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2021

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Articles 76921 - 76950 of 77026

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Cardiopulmonary Exercise Testing And Cardiopulmonary Morbidity In Patients Undergoing Major Head And Neck Surgery, B. B. Lalabekyan, N. Tetlow, R. Moonesinghe, D. Martin, E. Burdett, J. Otto, D. Wyndham, E. Bettini, N. Kalavrezos, R. C.M. Stephens Jan 2021

Cardiopulmonary Exercise Testing And Cardiopulmonary Morbidity In Patients Undergoing Major Head And Neck Surgery, B. B. Lalabekyan, N. Tetlow, R. Moonesinghe, D. Martin, E. Burdett, J. Otto, D. Wyndham, E. Bettini, N. Kalavrezos, R. C.M. Stephens

Peninsula Medical School

No abstract provided.


Editorial: Can Quantitative Fibrosis Assessment Be Used To Enhance Prediction Of Outcomes In Patients With Alcohol-Related Liver Disease?, Prebashan Moodley, Ashwin D. Dhanda Jan 2021

Editorial: Can Quantitative Fibrosis Assessment Be Used To Enhance Prediction Of Outcomes In Patients With Alcohol-Related Liver Disease?, Prebashan Moodley, Ashwin D. Dhanda

Peninsula Medical School

No abstract provided.


Effects Of Perioperative Oxygen Concentration On Oxidative Stress In Adult Surgical Patients: A Systematic Review, Alexander H. Oldman, Daniel S. Martin, Martin Feelisch, Michael P.W. Grocott, Andrew F. Cumpstey Jan 2021

Effects Of Perioperative Oxygen Concentration On Oxidative Stress In Adult Surgical Patients: A Systematic Review, Alexander H. Oldman, Daniel S. Martin, Martin Feelisch, Michael P.W. Grocott, Andrew F. Cumpstey

Peninsula Medical School

No abstract provided.


Assessment Of Hepatic Steatosis By Controlled Attenuation Parameter Using The M And Xl Probes: An Individual Patient Data Meta-Analysis, David Petroff, Valentin Blank, Philip N. Newsome, Shalimar, Cosmin Sebastian Voican, Maja Thiele, Lédinghen V De, Stephan Baumeler, Wah Kheong Chan, Gabriel Perlemuter, Ana Carolina Cardoso, Sandeep Aggarwal, Magali Sasso, Peter J. Eddowes, Michael Allison, Emmanuel Tsochatzis, Quentin M. Anstee, David Sheridan, Jeremy F. Cobbold, Sylvie Naveau, Monica Lupsor-Platon, Sebastian Mueller, Aleksander Krag, Marie Irles-Depe, David Semela, Gl-H Wong, Vw-S Wong, Cristiane A. Villela-Nogueira, Harshit Garg, Harshit Garg, Johannes Wiegand, Thomas Karlas Jan 2021

Assessment Of Hepatic Steatosis By Controlled Attenuation Parameter Using The M And Xl Probes: An Individual Patient Data Meta-Analysis, David Petroff, Valentin Blank, Philip N. Newsome, Shalimar, Cosmin Sebastian Voican, Maja Thiele, Lédinghen V De, Stephan Baumeler, Wah Kheong Chan, Gabriel Perlemuter, Ana Carolina Cardoso, Sandeep Aggarwal, Magali Sasso, Peter J. Eddowes, Michael Allison, Emmanuel Tsochatzis, Quentin M. Anstee, David Sheridan, Jeremy F. Cobbold, Sylvie Naveau, Monica Lupsor-Platon, Sebastian Mueller, Aleksander Krag, Marie Irles-Depe, David Semela, Gl-H Wong, Vw-S Wong, Cristiane A. Villela-Nogueira, Harshit Garg, Harshit Garg, Johannes Wiegand, Thomas Karlas

Peninsula Medical School

No abstract provided.


Evaluation Of A Primary Care-Based Collaborative Care Model (Partners2) For People With Diagnoses Of Schizophrenia, Bipolar, Or Other Psychoses: Study Protocol For A Cluster Randomised Controlled Trial, Humera Plappert, Charley Hobson-Merrett, Bliss Gibbons, Elina Baker, Sheridan Bevan, Michael Clark, Siobhan Creanor, Linda Davies, Rebecca Denyer, Julia Frost, Linda Gask, John Gibson, Laura Gill, Ruth Gwernan-Jones, Pollyanna Hardy, Joanne Hosking, Peter Huxley, Alison Jeffrey, Benjamin Jones, Steven Marwaha, Vanessa Pinold, Claire Planner, Tim Rawcliffe, Siobhan Reilly, Debra Richards, Lynsey Williams, Max Birchwood, Richard Byng Jan 2021

Evaluation Of A Primary Care-Based Collaborative Care Model (Partners2) For People With Diagnoses Of Schizophrenia, Bipolar, Or Other Psychoses: Study Protocol For A Cluster Randomised Controlled Trial, Humera Plappert, Charley Hobson-Merrett, Bliss Gibbons, Elina Baker, Sheridan Bevan, Michael Clark, Siobhan Creanor, Linda Davies, Rebecca Denyer, Julia Frost, Linda Gask, John Gibson, Laura Gill, Ruth Gwernan-Jones, Pollyanna Hardy, Joanne Hosking, Peter Huxley, Alison Jeffrey, Benjamin Jones, Steven Marwaha, Vanessa Pinold, Claire Planner, Tim Rawcliffe, Siobhan Reilly, Debra Richards, Lynsey Williams, Max Birchwood, Richard Byng

Peninsula Medical School

BackgroundCurrent NHS policy encourages an integrated approach to provision of mental and physical care for individuals with long term mental health problems. The ‘PARTNERS2’ complex intervention is designed to support individuals with psychosis in a primary care setting.AimThe trial will evaluate the clinical and cost-effectiveness of the PARTNERS2 intervention.Design & settingThis is a cluster randomised controlled superiority trial comparing collaborative care (PARTNERS2) with usual care, with an internal pilot to assess feasibility. The setting will be primary care within four trial recruitment areas: Birmingham & Solihull, Cornwall, Plymouth, and Somerset. GP practices are randomised 1:1 to either (a) the PARTNERS2 …


A Feasibility Randomised Controlled Trial Of Targeted Oxygen Therapy In Mechanically Ventilated Critically Ill Patients, Daniel S. Martin, Margaret Mcneil, Chris Brew-Graves, Helder Filipe, Ronan O’Driscoll, Jia Liu Stevens, Rachel Burnish, Andrew F. Cumpstey, Norman R. Williams, Michael G. Mythen, Michael P.W. Grocott Jan 2021

A Feasibility Randomised Controlled Trial Of Targeted Oxygen Therapy In Mechanically Ventilated Critically Ill Patients, Daniel S. Martin, Margaret Mcneil, Chris Brew-Graves, Helder Filipe, Ronan O’Driscoll, Jia Liu Stevens, Rachel Burnish, Andrew F. Cumpstey, Norman R. Williams, Michael G. Mythen, Michael P.W. Grocott

Peninsula Medical School

Background Despite oxygen being the commonest drug administered to critically ill patients we do not know which oxygen saturation (SpO2) target results in optimal survival outcomes in those receiving mechanical ventilation. We therefore conducted a feasibility randomised controlled trial in the United Kingdom (UK) to assess whether it would be possible to host a larger national multi-centre trial to evaluate oxygenation targets in mechanically ventilated patients. Methods We set out to recruit 60 participants across two sites into a trial in which they were randomised to receive conservative oxygenation (SpO2 88–92%) or usual care (control – SpO2 ≥96%). The primary …


Fertility And Digital Technology: Narratives Of Using Smartphone App ‘Natural Cycles’ While Trying To Conceive, Pippa Grenfell, Nerissa Tilouche, Jill Shawe, Rebecca S. French Jan 2021

Fertility And Digital Technology: Narratives Of Using Smartphone App ‘Natural Cycles’ While Trying To Conceive, Pippa Grenfell, Nerissa Tilouche, Jill Shawe, Rebecca S. French

School of Nursing and Midwifery

No abstract provided.


Physiological Responses During Ascent To High Altitude And The Incidence Of Acute Mountain Sickness, Alexandra B. Cobb, Denny Z.H. Levett, K Mitchell, Wynne Aveling, D Hurlbut, E Gilbert‐Kawai, Philip J. Hennis, Mg Mythen, Michael P.W. Grocott, Ds Martin, V. Ahuja, G Aref‐Adib, R. Burnham, A. Chisholm, K. Clarke, D Coates, M Coates, D. Cook, M. Cox, S. Dhillon, C. Dougall, P. Doyle, P. Duncan, M. Edsell, L. Edwards, L. Evans, P. Gardiner, Michael P.W. Grocott, P. Gunning, J. Harrington, J. Harrington, J. Harvey, C. Holloway, D. Howard, D Hurlbut, C. Imray, C. Ince, Der Kaaij J Van, M. Khosravi, N. Kolfschoten, Denny Z.H. Levett, H Luery, A. Luks, D Martin, R. Mcmorrow, P. Meale, K Mitchell, H. Montgomery, G Morgan, J Morgan, A. Murray, M Mythen, S Newman, V O’Dwyer, J Pate, T Plant, V Pun, P Richards, A Richardson, G Rodway, J Simpson, C Stroud, M Stroud, J Stygal, B Symons, P Szawarski, Tulleken A Van, Tulleken C Van, A Vercueil, L Wandrag, M Wilson, J Windsor, B Basnyat, K. Clarke, T Hornbein, J Milledge, J West, S Abraham, T Adams, W Anseeuw, R Astin, B Basnyat, O Burdall, J Carroll, Alexandra B. Cobb, J Coppel, O Couppis, J Court, A Cumpstey, T Davies, S. Dhillon, N Diamond, C. Dougall, T Geliot, E Gilbert‐Kawai, G Gilbert‐Kawai, E Gnaiger, M Grocott, C Haldane, P Hennis, J Horscroft, D Howard, S Jack, B Jarvis, W Jenner, G Jones, J Van Der Kaaij, J Kenth, A Kotwica, R Kumar Bc, J Lacey, V Laner, D Levett, D Martin, P Meale, K Mitchell, Z Mahomed, J Moonie, A Murray, M Mythen, P Mythen, K O’Brien, I Ruggles‐Brice, K Salmon, A Sheperdigian, T Smedley, B Symons, C Tomlinson, A Vercueil, L Wandrag, S Ward, A Wight, C Wilkinson, S Wythe, M Feelisch, E Gilbert‐Kawai, M Grocott, M Hanson, D Levett, D Martin, K Mitchell, H Montgomery, R Moon, A Murray, M Mythen, M Peters Jan 2021

Physiological Responses During Ascent To High Altitude And The Incidence Of Acute Mountain Sickness, Alexandra B. Cobb, Denny Z.H. Levett, K Mitchell, Wynne Aveling, D Hurlbut, E Gilbert‐Kawai, Philip J. Hennis, Mg Mythen, Michael P.W. Grocott, Ds Martin, V. Ahuja, G Aref‐Adib, R. Burnham, A. Chisholm, K. Clarke, D Coates, M Coates, D. Cook, M. Cox, S. Dhillon, C. Dougall, P. Doyle, P. Duncan, M. Edsell, L. Edwards, L. Evans, P. Gardiner, Michael P.W. Grocott, P. Gunning, J. Harrington, J. Harrington, J. Harvey, C. Holloway, D. Howard, D Hurlbut, C. Imray, C. Ince, Der Kaaij J Van, M. Khosravi, N. Kolfschoten, Denny Z.H. Levett, H Luery, A. Luks, D Martin, R. Mcmorrow, P. Meale, K Mitchell, H. Montgomery, G Morgan, J Morgan, A. Murray, M Mythen, S Newman, V O’Dwyer, J Pate, T Plant, V Pun, P Richards, A Richardson, G Rodway, J Simpson, C Stroud, M Stroud, J Stygal, B Symons, P Szawarski, Tulleken A Van, Tulleken C Van, A Vercueil, L Wandrag, M Wilson, J Windsor, B Basnyat, K. Clarke, T Hornbein, J Milledge, J West, S Abraham, T Adams, W Anseeuw, R Astin, B Basnyat, O Burdall, J Carroll, Alexandra B. Cobb, J Coppel, O Couppis, J Court, A Cumpstey, T Davies, S. Dhillon, N Diamond, C. Dougall, T Geliot, E Gilbert‐Kawai, G Gilbert‐Kawai, E Gnaiger, M Grocott, C Haldane, P Hennis, J Horscroft, D Howard, S Jack, B Jarvis, W Jenner, G Jones, J Van Der Kaaij, J Kenth, A Kotwica, R Kumar Bc, J Lacey, V Laner, D Levett, D Martin, P Meale, K Mitchell, Z Mahomed, J Moonie, A Murray, M Mythen, P Mythen, K O’Brien, I Ruggles‐Brice, K Salmon, A Sheperdigian, T Smedley, B Symons, C Tomlinson, A Vercueil, L Wandrag, S Ward, A Wight, C Wilkinson, S Wythe, M Feelisch, E Gilbert‐Kawai, M Grocott, M Hanson, D Levett, D Martin, K Mitchell, H Montgomery, R Moon, A Murray, M Mythen, M Peters

Peninsula Medical School

No abstract provided.


Clarifying Realist Analytic And Interdisciplinary Consensus Processes In A Complex Health Intervention: A Worked Example Of Judgemental Rationality In Action, Sarah Rybczynska-Bunt, Lauren Weston, Richard Byng, Alex Stirzaker, Charlotte Lennox, Mark Pearson, Sarah Brand, Mike Maguire, Graham Durcan, Jonathan Graham, Sarah Leonard, Jenny Shaw, Tim Kirkpatrick, Christabel Owens, Cath Quinn Jan 2021

Clarifying Realist Analytic And Interdisciplinary Consensus Processes In A Complex Health Intervention: A Worked Example Of Judgemental Rationality In Action, Sarah Rybczynska-Bunt, Lauren Weston, Richard Byng, Alex Stirzaker, Charlotte Lennox, Mark Pearson, Sarah Brand, Mike Maguire, Graham Durcan, Jonathan Graham, Sarah Leonard, Jenny Shaw, Tim Kirkpatrick, Christabel Owens, Cath Quinn

Peninsula Medical School

Judgemental rationality is infrequently referenced within discussions of Realist Evaluations. Judgemental rationality refers to researchers’ capacity to assess which, potential, meanings provide the most credible explanations. In evaluation work, rationale for analysis is provided, though rarely do we see how an evaluator made judgements between competing theories, and which theories were discarded and why. We provide a worked example of the application of judgemental rationality. The Engager intervention offered support to prison leavers with common mental health problems. The data for 24, purposively sampled, participants from the intervention arm of the trial were integrated. Bhaskar’s DREIC, a five-step analytical procedure, …


Editorial: Extending The Evidence For If And How Physical Activity Can Support Positive Changes Among Substance Users, Adrian H. Taylor, Tom P. Thompson, Ana Abrantes, Mats Hallgren Jan 2021

Editorial: Extending The Evidence For If And How Physical Activity Can Support Positive Changes Among Substance Users, Adrian H. Taylor, Tom P. Thompson, Ana Abrantes, Mats Hallgren

Peninsula Medical School

No abstract provided.


Mental Health And Physical Activity, Yoga And Other Holistic Movement Practices (Hmps): A Position Statement, Adrian Taylor, Ana Abrantes, Mats Hallgren, Matthew Herring, Caterina Pesce, Simon Rosenbaum, Megan Teychenne Jan 2021

Mental Health And Physical Activity, Yoga And Other Holistic Movement Practices (Hmps): A Position Statement, Adrian Taylor, Ana Abrantes, Mats Hallgren, Matthew Herring, Caterina Pesce, Simon Rosenbaum, Megan Teychenne

Peninsula Medical School

No abstract provided.


Preliminary Development Of A Questionnaire To Measure The Extra-Pulmonary Symptoms Of Severe Asthma, Felice G De, Michael E. Hyland, Joseph W. Lanario, Yuri Antonacci, Rupert C. Jones, Matthew Masoli Jan 2021

Preliminary Development Of A Questionnaire To Measure The Extra-Pulmonary Symptoms Of Severe Asthma, Felice G De, Michael E. Hyland, Joseph W. Lanario, Yuri Antonacci, Rupert C. Jones, Matthew Masoli

School of Psychology

Abstract Background Research into the effects of asthma treatments on the extra-pulmonary symptoms of severe asthma is limited by the absence of a suitable questionnaire. The aim was to create a questionnaire suitable for intervention studies by selecting symptoms that are statistically associated with asthma pathology and therefore may improve when pathology is reduced. Methods Patients attending a specialist asthma clinic completed the 65-item General Symptom Questionnaire (GSQ-65), a questionnaire validated for assessing symptoms of people with multiple medically unexplained symptoms. Lung function (FEV1%) and cumulative oral corticosteroids (OCS) calculated from maintenance dose plus exacerbations were obtained from clinic records. …


The Second World Ocean Assessment Volume 1, Jason Hall-Spencer, Louise Firth Jan 2021

The Second World Ocean Assessment Volume 1, Jason Hall-Spencer, Louise Firth

School of Biological and Marine Sciences

In its resolutions 57/141 and 58/240, the General Assembly decided to establish a regular processunder the United Nations for global reporting and assessment of the state of the marineenvironment, including socioeconomic aspects, both current and foreseeable, building on existingregional assessments. In its resolution 71/257, the Assembly recalled that the scope of thefirst cycle of the Regular Process focused on establishing a baseline and decided that the scopeof the second cycle would extend to evaluating trends and identifying gaps. The programme ofwork for the period 2017–2020 of the second cycle of the Regular Process includes the preparationby the Group of Experts …


Julian Stander, Katerina Tzioli And Mario Cortina Borja: 200 Years Of Greek Independence… And Pms, J Stander, K Tzioli, Borja M Cortina Jan 2021

Julian Stander, Katerina Tzioli And Mario Cortina Borja: 200 Years Of Greek Independence… And Pms, J Stander, K Tzioli, Borja M Cortina

School of Engineering, Computing and Mathematics

No abstract provided.


The Relationship Between Gestational Weight Gain, Maternal Upper-Body Subcutaneous Fat Changes And Infant Birth Size: A Pilot Observational Study Amongst Women With Obesity, Kathy M. Redfern, Heidi J. Hollands, Joanne Hosking, C. Ross Welch, Jonathan H. Pinkney, Gail A. Rees Jan 2021

The Relationship Between Gestational Weight Gain, Maternal Upper-Body Subcutaneous Fat Changes And Infant Birth Size: A Pilot Observational Study Amongst Women With Obesity, Kathy M. Redfern, Heidi J. Hollands, Joanne Hosking, C. Ross Welch, Jonathan H. Pinkney, Gail A. Rees

School of Biomedical Sciences

No abstract provided.


What Do We Know About Business Strategy And Environmental Research? Insights From Business Strategy And The Environment, S Kumar, R Sureka, Wm Lim, Mangla S Kumar, N Goyal Jan 2021

What Do We Know About Business Strategy And Environmental Research? Insights From Business Strategy And The Environment, S Kumar, R Sureka, Wm Lim, Mangla S Kumar, N Goyal

Plymouth Business School

No abstract provided.


Effect Of Methionine Feeding On Oxidative Stress, Intracellular Calcium And Contractility In Cardiomyocytes Isolated From Male And Female Rats, Shatha A. Demerchi, Nicola King, James R. Mcfarlane, Pierre D.J. Moens Jan 2021

Effect Of Methionine Feeding On Oxidative Stress, Intracellular Calcium And Contractility In Cardiomyocytes Isolated From Male And Female Rats, Shatha A. Demerchi, Nicola King, James R. Mcfarlane, Pierre D.J. Moens

School of Biomedical Sciences

Homocysteine (Hcy) is a breakdown product of methionine metabolism. The risk of cardiovascular disease (CVD) correlates with an increase in plasma Hcy levels. The aim of this study was to investigate whether 1% methionine supplementation of adult rats altered intracellular reactive oxygen species (ROS) generation, intracellular Ca2+ content, and contractile activity in freshly isolated cardiomyocytes. This was measured under normal conditions and during oxidative stress in freshly isolated cardiomyocytes. Single rat cardiomyocytes from both sexes were isolated by enzymatic and mechanical dispersion techniques. Fluorescence microscopy was used to measure ROS production and intracellular Ca2+ concentration. Cell contraction was measured using …


Htk Versus Multidose Cardioplegias For Myocardial Protection In Adult Cardiac Surgery: A Meta‐Analysis, Alexander C. Reynolds, Sanjay Asopa, Amit Modi, Nicola King Jan 2021

Htk Versus Multidose Cardioplegias For Myocardial Protection In Adult Cardiac Surgery: A Meta‐Analysis, Alexander C. Reynolds, Sanjay Asopa, Amit Modi, Nicola King

School of Biomedical Sciences

No abstract provided.


An Online Museum Of Stories: Literary Travel Writing For Cultural Tourism Development, C Mansfield, J Potočnik Topler Jan 2021

An Online Museum Of Stories: Literary Travel Writing For Cultural Tourism Development, C Mansfield, J Potočnik Topler

Plymouth Business School

With rising tourism interest in cultural heritage, destination management organisations, museums and other cultural institutions are seeking methods of unlocking the intangible cultural heritage of local residents and sharing that before it is lost. This is specific knowledge of the uses and practices of disappearing spaces in towns, of plants and their uses as foodstuffs, and in clothing and of work practices that were more in-tune with local, sustainable production. This contribution outlines new methods for building the ethnographic museum as a museum of stories, and proposes a model that explores narrative through literary travel writing for a new public.


Ecotoxicology Of Active Ingredients In Changing Marine Environments, Cameron Hird Jan 2021

Ecotoxicology Of Active Ingredients In Changing Marine Environments, Cameron Hird

School of Biomedical Sciences

Active ingredients (AIs), including pesticides and pharmaceuticals, are designed to have a specific mode-of-action (MoA) in target organisms. Despite this, there is substantial evidence of their occurrence in marine environments having the potential to impact non-target species with effects both as a result of, and independent from, their MoA. Furthermore, due to a large proportion of AIs being readily ionisable, there is growing evidence that their uptake and effects are sensitive to environmental parameters such as pH, which can be driven by changes in pCO2,both in natural cycles and as a consequence of anthropogenic activities.In this thesis I investigate the …


In-Vivo Wound Healing Activity Of A Novel Composite Sponge Loaded With Mucilage And Lipoidal Matter Of Hibiscus Species, Dalia Attia, Riham Bakr, Reham Amer, Mai Abdelhafez, Asmaa Al-Mokaddem, Abd El-Nasser El-Gendy, Ahlam El-Fishawy, Marwa Fayed, Sameh Gad Jan 2021

In-Vivo Wound Healing Activity Of A Novel Composite Sponge Loaded With Mucilage And Lipoidal Matter Of Hibiscus Species, Dalia Attia, Riham Bakr, Reham Amer, Mai Abdelhafez, Asmaa Al-Mokaddem, Abd El-Nasser El-Gendy, Ahlam El-Fishawy, Marwa Fayed, Sameh Gad

Pharmacy

Many researches have been undergone to hasten the natural wound healing process. In this study, several Hibiscus species (leaves) were extracted with petroleum ether, methanol, and their mucilage was separated. All the tested species extracts were assessed for their viability percentage using the water-soluble tetrazolium. H.syriacus was the plant of choice to be incorporated in a new drug delivery system and evaluated for its wound healing activity. H.syriacus petroleum ether extract (PEE) showed a high percentage of palmitic and oleic acids while its mucilage demonstrated high glucosamine and galacturonic acid. It was selected to be formulated and pharmaceutically evaluated into …


Fabrication And Characterization Of Agarwood Extract-Loaded Nanocapsules And Evaluation Of Their Toxicity And Anti-Inflammatory Activity On Raw 264.7 Cells And In Zebrafish Embryos, Eman Ramadan, Manar A. Eissa, Noha Badawi Jan 2021

Fabrication And Characterization Of Agarwood Extract-Loaded Nanocapsules And Evaluation Of Their Toxicity And Anti-Inflammatory Activity On Raw 264.7 Cells And In Zebrafish Embryos, Eman Ramadan, Manar A. Eissa, Noha Badawi

Pharmacy

Aquilaria malaccensis has been traditionally used to treat several medical disorders including inflammation. However, the traditional claims of this plant as an anti-inflammatory agent has not been substantially evaluated using modern scientific techniques. The main objective of this study was to evaluate the anti-inflammatory effect of Aquilaria malacensis leaf extract (ALEX-M) and potentiate its activity through nano-encapsulation. The extract-loaded nanocapsules were fabricated using water-in-oil-in-water (w/o/w) emulsion method and characterized via multiple techniques including DLS, TEM, FTIR, and TGA. The toxicity and the anti-inflammatory activity of ALEX-M and the extract-loaded nanocapsules (ALEX-M-PNCs) were evaluated in-vitro on RAW 264.7 macrophages …


Novel Mechanistic Insights Towards The Repositioning Of Alogliptin In Parkinson's Disease, Eman Ramadan, Marwa M. Safar Jan 2021

Novel Mechanistic Insights Towards The Repositioning Of Alogliptin In Parkinson's Disease, Eman Ramadan, Marwa M. Safar

Pharmacy

Parkinson's disease (PD) is a progressive neurodegenerative disease that impairs people's lives tremendously. The development of innovative treatment modalities for PD is a significant unmet medical need. The critical function of glucagon-like peptide-1 (GLP-1) in neurodegenerative diseases has raised impetus in investigating the repositioning of a dipeptidyl peptidase IV inhibitor, alogliptin (ALO), as an effective treatment for PD. As a result, the focus of this research was to assess the effect of ALO in a rat rotenone (ROT) model of PD. For 21 days, ROT (1.5 mg/kg) was delivered subcutaneously every other day. ALO (30 mg/kg/day), delivered by gavage for …


Targeting Ros-Dependent Akt/Gsk-3Β/Nf-Κb And Dj-1/Nrf2 Pathways By Dapagliflozin Attenuates Neuronal Injury And Motor Dysfunction In Rotenone-Induced Parkinson’S Disease Rat Model, Marwa Safar Jan 2021

Targeting Ros-Dependent Akt/Gsk-3Β/Nf-Κb And Dj-1/Nrf2 Pathways By Dapagliflozin Attenuates Neuronal Injury And Motor Dysfunction In Rotenone-Induced Parkinson’S Disease Rat Model, Marwa Safar

Pharmacy

No abstract provided.


Chloroquine Ameliorates Bone Loss Induced By D-Galactose In Male Rats Via Inhibition Of Erk Associated Osteoclastogenesis And Antioxidant Effect., Marwa Safar Jan 2021

Chloroquine Ameliorates Bone Loss Induced By D-Galactose In Male Rats Via Inhibition Of Erk Associated Osteoclastogenesis And Antioxidant Effect., Marwa Safar

Pharmacy

No abstract provided.


Rutin Ameliorates Hepatic Fibrosis Via Targeting Hepatic Stellate Cells’ Activation, Proliferation And Apoptosis, Marwa Safar Jan 2021

Rutin Ameliorates Hepatic Fibrosis Via Targeting Hepatic Stellate Cells’ Activation, Proliferation And Apoptosis, Marwa Safar

Pharmacy

No abstract provided.


The Therapeutic Effects Of Epigallocatechin-3-Gallate And Rutin, Either Alone Or In Combination With Low-Dose Radiation, Against Testicular Injury Evoked By Nicotine In Rats., Marwa Safar Jan 2021

The Therapeutic Effects Of Epigallocatechin-3-Gallate And Rutin, Either Alone Or In Combination With Low-Dose Radiation, Against Testicular Injury Evoked By Nicotine In Rats., Marwa Safar

Pharmacy

No abstract provided.


Novel Mechanistic Insights Towards The Repositioning Of Alogliptin In Parkinson's Disease., Marwa Safar Jan 2021

Novel Mechanistic Insights Towards The Repositioning Of Alogliptin In Parkinson's Disease., Marwa Safar

Pharmacy

No abstract provided.


Radical Response: Effects Of Heat Stress-Induced Oxidative Stress On Lipid Metabolism In The Avian Liver, Nima K. Emami, Usuk Jung, Brynn Voy, Sami Dridi Jan 2021

Radical Response: Effects Of Heat Stress-Induced Oxidative Stress On Lipid Metabolism In The Avian Liver, Nima K. Emami, Usuk Jung, Brynn Voy, Sami Dridi

Poultry Science Faculty Publications and Presentations

Lipid metabolism in avian species places unique demands on the liver in comparison to most mammals. The avian liver synthesizes the vast majority of fatty acids that provide energy and support cell membrane synthesis throughout the bird. Egg production intensifies demands to the liver as hepatic lipids are needed to create the yolk. The enzymatic reactions that underlie de novo lipogenesis are energetically demanding and require a precise balance of vitamins and cofactors to proceed efficiently. External stressors such as overnutrition or nutrient deficiency can disrupt this balance and compromise the liver’s ability to support metabolic needs. Heat stress is …


Upstream Regulator Analysis Of Wooden Breast Myopathy Proteomics In Commercial Broilers And Comparison To Feed Efficiency Proteomics In Pedigree Male Broilers, Walter G. Bottje, Kentu R. Lassiter, Vivek A. Kuttappan, Nicholas J. Hudson, Casey M. Owens, Benham Abasht, Sami Dridi, Byungwhi C. Kong Jan 2021

Upstream Regulator Analysis Of Wooden Breast Myopathy Proteomics In Commercial Broilers And Comparison To Feed Efficiency Proteomics In Pedigree Male Broilers, Walter G. Bottje, Kentu R. Lassiter, Vivek A. Kuttappan, Nicholas J. Hudson, Casey M. Owens, Benham Abasht, Sami Dridi, Byungwhi C. Kong

Poultry Science Faculty Publications and Presentations

In an effort to understand the apparent trade-off between the continual push for growth performance and the recent emergence of muscle pathologies, shotgun proteomics was conducted on breast muscle obtained at similar to 8 weeks from commercial broilers with wooden breast (WB) myopathy and compared with that in pedigree male (PedM) broilers exhibiting high feed efficiency (FE). Comparison of the two proteomic datasets was facilitated using the overlay function of Ingenuity Pathway Analysis (IPA) (Qiagen, CA, USA). We focused on upstream regulator analysis and disease-function analysis that provides predictions of activation or inhibition of molecules based on (a) expression of …