Digital Commons Network^™

Experience With Liposomal Amphotericin B In Outpatient Parenteral Antimicrobial Therapy, Yvonne J Burnett, Andrej Spec, Mohamed M Ahmed, William G Powderly, Yasir Hamad

Open Access Publications

Outpatient parenteral antimicrobial therapy (OPAT) is a safe, effective, and convenient treatment strategy for patients receiving intravenous antimicrobials in the outpatient setting; however, data are limited describing the use and safety of liposomal amphotericin B (L-AMB). Records of patients receiving L-AMB OPAT between 1/1/2015 and 7/31/2018 were retrospectively reviewed. The primary objective was to describe the OPAT patient population discharged on L-AMB and evaluate factors associated with readmission and adverse events (AEs). Analysis was performed to evaluate for predictors of worse outcomes. Forty-two patients (67% male, median age 50 years) were identified, most of whom were treated for histoplasmosis. The …

A Bibliometric Analysis Of Research Trends Of Inter Linkages Between Disaster Management And Law, Shashikala Gurpur Dr, Manika Kamthan Dr, Vartika Tiwari Ms.

Library Philosophy and Practice (e-journal)

This study is the bibliometric analysis of research publications that focus on highlighting the inter linkages between disaster management and laws. The main objectives of the study are to determine the frequency of such publications and also to establish that inter linkages between disaster management and law have not received enough attention from the researchers. The data was collected from the Scopus database using VOSviewer software. Literatures written from 2000 to 2020 were perused. The study consisted of a total of 1649 documents which are classified into articles, letters, editorials conference papers, and reviews. Data collected is analyzed and presented …

Spatiotemporal Patterns Of Human Mobility And Its Association With Land Use Types During Covid-19 In New York City, Yuqin Jiang, Xiao Huang, Zhenlong Li

Faculty Publications

The novel coronavirus disease (COVID-19) pandemic has impacted every facet of society. One of the non-pharmacological measures to contain the COVID-19 infection is social distancing. Federal, state, and local governments have placed multiple executive orders for human mobility reduction to slow down the spread of COVID-19. This paper uses geotagged tweets data to reveal the spatiotemporal human mobility patterns during this COVID-19 pandemic in New York City. With New York City open data, human mobility pattern changes were detected by different categories of land use, including residential, parks, transportation facilities, and workplaces. This study further compares human mobility patterns by …

Security Concerns Vs. Monied Interests?: The Role Of Agenda Setting In Homeland Security, Andrew Christopher Ziegler

Hatfield Graduate Journal of Public Affairs

This paper applies public policy concepts such as agenda setting, resource allocation, lobbying, and campaign rhetoric to the field of homeland security. The analysis examines the allocation of resources among the U.S. federal government’s five broad homeland security priorities during the fiscal years of 2012-2017. An overemphasis on border security has led to a disproportionate allocation of resources among these various priorities. The uneven distribution is the summation of electoral ambitions, campaign contributions, and corporate lobbying. This analysis highlights the negative consequences that are a direct result of an unbalanced allotment, cumulating in a slow and uncoordinated federal response to …

A Multicenter Evaluation Of Viral Bloodstream Detections In Children Presenting To The Emergency Department With Suspected Systemic Infection., Christina A. Rostad, Neena Kanwar, Jumi Yi, Claudia R. Morris, Jennifer Dien Bard, Amy Leber, James Dunn, Kimberle C. Chapin, Anne J. Blaschke, Judy A. Daly, Leslie Hueschen, Matthew Jones, Elizabeth Ott, Jeffrey Bastar, Kevin M. Bourzac, Rangaraj Selvarangan

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Fever is a common symptom in children presenting to the Emergency Department (ED). We aimed to describe the epidemiology of systemic viral infections and their predictive values for excluding serious bacterial infections (SBIs), including bacteremia, meningitis and urinary tract infections (UTIs) in children presenting to the ED with suspected systemic infections.

METHODS: We enrolled children who presented to the ED with suspected systemic infections who had blood cultures obtained at seven healthcare facilities. Whole blood specimens were analyzed by an experimental multiplexed PCR test for 7 viruses. Demographic and laboratory results were abstracted.

RESULTS: Of the 1114 subjects enrolled, …

A Bibliometric Analysis Of Research Trends Of Inter Linkages Between Disaster Management And Law, Shashikala Gurpur Dr., Manika Kamthan Dr., Vartika Tiwari Ms.

Library Philosophy and Practice (e-journal)

This study is the bibliometric analysis of research publications that focus on highlighting the inter linkages between disaster management and laws. The main objectives of the study are to determine the frequency of such publications and also to establish that inter linkages between disaster management and law have not received enough attention from the researchers. The data was collected from the Scopus database using VOSviewer software. Literatures written from 2000 to 2020 were perused. The study consisted of a total of 1649 documents which are classified into articles, letters, editorials conference papers, and reviews. Data collected is analyzed and presented …

Landscape Genetics Of American Beaver In Coastal Oregon, Clinton W. Epps, Vanessa M. Petro, Tyler G. Creech, Rachel S. Crowhurst, Matthew J. Weldy, Jimmy D. Taylor

United States Department of Agriculture Wildlife Services: Staff Publications

American beaver (Castor canadensis) have been translocated for population restoration, reduction of human‐wildlife conflict, and enhancement of ecosystem function. Yet few studies have assessed dispersal of beaver, making it difficult to determine at what scale translocations are appropriate. Genetic studies can provide inferences about gene flow, and thus dispersal. We used a landscape genetic approach to evaluate whether landscape features influenced gene flow among beaver in the Coast Range of western Oregon, USA, using samples collected April–September 2014. We collected genetic samples from live‐captured (n=232), road‐killed (n=2) and trapper‐provided (n=58) tissue samples and genotyped them at 10 microsatellite loci. We …

Evaluation Of Food Safety Practices At Louisiana Summer Feeding Sites And Food Safety Communication Via Social Media During Crises, Peyton E. Haynes

LSU Master's Theses

The United States Department of Agriculture’s Summer Food Service Program (SFSP) provided children under the age of 18 in low-income areas 145 million free meals in 2018 through summer feeding sites. Food safety issues arise for Louisiana feeding sites due to time-temperature controlled foods served, weather patterns in Louisiana, seasonal staff and short operation time, and lack of equipment. The purpose of this study was to assess food safety practices at Louisiana feeding sites through observational study with intention to compare food practices at institutional and noninstitutional sites. A rubric following USDA food safety guidelines based on categories: hot holding, …

Research Trends In Amish Population Health, A Growing Literature About A Growing Rural Population, Cory Anderson, Lindsey Potts

Journal of Rural Social Sciences

The Amish are an endogamous rural population experiencing rapid growth; consequently, they have attracted the attention of population health researchers and service providers. With approximately one quarter of all Amish studies publications now devoted to population health (n=246), the time is ripe to review research trends. Using bibliometric measures, we map the genealogy, influence, and configuration of Amish health publications. Amish population health research has (1) a health culture-focused core with clusters representing social science and health practice, (2) peripheral clusters addressing health conditions–mental, physical, and injury/safety–and (3) several clusters straddling both. We identify fruitful interdisciplinary studies and recommend researchers …

2021-05-17_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Identifying The Cell Composition And Clonal Diversity Of Supratentorial Ependymoma Using Single Cell Rna-Sequencing, James He

University Scholar Projects

Ependymoma is a primary solid tumor of the central nervous system. Supratentorial ependymoma (ST-EPN), a subtype of ependymomas, is driven by an oncogenic fusion between the ZFTA and RELA genes in 70% of cases. We introduced this fusion into neural progenitor cells of mice embryos via in utero electroporation of a non-viral binary piggyBac transposon system containing ZFTA-RELA. From preliminary data in the LoTurco lab, inducing the expression of ZFTA-RELA into different neural progenitor cells produces tumors of varying lethality and cellular composition. To define the cellular composition and subclonal diversity of ST-EPN tumors, we used single cell RNA-sequencing to …

Macrophage Mediated Recognition And Clearance Of Borrelia Burgdorferi Elicits Myd88-Dependent And -Independent Phagosomal Signals That Contribute To Phagocytosis And Inflammation., Sarah J Benjamin, Kelly L Hawley, Paola Vera-Licona, Carson J La Vake, Jorge L Cervantes, Yijun Ruan, Justin D Radolf, Juan C Salazar

Faculty Research 2021

BACKGROUND: Macrophages play prominent roles in bacteria recognition and clearance, including Borrelia burgdorferi (Bb), the Lyme disease spirochete. To elucidate mechanisms by which MyD88/TLR signaling enhances clearance of Bb by macrophages, we studied wildtype (WT) and MyD88

RESULTS: MyD88

CONCLUSION: Our findings show that MyD88 signaling enhances, but is not required, for bacterial uptake or phagosomal maturation and provide mechanistic insights into how MyD88-mediated phagosomal signaling enhances Bb uptake and clearance.

Introduction To The Special Issue: Relationships In The Time Of Covid-19, Jennifer L. Bevan, Pamela J. Lannutti

Communication Faculty Articles and Research

This introduction describes the background for the special issue entitled “Relationships in the Time of COVID-19: Examining the Effects of the Global Pandemic on Personal Relationships.” It also examines reasons for conducting interdisciplinary research on COVID-19 and personal relationships, and previews first articles published in the special issue.

Brief Overview Of Approaches And Challenges In New Antibiotic Development: A Focus On Drug Repurposing, Natalie K. Boyd, Chengwen Teng Pharm.D., Ph.D., Christopher R. Frei

Faculty Publications

Drug repurposing, or identifying new uses for existing drugs, has emerged as an alternative to traditional drug discovery processes involving de novo synthesis. Drugs that are currently approved or under development for non-antibiotic indications may possess antibiotic properties, and therefore may have repurposing potential, either alone or in combination with an antibiotic. They might also serve as “antibiotic adjuvants” to enhance the activity of certain antibiotics.

Trend Of Research Visualization Of Covid-19 Complications In Pubmed Database Using Scientometric Analysis From 2020 To March 20, 2021, Dr. Abeel Naseer, Dr. Muhammad Shoaib, Mr. Nusrat Ali, Dr. Muhammad Bilal

Library Philosophy and Practice (e-journal)

This study focused to evaluate the published articles on PubMed whose focus was to study the different relations between COVID 19, and different complications caused due to it. The main complications that were used to formulate this study are Deep Venous Thrombosis (DVT), Stroke, Pulmonary Embolism, Disseminated Intravascular Coagulation (DIC), Myocardial Infarction (MI), anosmia, and pneumonia. The data was extracted from the PubMed database on March 20, 2021at 03:20 PM, PST with the period of 2020 to March 20, 2021. We used Biblioshiny, VOSviewer, and MS Excel software to analyze data and found 2375 published documents. The results revealed that …

2021-05-16_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Health Impacts Of Wildfire Smoke As A Consequence Of Climate Change And Recommendations For Public Health Officials And The General Public In The Albuquerque Metropolitan Area, Jegason Diviant

Climate Change and Public Health Preparedness

No abstract provided.

Development Of Physical Qualities Of Preschool Children, Laziz Kholmurodov

Mental Enlightenment Scientific-Methodological Journal

This article introduces a special set of exercises for the effective organization of the process of physical education for preschool children, the development of their physical qualities in relation to their age, as well as the development of levels of physical fitness. The purpose of our research is to carry out a study into the development of physical qualities of children aged 5-7, as well as the analysis of indicators of physical development of preschool children. As the correct physical education of preschoolers is one of the most significant importance, this article intends to assist with providing general and specific …

2021-05-15_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Point Of Care Infectious Disease Diagnosis Via Isothermal Nucleic Acid Amplification Integrated Into A Sample To Answer Device, Abrar Al Maghribi

KGI Theses and Dissertations

Sexually transmitted infections caused by Chlamydia trachomatous (CT) and Neisseria gonorrhea (NG) are often under-diagnosed, miss-diagnosed, and not properly treated, leading to long term complications such as ectopic pregnancy and infertility, and to emergence of drug resistance. Dengue virus (DENV) infections can cause dengue fever (DF), which if not properly managed can lead to Dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), causing significant morbidity and mortality. In both cases, early and accurate detection at the point of care is critical to facilitate proper patient care and disease management. Nucleic acid amplification tests (NAATs) provide suitable sensitivity and specificity, …

Association Of Hypothermia With Increased Mortality Rate In Sars-Cov-2 Infection, Naaz Fatteh, Glen E. Sutherland, Radleigh Santos, Rita Zeidan, Alexandra P. Gastesi, Christopher D. Naranjo

Mathematics Faculty Articles

Objective

We observed patients to have variable temperatures. The objective of the study was to identify if hypothermia in a patient infected with SARS-CoV-2 is associated with a higher than expected mortality.

Methods

We reviewed 331 charts from patients hospitalized with SARS-CoV-2 between March 9 to April 20, 2020.

Results

The probability of death was 2.06 times higher for those with hypothermia than those without [95% C.I. (1.25, 3.38)]. In ventilated patients, there were 32 deaths. Of those, 75% had been hypothermic. In a prior review of 10,000 non-SARS-CoV-2 patients with sepsis, the mortality rate in patients with hypothermia was …

Design, Synthesis, And Evaluation Of Carbapenem And Cephalosporin Antibiotics To Counter Resistant 21st Century Pathogens, Maha Alqurafi

Chemistry Theses and Dissertations

Antibiotics represent one of mankind’s most important discoveries, enabling longer, more productive lives. Carbapenem antibiotics are one of the most potent classes of β-lactams and often represent the last resort used to treat patients who are seriously stricken by bacterial infections. Carbapenems possess a broad spectrum of antibacterial activity including efficacy against the majority of Gram-positive and Gram–negative bacteria. Unfortunately, the emergence of antibiotic resistant strains is posing a serious threat to existing antibiotics. New discoveries in the antibiotic field are desperately needed to counter the threat of rapidly evolving bacterial resistance. Despite the investment of billions of dollars, and …

Embracing Entrepreneurship, Naomy Sengebwila, Naomy Nyendwa Sengebwila

Doctor of Ministry Projects and Theses

Embracing Entrepreneurship

How Christian Social Innovation and Entrepreneurship can Lead to Sustainable Communities in Zambia and Globally

Embracing Entrepreneurship

A Dissertation Presented to the Faculty of Perkins School of Theology Southern Methodist University in Partial Fulfillment of the Requirements for the degree of Doctor of Ministry by

Name of Student

Naomy Nyendwa Sengebwila

Name of Student: Naomy Nyendwa Sengebwila

Date: 03/31/2021

How Christian Social Innovation and Entrepreneurship Can Lead to Sustainable Communities in Zambia and globally

TABLE OF CONTENTS

ACKNOWLEDGMENTS . . . . . . . . . . . . . . . . . . . . …

Spring 2021

Scientia

From the Dean: A Decade of Purpose and Progress; Lab Notes: Alumna Wins Gordon Bell Special Prize, New Scholarships, Vaccination Site Volunteers; Women in Science Lecture, National Institutes of Health Grants, "Unequal Cities" Research; All Hands on Deck: Inspired pandemic approaches showcase interdisciplinary acumen in action; Unlocking Potential: Christopher Beasley thinks psychology is key to academic transformation for the formerly incarcerated; Puzzle Master: Bridget Tenner goes to pieces solving problems in cutting-edge mathematics

Plasmonically-Enhanced Ultrasensitive Biodetection Technologies, Zheyu Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Detection and quantification of biomolecules within biological fluids and tissues is of fundamental importance to biomedical research and clinical diagnostics. It is impossible to fully characterize complex, non-linear, biochemical systems without being able to accurately and quantitatively determine the component molecules. This problem is ubiquitous across all domains of biomedical research, and it is a major barrier to fully understanding health, ageing, and disease. Such bottlenecks are extremely challenging to be solved, especially for proteins and peptides, which do not have amplification schemes such as polymerase chain reaction for nucleic acids, because relevant concentrations of molecules related to diseases such …

Examining Mental Health In Northern Haiti, Michael Galvin

Arts & Sciences Graduate Student Theses and Dissertations

Mental health is a severely neglected field in low- and middle-income countries globally. Populations in countries such as Haiti demonstrate a high level of need for mental health services despite a lack of services and trained professionals. In addition to the dearth of biomedical services, local belief systems and explanatory models lead a majority of the population to rely on traditional medicine as their first option for care. The goal of this dissertation is to characterize mental health beliefs, practices, and services in northern Haiti by examining the relationship between traditional beliefs and mental illness, assessing the impact of traumatic …

Exploring The Service Utilization Of Formerly Incarcerated Persons With Substance Use Disorders, Sara Beeler-Stinn

Arts & Sciences Graduate Student Theses and Dissertations

We are in a new era of mass reentry from years of mass incarceration (Chamberlain & Wallace, 2016) that will is complicated by challenging conditions at release (Mallik-Kane & Visher, 2008). Recent data suggests that rearrest rates within nine years of release are over 80% among individuals released from prison (Alper et al., 2018). These challenges are further complicated by drug and alcohol abuse with over 20 million individuals aged 12 and older reporting living with a substance use disorder (SAMSHA, 2019). Incarcerated and formerly incarcerated populations are estimated to have rates of substance use disorders (SUDs) often 10 to …

Understanding Immune Responses With Single-Cell Rna Sequencing And Cytof Across Different Diseases And Model Organisms, Ekaterina Esaulova

Arts & Sciences Graduate Student Theses and Dissertations

The immune system is an integral part of a healthy functioning organism. Immune responses during the disease are complex and include the interplay of many cell subsets. Integrated genomics and bioinformatics usage can yield unique insights into the immune system’s function in health and disease at a single-cell resolution. Here we utilize complimentary single-cell profiling technologies, scRNA-seq and CyTOF, to explore immune responses across diseases and model organisms. Our approach included leveraging scRNA-seq on few samples to understand the immune response landscape and select key markers for a follow-up protein level validation using an appropriate number of replicates by FACS …

The Role Of Cd53 In Hematopoietic Development, Stress, And Malignancy, Zev Joshua Greenberg

Arts & Sciences Graduate Student Theses and Dissertations

For a cell to function properly, it must be able to interact with and respond to environmental cues; however, expression of surface molecules, proteins, and receptors is not always sufficient to execute a cellular response. Proper organization of the plasma membrane is necessary to facilitate these highly regulated protein interactions, such that a cell can respond to stressors, growth factors, and other signaling molecules. Tetraspanins are a family of transmembrane proteins which help correctly orient surface molecules on the cell membrane, often through tetraspanin enriched microdomains, a membrane structure similar to lipid rafts. As a family, tetraspanins are known to …

Analyzing Empirical Quality Metrics Of Deep Learning Models For Antimicrobial Resistance, Huy H. Nguyen, Sanjay Pillay, Allison Roderick, Hao Wang, John Santerre

SMU Data Science Review

Antimicrobial Resistance (AMR) is a growing concern in the medical field. Over-prescription of antibiotics as well as bacterial mutations have caused some once lifesaving drugs to become ineffective against bacteria. However, the problem of AMR might be addressed using Machine Learning (ML) thanks to increased availability of genomic data and large computing resources. The Pathosystems Resource Integration Center (PATRIC) has genomic data of various bacterial genera with sample isolates that are either resistant or susceptible to certain antibiotics. Past research has used this database to use ML algorithms to model AMR with successful results, including accuracies over 80%. To better …