Digital Commons Network^™

Assessing Language Delay In Twins: Low Gesture Use And Birth History Factors, Lori G. Foran, Kelli J. Evans, Brenda L. Beverly

Brenda L. Beverly Publications

Identification of language disorders in children younger than 3 years remains challenging despite agreement that early intervention improves outcomes. This study of twin language and gesture development substantiated the twinning effect, an unexplained lag in expressive and receptive language seen in twins, for a group of 88, 16- to 18-month-old twins who did not present with extreme perinatal risk. A valid, parent-report measure revealed word production ≤10^th percentile for 15 twins. Pregnancy complications, but not a positive family history of speech, language or learning disorders or other case history factors, significantly increased the odds of this early expressive delay. …

Utilizing An Instructional Intervention In Aquatics: An Experimental Study For Improving Wellness Awareness In Adults, Felisa Fayette Mastel

Education

The medical community recognizes the importance of regular, vigorous exercise. The evidence is indeed overwhelming in support of physical fitness for the prevention of disease and disability; yet nearly 80% of the population does not exercise enough to produce a health benefit (CDC, 2018). Thus, it is necessary to find a way to assist individuals to increase an awareness concerning physical fitness and furthermore, overall wellness awareness. This quantitative study’s instructional intervention treatment interlaced the six dimensions of wellness and Knowles andragogy interwoven within a single activity; in this case water exercise. Hence, the purpose of this study was to …

Redefining What's Manly: Using Masculine Attributes To Describe Counseling Services For Men, Riley Nicholas Rodemaker

Dissertations and Theses @ UNI

Men are diagnosed with mental illness at a similar rate to women, and men deal with similar levels of impairment (Kessler et al., 1994). Despite this impairment, men do not seek help for their mental health as often as women do (Smith et al., 2013). One reason may be that counseling is seen as feminine. In this thesis, I describe an experimental study that examined the effect of using masculine attributes to describe counseling services on men’s attitudes. Adult male participants ages 18 to 35 (N = 818) read a short story that featured a conversation with a friend that …

Examining Individual Differences In Attitudes Toward The Insanity Defense, Dominique M. Kornely

Dissertations and Theses @ UNI

The purpose of the present study was to examine how individual differences in stigma against people who are mentally ill, free will beliefs, just world beliefs, and sentencing goals are associated with attitudes toward the insanity defense. Because there are many misconceptions about what the insanity defense is, and how it is actually used as a sentence, the Not Guilty by Reason of Insanity (NGRI) plea may be underutilized due to public opinions reflecting misunderstanding and/or possible biases (Perlin, 2017). Understanding the relation between individual beliefs and attitudes about the insanity defense would help to better understand potential biases present …

Advocates And Researchers Working Together To Improve School Health Education, Joseph Donnelly, Michael Young, Katherine J. Roberts

Department of Public Health Scholarship and Creative Works

Purpose: This article discusses the need for continued evaluation of health education interventions/curricula and provides tools and resources to facilitate the selection of appropriate, evidencebased interventions/curricula for school health education programs. Methods: We review the literature related to the evaluation of school health education programs, provide a review of the basics for understanding evaluation design and results, and identify resources for selecting effective curricula. Conclusions: There is a need for additional rigorously designed evaluations of school health education programs. School health educators and other advocates for school health education must have a basic understanding of evaluation design and how to …

Executive Functions And Writing Skills In Children With And Without Adhd, Elia F. Soto, Lauren N. Irwin, Elizabeth S.M. Chan, Jamie A. Spiegel, Michael J. Kofler

Department of Psychology Faculty Scholarship and Creative Works

Pediatric attention-deficit/hyperactivity disorder (ADHD) has been associated with impairments in executive functioning and academic writing skills. However, our understanding of the extent to which these children’s writing difficulties are related to their underdeveloped executive functions—and whether this relation is attributable to specific executive functions—is limited. Method: A clinically-evaluated and carefullyphenotyped sample of 91 children ages 8–13 (M = 10.60, SD = 1.25; 37 girls) were administered multiple, counterbalanced tests of the three core executive functions (working memory, inhibitory control, set shifting), assessed for ADHD symptoms via multiple-informant reports, and completed standardized, norm-referenced testing of three core writing skills (written expression, …

Tele-Forensic Interviewing Can Be A Reasonable Alternative To Face-To-Face Interviewing Of Child Witnesses., Jason J. Dickinson, Nicole E. Lytle, Debra Ann Poole

Department of Psychology Faculty Scholarship and Creative Works

Objective: Tele-forensic interviews have the potential to aid investigations when children live far from interviewers, there is a risk of disease transmission, or when expertise is not locally available. However, it is unknown whether tele-forensic interviewing is an effective alternative to face-to-face interviewing, particularly for children most prone to suggestibility and lapses of attention. Hypotheses: Previous studies suggested that school-age children would provide similar amounts of information across interview modes but provided no basis for predicting how misinformation impacts accuracy across modes or how 4- and 5-year-olds would react to tele-forensic interviewing. Method: Children (4–8 years, N = 261, Mage …

The Editors’ Perspective: Online Teaching And Learning In A Pandemic, Cindy L. Hayden, Dana M. Howell, Renee Causey-Upton

Journal of Occupational Therapy Education

No abstract provided.

Kinesthetic Learners During The Covid-19 Pandemic: Occupational Therapy Students’ Perspective On E-Learning, Michael Stamm, Kailey Francetic, Regina Reilly, Angela Tharp, Nicole Thompson, Ryleigh Weidenhamer

Journal of Occupational Therapy Education

The purpose of the study was to understand the perspective of kinesthetic learners in an online learning environment. A Microsoft Forms survey was created and distributed to the sample population using the university electronic mailing list. If self-identified as kinesthetic learners, subjects were asked to participate in a semi-structured focus group. Twenty-six subjects responded to the survey, with 73% (n=19) identifying as kinesthetic learners. Quantitative results showed subjects felt most confident in content comprehension but less confident in clinical application. Qualitative data collection led to emergence of the following four themes—advantages, disadvantages, accommodations to e-learning, and external factors. …

Clinical And Professional Reasoning Development In Level Ii Fieldwork: Occupational Therapy Assistant Students’ Perception, Marie-Christine Potvin, Jeanne M. Coviello, Eden Rothacker, Caitlin Taylor, Taryn Pettigrew, Mary Beth Thomas, Laronda Lockhart-Keene

Journal of Occupational Therapy Education

Occupational therapy academic programs are tasked with preparing occupational therapy assistant (OTA) students to develop and use clinical and professional reasoning in practice. A component of this academic education, Level II fieldwork (FW), develops clinical and professional reasoning by allowing students to practice this skill. Although numerous studies have investigated this topic in occupational therapy students, only one small study has previously investigated this in OTA students during Level II FW. Thus, we designed a mixed methods study of OTA students during Level II FW (n = 58) to confirm and expand our knowledge of learning experiences that develop …

Characterization Of Unintentionally Released Nanometric Particles In Various Workplaces, Maximilien Debia, Cyril Catto, Alan Fleck, Jean-Philippe Masse, Gilles L'Espérance, Brigitte Roberge

Rapports de recherche scientifique

Les particules nanométriques émises non intentionnellement (PNNI) en milieux de travail présentent un potentiel de toxicité pour les travailleurs. Elles montrent une importante capacité de se déposer dans le système respiratoire et se distinguent par leur grande surface spécifique et un potentiel élevé d’inflammation pulmonaire. Cette étude vise à caractériser les PNNI émises dans six milieux de travail à travers un large éventail d’indicateurs.

Les concentrations ont été évaluées selon les métriques numériques et massiques à l’aide d’une panoplie d’instruments à lecture directe (ILD). Des mesures intégrées ont aussi été effectuées en tenant compte du type de contaminant spécifique à …

Whole Issue (Winter 2021 / 21.2)

Chicago Journal of International Law

No abstract provided.

The Application Of International Tax Treaties To Digital Services Taxes, Katherine E. Karnosh

Chicago Journal of International Law

As digital services and electronic commerce have become more prevalent aspects of the global economy, there have been concerns over how tax systems will adapt to this change. International tax treaties in particular seem to be outdated and unprepared for the digital economy. Many international tax treaties provide that businesses are to be taxed on their income only in jurisdictions where they have a sufficient physical presence. By establishing their European headquarters and digital servers in countries with low corporate income tax rates (such as Ireland) and then using those headquarters to provide digital services to the rest of Europe, …

Gene Selection For Cancer Classification: A New Hybrid Filter-C5.0 Approach For Breast Cancer Risk Prediction, Mohammed Hamim, Ismail El Moudden, Hicham Moutachaouik, Mustapha Hain

Department of Medicine Faculty Publications

Despite the significant progress made in data mining technologies in recent years, breast cancer risk prediction and diagnosis at an early stage using DNA microarray technology still a real challenging task. This challenge comes especially from the high-dimensionality in gene expression data, i.e., an enormous number of genes versus a few tens of subjects (samples). To overcome this problem of data imbalance, a gene selection phase becomes a crucial step for gene expression data analysis. This study proposes a new Decision Tree model-based attributes (genes) selection strategy, which incorporates two stages: fisher-score-based filter technique and the gene selection ability of …

A Novel Dimensionality Reduction Approach To Improve Microarray Data Classification, Mohammed Hasim, Ismail El Mouden, Mounir Ouzir, Hicham Moutachaouik, Mustapha Hain

Department of Medicine Faculty Publications

Cancer tumor prediction and diagnosis at an early stage has become a necessity in cancer research, as it provides an increase in the treatment success chances. Recently, DNA microarray technology became a powerful tool for cancer identification, that can analyze the expression level of a different and huge number of genes simultaneously. In microarray data, the large genes number versus a few records may affect the prediction performance. In order to handle this "curse of dimensionality” constraint of microarray dataset while improving the cancer identification performance, a dimensional reduction phase is necessary. In this paper, we proposed a framework that …

"I Would If Only I Could": How California Cities Can Use State Law To Overcome Neighborhood Resistance To New Housing, Christopher S. Elmendorf, Eric Biber, Paavo Monkkonen, Moira O’Neill

Faculty Scholarship

No abstract provided.

Covid-19 Antibody Testing As A Precondition For Employment: Ethical And Legal Considerations, Sara Gerke, Gali Katznelson, Dorit R. Reiss, Carmel Shachar

Faculty Scholarship

Employers and governments are interested in the use of serological (antibody) testing to allow people to return to work before there is a vaccine for SARS-CoV-2. We articulate the preconditions needed for the implementation of antibody testing, including the role of the U.S. Food & Drug Administration.

Wilderness Law In The Anthropocene: Purism Or Pragmatism, Phillipa C. Mccormack, Benjamin J. Richardson, David Takacs, Kees Bastmeijer

Faculty Scholarship

Wilderness is vanishing. Despite explicit legislative protection of wilderness values for over half a century, rapid environmental degradation worldwide in recent decades has severely diminished the extent and quality of terrestrial and marine wilderness to the point where we must reassess the fundamental premises and future of wilderness law. With increased human demands on the natural world, and with climate breakdown looming, the very notion of “wilderness” itself may one day be considered meaningless or irrelevant. We examine legal developments in the United States, Australia, and Europe to critically evaluate the state of wilderness law. In this Anthropocene era, when …

Differential Etiology: Inferring Specific Causation In The Law From Group Data In Science, Joseph Sanders, David L. Faigman, Peter B. Imrey, Philip Dawid

Faculty Scholarship

In every toxic-tort case, the plaintiff must prove that the defendant exposed the plaintiff to something that caused an injury. The causal proof is in two parts: proof of general causation and proof of specific causation. General causation addresses the question of whether the exposure can cause injury in anyone. In the area of toxic torts, the evidence available to answer this question comes in the form of groupbasedstudies in the fields of toxicology, epidemiology, and genetics—studies that search for the effects of causes. Proof of general causation, however, is not enough. Because court cases focus on the individual, the …

The Political (Mis)Representation Of Immigrants On The Census, Ming Hsu Chen

Faculty Scholarship

Who is a member of the political community? What barriers to inclusion do immi- grants face as outsiders to this political community? This article describes several barriers facing immigrants that impede their political belonging. It critiques these barriers not on the basis of immigrants’ rights but based on their rights as current and future members of the political community. This is the second of two Essays. The first Essay focused on voting restrictions impacting Asian American and Latino voters. The second Essay focuses on challenges to including immigrants, Asian Americans, and Latinos in the 2020 Census. Together, the Essays critique …

Race, School Policing, And Public Health, Thalia Gonzalez

Faculty Scholarship

The ever-growing list of names of Black victims who have died at the hands ofpolice has emboldened a new public narrative that frames police violence—and other more commonplace, though less lethal, disparate policing practices—as a public health crisis rooted in this country’s history of racism and anti-Blackness. This public narrative in turn has spawned a diverse set of responsive actions in both the public and private sectors directed at addressing the effects of individual and structural racism on health. Yet missing from this linkage between police violence and racialized health disparities is any focus on the educational system, despite the …

Public Health Surveillance In The Context Of Covid-19, Jennifer D. Oliva

Faculty Scholarship

No abstract provided.

Clinical Activity Of Fianlimab (Regn3767), A Human Anti-Lag-3 Monoclonal Antibody, Combined With Cemiplimab (Anti-Pd-1) In Patients (Pts) With Advanced Melanoma, Guilherme Rabinowits

All Publications

No abstract provided.

Phase 1 Trial Of Alrn-6924, A Dual Inhibitor Of Mdmx And Mdm2, In Patients With Solid Tumors And Lymphomas Bearing Wild-Type Tp53, Guilherme Rabinowits

All Publications

Abstract

Purpose: We describe the first-in-human dose-escalation trial for ALRN-6924, a stabilized, cell-permeating peptide that disrupts p53 inhibition by MDM2 and MDMX to induce cell cycle arrest or apoptosis in TP53 wild-type tumors.

Methods: Two schedules were evaluated for safety, pharmacokinetics, pharmacodynamics, and anti-tumor effects in patients with solid tumors or lymphomas: In arm A, patients received ALRN-6924 by intravenous infusion once-weekly for 3 weeks every 28 days; arm B, was twice-weekly for 2 weeks every 21 days.

Results: Seventy-one patients were enrolled: 41 in arm A (0.16-4.4 mg/kg), 30 in arm B (0.32-2.7 mg/kg). ALRN-6924 showed dose-dependent pharmacokinetics and …

Occupational Exposure To Antineoplastic Drugs: What About Hospital Sanitation Personnel?, France Labrèche, Capucine Ouellet, Brigitte Roberge, Nicolas J Caron, Ahmed Yennek, Jean-François Bussières

Études primaires

Objective

Occupational exposure to antineoplastic drugs (ANPs) occurs mainly through dermal contact. Our study was set up to assess the potential exposure of hospital sanitation (HS) personnel, for whom almost no data are available, through contamination of surfaces they regularly touch.

Methods

In the oncology departments of two hospitals around Montreal, surface wipe samples of 120–2000 cm² were taken at 10 sites cleaned by the HS personnel and five other sites frequently touched by nursing and pharmacy personnel. A few hand wipe samples were collected to explore skin contamination. Wipes were analyzed by ultra-performance liquid chromatography tandem–mass spectrometry for …

Leakage Versus Material Filtration In Barrier Facemask Efficiency, Ali Bahloul, Clothilde Brochot, Barbara Layne

Études primaires

The World Health Association and many governmental agencies recommend the wearing of facemasks by the general public to prevent the spread of COVID-19. It is believed that masks can significantly protect others and may offer some protection to the wearer. Although there are standards for FFRs, surgical masks, and recently for barrier face coverings, they all indicate the level of protection for the wearer. However, testing facial masks not at the point of inhalation, but at the source, the exhale, offers a new perspective on how to impede particle emissions. In this paper, the experimental results show that, although the …

On The Removal Of The Open Earcanal High-Pass Filter Effect Due To Its Occlusion: A Bone-Conduction Occlusion Effect Theory, Kevin Carillo, Olivier Doutres, Franck Sgard

Études primaires

The occlusion effect is commonly experienced by in-ear device wearers as an increased loudness sensation of bone-conducted low frequency sounds. A widespread theory proposed by Tonndorf and based on a simplified electro-acoustic model describes the phenomenon as the removal of the open earcanal high-pass filter effect due to a perfect or partial occlusion. However, this filter has not been clearly defined and several ambiguities remain. Revisiting the model, a second order high-pass filter effect for the volume velocity transferred between the earcanal wall and the eardrum is highlighted. This filter remains for partial occlusion but vanishes for perfect occlusion. In …

Role And Responsibilities Of Supervisors In The Sustainable Return To Work Of Workers Following A Work-Related Musculoskeletal Disorder, Iuliana Nastasia, Marie-France Coutu, Romain Rives, Jessica Dubé, Sarah Gaspard, Audrey Quilicot

Études primaires

Purpose Supervisors play an important role during the return to work (RTW) of injured workers. Yet little research has been done on the actions associated with this role or the contexts in which they are taken. The purpose of this study was to develop courses of action to promote supervisors’ involvement in the process aimed at achieving sustainable RTW for workers following a work-related musculoskeletal disorder (MSD), and to verify their pertinence, feasibility, and applicability in practice. Methods A two-phase qualitative method was used. (1) Secondary content analysis of 46 interviews of 14 workers post-MSD and 32 other actors in …

Principle Of An Acoustical Method For Estimating The Centroid Position Of The Earcanal Wall Normal Velocity Induced By Bone-Conducted Stimulation: Numerical Evaluation, Kevin Carillo, Olivier Doutres, Franck Sgard

Études primaires

The occlusion effect is commonly experienced as the altered perception of one’s own physiological noise when the earcanal entrance is blocked. Objectively, this phenomenon corresponds to an acoustic pressure increase in the occluded earcanal. The occlusion effect originates from the earcanal wall normal vibration and depends on the spatial distribution of the latter. At low frequencies, this spatial distribution can be characterized by the position of its centroid along the earcanal middle axis. This paper describes the principle of an acoustical method for estimating this centroid position at low frequencies. The proposed method consists in measuring the eardrum acoustic pressure …

The Effect Of Extensible And Non-Extensible Lumbosacral Orthoses On Anticipatory Postural Adjustments In Participants With Low Back Pain And Healthy Controls, Christian Larivière, Richard Preuss

Études primaires

Background

Wearing a lumbosacral orthosis (LSO) is known to influence spine mechanics, but less is known about how LSOs affect motor control. Whether the use of a LSO can negatively affect motor control of the lumbar spine is still under debate.

Objective

The current study examined the immediate effects of two flexible LSOs (extensible and non-extensible) on the anticipatory postural adjustments that prepare the spine for a predictable perturbation.

Design

A comparative study using a repeated measures design in a laboratory setting.

Methods

Healthy controls (n = 20) and participants with low back pain (n = 40) performed a rapid …