Damadoğlu, Damla Karadeni̇z Güven, Xursud Huseynova, Ahmet Çağkan İnkaya, Berri̇n Er, Ali̇ Korhan Siğ, Dolunay Gülmez Kivanç, Sevtap Arikan, Di̇lber Ademhan Tural, Deni̇z Doğru Ersöz, Hayri̇ye Uğur Özçeli̇k, Emi̇ne Nural Ki̇per, Ali̇ Fuat Kalyoncu Jan 2021

Clinical Implications Of Fungal Isolation From Sputum In Adult Patients With Cystic Fibrosis, İli̇m Irmak, Ebru Damadoğlu, Damla Karadeni̇z Güven, Xursud Huseynova, Ahmet Çağkan İnkaya, Berri̇n Er, Ali̇ Korhan Siğ, Dolunay Gülmez Kivanç, Sevtap Arikan, Di̇lber Ademhan Tural, Deni̇z Doğru Ersöz, Hayri̇ye Uğur Özçeli̇k, Emi̇ne Nural Ki̇per, Ali̇ Fuat Kalyoncu

Turkish Journal of Medical Sciences

Background/aim: Cystic fibrosis is an autosomal recessive disease with a defect in mucociliary activity that is characterized by recurrent pulmonary infections. Bacterial agents frequently implicated in airway colonization are Haemophilus influenzae, Staphylococcus spp., and Pseudomonas spp. Fungal isolation from sputum is common in adults. However, growth of fungal agent only in sputum culture in patients with cystic fibrosis is insufficient for the diagnosis of fungal diseases. There is limited data about the clinical significance of fungal isolation in sputum cultures. The aim of the study was to investigate the clinical outcomes andsignificance of fungal isolation from sputum samples in adult …

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Impact Of Frailty And Ultrasonography-Based Sarcopenia On The Development Ofpostoperative Complications In Gastrointestinal Cancer Patients, Gözde Şengül Ayçi̇çek, Ti̇muçi̇n Erol, Peli̇n Ünsal, Olgun Deni̇z, Osman Abbasoğlu, Meltem Gülhan Hali̇l Jan 2021

Impact Of Frailty And Ultrasonography-Based Sarcopenia On The Development Ofpostoperative Complications In Gastrointestinal Cancer Patients, Gözde Şengül Ayçi̇çek, Ti̇muçi̇n Erol, Peli̇n Ünsal, Olgun Deni̇z, Osman Abbasoğlu, Meltem Gülhan Hali̇l

Turkish Journal of Medical Sciences

Background/aim: Gastrointestinal (GI) system cancers are frequent among older adults and it is still difficult to predict which are at increased risk for postoperative complications. Frailty and sarcopenia are increasing problems of older population and may be associated with adverse outcomes. In this study we aimed to examine the effect of sarcopenia and frailty on postoperative complications in older patients undergoing surgery for GI cancers. Materials and methods: Forty-nine patients admitted to general surgery clinic with the diagnosis of gastrointestinal system cancers were included in this cross-sectional study. Frailty status was assessed using the Edmonton Frail Scale (EFS). Sarcopenia was …

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Turkish Validity And Reliability Study Of Type 2 Diabetes Stigma Assessment Scale, Bahar İnkaya, Ezgi̇ Karadağ Jan 2021

Turkish Validity And Reliability Study Of Type 2 Diabetes Stigma Assessment Scale, Bahar İnkaya, Ezgi̇ Karadağ

Turkish Journal of Medical Sciences

Background/aim: Stigma has a high incidence and adversely affects people with diabetes. In this context, patients face difficulties such as fear of losing their jobs, travel restrictions, isolation from social life, problems related to mental health, and feeling of wellness. The aim of this study was to investigate the validity and reliability of the stigma assessment scale in individuals with type 2 diabetes. Materials and methods: The study sample consisted of 153 diabetic individuals. The validity of language, content, and construct were examined to evaluate the validity of the type 2 diabetes stigma assessment scale. Cronbach's alpha was used to …

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Effect Of Vitamin D Supplementation On Lower Extremity Motor Function And Ambulationin Stroke Patients, Ayça Utkan Karasu, Gülçi̇n Kaymak Karataş Jan 2021

Effect Of Vitamin D Supplementation On Lower Extremity Motor Function And Ambulationin Stroke Patients, Ayça Utkan Karasu, Gülçi̇n Kaymak Karataş

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the effect of vitamin D supplementation on ambulation and mobility in hospitalized patients undergoing stroke rehabilitation. Materials and methods: This study was conducted retrospectively between September 2020 and October 2020 at Gazi University Faculty of Medicine Physical Medicine and Rehabilitation Department. Seventy-six patients who received inpatient stroke rehabilitation treatment between May 2018 and February 2020 were included in the study. The patients were divided into two groups as those who did and did not take vitamin D supplements. Lower extremity motor function and ambulation status were compared using Brunnstrom recovery stage …

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The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal Jan 2021

The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal

Turkish Journal of Medical Sciences

Background/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)2 D3 was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)2 D3 treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats. Materials and methods: Rats were treated with fructose (30%) or ethanol (5-20%) in drinking water with and without 1,25(OH)2 D3 treatment (5 µg/kg two times a week) for 8 weeks. …

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What Is The Main Factor In Predicting The Morbidity And Mortality In Patients Withgastroschisis: Delivery Time, Delivery Mode, Closure Method, Or The Type Of Gastroschisis(Simple Or Complex)?, Mustafa Behram, Süleyman Cemi̇l Oğlak, Seyi̇than Özaydin, Sema Süzen Çaypinar, İlker Gönen, Şeyhmus Tunç, Yusuf Başkiran, İsmai̇l Özdemi̇r Jan 2021

What Is The Main Factor In Predicting The Morbidity And Mortality In Patients Withgastroschisis: Delivery Time, Delivery Mode, Closure Method, Or The Type Of Gastroschisis(Simple Or Complex)?, Mustafa Behram, Süleyman Cemi̇l Oğlak, Seyi̇than Özaydin, Sema Süzen Çaypinar, İlker Gönen, Şeyhmus Tunç, Yusuf Başkiran, İsmai̇l Özdemi̇r

Turkish Journal of Medical Sciences

Background/aim: There are numerous debates in the management of gastroschisis (GS). The current study aimed to evaluate perinatal outcomes and surgical and clinical characteristics among GS patients based on their type of GS, abdominal wall closure method, and delivery timing. Materials and methods: This study was a retrospective analysis of prospectively collected data of 29 fetuses with GS that were prenatally diagnosed, delivered, and managed between June 2015 and December 2019 at the Obstetrics and Pediatric Surgery Clinics of Kanuni Sultan Süleyman Training and Research Hospital. Results: Twenty-three of the patients had simple GS, and six of them had complex …

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The Histopathological Effects Of Reabsorbable Polyethylene Glycol Hydrogel (Coseal) Onepidural Fibrosis In An Experimental Postlaminectomy Model In Rats, Emrah Keski̇n, Hasan Ali̇ Aydin, Murat Kalayci, Emre Işik, Utku Özgen, Kenan Şi̇mşek, Deni̇z Baklaci, Mertol Gökçe Jan 2021

The Histopathological Effects Of Reabsorbable Polyethylene Glycol Hydrogel (Coseal) Onepidural Fibrosis In An Experimental Postlaminectomy Model In Rats, Emrah Keski̇n, Hasan Ali̇ Aydin, Murat Kalayci, Emre Işik, Utku Özgen, Kenan Şi̇mşek, Deni̇z Baklaci, Mertol Gökçe

Turkish Journal of Medical Sciences

Background/aim: To investigate the histopathological effects of reabsorbable polyethylene glycol hydrogel (RPGH, Coseal) on epidural fibrosis (EF) following laminectomy in rats. Materials and methods: A total of 24 rats were equally divided into three groups. In the first group, no treatment was applied after laminectomy (control group, Group 1). In the second group, hemostasis was achieved after laminectomy, and 2 mm absorbable gelatin sponge soaked in saline was placed over the epidural space and the wound was closed (Group 2). In the third group, hemostasis was achieved following laminectomy, and 0.5 mL RPGH (Coseal, Group 3) was squeezed over the …

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Nutritional Status In Patients With Neuro-Behçet's Disease, Seyda Erdoğan, Mi̇ne Hayri̇ye Sorgun, Müge Kuzu Kumcu, Mustafa Aykut Kural, Sefer Rzayev, Canan Yücesan Jan 2021

Nutritional Status In Patients With Neuro-Behçet's Disease, Seyda Erdoğan, Mi̇ne Hayri̇ye Sorgun, Müge Kuzu Kumcu, Mustafa Aykut Kural, Sefer Rzayev, Canan Yücesan

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to assess the nutritional status and risk factors for malnutrition in Behçet's disease (BD) and neuro-Behçet's disease (NBD) patients. Materials and methods: Medical recordings of 74 patients with BD without neurological involvement (BDWoNI), 72 patients with NBD, and 50 patients with other diseases (carpal tunnel syndrome or lumbar discopathy) were analyzed retrospectively. The serum analyses were performed in the inactive period of disease. Chronic malnutrition was defined as low levels of serum albumin (

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Decreased Exercise Capacity, Strength, Physical Activity Level And Quality Of Life In Adultpatients With Familial Mediterranean Fever, Nurten Gi̇zem Tore, Fulden Sari̇, Devri̇m Can Saraç, Seli̇n Bayram, Hasan Satiş, Hazan Karadeni̇z, Abdurrahman Tufan, Deran Oskay Jan 2021

Decreased Exercise Capacity, Strength, Physical Activity Level And Quality Of Life In Adultpatients With Familial Mediterranean Fever, Nurten Gi̇zem Tore, Fulden Sari̇, Devri̇m Can Saraç, Seli̇n Bayram, Hasan Satiş, Hazan Karadeni̇z, Abdurrahman Tufan, Deran Oskay

Turkish Journal of Medical Sciences

Background: Familial Mediterranean fever (FMF) is a systemic autoinflammatory disease that causes recurrent attacks of fever, polyserositis, arthritis or skin eruptions, resulting in pain in the abdomen, muscles, joints and chest. All of these might lead to a reduction in exercise capacity, muscle strength, physical activity level (PAL) and quality of life (QoL). Therefore, assesment of these parameters are important. The aim of this study was to assess exercise capacity, muscle strength, PAL, and QoL in patients with FMF as compared to controls. Materials and methods: A total of 40 subjects with FMF and 36 healthy control subjects participated in …

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The Relationship Of Carotid Intima-Media Thickness With Anthropometric And Metabolicparameters In Patients With Classic Congenital Adrenal Hyperplasia, Hale Ünver Tuhan, Tülay Öztürk Atasoy, Gönül Çatli, Sezer Acar, Ayhan Abaci, Tuğba Üçüncü Egeli̇, Korcan Demi̇r, Penbe Şule Can, Handan Güleryüz, Bumi̇n Nuri̇ Dündar, Ece Böber Jan 2021

The Relationship Of Carotid Intima-Media Thickness With Anthropometric And Metabolicparameters In Patients With Classic Congenital Adrenal Hyperplasia, Hale Ünver Tuhan, Tülay Öztürk Atasoy, Gönül Çatli, Sezer Acar, Ayhan Abaci, Tuğba Üçüncü Egeli̇, Korcan Demi̇r, Penbe Şule Can, Handan Güleryüz, Bumi̇n Nuri̇ Dündar, Ece Böber

Turkish Journal of Medical Sciences

Background/aim: We aimed to determine the presence of subclinical atherosclerosis using carotid intima-media thickness (CIMT) and biochemical parameters in children and adolescents with congenital adrenal hyperplasia (CAH). Materials and methods: Thirty-four patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency on regular glucocorticoid treatment for ≥3 years and 31 healthy subjects were included in the study. The patients were divided into two groups according to the degree of control of the clinic, laboratory, and radiological parameters as a) "uncontrolled" [n= 22; with increased height velocity (HV) standard deviation score (SDS) (≥2 SDS), advanced bone age, serum 17-OH progesterone 0.05]. …

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Reference Values For T And B Lymphocyte Subpopulations In Turkish Children And Adults, Özge Besci̇, Di̇lek Başer, İsmai̇l Öğülür, Ayşe Cansu Berberoğlu, Ayça Kiykim, Tolga Besci̇, Asim Leblebi̇ci̇, Hülya Elli̇dokuz, Perran Boran, Eren Özek, Goncagül Haklar, Ahmet Oğuzhan Özen, Safa Bariş, Eli̇f Aydiner Jan 2021

Reference Values For T And B Lymphocyte Subpopulations In Turkish Children And Adults, Özge Besci̇, Di̇lek Başer, İsmai̇l Öğülür, Ayşe Cansu Berberoğlu, Ayça Kiykim, Tolga Besci̇, Asim Leblebi̇ci̇, Hülya Elli̇dokuz, Perran Boran, Eren Özek, Goncagül Haklar, Ahmet Oğuzhan Özen, Safa Bariş, Eli̇f Aydiner

Turkish Journal of Medical Sciences

Background/aim: Established reference values are critical for the interpretation of immunologic assessments. In particular, the proportion and absolute counts of T- and B- cell subpopulations are subject to change with age and ethnicity. We aimed to establish agespecific reference values for lymphocyte subsets using updated immunophenotyping panels. Materials and methods: We studied a total of 297 healthy Turkish subjects aged 0 to 50 years, stratified into major age brackets in a cluster factor of 10 per age-group. The predetermined age intervals contained randomly allocated participants enrolled over a period of 6 months, who were homogenously distributed by sex. We analyzed …

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Utilization Of Biotechnological Drugs In Rare Diseases Requiring The Use Of Off-Label Drugsin Children In Turkey, Neri̇man İpek Kirmizi, Volkan Aydin, Nari̇n Akici, Banu Bayar, Ahmet Akici Jan 2021

Utilization Of Biotechnological Drugs In Rare Diseases Requiring The Use Of Off-Label Drugsin Children In Turkey, Neri̇man İpek Kirmizi, Volkan Aydin, Nari̇n Akici, Banu Bayar, Ahmet Akici

Turkish Journal of Medical Sciences

Background/aim: Pediatric patients, especially those with rare diseases, represent a population that has a high tendency towards offlabel drug use (OLDU) and needs a more careful practice of pharmacotherapy than in adults. We aimed to investigate biotechnological drug use in children with rare diseases requiring OLDU. Materials and methods: This retrospective study examined all single-diagnosed OLDU applications (n = 5792) for 4992 children (

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The Contribution Of Postnatal Steroid Administration To Early Brain Damage In Pretermbabies With Bronchopulmonary Dysplasia, Sabahatti̇n Ertuğrul, Savaş Mert Darakci̇, İbrahi̇m Kaplan, İlyas Yolbaş, İbrahi̇m Deger, Si̇bel Tanriverdi̇ Yilmaz, Şerafetti̇n Aktaş Jan 2021

The Contribution Of Postnatal Steroid Administration To Early Brain Damage In Pretermbabies With Bronchopulmonary Dysplasia, Sabahatti̇n Ertuğrul, Savaş Mert Darakci̇, İbrahi̇m Kaplan, İlyas Yolbaş, İbrahi̇m Deger, Si̇bel Tanriverdi̇ Yilmaz, Şerafetti̇n Aktaş

Turkish Journal of Medical Sciences

Background/aim: Postnatal corticosteroids are commonly used to treat bronchopulmonary dysplasia (BPD). We aimed to show whether S100 calcium-binding B (S100B), neuron-specific enolase (NSE), Tau protein or microtubule-associated protein tau (MAPT), and glial fibrillary acid protein (GFAP) levels would provide any evidence of early neurological damage in premature infants receiving postnatal low dose dexamethasone therapy for BPD treatment. Materials and methods: In this cohort study, 136 preterm infants diagnosed with BPD at ≤ 32 weeks of gestation formed the study group, and 64 preterm infants formed the control group. NSE, S100B, GFAP, and MAPT levels were first measured before the postnatal …

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Serum Growth Differentiation Factor-15 Analysis As A Malnutrition Marker Inhemodialysis Patients, Di̇dem Turgut, Deni̇z İlhan Topcu, Cemi̇le Cansu Alperen, Sidika Esra Baskin Jan 2021

Serum Growth Differentiation Factor-15 Analysis As A Malnutrition Marker Inhemodialysis Patients, Di̇dem Turgut, Deni̇z İlhan Topcu, Cemi̇le Cansu Alperen, Sidika Esra Baskin

Turkish Journal of Medical Sciences

Background/aim: Growth differentiation factor (GDF)-15 is related to inflammation and mortality in many conditions. We aimed to determine if an elevated serum GDF-15 level is related to nutritional status of patients on hemodialysis (HD) and mortality. Materials and methods: Routine HD patients (n = 158) were included in the study and followed for 18 months. Some malnutrition/ inflammation scoring indexes (malnutrition/inflammation score (MIS), controlling nutritional status (CONUT) score, and prognostic nutritional index (PNI)), biochemical parameters, and GDF-15 were used to build Cox regression multivariate models to study the association with mortality. Results: Among the patients, 90 (57 %) had a …

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Volume And T2 Relaxation Time Measurements Of Quadriceps Femoris And Hamstringmuscles Are Reliable And Reproducible, Şeri̇fe Şeyma Torğutalp, Ömer Özkan, Şafak Parlak Sağol, Hati̇ce Kader Karli Oğuz, Feza Korkusuz Jan 2021

Volume And T2 Relaxation Time Measurements Of Quadriceps Femoris And Hamstringmuscles Are Reliable And Reproducible, Şeri̇fe Şeyma Torğutalp, Ömer Özkan, Şafak Parlak Sağol, Hati̇ce Kader Karli Oğuz, Feza Korkusuz

Turkish Journal of Medical Sciences

Background/aim: Volume and T2 relaxation time measurements of the skeletal muscle provide quantitative information. We aimed to evaluate the interobserver reliability and the intraobserver reproducibility of measurements of volumes and T2 relaxation times of the quadriceps femoris and the hamstring muscles. Materials and methods: A cross-sectional reliability study was conducted on ten recreational athletes. The images of the quadriceps and the hamstring muscles of both limbs were obtained using a 3.0 Tesla magnetic resonance imaging (MRI) scanner. Two sports medicine specialists measured muscle volumes from a total of 2560 images and T2 relaxation times from a total of 40 images, …

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Effect Of Decompressive Hemicraniectomy In Patients With Acute Middle Cerebral Arteryinfarction, Hali̇l İbrahi̇m Süner, Anil Tanburoğlu, Emre Durdağ, Soner Çi̇vi̇, Ayli̇n Güneşli̇ Yeti̇şken, Özgür Kardeş, Çağatay Andi̇ç, Kadi̇r Tufan Jan 2021

Effect Of Decompressive Hemicraniectomy In Patients With Acute Middle Cerebral Arteryinfarction, Hali̇l İbrahi̇m Süner, Anil Tanburoğlu, Emre Durdağ, Soner Çi̇vi̇, Ayli̇n Güneşli̇ Yeti̇şken, Özgür Kardeş, Çağatay Andi̇ç, Kadi̇r Tufan

Turkish Journal of Medical Sciences

Background/aim: We aimed to determine in which cases this procedure may be more effective based on the data of patients who underwent decompressive hemicraniectomy (DHC). Material and methods: Overall, 47 patients who underwent DHC due to acute middle cerebral artery (MCA) infarction between January 2014 and january 2019 were retrospectively investigated. These patients were divided into two groups: those who died after DHC (Group A) and those who survived DHC (Group B). The groups were compared in terms of various parameters. We investigated whether the patient's modified Rankin scale (mRS) status changed depending on age (> 60 and < 60 years). Results: The median age of all patients was 65 (37-80) years; groups A and B had median ages of 66.5 (37-80) and 61 (44-79) years (p = 0.111), respectively; 55.3% patients were male. The elapsed times until hospitalization after the onset of symptoms were 4.5 and 3 h in groups A and B, respectively (p = 0.014). The median GCS score at the time of admission was 7 (5-12) and 10 (8-14) in groups A and B, respectively (p = 0.0001). At the time of admission, 63.3% patients in group A had anisocoria, whereas no patient in group B had anisocoria (p = 0.0001). In postoperative period, 40% patients in group A and all patients in group B received AC/AA treatment. The survival of patients aged < 60 and > 60 years …

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Dental And Temporomandibular Joint Alterations In Rheumatoid Arthritis Patients Andtheir Association With Salivary Oxidative Stress, Deni̇z Yaman, Duygu Göller Bulut, Gülbahar Ustaoğlu, Emre Avci, Murat Taşçi Jan 2021

Dental And Temporomandibular Joint Alterations In Rheumatoid Arthritis Patients Andtheir Association With Salivary Oxidative Stress, Deni̇z Yaman, Duygu Göller Bulut, Gülbahar Ustaoğlu, Emre Avci, Murat Taşçi

Turkish Journal of Medical Sciences

Background/aim: Rheumatoid arthritis (RA) is the most extensive inflammatory arthritis causing permanent deformities in the joint. Increasing evidence suggests that oxidative stress is a substantial factor in the pathogenesis of RA. This study aimed to examine the salivary oxidant-antioxidant status of RA and control groups and to compare these biomarkers by correlating them with disease activity, acute phase reactants, and clinical findings. Materials and methods: Age and sex-matched 60 participants including 30 patients with RA and 30 control (50 females, 10 males; mean age: 42.62 ± 10.89 years) were evaluated. RA disease activity and severity were evaluated by the disease …

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An Alternative Supplemental Feeding Method For Preterm Infants: The Supplementalfeeding Tube Device, Müjde Çalikuşu İncekar, Seda Çağlar, Fatma Kaya Narter, Emri̇ye Tercan Tarakci, Emi̇ne Özpinar, Esra Demi̇rci̇ Ecevi̇t Jan 2021

An Alternative Supplemental Feeding Method For Preterm Infants: The Supplementalfeeding Tube Device, Müjde Çalikuşu İncekar, Seda Çağlar, Fatma Kaya Narter, Emri̇ye Tercan Tarakci, Emi̇ne Özpinar, Esra Demi̇rci̇ Ecevi̇t

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was to determine the effects of the supplemental feeding tube device (SFTD) and bottle methods on weight gain, transition to full breastfeeding, breastfeeding success, and duration of discharge in preterm infants. Materials and methods: This randomized controlled trial was conducted with a total of 46 preterm infants including 23 infants in study (SFTD) and control (bottle) groups. An information form, an infant follow-up form for feeding, and LATCH breastfeeding assessment instrument were used to collect the data. Results: The gestation week of the infants in the study group was 31.22 ± 2.76, and in …

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Is Conut Score A Prognostic Index In Patients With Diffuse Large Cell Lymphoma?, Gülsüm Akgün Çağliyan, Si̇bel Hacioğlu, Başak Ünver Koluman, Kadi̇r İlkkiliç, Ruki̇ye Nar, Mehmet Nuri̇ Başer, Asli Bozdemi̇r, Hande Şenol, Ni̇lay Şen Türk, Veysel Erol, Onurcan Yildirim, Ömer Çağliyan, Ni̇l Güler Jan 2021

Is Conut Score A Prognostic Index In Patients With Diffuse Large Cell Lymphoma?, Gülsüm Akgün Çağliyan, Si̇bel Hacioğlu, Başak Ünver Koluman, Kadi̇r İlkkiliç, Ruki̇ye Nar, Mehmet Nuri̇ Başer, Asli Bozdemi̇r, Hande Şenol, Ni̇lay Şen Türk, Veysel Erol, Onurcan Yildirim, Ömer Çağliyan, Ni̇l Güler

Turkish Journal of Medical Sciences

Background/aim: The aim of the study was to evaluate the effect of Controlling Nutritional Status (CONUT) score on the prognosis in patients with diffuse large B-cell lymphoma (DLBCL). Materials and methods: The present study was a retrospective study. The CONUT score was calculated based on serum albumin, total cholesterol and lymphocyte levels. This study included a total of 266 patients, 131 (49.2%) were female and 135 (50.8%) were male. The median follow-up period was 51 months (range: 1-190). Results: The median age was 64 years. The cut off CONUT was 1.5. There was a significant difference between patients with high …

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Effects Of Tacrolimus On C-Fos In Hippocampus And Memory Performances Instreptozotocin Model Of Alzheimer's Disease Of Rats, Ayşe Köylü, Berri̇n Zühal Altunkaynak, Burcu Deli̇baş Jan 2021

Effects Of Tacrolimus On C-Fos In Hippocampus And Memory Performances Instreptozotocin Model Of Alzheimer's Disease Of Rats, Ayşe Köylü, Berri̇n Zühal Altunkaynak, Burcu Deli̇baş

Turkish Journal of Medical Sciences

Background/aim: Calcineurin, an inhibitor of calcium dependent phosphatase is highly presented in a brain of an Alzheimer?s disease. Aging brain gets more sensitive to hyperactivation of calcineurin, and this event causes tau neurofibrillary plaque accumulation, which is one of the outcomes of this disease. The regions of hippocampus are much effected from the results of this process. Our hypothesis is that a calcineurin inhibitor, tacrolimus, could prevent the accumulation and the decrease of the neuronal cells. Therefore, this immunosuppressive drug could be a candidate for an early treatment of Alzheimer disease. Materials and methods: Fifteen male Wistar albino rats were …

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Lutein/Zeaxanthin Isomers Regulate Neurotrophic Factors And Synaptic Plasticity Intrained Rats, Cemal Orhan, Füsun Erten, Beşi̇r Er, Mehmet Tuzcu, Nurhan Şahi̇n, Öznur Ece Durmaz Kurşun, Vijaya Juturu, Kazi̇m Şahi̇n Jan 2021

Lutein/Zeaxanthin Isomers Regulate Neurotrophic Factors And Synaptic Plasticity Intrained Rats, Cemal Orhan, Füsun Erten, Beşi̇r Er, Mehmet Tuzcu, Nurhan Şahi̇n, Öznur Ece Durmaz Kurşun, Vijaya Juturu, Kazi̇m Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: This study was conducted to elucidate the effects of lutein/zeaxanthin isomers (L/Zi) on lipid metabolism, oxidative stress, NF-ΚB/Nrf2 pathways, and synaptic plasticity proteins in trained rats. Materials and methods: Wistar rats were distributed into four groups: 1) control, 2) L/Zi: rats received L/Zi at the dose of 100 mg/kg by oral gavage, 3) exercise, 4) exercise+L/Zi: rats exercised and received L/Zi (100 mg/kg) by oral gavage. The duration of the study was eight weeks. Results: Exercise combined with L/Zi reduced lipid peroxidation and improved antioxidant enzyme activities of muscle and cerebral cortex in rats (p < 0.001). In the Exercise + L/Zi group, muscle and cerebral cortex Nrf2 and HO-1 levels increased, while NF-ΚB levels decreased (p

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Effects Of Intracerebroventricularly Administered Opioid Peptide Antagonistson Tissue Glycogen Levels In Rats After Exercise, Ayşe Şebnem İlhan, Şevi̇n Güney, Si̇bel Di̇ncer Jan 2021

Effects Of Intracerebroventricularly Administered Opioid Peptide Antagonistson Tissue Glycogen Levels In Rats After Exercise, Ayşe Şebnem İlhan, Şevi̇n Güney, Si̇bel Di̇ncer

Turkish Journal of Medical Sciences

Background/aim: Physical exercise is a state of physiological stress that requires adaptation of the organism to physical activity. Glycogen is an important and essential energy source for muscle contraction. Skeletal muscle and liver are two important glycogen stores, and the energy required to maintain exercise in rodents are provided by destruction of this glycogen depot. In this study, the effects of endogenous opioid peptide antagonism at the central nervous system level on tissue glycogen content after exhaustive exercise were investigated. Materials and methods: Rats had intracerebroventricularly (icv) received nonspecific opioid peptide receptor antagonist, naloxone (50 μ/10 μL in saline) and …

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Effects Of Regular Whey Protein Consumption On Rat Thyroid Functions, Gökhan Akkurt, Bahar Kartal, Mustafa Ali̇moğullari, Sevi̇l Çayli, Ebru Ali̇moğullari Jan 2021

Effects Of Regular Whey Protein Consumption On Rat Thyroid Functions, Gökhan Akkurt, Bahar Kartal, Mustafa Ali̇moğullari, Sevi̇l Çayli, Ebru Ali̇moğullari

Turkish Journal of Medical Sciences

Background/aim: We aimed to investigate whether there was a significant difference in TSH, T3, T4 values and histopathologically evaluated thyroid tissues between rats that received ısole hydrolyzed whey protein (IHWP) at different doses regularly and rats fed with only standard feed. Material & methods: Total 24 rats were randomly divided into three groups with 8 rats in each group. First group were fed with standard feed for 12 weeks. Second group were given standard feed + daily 0.3 g/kg IHWP and rats in the third group standard feed + 0.5 g/kg IHWP for 12 weeks. Blood samples were collected from …

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Cover And Contents Jan 2021

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

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Natural Animal Food Preference Of Chinese Mole Shrew (Anourosorex Squamipes) From An Urban Area: A Laboratory Study, Yun-Chun Ye, Yi Luo, Zhao-Min Zhou Jan 2021

Natural Animal Food Preference Of Chinese Mole Shrew (Anourosorex Squamipes) From An Urban Area: A Laboratory Study, Yun-Chun Ye, Yi Luo, Zhao-Min Zhou

Turkish Journal of Zoology

Most wild animals are urban avoiders, but some others become adapters or exploiters successfully living in urban areas. Often, the latter is assumed to be attracted into cities by readily accessible and digestive anthropogenic food resources. Here, we quantified food preferences of sixteen (eight females and eight males) Chinese mole shrews (Anourosorex squamipes) captured from an urban area for "cafeteria tests" in laboratory. Shrews were presented with twelve foods allocated into three sets (natural animal, natural plant, and anthropogenic food). Once the most two highly consumed food items from each set were determined, six items were pooled together to form …

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A Sensitive Indicator For The Severity Of Covid-19: Thiol, Özcan Erel, Sali̇m Neşeli̇oğlu, Merve Ergi̇n Tunçay, Esra Firat Oğuz, Funda Eren, Meryem Sena Akkuş, Hati̇ce Rahmet Güner, İhsan Ateş Jan 2021

A Sensitive Indicator For The Severity Of Covid-19: Thiol, Özcan Erel, Sali̇m Neşeli̇oğlu, Merve Ergi̇n Tunçay, Esra Firat Oğuz, Funda Eren, Meryem Sena Akkuş, Hati̇ce Rahmet Güner, İhsan Ateş

Turkish Journal of Medical Sciences

Background/aim: Thiol status is a good reflector of the cellular redox and have vital roles in various cellular signaling pathways. The purpose of the study was to investigate thiol status in patients with SARS-CoV-2 infection. Materials and methods: A total of 587 subjects (517 patients/70 healthy controls) were enrolled in the study.The patients were categorized into the groups regarding to the severity of disease (mild, moderate, severe, and critical).Thiol status of all groups were compared. Results: The patients had significantly diminished thiol levels compared to controls. Thiol levels were gradually decreased as the severity of the disease increased. Logistic regression …

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Could Serum Albumin Value And Thrombocyte/Lymphocyte Ratio Be An Importantprognostic Factor In Determining The Severity Of Covid 19?, Emel Uyar, Alparslan Merdi̇n, Serdar Yamanyar, Mehmet Can Ezgü, Cumhur Artuk, Gürhan Taşkin, Yakup Arslan, Serkan Ceri̇tli̇ Jan 2021

Could Serum Albumin Value And Thrombocyte/Lymphocyte Ratio Be An Importantprognostic Factor In Determining The Severity Of Covid 19?, Emel Uyar, Alparslan Merdi̇n, Serdar Yamanyar, Mehmet Can Ezgü, Cumhur Artuk, Gürhan Taşkin, Yakup Arslan, Serkan Ceri̇tli̇

Turkish Journal of Medical Sciences

Background and aim: Creating potential clinical markers for risk assessment in patients with COVID-19 continues to be an area of interest. In this study, we aimed to evaluate whether serum albumin level and thrombocyte/lymphocyte ratio are related to the severity of the disease. Materials and methods: The patients were divided into two groups according to the severity of disease. Demographic data, serum albumin value, lymphocyte count, TLO-1 values (thrombocyte/lymphocyte ratio-1), the highest thrombocyte count during hospitalization, TLO-2 (thrombocyte/lymphocyte ratio-2) values formed by the highest thrombocyte count, were recorded. Results: There was no statistically significant differences (P > 0.05) in terms of …

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Is Microrna 1910-3p (Mir-1910-3p) A Really Distinctive Marker For Psoriasis?, Melek Karabacak, İjlal Erturan, Kuyaş Heki̇mler Öztürk, Havva Hi̇lal Ayvaz, Selma Korkmaz, Mehmet Yildirim, Hi̇kmet Orhan Jan 2021

Is Microrna 1910-3p (Mir-1910-3p) A Really Distinctive Marker For Psoriasis?, Melek Karabacak, İjlal Erturan, Kuyaş Heki̇mler Öztürk, Havva Hi̇lal Ayvaz, Selma Korkmaz, Mehmet Yildirim, Hi̇kmet Orhan

Turkish Journal of Medical Sciences

Background/aim: Although the cause of immune activation in the pathogenesis of psoriasis is still unclear, miRs are thought to have an effect on psoriasis. This work aimed to evaluate the role of miRs (miR-4649-3p, miR-6867-5p, miR-4296, miR-210, and miR-1910-3p) that target the FOXP3 mRNA and IL-17A mRNA in psoriasis. Materials and methods: Forty-four psoriasis patients and 44 healthy controls were included in the study. Quantitative real-time PCR (qRT-PCR) was used for the measurement of miRs. Serum IL-17A levels were determined by an enzyme-linked immunosorbent assay (ELISA) method. Results: Plasma miR-1910-3p levels were significantly lower in the patient group than the …

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Ruminal Kinetics Of Carbohydrates, Gas Production And Bromatology Of Sugarcane Silagewith High Levels Of Sodium Benzoate, Celso Heinzen Junior, Odimári Pricila Prado Calixto, Egon Henrique Horst, Leonardo Trolegi, Fernando Luiz Massaro Junior, Ivone Yurika Mizubuti, Mikael Neumann, Valter Harry Bumbieris Junior Jan 2021

Ruminal Kinetics Of Carbohydrates, Gas Production And Bromatology Of Sugarcane Silagewith High Levels Of Sodium Benzoate, Celso Heinzen Junior, Odimári Pricila Prado Calixto, Egon Henrique Horst, Leonardo Trolegi, Fernando Luiz Massaro Junior, Ivone Yurika Mizubuti, Mikael Neumann, Valter Harry Bumbieris Junior

Turkish Journal of Veterinary & Animal Sciences

The objective of this study was to evaluate the chemical composition, ruminal kinetics, gas production and aerobic stability of sugarcane silage added with increasing levels of sodium benzoate up to 1% of the natural matter. After harvesting, the sugarcane was chopped and placed in experimental polyethylene silos for storage for 30 days. An increasing concentration of sodium benzoate in the silage promoted a linear decrease in the crude protein content, varying from 2.79% to 2.51%. The addition of sodium benzoate reduced the fiber concentration of the silage (P = 0.0015) and increased gas production of the fibrous and nonfibrous carbohydrates …

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