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Articles 4501 - 4530 of 5583
Full-Text Articles in Entire DC Network
Analysis Of Designs Used In Monitoring Crop Growth Based On Remote Sensing Methods, Cristina Teodora Dobrota, Rahela Carpa, Anca Butiuc-Keul
Analysis Of Designs Used In Monitoring Crop Growth Based On Remote Sensing Methods, Cristina Teodora Dobrota, Rahela Carpa, Anca Butiuc-Keul
Turkish Journal of Agriculture and Forestry
Choosing appropriate designs and methods for monitoring crop growth is a challenging process of major importance. Remote sensing from space and manned or unmanned airborne operations are used to measure crop reflectance and a wide variety of other agricultural parameters. While some experiments use only a few, specific methods and designs and organize the results in lists of evidence, other experiments use a wider range of techniques to create a more credible and comprehensive assessment of crop yield. Particular situations related to the available resources in terms of data collection and expertise in addition to the intended use of the …
An Example Of Risk Management On Board A Cruise Ship : Covid-19, Katsuya Matsui, Nobuaki Nakamura
An Example Of Risk Management On Board A Cruise Ship : Covid-19, Katsuya Matsui, Nobuaki Nakamura
International Maritime Lecturers' Association (IMLA) 2021 Joint Conference With IMEC32, ICERS15 and INSLC21
The COVID-19 outbreak in 2020 is still giving impacts to world economy and crisis management system. My cruise ship sailed from Yokohama in Jan 17 2020 to round Asian Cruise with 300 aged passengers and 200 crews under beginning of emergency situation. As a reference of crisis management and human behaviour, designated in STCW convention STCW section V/2 par. 3-4 and is based on the guidelines of IMO Model Course 1.29, I introduce my experience featuring leadership of crisis management of anti-infectious disease of COVID 19 as a captain of cruise ship. The objective of this paper is to suggest …
Dengue And The Lectin Pathway Of The Complement System, Romchat Kraivong, Nuntaya Punyadee, M Kathryn Liszewski, John P Atkinson, Panisadee Avirutnan
Dengue And The Lectin Pathway Of The Complement System, Romchat Kraivong, Nuntaya Punyadee, M Kathryn Liszewski, John P Atkinson, Panisadee Avirutnan
Open Access Publications
Dengue is a mosquito-borne viral disease causing significant health and economic burdens globally. The dengue virus (DENV) comprises four serotypes (DENV1-4). Usually, the primary infection is asymptomatic or causes mild dengue fever (DF), while secondary infections with a different serotype increase the risk of severe dengue disease (dengue hemorrhagic fever, DHF). Complement system activation induces inflammation and tissue injury, contributing to disease pathogenesis. However, in asymptomatic or primary infections, protective immunity largely results from the complement system's lectin pathway (LP), which is activated through foreign glycan recognition. Differences in N-glycans displayed on the DENV envelope membrane influence the lectin pattern …
Il-7 Immunotherapy In A Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis, Isaiah R. Turnbull, Monty B. Mazer, Mark H. Hoofnagle, John P. Kirby, Jennifer M. Leonard, Carlos Mejia-Chew, Andrej Spec, Jane Blood, Sydney M. Miles, Eric M. Ransom, Robert F. Potter, Joseph P. Gaut, Kenneth E. Remy, Richard S. Hotchkiss
Il-7 Immunotherapy In A Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis, Isaiah R. Turnbull, Monty B. Mazer, Mark H. Hoofnagle, John P. Kirby, Jennifer M. Leonard, Carlos Mejia-Chew, Andrej Spec, Jane Blood, Sydney M. Miles, Eric M. Ransom, Robert F. Potter, Joseph P. Gaut, Kenneth E. Remy, Richard S. Hotchkiss
Open Access Publications
A nonimmunocompromised patient developed life-threatening soft tissue infection with
Evaluation Of Commercial Rapid Lateral Flow Tests, Alone Or In Combination, For Sars-Cov-2 Antibody Testing, Peter U Fischer, Kerstin Fischer, Kurt C Curtis, Yuefang Huang, Nicole Fetcho, Charles W Goss, Gary J Weil
Evaluation Of Commercial Rapid Lateral Flow Tests, Alone Or In Combination, For Sars-Cov-2 Antibody Testing, Peter U Fischer, Kerstin Fischer, Kurt C Curtis, Yuefang Huang, Nicole Fetcho, Charles W Goss, Gary J Weil
Open Access Publications
Antibody tests can be tools for detecting current or past severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 [coronavirus disease 2019 (COVID-19)]) infections. Independent test evaluations are needed to document the performance with different sample sets. We evaluated six lateral flow assays (LFAs) and two laboratory-based tests (EUROIMMUN-SARS-CoV-2 ELISA and Abbott-Architect-SARS-CoV-2-IgG). We tested 210 plasma samples from 89 patients diagnosed with acute COVID-19. These samples were collected at different time points after the onset of symptoms. In addition, 80 convalescent plasma samples, and 168 pre-pandemic samples collected from adults in the United States and in Africa were tested. LFA performance varied …
Female And Male-Controlled Livestock Holdings Impact Pastoralist Food Security And Women’S Dietary Diversity, Henriette Gitungwa, Christopher Gustafson, E.Y. Jimenez, E. Wesley F. Peterson, M. Mwanzalila, Asha Makweta, E. Komba, R.R. Kazwala, J.A.K. Mazet, Elizabeth Vanwormer
Female And Male-Controlled Livestock Holdings Impact Pastoralist Food Security And Women’S Dietary Diversity, Henriette Gitungwa, Christopher Gustafson, E.Y. Jimenez, E. Wesley F. Peterson, M. Mwanzalila, Asha Makweta, E. Komba, R.R. Kazwala, J.A.K. Mazet, Elizabeth Vanwormer
School of Veterinary and Biomedical Sciences: Faculty Publications
Background: Food insecurity is a global problem that requires a One Health approach. As many households in low- and middle-income nations rely on crops and livestock that they produce to meet their household’s needs, food security and nutrition are closely linked to the health of animals and the environment. Resources controlled by women are more often allocated to uses that benefit the entire household, such as food, health, and educating children, than men’s resources. However, studies of gender control of resources among pastoralist societies are scant. We examined the effect of female and male control of livestock resources on food …
Fear Of Zika: Information Seeking As Cause And Consequence, James Price Dillard, Ruobing Li, Chun Yang
Fear Of Zika: Information Seeking As Cause And Consequence, James Price Dillard, Ruobing Li, Chun Yang
Faculty Publications
This study examined the relationship between information seeking and fear during the Zika-induced global health crisis. A longitudinal survey of women in the Southern U.S. (N = 306) was conducted in 2016, beginning just days after the World Health Organization declared Zika a global crisis. The data showed that time 1 fear stimulated information seeking at time 2 and that time 2 information seeking caused fear at time 3. This pattern held regardless of whether participants were pregnant or planning to become pregnant (high personal relevance) versus neither (low personal relevance). The findings are at odds with most theories of …
Workplace Experiences Of Migrant Workers In Colorado, Lynann Holly Butler
Workplace Experiences Of Migrant Workers In Colorado, Lynann Holly Butler
Walden Dissertations and Doctoral Studies
AbstractMigrant workers often endure a variety of abuses in the workplace, including financial exploitation, exposure to toxins, isolation, and lack of access to health care. Although researchers have demonstrated that these circumstances exist for migrant workers in other parts of the world, there was a dearth of research on the lived experiences of migrant workers in Colorado. The purpose of this hermeneutic phenomenological study was to better understand the lived experiences of migrant workers in Colorado, who are a growing and impactful population in Colorado. The theoretical framework was Rawl’s social justice theory, which purports that no one group of …
Responses Of Myxobacteria To Plant-Related Chemosignals Suggests Their Roles In The Rhizobiome, Barbara Iyare Adaikpoh
Responses Of Myxobacteria To Plant-Related Chemosignals Suggests Their Roles In The Rhizobiome, Barbara Iyare Adaikpoh
Electronic Theses and Dissertations
In the rhizosphere, plants curate and maintain distinct rhizobiome, some of which serve as secondary defense mechanisms against pathogenic microorganisms. Additionally, in response to biotic stress, plants generate phytohormones which regulate signaling pathways to activate systemic resistance. These phytohormones contribute to the chemical space within the rhizosphere in addition to other low-molecular-weight metabolites used for cell-to-cell communication within species and across kingdoms. However, little is known about the influences of stress-related phytohormones on beneficial bacteria even though biocontrol strategies abundantly explore plant-beneficial microorganisms to manage pathogens in agricultural systems. Myxobacteria are competent predators of plant pathogens and have demonstrated responses …
Four Futures For U.S. Pandemic Policy, Daniel J. Hemel
Four Futures For U.S. Pandemic Policy, Daniel J. Hemel
Faculty Articles
The COVID-19 pandemic is probably not the last time that a new and deadly infectious disease will sweep the planet. What can the United States do to improve its chances of averting large-scale loss of life the next time? This essay—prepared for The University of Chicago Legal Forum’s symposium issue on “Law for the Next Pandemic”—envisions four “futures” for the United States’ pandemic response and considers the advantages and drawbacks of each. One approach, the Mass Surveillance strategy, relies on widespread population monitoring, rigorous contact tracing, and enforced isolation of the infected. That strategy has enabled several East and Southeast …
The Incoherence Of Prison Law, Justin Driver, Emma Kaufman
The Incoherence Of Prison Law, Justin Driver, Emma Kaufman
Faculty Articles
In recent years, legal scholars have advanced powerful critiques of mass incarceration. Academics have indicted America’s prison system for entrenching racism and exacerbating economic inequality. Scholars have said much less about the law that governs penal institutions. Yet prisons are filled with law, and prison doctrine is in a state of disarray. This Article centers prison law in debates about the failures of American criminal justice. Bringing together disparate lines of doctrine, prison memoirs, and historical sources, we trace prison law’s emergence as a discrete field — a subspeciality of constitutional law and a neglected part of the discipline called …
Factors Contributing To Diminished Long-Term Outcomes Of Secondary Infections, Alia Tayara
Factors Contributing To Diminished Long-Term Outcomes Of Secondary Infections, Alia Tayara
Honors Theses
It is widely known that patients suffer diminished long-term outcomes in the years following secondary infections, infectious diseases that occur during or after treatment of a primary infection such as influenza or COVID-19. One common secondary infection is pneumonia, which has become the most fatal hospital-acquired infection. The bacterium responsible for pneumonia is known as Pseudomonas aeruginosa. The cytotoxic supernatant in these studies was generated from a PA103 strain of Psuedomonas aeruginosa with a type III secretion system that maintains the ability to transfer exoenzymes ExoU and ExoT into target cells during infection. The focus of the following studies was …
Cross-Model Parameter Estimation In Epidemiology, Julia R. Fitzgibbons
Cross-Model Parameter Estimation In Epidemiology, Julia R. Fitzgibbons
Honors Theses and Capstones
No abstract provided.
Evaluating The Relationship Between Confidence And Anxiety During The Covid-19 Pandemic, Althea M. Devereux
Evaluating The Relationship Between Confidence And Anxiety During The Covid-19 Pandemic, Althea M. Devereux
Honors Theses and Capstones
No abstract provided.
Sars-Cov-2: An Investigation On Mutagenicity And Its Effects On Infectivity And Mortality, Tyler Elliott Silverwood
Sars-Cov-2: An Investigation On Mutagenicity And Its Effects On Infectivity And Mortality, Tyler Elliott Silverwood
Honors Theses and Capstones
SARS-CoV-2, the etiological agent of the COVID-19 pandemic, has rapidly become a worldwide public health concern. Classified as a betacoronavirus, it is the third human coronavirus (HCoV) to emerge in the 21st century that causes severe disease, alongside SARS-CoV and MERS-CoV. The genome consists of open reading frames encoding accessory proteins and four structural proteins, including the spike protein which is a key determinant of host cell tropism. Mutations within the genome, particularly the spike gene, have been linked in-vitro to increased binding affinity to the human receptor angiotensin-converting enzyme 2 (hACE2), increased fitness in human hosts, and immune evasion. …
Poor Clinical Outcomes Associated With Suboptimal Antibiotic Treatment Among Older Long-Term Care Facility Residents With Urinary Tract Infection: A Retrospective Cohort Study, Haley J. Appaneal, I. Shireman, Vrishali V. Lopes, Vincent Mor, David M. Dosa, Kerry L. Laplante, Aisling R. Caffrey
Poor Clinical Outcomes Associated With Suboptimal Antibiotic Treatment Among Older Long-Term Care Facility Residents With Urinary Tract Infection: A Retrospective Cohort Study, Haley J. Appaneal, I. Shireman, Vrishali V. Lopes, Vincent Mor, David M. Dosa, Kerry L. Laplante, Aisling R. Caffrey
Pharmacy Practice and Clinical Research Faculty Publications
Background: Antibiotic use is associated with several antibiotic-related harms in vulnerable, older long-term care (LTC) residents. Suboptimal antibiotic use may also be associated with harms but has not yet been investigated. The aim of this work was to compare rates of poor clinical outcomes among LTC residents with UTI receiving suboptimal versus optimal antibiotic treatment.
Methods: We conducted a retrospective cohort study among residents with an incident urinary tract infection (UTI) treated in Veterans Affairs LTC units (2013–2018). Potentially suboptimal antibiotic treatment was defined as use of a suboptimal initial antibiotic drug choice, dose frequency, and/or excessive treatment duration. The …
The Art And Science Of Drug Titration, Aisling R. Caffrey, P. Borrelli
The Art And Science Of Drug Titration, Aisling R. Caffrey, P. Borrelli
Pharmacy Practice and Clinical Research Faculty Publications
A “one-size-fits-all” approach has been the standard for drug dosing, in particular for agents with a wide therapeutic index. The scientific principles of drug titration, most commonly used for medications with a narrow therapeutic index, are to give the patient adequate and effective treatment, at the lowest dose possible, with the aim of minimizing unnecessary medication use and side effects. The art of drug titration involves the interplay of scientific drug titration principles with the clinical expertise of the healthcare provider, and an individualized, patient-centered partnership between the provider and the patient to review the delicate balance of perceived benefits …
Isolation And Characterization Of A Novel Bacteriophage Wo From Allonemobius Socius Crickets In Missouri, Jonah Kupritz, John Martin, Kerstin Fischer, Kurt C. Curtis, Joseph R. Fauver, Yuefang Huang, Young-Jun Choi, Wandy L. Beatty, Makedonka Mitreva, Peter U. Fischer
Isolation And Characterization Of A Novel Bacteriophage Wo From Allonemobius Socius Crickets In Missouri, Jonah Kupritz, John Martin, Kerstin Fischer, Kurt C. Curtis, Joseph R. Fauver, Yuefang Huang, Young-Jun Choi, Wandy L. Beatty, Makedonka Mitreva, Peter U. Fischer
Journal Articles: Epidemiology
Wolbachia are endosymbionts of numerous arthropod and some nematode species, are important for their development and if present can cause distinct phenotypes of their hosts. Prophage DNA has been frequently detected in Wolbachia, but particles of Wolbachia bacteriophages (phage WO) have been only occasionally isolated. Here, we report the characterization and isolation of a phage WO of the southern ground cricket, Allonemobius socius, and provided the first whole-genome sequence of phage WO from this arthropod family outside of Asia. We screened A. socius abdomen DNA extracts from a cricket population in eastern Missouri by quantitative PCR for Wolbachia surface protein …
Incident Tuberculosis Diagnoses In Children At High Risk For Disease, Milagros Wong, Julia M. Coit, Milagros Mendoza, Silvia S. Chiang, Helen Marin, Jerome T. Galea, Leonid Lecca, Molly F. Franke
Incident Tuberculosis Diagnoses In Children At High Risk For Disease, Milagros Wong, Julia M. Coit, Milagros Mendoza, Silvia S. Chiang, Helen Marin, Jerome T. Galea, Leonid Lecca, Molly F. Franke
Social Work Faculty Publications
We followed 35 children meeting a research definition for unconfirmed tuberculosis (TB) but in whom a pediatric pulmonologist did not diagnose or treat TB. After a median follow-up of 16.4 months, most children were not diagnosed with TB following a comprehensive evaluation. However, 2 were diagnosed with TB, demonstrating high TB risk (6%; exact 95% CI, 1%–19%). In some contexts, researchers may wish to supplement these research definitions with clinical decision data and longitudinal follow-up in order to improve specificity.
Prediction Tool To Identify Children At Highest Risk Of Tuberculosis Disease Progression Among Those Exposed At Home, Meredith B. Brooks, Leonid Lecca, Carmen Contreras, Roger Calderon, Rosa Yataco, Jerome Galea, Chuan-Chin Huang, Megan B. Murray, Mercedes C. Becerra
Prediction Tool To Identify Children At Highest Risk Of Tuberculosis Disease Progression Among Those Exposed At Home, Meredith B. Brooks, Leonid Lecca, Carmen Contreras, Roger Calderon, Rosa Yataco, Jerome Galea, Chuan-Chin Huang, Megan B. Murray, Mercedes C. Becerra
Social Work Faculty Publications
Background: There is a dearth of research to understand which children, among those who are exposed at home to tuberculosis (TB), are at the highest risk of TB disease, to tailor care. We sought to identify predictors of TB progression in children.
Methods: We conducted a prospective cohort study of children living with adults with pulmonary TB in Lima, Peru (2009–2012). We applied classification and regression tree analysis to examine potential predictors of incident TB disease during 12 months in 3 age groups (0–4, 5–9, and 10–14 years). We calculated the relative risk (RR) for top predictors in each age …
A Non-Specialist Depression Care Pathway For Adolescents Living With Hiv And Transitioning Into Adult Care In Peru: A Nested, Proof Of Concept Pilot Study, Jerome T. Galea, Carmen Contreras, Milagros Wong, Karen Ramos, Valentina Vargas, Hugo Sánchez, Renato A. Errea, Leonid Lecca, Molly F. Franke
A Non-Specialist Depression Care Pathway For Adolescents Living With Hiv And Transitioning Into Adult Care In Peru: A Nested, Proof Of Concept Pilot Study, Jerome T. Galea, Carmen Contreras, Milagros Wong, Karen Ramos, Valentina Vargas, Hugo Sánchez, Renato A. Errea, Leonid Lecca, Molly F. Franke
Social Work Faculty Publications
Background: Adolescents living with HIV (ALWH) are disproportionally impacted by depression, experiencing worse HIV outcomes. Integrated depression and HIV care may support antiretroviral adherence. This study pilot tested for proof of concept a basic depression care pathway for ALWH to inform depression care integration with HIV services in Peru.
Methods: ALWH were screened for depression with the Patient Health Questionnaire-9 (PHQ-9). Participants with PHQ-9 scores of ⩾10 or suicidal ideation (SI) were eligible for Psychological First Aid (PFA) delivered by non-mental health specialists. Participants with PHQ-9 re-assessments of ⩾20 or SI were referred to specialized services.
Results: Twenty-eight (11 female, …
Impact Of The Sars-Cov-2 Pandemic On Adolescents Living With Hiv In Lima, Peru, Renato A. Errea, Milagros Wong, Liz Senador, Alicia Ramos, Karen Ramos, Jerome T. Galea, Leonid Lecca, Hugo Sánchez, Carlos Benites, Molly F. Franke
Impact Of The Sars-Cov-2 Pandemic On Adolescents Living With Hiv In Lima, Peru, Renato A. Errea, Milagros Wong, Liz Senador, Alicia Ramos, Karen Ramos, Jerome T. Galea, Leonid Lecca, Hugo Sánchez, Carlos Benites, Molly F. Franke
Social Work Faculty Publications
Adolescents living with HIV (ALWH) have lower rates of virologic suppression and higher rates of immunologic decline compared to their older counterparts, potentially placing them at high-risk for developing severe SARS-CoV-2 disease. ALWH who are transitioning to adult care face additional challenges to remaining in care and adhering to treatment. In this special section we report the experiences of ALWH in the process of transitioning to adult HIV services during the COVID-19 pandemic. In first place, the government-mandated stay-at-home order has substantially limited access to full HIV care by restricting public transportation, HIV medication stock-outs, and the suspension of routine …
"In The Process Of Becoming": Constructing And Re-Constructing Gender In Twelfth-Century Women's Texts, Katelyn Bajorek
"In The Process Of Becoming": Constructing And Re-Constructing Gender In Twelfth-Century Women's Texts, Katelyn Bajorek
Renée Crown University Honors Thesis Projects - All
No abstract provided.
Is 17 Alpha-Hydroxyprogesterone Effective For Preventing Preterm Labor In High Risk Women?, Hannah E. Mercado
Is 17 Alpha-Hydroxyprogesterone Effective For Preventing Preterm Labor In High Risk Women?, Hannah E. Mercado
PCOM Physician Assistant Studies Student Scholarship
OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Is 17- alpha hydroxyprogesterone effective for preventing preterm labor in high risk women?”.
STUDY DESIGN: Review of one randomized, double blind, controlled trial, one randomized, double blind, placebo controlled trial and one randomized controlled trial published in English between 2015 and 2018.
DATA SOURCES: All three studies were gathered from peer- reviewed journals and found using PubMed.
OUTCOMES MEASURED: Preterm delivery defined as birth less than 37 weeks gestation for Facchinetti et al., Shadab et al. and Winer et al.6,7,8
RESULTS: The RCT performed by Facchinetti …
Forensic Implications For The Diagenetic Alteration Of The Stable Isotopic Composition Of Pig Ribs Following Exposure To Aqueous Conditions., Erin Martin
Electronic Theses and Dissertations, 2020-2023
This research involves the examination of the contribution of stable isotope analysis to the forensic anthropological objective of human identification. Oxygen isotopes, which vary in water in a predictable manner according to climatological and geographical factors, can be used to determine the region of origin of an unidentified individual following isotopic analysis of human skeletal remains. However, stable oxygen isotopes from human remains recovered from various aqueous environments may be altered by diagenetic processes that occur following deposition. The focus of this research is to determine potential diagenetic changes in the oxygen isotopic value (d18O) of Sus scrofa (domestic pig) …
Diagnostic Justice: Testing For Covid-19, Ashley Graham Kennedy, Bryan Cwik
Diagnostic Justice: Testing For Covid-19, Ashley Graham Kennedy, Bryan Cwik
Philosophy Faculty Publications and Presentations
Diagnostic testing can be used for many purposes, including testing to facilitate the clinical care of individual patients, testing as an inclusion criterion for clinical trial participation, and both passive and active surveillance testing of the general population in order to facilitate public health outcomes, such as the containment or mitigation of an infectious disease. As such, diagnostic testing presents us with ethical questions that are, in part, already addressed in the literature on clinical care as well as clinical research (such as the rights of patients to refuse testing or treatment in the clinical setting or the rights of …
Digest Of The Philadelphia College Of Osteopathic Medicine, Philadelphia College Of Osteopathic Medicine
Digest Of The Philadelphia College Of Osteopathic Medicine, Philadelphia College Of Osteopathic Medicine
PCOM Digest 2020s
The (2021 No. 2) issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:
- Updates
- Advancing Alumni
- Reimagining Public Health: Pivoting from Pandemic Response to Future Prevention
- Rethinking Burnout, Mental Health and Well-being
- A Pandemic Within a Pandemic: Addressing Marginalized and Minoritized Communities to Foster Recovery
- Class Notes
Evaluation Of Pediatric Patients Diagnosed With Lyme Disease In The Lehigh Valley, Jessica Phan, Katiemarie Vottero Do, Tibisay Villalobos Md, Kristin M. Held Wheatley Pharmd, Bcop, Farina Klocksieben, Kris Rooney Md
Evaluation Of Pediatric Patients Diagnosed With Lyme Disease In The Lehigh Valley, Jessica Phan, Katiemarie Vottero Do, Tibisay Villalobos Md, Kristin M. Held Wheatley Pharmd, Bcop, Farina Klocksieben, Kris Rooney Md
USF-LVHN SELECT
No abstract provided.
Factors Affecting Access To Administrative Health Data For Research In Canada: A Study Protocol, Cynthia Kendell, Adrian Levy, Geoff Porter, Elaine Gibson, Robin Urquhart
Factors Affecting Access To Administrative Health Data For Research In Canada: A Study Protocol, Cynthia Kendell, Adrian Levy, Geoff Porter, Elaine Gibson, Robin Urquhart
Articles, Book Chapters, & Popular Press
In Canada, most provinces have established administrative health data repositories to facilitate access to these data for research. Anecdotally, researchers have described delays and substantial inter-provincial variations in the timeliness of data access approvals and receipt of data. Currently, the reasons for these delays and variations in timeliness are not well understood. This paper provides a study protocol for (1) identifying the factors affecting access to administrative health data for research within select Canadian provinces, and (2) comparing factors across provinces to assess whether and how they contribute to inter-provincial variations in access to administrative health data for research.
Exploring The Food And Drug Administration’S Review And Approval Of Entresto (Sacubitril/Valsartan), Ashley Eadie, Keith Brunt, Matthew Herder
Exploring The Food And Drug Administration’S Review And Approval Of Entresto (Sacubitril/Valsartan), Ashley Eadie, Keith Brunt, Matthew Herder
Articles, Book Chapters, & Popular Press
Federal regulatory agencies such as the United States Food and Drug Administration review pharmacological evidence to ensure the safety and efficacy of new and repurposed pharmaceuticals prior to market approval. The discussions, disagreements and procedural decisions contained within such reviews offer unique insight into a pharmaceutical's strengths, weaknesses and opportunities, yet are often overlooked as a significant source of pharmacological information for research and development. To highlight the value of such resources, we present a case study on Entresto, a first-in-class angiotensin receptor-neprilysin inhibitor for the treatment of heart failure with reduced ejection fraction, and explore the regulatory rationale underlying …