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Small Business Owner App To Showcase Covid Prevention Policies And Reopening Guidelines, Christopher Duran

Theses, Dissertations and Culminating Projects

Almost a year after the emergence of the Coronavirus, the pandemic still negatively affects the world’s economy and quality of life. In the U.S., Covid-19 has shut down nearly 100,000 businesses.

The goal of this project is to develop an app that can assist business owners to accurately display their coronavirus prevention methods so that people can feel safe while using their services. This project will focus on how the business owner (Vendor) will be able to interact, utilize, and display important information for the customer (Patron) to use.

The vendor will be able to create an individual profile for …

New Views On The Ingenious Applications Of Ag Nanoparticles As A Sensor For Antibiotic Detection And As A Potent Antimicrobial Agent, Keyur Bhatt, Anita Kongor, Mohd Atharb, Vinod Jain

Journal of Metals, Materials and Minerals

Nanotechnology uses exceptional approaches for the control of bacterial infections which uncovers the potential function of bio-systems at nano-scale level. Compared to silver ions, silver nanoparticles possess enhanced physicochemical stability and low bio-toxicity properties. The intrinsic chemical framework of silver nanoparticles is prone to exhibit a significant chemistry when used as sensor and as therapeutic. Nowadays, silver is used in (nano-) medicine, in the form of nanoparticles to optimize its therapeutic property for controlling infections caused by multidrug-resistant bacteria. Exclusive use of antibiotics as medicines and its discharge from the body of the infected person or animals into the sewage …

Passive Immunization Against Invasive Salmonella Enterica, Angelene Richards

Legacy Theses & Dissertations (2009 - 2024)

The Gram-negative bacterium, Salmonella enterica is a prominent etiologic agent of both diarrheal disease and enteric fever that encompasses over 2500 serovars, including S. Typhimurium (STm) and S. Typhi (STy). S. enterica is transmitted through contaminated food and water and, following ingestion, invades the gastrointestinal (GI) mucosa. The bacterium uses flagellar-based motility to target microfold (M) cells overlying gut-associated lymphoid tissues known as Peyer’s patches in the small intestine. Entry into Peyer’s patch tissues is a pivotal step in the infection process, as the bacterium can then disseminate systemically in the host. Given the rise in antibiotic resistance amongst S. …

Tick Bites And Blood Relations : Regional Relationships And Interpretations Of Lyme Disease Risk In New York's Hudson River Corridor, Jessica Somers

Legacy Theses & Dissertations (2009 - 2024)

Lyme disease is a bacterial pathogen that spreads from animals to humans through bites from blacklegged ticks (Ixodes scapularis). The disease is a public health problem causing both physical suffering and increased health care spending since the 1980s. A snapshot of Lyme disease coverage in the popular media shows that most people prioritize conversations about Lyme disease diagnosis and treatment over prevention concerns. Anthropology has recently examined peoples’ anxieties and debates regarding the diagnosis and treatment of Lyme disease in the United States. There has been less work within the discipline on Lyme and tick-borne disease risk perceptions. This dissertation …

Intrabodies Reveal Critical Steps Involved In Ricin's Interactions With The Ribosome, Timothy Francis Czajka

Legacy Theses & Dissertations (2009 - 2024)

Ricin is a highly lethal protein toxin derived from the seeds of the castor plant, Ricinus communis. It is a Type II ribosome inactivating protein (RIP), meaning it is a heterodimer with one subunit, ricin toxin B (RTB), that mediates cell surface attachment and intracellular trafficking and a second subunit, ricin toxin A (RTA), that irreversibly shuts down protein synthesis in the cytosol. During trafficking, RTA and RTB necessarily separate in the endoplasmic reticulum, wherein RTA unfolds and translocates into the cytosol where it refolds into an enzymatically active conformation. RTA is remarkably fast acting and efficient, with few molecules …

The Phosphodiesterase, Rv0805, Is An Unheralded Component Of Tb Complex Mycobacterial Physiology In And Beyond Camp Homeostasis, James R. Mcdowell

Legacy Theses & Dissertations (2009 - 2024)

Phosphodiesterases (PDEs) are integral components of 3’,5’-cyclic adenosine monophosphate (cAMP) signaling pathways by degrading cAMP to modulate the concentration, duration, and localization of the cAMP signal which maintains the specificity of cAMP pathways. The human pathogen, Mycobacterium tuberculosis (Mtb) has a unique cAMP network architecture with at least 15 adenylyl cyclases (ACs) that generate cAMP, but only one characterized PDE, Rv0805, which is found exclusively in pathogenic mycobacteria. Rv0805 can influence Mtb cAMP levels but the absence of Rv0805 orthologs in non-pathogenic mycobacteria and apparent separation of Rv0805 from cAMP directed roles led to numerous questions surrounding PDE function in …

Longitudinal Examination Of Contextual Risk, Promotive Factors, And Psychosocial Functioning Using Structural Equation Modeling With A Sample Of Serious Adolescent Offenders, Daniel J. Knauer

Legacy Theses & Dissertations (2009 - 2024)

Mental health problems, including substance use problems, are more prevalent among adolescent criminal offenders than among the general population and are associated with an elevated risk of re-offending. It is important to understand what factors are associated with serious adolescent offenders’ future mental health and re-offending outcomes to promote their positive development. This study examined potential mechanisms behind established relationships between risk factors for mental health and criminal offending and psychosocial outcomes while integrating ecological theory and a risk and protective framework. To do this, a mediation model was examined using structural equation modeling in which contextual risk was hypothesized …

Applied Methodologies Demonstrated Through Three Independent Studies For Assessing The Effects Of Socioeconomic, Environmental Chemical Exposure, And Therapeutic Factors On Oncological Diseases And Covid-19, Bayarmagnai Maggie Munkhjargal

Legacy Theses & Dissertations (2009 - 2024)

When trying to understand risk factors for a disease, even before we know the causal agents, it is necessary to create a surveillance data set that answers the questions of who, when, and where, and includes any potential covariates which may either promote or prevent the disease. There are a wide variety of surveillance data. For example, hospital discharge data, such as the New York Statewide Planning and Research Cooperative System (SPARCS) data, encompass all hospitalized cases in the state, while clinical datasets cover a specially constructed population in pursuit of research of a certain disease type. Analysis of surveillance …

Evaluating The Incidence Of Melanoma And Lung Cancer Of Current And Former Active-Duty U.S. Military Who Were Deployed In Support Of Operation Enduring Freedom And Operation Iraqi Freedom, Brian Kovacic

Theses and Dissertations--Epidemiology and Biostatistics

The incidence of melanoma and lung cancer has been gradually increasing in the United States over the past three decades with the reputed causes due to etiological and environmental exposures, and tobacco usage. There has been concern that melanoma and lung cancer incidence among military personnel may be associated with deployment to environments with intense sun exposure and increased smoking rates due to post-traumatic stress disorder. The aim of this study was to examine associations between deployment in support of Operation Enduring Freedom (OEF) or Operation Iraqi Freedom (OIF), from 2001 through 2015, with subsequent melanoma and lung cancer incidence. …

Program Development Using Intervention Mapping In Primary Healthcare Settings To Address Elder Abuse: A Randomized Controlled Pilot Study, Sonia Oveisi, Lynda A. Stein, Forozan Olfati, Shima Jahed

Psychology Faculty Publications

Background: Abuse of elderly women is of great concern and yet relatively little is known about interventions.

Objectives: The aim of this study was to develop and test a culturally informed treatment, based on Intervention Mapping (IM), for primary healthcare settings. The intervention targets family members of elderly women and seeks to reduce elder abuse.

Methods: N = 80 family members of elderly women were randomized to intervention or control. Elderly women completed assessment prior to randomization. Elder abuse was measured by self-reported frequency of neglect, physical, psychological, and financial abuse in the last 2 months across 16 items. Intervention …

Unsafe At Any Campus: Don't Let Colleges Become The Next Cruise Ships, Nursing Homes, And Food Processing Plants, Peter H. Huang, Debra S. Austin Dr

Indiana Law Journal

The decision to educate our students via in-person or online learning environments while COVID-19 is unrestrained is a false choice, when the clear path to achieve our chief objective safely, the education of our students, can be done online. Our decision-making should be guided by the overriding principle that people matter more than money. We recognize that lost tuition revenue if students delay or defer education is an institutional concern, but we posit that many students and parents would prefer a safer online alternative to riskier in-person options, especially as we get closer to fall, and American death tolls rise. …

Crisis And Cultural Evolution: Steering The Next Normal From Self-Interest To Concern And Fairness, Robert A. Bohrer

Faculty Scholarship

This essay examines the current time of crisis and offers a vision of the way in which our society and our law can evolve in response. Crises of this scale are evolution-forcing events and I argue that the current moment can move us towards a fundamentally different vision of law and justice. It is the first essay or article to show that the autonomous pursuit of self-interest was a common assumption or value in the major intellectual forces of the twentieth century: classical free market economics, behavioral economics, and sociobiology, as well as in the competing visions of a just …

Where’S The Meat? Lochner And The President’S Executive Order, Catherine M.A. Mccauliff

Nebraska Law Review

Rarely do we get the opportunity, distasteful as it may be in this situation, to relive an older Supreme Court case in real time. Today’s situation involving the meatpackers, some of whose employers are taking no precautions to protect against the pandemic virus called COVID-19, is not (yet) in the courts but comes to us in the form of a presidential executive order. These circumstances recall a compelling case from the early twentieth century in which workers similarly faced conditions dangerous to their health and well-being.

In Lochner v. New York, a majority of the Supreme Court, in an …

Do Initial Hematologic Indices Predict The Severity Of Covid-19 Patients?, Ali̇ Asan, Yasemi̇n Üstündağ, Ni̇zameddi̇n Koca, Abdullah Şi̇mşek, Hali̇l Erkan Sayan, Hülya Parildar, Burcu Dalyan Ci̇lo, Kağan Huysal

Turkish Journal of Medical Sciences

Background/aim: In this study, we aimed to evaluate the initial hematological findings analyzed on admission in confirmed COVID-19 patients who were transferred to the intensive care unit (ICU), to predict possible hematological indices. Materials and methods: Initial neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), red cell distribution width to platelet ratio (RPR), mean platelet volume to platelet ratio, and lymphocyte multiplied by platelet count (LYM × PLT), of 695 patients with laboratory-confirmed COVID-19 were investigated and comparisons were made between the mild/moderate and severe groups. Results: The proportion of COVID-19 cases admitted …

Hydroxychloroquine Plus Azithromycin And Early Hospital Admission Are Beneficial Incovid-19 Patients: Turkish Experience With Real-Life Data, Eli̇f Tanriverdi̇, Mustafa Çörtük, Bi̇nnaz Zeynep Yildirim, Efsun Gonca Uğur Chousein, Demet Turan, Hali̇t Çinarka, Mehmet Aki̇f Özgül, Erdoğan Çeti̇nkaya

Turkish Journal of Medical Sciences

Background/aim: New treatment regimens for COVID-19, which has threatened the world recently, continue to be investigated. Although some of the treatments are promising, it is thought to be early to state that there is definitive treatment. Experiences and treatment protocol studies from treatment centers are still important. The aim of this study is to evaluate factors affecting the treatment process of the first cases followed in our clinic. Materials and methods: The consecutive hospitalized patients with COVID-19 pneumonia were analyzed in this retrospective and cross-sectional study. Data were recorded from the electronic and written files of patients. Results: Eighty-three patients …

Efficacy Of Convalescent Plasma According To Blood Groups In Covid-19 Patients, Tuba Hacibeki̇roğlu, Yasi̇n Kalpakçi, Ahmed Ci̇had Genç, İlhan Hacibeki̇roğlu, Cenk Sunu, Adem Saricaoğlu, Yakup Tomak, Oğuz Karabay, Mehmet Köroğlu

Turkish Journal of Medical Sciences

Background/aim: In this study, we aim to investigate the efficacy of convalescent plasma (CP) according to blood groups (BGs) in the treatment of critically ill patients diagnosed with COVID-19. Materials and methods: Twenty-eight critically ill and laboratory-confirmed COVID-19 patients who were admitted to the intensive care unit (ICU) of Sakarya University, Medical Faculty were included in the study. Patients were divided into 2 groups: patients who received anti-A antibody (Ab) containing CP (BG O and B) and those who did not receive CP containing anti-A Ab (BG A and AB). Results: Among the 28 patients, 13 patients received anti-A Ab …

Projecting The Course Of Covid-19 In Turkey: A Probabilistic Modeling Approach, Aybar Can Acar, Ahmet Görkem Er, Hüseyi̇n Cahi̇t Burduroğlu, Seher Nur Sülkü, Yeşi̇m Aydin Son, Levent Akin, Serhat Ünal

Turkish Journal of Medical Sciences

Background/aim: The COVID-19 pandemic originated in Wuhan, China, in December 2019 and became one of the worst global health crises ever. While struggling with the unknown nature of this novel coronavirus, many researchers and groups attempted to project the progress of the pandemic using empirical or mechanistic models, each one having its drawbacks. The first confirmed cases were announced early in March, and since then, serious containment measures have taken place in Turkey. Materials and methods: Here, we present a different approach, a Bayesian negative binomial multilevel model with mixed effects, for the projection of the COVID-19 pandemic and we …

The Investigation Of Adrenal Involvement In Carbapenem Resistant Acinetobacterbaumannii Sepsis: Experimental Mouse Model, Esma Eryilmaz Eren, Gökçen Di̇nç, Olgun Kontaş, Emi̇ne Alp Meşe, Mehmet Doğanay

Turkish Journal of Medical Sciences

Background/aim: In the last years, incidence of carbapenem resistant Acinetobacter baumannii sepsis is increasing with high mortality. However, it is not clear whether this is due to inadequate antimicrobial choice or a more severe clinical course. We aimed to evaluate the inflammation and adrenal involvement in the carbapenem resistant A. baumannii by using experimental mouse model sepsis. Materials and methods: Balb/c female mice were randomly put into control and three sepsis groups (A. baumannii susceptible to carbapenem-CSAB-, A. baumannii resistant to carbapenem-CRAB-, Escherichia coli). A total of sixty mice were included in this study with each group having 15 mice. …

Expression Profiles Of Interferon-Related Genes In Cells Infected With Influenza A Viruses Or Transiently Transfected With Plasmids Encoding Viral Rna Polymerase, Eli̇f Çağlayan, Kadi̇r Turan

Turkish Journal of Biology

Influenza A viruses frequently change their genetic characteristics, which leads to the emergence of new viruses. Consequently, elucidation of the relationship between influenza A virus and host cells has a great importance to cope with viral infections. In this study, it was aimed to determine expression profiles of interferon response genes in human embryonic kidney 293 (HEK293) cells infected with human (A/WSN-H1N1) and avian influenza A viruses (duck/Pennsylvania/10218/84/H5N2) or transfected with plasmids encoding viral RdRP subunits and, to obtain clues about the genes that may be important for the viral pathogenesis. The HEK293 cells cultured in a 12-well plate were …

Current Mutatome Of Sars-Cov-2 In Turkey Reveals Mutations Of Interest, Doğa Eski̇er, Evren Akalp, Özlem Dalan, Gökhan Karakülah, Yavuz Oktay

Turkish Journal of Biology

As the underlying pathogen for the COVID-19 pandemic that has affected tens of millions of lives worldwide, SARS-CoV-2 and its mutations are among the most urgent research topics worldwide. Mutations in the virus genome can complicate attempts at accurate testing or developing a working treatment for the disease. Furthermore, because the virus uses its own proteins to replicate its genome, rather than host proteins, mutations in the replication proteins can have cascading effects on the mutation load of the virus genome. Due to the global, rapidly developing nature of the COVID-19 pandemic, local demographics of the virus can be difficult …

Prediction Of Host-Pathogen Protein Interactions By Extended Network Model, İrfan Kösesoy, Murat Gök, Tamer Kahveci̇

Turkish Journal of Biology

Knowledge of the pathogen-host interactions between the species is essentialin order to develop a solution strategy against infectious diseases. In vitro methods take extended periods of time to detect interactions and provide very few of the possible interaction pairs. Hence, modelling interactions between proteins has necessitated the development of computational methods. The main scope of this paper is integrating the known protein interactions between thehost and pathogen organisms to improve the prediction success rate of unknown pathogen-host interactions. Thus, the truepositive rate of the predictions was expected to increase.In order to perform this study extensively, encoding methods and learning algorithms …

A Deep Transfer Learning Based Model For Automatic Detection Of Covid-19from Chest X-Rays, Prateek Chhikara, Prakhar Gupta, Prabhjot Singh, Tarunpreet Bhatia

Turkish Journal of Electrical Engineering and Computer Sciences

Deep learning in medical imaging has revolutionized the way we interpret medical data, as high computational devices' capabilities are far more than their creators. With the pandemic causing havoc for the second straight year, the findings in our paper will allow researchers worldwide to use and create state-of-the-art models to detect affected persons before it reaches the R number. The paper proposes an automated diagnostic tool using the deep learning models on chest x-rays as an input to reach a point where we surpass this pandemic (COVID-19 disease). A deep transfer learning-based model for automatic detection of COVID-19 from chest …

On The Local And Global Stability Of An Sirs Epidemic Model With Logistic Growth And Information Intervention, İrem Çay

Turkish Journal of Mathematics

In this study, we investigate an susceptible-infected-recovered-susceptible (SIRS) epidemic model with logistic growth and information intervention. Firstly, the basic reproduction number $R_0$ is defined and the main results are given in terms of local stability. Then, sufficient conditions for the global stability of endemic equilibrium are obtained. Finally, some numerical simulations are given to validate our theoretical conclusions.

On The Spectral And Scattering Properties Of Eigenparameter Dependent Discrete Impulsive Sturm-Liouville Equations, Yelda Aygar Küçükevci̇li̇oğlu, Elgi̇z Bayram, Güher Gülçehre Özbey

Turkish Journal of Mathematics

This work develops scattering and spectral analysis of a discrete impulsive Sturm-Liouville equation with spectral parameter in boundary condition. Giving the Jost solution and scattering solutions of this problem, we find scattering function of the problem. Discussing the properties of scattering function, scattering solutions, and asymptotic behavior of the Jost solution, we find the Green function, resolvent operator, continuous and point spectrum of the problem. Finally, we give an example in which the main results are made explicit.

Anti-Mycobacterial Activity And Chemical Composition Of Essential Oils And Phenolicextracts Of The Balsam Of Liquidambar Orientalis Mill. (Altingiaceae), Tüli̇n Aşkun, Mi̇ne Kürkçüoğlu, Pinar Güner

Turkish Journal of Botany

Liquidambar orientalis Mill. (Altingiaceae) is known in Turkish as 'sığla' or ,'günlük' due to its gum-like exudate. Its exudate, `balsam of Liquidambar? (BL), is of great commercial importance because it has pharmaceutical properties and is rich in essential oils and phenolics. In this study, we investigated the phenolic profile of L. orientalis. using HPLC, and 5 compounds from BL-1, (juglone, naringenin, rosmarinic acid, vanillic acid, echinacoside) and 4 compounds from BL-2 (juglone, apigenin-7-glucoside, naringenin, vanillic acid) were reported for the first time. A total of six new flavonoids (juglone, naringenin, rosmarinic acid, echinacoside, vanillic acid, and apigenin-7-glucoside) were identified from …

Applications Of Crispr/Cas9-Based Genome Editing In The Plant Biology, Yingzhuan Zheng, Qianqian Li, Mingwang Ye, Aie Cehn, Hongyang Wang

Turkish Journal of Botany

Clustered regularly interspaced short palindromic repeats/CRISPR-associated proteins (CRISPR/Cas) is an acquired immune system found in bacteria and archaea that can specifically silence or degrade a foreign single or double strand nucleic acid to protect it from infection. In recent years, the CRISPR/Cas9 system has rapidly been evolved into a genome editing technology, in which the Cas9 endonuclease can be targeted to specific DNA sequences by guide RNAs (gRNAs) that are easily programmable. Due to simplicity, specificity and high efficiency, CRISPR/Cas9 is gradually replacing other gene editing technologies and has been implemented in basic and applied plant sciences to boost yield, …

The Effect Of Weekend Curfews On Epidemics: A Monte Carlo Simulation, Hakan Kaygusuz, Ahmet Ni̇hat Berker

Turkish Journal of Biology

The ongoing COVID-19 pandemic is being responded with various methods, applying vaccines, experimental treatment options, total lockdowns or partial curfews. Weekend curfews are among the methods for reducing the number of infected persons, and this method is practically applied in some countries such as Turkey. In this study, the effect of weekend curfews on reducing the spread of a contagious disease, such as COVID-19, is modeled using a Monte Carlo algorithm with a hybrid lattice model. In the simulation setup, a fictional country with three towns and 26,610 citizens were used as a model. Results indicate that applying a weekend …

Binary-Qsar Guided Virtual Screening Of Fda Approved Drugs And Compounds In Clinical Investigation Against Sars-Cov-2 Main Protease, Lalehan Oktay, Ece Erdemoğlu, İlayda Tolu, Yeşi̇m Yumak, Ayşenur Özcan, Eli̇f Acar, Şehri̇ban Büyükkiliç, Alpsu Olkan, Serdar Durdaği

Turkish Journal of Biology

With the emergence of the new SARS-CoV-2 virus, drug repurposing studies have gained substantial importance. Combined with the efficacy of recent improvements in ligand- and target-based virtual screening approaches, virtual screening has become faster and more productive than ever. In the current study, an FDA library of approved drugs and compounds under clinical investigation were screened for their antiviral activity using the antiviral therapeutic activity binary QSAR model of the MetaCore/MetaDrug platform. Among 6733-compound collection, we found 370 compounds with a normalized therapeutic activity value greater than a cutoff of 0.75. Only these selected compounds were used for molecular docking …

The Current State Of Validated Small Molecules Inhibiting Sars-Cov-2 Non-Structural Proteins, Fati̇h Kocabaş, Merve Uslu

Turkish Journal of Biology

The current COVID-19 outbreak has had a profound influence on public health and daily life. Despite all restrictions and vaccination programs, COVID-19 still can lead to fatality due to a lack of COVID-19-specific treatments. A number of studies have demonstrated the feasibility to develop therapeutics by targeting underlying components of the viral proteome. Here we reviewed recently developed and validated small molecule inhibitors of SARS-CoV-2's nonstructural proteins. We described the validation level of identified compounds specific for SARS-CoV-2 in the presence of in vitro and in vivo supporting data. The mechanisms of pharmacological activity, as well as approaches for developing …

Coronavac (Sinovac) Covid-19 Vaccine-Induced Molecular Changes In Healthy Human Serum By Infrared Spectroscopy Coupled With Chemometrics, Ayça Doğan Mollaoğlu, Rafi̇g Gurbanov, Mete Severcan, Feri̇de Severcan

Turkish Journal of Biology

From the beginning of the COVID-19 coronavirus pandemic in December of 2019, the disease has infected millions of people worldwide and caused hundreds of thousands of deaths. Since then, several vaccines have been developed. One of those vaccines is inactivated CoronaVac-Sinovac COVID-19 vaccine. In this proof of concept study, we first aimed to determine CoronaVac-induced biomolecular changes in healthy human serum using infrared spectroscopy. Our second aim was to see whether the vaccinated group can be separated or not from the non-vaccinated group by applying chemometric techniques to spectral data. The results revealed that the vaccine administration induced significant changes …