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Articles 2431 - 2460 of 5609
Full-Text Articles in Entire DC Network
Temperature Effects On Prevalence Of Sexually Transmitted Infections Among At-Risk Female Sex Workers In India, Rajshri Suresh
Temperature Effects On Prevalence Of Sexually Transmitted Infections Among At-Risk Female Sex Workers In India, Rajshri Suresh
Master's Theses
Vulnerability to climate change varies depending on the baseline climate, sensitivity to given exposure, and the presence of social, political, cultural, and institutional inequalities that influence access to essential resources of livelihood, particularly among informal labor market participants. Within the risky informal labor market, the transient nature of sex work implies that sex workers suffer disproportional losses in health, income, protection, and other aspects of general well-being as a result of the effects of climate anomalies. In this paper, I investigate the effect of temperature on the prevalence of sexually transmitted infections in a high-risk population of female sex workers …
The Role Of Comorbidities And Social Determinants Of Health In Patients With Covid-19 In New Mexico, Lauren Epler, Tenzin Desel, Ariana Thompson, Samantha Paltrow-Krulwich, Susie Pham, Diamone Gathers Md, Krystal Chan Md
The Role Of Comorbidities And Social Determinants Of Health In Patients With Covid-19 In New Mexico, Lauren Epler, Tenzin Desel, Ariana Thompson, Samantha Paltrow-Krulwich, Susie Pham, Diamone Gathers Md, Krystal Chan Md
Quality Improvement/Patient Safety Symposium
Introduction
Comorbidities are associated with higher levels of morbidity and mortality in patients with COVID-19 infection. Minorities have been disproportionately affected by COVID-19. Additionally, minorities have high rates of comorbidities.
Methods
Students surveyed consented patients on RedCap who tested positive for COVID-19 infection and were seen in the UNM COVID-Follow up Clinic between April-October 2020 via telephone.
Results
125 patients. 52% Hispanic/Latino, 23% American Indian/Alaska Native, 16% white, 3% African American, 1% Asian, and 5% multiple race/ethnicities. 16% had vaped nicotine, 15% had vaped marijuana or cannabis, and 33% had smoked at least 100 cigarettes in their lifetime. 23% had …
Anal Cancer Screening At Truman Health Services, Peter D. Tran, Harshdeep Babbar
Anal Cancer Screening At Truman Health Services, Peter D. Tran, Harshdeep Babbar
Quality Improvement/Patient Safety Symposium
Anal Papanicoloau Screening at Truman Clinic
Anal cancer is a squamous cell cancer associated with human papillomavirus (HPV), the same virus that is associated with cervical cancer. Although vaccination against HPV has been shown to be effective in reducing overall rates of infection, the number of new anal cancer cases has been rising for many years. In HIV-infected men and women, the incidence is even higher of anal cancer than in the general population. Current rates in an HIV-infected MSM population have been estimated to be as high as 70-144 per 100,000, with some studies of HIV-infected individuals showing that …
The Effect Of State Level Covid-19 Stay-At-Home Orders On Death Rates, Stephen A. Langeland, Jose Marte, Kyle Connif
The Effect Of State Level Covid-19 Stay-At-Home Orders On Death Rates, Stephen A. Langeland, Jose Marte, Kyle Connif
Helm's School of Government Conference - 2021-2024
This paper attempts to examine a correlation between lockdown length and COVID-19 case rate, death rate and fatality rate. In March of 2020, the publishing of alarmist epidemiological models prompted government officials to enact sweeping emergency measures (Miltimore 2020). Notably, the Imperial College London model published by epidemiologist Neil Ferguson predicted a “best-case scenario” of 1.1 million COVID-19 deaths in the U.S. by August 2020. This model heightened concern that the hospital system would be overwhelmed, a reason cited by President Trump’s Coronavirus Task Force members, Dr. Birx and Dr. Fauci, as justification for the “15 Days to Flatten the …
May 20, 2021: Covid-19 Campus Update, Kettering University
May 20, 2021: Covid-19 Campus Update, Kettering University
Communication Updates
Topics in this Update:
Updated Safety Guidelines
Commencement
Free Vaccination Clinics
The Role Of Climate Change, Wildfire And Human Interference In The Potential Spread Of Sin Nombre Hantavirus In North America, Margarita Miglio
The Role Of Climate Change, Wildfire And Human Interference In The Potential Spread Of Sin Nombre Hantavirus In North America, Margarita Miglio
Master's Projects and Capstones
Sin Nombre hantavirus is a rare rodent-borne pathogen that causes Hantavirus Cardiopulmonary Syndrome (HCPS), a disease with a 35% fatality rate in humans. The main rodent host of Sin Nombre hantavirus is the deer mouse (Peromyscus maniculatus), one of the most prolific, best studied and highly adaptable rodent species in North America. Deer mice are hyper-reservoirs, carrying Sin Nombre virus, plague (Yersinia pestis) and the Peromyscus species carry Lyme disease. Although deer mice have been shown to react positively to wildfire, current assessments of Sin Nombre hantavirus risk to humans and climate change do not consider …
Microbial Evolution Of Cryosphere And Biosecurity Concerns, Jingyang Xu, Qianggong Zhang, Yi Shi
Microbial Evolution Of Cryosphere And Biosecurity Concerns, Jingyang Xu, Qianggong Zhang, Yi Shi
Bulletin of Chinese Academy of Sciences (Chinese Version)
The unique and extreme ecological environment of cryosphere acts as a gigantic reservoir of microorganisms, which preserves precious records of the diversity and evolutionary history of ancient microbes. Climate change and human activities have made significant impacts on the ecological system. Global warming causes melting of the cryosphere that remained frozen for thousands of years and releases microorganisms, some of them are recovered to life and constitute a potential threat to the ecological environment and human health. It is urgent to combine multidisciplinary research forces to investigate the microbial ecology of cryosphere, analyze the microbe pathogenesis and transmission mechanisms, as …
O'Neal Comprehensive Cancer Center, Other Top U.S. Cancer Centers Call For Urgent Action To Get Cancer-Preventing Hpv Vaccination Back On Track, Tyler Greer
Browse All News
No abstract provided.
Improving Surface Cleaning And Hand Hygiene Using Fluorescent Markers, Taryn Whitman
Improving Surface Cleaning And Hand Hygiene Using Fluorescent Markers, Taryn Whitman
Master's Projects and Capstones
Problem: Compared to inpatient units, ambulatory care clinics have differences in staffing available and frequency to perform room turnover (RTO). Pre-intervention data revealed poor Hand hygiene (HH) and high-touch surface cleaning (HTSC) knowledge and low RTO compliance reliability. Currently, there is no process for objectively monitoring RTO compliance and staff self-evaluation of HH, HTSC, and RTO performance is incongruent with observations.
Context: HH and HTSC are a crucial component of preventing healthcare-associated infections (HAIs). Estimated loss of revenue for one northern California tertiary university hospital system (HCO) campus was nearly $1.8 million dollars in Medicare penalties for 2018.
Intervention: …
Thermochemistry Of Combustion In Polyvinyl Alcohol + Hydroxylammonium Nitrate, James K. Baird, Robert A. Frederick Jr.
Thermochemistry Of Combustion In Polyvinyl Alcohol + Hydroxylammonium Nitrate, James K. Baird, Robert A. Frederick Jr.
PRC-Affiliated Research
A mixture of polyvinyl alcohol (PVA) and hydroxylammoniun nitrate (HAN) forms a gummy solid known as a plastisol, which is ionically conducting. When an electrostatic potential of 200 V DC is applied across the plastisol, it ignites. Combustion ceases upon removal of the applied voltage. The products of PVA + HAN combustion are known to include the molecular gases carbon monoxide, carbon dioxide, water, nitrogen, and hydrogen. When the electric field within the plastisol is spatially uniform, combustion occurs preferentially at the anode. The fact that HAN is an ionic conductor suggests that the mechanism of combustion is electrolytic in …
Thermochemistry Of Combustion In Polyvinyl Alcohol + Hydroxylammonium Nitrate, James K. Baird, Robert A. Frederick Jr.
Thermochemistry Of Combustion In Polyvinyl Alcohol + Hydroxylammonium Nitrate, James K. Baird, Robert A. Frederick Jr.
PRC-Affiliated Research
A mixture of polyvinyl alcohol (PVA) and hydroxylammoniun nitrate (HAN) forms a gummy solid known as a plastisol, which is ionically conducting. When an electrostatic potential of 200 V DC is applied across the plastisol, it ignites. Combustion ceases upon removal of the applied voltage. The products of PVA + HAN combustion are known to include the molecular gases carbon monoxide, carbon dioxide, water, nitrogen, and hydrogen. When the electric field within the plastisol is spatially uniform, combustion occurs preferentially at the anode. The fact that HAN is an ionic conductor suggests that the mechanism of combustion is electrolytic in …
Utilizing Tracer Methodology To Evaluate The Effectiveness Of A Hospital Antimicrobial Stewardship Program, Christine Smyth
Utilizing Tracer Methodology To Evaluate The Effectiveness Of A Hospital Antimicrobial Stewardship Program, Christine Smyth
Doctor of Nursing Practice (DNP) Projects
Antimicrobial resistant organisms are a growing threat in the United States and globally. It has become the expectation that healthcare institutions, including hospitals, contribute resources to create and maintain antimicrobial stewardship programs to decrease antimicrobial resistance, improve patient outcomes, and decrease the spread of multi-drug resistant organisms. The methods utilized to evaluate antimicrobial stewardship at hospitals often only evaluate outcome measures and fail to capture knowledge of the hospital antimicrobial stewardship program among prescribers, clinical pharmacists, and nurses, as well potential barriers to antimicrobial stewardship among healthcare providers. The purpose of this Doctor of Nursing project is to implement and …
Covid-19, Lying, Mask-Less Exposures And Disability During A Pandemic, Madeleine M. Plasencia
Covid-19, Lying, Mask-Less Exposures And Disability During A Pandemic, Madeleine M. Plasencia
University of Miami Race & Social Justice Law Review
This article focuses on disability law in the context of COVID-19. In dealing with this pandemic, businesses, schools and other covered entities have to navigate and manage (at least) three different categories of people congregating. First are those who act as if there were no pandemic at all; they simply do not care if they are contagious and insist upon not complying with safety precautions, such as mask-wearing and social distancing; second are people who have medical conditions that make them especially vulnerable and at high-risk for severe symptoms associated with the infection; third are people who have already contracted …
Wicked Problems: Understanding How Cities And Counties In California Are Tackling Climate Change And Homelessness, Guadalupe Michelle Franco
Wicked Problems: Understanding How Cities And Counties In California Are Tackling Climate Change And Homelessness, Guadalupe Michelle Franco
Master's Theses
California continues to endure the detrimental effects of climate change, such as poor air quality, flooding, and heatwaves. Concurrently, the state has seen an increase in the number of unhoused communities due to various ramifications such as rapid urbanization, failed political leadership, and restricted housing policies. While unhoused communities fight to access basic services, they must also now adapt to the looming impacts of climate change. Unhoused populations are especially vulnerable to climate change as they have limited access to shelter, spend the majority of their time outdoors, and lack the economic ability to adapt. While cities and counties are …
Analysis Of Gaps In Feline Ectoparasiticide Purchases From Veterinary Clinics In The United States, Robert Lavan, Dorothy Normile, Imran Husain, Amita Singh, Kathleen Heaney
Analysis Of Gaps In Feline Ectoparasiticide Purchases From Veterinary Clinics In The United States, Robert Lavan, Dorothy Normile, Imran Husain, Amita Singh, Kathleen Heaney
Publications and Research
Background: The study objective was to examine cat owner ectoparasiticide purchases in the United States and estimate the impact of purchase gaps on timely ectoparasite protection administration. These purchase gaps lead to periods of time when cats are unprotected from ectoparasites.
Methods: Ectoparasiticide purchase transactions for individual cats from 671 U.S. veterinary clinics from January 1, 2017 through June 30, 2019 were evaluated to determine time “gaps” between doses of ectoparasiticides purchased in a defined 12-month period. Ectoparasiticides examined were topically applied products that contained fluralaner, fipronil/(S)-methoprene/pyriproxyfen, imidacloprid/pyriproxyfen or selamectin as active ingredients. The duration of protection following administration of …
Resistance To Lethal Ectromelia Virus Infection Requires Type I Interferon Receptor In Natural Killer Cells And Monocytes But Not In Adaptive Immune Or Parenchymal Cells., Carolina R Melo-Silva, Pedro Alves-Peixoto, Natasha Heath, Lingjuan Tang, Brian Montoya, Cory J Knudson, Colby Stotesbury, Maria Ferez, Eric B. Wong, Luis J. Sigal
Resistance To Lethal Ectromelia Virus Infection Requires Type I Interferon Receptor In Natural Killer Cells And Monocytes But Not In Adaptive Immune Or Parenchymal Cells., Carolina R Melo-Silva, Pedro Alves-Peixoto, Natasha Heath, Lingjuan Tang, Brian Montoya, Cory J Knudson, Colby Stotesbury, Maria Ferez, Eric B. Wong, Luis J. Sigal
Department of Microbiology and Immunology Faculty Papers
Type I interferons (IFN-I) are antiviral cytokines that signal through the ubiquitous IFN-I receptor (IFNAR). Following footpad infection with ectromelia virus (ECTV), a mouse-specific pathogen, C57BL/6 (B6) mice survive without disease, while B6 mice broadly deficient in IFNAR succumb rapidly. We now show that for survival to ECTV, only hematopoietic cells require IFNAR expression. Survival to ECTV specifically requires IFNAR in both natural killer (NK) cells and monocytes. However, intrinsic IFNAR signaling is not essential for adaptive immune cell responses or to directly protect non-hematopoietic cells such as hepatocytes, which are principal ECTV targets. Mechanistically, IFNAR-deficient NK cells have reduced …
Thoughts On Systematic Layout Of Strengthening National Strategic Scientific And Technological Power, Guangzu Bai, Xiaoyang Cao
Thoughts On Systematic Layout Of Strengthening National Strategic Scientific And Technological Power, Guangzu Bai, Xiaoyang Cao
Bulletin of Chinese Academy of Sciences (Chinese Version)
Strengthening the national strategic science and technology (S&T) power is the key path to achieve China's scientific and technological independence, and to accelerate the construction process of a powerful nation of science and technology. In the global history of science and technology development in the past century, along with the shift of the world's scientific center, major developed countries have recognized and strengthened their S&T power from the national strategic level at different stages of development. Based on a profound understanding of the significance of strengthening the systematic layout of national strategic science and technology forces, this paper discusses the …
Efficacy Of As04-Adjuvanted Vaccine Against Human Papillomavirus (Hpv) Types 16 And 18 In Clearing Incident Hpv Infections: Pooled Analysis Of Data From The Costa Rica Vaccine Trial And The Patricia Study, Joseph E. Tota, Frank Struyf, Allan Hildesheim, Paula Gonzalez, Martin Ryser, Rolando Herrero, John Schussler, Naveen Karkada, Ana Cecilia Rodriguez, Nicolas Folschweiller, Carolina Porras, Mark Schiffman, John T. Schiller, Wim Quint, Aimée R. Kreimer, Matti Lehtinen, Cosette M. Wheeler, Joshua N Sampson
Efficacy Of As04-Adjuvanted Vaccine Against Human Papillomavirus (Hpv) Types 16 And 18 In Clearing Incident Hpv Infections: Pooled Analysis Of Data From The Costa Rica Vaccine Trial And The Patricia Study, Joseph E. Tota, Frank Struyf, Allan Hildesheim, Paula Gonzalez, Martin Ryser, Rolando Herrero, John Schussler, Naveen Karkada, Ana Cecilia Rodriguez, Nicolas Folschweiller, Carolina Porras, Mark Schiffman, John T. Schiller, Wim Quint, Aimée R. Kreimer, Matti Lehtinen, Cosette M. Wheeler, Joshua N Sampson
Pathology Research and Scholarship
Clinical trial data and real-world evidence suggest that the AS04-adjuvanted vaccine targeting human papillomavirus types 16 and 18 (AS04-HPV-16/18) vaccine provides nearly 90% protection against cervical intraepithelial neoplasia grade 3 or higher irrespective of type, among women vaccinated before sexual debut. This high efficacy is not fully explained by cross-protection. Although AS04-HPV-16/18 vaccination does not affect clearance of prevalent infections, it may accelerate clearance of newly acquired infections. We pooled data from 2 large-scale randomized controlled trials to evaluate efficacy of the AS04-HPV-16/18 vaccine against clearance of nontargeted incident infections. Results of our analysis do not suggest an effect in …
Memory Care Approaches To Better Leverage Capacity Of Dementia Specialists: A Narrative Synthesis, Jenny Lam, Soeren Mattke
Memory Care Approaches To Better Leverage Capacity Of Dementia Specialists: A Narrative Synthesis, Jenny Lam, Soeren Mattke
Project ECHO Bibliography
Prior research suggests that a scarcity of dementia specialists could hamper access to disease-modifying Alzheimer’s treatments. We describe alternative approaches on how to leverage specialist time for memory care in this narrative synthesis based on 17 semi-structured interviews and a targeted literature review on memory care approaches that leverage specialist time. We identified four types of approaches: community primary care practices empowered with better tools and training; primary care memory clinics; specialty memory clinics and; specialty memory centers. Several approaches to use specialist time efficiently have been implemented and some but not all evaluated. The optimal approach may depend on …
Evaluating Kin And Group Selection As Tools For Quantitative Analysis Of Microbial Data, Jeff Smith, Fredrik Inglis
Evaluating Kin And Group Selection As Tools For Quantitative Analysis Of Microbial Data, Jeff Smith, Fredrik Inglis
Biology Department Faculty Works
Kin selection and multilevel selection theory are often used to interpret experiments about the evolution of cooperation and social behaviour among microbes. But while these experiments provide rich, detailed fitness data, theory is mostly used as a conceptual heuristic. Here, we evaluate how kin and multilevel selection theory perform as quantitative analysis tools. We reanalyse published microbial datasets and show that the canonical fitness models of both theories are almost always poor fits because they use statistical regressions misspecified for the strong selection and non-additive effects we show are widespread in microbial systems. We identify analytical practices in empirical research …
2021-05-19_Michiganoverview_Covidtestingtimes, Michigan Department Of Health & Human Services
2021-05-19_Michiganoverview_Covidtestingtimes, Michigan Department Of Health & Human Services
Michigan COVID-19 Testing Turnaround Data
The COVID Testing Turnaround Time page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-545615--,00.html.
This report was created by the Michigan Department of Health & Human Services, providing data for the past 14 days on the average time it takes for a diagnostic COVID-19 laboratory test to be reported to the state health department. Testing turnaround time data will be updated weekly on Friday mornings.
MDHHS receives results from commercial labs, hospitals, and public health labs. However, public health laboratories perform limited diagnostic testing and disease surveillance for infectious diseases. Total turnaround time is calculated from the difference of …
Vaccination Evasion: Legislating A Solution Through A Revised Vaccinate All Children Act Of 2019, Sophia C. Aguilar
Vaccination Evasion: Legislating A Solution Through A Revised Vaccinate All Children Act Of 2019, Sophia C. Aguilar
Journal of Legislation
No abstract provided.
Covid-19 Newsletter (Vol. 72), Center For Disaster Medicine, New York Medical College
Covid-19 Newsletter (Vol. 72), Center For Disaster Medicine, New York Medical College
COVID-19 Newsletter
No abstract provided.
Phenotypic And Genomic Profiling Of Staphylococcus Argenteus In Canada And The United States And Recommendations For Clinical Result Reporting, Alireza Eshaghi, Carl Bommersbach, Sandra Zittermann, C A Burnham, Robin Patel, Audrey N Schuetz, Samir N Patel, Julianne V Kus
Phenotypic And Genomic Profiling Of Staphylococcus Argenteus In Canada And The United States And Recommendations For Clinical Result Reporting, Alireza Eshaghi, Carl Bommersbach, Sandra Zittermann, C A Burnham, Robin Patel, Audrey N Schuetz, Samir N Patel, Julianne V Kus
Open Access Publications
No abstract provided.
Coxiella Burnetii And Related Tick Endosymbionts Evolved From Pathogenic Ancestors, Amanda E. Brenner, Sebastián Muñoz-Leal, Madhur Sachan, Marcelo B. Labruna, Rahul Raghavan
Coxiella Burnetii And Related Tick Endosymbionts Evolved From Pathogenic Ancestors, Amanda E. Brenner, Sebastián Muñoz-Leal, Madhur Sachan, Marcelo B. Labruna, Rahul Raghavan
Biology Faculty Publications and Presentations
Both symbiotic and pathogenic bacteria in the family Coxiellaceae cause morbidity and mortality in humans and animals. For instance, Coxiella-like endosymbionts (CLEs) improve the reproductive success of ticks—a major disease vector, while Coxiella burnetii causes human Q fever, and uncharacterized coxiellae infect both animals and humans. To better understand the evolution of pathogenesis and symbiosis in this group of intracellular bacteria, we sequenced the genome of a CLE present in the soft tick Ornithodoros amblus (CLEOA) and compared it to the genomes of other bacteria in the order Legionellales. Our analyses confirmed that CLEOA is more closely related to …
Infectious Disease Transmission By Arline Travel, Daniele Provenzano, Sofy Barocio
Infectious Disease Transmission By Arline Travel, Daniele Provenzano, Sofy Barocio
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)
Improvements in aviation technology have led to considerable growth of domestic and international flights worldwide especially during the past four decades. Commercial flights have increased the movement of and have connected people from virtually all corners of the globe since the end of World War II to exceed 3 billion passengers a year since 2013: a sizable proportion of the global human population. Flight times have decreased considerably from the onset of commercial aviation and the range of airliners has extended substantially. A passenger harboring an infectious agent embarking a flight on one continent can be deplaning on another continent …
Coronavirus Disease 2019 Regulatory Response In United States-Assisted Living Communities: Lessons Learned, Sarah Dys, Jaclyn Winfree, Paula Carder, Sheryl Zimmerman, Kali S. Thomas
Coronavirus Disease 2019 Regulatory Response In United States-Assisted Living Communities: Lessons Learned, Sarah Dys, Jaclyn Winfree, Paula Carder, Sheryl Zimmerman, Kali S. Thomas
Institute on Aging Publications
Coronavirus disease 2019 (COVID-19) has disproportionately affected residents, their families, staff, and operators of congregate care settings. Assisted living (AL) is a type of long-term care setting for older adults who need supportive care but not ongoing nursing care and emphasizes a social model of care provision. Because AL is a type of long-term care, it has at times been referenced along with nursing homes in discussions related to COVID-19 but not recognized for its different care practices that pose unique challenges related to COVID-19; in that manner, it has largely been left out of the COVID-19 discourse, although ~812,000 …
Bibliometric Survey On Effect Of Socio-Economic Factors On Spread Of Corona Virus (Covid-19), Seema Patil Prof., Aayushi Verma Ms, Isha Patil Ms, Ravneesh Singh Mr, Raghav Gaur Mr
Bibliometric Survey On Effect Of Socio-Economic Factors On Spread Of Corona Virus (Covid-19), Seema Patil Prof., Aayushi Verma Ms, Isha Patil Ms, Ravneesh Singh Mr, Raghav Gaur Mr
Library Philosophy and Practice (e-journal)
The Novel Coronavirus disease has been rapidly spreading all around the globe, from the time when it was first reported in the Wuhan city of China. The primary focus of this bibliometric survey is to distinguish the documents which have hypothesized and expanded on the effects of various socio-economic factors when it comes to the spread of the Coronavirus.
This survey does the evaluation on the 480 documents found. The United Kingdom of the Great Britain and United States have contributed the largest number of publications in this field of research followed closely by India and Italy.
The survey includes …
2021-05-18_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services
2021-05-18_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services
Michigan COVID-19 Syndromic Surveillance System Data
The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.
Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …
The Effect Of Generic Market Entry On Antibiotic Prescriptions In The United States, Cecilia Kållberg, Jemma Hudson, Hege Salvesen Blix, Christine Årdal, Eili Klein, Morten Lindbæk, Kevin Outterson, John-Arne Røttingen, Ramanan Laxminarayan
The Effect Of Generic Market Entry On Antibiotic Prescriptions In The United States, Cecilia Kållberg, Jemma Hudson, Hege Salvesen Blix, Christine Årdal, Eili Klein, Morten Lindbæk, Kevin Outterson, John-Arne Røttingen, Ramanan Laxminarayan
Faculty Scholarship
When patented, brand-name antibiotics lose market exclusivity, generics typically enter the market at lower prices, which may increase consumption of the drug. To examine the effect of generic market entry on antibiotic consumption in the United States, we conducted an interrupted time series analysis of the change in the number of prescriptions per month for antibiotics for which at least one generic entered the US market between 2000 and 2012. Data were acquired from the IQVIA Xponent database. Thirteen antibiotics were analyzed. Here, we show that one year after generic entry, the number of prescriptions increased for five antibiotics (5 …