Digital Commons Network^™

The Sebaceous Gland - Friend Or Foe?, Gelan Shamloul, Frederick Lombard, Marina D'Angelo, Amor Khachemoune

Research Day

Introduction: Sebaceous glands are sebum-secreting components of pilosebaceous units, that play a key role in eccrine emulsification, the impermeability of skin and hair, cytokine, chemokine, interleukin, pheromone, and fatty acid synthesis, acid mantle formation, and hormone production. Although the sebaceous gland has been heavily investigated, many advances in the physiology and pathology of the sebaceous gland have since been identified.

Objective: The primary objective of this publication was to perform an updated literature review of the embryology, evolution, structure and function, and pathophysiological disorders associated with the sebaceous gland.

Methods: We performed a literature search using PubMed database with keywords …

Neural Oscillatory Activity Serving Sensorimotor Control Is Regulated By The Mitochondrial Redox Environment In Health And Disease, Rachel Spooner

Theses & Dissertations

Despite effective regimens of combination antiretroviral therapy, individuals with HIV are still at higher risk for developing forms of cognitive impairment, with one of the most common behavioral abnormalities to manifest being motor dysfunction. This is an important consideration, as deficits in motor control likely contribute to higher-order cognitive impairments, which together, lead to functional dependencies in the ever-growing aging population of HIV-infected adults. While the neuroanatomical bases of motor dysfunction have recently been illuminated in people living with HIV (PLWH), there remains an open question regarding the molecular processes supporting the circuit-level neuronal dynamics that potentially serve these behavioral …

An Explanatory Sequential Mixed Methods Nutrition And Physical Activity Intervention Study On Changes In Knowledge, Self-Efficacy, And Outcome Expectations Of Fathers, Sarah Hortman

Theses & Dissertations

Overweight and obesity rates are a continuing concern resulting in poor health outcomes and annual healthcare costs in the billions of dollars. An upstream approach of health promotion is critical to change the focus from treatment and management to prevention of chronic disease. Preventing chronic disease through evidence-based health promotion practices incorporating educational interventions aimed at dietary and physical activity behaviors will preclude negative health outcomes including cardiovascular disease, type 2 diabetes, and hypertension.

The family environment is an important consideration in the prevention of chronic disease including obesity. Parents are role models for their children, including fathers who are …

Human Powered Vehicle Capstone, Maya L. Washington, Ryan Apolonio, Marc Sunga, John Rettenmier, Dr. Allen Wilson

Honors Thesis

In the ASME Human Powered Vehicle Challenge (HPVC), students design, develop, construct, and test different designs of human-powered vehicles. The design utilizes two wheels, the rear of which is responsible for power transmission from a pedal crank and braking through a disc and caliper. The design also utilizes the front wheel fork wheel for steering. Steering and braking are controlled by two levers on the handlebars. To determine whether the design was sufficient, it was compared to the standards set by ASME, including maximum weight, minimum speed, minimum turning radius, minimum ride distance, load testing, harness verification, and a complete …

Developing A Peer Mentoring Program For Srnas, Morgan E. Fitterer, Miranda Portwine

Doctor of Nursing Practice Projects

Faculty of a nurse anesthesia program at a Midwestern University requested evidence of the impact a peer mentoring program could make in reducing stress levels for SRNAs. To better tailor a peer mentoring program, surveys were developed and distributed to the university’s SRNAs and to program directors of CRNA programs across the country.

Based on the literature, a survey was developed and distributed to 81 SRNAs at this university to evaluate their stress and their perceptions of the impact of peer mentoring on stress. Another survey was developed and distributed to 118 program directors to learn if they have a …

2021 Spring - Commencement Program, Office Of The Registrar, East Tennessee State University

ETSU Commencement Ceremonies and Programs

No abstract provided.

Explaining Reproductive Health Disparities: Violence In The “Colorblind” Institution Of Medicine, Chineze Osakwe

Honors Scholar Theses

Medical policies have resulted in violence that has a formal role in regulating the reproductive rights of women of African descent in the United States from the Jim Crow era (circa 1965) to present day (2021), resulting in significantly racialized reproductive health disparities regardless of social or economic influences. This thesis explores why reproductive violence against African-American women persists, regardless of women’s own class and educational background. I have focused on the potential impact of two structural components that I hypothesized contributed to the perpetuation of reproductive violence against Black women and persistent health disparities. The two factors explored in …

U-251mg Spheroid Generation Using A Scaffold Based Method Protocol, Lara Carroll, Brijesh K. Tiwari, James F. Curtin, Janith Wanigasekara

Articles

3D cell culture is a technique that is used to grow cells in vitro that will mimic an in vivo environment. 3D cell models are a helpful learning tool for researchers to better understand disease mechanisms and to explore different therapeutic properties of drugs. 3D cell cultures can be developed using patient derived cancer cells. Once they have been grown, these 3D cells can be used to screen for small molecule drugs or for genetic modification in for analysis of disease pathways or to predict drug treatments toxicity or efficacy. 3D cell cultures are a big step towards the more …

Physical Well-Being And Healthy Lifestyle Options, Michael Perkins

Doctor of Nursing Practice Projects

Background

The AANA has identified stress management or wellness as a priority for all CRNA programs. The Health and Wellness Initiative put in place by the AANA in 2004 is a model designed for all SRNA programs and intended to address students’ participation in wellness events in order to combat stressors.

The primary purpose of this project was to gain information about the stress faced by SRNAs enrolled at a Midwestern University and to evaluate strategies that could help students properly deal with stress.

Methods and Evaluation

Fifty-five students participated in the survey, data were compared by year in the …

Surmounting Disembodiment: Architecture And Suicide Prevention, Jack Mcgeehan

Bachelor of Architecture Theses - 5th Year

Suicide is currently the 10th leading cause of death in the United States, more than double the number of homicide deaths. This thesis questions how architects can design more appropriately for people who are at risk for suicide in the United States. While suicide is individualistic and varies from person to person, there are consistencies that can serve as a basis for mitigating the problem and building an infrastructure for the solution. This thesis begins by examining four key cohorts that are typically high risk in the United States; veterans, the elderly, the homeless, and youths. It examines the behavioral …

Extreme Weather And Its Impacts On Human Civilizations: An In-Depth Investigation Of Causes And Effects, Jason Zabel

Senior Honors Theses

Extreme weather has impacted humanity since creation and is an important topic that deserves examination. In this thesis, the main event that is presented and analyzed is the extreme haze that clouded much of China’s skies in 2013. Further, the impacts this major event had on people, including changes in population movement, death/injury rate, and changes in atmospheric chemistry due to the high concentration of particulates are discussed. Subsequent examples that will be explored include Hurricane Katrina and the eruption of Mt. St. Helens. The main contention of this thesis is that the effects extreme weather has on human civilization …

Voluntary Alcohol Consumption And Sleep Deprivation In Rats, Aesha Khan

Masters Theses, 2020-current

Alcohol is one of the most common psychoactive drugs and has depressant effects on the central nervous system. The vast majority of research on alcohol and sleep commonly indicates chronic alcohol use has a detrimental impact on sleep architecture and homeostasis. However, less research has been conducted investigating the effects of sleep deprivation on alcohol consumption. Our lab's previous studies have looked at a potential bi-directional relationship between sleep and alcohol with promising results. However, there was concern that the method of sleep deprivation may have resulted in stress. The present study examines the effect of sleep deprivation on voluntary …

U-251mg Spheroid Generation Using Low Attachment Plate Method Protocol, Lara J. Carroll, Brijesh K. Tiwari, James F. Curtin, Janith Wanigasekara

Articles

3D cell culture is a process used to grow cells in vitro to mimic an in vivo environment. 3D cell models are very useful for understanding disease mechanisms and exploring drug therapeutics. 3D cultures can be grown from cells taken from cancer organoids in patients. Once grown, they can be used to screen for small molecule drugs or they can be genetically modified in order to analyse disease pathways or predict the toxicity or efficacy of a drug treatment. These cultures decrease the need to use animals in research and provides more reliable results as it uses human physiology. This …

Coronary Artery Disease: An Analysis Of Its Biochemical, Physiological, And Sociological Causes And Effects, Alexander Velazquez

Honors Theses

Coronary Artery Disease (CAD) is a serious condition caused by a buildup of plaque in your coronary arteries, the blood vessels that bring oxygen-rich blood to your heart. It disproportionately affects millions of Americans and thousands of Mississippians. This study presents the results of an evaluation of causation factors of CAD, the physiological impact on the body, and the contributing determinants of CAD on Mississippi populations. Data on Mississippi populations were collected using the Center for Population Studies at the University of Mississippi. A multitude of individuals were evaluated when examining the causes and effects of CAD including men, women, …

Scientific Research Questions, Center For Urban Resilience

Module 09: Human-Animal Interactions

No abstract provided.

Ramipril Blunts Glycerol-Induced Acute Renal Failure In Rats Through Its Antiapoptosis, Anti-Inflammatory, Antioxidant, And Renin-Inhibiting Properties, Adeolu Alex Adedapo, Ehizogie Ruth Osaretin, Olufunke Olubunmi Falayi, Ademola Adetokunbo Oyagbemi, Blessing Seun Ogunpolu, Temidayo Olutayo Omobowale, Oluwafemi Omoniyi Oguntibeju, Momoh Audu Yakubu

Faculty Publications

Acute kidney injury (AKI) is a malady with a sudden onset resulting in buildup of waste matters in the body, but a specific cure hasn't been found as a lasting solution to AKI. In this study, ramipril was evaluated for its potential therapy in glycerol-induced AKI in rats. Twenty animals were divided into four groups of five animals each. Group I was the control while group II was given glycerol on day 8 only, groups III and IV were administered with pioglitazone (reference drug) and ramipril for seven days respectively and on day 8 received glycerol. On the ninth day, …

Loss Of Situational Awareness During Commercial Flight Over Colombian Mountains, Oscar Sarmiento Mejia

International Symposium on Aviation Psychology - 2021

No abstract provided.

Asynchronous Video Content For Human Anatomy & Physiology: In Coordinance With A Global Shift To Online Education, Hailey Phillips

2021 Spring Honors Capstone Projects - Archive

Working, short-term, and long-term memory are three of the essential brain functioning required to understand and master new material, whether online or in-person. My project is constructed to supplement Dr. Pollocks Anatomy & Physiology lecture for additional online reinforcement or independent study. The videos I have created strike the correct cognitive load balance for easy understanding while maintaining learning objectives. Videos were created via OneNote and additional effects were edited with Adobe Premiere Pro. The narration is recorded separately on a H2n Handy recorder and edited in audacity. The goal is to captivate and educate the viewer on the three …

The Benefits Of Activity-Based Learning Tools For Human Physiology And Anatomy Students In An Online Environment, Celine Pham

2021 Spring Honors Capstone Projects - Archive

With the transition to virtual learning, some students are finding difficulty in adapting to the online environment where there is a lack of face-to-face interactions and physical infrastructure. Therefore, alternative strategies need to be implemented for students to gain the most value out of their online education. To better enrich the learning experience, I created educational activity booklets, a type of teaching-learning strategy, for students taking courses in human anatomy and physiology. These booklets contain visual aids, crossword puzzles, flow charts, questions, and other active-learning tools to reinforce lecture material. This project is divided into 13 booklets, with each encompassing …

Evaluating The Impact Of Educational Videos On Higher Level Education: A Creative Research Approach, Veronica Camacho

2021 Spring Honors Capstone Projects - Archive

With increasing technological advancements, online resources such as educational videos have become an essential study tool for college students. Educational videos deliver information in the form of visual representations, animations and text which is organized in a condensed and organized manner. In this creative research project, two educational videos were created for a Human Physiology course at the University of Texas at Arlington. One video was over systemic and pulmonary gas transport/exchange and the other was over hemodynamics. The program, “Procreate,” was utilized to create the illustrations and “Explain Everything Whiteboard” was used for screen casting. This research paper evaluates …

The Hypothalamic-Pituitary-Somatotropic And Hypothalamic-Pituitary-Gonadal Axes Educational Videos, Josphin Mouris

2021 Spring Honors Capstone Projects - Archive

The endocrine system is essential for it controls metabolism, reproduction, mood, growth, development, and many more functions of the body. Yet due to its vast functions it can be difficult to grasp and because most of the activities of the system are not seen, it can be difficult to visualize. To mitigate the difficulty of learning the endocrine system, information was collected from the Human Physiology course PowerPoints as well as various textbooks and lectures to create visually engaging educational videos for students. Specifically, two videos were created using iMovie and PowerPoint to cover a brief overview of the endocrine …

Creating Educational Videos Of The Physiology Behind The Human Reproductive System, Autumn Morgan

2021 Spring Honors Capstone Projects - Archive

This project was designed to provide an optimal learning tool for future students in Human Physiology and Anatomy & Physiology by creating a visual representation of physiological processes. The task was to create two educational videos detailing the processes that take place within the human reproductive system. One video would be dedicated to the female reproductive system and the other would cover the male reproductive system. To pursue this project, the exact details to include in this video had to be discussed and outlined to create a script for the audio recording. Once the script was created and approved, a …

Psychological Aspects In Pilot Training: Cognition And Human Factors, Shagun Gupta

International Symposium on Aviation Psychology - 2021

Introduction-International Civil Aviation Organization’s (ICAO) SHELL model was designed to study and investigate the way the pilot interacted with the various dimensions of the model. Aim-The present study aimed to explore psychological aspects while flying using the dimensions of ICAO’s SHELL model of aviation. Methods-The study followed the qualitative research paradigm. The sample consisted of 9 (Males =4, Female =5) student trainee pilots in the age range of 18 – 21 years. They were subjected to in-depth interviews which lasted for around 30 minutes. The data were analyzed using the thematic network of analysis. Results-The results show that in the …

Assessing The Role Of Chronic Arsenite Exposure In Disrupting The Egfr Signaling Axis., Christine Kim

Electronic Theses and Dissertations

Chronic arsenic exposure is a risk factor for the development of pulmonary diseases, including lung cancer, but the exact mechanism is not yet fully understood. Many previous studies have relied on acute arsenic exposure (i.e. 1-10 uM arsenic for 24 hours) to study arsenic toxicological effects. However, acute exposure does not reflect the levels or duration of arsenic associated with environmental exposure, or drinking of contaminated well water. This dissertation differentiates the effects of acute versus chronic arsenic exposures on the EGFR signaling axis and suggests possible mechanisms for chronic arsenic-induced pulmonary diseases. The EGFR is a receptor tyrosine kinase …

Assessing The Validity And Reliability Of Several Heart Rate Monitors In Wearable Technology While Mountain Biking, Bryson Carrier

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study sought to assess the validity and reliability of several heart rate (HR) monitors during mountain biking (MTB), compared to the Polar H7® HR monitor, used as the criterion device. Methods: A total of 20 participants completed two MTB trials wearing 6 HR monitors (1 criterion, 5 test devices). HR was recorded on a second-by-second basis for all devices analyzed. After data processing, validity measures were calculated, including 1. Error analysis: mean absolute percentage errors (MAPE), mean absolute error (MAE), and mean error (ME), and 2. Correlation analysis: Lin’s concordance correlation coefficient (CCC) and Pearson’s correlation coefficient ®. Validity …

Virtual Screening For Potential New Chemotherapeutic Agents For The Gpr119 Receptor, A Target For Type Ii Diabetes, Jennifer Lizeth Bravo

Theses and Dissertations

Three frames from a molecular dynamics simulation run of a GPR119 receptor homology model were used for this study. The homology model was validated by virtually screening 76 known GPR119 receptor. 85% of these agonists bound to the receptor. Following the validation, 21,000 molecules were selected for the virtual screening study. 862 ligands came from the GPCR Selleckchem/Prestwick library, 42 compounds from the Prestwick Phytochemical library, 20,000 compounds from the ZINC library, plus four molecules from the literature. All ligands were built, geometry-optimized, and docked in the GPR119 models using a protocol combining High Throughput Virtual Screening, Standard Precision, and …

Reaction Pathways Initiated By One-Electron Oxidation Of Guanine: Reaction Pathways Leading To Stable End Products, Zach Cutright

Undergraduate Honors Theses

8-hydroxyguanine (8-oxoG) is one of the most important products resulting from the oxidation of guanine in DNA. 8-oxoG is known as a biomarker of oxidative stress such as lung cancer. 2,5-diamino-4H-imidazol-4-one (Iz) and its hydrolysis product 2,2-diamino-4-[(2-deoxy-β-D-erythro-pentofuranosyl)-amino]-2,5-dihydrooxazol-5-one (Oz) are also important products of oxidation of guanine in DNA. Recently, novel types of dimer intermediates related to 8-oxoG and Iz have been identified in our research lab. Using high performance liquid chromatography (HPLC), LC-MS, and NMR coupled with educated hypotheses, it is possible to identify the products, X1 and X2, resulting from the oxidation of guanine and decipher the mechanisms leading …

Leptin Activation Of Metabolically-Related Hypothalamic Neurons, Kailee Hixon

Undergraduate Honors Theses

Obesity is often associated with multiple other clinical conditions, including hypertension and cardiovascular disease. Currently, more than one-third of the world’s population is classified as obese. Leptin is a neuropeptide that is released from adipose cells and is responsible for reducing appetite and increasing metabolism. Leptin also has a role in the activation of cardiovascular and metabolic pre-sympathetic neurons and has been reported to increase blood pressure and heart rate. Thus, understanding the activation of the autonomic nervous system by leptin has implications in the development and safety of drugs to avoid activation of cardiovascular pre-sympathetic neurons. This is important …

Augmenting The Site Analysis Phase Of The Design Process Using Virtual Reality And Drones, Brandon Blauer

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Virtual reality (VR) is a tool that has been utilized by designers for decades now. In most cases, VR has been utilized in the latter part of the design process. More specifically, VR has been used most commonly towards the design review phase of the design process where people are often looking for a final design suggestion. With regards to the design review phase, there have been many reports discussing the effectiveness of VR. However, there has been little to no research regarding the use of VR in the site analysis phase of the design process.

This thesis develops a …

Impact Of Chronic Exposure Of Selected Azo Dyes On The Model Organism Caenorhabditis Elegans, Anson North

Dissertations (2016-Present)

Azo dyes are dyes used to color textiles, paper, leather, plastics, foods, cosmetics, pharmaceuticals, brewed beverages, tattoo inks, printing inks, and more. They account for over 50% of all commercially used dyes produced annually and identified by aromatic rings connected by nitrogen-nitrogen double bonds (N=N). Azo dyes yield colorless aromatic amines and become potentially carcinogenic after biotransformation. Lipid-soluble azo dyes are the most toxic and some are banned for food usage, yet still detected at low concentrations in palm oils, chili powders, eggs, and other food products.

The nematode Caenorhabditis elegans (C. elegans) has been used in many environmental studies …