Digital Commons Network^™

Clinical Consequences And Determinants Of False Positive Blood Cultures In Adult Hospitalized Patients, Sidra Liaquat

Theses & Dissertations

Blood cultures are the gold standard for detecting blood stream infections. However, in the US, 0.6-6% of all blood cultures get contaminated leading to adverse clinical outcomes such as unnecessarily prolonged hospital stay and antibiotic therapy. Using electronic medical records, we explored the clinical outcomes and patient-specific risk factors of contaminated blood cultures in an era where rapid blood culture testing was being utilized to provide blood culture results within hours. Rapid blood culture test results can help clinicians in early and more effective management of patients with contaminated blood cultures, thus improving clinical outcomes. We also studied the impact …

Fire Service Covid-19 Infection Prevention And Control Policy Comparison, Saaddedine Dichari

Theses & Dissertations

To date, there have been over 2.7 million deaths and more than 126 million cases attributed to the COVID-19 pandemic (JHU, 2021). This pandemic has affected nearly every aspect of daily life. Among those impacted are U.S. firefighters, as they provide many services beyond simply extinguishing structure fires and are frequently dual certified as emergency medical technicians. Many of the victims of this pandemic have relied on first responders to provide them with emergency medical care and hospital transport. When caring for these infected patients, firefighters have an increased risk of exposure and must be provided with adequate …

Marinopyrrole Derivatives As Putative Antiparasitic Molecules Promoting Initiation Of Programmed Cell Death In Toxoplasma Gondii, Matthew C. Martens

Theses & Dissertations

Toxoplasma gondii is a globally-distributed obligate intracellular parasite and the causative agent of toxoplasmosis in humans, a biphasic disease often culminating in lifelong chronic infection. Though often mild, toxoplasmosis can lead to severe clinical presentation in immunocompromised patients and developing fetuses. Current therapeutic options are severely limited, with a combinatorial pyrimethamine/sulfadiazine regimen acting as the current standard of care for toxoplasmosis; however, both of these compounds can elicit serious adverse reactions in patients, and, additionally, are only effective against the acute stage of infection. To address these limitations, screenings of several analogs derived from the marine natural product marinopyrrole A …

The Political Pandemic: Investigating The Relationship Between Political Ideology And Covid-19 Compliance, Allison Moore

Undergraduate Theses

One key to curtailing the health costs of COVID-19 is adherence to social distancing measures. Despite their importance, distancing measures seem to have proved divisive. The present research sought to identify ideological differences in behavioral compliance to distancing measures and to account for the psychological underpinnings of behavioral differences. A first study (April, 2020; N=571) using Amazon’s Mechanical Turk revealed conservatives to be significantly less likely to obey social distancing recommendations than liberals. Differences among conservatives and liberals in adherence to self-reported social distancing practices were significantly mediated by perceived COVID-19 health risk and perceived media accuracy in covering the …

In Utero And Postnatal Oxycodone Exposure: Implications For Intergenerational Effects, Katherine E. Odegaard

Theses & Dissertations

Prescription opioid abuse during and after pregnancy is a rising public health concern. Adding a layer of complexity is the role of heredity in the overall development of these exposed offspring. The present work uses a preclinical rat model mimicking oxycodone (oxy) exposure in utero (IUO) and postnatally (PNO) to investigate comparative and intergenerational effects in the two different exposure groups.

To understand the direct effects of IUO and PNO exposure on the F1 generation, we employed a systems biology approach encompassing proton magnetic resonance spectroscopy (¹H-MRS), electrophysiology RNA-sequencing, and pain assessment to elucidate molecular and behavioral changes …

Development Of Long-Acting Antiviral Drug Nanoformulations, Denise Cobb

Theses & Dissertations

Antiretroviral therapy (ART) has improved the quality and duration of life for people living with human immunodeficiency virus (HIV) infection. However, opportunities to improve its profile abound. ART is limited by putative viral reservoir penetrance, emergence of viral mutations, inherent toxicities, and regimen non-adherence. These highlight the need improved drug delivery schemes. Previously, our lab has demonstrated that targeting mononuclear phagocytes for antiretroviral drug delivery extends drug half-life and improves penetrance into viral reservoirs, addressing these limitations of ART. Herein, we developed synthetic and biologic antiretroviral (ARV) drug nanocarriers improve the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of ARVs through …

Characterization Of Di-Aryl Urea Compounds Against Acute And Chronic Toxoplasma Gondii, Austin Sanford

Theses & Dissertations

Toxoplasma gondii is an obligate intracellular parasite that has infected nearly 60 million individuals in the United States alone. Acute infection causes ill effects to the fetus in utero when mothers are primarily infected, and to immunocompromised individuals. Chronic infection consists of quiescent tissue cysts located primarily in brain tissue and is capable of reverting back to the acute stage causing severe toxoplasma encephalitis in immunocompromised individuals. Current treatments for acute infection are lacking while there are no approved treatments for the clearance of chronic infection. The aim of this research was to evaluate a family of di-aryl urea compounds …

Long-Term Mortality After Histoplasma Infection In People With Hiv, Joseph Cherabie, Patrick Mazi, Adriana M Rauseo, Chapelle Ayres, Lindsey Larson, Sasinuch Rutjanawech, Jane O'Halloran, Rachel Presti, William G Powderly, Andrej Spec

2020-Current year OA Pubs

Histoplasmosis is a common opportunistic infection in people with HIV (PWH); however, no study has looked at factors associated with the long-term mortality of histoplasmosis in PWH. We conducted a single-center retrospective study on the long-term mortality of PWH diagnosed with histoplasmosis between 2002 and 2017. Patients were categorized into three groups based on length of survival after diagnosis: early mortality (death < 90 days), late mortality (death ≥ 90 days), and long-term survivors. Patients diagnosed during or after 2008 were considered part of the modern antiretroviral therapy (ART) era. Insurance type (private vs. public) was a surrogate indicator of socioeconomic status. Out of 54 PWH infected with histoplasmosis, overall mortality was 37%; 14.8% early mortality and 22.2% late mortality. There was no statistically significant difference in survival based on the availability of modern ART (

2021-05-07_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Lab Home Testing Of Residential Isolation Space Control To Minimize Infectious Disease Transmission In Existing Single-Family Homes - Fact Sheet, Florida Solar Energy Center, Tanvir Khan

FSEC Energy Research Center®

The FSEC Energy Research Center at the University of Central Florida performed research to test the effectiveness of interventions to isolate an ill person recovering from a contagious disease in a single-family home from the rest of the occupants in the home. Focus was placed on interventions requiring minor cost and effort on the part of the occupants.

DOE/GO-102021-5537, https://www.nrel.gov/docs/fy21osti/79519.pdf

Codon Bias Can Determine Sorting Of A Potassium Channel Protein, Anja J. Engel, Marina Kithil, Markus Langhans, Oliver Rauh, Matea Cartolano, James L. Van Etten, Anna Moroni, Gerhard Thiel

Nebraska Center for Virology: Faculty Publications

Due to the redundancy of the genetic code most amino acids are encoded by multiple synonymous codons. It has been proposed that a biased frequency of synonymous codons can affect the function of proteins by modulating distinct steps in transcription, translation and folding. Here, we use two similar prototype K⁺ channels as model systems to examine whether codon choice has an impact on protein sorting. By monitoring transient expression of GFP-tagged channels in mammalian cells, we find that one of the two channels is sorted in a codon and cell cycle-dependent manner either to mitochondria or the secretory pathway. …

Remembering A Hidden Space: Stitching Memorial Architecture With A Subterranean Tunnel System Of The Slave Trade, Olivia Harrell

Bachelor of Architecture Theses - 5th Year

To my ancestors. Imagine the British raiding your homeland in the middle of the night… being taken away from your family all to be taken to the dungeons of Cape Coast Castle…being forced on a dark ship, stacked on top of another flesh, praying to God to survive the long voyage. Gracefully, you reach landfall, only to be examined and sorted, to have your last name stripped away from you…seeing the sick woman that lied next you on the voyage, be dumped into the Atlantic Ocean and left to drown…being forced to build the underground barracks, that you would live …

Explaining Reproductive Health Disparities: Violence In The “Colorblind” Institution Of Medicine, Chineze Osakwe

Honors Scholar Theses

Medical policies have resulted in violence that has a formal role in regulating the reproductive rights of women of African descent in the United States from the Jim Crow era (circa 1965) to present day (2021), resulting in significantly racialized reproductive health disparities regardless of social or economic influences. This thesis explores why reproductive violence against African-American women persists, regardless of women’s own class and educational background. I have focused on the potential impact of two structural components that I hypothesized contributed to the perpetuation of reproductive violence against Black women and persistent health disparities. The two factors explored in …

Professional Ethics For College Health Services, Dessa Mrvos

Electronic Theses and Dissertations

College health services provide a crucial resource for campus communities in the United States, substantially affecting student health, safety, and wellbeing. The impact and quality of campus clinical services impact student life through varied approaches to the delivery of services, health innovations, and business models. The role that campus health services plays in dealing with risk mitigation is essential: well-established public health principles of disease prevention, health promotion, and health education are sustained and advanced by campus clinical health services. Despite the widely recognized importance of college health services, there is very little literature on the contribution of ethics related …

Provider Knowledge Of Tickborne Diseases, Kristi Harbit

Doctor of Nursing Practice Scholarly Project

Tickborne diseases have increased in incidence in recent years, and new tickborne diseases are being discovered. These increasing numbers show the importance of well-educated health care providers to adequately diagnose and treat these diseases. The purpose of this DNP scholarly project study was to determine the effectiveness of an educational presentation for primary care providers over tickborne diseases in Kansas, Missouri, Oklahoma, and Arkansas. The educational presentation was given at a local nurse practitioner conference and knowledge was assessed via a pre-test, post-test, and 6-week follow-up email. Few research articles are available over this subject and the articles that have …

Molecular Detection Of Pathogenic Leptospira And Microbial Source Tracking Of Fecal Pollution In San Juan, Puerto Rico, Taylor I. Chapman

Biology Theses

Leptospirosis, caused by pathogenic Leptospira, is endemic to tropical regions. Leptospira is released into the environment through the secretion of urine from animals, making it easily transmissible through water sources. The estuarian environment surrounding the area of San Juan, Puerto Rico and its high density of urban development creates ideal conditions for transmission of Leptospirosis. The goal of this study was to determine the presence of Leptospira in these surface waters and use Microbial Source Tracking (MST) to identify the possible source of pathogenic Leptospira. Eighty-seven water samples were collected during the dry (44) and wet (43) seasons. …

Addressing Climate Induced Displacement: An Analysis Of Protection Policies For Environmental Migrants, Meredith R. Lawing

Senior Honors Projects, 2020-current

One of the fastest growing populations of displaced people are those forced to migrate because of climate change, but under current international legal agreements they receive no protections or support. In response to the lack of security and stability provided to climate displaced populations and host countries, supplementary agreements have been proposed at the international level to address the gaps in existing policy. The purpose of this analysis is to identify policy agreements intended to support environmental migrants during times of displacement, evaluate the policies’ effectiveness, and determine what issues they address regarding climate induced displacement. All of the policies …

Medical Volunteers During Pandemics, Disasters, And Other Emergencies: Management Best Practices, John I. Winn, Seth Chatfield, Kevin H. Govern

Seattle Journal of Technology, Environmental, & Innovation Law

How best to utilize volunteers^[1] during medical emergencies is an essential part of hospital compliance planning. Onboarding recruited and spontaneous volunteers during crisis situations require careful consideration of multiple legal issues. Volunteer planning becomes more complex if volunteers move across state lines because applicable tort immunity statutes,^[2] compensation limits,^[3]and workers compensation regimes vary significantly from one jurisdiction to another. Effective planning for volunteers requires these and other issues to be addressed well in advance of actual emergencies. Although predicting the scope or severity of any future crisis is impossible, the provided checklist of management best practices …

Free Willy: A Breach To Rejuvenate The Southern Resident Killer Whale, Luke Mcdonough

Seattle Journal of Technology, Environmental, & Innovation Law

State and federal government entities have made great strides in environmental protection since the inception of the Environmental Protection Agency and the enactment of major environmental regulations. However, species worldwide continue to face threats of extinction due to human activity and climate change without prompt, major intervention. In Washington state, the iconic Southern Resident Killer Whale has seen a dramatic decrease in population since the 1960s. Protections directed for their benefit have not provided the expected return as the main challenges Southern Residents face remain largely unresolved. To restore the Southern Residents’ population for future generations, their entire ecosystem must …

Medkit: Modular Emergency Deployment, Christian Ladefoged, Zamila Karimi

Bachelor of Architecture Theses - 5th Year

This thesis began with exploring low-cost prefab dwelling units to be implemented in struggling communities with extreme poverty, homelessness, and unemployment. The initial research on modular units shifted to focus on our healthcare infrastructure challenges here at home given the COVID-19 crisis.

“Coronavirus disease 2019 (COVID-19) has had a substantial impact on racial and ethnic minority populations and essential workers in the United States …”¹ This disease disproportionately impacts poor and rural communities in the United States, showing double the mortality than urban areas simply due to the neglected environment². Emergency assistance is needed to expand the …

Lab Home Testing Of Residential Isolation Space Control To Minimize Infectious Disease Transmission In Existing Single-Family Homes, Florida Solar Energy Center, Tanvir Khan

FSEC Energy Research Center®

Existing evidence strongly suggests that viral infectious diseases can be transmitted via an airborne route across distances in indoor environments. Accordingly, the risk of airborne transmission within homes should be managed. The public health emergency associated with SARS-CoV-2 makes controlling airborne transmission of respired viruses in indoor environments critical, especially in poorly ventilated indoor environments. The effectiveness of engineering interventions requiring minor efforts that create a negative-pressure isolation zone (IZ) for a contagious person has yet to be tested for existing residential homes.

To mitigate the risk of airborne virus transmission and maximize health protection for the population in existing …

Increasing Patient Access To Medication-Assisted Treatment Programs For Opioid Use Disorder, Matthew J. Bednarchik

Doctor of Nursing Practice Projects

The project sought to explore the perceived need for Medication-Assisted Treatment (MAT) for opioid use disorder among primary care providers in a rural central Illinois county. This project’s primary goal was to measure the prevalence of OUD in the community and the likelihood of primary care providers referring to an outpatient MAT program. A secondary objective was to utilize the survey results as a tool for the development of a MAT program. A cohort of twenty-five primary care providers were invited to participate in a survey to assess the perceived prevalence of OUD as well as the need for increased …

Five Benefits Of Getting A Covid-19 Vaccine, Brianna Hoge

Browse All News

No abstract provided.

Constructing The Panama Canal: A Brief History, Ian E. Phillips

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

Seeking to commemorate the construction of the Panama Canal, an engineering marvel widely considered a contender for the eighth wonder of the world, this article attempts to retell the story of the Canal's construction by synthesizing a narrative centered on the Canal under French and American leadership, worker segregation, and labor conditions at the Isthmus.

Notes On The Medical History Of Key West, 1822-1832, E. Ashby Hammond

Florida Historical Quarterly

The years 1818 to 1823 were unquiet times in the northern Caribbean. The Latin nations of the area were either stabilizing their newly gained independence or preparing for further expressions of defiance against their Iberian overlords. In any event there was neither time nor the resources for organizing a military patrol of the waters extending from Venezuela to Tampa Bay, from Yucatan to Puerto Rico. Piracy was virtually unrestrained, and wrecking, considered by some observers to have been an only slightly more honorable enterprise, went unregulated. Shortly after John W. Simonton had acquired the island, then known as Cayo Hueso, …

Comparing The Health And Welfare Of Refugees And Non-Refugees At The Outset Of The Covid-19 Pandemic: The Results Of A Community Needs Assessment., Matthew J. Lyons, Mary Helen O'Connor, Iris Feinberg, Daniel J. Whitaker, Michael Eriksen, Ashli Owen-Smith, Saiza Jivani, Mohammad Tamer, Esther Kim, Ganaro Makor

Journal of Refugee & Global Health

Refugees are a vulnerable population who experience significant health disparities. They may also be at disproportionately high risk of adverse outcomes due to the COVID-19 pandemic. This paper presents the results of a community needs assessment to investigate the impact of the pandemic on health and welfare in a refugee relocation community in the United States. A multilingual data collection team made up of refugees surveyed 179 participants (128 refugees vs. 51 non-refugees). Only 55.9% of refugee respondents said they would be able to provide enough food for their family this week, compared with 84.0% of non-refugees (p < 0.01), and this difference was even greater for food next week …

Rheumatoid Nodule Mimicker Mycobacterium Haemophilum: A Case Presentation, Elisa Griswold

Rowan-Virtua Research Day

Mycobacterium haemophilum is a rare infection that can present in humans as subcutaneous nodules and cutaneous lesions. With a growing number of immunocompromised patients, M. haemophilum infections are becoming more common. Rheumatoid nodules in comparison are very common and can occur in approximately 25% of patients with Rheumatoid Arthritis (RA). Here we discuss a case in a patient with Rheumatoid Arthritis who developed subcutaneous nodules that mimicked rheumatoid nodules, but were later determined to be infectious nodules from Mycobacterium haemophilum.

The Politics Of Public Budgeting In Illinois (Second Edition), John Jackson, John Foster

The Simon Review (Occasional Papers of the Paul Simon Public Policy Institute)

This paper is about taxing, revenue, and public budgeting in Illinois. The concept of public budgeting includes both the revenues raised by government and the ways in which those revenues are spent on the functions and programs sponsored by governments. This paper focuses especially on spending, that is, on how and where revenue is distributed in the state in the form of public services and programs. It provides relevant data on the statewide distribution patterns and especially the question of whether those expenditures of the tax-payers’ money disproportionately benefit one region over the other. This question has provoked a long …

Time Series Forecasting Of Covid-19 Deaths In Massachusetts, Andrew Disher

Honors Program Theses and Projects

The aim of this study was to use data provided by the Department of Public Health in the state of Massachusetts on its online dashboard to produce a time series model to accurately forecast the number of new confirmed deaths that have resulted from the spread of CoViD-19. Multiple different time series models were created, which can be classified as either an Auto-Regressive Integrated Moving Average (ARIMA) model or a Regression Model with ARIMA Errors. Two ARIMA models were created to provide a baseline forecasting performance for comparison with the Regression Model with ARIMA Errors, which used the number of …

Retinal Vasculitis: A Case Study, Peter Maduka, Sarah G. Bonaffini, Naman Shah, Deepika Malik

Rowan-Virtua Research Day

Purpose: To describe a case of idiopathic retinal vasculitis.

Methods: Case report and literature review.

Case: A healthy 25-year-old female presented with a one-week history of a large floater in her right eye. Patient’s subjective complaint of floaters, including the scotoma on VF and the FA findings were most consistent with retinal vasculitis displaying predominant venous involvement. However, findings for acute macular neuroretinopathy and multiple evanescent white dot syndrome (MEWDS) were present as well. Autoimmune and infectious disease panels were negative. Neuro consult and brain MRI showed nonspecific, non contributory findings. Several weeks later, following Medrol dose pack, patient reported …