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2021

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Articles 76951 - 76980 of 77026

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The Remote Assessment Of Parkinsonism Supporting The Ongoing Development Of Interventions In Gaucher Disease, Abigail Louise Higgins, Marco Toffoli, Stephen Mullin, Chiao Yin Lee, Sofia Koletsi, Micol Avenali, Fabio Blandini, Anthony H.V. Schapira Jan 2021

The Remote Assessment Of Parkinsonism Supporting The Ongoing Development Of Interventions In Gaucher Disease, Abigail Louise Higgins, Marco Toffoli, Stephen Mullin, Chiao Yin Lee, Sofia Koletsi, Micol Avenali, Fabio Blandini, Anthony H.V. Schapira

Peninsula Medical School

Mutations in GBA which are causative of Gaucher disease in their biallelic form, are the most common genetic risk factor for Parkinson's disease (PD). The diagnosis of PD relies upon clinically defined motor features which appear after irreversible neurodegeneration. Prodromal symptoms of PD may provide a means to predict latent pathology, years before the onset of motor features. Previous work has reported prodromal features of PD in GBA mutation carriers, however this has been insufficiently sensitive to identify those that will develop PD. The Remote Assessment of Parkinsonism Supporting Ongoing Development of Interventions in Gaucher Disease (RAPSODI GD) study assesses …

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Galleria Mellonella Larvae Exhibit A Weight-Dependent Lethal Median Dose When Infected With Methicillin-Resistant Staphylococcus Aureus, Poppy J. Hesketh-Best, Michelle V. Mouritzen, Kayleigh Shandley-Edwards, Richard A. Billington, Mathew Upton Jan 2021

Galleria Mellonella Larvae Exhibit A Weight-Dependent Lethal Median Dose When Infected With Methicillin-Resistant Staphylococcus Aureus, Poppy J. Hesketh-Best, Michelle V. Mouritzen, Kayleigh Shandley-Edwards, Richard A. Billington, Mathew Upton

School of Biological and Marine Sciences

ABSTRACT Galleria mellonella is a recognised model to study antimicrobial efficacy; however, standardisation across the scientific field and investigations of methodological components are needed. Here, we investigate the impact of weight on mortality following infection with Methicillin-resistant Staphylococcus aureus (MRSA). Larvae were separated into six weight groups (180–300 mg at 20 mg intervals) and infected with a range of doses of MRSA to determine the 50% lethal dose (LD50), and the ‘lipid weight’ of larvae post-infection was quantified. A model of LD50 values correlated with weight was developed. The LD50 values, as estimated by our model, were further tested in …

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Accounting For Benefits From Natural Capital: Applying A Novel Composite Indicator Framework To The Marine Environment, Emily Stebbings, Tara Hooper, Melanie C. Austen, Eleni Papathanasopoulou, Xiaoyu Yan Jan 2021

Accounting For Benefits From Natural Capital: Applying A Novel Composite Indicator Framework To The Marine Environment, Emily Stebbings, Tara Hooper, Melanie C. Austen, Eleni Papathanasopoulou, Xiaoyu Yan

School of Biological and Marine Sciences

No abstract provided.

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Bright Spots As Climate‐Smart Marine Spatial Planning Tools For Conservation And Blue Growth, Ana M. Queirós, Elizabeth Talbot, Nicola J. Beaumont, Paul J. Somerfield, Susan Kay, Christine Pascoe, Simon Dedman, Jose A. Fernandes, Alexander Jueterbock, Peter I. Miller, Sevrine F. Sailley, Gianluca Sará, Liam M. Carr, Melanie C. Austen, Steve Widdicombe, Gil Rilov, Lisa A. Levin, Stephen C. Hull, Suzannah F. Walmsley, Aonghusa C Nic Jan 2021

Bright Spots As Climate‐Smart Marine Spatial Planning Tools For Conservation And Blue Growth, Ana M. Queirós, Elizabeth Talbot, Nicola J. Beaumont, Paul J. Somerfield, Susan Kay, Christine Pascoe, Simon Dedman, Jose A. Fernandes, Alexander Jueterbock, Peter I. Miller, Sevrine F. Sailley, Gianluca Sará, Liam M. Carr, Melanie C. Austen, Steve Widdicombe, Gil Rilov, Lisa A. Levin, Stephen C. Hull, Suzannah F. Walmsley, Aonghusa C Nic

School of Biological and Marine Sciences

No abstract provided.

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Role Of Future Reef Growth On Morphological Response Of Coral Reef Islands To Sea‐Level Rise, G. Masselink, R. Mccall, E. Beetham, P. Kench, C. Storlazzi Jan 2021

Role Of Future Reef Growth On Morphological Response Of Coral Reef Islands To Sea‐Level Rise, G. Masselink, R. Mccall, E. Beetham, P. Kench, C. Storlazzi

School of Biological and Marine Sciences

No abstract provided.

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Chitosan Inhibits Septin‐Mediated Plant Infection By The Rice Blast Fungus Magnaporthe Oryzae In A Protein Kinase C And Nox1 Nadph Oxidase‐Dependent Manner, F Lopez‐Moya, M Martin‐Urdiroz, M Oses‐Ruiz, Vincent M. Were, Mark D. Fricker, George Littlejohn, Lv Lopez‐Llorca, Nicholas J. Talbot Jan 2021

Chitosan Inhibits Septin‐Mediated Plant Infection By The Rice Blast Fungus Magnaporthe Oryzae In A Protein Kinase C And Nox1 Nadph Oxidase‐Dependent Manner, F Lopez‐Moya, M Martin‐Urdiroz, M Oses‐Ruiz, Vincent M. Were, Mark D. Fricker, George Littlejohn, Lv Lopez‐Llorca, Nicholas J. Talbot

School of Biological and Marine Sciences

No abstract provided.

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Measuring Individual And Group Flow In Collaborative Improvisational Dance, Klara Łucznik, Jon May Jan 2021

Measuring Individual And Group Flow In Collaborative Improvisational Dance, Klara Łucznik, Jon May

School of Psychology

This study investigated flow experience during group collaborations of creative dance improvisation, where group flow was defined as periods when most members of a group reported a flow experience. Sixteen dancers took part in the experimental sessions, performing improvisational tasks in groups of four. We chose two different types of dance task, hypothesising that dancers’ external focus upon the group's shared surroundings and awareness of others might facilitate group flow experience; while an internal focus upon one's own mental imagery might inhibit it. A novel, video-stimulated recall method to assess flow experience was used to track time patterns and shared …

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Good Enough For Governance? Audit And Marine Biodiversity Offsetting In Australia, Holly J. Niner, Samuel Randalls Jan 2021

Good Enough For Governance? Audit And Marine Biodiversity Offsetting In Australia, Holly J. Niner, Samuel Randalls

School of Biological and Marine Sciences

Biodiversity offsetting is often presented as a way to manage competing demands of environmental protection and economic development. It is premised on the transparent demonstration of how aims of no net loss of biodiversity (NNL) or similar are met in practice. This is complicated in marine systems where ecological predictions are commonly highly uncertain, knowledge of ecological restoration is low and administrative governance is complex. Drawing on a case study of marine biodiversity offsetting in Australia, this paper shows how these uncertainties pose practical challenges for both producers and consumers of marine biodiversity offsets, needing to progress with decision-making while …

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Current State-Of-The-Art Diagnostics For Norovirus Detection: Model Approaches For Point-Of-Care Analysis, Maja A. Zaczek-Moczydlowska, Azadeh Beizaei, Michael Dillon, Katrina Campbell Jan 2021

Current State-Of-The-Art Diagnostics For Norovirus Detection: Model Approaches For Point-Of-Care Analysis, Maja A. Zaczek-Moczydlowska, Azadeh Beizaei, Michael Dillon, Katrina Campbell

Peninsula Medical School

No abstract provided.

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The Role Of Kelp In The Transport And Fate Of Negatively Buoyant Marine Plastic, Andrew Turner, Tracey Williams Jan 2021

The Role Of Kelp In The Transport And Fate Of Negatively Buoyant Marine Plastic, Andrew Turner, Tracey Williams

School of Geography, Earth and Environmental Sciences

No abstract provided.

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A Comparison Of The Quality Of Image Acquisition Between Two Different Sidestream Dark Field Video-Microscopes, Jonny Coppel, Vassiliki Bountziouka, Daniel Martin, Edward Gilbert-Kawai Jan 2021

A Comparison Of The Quality Of Image Acquisition Between Two Different Sidestream Dark Field Video-Microscopes, Jonny Coppel, Vassiliki Bountziouka, Daniel Martin, Edward Gilbert-Kawai

Peninsula Medical School

AbstractSidestream dark field (SDF) imaging enables direct visualisation of the microvasculature from which quantification of key variables is possible. The new MicroScan USB3 (MS-U) video-microscope is a hand-held SDF device that has undergone significant technical upgrades from its predecessor, the MicroScan Analogue (MS-A). The MS-U claims superior quality of sublingual microcirculatory image acquisition over the MS-A, however, this has yet to be robustly confirmed. In this manuscript, we therefore compare the quality of image acquisition between these two devices. The microcirculation of healthy volunteers was visualised to generate thirty video images for each device. Two independent raters, blinded to the …

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Handling The Heat: Responses Of Two Congeneric Limpet Species To Environmental Temperature Differences, Jc Redfern, A Foggo, N Mieszkowska Jan 2021

Handling The Heat: Responses Of Two Congeneric Limpet Species To Environmental Temperature Differences, Jc Redfern, A Foggo, N Mieszkowska

School of Biological and Marine Sciences

No abstract provided.

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Cardiopulmonary Exercise Testing And Cardiopulmonary Morbidity In Patients Undergoing Major Head And Neck Surgery, B. B. Lalabekyan, N. Tetlow, R. Moonesinghe, D. Martin, E. Burdett, J. Otto, D. Wyndham, E. Bettini, N. Kalavrezos, R. C.M. Stephens Jan 2021

Cardiopulmonary Exercise Testing And Cardiopulmonary Morbidity In Patients Undergoing Major Head And Neck Surgery, B. B. Lalabekyan, N. Tetlow, R. Moonesinghe, D. Martin, E. Burdett, J. Otto, D. Wyndham, E. Bettini, N. Kalavrezos, R. C.M. Stephens

Peninsula Medical School

No abstract provided.

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Editorial: Can Quantitative Fibrosis Assessment Be Used To Enhance Prediction Of Outcomes In Patients With Alcohol-Related Liver Disease?, Prebashan Moodley, Ashwin D. Dhanda Jan 2021

Editorial: Can Quantitative Fibrosis Assessment Be Used To Enhance Prediction Of Outcomes In Patients With Alcohol-Related Liver Disease?, Prebashan Moodley, Ashwin D. Dhanda

Peninsula Medical School

No abstract provided.

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Effects Of Perioperative Oxygen Concentration On Oxidative Stress In Adult Surgical Patients: A Systematic Review, Alexander H. Oldman, Daniel S. Martin, Martin Feelisch, Michael P.W. Grocott, Andrew F. Cumpstey Jan 2021

Effects Of Perioperative Oxygen Concentration On Oxidative Stress In Adult Surgical Patients: A Systematic Review, Alexander H. Oldman, Daniel S. Martin, Martin Feelisch, Michael P.W. Grocott, Andrew F. Cumpstey

Peninsula Medical School

No abstract provided.

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Assessment Of Hepatic Steatosis By Controlled Attenuation Parameter Using The M And Xl Probes: An Individual Patient Data Meta-Analysis, David Petroff, Valentin Blank, Philip N. Newsome, Shalimar, Cosmin Sebastian Voican, Maja Thiele, Lédinghen V De, Stephan Baumeler, Wah Kheong Chan, Gabriel Perlemuter, Ana Carolina Cardoso, Sandeep Aggarwal, Magali Sasso, Peter J. Eddowes, Michael Allison, Emmanuel Tsochatzis, Quentin M. Anstee, David Sheridan, Jeremy F. Cobbold, Sylvie Naveau, Monica Lupsor-Platon, Sebastian Mueller, Aleksander Krag, Marie Irles-Depe, David Semela, Gl-H Wong, Vw-S Wong, Cristiane A. Villela-Nogueira, Harshit Garg, Harshit Garg, Johannes Wiegand, Thomas Karlas Jan 2021

Assessment Of Hepatic Steatosis By Controlled Attenuation Parameter Using The M And Xl Probes: An Individual Patient Data Meta-Analysis, David Petroff, Valentin Blank, Philip N. Newsome, Shalimar, Cosmin Sebastian Voican, Maja Thiele, Lédinghen V De, Stephan Baumeler, Wah Kheong Chan, Gabriel Perlemuter, Ana Carolina Cardoso, Sandeep Aggarwal, Magali Sasso, Peter J. Eddowes, Michael Allison, Emmanuel Tsochatzis, Quentin M. Anstee, David Sheridan, Jeremy F. Cobbold, Sylvie Naveau, Monica Lupsor-Platon, Sebastian Mueller, Aleksander Krag, Marie Irles-Depe, David Semela, Gl-H Wong, Vw-S Wong, Cristiane A. Villela-Nogueira, Harshit Garg, Harshit Garg, Johannes Wiegand, Thomas Karlas

Peninsula Medical School

No abstract provided.

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Evaluation Of A Primary Care-Based Collaborative Care Model (Partners2) For People With Diagnoses Of Schizophrenia, Bipolar, Or Other Psychoses: Study Protocol For A Cluster Randomised Controlled Trial, Humera Plappert, Charley Hobson-Merrett, Bliss Gibbons, Elina Baker, Sheridan Bevan, Michael Clark, Siobhan Creanor, Linda Davies, Rebecca Denyer, Julia Frost, Linda Gask, John Gibson, Laura Gill, Ruth Gwernan-Jones, Pollyanna Hardy, Joanne Hosking, Peter Huxley, Alison Jeffrey, Benjamin Jones, Steven Marwaha, Vanessa Pinold, Claire Planner, Tim Rawcliffe, Siobhan Reilly, Debra Richards, Lynsey Williams, Max Birchwood, Richard Byng Jan 2021

Evaluation Of A Primary Care-Based Collaborative Care Model (Partners2) For People With Diagnoses Of Schizophrenia, Bipolar, Or Other Psychoses: Study Protocol For A Cluster Randomised Controlled Trial, Humera Plappert, Charley Hobson-Merrett, Bliss Gibbons, Elina Baker, Sheridan Bevan, Michael Clark, Siobhan Creanor, Linda Davies, Rebecca Denyer, Julia Frost, Linda Gask, John Gibson, Laura Gill, Ruth Gwernan-Jones, Pollyanna Hardy, Joanne Hosking, Peter Huxley, Alison Jeffrey, Benjamin Jones, Steven Marwaha, Vanessa Pinold, Claire Planner, Tim Rawcliffe, Siobhan Reilly, Debra Richards, Lynsey Williams, Max Birchwood, Richard Byng

Peninsula Medical School

BackgroundCurrent NHS policy encourages an integrated approach to provision of mental and physical care for individuals with long term mental health problems. The ‘PARTNERS2’ complex intervention is designed to support individuals with psychosis in a primary care setting.AimThe trial will evaluate the clinical and cost-effectiveness of the PARTNERS2 intervention.Design & settingThis is a cluster randomised controlled superiority trial comparing collaborative care (PARTNERS2) with usual care, with an internal pilot to assess feasibility. The setting will be primary care within four trial recruitment areas: Birmingham & Solihull, Cornwall, Plymouth, and Somerset. GP practices are randomised 1:1 to either (a) the PARTNERS2 …

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A Feasibility Randomised Controlled Trial Of Targeted Oxygen Therapy In Mechanically Ventilated Critically Ill Patients, Daniel S. Martin, Margaret Mcneil, Chris Brew-Graves, Helder Filipe, Ronan O’Driscoll, Jia Liu Stevens, Rachel Burnish, Andrew F. Cumpstey, Norman R. Williams, Michael G. Mythen, Michael P.W. Grocott Jan 2021

A Feasibility Randomised Controlled Trial Of Targeted Oxygen Therapy In Mechanically Ventilated Critically Ill Patients, Daniel S. Martin, Margaret Mcneil, Chris Brew-Graves, Helder Filipe, Ronan O’Driscoll, Jia Liu Stevens, Rachel Burnish, Andrew F. Cumpstey, Norman R. Williams, Michael G. Mythen, Michael P.W. Grocott

Peninsula Medical School

Background Despite oxygen being the commonest drug administered to critically ill patients we do not know which oxygen saturation (SpO2) target results in optimal survival outcomes in those receiving mechanical ventilation. We therefore conducted a feasibility randomised controlled trial in the United Kingdom (UK) to assess whether it would be possible to host a larger national multi-centre trial to evaluate oxygenation targets in mechanically ventilated patients. Methods We set out to recruit 60 participants across two sites into a trial in which they were randomised to receive conservative oxygenation (SpO2 88–92%) or usual care (control – SpO2 ≥96%). The primary …

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Fertility And Digital Technology: Narratives Of Using Smartphone App ‘Natural Cycles’ While Trying To Conceive, Pippa Grenfell, Nerissa Tilouche, Jill Shawe, Rebecca S. French Jan 2021

Fertility And Digital Technology: Narratives Of Using Smartphone App ‘Natural Cycles’ While Trying To Conceive, Pippa Grenfell, Nerissa Tilouche, Jill Shawe, Rebecca S. French

School of Nursing and Midwifery

No abstract provided.

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Physiological Responses During Ascent To High Altitude And The Incidence Of Acute Mountain Sickness, Alexandra B. Cobb, Denny Z.H. Levett, K Mitchell, Wynne Aveling, D Hurlbut, E Gilbert‐Kawai, Philip J. Hennis, Mg Mythen, Michael P.W. Grocott, Ds Martin, V. Ahuja, G Aref‐Adib, R. Burnham, A. Chisholm, K. Clarke, D Coates, M Coates, D. Cook, M. Cox, S. Dhillon, C. Dougall, P. Doyle, P. Duncan, M. Edsell, L. Edwards, L. Evans, P. Gardiner, Michael P.W. Grocott, P. Gunning, J. Harrington, J. Harrington, J. Harvey, C. Holloway, D. Howard, D Hurlbut, C. Imray, C. Ince, Der Kaaij J Van, M. Khosravi, N. Kolfschoten, Denny Z.H. Levett, H Luery, A. Luks, D Martin, R. Mcmorrow, P. Meale, K Mitchell, H. Montgomery, G Morgan, J Morgan, A. Murray, M Mythen, S Newman, V O’Dwyer, J Pate, T Plant, V Pun, P Richards, A Richardson, G Rodway, J Simpson, C Stroud, M Stroud, J Stygal, B Symons, P Szawarski, Tulleken A Van, Tulleken C Van, A Vercueil, L Wandrag, M Wilson, J Windsor, B Basnyat, K. Clarke, T Hornbein, J Milledge, J West, S Abraham, T Adams, W Anseeuw, R Astin, B Basnyat, O Burdall, J Carroll, Alexandra B. Cobb, J Coppel, O Couppis, J Court, A Cumpstey, T Davies, S. Dhillon, N Diamond, C. Dougall, T Geliot, E Gilbert‐Kawai, G Gilbert‐Kawai, E Gnaiger, M Grocott, C Haldane, P Hennis, J Horscroft, D Howard, S Jack, B Jarvis, W Jenner, G Jones, J Van Der Kaaij, J Kenth, A Kotwica, R Kumar Bc, J Lacey, V Laner, D Levett, D Martin, P Meale, K Mitchell, Z Mahomed, J Moonie, A Murray, M Mythen, P Mythen, K O’Brien, I Ruggles‐Brice, K Salmon, A Sheperdigian, T Smedley, B Symons, C Tomlinson, A Vercueil, L Wandrag, S Ward, A Wight, C Wilkinson, S Wythe, M Feelisch, E Gilbert‐Kawai, M Grocott, M Hanson, D Levett, D Martin, K Mitchell, H Montgomery, R Moon, A Murray, M Mythen, M Peters Jan 2021

Physiological Responses During Ascent To High Altitude And The Incidence Of Acute Mountain Sickness, Alexandra B. Cobb, Denny Z.H. Levett, K Mitchell, Wynne Aveling, D Hurlbut, E Gilbert‐Kawai, Philip J. Hennis, Mg Mythen, Michael P.W. Grocott, Ds Martin, V. Ahuja, G Aref‐Adib, R. Burnham, A. Chisholm, K. Clarke, D Coates, M Coates, D. Cook, M. Cox, S. Dhillon, C. Dougall, P. Doyle, P. Duncan, M. Edsell, L. Edwards, L. Evans, P. Gardiner, Michael P.W. Grocott, P. Gunning, J. Harrington, J. Harrington, J. Harvey, C. Holloway, D. Howard, D Hurlbut, C. Imray, C. Ince, Der Kaaij J Van, M. Khosravi, N. Kolfschoten, Denny Z.H. Levett, H Luery, A. Luks, D Martin, R. Mcmorrow, P. Meale, K Mitchell, H. Montgomery, G Morgan, J Morgan, A. Murray, M Mythen, S Newman, V O’Dwyer, J Pate, T Plant, V Pun, P Richards, A Richardson, G Rodway, J Simpson, C Stroud, M Stroud, J Stygal, B Symons, P Szawarski, Tulleken A Van, Tulleken C Van, A Vercueil, L Wandrag, M Wilson, J Windsor, B Basnyat, K. Clarke, T Hornbein, J Milledge, J West, S Abraham, T Adams, W Anseeuw, R Astin, B Basnyat, O Burdall, J Carroll, Alexandra B. Cobb, J Coppel, O Couppis, J Court, A Cumpstey, T Davies, S. Dhillon, N Diamond, C. Dougall, T Geliot, E Gilbert‐Kawai, G Gilbert‐Kawai, E Gnaiger, M Grocott, C Haldane, P Hennis, J Horscroft, D Howard, S Jack, B Jarvis, W Jenner, G Jones, J Van Der Kaaij, J Kenth, A Kotwica, R Kumar Bc, J Lacey, V Laner, D Levett, D Martin, P Meale, K Mitchell, Z Mahomed, J Moonie, A Murray, M Mythen, P Mythen, K O’Brien, I Ruggles‐Brice, K Salmon, A Sheperdigian, T Smedley, B Symons, C Tomlinson, A Vercueil, L Wandrag, S Ward, A Wight, C Wilkinson, S Wythe, M Feelisch, E Gilbert‐Kawai, M Grocott, M Hanson, D Levett, D Martin, K Mitchell, H Montgomery, R Moon, A Murray, M Mythen, M Peters

Peninsula Medical School

No abstract provided.

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Clarifying Realist Analytic And Interdisciplinary Consensus Processes In A Complex Health Intervention: A Worked Example Of Judgemental Rationality In Action, Sarah Rybczynska-Bunt, Lauren Weston, Richard Byng, Alex Stirzaker, Charlotte Lennox, Mark Pearson, Sarah Brand, Mike Maguire, Graham Durcan, Jonathan Graham, Sarah Leonard, Jenny Shaw, Tim Kirkpatrick, Christabel Owens, Cath Quinn Jan 2021

Clarifying Realist Analytic And Interdisciplinary Consensus Processes In A Complex Health Intervention: A Worked Example Of Judgemental Rationality In Action, Sarah Rybczynska-Bunt, Lauren Weston, Richard Byng, Alex Stirzaker, Charlotte Lennox, Mark Pearson, Sarah Brand, Mike Maguire, Graham Durcan, Jonathan Graham, Sarah Leonard, Jenny Shaw, Tim Kirkpatrick, Christabel Owens, Cath Quinn

Peninsula Medical School

Judgemental rationality is infrequently referenced within discussions of Realist Evaluations. Judgemental rationality refers to researchers’ capacity to assess which, potential, meanings provide the most credible explanations. In evaluation work, rationale for analysis is provided, though rarely do we see how an evaluator made judgements between competing theories, and which theories were discarded and why. We provide a worked example of the application of judgemental rationality. The Engager intervention offered support to prison leavers with common mental health problems. The data for 24, purposively sampled, participants from the intervention arm of the trial were integrated. Bhaskar’s DREIC, a five-step analytical procedure, …

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Editorial: Extending The Evidence For If And How Physical Activity Can Support Positive Changes Among Substance Users, Adrian H. Taylor, Tom P. Thompson, Ana Abrantes, Mats Hallgren Jan 2021

Editorial: Extending The Evidence For If And How Physical Activity Can Support Positive Changes Among Substance Users, Adrian H. Taylor, Tom P. Thompson, Ana Abrantes, Mats Hallgren

Peninsula Medical School

No abstract provided.

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Mental Health And Physical Activity, Yoga And Other Holistic Movement Practices (Hmps): A Position Statement, Adrian Taylor, Ana Abrantes, Mats Hallgren, Matthew Herring, Caterina Pesce, Simon Rosenbaum, Megan Teychenne Jan 2021

Mental Health And Physical Activity, Yoga And Other Holistic Movement Practices (Hmps): A Position Statement, Adrian Taylor, Ana Abrantes, Mats Hallgren, Matthew Herring, Caterina Pesce, Simon Rosenbaum, Megan Teychenne

Peninsula Medical School

No abstract provided.

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Preliminary Development Of A Questionnaire To Measure The Extra-Pulmonary Symptoms Of Severe Asthma, Felice G De, Michael E. Hyland, Joseph W. Lanario, Yuri Antonacci, Rupert C. Jones, Matthew Masoli Jan 2021

Preliminary Development Of A Questionnaire To Measure The Extra-Pulmonary Symptoms Of Severe Asthma, Felice G De, Michael E. Hyland, Joseph W. Lanario, Yuri Antonacci, Rupert C. Jones, Matthew Masoli

School of Psychology

Abstract Background Research into the effects of asthma treatments on the extra-pulmonary symptoms of severe asthma is limited by the absence of a suitable questionnaire. The aim was to create a questionnaire suitable for intervention studies by selecting symptoms that are statistically associated with asthma pathology and therefore may improve when pathology is reduced. Methods Patients attending a specialist asthma clinic completed the 65-item General Symptom Questionnaire (GSQ-65), a questionnaire validated for assessing symptoms of people with multiple medically unexplained symptoms. Lung function (FEV1%) and cumulative oral corticosteroids (OCS) calculated from maintenance dose plus exacerbations were obtained from clinic records. …

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The Second World Ocean Assessment Volume 1, Jason Hall-Spencer, Louise Firth Jan 2021

The Second World Ocean Assessment Volume 1, Jason Hall-Spencer, Louise Firth

School of Biological and Marine Sciences

In its resolutions 57/141 and 58/240, the General Assembly decided to establish a regular processunder the United Nations for global reporting and assessment of the state of the marineenvironment, including socioeconomic aspects, both current and foreseeable, building on existingregional assessments. In its resolution 71/257, the Assembly recalled that the scope of thefirst cycle of the Regular Process focused on establishing a baseline and decided that the scopeof the second cycle would extend to evaluating trends and identifying gaps. The programme ofwork for the period 2017–2020 of the second cycle of the Regular Process includes the preparationby the Group of Experts …

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Julian Stander, Katerina Tzioli And Mario Cortina Borja: 200 Years Of Greek Independence… And Pms, J Stander, K Tzioli, Borja M Cortina Jan 2021

Julian Stander, Katerina Tzioli And Mario Cortina Borja: 200 Years Of Greek Independence… And Pms, J Stander, K Tzioli, Borja M Cortina

School of Engineering, Computing and Mathematics

No abstract provided.

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The Relationship Between Gestational Weight Gain, Maternal Upper-Body Subcutaneous Fat Changes And Infant Birth Size: A Pilot Observational Study Amongst Women With Obesity, Kathy M. Redfern, Heidi J. Hollands, Joanne Hosking, C. Ross Welch, Jonathan H. Pinkney, Gail A. Rees Jan 2021

The Relationship Between Gestational Weight Gain, Maternal Upper-Body Subcutaneous Fat Changes And Infant Birth Size: A Pilot Observational Study Amongst Women With Obesity, Kathy M. Redfern, Heidi J. Hollands, Joanne Hosking, C. Ross Welch, Jonathan H. Pinkney, Gail A. Rees

School of Biomedical Sciences

No abstract provided.

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What Do We Know About Business Strategy And Environmental Research? Insights From Business Strategy And The Environment, S Kumar, R Sureka, Wm Lim, Mangla S Kumar, N Goyal Jan 2021

What Do We Know About Business Strategy And Environmental Research? Insights From Business Strategy And The Environment, S Kumar, R Sureka, Wm Lim, Mangla S Kumar, N Goyal

Plymouth Business School

No abstract provided.

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Effect Of Methionine Feeding On Oxidative Stress, Intracellular Calcium And Contractility In Cardiomyocytes Isolated From Male And Female Rats, Shatha A. Demerchi, Nicola King, James R. Mcfarlane, Pierre D.J. Moens Jan 2021

Effect Of Methionine Feeding On Oxidative Stress, Intracellular Calcium And Contractility In Cardiomyocytes Isolated From Male And Female Rats, Shatha A. Demerchi, Nicola King, James R. Mcfarlane, Pierre D.J. Moens

School of Biomedical Sciences

Homocysteine (Hcy) is a breakdown product of methionine metabolism. The risk of cardiovascular disease (CVD) correlates with an increase in plasma Hcy levels. The aim of this study was to investigate whether 1% methionine supplementation of adult rats altered intracellular reactive oxygen species (ROS) generation, intracellular Ca2+ content, and contractile activity in freshly isolated cardiomyocytes. This was measured under normal conditions and during oxidative stress in freshly isolated cardiomyocytes. Single rat cardiomyocytes from both sexes were isolated by enzymatic and mechanical dispersion techniques. Fluorescence microscopy was used to measure ROS production and intracellular Ca2+ concentration. Cell contraction was measured using …

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Htk Versus Multidose Cardioplegias For Myocardial Protection In Adult Cardiac Surgery: A Meta‐Analysis, Alexander C. Reynolds, Sanjay Asopa, Amit Modi, Nicola King Jan 2021

Htk Versus Multidose Cardioplegias For Myocardial Protection In Adult Cardiac Surgery: A Meta‐Analysis, Alexander C. Reynolds, Sanjay Asopa, Amit Modi, Nicola King

School of Biomedical Sciences

No abstract provided.

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