Digital Commons Network^™

First Report Of A Multicenter Prospective Registry Of Cranioplasty In The United Kingdom And Ireland, Daniel M. Fountain, Jack Henry, Susan Honeyman, P O’Connor, Priya Sekhon, Rory J. Piper, Ellie Edlmann, Michael Martin, Gemma Whiting, Carole Turner, Harry Mee, Alexis J. Joannides, Angelos G. Kolias, Peter J. Hutchinson, Adam Williams, Ajay Sinha, Alex Leggate, Antonio Belli, Anuj Bahl, Catherine Mcmahon, Christos Tolias, Daniel Holsgrove, D O’Brien, Diederik Bulters, Edward St George, Giles Critchley, Greg James, Harith Akram, Jonathan Pollock, Manjunath Prasad

Peninsula Medical School

Abstract BACKGROUND There are many questions that remain unanswered regarding outcomes following cranioplasty including the timing of cranioplasty following craniectomy as well as the material used. OBJECTIVE To establish and evaluate 30-d outcomes for all cranial reconstruction procedures in the United Kingdom (UK) and Ireland through a prospective multicenter cohort study. METHODS Patients undergoing cranioplasty insertion or revision between June 1, 2019 and November 30, 2019 in 25 neurosurgical units were included. Data collected include demographics, craniectomy date and indication, cranioplasty material and date, and 30-d outcome. RESULTS In total, 313 operations were included, consisting of 255 new cranioplasty insertions …

Valproate Prescribing Practices For Women With Intellectual Disability Across Europe, Lance Watkins, Markus Reuber, Bhathika Perera, Ken Courtenay, Roger Banks, Emma Murphy, H Angus‐Leppan, Rohit Shankar

Peninsula Medical School

Abstract Background Valproate (VPA) is a known teratogen associated with greater risk of major congenital malformations and other neurodevelopmental sequelae than all other licensed antiepileptic medicines. To reduce the potential for VPA-related teratogenicity, the European Medicines Agency issued recommendations in 2018. Over two-thirds of women/girls with intellectual disability (ID) may have treatment-resistant epilepsy that could benefit from VPA treatment. Aims This investigation compared VPA prescribing practice for women/girls with ID between European countries, specifically evaluating the practice in the UK with that in other countries. Methods An expert working group with representation from key stake-holding organizations developed a survey for …

An International Genome-Wide Meta-Analysis Of Primary Biliary Cholangitis: Novel Risk Loci And Candidate Drugs, Heather J. Cordell, James J. Fryett, Kazuko Ueno, Rebecca Darlay, Yoshihiro Aiba, Yuki Hitomi, Minae Kawashima, Nao Nishida, Seik Soon Khor, Olivier Gervais, Yosuke Kawai, Masao Nagasaki, Katsushi Tokunaga, Ruqi Tang, Yongyong Shi, Zhiqiang Li, Brian D. Juran, Elizabeth J. Atkinson, Alessio Gerussi, Marco Carbone, Rosanna Asselta, Angela Cheung, Andrade M De, Aris Baras, Julie Horowitz, Manuel A.R. Ferreira, Dylan Sun, David E. Jones, Steven Flack, Steven Flack

Peninsula Medical School

No abstract provided.

Site-Level Variation In The Characteristics And Care Of Infants With Neonatal Opioid Withdrawal, Leslie W. Young, Zhuopei Hu, Robert D. Annett, Abhik Das, Janell F. Fuller, Rosemary D. Higgins, Barry M. Lester, Stephanie L. Merhar, Alan E. Simon, Songthip Ounpraseuth, P Brian Smith, Margaret M. Crawford, Andrew M. Atz, Lesley E. Cottrell, Adam J. Czynski, Sarah Newman, David A. Paul, Pablo J. Sánchez, Erin O. Semmens, M Cody Smith, Christine B. Turley, Bonny L. Whalen, Brenda B. Poindexter, Jessica N. Snowden, Lori A. Devlin, Eunice Kennedy Shriver National Institute Of Child Health And Human Development Neonatal Research Network And The Nih Environmental Influences On Child Health Outcomes (Echo) Program Institutional Development Awards States Pediatric Clinical Trials Network

Pediatrics Research and Scholarship

BACKGROUND AND OBJECTIVES: Variation in pediatric medical care is common and contributes to differences in patient outcomes. Site-to-site variation in the characteristics and care of infants with neonatal opioid withdrawal syndrome (NOWS) has yet to be quantified. Our objective was to describe site-to-site variation in maternal-infant characteristics, infant management, and outcomes for infants with NOWS.

METHODS: Cross-sectional study of 1377 infants born between July 1, 2016, and June 30, 2017, who were ≥36 weeks' gestation, with NOWS (evidence of opioid exposure and NOWS scoring within the first 120 hours of life) born at or transferred to 1 of 30 participating …

Medical Nutrition Therapy Access In Ckd: A Cross-Sectional Survey Of Patients And Providers, Elizabeth Yakes Jimenez, Kathryn Kelley, Marsha Schofield, Deborah Brommage, Alison Steiber, Jenica K. Abram, Holly Kramer

Pediatrics Research and Scholarship

RATIONALE & OBJECTIVE: Nutrition management can slow the progression of chronic kidney disease (CKD) and help manage complications of CKD, but few individuals with CKD receive medical nutrition therapy before initiating dialysis. This study aimed to identify knowledge, attitudes, experiences, and practices regarding medical nutrition therapy and barriers and facilitators to medical nutrition therapy access for individuals with CKD stages G1-G5 from the perspective of patients and providers.

STUDY DESIGN: Cross-sectional study composed of anonymous surveys.

SETTING & POPULATION: Adults with CKD stages G1-G5 and medical providers and registered dietitian nutritionists who regularly see patients with CKD stages G1-G5 were …

Capacity Building For A New Multicenter Network Within The Echo Idea States Pediatric Clinical Trials Network, Robert D. Annett, Scott Bickel, John C. Carlson, Kelly Cowan, Sara Cox, Mark J. Fisher, J Dean Jarvis, Alberta S. Kong, Jessica S. Kosut, Kurtis R. Kulbeth, Abbot Laptook, Pearl A. Mcelfish, Mary M. Mcnally, Lee M. Pachter, Barbara A. Pahud, Lee A. Pyles, Jennifer Shaw, Kari Simonsen, Jessica Snowden, Christine B. Turley, Andrew M. Atz

Pediatrics Research and Scholarship

No abstract provided.

Vacteens.Org: A Mobile Web App To Improve Hpv Vaccine Uptake, W Gill Woodall, Gregory Zimet, Alberta Kong, David Buller, Jeannyfer Reither, Lance Chilton, Valerie Myers, Randall Starling

Pediatrics Research and Scholarship

U.S. HPV vaccine uptake remains below the Healthy People 2030 goal of 80% series completion. Parental concerns and misinformation about the efficacy and safety of the Human Papillomavirus (HPV) vaccine remain, and may be addressed by digital interventions tailored to their concerns. Reported here are results from a small scale randomized trial testing a mobile web app for parents and their adolescent daughters (ages 11-14 years) encouraging HPV vaccination in New Mexico, an ethnically-diverse U.S. state.

Drug Repurposing For Targeting Cyclic Nucleotide Transporters In Acute Leukemias - A Missed Opportunity, Dominique R. Perez, Larry A. Sklar, Alexandre Chigaev, Ksenia Matlawska-Wasowska

Pediatrics Research and Scholarship

While current treatment regimens for acute leukemia can dramatically improve patient survival, there remains room for improvement. Due to its roles in cell differentiation, cell survival, and apoptotic signaling, modulation of the cyclic AMP (cAMP) pathway has provided a meaningful target in hematological malignancies. Several studies have demonstrated that gene expression profiles associated with increased pro-survival cAMP activity or downregulation of various pro-apoptotic factors associated with the cAMP pathway are apparent in acute leukemia patients. Previous work to increase leukemia cell intracellular cAMP focused on the use of cAMP analogs, stimulating cAMP production via transmembrane-associated adenylyl cyclases, or decreasing cAMP …

Metabolic Reprogramming And Cell Adhesion In Acute Leukemia Adaptation To The Cns Niche, Nitesh D. Sharma, Esra'a Keewan, Ksenia Matlawska-Wasowska

Pediatrics Research and Scholarship

Involvement of the Central Nervous System (CNS) in acute leukemia confers poor prognosis and lower overall survival. Existing CNS-directed therapies are associated with a significant risk of short- or long-term toxicities. Leukemic cells can metabolically adapt and survive in the microenvironment of the CNS. The supporting role of the CNS microenvironment in leukemia progression and dissemination has not received sufficient attention. Understanding the mechanism by which leukemic cells survive in the nutrient-poor and oxygen-deprived CNS microenvironment will lead to the development of more specific and less toxic therapies. Here, we review the current literature regarding the roles of metabolic reprogramming …

Placental Transfusion And Short-Term Outcomes Among Extremely Preterm Infants, Neha Kumbhat, Barry Eggleston, Alexis S Davis, Krisa P Van Meurs, Sara Bonamo Demauro, Elizabeth E Foglia, Satyanarayan Lakshminrusimha, Michele C Walsh, Kristi L Watterberg, Myra H Wyckoff, Abhik Das, Sara C Handley

Pediatrics Research and Scholarship

OBJECTIVE: To compare short-term outcomes after placental transfusion (delayed cord clamping (DCC) or umbilical cord milking (UCM)) versus immediate cord clamping among extremely preterm infants.

DESIGN: Retrospective study.

SETTING: The

PATIENTS: Infants born <29 >weeks' gestation in 2016 or 2017 without congenital anomalies who received active treatment after delivery.

INTERVENTION/EXPOSURE: DCC or UCM.

MAIN OUTCOME MEASURES: Primary outcomes: (1) composite of mortality or major morbidity by 36 weeks' postmenstrual age (PMA); (2) mortality by 36 weeks PMA and (3) composite of major morbidities by 36 weeks' PMA. Secondary composite outcomes: (1) any grade intraventricular haemorrhage or mortality by 36 weeks' PMA …