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Etsu Health Annual Report - 2021, 2021

ETSU Health Annual Reports

No abstract provided.

Novel Machine Learning And Wearable Sensor Based Solutions For Smart Healthcare Monitoring, Rajdeep Kumar Nath

Theses and Dissertations--Electrical and Computer Engineering

The advent of IoT has enabled the design of connected and integrated smart health monitoring systems. These health monitoring systems can be utilized for monitoring the mental and physical wellbeing of a person. Stress, anxiety, and hypertension are the major elements responsible for the plethora of physical and mental illnesses. In this context, the older population demands special attention because of the several age-related complications that exacerbate the effects of stress, anxiety, and hypertension. Monitoring stress, anxiety, and blood pressure regularly can prevent long-term damage by initiating necessary intervention or clinical treatment beforehand. This will improve the quality of life …

Chronology Of The Fatherland Site, Daniel Shawl

Electronic Theses and Dissertations

A recently discovered mound (Mound E) at the Grand Village of the Natchez Indians (22AD501, the Fatherland Site) dates to the Foster phase of the Mississippian period (1300-1500 CE). This new chronology is stems from analysis conducted on ceramic assemblages from Robert S. Neitzel’s (1965) excavations and ceramic assemblages from Tony Boudreaux’s (2019) excavations at the site. Frequency seriations, non-metric multidimensional scaling, and radiocarbon dates suggest that Mound E was constructed and in use several hundred years prior to European contact at the site. The results of this body of research brings new insight into a portion of history of …

Laser-Scribed Graphene Electrodes As Inflammatory Biosensors (Laserflame), Pei Shee Tan

Theses

Laser-scribed graphene electrodes (LSGE) are a low cost, portable, flexible and ideal electrochemical platform approach as point of care biosensors. It is anticipated that integrating the detection of immune cell inflammatory cytokines with LSGEs may present a useful diagnostic platform for managing the risk of inflammatory diseases as early detection of inflammatory molecules could significantly improve the treatment and outcome of diseases induced by protracted inflammation, such as cancer, asthma and rheumatoid arthritis. This study proposed LSGE first time novel use in the detection of an inflammatory cytokine released by immune cells (monocyte THP-1 cell line), with high sensitivity and …

Gender Parity In Science: The Intersection Of The National Education Policy 2020 And The Draft Science, Technology, And Innovation Policy, Jyoti Sharma

Teacher India

With International Women’s Day observed on 8 March, Jyoti Sharma’s review of the National Education Policy 2020 and the draft Science, Technology, and Innovation Policy through the lens of gender parity is a timely reminder of the need to support improved participation of women in science.

What Pandemic?: Physical Memorialization Of The 1918 Pandemic, Carly M. Kauffman

Master's Theses or Doctor of Nursing Practice

Throughout history there have been many significant events the people find worth remembering. Some of these events are significant enough that people build structures to honor, commemorate, or memorialize them. However, there are some events that are also significant, yet they seem to warrant little or no memorialization. In the United States' historical narrative, it seems that the Influenza Pandemic of 1918 is forgotten among the chaotic period of World War I and the interwar years. The lack of traditional memorials dedicated to the 1918 Pandemic can be attributed to the lack of acknowledgement of the pandemic in terms of …

Less Common Bacterial, Fungal And Viral Infections: Review Of Management In The Pregnant Patient, Alyssa P. Gould, Hana R. Winders, Kayla R. Stover, P Brandon Bookstaver, Brooke Griffin, Christopher M. Bland, Lea S. Eiland, Milena Murray

Faculty Publications

This review is a comprehensive summary of treatment options for pregnant patients with less common bacterial, fungal, and viral infections. It offers guidance to clinicians based on the most recently published evidence-based research and expert recommendations. A search of MEDLINE (inception to March 2021) and the CDC website was performed. Liposomal amphotericin B is the preferred therapy for cryptococcosis, histoplasmosis, oesophageal candidiasis, and coccidioidomycosis, especially during the first trimester due to teratogenic concerns with azole antifungals. For oral candidiasis, clotrimazole troches or miconazole mucoadhesive buccal tablets are recommended. A β-lactam antimicrobial is preferred over doxycycline for various manifestations of Lyme …

Il-10 And Tgf-Beta Increase Connexin-43 Expression And Membrane Potential Of Hl-1 Cardiomyocytes Coupled With Raw 264.7 Macrophages, Cora B. Cox

Browse all Theses and Dissertations

Cardiomyocytes and macrophages have been found to interact via connexin-43 hemichannels. The role of connexin-43, however, is not fully understood. This study shows that these interactions aid in increasing the membrane potential of cardiomyocytes allowing contraction of the cells. HL-1 cardiomyocytes and RAW 264.7 macrophages in coculture increased expression of connexin-43 compared to cardiomyocytes alone. Co-cultures also increased the fluorescence of Di-8-ANEPPS potentiometric dye indicating an increase in cardiomyocyte membrane potential. Treatment with IL-10 and TGF-beta further increased connexin-43 expression and membrane potential. Treatment with SOCS3 inhibited the effects of TGF-beta and IL-10 while having no effect on its own. …

Effectiveness Of An Educational Intervention To Reduce Ageism In Undergraduate Students In An Entry-Level Nutrition Class, Ann Irvin Armstrong

Electronic Theses and Dissertations

Although the older adult population continues to increase, ageism remains an issue in the healthcare system and is prevalent among nutrition-related professionals. The aim of our study is to is determine the effectiveness of an educational intervention to reduce ageism among pre-healthcare professionals including Nutrition major students. Undergraduate students enrolled in an entry-level nutrition class were recruited and randomized into an intervention (INT) group (n=30) and a control (CON) group (n=29). The online educational intervention consisted of pre-recorded lectures and videos regarding ageism and myths regarding aging for the INT group, and on cultural competency and biases (other than ageism) …

Subcutaneous Delivery Of Albumin, Vy Nguyen

Electronic Theses and Dissertations

An increasing number of protein drugs are used in the clinic to treat a broad range of diseases. However, because of their large molecular sizes and high hydrophilicity, protein drugs are not orally bioavailable, which commonly require intravenous, intramuscular or subcutaneous injection. Thermosensitive polymers have been widely investigated as in situ depots for sustained drug release delivered through subcutaneous route.Albumin is the most abundant proteins in bloodstream. It has long half-life (19 days in human) and plays important roles such as acting as carrier for fatty acids, amino acids, waste products and medical compounds. Albumin has been studied for decades …

Applications Of Fluoronitroalkenes In 1,3-Dipolar Cycloaddition And 1,4-Conjugate Addition, Hamdan Eid Alrefaei

Electronic Theses and Dissertations

Fluorinated compounds have been routinely synthesized in the pharmaceutical and agricultural industries. Approximately, 45% of drugs approved by the U.S. Food and Drug Administration in 2018−2019, and 52% of agricultural products between 2010 and 2017 were fluorinated compounds. In comparison to their non-fluorinated counterparts, fluorinated drugs have different pharmacokinetics and pharmacodynamics profiles. Bond strength and electronegativity of the fluorine atom can affect the compound's pKa, dipole moment, and metabolic stability. Therefore, methods to access fluorinated compounds are highly pursued in organic synthesis. Various fluorinating agents (nucleophilic and electrophilic) have been developed over the last few decades and are widely employed …

Prevalence And Correlates Of Secondary Syringe Exchange (Sse) Among People Who Inject Drugs (Pwid) In Rural Kentucky, Jordan R. Wilson

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Aim: To describe the prevalence of secondary syringe exchange (SSE) in a sample of syringe service program (SSP) clients in rural Appalachian Kentucky and to identify the correlates of SSE.

Methods: Participants (n=338) completed interviewer-administered questionnaires. Only those who reported having ever exchanged syringes at a SSP (n=140) were included in analysis. SSE was measured through self-report of obtaining syringes for someone else at a SSP in the past 6 months. Prevalence and correlates of SSE were examined using bivariate analysis and multiple logistic regression.

Results: Overall, 30% of participants reported SSE. Participants in the second [aOR= 3.83; 95% CI: …

Impact Of Smoking And Hpv Status On Cervical Cancer Survival In Women Living In Kentucky, 2004-2005 And 2014-2015, Brittany M. Mckinley

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

BACKGROUND/ OBJECTIVE: Cervical cancer is the fourth most commonly occurring malignancy in women worldwide, with an estimated 530,000 new cases and 270,000 new deaths each year (Small et al, 2017). While the incidence of cervical cancer has decreased by approximately 1.9% per year between 2007 and 2011, the death rate has remained stable (Bernard et al, 2014). Studies have shown that nearly all cervical cancer cases are associated with the Human Papilloma Virus (HPV). Many studies support the association of smoking with increased risk of invasive cervical cancer in women with high-risk HPV (Castle et al, 2002; Fang et al, …

Methenamine Prophylaxis For Recurrent Urinary Tract Infections In A Tertiary Referral Center, Cameron A. Wade

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Purpose: Methenamine hippurate (MH) is a urinary antiseptic, indicated for prophylaxis of recurrent urinary tract infections (UTIs) but with only few and limited studies regarding its efficacy. To help address this knowledge gap we reviewed our experience with MH for UTI prophylaxis, focusing on women with recurrent uncomplicated UTIs.

Materials and Methods: The University of Kentucky electronic health record was queried to identify adults who were prescribed MH from the Urology clinic between January 2013 and January 2019. Charts were reviewed to assess patient-reported UTI frequency, demographics and relevant health factors. Treatment success was defined as 0-1 UTI in 6 …

Healthy Living People: A Hiv Transmission Intervention In Four Chicago Communities, Angela Wuerger

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The transmission of HIV within the city of Chicago has been established as a major health concern: however, the lack of adequate resources has created gaps within current programming available for people living with HIV. Healthy Living People (HLP) is an evidence-based program focused on reducing the transmission of HIV through strengthening adherence to antiretroviral therapy and decreasing number of higher risk sexual encounters. The Chicago Department of Public Health will provide the HLP program, which includes fifteen 90-minute sessions over the course of one year. The HLP program will be offered for people living with

HIV in four Chicago …

Rabies In Kentucky From 1989-2020: A Case For Surveillance, Sarah Jane Robbins

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The Kentucky rabies reporting system includes data from five laboratories and provides an account of suspected rabies reports since 1989. Over 35,000 suspected cases are used to estimate rabies incidence temporally and spatially. Recommendations to the current rabies reporting methodologies are presented through proposed innovations of a standard, electronic reporting form. Given the multiple sources of data, the reporting system lacks standardization and comprehensive information about suspected rabies events, resulting in limited epidemiological capabilities; and data issues that prevent its use as a surveillance system. These issues are a limiting factor in rabies elimination; but a driving factor in over-testing, …

Mitigating Opioid Related Healthcare Use In Kentucky: An Assessment Of The Impact Of Kentucky Revised Statute (Krs) Changes To Opioid Prescribing On Opioid Related Prescribing And Healthcare Utilization, Drew Speer

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The opioid epidemic has impacted few other places more than the state of Kentucky. In 2018, data from the Centers of Disease Control and Prevention (CDC) and the National Institute on Drug Abuse (NIDA) ranked Kentucky as being in the top ten for rate of drug overdose deaths and opioid-involved overdose deaths per 100,000 persons.^1,2 These rankings exist even though prescription opioid dispensing rates have fallen from 102.6 per 100 persons in 2015 to 72.3 per 100 persons in 2019.³ Aligning with this trend, while research shows this problem began with prescription opioids in the late 1990’s, it …

What Do Patients Use For Treating Their Oral Ulcers? And How Do These Treatments Affect Their Quality Of Life?, Enji Ahmed Mahmoud, Ayat Gamal Abdel-Nasser, Mai Zakaria, Sohair Gaafar

Dentistry

Objectives: Oral ulceration forms a major category of oral lesions. Due to its effect on the quality of life, the patients seek treatment using various substances. This study investigated the types of treatments used by a sample of patients having all types of oral ulcers and its positive and negative effects on the patients' lives. Methods: This cross-sectional study included patients having different types of oral ulcers. Participants provided information about their previous treatments, the source of recommendation of its use and side effects linked to them. They filled the oral health impact profile-14 questionnaire to report the change in …

Assessing Factors That Increase The Likelihood Of Naloxone Administration, Samantha Nagy

PCOM Psychology Dissertations

For more than two decades, the opioid epidemic has swept through the United States and has caused thousands of deaths every year due to opioid overdose. The Centers for Disease Control and Prevention (CDC; 2019) has reported that since 1999, over 770,000 Americans have died from overdoses. Nearly 70% of deaths in 2018 were due to opioids, 47% of which were the result of fentanyl or a non-methadone opioid and 22% were the result of heroin (CDC, 2019). As policy and treatment protocols attempt to manage those who seek treatment, the pharmaceutical industry has developed a life-saving medication that gives …

Occupational Health Practices Among Dental Care Professionals Before And During The Covid-19 Pandemic, Sean Banaee, Denise M. Claiborne, Muge Akpinar-Elci

Community & Environmental Health Faculty Publications

BACKGROUND: The COVID-19 pandemic has posed a substantial burden on dental care professionals. While dentistry is known as one of the most exposed and high-risk professions, dental care professionals are indeed at even greater risk.

OBJECTIVE: The aim of this study was to assess knowledge, attitudes, occupational health practices, personal protective equipment usage, and mental stressors during COVID-19 pandemic among dental care professionals.

METHODS: A cross-sectional study was conducted among dental care professionals who were subscribers to a dental hygiene journal using a self-administered online survey (n = 1047 respondents). Cross-tabulations were performed to determine differences in the responses to …

Trends And Opportunities In Tick-Borne Disease Geography, Catherine A. Lippi, Sadie J. Ryan, Alexis L. White, Holly D. Gaff, Colin J. Carlson

Biological Sciences Faculty Publications

Tick-borne diseases are a growing problem in many parts of the world, and their surveillance and control touch on challenging issues in medical entomology, agricultural health, veterinary medicine, and biosecurity. Spatial approaches can be used to synthesize the data generated by integrative One Health surveillance systems, and help stakeholders, managers, and medical geographers understand the current and future distribution of risk. Here, we performed a systematic review of over 8,000 studies and identified a total of 303 scientific publications that map tick-borne diseases using data on vectors, pathogens, and hosts (including wildlife, livestock, and human cases). We find that the …

Antibodies Against Egf-Like Domains In Ixodes Scapularis Bm86 Orthologs Impact Tick Feeding And Survival Of Borrelia Burgdorferi, Juraj Koči, Sandhya Bista, Payal Chirania, Xiuli Yang, Chrysoula Kitsou, Vipin Singh Rana, Ozlem Buyuktanir Yas, Daniel E. Sonenshine, Utpal Pal

Biological Sciences Faculty Publications

Ixodes scapularis ticks transmit multiple pathogens, including Borrelia burgdorferi sensu stricto, and encode many proteins harboring epidermal growth factor (EGF)-like domains. We show that I. scapularis produces multiple orthologs for Bm86, a widely studied tick gut protein considered as a target of an anti-tick vaccine, herein termed as Is86. We show that Is86 antigens feature at least three identifiable regions harboring EGF-like domains (termed as EGF-1, EGF-2, and EGF-3) and are differentially upregulated during B. burgdorferi infection. Although the RNA interference-mediated knockdown of Is86 genes did not show any influences on tick engorgement or B. burgdorferi sensu stricto persistence, the …

Income-Related Health Inequality Among Chinese Adults During The Covid-19 Pandemic: Evidence Based On An Online Survey, Peng Nie, Lanlin Ding, Zhou Chen, Shiyong Liu, Qi Zhang, Zumin Shi, Lu Wang, Hong Xue, Gordon G. Liu, Youfa Wang

Community & Environmental Health Faculty Publications

BACKGROUND: Partial- or full-lockdowns, among other interventions during the COVID-19 pandemic, may disproportionally affect people (their behaviors and health outcomes) with lower socioeconomic status (SES). This study examines income-related health inequalities and their main contributors in China during the pandemic.

METHODS: The 2020 China COVID-19 Survey is an anonymous 74-item survey administered via social media in China. A national sample of 10,545 adults in all 31 provinces, municipalities, and autonomous regions in mainland China provided comprehensive data on sociodemographic characteristics, awareness and attitudes towards COVID-19, lifestyle factors, and health outcomes during the lockdown. Of them, 8448 subjects provided data for …

Trust And Public Health Emergency Events: A Mixed-Methods Systematic Review, Pradeep Sopory, Julie Novak, Ashleigh M. Day, Stine Eckert, Lee Wilkins, Donyale R. Padgett, Jane P. Noyes, Tomas Allen, Nyka Alexander, Marsha L. Vanderford, Gaya M. Gamhewage

Communication Faculty Publications and Presentations

The systematic review examined the phenomenon of trust during public health emergency events. The literature reviewed was field studies done with people directly affected or likely to be affected by such events and included quantitative, qualitative, mixed-method, and case study primary studies in English (N = 38) as well as Arabic, Chinese, French, Russian, and Spanish (all non-English N = 30). Studies were mostly from high-and middle-income countries, and the event most covered was infectious disease. Findings from individual studies were first synthesized within methods and evaluated for certainty/confidence, and then synthesized across methods. The final set of 11 findings …

Internet Memes: Leaflet Propaganda Of The Digital Age, Joshua Troy Nieubuurt

English Faculty Publications

Internet memes are one of the latest evolutions of “leaflet” propaganda and an effective tool in the arsenal of digital persuasion. In the past such items were dropped from planes, now they find their way into social media across multiple platforms and their territory is global. Internet memes can be used to target specific groups to help build and solidify tribal bonds. Due to the ease of creation, and their ability to constantly reaffirm axiomatic tribal ideas, they have become an adroit tool allowing for mass influence across international borders. This text explores the link between internet memes and their …

Biology And Molecular Biology Of Ixodes Scapularis, Daniel E. Sonenshine, Ladislav Šimo, Justin D. Radolf (Ed.), D. Scott Samuels (Ed.)

Biological Sciences Faculty Publications

This chapter describes the biology of the tick Ixodes scapularis in relation to its role as the vector of the Lyme disease agent, Borrelia burgdorferi. Following a review of the internal anatomy of the tick, we review basic molecular processes that contribute to an understanding of the dynamics of the tick's specialized parasitic processes, including attachment behavior, salivation; silencing of host anti-inflammatory responses to enable blood ingestion at the dermal feeding site; hemoglobin digestion and reproduction. The chapter is divided into three parts: 1) systematic and anatomical characteristics of ticks; 2) host finding, attachment, salivary disruption of host defenses, blood …

Scoping Review Of Distribution Models For Selected Amblyomma Ticks And Rickettsial Group Pathogens, Catherine A. Lippi, Holly D. Gaff, Alexis L. White, Sadie J. Ryan

Biological Sciences Faculty Publications

The rising prevalence of tick-borne diseases in humans in recent decades has called attention to the need for more information on geographic risk for public health planning. Species distribution models (SDMs) are an increasingly utilized method of constructing potential geographic ranges. There are many knowledge gaps in our understanding of risk of exposure to tick-borne pathogens, particularly for those in the rickettsial group. Here, we conducted a systematic scoping review of the SDM literature for rickettsial pathogens and tick vectors in the genus Amblyomma. Of the 174 reviewed articles, only 24 studies used SDMs to estimate the potential extent …

Double Anus In An Ixodes Scapularis Nymph, A Medically Important Tick Vector, Vikas Taank, Frank A. Lattanzio, Hameeda Sultana, Girish Neelakanta

Biological Sciences Faculty Publications

Background: Ixodes scapularis ticks are medically important arthropod vectors that transmit several pathogens to humans. The observations of morphological abnormalities, including nanism, missing leg, extra leg, and gynandromorphism, have been reported in these ticks. In this study, we report the presence of two anuses in a laboratory-reared I. scapularis nymph.

Results: Larval ticks were allowed to feed on mice and to molt to nymphs. Two anuses were observed in one of the freshly molted nymphs. Stereo and scanning electron microscopy confirmed the presence of two anuses in one nymph within a single anal groove.

Conclusions: This report confirms the rare …

Building Emotionally Resilient Schools And Educators During Crises, Corinne Brion

Educational Leadership Faculty Publications

Teaching is one of the most stressful occupations in the U.S (Gallup, 2014). Stress affects teachers’ health and well-being, job satisfaction, job turnover, and student outcomes (Greenberg et al., 2016). Possessing and using social and emotional skills is necessary to regulate stress, maintain healthy personal and professional lives, and thrive as teachers and leaders (Jennings & Greenberg, 2009; Jennings, 2015). Social Emotional Learning (SEL) is key to human development because it is “the process through which all young people and adults acquire and apply the knowledge, skills, and attitudes to develop healthy identities, manage emotions and achieve personal and collective …

2021 Icrcc Proceedings Table Of Contents, Conference Organizers

International Crisis and Risk Communication Conference

These proceedings are a representative sample of the presentations given by professional practitioners and academic scholars at the 2021 International Crisis and Risk Communication Conference (ICRCC) held virtually March 8-10, 2021. The goal of the ICRCC is to bring together prominent professional risk and crisis communication practitioners and academic scholars from around the world to spend a few days networking and engaging in conversation about issues and problems related to risk and crisis communication in a variety of contexts (e.g., natural disasters, political crises, food safety issues, biosecurity, health epidemics and pandemics).