Digital Commons Network^™

Morphological Changes In Dorsal Root Ganglia Macrophages Associated With Neuropathic Pain Mechanisms Suggest A Novel Target For Chronic Pain Therapy, Emily Kussick

CMC Senior Theses

The present study examined morphological changes in the dorsal root ganglia (DRG) following an innate immune stimulus. The importance of the DRG has increasingly become recognized in pain processing as more than just the home of primary afferent cell bodies. All sensory information passes through the DRG via the primary afferents, and on to the spinal cord. The primary afferents synapse with second-order neurons in the spinal cord that ascend towards the brain, where they transmit the pain signal to the limbic forebrain and/or the somatosensory cortex for processing. The DRG is an interesting niche to study at as it …

Asian American Voting During The 2020 Elections: A Rising, Divided Voting Group, Vi Nguyen

CMC Senior Theses

Asian Americans continue to be an untapped force within American politics. Despite their status as the fastest-growing racial or ethnic group in the United States they have had surprisingly low political participation rates.[1] But 2020 represented a watershed moment. Campaign outreach and voter participation increased, and Asian Americans assumed new prominence on the national stage. Nonetheless, the 2020 elections also demonstrate historical divides within the community and a lack of cohesion as a voting group.

This thesis investigates Asian American voter behavior during the 2020 election and links trends within this year's elections to assess Asian American panethnicity. It …

Twin Threats: The Short-Sighted Us Response To Global Climate Change And Pandemics, Bryan Williams

CMC Senior Theses

This thesis examines the failure of the United States government to mitigate global climate change and the COVID-19 pandemic by comparing poor public reactions and governmental administration between the two threats. Using developmental constructs to serve as a framework for assessing public reactions to climate change and pandemics, this thesis implements a content analysis study of American news media from 2000 to 2020; it identifies the rhetoric embedded in communications that has directed the US public’s focus of attention and shaped public opinion on these issues. The results indicate significantly less focus of attention on human health issues than economic …

Essential Or Disposable?: Healthcare Workers' Right To Refuse Hazardous Work, Christa Coryea

Fordham Urban Law Journal

No abstract provided.

The Relationship Between Land Use Change And Disease Prevalence, Allison Bjornstad

Biology and Microbiology Graduate Students Plan B Research Projects

Zoonotic disease outbreaks are becoming more novel and are increasing in frequency. This increase can be partially attributed to land use changes including deforestation, urbanization, and cultivation. Land use change alters disease prevalence by causing an increase in contact rates between disease hosts and humans. Land use changes also alter species compositions in the area to contain more competent disease hosts. Each pathogen can react to these changes in different ways. The specific reactions that each pathogen has to land use changes should be further researched so proper mitigation steps can be taken. Once the effects of land use change …

A Qualitative Study On Pediatric Health Concerns In Ghana, Jordan Coldwell, Meghan Edalgo, Shannon Hester, Megan Johnston, Audrey Simon, Karley Wills, Patricia Catts, Phd, Rn

Anna Vaughn School of Nursing Undergraduate Work

Children in Ghana face health challenges that are magnified by the high cost of health care and limited access to resources. Ghanaian children suffer consequences from illnesses such as malaria, respiratory infections, gastrointestinal disturbances, sickle cell disease, injuries and accidents, and seizures. It is important to recognize the prominent diseases of this population so that funding can be allocated to relieve the burdens caused by the disease progression. This study aims to explore the health care needs of Ghanaian children and answer the question, “What are the significant health care concerns of the pediatric population in Ghana, Africa as perceived …

Non-Communicable Diseases And Social Media: A Heart Disease Symptoms Application, Ashwin Kumar Thandapani Kumarasamy, Daniel Asamoah, Ramesh Sharda

Management Information Systems Faculty Publications

Social media platforms have become ubiquitous and allow users to share information in real-time. Our study uses data analytics as an approach to explore non-communicable diseases on social media platforms and to identify trends and patterns of related disease symptoms. Exploring epidemiological patterns of non-communicable diseases is vital given that they have become prevalent in low income communities, accounting for about 38 million deaths worldwide.

We collected data related to multiple disease conditions from the Twitter microblogging platform and zoomed into symptoms related to heart diseases. As part of our analyses, we focused on the mechanism and trends of disease …

Teeka Tehreek: Increasing Epi Vaccinations In Khyber Pakhtunkhwa, Pakistan, Narjis Fatima Hussain

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Abstract

Globally, Pakistan ranks third among countries with the most unvaccinated and under-vaccinated children. Within the country, there are huge regional disparities, and the Khyber Pakhtunkhwa region (KPK FATA) has one of the lowest vaccination rates in the country. Low vaccination rates contribute to the high burden of childhood infectious diseases in Pakistan that cause 70% of childhood deaths. Addressing the issue requires an understanding of the barriers towards vaccinations; 30% of refusals are due to religious reasons and other misconceptions that are compounded by low literacy rates. Since religion has a critical authority in shaping the population’s beliefs, attitudes, …

Needs Assessment, Program Development, And Pilot Testing: Training For Occupational Therapy Students Working With Survivors Of Gun Violence, Lea Fang, Aisha Mohammed, Vicki Kaskutas

Journal of Occupational Therapy Education

After the first year of operation, members of a student-staffed occupational therapy (OT) clinic found that 36% of their patients’ injuries were violence-related, mostly due to gun violence. The purposes of this project were to identify unmet needs of survivors of violence seen in a clinic setting, identify treating professionals’ preparedness to meet these needs, and develop and pilot test a program within the scope of OT to address these needs. A literature review and key informant interviews, surveys, and focus groups identified potential solutions to address gaps between patients’ needs and professionals’ preparedness to meet those needs. The need …

Pandemics, Paid Sick Leaves, And Tax Institutions, Alex Zhang

Faculty Articles

The COVID-19 pandemic is currently ravaging the world, and the United States has been largely unsuccessful at containing the coronavirus. One long-standing policy failure stands out as having exacerbated the pandemic in our country: the lack of a national mandate of paid sick leaves, without which workers face financial and workplace-cultural pressures to attend work while sick, thus spreading the virus to their fellow employees and the public at large.

This Article provides the blueprint for a national, subsidized mandate of paid sick leaves and two additional insights about our tax institutions as mechanisms of effectuating broader societal goals. It …

Experience Of Community Violence Exposure Among Adolescents In Makassar, Indonesia, Andi Nurdini Yuridna Yudha

Chulalongkorn University Theses and Dissertations (Chula ETD)

Violence has been recognized as a global public health issue. The consequences go beyond one's health and socioeconomic well-being; it is a serious violation of human rights and security. Growing up in the midst of societal violence have proven to have impacts to adolescents social, emotional, behavioral, and cognitive development. This study examines the association among sociodemographic, perception of aggressive behavior, perception of problem behavior, and history of drug abuse, towards the experience of community violence exposure (SEVC) among adolescents in Makassar Indonesia. Cross-sectional study were used to measure experience using online questionnaire, and Self-report of SEVC. The results out …

Comparing The Effectiveness Of Lumbar Rotation To Central Posteroanterior Mobilization In The Treatment Of Individuals With Bilateral Non-Specific Low Back Pain, Nalinee Eitssayeam

Chulalongkorn University Theses and Dissertations (Chula ETD)

To compare the effectiveness of lumbar rotation mobilization and central posteroanterior (central PA) mobilization on the intensity of low back pain (LBP), lumbar range of motion (LROM), functional rating index (FRI), and global perceived effect (GPE) in individuals with bilateral non-specific low back pain (NSLBP). Seventy bilateral NSLBP individuals were recruited (19 men and 51 females). The participants were randomly assigned into two groups using concealed opaque envelopes: central PA or rotation. Both groups got a placebo treatment with detuned shortwave diathermy before receiving intervention according to their group assignment. The outcomes were measured at four points: baseline, after placebo …

The Role Of Interleukin-6 (Il-6) On Osteogenic Differentiation Potential Of Human Periodontal Ligament Stem Cells (Hpdlscs) In Vitro, Medania Purwaningrum

Chulalongkorn University Theses and Dissertations (Chula ETD)

Interleukin-6 (IL-6) has been reported significantly increases in inflammation environment and plays pivotal roles in osteogenic differentiation and matrix mineralization enhancement. However, the regulating pathways governing osteogenic differentiation potential by human periodontal ligament stem cells (hPDLSCs) under IL-6 treatment are still unclear. To elucidate this phenomenon, the pathway inhibiton and stimulation strategies were employed. Osteogenic and pathway-related mRNA marker expression, alkaline phosphatase (ALP) activity, matrix mineralization, and b-catenin stabilization and translocation were analyzed. The results showed that IL-6 significantly enhanced osteogenic differentiation in terms of osteogenic marker expression, ALP activity, and matrix mineralization mainly via canonical and non-canonical Wnt pathways …

Plasmodium Bubalis; The Development Of An Effective Detection Method, The Course Of Infection, Co-Infection, Multi-Gene Phylogeny, And The Potential Vector, Yudhi Ratna Nugraheni

Chulalongkorn University Theses and Dissertations (Chula ETD)

Ungulate malaria parasites, such as the species that infects farmed dairy buffaloes (Plasmodium bubalis), have received little attention, with only a few reports in other livestock animals. Therefore, a comprehensive understanding of the parasites, hosts, and mosquito vectors for their biology and molecular evolution remains inadequate. This study aimed to investigate the natural infection of P. bubalis and its suspected vector, develop an effective detection method, and analyze the genome of P. bubalis and related genera. A total of 177 buffaloes’ blood samples were collected from 2019 to 2021 to evaluate the malaria infection status. Mosquitoes were also collected (1,652 …

Minimal Inhibitory And Mutant Prevention Concentrations Of Levofloxacinagainst Gram-Negative Canine Urinary Pathogenic Bacteria, Thanawit Siha-Umphai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Levofloxacin (LEV) is one of the third-generation quinolones with broader spectrum against gram-positive and anaerobic bacteria, compared with the previous generations. LEV is an extra-label antimicrobial drug for treating systemic infection and urinary tract infection (UTI) in dogs in many countries including Thailand. Although the pharmacokinetic data of LEV in dogs has been published, its antimicrobial activity against gram-negative bacteria causing UTI is limited. The aim of this study was to investigate the antimicrobial activities of LEV against canine gram-negative urinary pathogenic bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis and Pseudomonas aeruginosa. These gram-negative bacteria were retrieved from dogs …

(Un)Masking The Truth - The Cruel And Unusual Punishment Of Prisoners Amidst The Covid-19 Pandemic, Ariel Berkowitz

Touro Law Review

No abstract provided.

Vaccination And The Child’S Right To An Open Future, Elias Feldman

Lewis & Clark Law Review

States commonly require the vaccination of children through their parens pa- triae and police powers. But many states also allow parents to opt for non- medical exemptions from these vaccination requirements, contributing to the emergence of a national vaccine hesitancy crisis. By permitting parents not to vaccinate their children, do states that grant these exemptions violate children’s rights? This Article posits that children may indeed have a right to be vac- cinated and thus protected against contracting a disease for which there is a scientifically proven vaccine. This Article examines this question through the lens of Joel Feinberg’s theory of …

Tick Ecdysteroid Hormone, Global Microbiota/Rickettsia Signaling In The Ovary Versus Carcass During Vitellogenesis In Part-Fed (Virgin) American Dog Ticks, Dermacentor Variabilis, Loganathan Ponnusamy, Haley Sutton, Robert D. Mitchell Iii, Daniel E. Sonenshine, Charles S. Apperson, Richard Michael Roe

Biological Sciences Faculty Publications

The transovarial transmission of tick-borne bacterial pathogens is an important mechanism for their maintenance in natural populations and transmission, causing disease in humans and animals. The mechanism for this transmission and the possible role of tick hormones facilitating this process have never been studied. Injections of physiological levels of the tick hormone, 20-hydroxyecdysone (20E), into part-fed (virgin) adult females of the American dog tick, Dermacentor variabilis, attached to the host caused a reduction in density of Rickettsia montanensis in the carcass and an increase in the ovaries compared to buffer-injected controls. This injection initiates yolk protein synthesis and uptake …

J Mich Dent Assoc January 2021

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

In this issue, the reader will find the following original content:

• A cover story on “The Dentist’s Role in Recognizing Sleep-Disordered Breathing in Children”.
• A feature article, “Dental Sleep Medicine Education: Do You Want a Nap or a Full Night’s Sleep?”.
• The feature article, “In-office Plans: Where Are We Now? What Have We Learned?”
• News you need, Editorial and regular department articles on MDA Foundation activities, …

Adolescent Medical Decisionmaking Rights: Reconciling Medicine And Law, Doriane Lambelet Coleman, Philip M. Rosoff

Faculty Scholarship

Dennis Lindberg came into his aunt’s care when he was in the 4th grade because his parents struggled with drug addiction and could not provide for him. At thirteen, he was baptized in his aunt’s faith as a Jehovah’s Witness. Just days after he turned fourteen, on November 6, he was diagnosed with acute lymphoblastic leukemia.

The prognosis was that Dennis had a 75% chance of cure with standard oncology treatment. Consistent with the requirements of his new faith, however, Dennis told his doctors, “I do not want to be treated if the requirement is that I would have to …

History Of The Department Of Pathology And Immunology And Its Divisions, Washington University School Of Medicine., Jack H. Ladenson Phd

Washington University School of Medicine Histories

No abstract provided.

World Leaders Join Forces To Fight The Accelerating Crisis Of Antimicrobial Resistance

Neurosciences

No abstract provided.

World Leaders Join Forces To Fight The Accelerating Crisis Of Antimicrobial Resistance

Neurosciences

No abstract provided.

A Pathway To Health Care Citizenship For Daca Beneficiaries, Medha D. Makhlouf, Patrick J. Glen

Faculty Scholarly Works

Since 2012, beneficiaries of Deferred Action for Childhood Arrivals (DACA) have enjoyed a certain normalization, however tenuous, of their status in the United States: they can legally work, their removal proceedings are deferred, and they cease to accrue unlawful presence. Regarding subsidized health coverage, however, DACA beneficiaries remain on the outside looking in. Although other deferred action beneficiaries are eligible for benefits through Medicaid, the Children’s Health Insurance Program, and the Affordable Care Act, the Obama Administration specifically excluded DACA beneficiaries. This decision undermines DACA’s goal of legitimizing beneficiaries’ presence in the United States. From a health policy perspective, it …

Constitutional Pandemic Surveillance, Matthew B. Kugler, Mariana Oliver

Journal of Criminal Law and Criminology

How do people view governmental pandemic surveillance? And how can their views inform courts considering the constitutionality of digital monitoring programs aimed at containing the spread of a highly contagious diseases? We measure the perceived intrusiveness of pandemic surveillance through two nationally representative surveys of Americans. Our results show that even at the height of a pandemic people find surveillance for public health to be more intrusive than surveillance for traditional law enforcement purposes. To account for these strong privacy concerns, we propose safeguards that we believe would make cell phone location tracking and other similar digital monitoring regimes constitutionally …

Etsu Health Annual Report - 2021, 2021

ETSU Health Annual Reports

No abstract provided.

Novel Machine Learning And Wearable Sensor Based Solutions For Smart Healthcare Monitoring, Rajdeep Kumar Nath

Theses and Dissertations--Electrical and Computer Engineering

The advent of IoT has enabled the design of connected and integrated smart health monitoring systems. These health monitoring systems can be utilized for monitoring the mental and physical wellbeing of a person. Stress, anxiety, and hypertension are the major elements responsible for the plethora of physical and mental illnesses. In this context, the older population demands special attention because of the several age-related complications that exacerbate the effects of stress, anxiety, and hypertension. Monitoring stress, anxiety, and blood pressure regularly can prevent long-term damage by initiating necessary intervention or clinical treatment beforehand. This will improve the quality of life …

Chronology Of The Fatherland Site, Daniel Shawl

Electronic Theses and Dissertations

A recently discovered mound (Mound E) at the Grand Village of the Natchez Indians (22AD501, the Fatherland Site) dates to the Foster phase of the Mississippian period (1300-1500 CE). This new chronology is stems from analysis conducted on ceramic assemblages from Robert S. Neitzel’s (1965) excavations and ceramic assemblages from Tony Boudreaux’s (2019) excavations at the site. Frequency seriations, non-metric multidimensional scaling, and radiocarbon dates suggest that Mound E was constructed and in use several hundred years prior to European contact at the site. The results of this body of research brings new insight into a portion of history of …

Laser-Scribed Graphene Electrodes As Inflammatory Biosensors (Laserflame), Pei Shee Tan

Theses

Laser-scribed graphene electrodes (LSGE) are a low cost, portable, flexible and ideal electrochemical platform approach as point of care biosensors. It is anticipated that integrating the detection of immune cell inflammatory cytokines with LSGEs may present a useful diagnostic platform for managing the risk of inflammatory diseases as early detection of inflammatory molecules could significantly improve the treatment and outcome of diseases induced by protracted inflammation, such as cancer, asthma and rheumatoid arthritis. This study proposed LSGE first time novel use in the detection of an inflammatory cytokine released by immune cells (monocyte THP-1 cell line), with high sensitivity and …

Gender Parity In Science: The Intersection Of The National Education Policy 2020 And The Draft Science, Technology, And Innovation Policy, Jyoti Sharma

Teacher India

With International Women’s Day observed on 8 March, Jyoti Sharma’s review of the National Education Policy 2020 and the draft Science, Technology, and Innovation Policy through the lens of gender parity is a timely reminder of the need to support improved participation of women in science.