Digital Commons Network^™

Variability In The Use Of Novel Diagnostic Technology In Children With Suspected Encephalitis And In The Management Of Emerging Encephalitides By Pediatric Infectious Disease Providers, Walter N. Dehority, Andrew B. Janowski, Kevin Messacar, Philip M. Polgreen, Susan E. Beekmann

Pediatrics Research and Scholarship

We surveyed pediatric infectious disease physicians through the Infectious Disease Society of America's Emerging Infections Network regarding the diagnosis and management of encephalitis. We identified practice variations, particularly with the use of new diagnostic modalities and management of autoimmune encephalitides. These findings may inform the creation of updated management guidelines.

The Impact Of Disaster Tabletop Exercise On The Nurses Knowledge On Emergency Preparedness And The Influence On Professional Quality Of Life, Vivian Fuentes

All Publications

No abstract provided.

Evaluation Of Various Analogs Of High-Throughput Screening Target Molecules As Dape Inhibitors Using The Dape Ninhydrin Assay For Novel Antibiotic Discovery, Megan Beulke

Undergraduate Research and Engagement Symposium

In our medicinal organic chemistry research lab, I am performing a ninhydrin-based enzyme inhibition assay, previously developed in our lab, to discover novel antibiotics to combat antibiotic resistance that poses an imminent public health crisis. These drugs target the bacterial enzyme N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), a crucial enzyme to bacterial survival due to its involvement in the biosynthetic pathway of lysine, an amino acid essential to protein synthesis and mDAP, which is essential for bacterial cell wall construction. This pathway is exclusive to bacteria and is not found in mammalian cells, thus inhibition of this enzyme should be selectively toxic …

Depression As A Function Of Social Support In Transgender And Cisgender Individuals With Sexually Transmitted Diseases, Candace Roberson B.S.

Graduate Academic Symposium

No abstract provided.

Medical School Watercooler Newsletter - April 29, 2021, Lindsey Lyle

Watercooler Newsletter

This is the April 29, 2021 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Commencement, honors ceremonies set for COM Class of 2021
• Cybersecurity safety meeting set for may 6
• College of Medicine faculty recognized as 'Top Profs'
• Meet a Med Student: Mary Katherine Moore
• 'A flamethrower of chemicals': Researcher focuses on dangers of vaping

A Bundled Approach To Integrative Care For Peripherally Inserted Extracorporeal Membrane Oxygenation Cannula Insertion Site, Kelly Garaffa, Mickey Amos

Nursing DNP Projects

Purpose and Rationale: This project is designed to translate the collective knowledge and evidence-based interventions surrounding the reduction of central line-associated bloodstream infections (CLABSIs) and use these evidence-based practices to create an extracorporeal membrane oxygenation (ECMO) cannula site bundle. The desired outcome of creating an ECMO cannula-site bundle is increased cannula site integrity, decreased frequency of dressing changes, and minimized risk of cannula-site infections.

Synthesis of Evidence: Currently, there are no clinical practice guidelines for ECMO cannula site care to guide bedside practice. The ELSO Infectious Disease Taskforce recommends implementation of a CLABSI bundle for ECMO site care, but many …

Heat Emergencies: Perceptions And Practices Of Community Members And Emergency Department Healthcare Providers In Karachi, Pakistan: A Qualitative Study, Uzma Rahim Khan, Naveed Ahmed, Rubaba Naeem, Umerdad Khudadad, Sarwat Masud, Nadeem Ullah Khan, Junaid Abdul Razzak

Department of Emergency Medicine

Heat waves are the second leading cause of weather-related morbidity and mortality affecting millions of individuals globally, every year. The aim of this study was to understand the perceptions and practices of community residents and healthcare professionals with respect to identification and treatment of heat emergencies. A qualitative study was conducted using focus group discussions and in-depth interviews, with the residents of an urban squatter settlement, community health workers, and physicians and nurses working in the emergency departments of three local hospitals in Karachi. Data was analyzed using content analysis. The themes that emerged were (1) perceptions of the community …

Application Of Eh-Ph Diagrams On Acid Leaching Systems For The Recovery Of Rees From Bastnaesite, Monazite And Xenotime, Peijia Lin, Xinbo Yang, Joshua M. Werner, Rick Q. Honaker

Mining Engineering Faculty Publications

Bastnaesite, monazite and xenotime are rare earth minerals (REMs) that are typical sources for rare earth elements (REEs). To advance the understanding of their leaching and precipitation behavior in different hydrometallurgical processes, Eh-pH diagrams were constructed and modified using the HSC 9.9 software. The aqueous stability of rare earth elements in H₂O and acid leaching systems, i.e., the REE-Ligands-H₂O systems, were depicted and studied based on the Eh-pH diagrams. This study considers the most relevant lixiviants, their resulting equilibrium states and the importance in the hydrometallurgical recovery of rare earth elements (REMs). A literature review was …

Preliminary Study Of Cave Sample Storage Conditions On Fungal Community Diversity, Daniel B. Raudabaugh, Nelda A. Rivera, Gretchen C. Anchor, Elizabeth Bach, Andrew N. Miller, Nohra E. Mateus-Pinilla

KIP Articles

We investigated the effect of varying storage time and storage temperature on fungal species’ isolation as part of a case study of Illinois cave sediment samples. A deeper understanding of cave fungal communities may influence eco-epidemiology studies of emerging or re-emerging cave fungal pathogens. Using culture-dependent techniques, we isolated geophilic fungi from homogeneous cave sediment samples from three Illinois caves. Each sample was stored under five different temperatures ranging from −80 °C to 22 °C. Cave sediment was periodically removed at five different time periods from 48 h to 1 year, serially diluted with distilled water, lawn plated onto two …

Normalizing Community Mask-Wearing: A Cluster Randomized Trial In Bangladesh, Jason Abaluck, Laura H. Kwong, Ashley Styczynski, Ashraful Haque, Md. Alamgir Kabir, Ellen Bates-Jeffries, Emily Crawford, Jade Benjamin-Chung, Salim Benhachmi, Shabib Raihan, Shadman Rahman, Neeti Zaman, Peter J. Winch, Md. Maqsud Hossain, Hasan Mahmud Reza, Stephen P. Luby, Ahmed Musfiq Mobarak

Cowles Foundation Discussion Papers

Background: A growing body of scientific evidence suggests that face masks can slow the spread of COVID-19 and save lives, but mask usage remains low across many parts of the world, and strategies to increase mask usage remain untested and unclear. Methods: We conducted a cluster-randomized trial of community-level mask promotion in rural Bangladesh involving 341,830 adults in 600 villages. We employed a series of strategies to promote mask usage, including free household distribution of surgical or cloth masks, distribution and promotion at markets and mosques, mask advocacy by Imams during Friday prayers, role modeling by local leaders, promoters …

The Impact Of Community Masking On Covid-19: A Cluster Randomized Trial In Bangladesh, Jason Abaluck, Laura H. Kwong, Ashley Styczynski, Ashraful Haque, Md. Alamgir Kabir, Ellen Bates-Jeffries, Emily Crawford, Jade Benjamin-Chung, Shabib Raihan, Shadman Rahman, Salim Benhachmi, Neeti Zaman, Peter J. Winch, Md. Maqsud Hossain, Hasan Mahmud Reza, Abdullah All Jaber, Shawkee Gulshan Momen, Faika Laz Bani, Aura Rahman, Tahrima Saiha Huq, Stephen P. Luby, Ahmed Mushfiq Mobarak

Cowles Foundation Discussion Papers

Background: Mask usage remains low across many parts of the world during the COVID- 19 pandemic, and strategies to increase mask-wearing remain untested. Our objectives were to identify strategies that can persistently increase mask-wearing and assess the impact of increasing mask-wearing on symptomatic SARS-CoV-2 infections. Methods: We conducted a cluster-randomized trial of community-level mask promotion in rural Bangladesh from November 2020 to April 2021 (N=600 villages, N=342,126 adults). We cross-randomized mask promotion strategies at the village and household level, including cloth vs. surgical masks. All intervention arms received free masks, information on the importance of masking, role modeling by community …

Feeding Cannabidiol (Cbd)-Containing Treats Did Not Affect Canine Daily Voluntary Activity, Elizabeth M. Morris, Susanna E. Kitts-Morgan, Dawn M. Spangler, Jessica Gebert, Eric S. Vanzant, Kyle R. Mcleod, David L. Harmon

Animal and Food Sciences Faculty Publications

Growing public interest in the use of cannabidiol (CBD) for companion animals has amplified the need to elucidate potential impacts. The purpose of this investigation was to determine the influence of CBD on the daily activity of adult dogs. Twenty-four dogs (18.0 ± 3.4 kg, 9 months−4 years old) of various mixed breeds were utilized in a randomized complete block design with treatments targeted at 0 and 2.5 mg (LOW) and at 5.0 mg (HIGH) CBD/kg body weight (BW) per day split between two treats administered after twice-daily exercise (0700–0900 and 1,700–1,900 h). Four hours each day [1,000–1,200 h (a.m.) …

Thyreos Completes Seed Funding From Invest Nebraska, Strategic Angel Investors, Nebraska Combine

The Combine

First paragraph:

Thyreos (https://www.thyreosvaccines.com/), a vaccine company that is developing a novel vaccine platform that protects against a range of herpesviruses, has announced a $750,000 investment round led by Invest Nebraska with participation from other local angel investors in the animal health and veterinary space.

Staphylococcus Aureus Floating Biofilm Formation And Phenotype In Synovial Fluid Depends On Albumin, Fibrinogen, And Hyaluronic Acid, Samantha Knott, Dylan Curry, Neil Zhao, Pallavi Metgud, Sana Dastgheyb, Caroline Purtill, Marc I. Harwood, Md, Antonia F Chen, Thomas P Schaer, Michael Otto, Noreen J. Hickok

Department of Orthopaedic Surgery Faculty Papers

Biofilms are typically studied in bacterial media that allow the study of important properties such as bacterial growth. However, the results obtained in such media cannot take into account the bacterial localization/clustering caused by bacteria–protein interactions in vivo and the accompanying alterations in phenotype, virulence factor production, and ultimately antibiotic tolerance. We and others have reported that methicillin-resistant or methicillin-susceptible Staphylococcus aureus (MRSA or MSSA, respectively) and other pathogens assemble a proteinaceous matrix in synovial fluid. This proteinaceous bacterial aggregate is coated by a polysaccharide matrix as is characteristic of biofilms. In this study, we identify proteins important for this …

The Third Plague Pandemic And British India: A Transformation Of Science, Policy, And Indian Society, Rebecca L. Burrows

Tenor of Our Times

This paper seeks to understand the role of the Third Plague Pandemic's overwhelming devastation in colonial India, specifically through the new advancements in scientific understanding, unheard of proactive prevention measures, and increased separation between the colonial powers of Great Britain and the common people of India.

Overcoming Obesity: Provider Reminders And Education In Pediatrics, Michelle Warren

Evidence-Based Practice Project Reports

The prevalence of pediatric overweight and obesity is rising globally (Di Cesare et al., 2019) and results in lifelong chronic health problems and an estimated annual healthcare cost of $14.1 billion (Trasande & Chatterjee, 2009). The purpose of this evidence-based practice project was to address overweight and obesity in patients between the ages of five and 12 years through the provision of provider reminders, education, and guidelines. Primary outcomes included frequency of diagnosis, frequency of patient referrals, return to see times, and frequency of patient nutrition and activity education while secondary outcomes included patient weight, body mass index (BMI), and …

A Novel Application Of Galleria Mellonella Larvae To Study Pathogenesis Of Rickettsia Rickettsii Infection, Jacob M. Jones

Honors College Theses

Rickettsia are obligate intracellular tick-borne bacteria that cause acute undifferentiated febrile illness accompanied by headache, malaise, myalgias, and disseminated endothelial infection. Immune responses to Rickettsia and pathogenesis of rickettsioses are not fully understood. Current work with Rickettsia is limited to vertebrate models that are strictly regulated and have low throughput. Since the innate immune system of vertebrates retains striking similarities with the immune response in insects, invertebrates are being used to study host responses to various pathogens. The purpose of this study was to evaluate if larvae of the greater wax moth Galleria mellonella (GML) can be used as an …

Ashes To Ashes—The Coronavirus, Ebola, And The Erosion Of Liberty And Property Interests In The Fight Against Communicable Diseases, Casey C. Dereus

Louisiana Law Review

The article examines how national and state governments in the U.S. are exercising their authority to stop the spread of communicable diseases like COVID-19 and Ebola and their impacts on the rights of physical liberty and property rights of Americans.

The New Hampshire, Vol. 110 [111], No. 57 (Apr. 29, 2021), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 110, but it is the 111th volume in the series. This was corrected in pencil.

Comprehensive In Silico Analysis Of Christinin Molecular Behaviour From Ziziphus Spina-Christi Leaves On Propionibacterium Acnes, Fitrianti Darusman, Taufik Muhammad Fakih

Pharmaceutical Sciences and Research

The role of in silico studies in the discovery of new drugs is very important and interesting in the recent years, where the results can be used as confirmation of the results of in vitro tests carried out experimentally in the laboratory. One of the herbal ingredients is Ziziphus spina-christi leaves with effective antibacterial activity, such as for acne-causing bacteria, namely Propionibacterium acnes. This is because it contains main secondary metabolites with saponins as the major components which contain christinin as its active compound. There are four known types of christinin, namely christinin-A, christinin-B, christinin-C, and christinin-D. In this …

Surveying Pediatric Caregivers’ Readiness For Dyad Isolation In The Hospital During Covid-19, Shanqing Yin, Mei Zi Quek, Celestine Mun Ting Yeo, Sylvia Mun, Ronghui Li, Derrick Chan

Patient Experience Journal

The onset of any emerging outbreak is stressful for everyone. Singapore was one of many countries affected early by COVID-19. In response, many precautionary measures were quickly initiated, including the isolation of suspected COVID-19 pediatric cases, and their caregivers were isolated together with their hospitalized children as a result. Caregivers play an important role in facilitating their child’s health in the hospital. Rooming in with their children during hospitalization promotes the benefits of parental presence and reduces separation effects. However, sudden admission with strict movement restrictions poses stress to these caregivers too. This study ran a 3-part paper-based survey to …

Student Pages - You Are The Phi, Center For Urban Resilience

Module 05: Public Health & Water Quality

In this activity, you are playing the role of a Public Health Investigator (PHI) assigned to a case. In your city, there has been a recent outbreak of sickness that is affecting dozens of people. The doctors report that the illness is caused by a bacterial infection. All of these people have reported a similar illness over the past 24 hours. They have reported nausea, diarrhea, fever and chills. However, the infection is generally not transferable from person-to-person. Therefore, people who are sickened by the bacteria must be acquiring the infection from a source.

Student Pages - Answer Key - You Are The Phi, Center For Urban Resilience

Module 05: Public Health & Water Quality

No abstract provided.

Drug Repurposing And Dosage Form Development Of Anti-Covid-19, Kevin Kwok

Pharmaceutical Sciences and Research

The COVID-19 pandemic has been occurring approximately for more than 1 year. This pandemic has been a health issue that hits all countries in the world caused by the transmission of SARS-CoV-2 virus from one individual to another. The symptoms showed from the infected are fever, shortness of breath, dry cough, headache, and sore throat, among others. The SARS-CoV-2 virus is transmitted through sneezing, coughing, talking, and touching infected objects. Along with this transmission, the SARS-CoV-2 virus will continue to mutate. This mutation becomes an obstacle as well as a challenge to find drugs that can overcome the SARS-CoV-2 virus …

2021-04-28_Michiganoverview_Covidtestingtimes, Michigan Department Of Health & Human Services

Michigan COVID-19 Testing Turnaround Data

The COVID Testing Turnaround Time page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-545615--,00.html.

This report was created by the Michigan Department of Health & Human Services, providing data for the past 14 days on the average time it takes for a diagnostic COVID-19 laboratory test to be reported to the state health department. Testing turnaround time data will be updated weekly on Friday mornings.

MDHHS receives results from commercial labs, hospitals, and public health labs. However, public health laboratories perform limited diagnostic testing and disease surveillance for infectious diseases. Total turnaround time is calculated from the difference of …

More Than Brides Alliance: Endline Evaluation Report, Andrea J. Melnikas, Grace Saul, Michelle Chau, Neelanjana Pandey, James Mkandawire, Mouhamadou Gueye, Aissa Diarra, Sajeda Amin

Poverty, Gender, and Youth

This endline report presents findings from the More Than Brides Alliance’s (MTBA) project “Marriage: No Child’s Play” (MNCP) carried out in four countries: India, Malawi, Mali, and Niger. The MTBA project sought to empower girls, raise awareness about the risks of child marriage, improve girls’ access to sexual and reproductive health services, and support social norms favorable to girls’ education, economic engagement, and agency in marital decision-making. Results are presented from the MNCP evaluation, including over the final year, which was characterized by significant adaptations in programming and research due to Covid-19. This report explores behavioral outcomes related to child …

Uab Experts: We Need More Alabamians To Receive Covid Vaccine To Safely Return To Normal, Tyler Greer

Browse All News

No abstract provided.

Daily Eastern News: April 28, 2021, Eastern Illinois University

April

No abstract provided.

Hypertension As A Sequela In Patients Of Sars-Cov-2 Infection., Ganxiao Chen, Xun Li, Zuojiong Gong, Hao Xia, Yao Wang, Xuefen Wang, Yan Huang, Hector Barajas-Martinez, Dan Hu

Department of Medicine Faculty Papers

BACKGROUND: COVID-19 is a respiratory infectious disease caused by SARS-CoV-2, and cardiovascular damage is commonly observed in affected patients. We sought to investigate the effect of SARS-CoV-2 infection on cardiac injury and hypertension during the current coronavirus pandemic.

STUDY DESIGN AND METHODS: The clinical data of 366 hospitalized COVID-19-confirmed patients were analyzed. The clinical signs and laboratory findings were extracted from electronic medical records. Two independent, experienced clinicians reviewed and analyzed the data.

RESULTS: Cardiac injury was found in 11.19% (30/268) of enrolled patients. 93.33% (28/30) of cardiac injury cases were in the severe group. The laboratory findings indicated that …

The Hidden Safety Net: Wild And Semi-Wild Plant Consumption And Nutrition Among Women Farmers In Southwestern Burkina Faso, Jane Servin

Geography Honors Projects

Mainstream development thinking suggests that increasing agricultural production will increase wealth and lead to improved diets. However, this perspective does not account for the complexities of food access, gender, and household dynamics. In Burkina Faso, development initiatives focus on increasing agricultural yield to alleviate hunger, but relatively wealthy areas are still experiencing widespread food insecurity. Wild plants play a key role in rural diets and serve as a nutritional safety net. This research investigates the use of wild plants for nutrition among women rice farmers and their households in Southwestern Burkina Faso. I examine the connections between native plant consumption, …