Digital Commons Network^™

Protein Prenylation And Hsp40 In Thermotolerance Of Plasmodium Falciparum Malaria Parasites, Emily S Mathews, Andrew J Jezewski, Audrey R Odom John

Open Access Publications

During its complex life cycle, the malaria parasite survives dramatic environmental stresses, including large temperature shifts. Protein prenylation is required during asexual replication of Plasmodium falciparum, and the canonical heat shock protein 40 protein (HSP40; PF3D7_1437900) is posttranslationally modified with a 15-carbon farnesyl isoprenyl group. In other organisms, farnesylation of Hsp40 orthologs controls their localization and function in resisting environmental stress. In this work, we find that plastidial isopentenyl pyrophosphate (IPP) synthesis and protein farnesylation are required for malaria parasite survival after cold and heat shock. Furthermore, loss of HSP40 farnesylation alters its membrane attachment and interaction with proteins in …

The Impact Of Emergency Response Trainees During The Ebola Outbreak In Sierra Leone, 2014-2016, Abbey Whitcomb

Undergraduate Honors Theses

This research aimed to address the impact of non-health trainees as a part of the emergency health response during the Ebola outbreak within Sierra Leone. The non-health trainees, including sanitation workers within health settings, ambulance drivers, burial teams, prison officers, community engagement staff, border officers, traditional birth assistants, etc. was contrasted with individuals receiving clinical and patient-care training. The data were taken from weekly situation reports published by the Internal Organization for Migration in 2015. Using a negative binomial model, we sought to determine the incidence rate ratio of weekly cases and deaths as a result of new trainees. Trainees …

Weather And Crime: New York State, Yuna Kim

Student Theses

The present study assesses the degree to which temperature affects the crime rates in all 62 counties in the State of New York. Five different crimes (i.e., robbery, aggravated assault, burglary; larceny, and motor vehicle theft) for the year 2019 were selected from the Division of Criminal Justice Services of New York to be examined. The current study examined whether the rate of these crimes was associated with the changes in weather, with the assumption that higher weathers would lead to higher property and violent crimes, when controlling for the effect of various control variables. The findings suggest that the …

Uab Partners With Adph To Launch The Alabama Regional Center For Infection Prevention And Control, Staff

Browse All News

No abstract provided.

Alaska Fetal Alcohol Spectrum Disorders Data Systems Development: Gaps, Opportunities, & Recommendations, Travis Hedwig, Virginia Miller, David Parker, Troy C. Payne, Andrew Gonzalez, Yevgenii Kisarauskas, Avram Slone, Paulsen Brown, Hattie Harvey, Vanessa Hiratsuka, Danielle Reed, Curtis Smith, Karen Ward

AJiC Reports

The report, "Alaska Fetal Alcohol Spectrum Disorders Data Systems Development," was prepared for the Alaska Mental Health Trust Authority by the University of Alaska Anchorage (UAA) College of Health. This report was a partnership between the Alaska Justice Information Center, the Center for Alcohol and Addiction Studies, the Center for Human Development, and the Division of Population Health Sciences.

Direct Maternal Morbidity And The Risk Of Pregnancy-Related Deaths, Stillbirths, And Neonatal Deaths In South Asia And Sub-Saharan Africa: A Population-Based Prospective Cohort Study In 8 Countries, Imran Ahmed, Shabina Ariff, Zulfiqar Ahmed Bhutta, Muhammad Ilyas, Fyezah Jehan, Usma Mehmood, Karim Muhammad, Muhammad Imran Nisar, Sajid Bashir Soofi, Yaqub Wasan, Anita K. M. Zaidi

Woman and Child Health

Background: Maternal morbidity occurs several times more frequently than mortality, yet data on morbidity burden and its effect on maternal, foetal, and newborn outcomes are limited in low- and middle-income countries. We aimed to generate prospective, reliable population-based data on the burden of major direct maternal morbidities in the antenatal, intrapartum, and postnatal periods and its association with maternal, foetal, and neonatal death in South Asia and sub-Saharan Africa.
Methods and findings: This is a prospective cohort study, conducted in 9 research sites in 8 countries of South Asia and sub-Saharan Africa. We conducted population-based surveillance of women of reproductive …

Emerging Advances Of Nanotechnology In Drug And Vaccine Delivery Against Viral Associated Respiratory Infectious Diseases (Varid), Amir Seyfoori, Mahdieh Shokrollahi Barough, Pooneh Mokarram, Mazaher Ahmadi, Parvaneh Mehrbod, Alireza Sheidary, Tayyebeh Madrakian, Mohammad Kiumarsi, Tavia Walsh, Kielan D Mcalinden, Chandra C Ghosh, Pawan Sharma, Amir A Zeki, Saeid Ghavami, Mohsen Akbari

Center for Translational Medicine Faculty Papers

Viral-associated respiratory infectious diseases are one of the most prominent subsets of respiratory failures, known as viral respiratory infections (VRI). VRIs are proceeded by an infection caused by viruses infecting the respiratory system. For the past 100 years, viral associated respiratory epidemics have been the most common cause of infectious disease worldwide. Due to several drawbacks of the current anti-viral treatments, such as drug resistance generation and non-targeting of viral proteins, the development of novel nanotherapeutic or nano-vaccine strategies can be considered essential. Due to their specific physical and biological properties, nanoparticles hold promising opportunities for both anti-viral treatments and …

The Effects Of Agrochemical Pesticide Applications On Target And Off-Target Species In Aquatic Ecosystems, Bryan K. Delius

USF Tampa Graduate Theses and Dissertations

The increase in the global human population is driving agricultural expansion, which increases the likelihood and degree by which agrochemicals impact aquatic systems. It is projected that by 2100 the global human population will exceed 11 billion, and to feed the increased human population, the necessary increase in agricultural infrastructure is estimated to double irrigation, nearly triple fertilizer applications, and increase pesticide applications by tenfold. It stands to reason that wetlands impacts from agriculture are also likely to increase as the industry expands its operation to meet the globally growing demand for food.

Wetlands are highly productive habitats that not …

Tocilizumab And Covid-19: A Meta-Analysis Of 2120 Patients With Severe Disease And Implications For Clinical Trial Methodologies, Azza Sarfraz, Zouina Sarfraz, Muzna Sarfraz, Hinna Aftab, Zainab Pervaiz

Department of Paediatrics and Child Health

Background/aim: Since the outbreak of the COVID-19, numerous therapies to counteract this severe disease have emerged. The benefits of Tocilizumab for severely infected COVID-19 patients and the methodologies of ongoing clinical trials are explored.
Materials and methods: A systematic search adhering to PRISMA guidelines was conducted in PubMed, Cochrane Central, medRxiv, and bioRxiv using the following keywords: “Tocilizumab,” “Actemra,” “COVID-19.” An additional subsearch was conducted on Clinicaltrials.gov to locate ongoing tocilizumab trials.
Results: A total of 13 studies were included in the meta-analysis comprising 2120 patients. The treatment group had lower mortality compared to the control group (OR = 0.42, …

Profiling Pretomanid As A Therapeutic Option For Tb Infection: Evidence To Date., Stephani L. Stancil, Fuad Mirzayev, Susan M. Abdel-Rahman

Manuscripts, Articles, Book Chapters and Other Papers

Tuberculosis (TB) is the most deadly infectious disease globally. Although most individuals achieve a cure, a substantial portion develop multi-drug resistant TB which is exceedingly difficult to treat, and the number of effective agents is dwindling. Development of new anti-tubercular medications is imperative to combat existing drug resistance and accelerate global eradication of TB. Pretomanid (PA-824) represents one of the newest drug classes (ie, nitroimidazooxazines) approved in 2019 by the United States Food and Drug Administration as part of a multi-drug regimen (with bedaquiline and linezolid, BPaL) and recommended by the World Health Organization (WHO) to treat extensively-resistant (XR-TB) and …

2021-06-26_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Cardiac Transplant Recipient With Covid-19 Induced Acute Hypoxic Respiratory Failure: A Case Report, Ariyon Schreiber, Kalaimani Elango, Kimberly Hong, Chowdhury Ahsan

School of Medicine Faculty Research

Background: Heart transplant recipients represent a particularly vulnerable patient population to the novel coronavirus disease 2019 (COVID-19) due to chronic immunosuppression and high rates of comorbidities. Currently, data are limited and evidence to guide management of heart transplant recipients with COVID-19 is sparse. In this case report, we provide a summary of the current literature as well as an in-depth analysis of our clinical decision-making. Case summary: A 67-year-old female who underwent cardiac transplantation 1 year prior was found to have acute hypoxic respiratory failure due to COVID-19. Her immunosuppressant medications were modulated with discontinuation of mycophenolate and titration of …

Brain Fog: Understanding The Neurocognitive Symptoms Of Covid-19, Kavita Sharma

Aurora GME

•Hospitalized COVID 19 patients commonly have neurologic complications.

•Myalgias, headache, encephalopathy, and dizziness may be most common, occurring in approximately one third of patients in China, Europe, and the United States.

•Dysgeusia or anosmia commonly reported.

•Stroke, movement disorders, motor and sensory deficits, ataxia, and seizures appear uncommon.

•Neurologic complications are higher in critically ill ICU patients

•This talk was to help highlight the pathophysiology of neuro COVID to shed insights on the care of patients with neurological symptoms post COVID

2021-06-25_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

New Diagnosis Of X-Linked Agammaglobulinemia Presenting As Multi-Focal Acute Pseudomonal Osteomyelitis And Septic Arthritis In A 16-Month Old Boy: A Case Report, Walter Dehority

Western Journal of Orthopaedics

A previously healthy 16-month-old boy presented with 5 days of fever, a limp favoring his right side, and swelling and erythema of the dorsal left foot and left great toe. Contrasted magnetic resonance imaging revealed septic arthritis of the left knee, the interphalangeal joint of the left great toe, and the left subtalar and ankle joints. He had osteomyelitis of the left talus and intraosseous abscess formation in the left calcaneus. Cultures of the blood, left knee synovial fluid, and abscess fluid all showed growth of Pseudomonas aeruginosa. He was subsequently diagnosed with X-linked agammaglobulinemia with a novel mutation in …

Circumcision As An Intervening Strategy Against Hiv Acquisition In The Male Genital Tract, Adhikarimayum Lakhikumar Sharma, Joseph Hokello, Mudit Tyagi

Center for Translational Medicine Faculty Papers

Unsafe sex with HIV-infected individuals remains a major route for HIV transmission, and protective strategies, such as the distribution of free condoms and pre-or post-prophylaxis medication, have failed to control the spread of HIV, particularly in resource-limited settings and high HIV prevalence areas. An additional key strategy for HIV prevention is voluntary male circumcision (MC). International health organizations (e.g., the World Health Organization, UNAIDS) have recommended this strategy on a larger scale, however, there is a general lack of public understanding about how MC effectively protects against HIV infection. This review aims to discuss the acquisition of HIV through the …

Successful Aging In Adults Who Stutter: Exploring Predictors Of Physical And Mental Health-Related Quality Of Life, Amanda Kelly

USF Tampa Graduate Theses and Dissertations

This study was conducted to investigate predictors of physical and mental health quality of life in aging adults who stutter (AWS). Our goal was to identify factors contributing to successful aging in this talker group. The aging population is expected to increase exponentially over the next twenty years. Factors influencing self-perceived health-related quality of life have yet to be investigated in aging AWS.

An online survey was completed by a total of 40 AWS, age 50 years and older, recruited from the Greater Tampa Bay region and nationally. The survey comprised multiple measures that probed for information regarding self-perceived health …

Flow Visualization And Aerosol Characterization Of Respiratory Jets Exhaled From A Mannequin Simulator, Sindhu Reddy Mutra

USF Tampa Graduate Theses and Dissertations

It is important to understand the airborne transmission of infectious diseases due to the COVID-19 pandemic. Physical experiments were conducted to understand the dispersion of aerosols emitted from a mannequin simulator replicating human tidal breathing through the nose and mouth with and without a protective face mask in an enclosed space. Flow patterns are observed via high-speed visualization, and the concentration and size distribution of the particles is measured as a function of distance from the mannequin using an optical particle sizer. Masks were shown to effectively reduce the horizontal dispersion of aerosol for both mouth and nose breathing. Further, …

The Extended Parallel Processing Model (Eppm) And Risk Perceptions Of Twitter Messages Related To Covid-19, Muhammad E. Rasul

USF Tampa Graduate Theses and Dissertations

Since its genesis, the novel coronavirus or COVID-19 has claimed millions of lives across the world and has infected many more. The population in the US experienced one of the worst outbreaks of COVID-19 in the world, with the number of deaths rising monolithically at one point. Although the development and inoculation of a large number of the public has helped, newer variants threaten to revitalize the growth and spread of COVID-19. Scholars have extensively studied health messages related to COVID-19 in a variety of contexts. However, little attention has been paid to the risk perceptions of health messages related …

Endothelial Senescence And Chronic Fatigue Syndrome, A Covid-19 Based Hypothesis, Adonis Sfera, Carolina Osorio, Carlos M. Zapata Martín Del Campo, Shaniah Pereida, Jose Campo Maldonado, Zisis Kozlakidis

School of Medicine Publications

Myalgic encephalomyelitis/chronic fatigue syndrome is a serious illness of unknown etiology, characterized by debilitating exhaustion, memory impairment, pain and sleep abnormalities. Viral infections are believed to initiate the pathogenesis of this syndrome although the definite proof remains elusive. With the unfolding of COVID-19 pandemic, the interest in this condition has resurfaced as excessive tiredness, a major complaint of patients infected with the SARS-CoV-2 virus, often lingers for a long time, resulting in disability, and poor life quality. In a previous article, we hypothesized that COVID-19-upregulated angiotensin II triggered premature endothelial cell senescence, disrupting the intestinal and blood brain barriers. Here, …

Covid-19: Dental Aerosol Contamination In Open Plan Dental Clinics And Future Implications, K Ali, M Raja

Peninsula Dental School

No abstract provided.

Singapore’S Quarantine Rhetoric And Human Rights In Emergency Health Risks, Huiling Ding, Elizabeth A. Pitts

Journal of Rhetoric, Professional Communication, and Globalization

When Severe Acute Respiratory Syndrome (SARS) began spreading in Asia in March 2003, many affected countries and areas scrambled to mobilize public health resources and rushed to find effective ways to contain the virus within their territories. In late March and April of the same year, the World Health Organization (WHO) added numerous East and Southeast Asian countries and regions to its list of areas affected by SARS: mainland China, Hong Kong, Vietnam, Singapore, and Taiwan. Singapore was among the first countries to eradicate SARS and was taken off the WHO list on May 30, 2003.

Understanding Vulnerable Populations, Dakota Caldwell

CPAR Presents: A Data and Research Series for Community Impact

Human mobility, in its different manifestations — international and domestic migration; refugees, asylum seekers, and displaced populations; and human trafficking — is at the center of many political and public debates. In two research presentations by UNO faculty, the demographics of highly mobile populations will be explored as well as the impacts of mobility on communities in Nebraska.

Minority Health Disparities In A 21st-Century Pandemic: A Comprehensive Report Of Project Research Focused On New York, Teresa Harrison, Theresa Pardo, Jordan Carleo-Evangelist, Lynn Warner

Understanding and eliminating minority health disparities in a 21st-century pandemic: A White Paper Collection

The COVID-19 pandemic has exacted a starkly unequal toll on New Yorkers of color – both in terms of the virus itself and the accompanying social and economic impacts of the pandemic. These are not separate issues. They stem from the structural racism embedded in American society. While our work begins by establishing a statistical baseline for how the virus’s unequal toll played out in the early months of the COVID-19 pandemic in New York, any analysis of these disparities that looks solely at hospitalizations and deaths misses a tremendous piece of this tragic and preventable story. Minority health disparities …

Perceived Benefits Matter The Most In Covid-19 Preventive Behaviors: Empirical Evidence From Okara District, Pakistan, Gulzar H. Shah, Ansar Ali Faraz, Hina Khan, Kristie Cason Waterfield

Health Policy & Community Health: Faculty Publications

The 2019 coronavirus disease (COVID-19), caused by the SARS-CoV-2 virus has affected the social determinants of health, worsening health inequities and deteriorating healthcare capacities around the globe. The objective of this study is to investigate the COVID-19 prevention behaviors within the framework of the Health Belief Model in the city of Depalpur in the Okara District of Pakistan in May 2020. Using an observational, cross-sectional, and quantitative study design, a faceto- face field survey was conducted during the epidemic of COVID-19 in district Okara, Pakistan. A sample of 500 adults was selected from the city of Depalpur the in Okara …

Transparent Planar Micro-Electrode Array For In-Vitro Electric Field Mediated Gene Delivery, Raj Himatlal Shah

USF Tampa Graduate Theses and Dissertations

Gene delivery is the process of delivering the modified gene into the human cell. There are two types of gene delivery depending on where the target cells are. The in-vivo gene delivery deals with delivering the altered genes into the cells while still in the host body. While another approach is to extract the cells from the host body, transfer the modified gene into cells and then put these cells back into the host body, this approach is called the ex-vivo method.

A vector is a carrier that carries the modified gene to the host cell or body. Hence, depending …

Streptococcus Mutans Lacking Sufcdsub Is Viable, But Displays Major Defects In Growth, Stress Tolerance Responses And Biofilm Formation, Kassapa Ellepola, Xiaochang Huang, Ryan P. Riley, Jacob P. Bitoun, Zezhang Tom Wen

School of Dentistry Faculty Publications

Streptococcus mutans appears to possess a sole iron-sulfur (Fe-S) cluster biosynthesis system encoded by the sufCDSUB cluster. This study was designed to examine the role of sufCDSUB in S. mutans physiology. Allelic exchange mutants deficient of the whole sufCDSUB cluster and in individual genes were constructed. Compared to the wild-type, UA159, the sufCDSUB-deficient mutant, Δsuf::kanr, had a significantly reduced growth rate, especially in medium with the absence of isoleucine, leucine or glutamate/glutamine, amino acids that require Fe-S clusters for biosynthesis and when grown with medium adjusted to pH 6.0 and under oxidative and nitrosative stress conditions. Relative to UA159, Δsuf::kanr …

A New Age Of Telehealth: Pediatric Speech-Language Pathology Services During The Covid-19 Pandemic And Beyond, Deborah R. Campbell

USF Tampa Graduate Theses and Dissertations

The COVID-19 pandemic potentially changed the landscape of how speech-language pathologists provide services. Prior to March 2020, pediatric speech-language therapy provided via telehealth was limited; however, the COVID-19 pandemic caused a worldwide conversion from in-person care to a remote service delivery model. This conversion brought to the fore possible benefits and utility of telehealth use. Yet, clinicians potentially experienced barriers to its use, including the lack of validity and reliability evidence for remote administration of several pediatric assessments. For the viability of remotely delivered speech-language services to continue and evolve in a post-pandemic world, further research is needed to identify …

The Prospect Of Nanoparticle Systems For Modulating Immune Cell Polarization During Central Nervous System Infection, Lee E. Korshoj, Wen Shi, Bin Duan, Tammy Kielian

Journal Articles: Pathology and Microbiology

The blood-brain barrier (BBB) selectively restricts the entry of molecules from peripheral circulation into the central nervous system (CNS) parenchyma. Despite this protective barrier, bacteria and other pathogens can still invade the CNS, often as a consequence of immune deficiencies or complications following neurosurgical procedures. These infections are difficult to treat since many bacteria, such as Staphylococcus aureus, encode a repertoire of virulence factors, can acquire antibiotic resistance, and form biofilm. Additionally, pathogens can leverage virulence factor production to polarize host immune cells towards an anti-inflammatory phenotype, leading to chronic infection. The difficulty of pathogen clearance is magnified by …

On The Road From Phenotypic Plasticity To Stem Cell Therapy., Lorraine Iacovitti

Farber Institute for Neuroscience Faculty Papers

In 1981, I published a paper in the first issue of The Journal of Neuroscience with my postdoctoral mentor, Richard Bunge. At that time, the long-standing belief that each neuron expressed only one neurotransmitter, known as Dale's Principle (Dale, 1935), was being hotly debated following a report by French embryologist Nicole Le Douarin showing that neural crest cells destined for one transmitter phenotype could express characteristics of another if transplanted to alternate sites in the developing embryo (Le Douarin, 1980). In the Bunge laboratory, we were able to more directly test the question of phenotypic plasticity in the controlled environment …