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Congenital Heart Defects And The Expression Of Ccdc141, Savanna Tillman

Honors Theses

Congenital heart defects (CHDs) are one of the most prevalent types of birth defects in the United States. Both environmental and genetic components are known to contribute to the development of CHDs. One of the ways toxins present in the environment cause CHDs is by disrupting the expression of genes known to be vital in normal cardiac morphogenesis. Thus, the identification of both toxins that cause birth defects in cardiac development and genes expressed during heart development is crucial in order to fully understand the relationship between environment and genetics as they relate to CHD. Due to their external development, …

Effectiveness Of Equine Assisted Psychotherapy & Learning For Substance Use Disorder Treatment In College-Age Young Adults, Katherine Abigail Cagle-Holtcamp

Theses and Dissertations

With overdose deaths and residential addiction treatment admittance increasing, more treatment options are necessary to meet the demand of services. Equine assisted psychotherapy and learning (EAPL) is a relatively new therapeutic tool in addiction treatment for individuals battling substance use disorder (SUD), and thus, lacks a solid evidence base to be implemented consistently and effectively. The purpose of this dissertation was to determine the effectiveness of EAPL in creating an emotionally safe environment for learning for college-age young adults with a particular focus on those struggling with SUD. This was accomplished in a series of projects focused on: 1) implementing …

Model Curricula: Embry-Riddle Aeronautical University

Online Journal of Space Communication

Many universities have added courses and curricula related to satellites and space. A search of the Internet reveals that few of these are designated degree programs in space studies degree, rather they are traditional programs offering courses and concentrations which involve study of space and space applications from several perspectives. The Internet search also reveals a large variation in both the titles and the curricula for these programs. The author has sought to standardize definitions, identify workable program names and suggest core courses. Five programs and their core courses are outlined for consideration.

The Four Deaths Of Ged, John Rosegrant

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

A grim land of the dead holds a central place in Le Guin’s Earthsea series. This underworld, its relationship with the land of the living, and its final transformation, have important psychological meanings: Le Guin demonstrates that to develop a self that is integrated, differentiated, and vibrant, not only does the conscious mind need connection with the unconscious, but the unconscious mind needs connection with the conscious ego as well. Le Guin further demonstrates that these connections between the conscious and unconscious mind must take different forms across the lifespan. The arc of Ged’s story provides the rare opportunity to …

Application Of An Evidence-Based, Out-Patient Treatment Strategy For Covid-19: Multidisciplinary Medical Practice Principles To Prevent Severe Disease☆, Elliot M. Frohman, Nicole R. Villemarette-Pittman, Adriana Rodriguez, Robert Glanzman, Sarah Rugheimer, Oleg Komogortsev, Scott S. Zamvil, Roberto A. Cruz, Thomas C. Varkey, Ashley N. Frohman

School of Medicine Publications

The COVID-19 pandemic has devastated individuals, families, and institutions throughout the world. Despite the breakneck speed of vaccine development, the human population remains at risk of further devastation. The decision to not become vaccinated, the protracted rollout of available vaccine, vaccine failure, mutational forms of the SARS virus, which may exhibit mounting resistance to our molecular strike at only one form of the viral family, and the rapid ability of the virus(es) to hitch a ride on our global transportation systems, means that we are will likely continue to confront an invisible, yet devastating foe. The enemy targets one of …

Induced Voltage And Current Simulation Of 380 V Lineparallel Operating Under 330 Kv Doublecircuit Transmission Lines, Yunlong Zheng, Richeng Luo, Ming Zou, Zhiqi Li, Jia Hou

Journal of Electric Power Science and Technology

In the Northwest Economic Corridor region, the distribution lines with the low voltage ride through is built and parallel operates under high voltage lines in order to save the land occupation and improve the economic benefit. However, during the outage maintenance process of the low voltage line, the induction voltage and current generated by electrostatic effect and electromagnetic coupling of the multicircuit highvoltage transmission lines may threaten the safety of maintenance personnel. On this background, the normal operation of LuoshanLingzhou 330kV transmission line in Northwest China is taken as an example and an ATPEMTP simulation model is built in this …

Removal Of Antibiotics And Nutrients By Vetiver Grass (Chrysopogon Zizanioides) From A Plug Flow Reactor Based Constructed Wetland Model, Saumik Panja, Dibyendu Sarkar, Zhiming Zhang, Rupali Datta

Michigan Tech Publications, Part 1

Overuse of antibiotics has resulted in widespread contamination of the environment and triggered antibiotic resistance in pathogenic bacteria. Conventional wastewater treatment plants (WWTPs) are not equipped to remove antibiotics. Effluents from WWTPs are usually the primary source of antibiotics in aquatic environments. There is an urgent need for cost-effective, environment-friendly technologies to address this issue. Along with antibiotics, nutrients (nitrogen and phosphorus) are also present in conventional WWTP effluents at high concentrations, causing environmental problems like eutrophication. In this study, we tested vetiver grass in a plug flow reactor-based constructed wetland model in a greenhouse setup for removing antibiotics ciprofloxacin …

Hyperoxia-Induced Cardiac Pathophysiology In Guinea Pig Hearts, Zain Ul Abidin

USF Tampa Graduate Theses and Dissertations

Hyperoxia, is regularly introduced to critically ill patients in ICU. Nevertheless, recent studies have shown the negative effects of this treatment on patients in critical care, including increased rates of lung and cardiac injury and thereby high in-hospital mortality. Large part of the literature related to hyperoxia was majorly focused on lung injury, with no or minimal investigations on cardiac injury. Our lab is the first to investigate the effect of hyperoxia on cardiac pathophysiology in mice and showed that mice exposed to hyperoxia for 3 days demonstrated brady-arrhythmia, cardiac hypertrophy, QTc prolongation along with other electrical remodeling and functional …

Disabled Epistemologies: Failures Of Knowledge And Care In Shakespeares's Merchant Of Venice And Othello, Amie Elisabeth Wambach

Theses and Dissertations

The presence of disabled characters like blind Gobbo in The Merchant of Venice and epileptic Othello are handy physical metaphors for the failures of epistemology that occur in both plays. Disability is often construed as a sort of saboteur of knowledge—disability of all kinds inhibiting the ability to perceive the world as an abled person would. But disability also produces a new, necessary sort of knowledge in order to survive and thrive in an unaccommodating world. A disabled epistemology suggests that knowing is contingent on individual, specific experience of the world. Tied to this issue of disabled epistemology is the …

Decoding Gut Microbial Metabolites Through G-Protein Coupled Receptor (Gpcr) Activation, Phu Khat Nwe

Yale Graduate School of Arts and Sciences Dissertations

The microbiome encodes for a complex web of metabolites of which scientists are just starting to deconvolute. While a lot of focus has been on investigating the implications of the microbial metabolome on health and disease physiologies, we have merely uncovered the tip of the interactome of microbes and host G-Protein Coupled Receptors (GPCRs). Early literature has reported a plethora of short chain fatty acids fermented by dietary fibers acting as GPCR agonists. A few other studies have showcased that gut microbes produced N-acyl amides and secondary bile acids mimicking host ligands and therefore interacting with these GPCRs. Chapter 2 …

Macrophage Mechanosensing Of The Tissue Environment And Signal Integration Through The Cytoskeleton, Matthew Lowell Meizlish

Yale Graduate School of Arts and Sciences Dissertations

The extracellular matrix (ECM) is an organized assembly of proteins and polysaccharides that is produced by cells and forms the physical environment in which cells reside. Together, diverse cell types and their surrounding extracellular matrix form units of organization known as tissues, which make up organs. The ECM gives rise to the particular architecture and mechanical properties of each organ. During tissue repair, cells known as myofibroblasts deposit large quantities of ECM, in order to reconstruct the injured tissue. In normal tissue repair, that reparative phase is followed by a resolution phase, in which cells such as macrophages degrade and …

Discovery Of Host-Microbiota Interactions, Connor Rosen

Yale Graduate School of Arts and Sciences Dissertations

The microbiota, comprising the trillions of microorganisms that colonize barrier tissues, exert profound effects on host health and disease. Microbial effects on host physiology have been illuminated by a wealth of sequencing-based approaches that enumerate bacterial species, strains, genes, and products (collectively, “multi-omics” approaches) at different tissue sites and in different human populations. Microbes may influence local physiology at their site of residence, as well as having systemic effects including perturbation of organism-wide metabolism, with wide-ranging consequences. The molecular mechanisms by which microbes mediate both local and systemic effects, however, remain mostly unclear. This is in part due to technological …

Improving The Nurse Patient Assignment Process On A Medical Surgical Unit, Kevin K. Mcewan

Doctor of Nursing Practice Projects

Background: Nurse patient assignments on an adult medical surgical unit at a community hospital are often accomplished with inconsistent processes and rationales. Each charge nurse utilizes individualized processes to determine which patients will be best teamed-up and assigned to the available nurses. There are frequently no acuity measurements system or set criteria by which the number or types of patients can or should be assigned to any given nurse, nor are staff skill or competency considered in the assignment process.

Project Design: A pilot project was conducted on a medical/surgical unit. The project utilized the American Association of Critical Care …

Structural And Functional Characterization Of Lipid-Derived Molecules From The Human Microbiome, Woo Young Cho

Yale Graduate School of Arts and Sciences Dissertations

Scientific evidence for the contribution of the human microbiome to the promotion of human health and disease has been rapidly accumulating. With advances in sequencing technologies and bioinformatics, more specific correlations can be made between certain bacterial strains and/or their genes to specific disease phenotypes. However, the molecular mechanisms by which bacteria are able to influence human health remains largely elusive. Bacteria are known to interact with their environment by production and modulation of small molecules. Bacterially-produced lipid-derived molecules play important signaling roles and modulate eukaryotic cellular responses through the activation of various receptors.

Illuminated Magazine, School Of Graduate Studies, East Tennessee State University

Illuminated: Graduate Student Research Magazine

From The Graduate School; Efficacy of a New Antimicrobial Gel for Burn Treatment, [Tasha Nelson, Biology, MS]; Where are they now? [Featuring: Eric Hart]; The Cost of Delays: A Step Toward Easing the Burden of Road Construction Costs for Road Users, [Jeremiah Adebiyi, Engineering Technology, MS]; Where are they now? [Featuring: Nicholas Andal]; The Show Must Go On: ETSU’s 3MT® Competition Goes Virtual; Where are they now? Featuring: [Jingru Sun and Jessica Slade]; Coping with Grief: Understanding the Lived Experiences of Fathers Who Have Lost a Child, [Dynisha Wigginson, Nursing, PhD]; Where are they now? [Featuring: Gina …

Comparison Of Energy Expenditure Observed Between Scheduled Activities In Collegiate Team-Sport Female Athletes, Jessica M. Moon, Hannah A. Zabriskie, Patrick S. Harty, Bradley S. Currier, Julia C. Blumkaitis, Richard A. Stecker, Andrew Jagim, Chad M. Kerksick

Faculty Scholarship

Energy needs of female team-sport athletes are poorly understood with no evidence highlighting differences present between scheduled activities. The purpose of this study was to examine the difference in energy expenditure between NCAA Division II female basketball (BBALL) and lacrosse (LAX) athletes during different scheduled team activities. Female BBALL (n = 13; 19.8 ± 1.3 yrs; 173.9 ± 13.6 cm; 74.6 ± 9.1kg; 27.1 ± 3.2%fat) and LAX (n = 20; 20.4 ± 1.8yrs; 168.4 ± 6.6cm; 68.8 ± 8.9kg; 27.9 ± 3.1%fat) athletes were outfitted with heart rate and activity monitors during four consecutive days on five different occasions …

Acute Mountain Sickness, Efrain De Leon Angon

Student Publications

Overview of Acute Mountain Sickness including Diagnosis, risk factors and treatment/prevention, as well as the pathophysiology effects of AMS.

Fabrication Of Chemically-Functionalized 3dprinted Porous Scaffolds For Biomedical Applications, Eiman Hamed Alblooshi

Theses

Hard tissues, such as bone and teeth, are natural composites of collagen nanofibers that are reinforced by inorganic calcium phosphate Nano crystallites, in the form of nanocomposites. The interlocking between these components in hard tissues explains their unique characteristics. Bone is mainly classified into two major types; compact and cancellous depending on the extent of porosity. Fractures in the compact bone can be treated using bone fixation implants, such as rods, screws, and plates, or can be totally replaced by bone implants if complete substitution is required. Cancellous bone, on the other hand, is highly porous and its substitution with …

Evaluating A New Logical Argument From Evil, Bruce Langtry

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Activity-Dependent Regulation Of Extracellular Ube3a In A Novel Angelman Syndrome Rat Model, Andie Dodge

USF Tampa Graduate Theses and Dissertations

Angelman Syndrome (AS) is a rare genetic and neurologic disorder affecting approximately 1 in every 15,000 people. This disorder is characterized by seizures, absence of speech, motor and cognitive deficits, ataxia, and notably an abnormal happy demeanor with frequent smiling and laughter. A neuron-specific loss of function of the maternal allele of UBE3A, encoding for an E3 ubiquitin ligase, leads to the manifestation of AS. There are currently no cures for AS and few therapeutic options to abate symptoms. Although much investigation is required, research using the null mutation AS mouse model suggests a plausible case for pharmacological intervention.

Major …

A Millifluidic Perfusion Cassette For Studying The Pathogenesis Of Enteric Infections Using Ex-Vivo Organoids, Reid L Wilson, Sarah A Hewes, Anubama Rajan, Shih-Ching Lin, Carolyn Bomidi, Takanori Iida, Mary K Estes, Anthony W Maresso, K Jane Grande-Allen

Faculty, Staff and Students Publications

To generate physiologically-relevant experimental models, the study of enteric diarrheal diseases is turning increasingly to advanced in vitro models that combine ex vivo, stem cell-derived "organoid" cell lines with bioengineered culture environments that expose them to mechanical stimuli, such as fluid flow. However, such approaches require considerable technical expertise with both microfabrication and organoid culture, and are, therefore, inaccessible to many researchers. For this reason, we have developed a perfusion system that is simple to fabricate, operate, and maintain. Its dimensions approximate the volume and cell culture area of traditional 96-well plates and allow the incorporation of fastidious primary, stem …

Uterine Contractions In Rodent Models And Humans, Manasi Malik, Michelle Roh, Sarah K England

2020-Current year OA Pubs

Aberrant uterine contractions can lead to preterm birth and other labour complications and are a significant cause of maternal morbidity and mortality. To investigate the mechanisms underlying dysfunctional uterine contractions, researchers have used experimentally tractable small animal models. However, biological differences between humans and rodents change how researchers select their animal model and interpret their results. Here, we provide a general review of studies of uterine excitation and contractions in mice, rats, guinea pigs, and humans, in an effort to introduce new researchers to the field and help in the design and interpretation of experiments in rodent models.

Gardner-Webb Officials Announce Winners Of Full-Tuition Ignite Excellence Scholarships, Office Of University Communications

Gardner-Webb NewsCenter Archive

Admissions officials at Gardner-Webb University have announced the 2021 winners of the Ignite Excellence Scholarships. Selected from a field of 200 finalists, each of the eight recipients receive a full-tuition scholarship that honors their exemplary academic achievements. The average Grade Point Average (GPA) of these students is 4.45. The award covers the cost of tuition for fall and spring semesters and is valued at $31,220 per academic year.

Miraculous Monstrosity: Birth And Female Sexuality In The Illuminated Scivias And Cloisters Apocalypse, Jenna M. Mckellips

Medieval Feminist Forum: A Journal of Gender and Sexuality

This paper compares the illuminations in two medieval apocalypses, the Cloisters Apocalypse and Hildegard von Bingen’s Scivias, to inspect their similar constructions of female sexuality, motherhood, and monstrosity. It first analyzes the monstrosity of female sexual organs found in Hildegard’s portrayal of the Church and the Mother of the Antichrist. The paper then goes on to consider the uncanny slippage between images of birth and death in the Cloisters’s depiction of John and the Woman of Revelation 12. Ultimately, the paper not only explores the monstrosity of female bodies in apocalyptic manuscripts, but also concludes that medieval women’s …

Characteristics Of Physiology And Physiology-Related Pre-Health Degree Programs In The Physiology Majors Interest Group, Yvonne Ogrodzinski, Erica A. Wehrwein, Kevin Kelly, James M. Poteracki, Valerie Vanryn, Anne R. Crecelius

Health and Sport Science Faculty Publications

The Physiology Majors Interest Group (P-MIG), a grassroots organization of educators, has collected data on the history and characteristics of Physiology and highly related undergraduate programs (ex: Human Biology, Pre-Medicine, Biomedical Sciences, etc.) that serve a common population of prehealth students. Data was obtained as part of an online survey sent out to P-MIG conference attendees at the 2017-2019 annual meetings (n=30). Participating institutions indicate that 25.9% have degrees called Physiology aligned with 28% being housed in a department of physiology, 75.9% are a Bachelor of Science program, 34.9% are affiliated with a College of Arts and Sciences, and 80% …

Studying The Efficacy Of An Injectable 3-Dimensional Fibrin Extracellular Matrix To Characterize The Effects Of Antitumor Agents On Sw620 Cells In A Microfluidic Device, Thèo Anastos

Master's Theses

Colorectal cancer is the third most common cancer in the United States and there is currently a lot of research going into new antitumor agents to kill the cancer. One method for replicating the tumor response to a drug in vivo is by creating an in vitro drug testing model to replicate the in vivo condition. This research project was conducted to determine the efficacy of testing tumor cultures in a microfluidic device as a way to provide accurate drug responses in vitro instead of using in vivo subjects in clinical trials. A total of four experiments were conducted with …

Biological Semantic Segmentation On Ct Medical Images For Kidney Tumor Detection Using Nnu-Net Framework, Andres Bergsneider

Master's Theses

Healthcare systems are constantly challenged with bottlenecks due to human-reliant operations, such as analyzing medical images. High precision and repeatability is necessary when performing a diagnostics on patients with tumors. Throughout the years an increasing number of advancements have been made using various machine learning algorithms for the detection of tumors helping to fast track diagnosis and treatment decisions. “Black Box” systems such as the complex deep learning networks discussed in this paper rely heavily on hyperparameter optimization in order to obtain the most ideal performance. This requires a significant time investment in the tuning of such networks to acquire …

Costs And Benefits Of Physical Therapy Program Implementation For Air Force Fighter Pilots, Christian G. Erneston

Theses and Dissertations

Air Force fighter pilots face risks associated with neck and spine injuries sustained while operating fighter aircraft. Studies from the flying and medical communities indicate that muscle-strengthening prehabilitative care may decrease the risk of flying related injuries in high performance aircraft pilots. For this reason, the U.S. Air Force provided $24.9M to implement the Optimizing the Human Weapon System (OHWS) program. The program provides physical therapy and strength training to fighter pilots in participating units at twenty-one Air Force bases with the intent of reducing injury rates and time out of the cockpit. From a healthcare perspective there is interest …

Lunar/Mars Exploration (Moderator: Mark Kirasich, Gateway/Hls/Ltv), Kathy Lueders, Joel Kearns, Eric Ianson, Sean Mahoney, Ian Fichtenbaum

Spaceport Summit

No abstract provided.

Ar-Based Simulation Interaction And Human Factor Assessment For Human Robot Cooperation Assembly Planning, Wang Qiang, Xiumin Fan, Qichang He, Wenmin Zhu

Journal of System Simulation

Abstract: To improve assembly efficiency, it has become a trend for traditional manual assembly workstations to be carried out human-robot collaboration transformation. To realize the safe and fast evaluation of the improvement scheme, a general human-robot collaboration simulation method and human factor evaluation method based on Augmented Reality are proposed. Four levels of human-robot collaboration assembly simulation are established. An interactive scheme between real human and virtual robot for visual detection, perception and feedback is established. A fuzzy comprehensive evaluation model of human physiological and psychological indicators for workstation design is constructed. The prototype system is developed. Taking the assembly …