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Transfer Transcriptomic Signatures For Infectious Diseases, Julia Di Iulio, Istvan Bartha, Roberto Spreafico, Herbert W Virgin, Amalio Telenti

2020-Current year OA Pubs

The modulation of the transcriptome is among the earliest responses to infection. However, defining the transcriptomic signatures of disease is challenging because logistic, technical, and cost factors limit the size and representativeness of samples in clinical studies. These limitations lead to a poor performance of signatures when applied to new datasets. Although the study focuses on infection, the central hypothesis of the work is the generalization of sets of signatures across diseases. We use a machine learning approach to identify common elements in datasets and then test empirically whether they are informative about a second dataset from a disease or …

Evaluation Of Serum-Derived Bovine Immunoglobulin Protein Isolate In Subjects With Decompensated Cirrhosis With Ascites, Matthew J. Stotts, Amanda Cheung, Muhammad B. Hammami, David J. Westrich Jr., Eric Anderson, Lauren Counts, Alex S. Befeler, Adrian M. Di Bisceglie, Charlene Prather

2020-Current year OA Pubs

Background Bacterial translocation plays a pivotal role in the natural course of cirrhosis and its complications. Serum-derived bovine immunoglobulin (SBI) is an oral medical food that has been shown to both reduce inflammation in the intestines and neutralize bacteria. It represents a unique intervention that has not been studied in this population. Methodology We conducted a prospective open-label trial with an eight-week treatment phase of SBI. Individuals were assessed using lactulose breath testing, serum markers for enterocyte damage and bacterial translocation, and the Chronic Liver Disease Questionnaire (CLDQ) prior to and after completion of the treatment phase. Results We evaluated …

Trade Marking ‘Covid’ And ‘Coronavirus’ In The Usa: An Empirical Review, Irene Calboli

Faculty Scholarship

Famous and sensational events often lead to several entities filing trade mark applications that include terms related to these events. The most recent example of this phenomenon is the COVID-19 pandemic, which has led to large numbers of (largely controversial) filings worldwide.

In this article, I review the applications including the terms ‘COVID’ and ‘Coronavirus’ filed with the United States Patent and Trademark Office (USPTO) in 2020 based on the data available and recorded by the end of January 2021. These data offer significant information related to the type of products for which the applications were filed, the type of …

Alfaxalone Successfully Immobilizes Small Indian Mongooses (Urva Auropunctata): A Field Report, Caroline C. Sauvé, Yves Rondenay, Are R. Berentsen, Mel J. Rivera-Rodriguez, Patrick A. Leighton

United States Department of Agriculture Wildlife Services: Staff Publications

We investigated intramuscular administration of alfaxalone (5.3–10.0 mg/kg) as an immobilizing agent in free-ranging small Indian mongooses (Urva auropunctata) on the island of St. Kitts, West Indies. From 5–11 January 2020, we successfully immobilized 10 of 11 mongooses. Alfaxalone provided rapid onset (median = 3 min) of immobilization. Mean duration of immobilization was 16.8 ± 3 min. Mean recovery time was 5.6 ± 1 min. There was no effect of dose administered on induction, anesthesia, or recovery times at the dose range used. We concluded that alfaxalone represents an effective alternative to dissociative agents for the immobilization of free-ranging mongooses. …

Comparing Management Programs To Reduce Red–Tailed Hawk Collisions With Aircraft, Brian Washburn, Craig K. Pullins, Travis L. Guerrant, Gregory J. Martinelli, Scott F. Beckerman

United States Department of Agriculture Wildlife Services: Staff Publications

Wildlife-aircraft collisions (wildlife strikes) pose a serious safety risk to aircraft. Raptors (i.e., hawks and owls) are one of the most frequently struck guilds of birds within North America. Although raptors (most notably red-tailed hawks [Buteo jamaicensis]) are commonly managed at most airports and military bases, there is no scientific information available regarding comparisons of the efficacy of raptor management programs for reducing raptor-aircraft collisions. Therefore, we conducted a study to examine the efficacy of 2 raptor hazard management programs implemented at Chicago's O'Hare International Airport (ORD). The first raptor management program (Phase I) occurred during January 2010–June 2013 and …

Strategic Testing Approaches For Targeted Disease Monitoring Can Be Used To Inform Pandemic Decision-Making, James D. Nichols, Tiffany L. Bogich, Emily Howerton, Ottar N. Bjørnstad, Rebecca K. Borchering, Matthew Ferrari, Murali Haran, Christopher Jewell, Kim M. Pepin, William J.M. Probert, Juliet R.C. Pulliam, Michael C. Runge, Michael Tildesley, Cecile Viboud, Katriona Shea

United States Department of Agriculture Wildlife Services: Staff Publications

More than 1.6 million Servere Acute Respiratory Syndrome Cronovirus 2(SARS-COV-2)tests were administered daily in the United States at the peak of the epidemic, with a significant focus on individual treatment. Here, we show that objective-driven, strategic sampling designs and analyses can maximize information gain at the population level, which is necessary to increase situational awareness and predict, prepare for, and respond to a pandemic, while also continuing to inform individual treatment. By focusing on specific objectives such as individual treatment or disease prediction and control (e.g., via the collection of population- level statistics to inform lockdown measures or vaccine rollout) …

Public Health Campaigns And The Covid-19 Vaccine: An Analysis Of The Role Marketing And Public Relations Play In Combating Vaccine Hesitancy And The Spread Of Misinformation On Social Media, Emily Mahoney

Journalism

This study is intended to determine the role social media has as a messaging platform for information regarding the COVID-19 vaccine and the persuasiveness misinformation on these platforms has on people’s perceptions. Researching how the impact of COVID-19 vaccine misinformation and falsehoods can affect perceptions of our society will show how important marketing, PR, and other professional communicators roles are during a time like this.

Methods For Extending Biomedical Reference Ontologies And Interface Terminologies For Ehrr Text Annotation, Vipina Kuttichi Keloth

Dissertations

Biomedical ontologies and terminologies are a cornerstone in various electronic health record systems (EHRs) for encoding information related to diseases, diagnoses, treatments, etc. Ontologies in general represent entities (concepts) and events along with all interdependent properties and relationships in an efficient way to facilitate easy access, retrieval and sharing. With the landscape of medicine rapidly changing, biomedical ontologies and terminologies need to rapidly evolve to support interoperability, medical coding, record keeping, and healthcare activities in general, and to facilitate interdisciplinary research. Extending ontologies by identifying new and missing concepts plays a vital role in the maintenance of ontologies to keep …

2021-05-31_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Patient-Reported Outcomes Through 1 Year Of An Hiv-1 Clinical Trial Evaluating Long-Acting Cabotegravir And Rilpivirine Administered Every 4 Or 8 Weeks (Atlas-2m), Vasiliki Chounta, Edgar T. Overton, Anthony Mills, Susan Swindells, Paul D. Benn, Simon Vanveggel, Rodica Van Solingen-Ristea, Yuanyuan Wang, Krischan J. Hudson, Mark S. Shaefer, David A. Margolis, Kimberly Y. Smith, William R. Spreen

Journal Articles: Infectious Diseases

BACKGROUND: Advances in HIV-1 therapeutics have led to the development of a range of daily oral treatment regimens, which share similar high efficacy rates. Consequently, more emphasis is being placed upon the individual's experience of treatment and impact on quality of life. The first long-acting injectable antiretroviral therapy for HIV-1 (long-acting cabotegravir + rilpivirine [CAB + RPV LA]) may address challenges associated with oral treatment for HIV-1, such as stigma, pill burden/fatigue, drug-food interactions, and adherence. Patient-reported outcomes (PROs) collected in an HIV-1 clinical trial (ATLAS-2M; NCT03299049) comparing participants' experience with two dosing regimens (every 4 weeks [Q4W] vs. every …

The Effects Of Infliximab On The Fibrosis Response Of Three-Spine Stickleback, Mita Kale

Honors Scholar Theses

This study was conducted to determine if the monoclonal antibody drug infliximab could effectively suppress the fibrosis immune response in three-spine stickleback fish. Successful suppression of this response could allow for further study of cestode infection and growth without the presence of fibrosis. Infliximab’s efficacy was investigated through conducting two intraperitoneal injection experiments and examinations of the fibrosis in the body cavity of the euthanized stickleback. We used immune adjuvant alum to induce a fibrosis response without the presence of the S. solidus tapeworm parasite. Ultimately, the differences in fibrosis levels between the treatment groups that received alum and the …

The Determinants Of Stunting For Children Aged 24-59 Months In Kulon Progo District 2019, Chatrine Aprilia Hendraswari, Yuliasti Eka Purnamaningrum, Tri Maryani, Yani Widyastuti, Sakinah Harith

Kesmas

This study pertains to stunting in children in Indonesian with z-scores of less than -2 Standard Deviation (SD) and less than -3 SD. The preliminary study results showed the highest prevalence of stunting to be 22.6%, at the Temon II Primary Health Care in Kulon Progo District. The study aimed to assess the determinants of stunting children aged 24–59 months. This study was conducted from September 2018–May 2019. The design of this study was analytical observational with study design case-control. The sample was 60 children aged 24–59 months. The method utilized proportional sampling, whereas the data analysis applied chi-square and …

Empowering Health Cadres To Support Drug-Resistant Tuberculosis (Dr-Tb) Patient To Enroll In Treatment, Esty Febriani, Adik Wibowo, Neeraj Kak, Hala Jassim Al Mossawi

Kesmas

Tuberculosis (TB) remains a big challenge globally, while the involvement of health cadres’ constitutes one of the key strategies for the TB program in Indonesia. These roles were further expanded to providing support to DR-TB patients. This study was a qualitative study, conducted in 2015 to explore the various factors which influence the performance of health cadres’ in supporting DR-TB patients to enroll in treatment. A total of 39 informants consisting of 24 health cadres, three nurses, four DR-TB patients, and three family members, two peer support, a head of primary health care, and two TB staffs from the District …

Attitudes Concerning Sexual Behavior Towards Risky Sexual Behavior Of Sexual Transmitted Infections Among Male Adolescents In Indonesia, Helda Helda, Nurul Muchlisa

Kesmas

There has been an increase of sexually transmitted infections (STIs) such as HIV/AIDS worldwide, especially in Indonesia. Several studies on adolescent behavior, especially the male as the main predictor, reported increased in STIs’ cases due to risky sexual behavior. This study aimed to show the relationship between attitudes, sexual behavior, and the risks of STIs among male adolescents in Indonesia based on the Indonesia Demographic and Health Survey (IDHS) data in 2017. This cross-sectional study involved 10,547 male adolescents using the total sampling method according to the inclusion and exclusion criteria. Data were analyzed using a complex sample logistic regression …

Larvicidal Potency Of Dioscorea Sansibarensis Leaf Extract Against Vector Mosquitoes: Anopheles Gambiae S.S. And Culex Quinquefasciatus, Anitha Philbert

Tanzania Journal of Science

Mosquitoes are responsible for transmission of illnesses of public health importance including malaria, lymphatic filariasis, dengue, chikungunya, and many other diseases caused by viruses. Vector control using synthetic insecticides has been the cornerstone for management of vector-borne diseases. However, the chemical based interventions have not been sustainable due to emergency of resistance against insecticides among disease vectors. Plant based mosquitocidal products can be potential alternative tools in vector control. Therefore, the present study aimed at exploring the larvicidal properties of Dioscorea sansibarensis leaf extract against malaria and lymphatic filariasis vectors; Anopheles gambiae s.s. and Culex quinquefasciatus. The larvicidal activities of …

Application Of Optimal Control To Tuberculosis Model With Parameter Estimations: Bayesian Approach, Goodluck M Mlay, Alfred K Hugo

Tanzania Journal of Science

In this paper, one-strain tuberculosis (TB) model with two control mechanisms, education campaigns and chemoprophylaxis of TB-infected patients, was studied to determine their effects on the reduction of latent and active TB cases. In the case of analysis, boundedness and positivity of the model solutions were carried out to determine the biological feasibility of the study. Besides, the calibration of the parameters by utilizing the identifiability technique through the Markov chain Monte Carlo (MCMC) was thoroughly analysed. The optimum conditions for controlling TB were derived from the Pontryagin Maximum Principle. The numerical simulations were carried out using the forward-back sweep …

Psychological Impact Of Novel Coronavirus Covid-19 Across The Globe-A Review, Sadaf Shaheen, Iram Asim, Rida Zainab, Humaira Yasmeen

Journal of Bioresource Management

The recent outbreaks of novel coronavirus disease have unprecedent impact on mental health of patients, front-line healthcare workers and local population. However, the impact is not fully documented. This review explores stress-driven factors, stress-vulnerable groups and stress management interventions. Repetitive exposure to mass media and inappropriate health protective measures has heightened stress responses. Fear of not getting recovered from COVID-19 and disaffection has profound impact of infected individuals and their families. They may experience fear, anxiety, anger, sleep deprives and anorexia which may weakens their immune system thus making them vulnerable to COVID-19. The COVID-19 pandemic has underscored potential gaps …

Stock Markets Performance During A Pandemic: How Contagious Is Covid-19?, Yara Abushahba

Theses and Dissertations

Background and Motivation: The coronavirus (“COVID-19”) pandemic, the subsequent policies and lockdowns have unarguably led to an unprecedented fluid circumstance worldwide. The panic and fluctuations in the stock markets were unparalleled. It is inarguable that real-time availability of news and social media platforms like Twitter played a vital role in driving the investors’ sentiment during such global shock.

Purpose:The purpose of this thesis is to study how the investor sentiment in relation to COVID-19 pandemic influenced stock markets globally and how stock markets globally are integrated and contagious. We analyze COVID-19 sentiment through the Twitter posts and investigate its …

The Role Of Irak-1 Transcripts In Sepsis, Adithya Subramanian Sahasranamam

Theses

Sepsis is a complex, life-threatening syndrome that can lead to systemic organ failure and dysfunction. Its high morbidity and mortality rates makes it a critical global health issue. The primary factors at play during sepsis are abnormal inflammation and a lack of oxygen supply to the tissues and muscles. The toll-like receptors play a crucial role in eliciting innate immune in response to infection, primarily through the interleukin-1 receptor-associated kinase (IRAK) pathways. Disturbances in the homeostasis of IRAK signaling cascades can lead to immune dysfunction. n this paper, we review the molecular mechanisms of IRAK-1, an important mediator of TLR-induced …

Brown Treesnake Mortality After Aerial Application Of Toxic Baits, Scott M. Goetz, Eric T. Hileman, Melia G. Nafus, Amy A. Yackel Adams, Amanda R. Bryant, Robert N. Reed, Shane R. Siers

United States Department of Agriculture Wildlife Services: Staff Publications

Quantitative evaluation of control tools for managing invasive species is necessary to assess overall effectiveness and individual variation in treatment susceptibility. Invasive brown treesnakes (Boiga irregularis) on Guam have caused severe ecological and economic effects, pose a risk of accidental introduction to other islands, and are the greatest impediment to the reestablishment of extirpated native fauna. An aerial delivery system for rodent‐based toxic baits can reduce brown treesnake abundance and heterogeneity among individuals may influence bait attraction or toxicant susceptibility. Previous baiting trials have either been simulated aerial treatments or relied on slightly different bait capsule compositions and the results …

Mitigation Of Airborne Contaminant Spread Through Simple Interventions In An Occupied Single-Family Home, Florida Solar Energy Center, Nazim Muradov

FSEC Energy Research Center®

Historically, reducing aerosol-based transmission of respired viruses in indoor environments has been of importance for controlling influenza viruses and common-cold rhinoviruses. The present public health emergency associated with SARS-CoV-2 makes this topic critically important. Yet to be tested is the potential effectiveness of simple interventions that create an isolation zone (IZ) for a suspected/confirmed sick or sensitive person requiring quarantine. The intent in existing homes is to find a practical means to mitigate exposure to airborne contaminants. In creating an IZ in an occupied single-family home in the study, four simple strategies were tested. The test configurations were: (1) IZ …

Urban Water Future: What Can We Learn From The Singapore Experience?, Bambang Susantono, Sarah Hui Li

CSID Journal of Infrastructure Development

Asia and the Pacific region is a hot spot for water insecurity in the world. With water resources such as ground and surface water depleting, the demand for water consumption increases as urban population continues to grow. Meanwhile, non-revenue water (NRW) leads to inefficient water service delivery, waste of energy, drinking water contamination, loss of revenue, and increased operation costs. As the water stress continues in the region, what can cities in the region do to sustain their water future? To answer this question, this paper uses Singapore as an example and draws lessons from its urban water management experience. …

2021-05-30_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Swot Analysis Of Psbb Policy Implementation At Public Facilities Or Areas In Bekasi City In March-June 2020, Lidya Dwijayani

Journal of Indonesian Health Policy and Administration

: The government of Bekasi City has released specific policies related to PSBB, which started from April 15, 2020, until the fifth amendment that will be over on July 2, 2020, due to the high prevalence of confirmed COVID-19 cases in Bekasi City. Methods: Our study using a combination approach between Media Content Analysis for collecting the secondary data and SWOT analysis plus Trias Policy Analysis in evaluation and identification the role of several elements related to specific policies released from the Government of Bekasi City. Result: There are some best recommendations based on our SWOT analysis and Trias Policy …

Impact Of Covid Responses On Brand Performance, Emy Rezkalla

Theses and Dissertations

The main objective of this study is to understand and evaluate whether COVID responses have a significant positive impact on brand performance. Accordingly, the proposed conceptual model focused on the top four COVID-19 responses: donations in cash, donations in kind, customer service, and employers/suppliers and evaluated the impact of each proposed response on brand value, brand growth, and brand ranking in 2020 versus 2019.

The research question of this paper is, Do COVID responses (customer service, employers/suppliers, donations in kind, and donations in cash) have a significant positive impact on brand performance (brand value, brand growth, and brand ranking vs. …

A Review Of Toolkits And Case Definitions For Detecting Enteric Fever Outbreaks In Asian And African Countries From 1965-2019, Asif Khaliq, Mohammad Tahir Yousafzai, Salman Haq, Rahima Yaseen, Sonia Qureshi, Fahad Rind, Zahra A. Padhani, Ayub Khan, Abdul Momin Kazi, Farah Naz Qamar

Department of Paediatrics and Child Health

Background: This review assessed the case definitions, diagnostic criteria, antimicrobial resistance, and methods used for enteric fever outbreaks and utilization of any unified outbreak score or checklist for early identification and response in Asia and Africa from 1965-2019.
Methods: We searched enteric fever outbreaks using PubMed, Google Scholar, and the Cochrane library. Studies describing a single outbreak event of enteric fever in Asia and Africa from 1965-2019 were reviewed. We excluded case reports, letter to editors, studies reporting typhoid in conjunction with other diseases, the Centers for Disease Control and Prevention (CDC) trip reports, the World Health Organization (WHO) bulletins …

New Dynamical Behaviour Of The Coronavirus (2019-Ncov) Infection System With Non-Local Operator From Reservoirs To People, P. Veeresha, Wei Gao, D. G. Prakasha, N. S. Malagi, E. Ilhan, Haci Mehmet Baskonus

Information Sciences Letters

The mathematical accepts while analysing the evolution of real word problems magnetizes the attention of many scholars. In this connection, we analysed and find the solution for nonlinear system exemplifying the most dangerous and deadly virus called coronavirus. The six ordinary differential equations of fractional order nurtured the projected mathematical model and they are analysed using q-homotopy analysis transform method (q-HATM). Further, most considered fractional operator is applied to study and capture the more corresponding consequences of the system, known as Caputo operator. For different fractional order, the natures of the achieved results are illustrated in plots. Lastly, the present …

Characteristics Of Social And Physical Environment Associated With And Chest Diseases Of The Circulatory System: A Comparative Study Of Different Social Strata In The Rural And Urban, Hatem A. Ahmed, M. Sery, Osama I. A. Marzouk, Mansour S. M. Loatyif, Marwan M. Abdeldayem

Information Sciences Letters

In this paper, we consider the human development as a process of expanding educational capabilities and experiences to reach a high level of production and income. The social variables are divided into age and disease - education and economic level and the hustle and disease. The study assumes the existence of significant relationship between social changes and chest diseases and circulatory system. It is observed that there are significant relationships between different factors. It is assumed that the study is a descriptive study and analytical comparison relied on social survey and used the interview. It is shown that the considered …

Clinical Management Of Covid-19: A Review Of Pharmacological Treatment Options, A. M. Heustess, M. A. Allard, D. K. Thompson, P. S. Fasinu

Pharmaceutical Sciences

No abstract provided.

Promoting Antibiotic Stewardship In Primary Care Setting: An Evaluation Process Of Treatment Practices For Uncomplicated Urinary Tract Infections In Premenopausal Non-Pregnant Women, Ira Amayun

Doctor of Nursing Practice (DNP) Projects

Problem

Inappropriate antibiotic prescribing increases the prevalence of antibiotic resistance. While evidence-based practice guidelines can reduce antibiotic use, inconsistent adherence to these guidelines results in ineffective treatment, increased cost, and increasing antibiotic resistance.

Context

At Athena Med-Monterey, a multi-provider primary care clinic where approximately 90% of the patients are women, written guidelines for uncomplicated urinary tract infections (uUTIs) in premenopausal non-pregnant women (PrMNPW) are lacking. In addition, there are no processes for assessing adherence to clinical guidelines.

Interventions

The advanced practice nurse (APN) led a quality improvement process to assess and promote adherence to practice guidelines using a small test …