Digital Commons Network^™

The Buffering Effects Of Resilience On Alcohol Use: A Phenotypic And Genotypic Investigation, Shannon Cusack

Theses and Dissertations

The college years encompass a time of vulnerability for problematic alcohol use/alcohol use disorder (AUD) and exposure to traumatic events (TE), which is a transdiagnostic risk factor for AUD, posttraumatic stress disorder (PTSD), and comorbid AUD-PTSD. However, not all who experience a TE develop these disorders, highlighting the need to identify factors that impact post-trauma outcomes. Resilience has been shown to be associated with lower alcohol consumption and related problems following TE, though the buffering effects of resilience on alcohol use have not yet been examined. Further, twin studies demonstrate that resilience is moderately heritable, but further research is needed …

Nurse Cognition In Response To Alert Generation During Bar Code Medication Administration (Bcma): An Examination Of Human Factors, Elizabeth A. Sloss

Theses and Dissertations

Introduction: Nurses are at the forefront of care delivery, spending more time with patients than most other providers. Paramount to patient safety is the ability for nurses to make clinical decisions free from human error. Yet, the dynamic clinical environment in which nurses work is characterized by uncertainty, urgency, and high consequence, necessitating that nurses make quick and critical decisions. Notably, medical errors related to clinical decision-making, including medication administration errors, may occur more frequently among new graduate nurses. Therefore, the aims of this dissertation study are to 1) examine patterns of alert generation and alert response decisions (decision outputs) …

Straight Through My Heart, Raul A. Aguilar Canela

Theses and Dissertations

Straight through my heart is an exhibition that explores the concept of heartbreak as a socio-political phenomenon. Through the affect of sadness the thesis analyses the way in which subjects are formed under cognitive capitalism. Paying particular interest to the collateral effects of neoliberal culture —hyper-stimulation, self-exploitation, competition, and obsession with productivity—and the pathologies they create —depression, anxiety, body aches, fatigue— this work shifts the burden of sadness from the individual to the community. By doing so it proposes heartbreak as a public feeling.

Perceived Efficacy Of Extrusion Of Maxillary Lateral Incisors With Aligners, Mason T. Bates

Theses and Dissertations

Purpose: To assess the perceived efficacy of aligners (Invisalign, Align Technology Inc) at performing extrusive movements of maxillary lateral incisors, determine a general threshold of when a maxillary lateral incisor is not extruding as predicted and requiring intervention, evaluate the frequency and methods of intervention to achieve the predicted extrusion, and to evaluate any related differences between orthodontists and general dentists, and between clinicians having treated various numbers of patients with Invisalign in the past 12 months.

Methods: An original 18-question survey was sent by mail to a randomized and geographically proportionate selection of orthodontic specialists (N = …

Il-36g Cytokine Induction In Oral Epithelial Cells Triggered By Treponema Denticola And Their Role In Chronic Periodontitis, Christopher Blake

Theses and Dissertations

Periodontal disease is a polymicrobial disease affecting 10-15% of the population. Periodontal disease affects the quality of life by reducing mastication and potentially causing tooth loss. Periodontal disease is also linked to more severe, systemic diseases such as cardiovascular disease and rheumatoid arthritis. Development of the diseased state occurs when the plaque biofilm shifts from healthy to dysbiotic. The shift to a dysbiotic biome brings with it a shift in bacterial presence, specifically an increase in gram-negative bacteria, such as T. denticola. T. denticola is a gram-negative, anaerobic spirochete whose relationship with oral epithelial cells is poorly understood. Preliminary data …

Hamburger Helper Recipes, John Alex Goss

Theses and Dissertations

Hamburger Helper Recipes is a collection of essays and public addresses that aim to recuperate castoff and misfit material surrounding industries and tools which produce science-fiction fantasies, specifically videogames and television shows. The following essays confront the normative violence of capitalism, whiteness, and hetero-patriarchy that socially and technologically haunt these imaginary worlds and build hegemonic idealogy into their audiences. This collection takes industrial materials and software from their intended commercial purposes of production and “success” into places of abjection and quiet breakdown. The author’s own proximity to masculine and often toxic "work cultures'' within industrial spaces of coding and manufacturing …

Patient Perspectives On Teledentistry And Face-To-Face Doctor Interaction During Orthodontic Treatment, Jackson K. Griffeth D.M.D.

Theses and Dissertations

Purpose: Orthodontic patients were surveyed to determine the perceived value of doctor-to-patient face-to-face interaction, the desire for convenience and attitudes toward specific uses of teledentistry.

Methods: Participating private practice orthodontists emailed the survey to active patients. 75 self-pay patients from VCU Orthodontic clinic were also invited to complete the survey. Patients 18 years or older were asked to complete the survey regarding their own treatment. Parents of patients under age 18 were asked to complete a separate survey regarding their child’s treatment. Questions asked patients about the importance of face-to-face interaction with their orthodontist and their preferences for the inclusion …

Radiographic Comparison Using Cbct-Pai And Volumetric Analysis Of Endodontically Treated Teeth: A Retrospective Cohort Study, Jeremy Hargrove

Theses and Dissertations

Purpose: To assess the changes in CBCT-PAI score as well as 3-D volume of periapical findings associated with endodontically treated roots and to see how these findings change over time.

Methods: Retrospective chart review with the following inclusion criteria: 1. At least one tooth was endodontically treated at the endodontic private practice; 2. Patient had a recall examination and the treated tooth was asymptomatic, functional and a CBCT was exposed; 3. CBCT interpretation found a periapical finding associated with the treated tooth; 4. A follow-up recall examination was completed and CBCT exposed. Cases that fulfilled the inclusion criteria had the …

Development Of Analytical Methods For Analysis Of Glycosaminoglycans And Their Mimetics In Human Plasma, Rawan M. Fayyad

Theses and Dissertations

Glycosaminoglycans (GAGs) are linear, polydisperse polysaccharides consisting of alternating amino sugars and either a uronic acid or galactose residue. They are ubiquitous components of the extracellular matrix and are present on cell surfaces and in basement membranes. GAGs are highly negatively charged as a result of many sulfate and carboxylic acid groups, and are extremely heterogeneous in both their structure and in their physicochemical properties. This complexity in structure is attributed to the alterations in residue types, glycosidic bond linkage, sulfation levels, sulfation positions, and chain lengths during biosynthesis. GAGs interact with a wide number of proteins and modulate various …

Molecular Basis Of Cross-Sensitization In Colonic Inflammation-Induced Somatic Hypersensitivity, Parshva K. Mehta

Theses and Dissertations

A major portion of pain experienced by patients with an Irritable Bowel Disease (IBD) or Irritable Bowel Syndrome (IBS) can be attributed to visceral hypersensitivity. Visceral stimuli transmitted through primary afferent neurons in the dorsal root ganglia (DRG) induce a nociceptive response. Notably, a subset of patients has also experienced the development of somatic pain, such as leg pain, after diagnosis of a bowel disorder. The aim of this investigation is to ascertain which biochemical mediators are involved in the development of such viscerosomatic cross-sensitization. Initially, the Von Frey Test was used to find behavioral evidence of somatic referred pain; …

Reproducibility And Accuracy Of The Virtual Occlusal Record, Anne M. Harper

Theses and Dissertations

Purpose: To evaluate the reproducibility and accuracy of the virtual occlusal record compared to the gold standard physical bite record

Methods: Two physical bite records of PVS and two virtual bites using an iTero Element scanner were obtained from 22 participants. Intraoral scans were exported as STL files, and virtual occlusal records were created. CBCT images were taken of physical occlusal records and converted to STL files. STL files were superimposed using Geomagic Control X™ Software. Root mean square (RMS) and percent similarity within 0.25 mm tolerance were compared at a significance level of 0.05.

Results: Average …

In Vitro Evaluation Of The Solubility Of Endosequence Bc Sealer In Acidic Solutions, Inderpal S. Sappal

Theses and Dissertations

Purpose: In recent years, bioceramic sealers (BCS), such as EndoSequence BC Sealer, have gained popularity in endodontic practices. Previous research has found BCS difficult to remove from canals during retreatments when compared with other endodontic sealers. Acidic solutions have been found to inhibit the set of BCS and increase their solubility. The purpose of this study was to evaluate the efficacy of acidic solutions in the removal of BCS as compared with a traditional retreatment solvent.

Methods: Roots of extracted human single rooted teeth (N=15) were prepared into 17 mm sections, then instrumented with ProTaper Gold (PTG) rotary files up …

Perovskite Thin Films Annealed In Supercritical Fluids For Efficient Solar Cells, Gilbert Annohene

Theses and Dissertations

In the field of photovoltaics, scientists and researchers are working fervently to produce a combination of efficient, stable, low cost and scalable devices. Methylammonium lead trihalide perovskite has attracted intense interest due to its high photovoltaic performance, low cost, and ease of manufacture. Their high absorption coefficient, tunable bandgap, low-temperature processing, and abundant elemental constituent provide innumerable advantages over other thin film absorber materials. Since the perovskite film is the most important in the device, morphology, crystallization, compositional and interface engineering have been explored to boost its performance and stability. High temperatures necessary for crystallization of organic-inorganic hybrid perovskite films …

Pro-Environmental Behaviors Among Black Environmentalists: A Critical Race Perspective, Kimberly S. Compton

Theses and Dissertations

Environmentalist narratives have left out the labor of Black environmentalists, mischaracterizing Black communities as disinterested in environmental problems or solutions. The purpose of this critical transformative exploratory qualitative study, guided by critical race theory, was to explore the meaning of pro-environmental behaviors among Black environmental advocates. Ten adult Black environmental advocates and organizers were interviewed using semi-structured interviews which were transcribed and analyzed using directed content analysis and thematic analysis. The findings demonstrated divergences between definitions of the environment and how that impacts what is considered pro-environmental behavior; the breadth of the pro-environmental behaviors in which Black environmentalists are engaged; …

The Just Host: Addressing The Wage Structure Problem In The Tourism Industry, Bill Farley

Theses and Dissertations

Since the early 1990’s, tourism development has been promoted to replace employment lost to downsizing, outsourcing and automation in both urban and rural America. These efforts are actively supported by state and local chambers of commerce. However, despite the enthusiasm for tourism within city halls and business membership organizations, planning theorists have expressed concerns about the wage structure of the industry. Specifically, given the significant public investment in the industry, planners are being asked by some theorists to consider the distribution of economic benefits between labor and capital. This dissertation explores this issue and concludes with a study focused on …

The Therapeutic Potential Of Glycosaminoglycan Directed Metalloglycomics: Elucidating New Targets And Mechanisms For Polynuclear Platinum Complexes, James D. Hampton

Theses and Dissertations

Cancer remains a serious clinical problem and in order to continue to improve patient health outcomes, novel treatment strategies must continue to be developed. Platinum chemotherapies remain as one of the most widely successful classes of cancer therapeutic, with over 50% of cancer patients receiving a platinate at some point over the span of their treatment. However, intrinsic and extrinsic resistances limit their effectiveness, long term efficacy, and broad applicability to multiple cancer subtypes. Therefore, the development of new agents and strategies which can overcome these limitations are crucial for patient health. To this end a novel class of polynuclear …

Role Of P53 Deficient Clonogenic Endothelial Cells In The Pathogenesis Of Pulmonary Hypertension, Aneel Roy Bhagwani

Theses and Dissertations

Pulmonary Artery Hypertension (PAH) is a progressive disorder of the small vessels of the pulmonary vasculature. It is characterized by occlusive vascular remodeling leading to right heart failure and ultimately death. PAH pathogenesis involves a multifactorial etiology leading to formation of occlusive lesions in small (preacinary) pulmonary arteries. These lesions contain hyper-proliferative, apoptosis resistant endothelial cells (ECs), smooth muscle cells and fibroblasts. ECs play a major role in the development of PAH. These ECs in vascular lesions are primitive and express progenitor cell markers, including CD117 (c-kit).

We have isolated clonally expanded, c-kit+ ECs from the lungs of Green Fluorescent …

An Exploration Of Teacher Residents’ Perception Of Culture And Their Use Of Culturally Responsive Pedagogy, Jodi Larson

Theses and Dissertations

Urban teacher residency (UTR) programs place residents in urban schools labeled “hard-to-staff” or “under-resourced.” Enrollment in residency schools tends to be majority Brown or Black students from various cultures. Teacher residents are from diverse backgrounds and races who have a commitment to teach in Title 1 schools with the support of a residency program that coaches them how to teach using culturally relevant pedagogy. Their journeys are unique from typical student teaching experiences because they co-teach with an experienced teacher for a full school year while attending university classes on pedagogy and theory. This qualitative case study followed seven elementary …

Modeling Substance Use And Mental Disorder Comorbidity Using Latent Variable And Network Approaches, Courtney T. Blondino

Theses and Dissertations

Introduction. Substance use disorder (SUD) is a common condition that affects millions of Americans. Addressing SUD has been complicated by comorbid mental disorders and co-occurring substance use. Consequently, detailing and addressing SUD and comorbid SUD represent an important goal to improve the health of Americans.

Objective. The research goal of this dissertation was to characterize the comorbidity between substance use, including tobacco use, and mental disorder symptoms measured as negative affect and externalizing symptoms in a population-based sample using latent variable and network approaches.

Methods. Waves 1 – 3 from the Population Assessment of Tobacco and Health Study were used. …

Single-Molecule Investigation Of I-Motif Folding And Dynamics In Bioinspired Dna Platforms, Anoja Megalathan

Theses and Dissertations

Although the canonical right-handed B-DNA is the predominant form of DNA in cells, DNA can adopt other secondary structures such as hairpins, G-quadruplexes (G4), and intercalated motifs (i-motif). These secondary structures are typically formed in the regions with repeat sequences. Among many secondary structures DNA can adopt, G-quadruplexes and i-motifs (tetraplex structures formed in the G-rich and C-rich sequences, respectively) caught significant research interest in recent years due to the prevalence of G-rich and C-rich sequences in the human genome. While G-quadruplexes are extensively studied, little is known about i-motifs – especially their formation and stability under cellular environments. For …

Leading In Crooked Rooms: Race, Gender, Culture And Black Women's Leadership Skills And Practices, Portia Newman

Theses and Dissertations

The literature on Black women leaders, where it exists, focuses on the barriers to Black women becoming leaders or being fully empowered when in leadership positions. However, to understand the leadership identity of Black women, and perhaps help to explain the absence of Black women in formal leadership spaces, means to examine the influence of race, gender, and culture on leadership behavior, as well as the setting in which leadership exists. This qualitative grounded theory study explored the leadership skills and practices of 15 senior-level cross sector Black women leaders. The data was collected in two phases: 1) a leadership …

Phenotypic Characterization Of Table Mountain (Pinus Pungens) And Pitch Pine (Pinus Rigida) Hybrids Along An Elevational Gradient In The Blue Ridge Mountains, Virginia, Alexander L. Brown

Theses and Dissertations

Hybridization has played a long-standing role in the evolution of both plant and animal species and allows for the sharing of genetic information between lineages. Here, potential hybridization of a species endemic to the Appalachian Mountains, Table Mountain pine (Pinus pungens), and pitch pine (Pinus rigida) was investigated along an elevational gradient, through the use of phenotypic measurements: cone length, cone width, and needle length. Phenotypes were used to identify hybrids in a three-tiered elevational sampling method at two sites in Shenandoah National Park with the use of linear discriminant analysis. It was found that hybridization …

Articulating The Heart Of Darkness: A Psychometric And Behavioral Analysis Of The Relationship Between Psychopathy And Sadism, Emily Lasko

Theses and Dissertations

Psychopathy and sadism, personality constructs largely characterized by antagonistic tendencies, share several similar traits and behaviors such as cruelty, callousness, and antisocial behavior. Due to this overlap, it remains unclear whether sadism is simply a facet of psychopathy, or they represent distinct but related constructs. The degree of overlap and distinction between these traits has yet to be empirically and thoroughly examined; therefore, the present project had two overarching interconnected aims: 1) Investigate the degree of psychometric overlap between psychopathy and sadism, and 2) examine potential behavioral distinctions between psychopathy and sadism. In Study 1, participants completed an online battery …

Grief, Loss, And Climate Change: Validation Of A Solastalgia Scale, Claire Luce

Theses and Dissertations

Climate change has been identified as a defining issue of this century (United Nations, n.d.). Climate change impacts human wellbeing including mental health. While much research has focused on the way that the effects of climate change cause increases in common mental disorders, mental health is not just the absence of these disorders (World Health Organization, 2014). Non-pathologized mental health responses to climate change, such as the grief and loss that results from climate change impacts, are a growing consideration for researchers. Solastalgia, or the distress experienced in the absence of the solace once provided by the environment in the …

Inclusive Academic Education & Vocationally-Oriented Transition Predictors’ Association With Post-Secondary Outcomes Of Youth With Intellectual And Developmental Disabilities, Joshua P. Taylor

Theses and Dissertations

Despite efforts through legislation to increase the engagement of individuals with intellectual and developmental disabilities (IDD) in competitive integrated employment (CIE) and post-secondary education, outcomes remain poor. However, recent policy has emphasized CIE as a preferred outcome and created new opportunities to engage individuals with IDD in post-secondary education. Likewise, research into the transition of youth with disabilities has revealed several predictors of post-school success including inclusive education and a variety of vocationally-oriented experiences. Previous research had not determined whether students with IDD received both inclusive academic education and vocational transition experiences or how these predictors might interact. The purpose …

Western Clinicians’ Diagnostic Accuracy Of Culture-Bound Syndromes, Lisa Y. Chung

Theses and Dissertations

Culture-bound syndromes are of increasing importance in today’s more diverse world. The current study measured the ability of clinicians trained in a western setting to accurately diagnose culture-bound syndromes from cultures outside of their background. Eight-four clinicians were recruited through the American Psychological Association (APA) membership directory. All recruited clinicians were asked to read three vignettes. In two vignettes a patient was suffering from either Hwabyung or Ataque de Nervios and the third vignette represented a control GAD vignette. The clinicians were asked to diagnose the patient in the vignette, to explain what information informed their diagnosis, to complete two …

Tya And Educational Outreach In Higher Education: An Asset To Undergraduates And Their Community, Emily J. Mattison

Theses and Dissertations

Undergraduate students pursuing a career in theatre are at the beginning of their life-long training and understanding and appreciation for the art. Performing in a Theatre for Young Audiences (TYA) touring production alongside the responsibility of crafting educational outreach opportunities provides the students with a unique chance to comprehend the art they have chosen to devote their lives to. This paper details the value of offering a course I crafted entitled “TYA Educational Outreach”, for both the undergraduates enrolled and the community they would be reaching. While undergraduates develop an understanding of the impact theatre can have on an individual …

Effects Of Buprenorphine Treatment On Myelin Following Traumatic Brain Injury In A Rat Model, Jane Ryu

Theses and Dissertations

Traumatic brain injury (TBI) is a common phenomenon, accounting for significant cost and adverse health effects. While there is information about focal pathologies following TBI, knowledge of more diffuse processes is lacking, particularly regarding how analgesics affect this pathology. As Buprenorphine (Bup) is the most commonly used analgesic in experimental TBI models, the current study investigated the effects of the opioid analgesic Buprenorphine-sustained release-Lab (Bup-SR-Lab) on physiology and myelin alterations at 1d and 4w following central fluid percussion injury (cFPI) in adult male rats. Microscopic assessments were performed at 1 day and 4w post-injury. Myelin pathology was assessed by evaluating …

Trauma Prevention & Best Practices In Performance Classrooms, Laine D. Wagner

Theses and Dissertations

Abstract

This thesis has been constructed to create a trauma-informed teaching method to be used within performance classrooms at the college level. The first chapter starts by defining trauma and walking the reader through the neuroscience behind trauma. Next, the code of ethics created by the National Educational Association is examined and a definition for best practices within the classroom is outlined. Finally, this chapter concludes with a definition of emotional abuse that brings all the concepts together and explains how they are interlaced.

The next chapter is dedicated to learning more about the percentage of actors who have experienced …

Heavy Hold: A Physical Score, Alexandra Velozo

Theses and Dissertations

This document is a collection of essays, stories, and fictional interviews that are in conversation with my performance, teaching, and sculpture practice. My research and work considers chronic illness, disability, the historic cultural connection between swamplands and illness, the medical industrial complex, medical theater, the medical gaze, disabled performers, metatactile space, sensory learning, and access.