Digital Commons Network^™

Judicial Independence In Pakistan: A Case Study Of Lawyers’ Movement, 2007-2009, Shabbir Ahmad Khan

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study focuses on a social movement, the Lawyers’ Moment 2007-2009 of Pakistan, a transitioning democracy, which brought vast changes in its judicial system, especially in terms of its judicial independence. There are three main research questions in this study: 1) the status of judicial independence before the Lawyers’ Movement; 2) was judicial independence a major goal in the Lawyers’ Movement? and 3) did the Lawyers’ Movement alter the status of judicial independence? The research methodology used to explore the answers to these questions also has three main sources: 1) the literature which explains some areas of scholarship in social …

Alcohol Consumption And The Risk Of Gastric Intestinal Metaplasia In A Us Veterans Population, Hudson M Holmes, Andre G Jove, Mimi C Tan, Hashem B El-Serag, Aaron P Thrift

Faculty, Staff and Students Publications

BACKGROUND: Chronic alcohol use is a risk factor for non-cardia gastric adenocarcinoma. However, it is less well understood whether alcohol use is a risk factor for premalignant mucosal changes, namely gastric intestinal metaplasia. We examined the association between various parameters of alcohol use and risk of gastric intestinal metaplasia.

METHODS: We used data from 2084 participants (including 403 with gastric intestinal metaplasia) recruited between February 2008-August 2013 into a cross-sectional study at the Michael E. DeBakey Veterans Affairs Medical Center in Houston, Texas. All participants underwent a study upper endoscopy with systematic gastric mapping biopsies. Cases had intestinal metaplasia on …

Mitochondrial Regulation Of Diabetic Kidney Disease, Daniel L Galvan, Koki Mise, Farhad R Danesh

Faculty, Staff and Students Publications

The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are poorly understood. Diabetic kidney cells exhibit a cascade of mitochondrial dysfunction ranging from changes in mitochondrial morphology to significant alterations in mitochondrial biogenesis, biosynthetic, bioenergetics and production of reactive oxygen species (ROS). How these changes individually or in aggregate contribute to progression of DKD remain to be fully elucidated. Nevertheless, because of the remarkable progress in our basic understanding of the role of mitochondrial biology and its dysfunction in DKD, there is great excitement …

Long Noncoding Rnas And Their Therapeutic Promise In Diabetic Nephropathy, Juan D Coellar, Jianyin Long, Farhad R Danesh

Faculty, Staff and Students Publications

Recent advances in large-scale RNA sequencing and genome-wide profiling projects have unraveled a heterogeneous group of RNAs, collectively known as long noncoding RNAs (lncRNAs), which play central roles in many diverse biological processes. Importantly, an association between aberrant expression of lncRNAs and diverse human pathologies has been reported, including in a variety of kidney diseases. These observations have raised the possibility that lncRNAs may represent unexploited potential therapeutic targets for kidney diseases. Several important questions regarding the functionality of lncRNAs and their impact in kidney diseases, however, remain to be carefully addressed. Here, we provide an overview of the main …

Genomic Mapping Of Dna-Repair Reaction Intermediates In Living Cells With Engineered Dna Structure-Trap Proteins, Jingjing Liu, Qian Mei, Sadeieh Nimer, Devon M Fitzgerald, Susan M Rosenberg

Faculty, Staff and Students Publications

Diverse DNA structures occur as reaction intermediates in various DNA-damage and -repair mechanisms, most of which results from replication stress. We harness the power of proteins evolutionarily optimized to bind and "trap" specific DNA reaction-intermediate structures, to quantify the structures, and discern the mechanisms of their occurrence in cells. The engineered proteins also allow genomic mapping of sites at which specific DNA structures occur preferentially, using a structure-trapping protein and ChIP-seq- or Cut-and-Tag-like methods. Genome-wide identification of sites with recurrent DNA-damage intermediates has illuminated mechanisms implicated in genome instability, replication stress, and chromosome fragility. Here, we describe X-seq, for identifying …

Small-Molecule Inhibitor Of Af9/Enl-Dot1l/Af4/Aff4 Interactions Suppresses Malignant Gene Expression And Tumor Grow, Fangrui Wu, Shenyou Nie, Yuan Yao, Tong Huo, Xin Li, Xiaowei Wu, Jidong Zhao, Yi-Lun Lin, Yinjie Zhang, Qianxing Mo, Yongcheng Song

Faculty, Staff and Students Publications

Chromosome translocations involving mixed lineage leukemia (MLL) gene cause acute leukemia with a poor prognosis. MLL is frequently fused with transcription cofactors AF4 (~35%), AF9 (25%) or its paralog ENL (10%). The AHD domain of AF9/ENL binds to AF4, its paralog AFF4, or histone-H3 lysine-79 (H3K79) methyltransferase DOT1L. Formation of AF9/ENL/AF4/AFF4-containing super elongation complexes (SEC) and the catalytic activity of DOT1L are essential for MLL-rearranged leukemia. Protein-protein interactions (PPI) between AF9/ENL and DOT1L/AF4/AFF4 are therefore a potential drug target.

Methods: Compound screening followed by medicinal chemistry was used to find inhibitors of such PPIs, which were examined for their biological …

The E3 Ligase Traf4 Promotes Igf Signaling By Mediating Atypical Ubiquitination Of Irs-1, Wenjuan Yu, Ramesh Singh, Zhao Wang, Bert W O'Malley, Ping Yi

Faculty, Staff and Students Publications

Insulin-like growth factor (IGF) is a potent mitogen that activates the IGF receptor (IGFR)/insulin receptor substrate (IRS) axis, thus stimulating growth in normal cells and uncontrolled cell proliferation in cancer. Posttranslational modifications of IRS such as ubiquitination tightly control IGF signaling, and we previously identified IRS-1 as a potential substrate for the E3 ubiquitin ligase TRAF4 using an unbiased screen. Here we provide evidence that TRAF4-mediated ubiquitination of IRS-1 is physiologically relevant and crucial for IGF signal transduction. Through site-directed mutagenesis we found that TRAF4 promotes an atypical K29-linked ubiquitination at the C-terminal end of IRS-1. Its depletion abolishes AKT …

Enhancing Glucose Metabolism Via Gluconeogenesis Is Therapeutic In A Zebrafish Model Of Dravet Syndrome, Rajeswari Banerji, Christopher Huynh, Francisco Figueroa, Matthew T Dinday, Scott C Baraban, Manisha Patel

Faculty, Staff and Students Publications

Energy-producing pathways are novel therapeutic targets for the treatment of neurodevelopmental disorders. Here, we focussed on correcting metabolic defects in a catastrophic paediatric epilepsy, Dravet syndrome which is caused by mutations in sodium channel NaV1.1 gene, SCN1A. We utilized a translatable zebrafish model of Dravet syndrome (scn1lab) which exhibits key characteristics of patients with Dravet syndrome and shows metabolic deficits accompanied by down-regulation of gluconeogenesis genes, pck1 and pck2. Using a metabolism-based small library screen, we identified compounds that increased gluconeogenesis via up-regulation of pck1 gene expression in scn1lab larvae. Treatment with PK11195, a pck1 activator …

Lawton's Bloodhounds: Indigenous Recruits In The Service Of The United States Army In The Philippine American War, 1899-1902, Carole Irene Butcher

History, Philosophy, and Religious Studies

Following the Spanish American War, the United States became embroiled in a guerrilla war with Filipino insurgents who had sought independence from Spain. They objected to the purchase of the Philippine Islands by the United States. The result was the Philippine American War, 1899-1902. At that time, the United States Army had no written doctrine and provided no formal training in the prosecution of a guerrilla war. This study traces American success in the Philippines to reliance on a proven technique utilized by colonial armies of the period: recruitment of native allies. American General Henry Ware Lawton served in the …

Covid-19 Vaccine Uptake Through The Lived Experiences Of Health Care Personnel: Policy And Legal Considerations, Rachel Gur-Arie, Zackary Berger, Dorit Rubinstein Reiss

Faculty Scholarship

Purpose: To investigate whether coronavirus disease 2019 (COVID-19) vaccination campaigns targeted at health care personnel (HCP) in the United States have addressed the lived experiences of HCP on the frontlines of the COVID-19 pandemic and to analyze policy and legal considerations for improving COVID-19 vaccine uptake among HCP. Methods: We conducted a literature and policy review to explore the lived experiences of different occupational groups of HCP on the frontlines of the COVID-19 pandemic—physicians, nurses, trainees, and nonclinical essential workers—in relation to ongoing COVID-19 vaccination campaigns. Finally, we discuss policy and legal considerations to improve the state of HCP COVID-19 …

Speaking Music: A Historical Study Of Edwin Gordon's Music Learning Theory, David M. Alfred

Graduate Theses, Dissertations, and Problem Reports (ETD)

Music Learning Theory, conceived, researched, and developed by Dr. Edwin Elias Gordan, has been on the periphery of music education for decades and is the only extant comprehensive theoretical framework that fully addresses the development of music literacy from early childhood through maturity. The concurrent research gap suggests that a Fordist approach may exist throughout music education – one that insists upon behavioral goals, direct instruction, and educational, artistic, and ideological exclusivity. This historical study elucidates Gordan’s work in order to understand the stages and processes that are like spokes of a wheel between his idea of audiation at the …

Vaccine Skeptical Mothers In The Upper Midwest And Their Kitchen-Based Care Practices, Kimberly Allison Haarstick

Sociology and Anthropology

While many Americans view vaccination and medical intervention as benefits to society and for the greater good, vaccine skeptical mothers not only reject vaccinations but most biomedical interventions as well. In place of biomedical interactions vaccine skeptical mothers here focused on daily care practices centered around a healthy diet and eating whole foods. Further, they then create alternative forms of care that are founded in their kitchens and based on their own expertise as mothers, rather than with the expertise of biomedical experts. Based on nineteen months of in-person and virtual ethnographic research in a mid-size Upper Midwestern city in …

Assessing Burnout And Resiliency Among Nurse Practitioners, Kezia Renea Sogard

Nursing

The topic of burnout among medical doctors (MDs) has depicted a strong correlation to MD education and career with burnout, ultimately causing negative psychological and physical outcomes. Research has shown that resilience is a concept that has often been associated with MD ability to respond to stress and decrease burnout. Beyond MDs, the population of nurse practitioners (NPs) has been minimally researched in relation to burnout. NPs are at heightened risk of burnout, comparable to MDs, in relation to rigorous education requirements, large workloads, long work hours, rising demands of documentation, and increased technological advances within health care. The purpose …

Enhancing Health Professionals' Cultural Competence Of Gender And Sexual Minority Health, Megan Beth Thiel

Nursing

The lesbian, gay, bisexual, and transgender (LGBT) community continues to experience worse health outcomes than their heterosexual counterparts. Inequities in health care include low health insurance rates, high rates of stress due to systemic discrimination and stigma, and a lack of cultural competency in the health care system. Gender and sexual minority (GSM) people are at higher risk of mental health disorders, sexually transmitted infections (STIs) and human immunodeficiency virus (HIV), substance use and abuse, cancer, suicide, and other disorders/diseases. A lack of cultural competency in health care systems perpetuates these health disparities and inequities in care that burden the …

Screening Adolescent Females For Eating Disorders In Primary Care, Brooke Marie Thom

Nursing

In recent decades, there has been an increased focus on the idealization of thinness and the pressure and expectancy to be thin, which contributes to a rising number of individuals that experience severe body dissatisfaction and body distortion, and in turn, eating disorders. Eating disorders are one of the most common chronic conditions within the youth population, approximately 13% of the adolescent youth population will suffer from at least one eating disorder by age 20, and a majority of those affected will be female. Rural health care providers encounter many health care disadvantages when detecting and treating eating disorders including …

Emergency Care Skills Preparedness Of Rural Nurse Practitioners, Erika Marie Stueve

Nursing

In the rural setting, emergencies present as high stress situations and can have significant consequences for the patient, family, provider, and hospital staff involved. Many rural hospitals rely heavily on nurse practitioners (NPs) to provide care for the community as well as covering the emergency department. Thorough education in emergency training and skill competencies are essential when taking on the role of a provider in rural facilities and critical access hospitals. When a critically ill patient presents to a rural emergency department, an NP may be the only provider available, therefore, having increased education and continued sustainment of emergency care …

C.O.P.E. Influence On Resiliency And Self-Efficacy In A Rural North Dakota School (Creating Opportunities For Personal Empowerment), Ariel Kristine Schwarzrock

Nursing

One in three teens is estimated to experience an anxiety disorder between 13 to 18 years of age. Developed mental health burdens in adolescents can go undetected and untreated. About 50% of those with mental health disorders noted in adulthood started by age 14 years. Therefore, adolescence may be a critical phase for developing positive coping mechanisms and one where nurse practitioners can proactively impact outcomes. Cognitive behavioral therapy (CBT) is an evidence-based strategy effective in decreasing mental health burden. Creating Opportunities for Personal Empowerment (COPE) is a program created for pediatrics using CBT strategies to manage emotions and promote …

Bad Role Models? American Influence On Israeli Criminal Justice Policy, Hadar Aviram

Faculty Scholarship

In this Article I rely on the public policy concept of "policy transfer" to examine the impact of U.S. legislation, litigation, and politics on the Israeli criminal justice landscape. The Article identifies four eras: 1. The Great Light from the West - the ascent of U.S. criminal justice as British influence fades; 2. The Decade of Rights - a misperception of America as a paragon of criminal justice rights and protections that results in influences on Israeli jurisprudence; 3. The Law-and-Order Enchantment Period - a time at which Israeli scholars and policymakers import punitive trends from the U.S., particularly in …

Exploring The Effects Of Interleaving On Mind-Wandering, Alyssa Lynn Miller

Psychology

Research has shown that interleaving (a study technique where two topics are practiced in an alternating fashion) enhances learning and memory. However, it is unclear whether interleaving impacts the frequency of mind-wandering. The current research explores the extent to which interleaving reduces mind-wandering using a between-subjects design. Participants completed the experiment remotely and learned 40 bird images from 8 distinct families. Bird images were presented in pairs from two different families (e.g., interleaved) or individually from one family (e.g., blocked). After a brief distractor task, participants completed a final classification test. Participants also completed a post-assessment questionnaire regarding the level …

Pulling Back The Curtain: A Student Collaborative Case Study Of Equity Issues In Colorado’S School Finance System, Amy Jo Schwartz

Electronic Theses and Dissertations

After the Great Recession, a seven percent decrease in funding ended decades of academic growth and further widened the achievement gap between White and Black students (Jackson et al., 2020). Colorado’s school-finance system is particularly distorted and inequitable because of a series of tax-limiting policies which, combined, have led Colorado to become one of the lowest-funded per pupil states in the country (Resnick et al., 2015). The purpose of this study is to describe the policymaking context, as it relates to equity within Colorado’s school-finance system and explore policy alternatives to improve equity within the system. The study was designed …

Understanding Programmed Cell Death Pathways By Characterizing Barley Disease Lesion Mimic Mutants, Wail Alsolami

Plant Pathology

Programmed cell death (PCD) in plants refers to rapid and localized cell death that occurs as a result of regular biological processes, or in response to infection or injury. Understanding the molecular mechanisms of PCD will fill key knowledge gaps in regard to plant development or resistance mechanisms. Upon pathogen invasion salicylic acid and reactive oxygen intermediate (ROI) signaling responses are triggered that contribute to the PCD outcome. Substantial research efforts have been conducted to identify genes involved in these PCD pathways including the generation and characterization of disease lesion mimic mutants (DLMMs) that spontaneously express PCD and necrotic lesions …

Past Flooding Events And A 400+ Year Ring-Width Chronology Of Bur Oak Along The Red River In North Dakota And Minnesota, Matthew Bruce Schlauderaff

Natural Resources Management

A paleoflood record of the United States portion of the Red River of the North was created utilizing rings of bur oak (Quercus macrocarpa Michx.). Emphasis was placed on the flood of 1826. Samples were collected from standing trees and historic log buildings. All samples were observed for flood rings and measurements were taken for 90% of physical samples. Flood rings for 1826 were disproportionately found at one specific site near Shelly, MN. Ring width measurements were taken from 179 physical samples and combined into a ring-width chronology spanning from modern times back to 1601. The results suggest that the …

Kv13 Channel Up-Regulation In Peripheral Blood T Lymphocytes Of Patients With Multiple Sclerosis, Ioannis Markakis, Ioannis Charitakis, Christine Beeton, Melpomeni Galani, Elpida Repousi, Stella Aggeloglou, Petros P Sfikakis, Michael W Pennington, K George Chandy, Cornelia Poulopoulou

Faculty, Staff and Students Publications

Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation. It is noteworthy that an accumulating body of in vivo and in vitro evidence links these channels to multiple sclerosis pathophysiology. Here we studied the electrophysiological properties and the transcriptional and translational expression of T lymphocyte Kv1.3 channels in multiple sclerosis, by combining patch clamp recordings, reverse transcription polymerase chain reaction and flow cytometry on freshly isolated peripheral blood T lymphocytes from two patient cohorts with multiple sclerosis, as well as from healthy …

Getting Connected: Exploring The Role Of Sustainability Labels In Tourism Marketing Communications, Elvira Kizilova

Graduate Theses, Dissertations, and Problem Reports (ETD)

While sustainability has become an important brand differentiator in many industries, current research suggests that tourism businesses rarely use sustainability labels in their communications, e.g., on their websites or other types of advertisements.

This dissertation examines the role of sustainability labels in increasing consumer preferences for sustainable travel destinations. Drawing on social exchange theory and anthropomorphism framework, we propose that sustainability labels increase consumer visit intentions, willingness to recommend a destination to someone else, and willingness to pay price premium for the sustainable offer. These effects are mediated by perception of goal congruence and connectedness with a destination. We further …

The Effects Of Dementia Knowledge On Dementia Worry, Attitudes, Social Comfort, Empathic Concern, And Personal Distress, Alexandria Rose Ebert

Graduate Theses, Dissertations, and Problem Reports (ETD)

The present study examined the effects of different types of dementia knowledge on attitudes and affective reactions towards persons with dementia. Work has demonstrated that individuals with higher levels of personhood-based knowledge have lower levels of personal dementia fear and higher levels of social comfort. However, to our knowledge, work has not examined dementia attitudes more broadly or differentiated causal relations among different forms of dementia knowledge and attitude outcomes. Participants (N = 334) aged 19-78 (M = 44.53, SD = 16.57) were randomized into one of five experimental conditions: (1) biomedical-knowledge (BK; read biological and medical facts about …

Decision-Making Involvement, Social Support For Healthy Behaviors, And Nutritional Adherence In Adolescents With Cystic Fibrosis, Jennifer Kelleher

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Adolescents with cystic fibrosis (awCF) exhibit suboptimal adherence to dietary and enzyme recommendations despite the fact that eating a high calorie diet with enzymes significantly improves lung functioning. Furthermore, during adolescence teens and their caregivers begin to negotiate treatment responsibility, shifting treatment tasks to the youth. As such, it is important to understand which aspects of the complex decision-making process (e.g., expressing an opinion, asking for information from parents/adults, making joint decisions with parents) relate to better dietary adherence in adolescents with CF and how parents can best support these healthy behaviors. Thus, this study aimed to identify how …

Lrrtm4 Is A Member Of The Transsynaptic Complex Between Rod Photoreceptors And Bipolar Cells, Melina A Agosto, Theodore G Wensel

Faculty, Staff and Students Publications

Leucine rich repeat transmembrane (LRRTM) proteins are synaptic adhesion molecules with roles in synapse formation and signaling. LRRTM4 transcripts were previously shown to be enriched in rod bipolar cells (BCs), secondary neurons of the retina that form synapses with rod photoreceptors. Using two different antibodies, LRRTM4 was found to reside primarily at rod BC dendritic tips, where it colocalized with the transduction channel protein, TRPM1. LRRTM4 was not detected at dendritic tips of ON-cone BCs. Following somatic knockout of LRRTM4 in BCs by subretinal injection and electroporation of CRISPR/Cas9, LRRTM4 was abolished or reduced in the dendritic tips of transfected …

Understanding The Public Sentiment And Discourse On Covid-19 Vaccine, Kruttika Sutrave, Rajesh Godasu, Jun Liu

Research & Publications

The novel Coronavirus disease has negatively impacted human lives in various aspects leading to the global health crisis and economic fallout. The availability of vaccines in the U.S. is a relief. However, many people are not in favor of the COVID-19 vaccine. The study aimed to identify the emotions and themes of discourse related to the COVID-19 vaccine posted on Twitter. Sentiment analysis and topic modeling techniques were employed to discover the sentiment and prevalent themes. The findings suggest that overall, the public has positive opinions towards the vaccine. Those people that show positive opinions appreciate the efforts of leadership, …

Ketamine: Neuroprotective Or Neurotoxic?, Divya Choudhury, Anita E Autry, Kimberley F Tolias, Vaishnav Krishnan

Faculty, Staff and Students Publications

Ketamine, a non-competitive N-methyl-D-aspartate receptor (NMDAR) antagonist, has been employed clinically as an intravenous anesthetic since the 1970s. More recently, ketamine has received attention for its rapid antidepressant effects and is actively being explored as a treatment for a wide range of neuropsychiatric syndromes. In model systems, ketamine appears to display a combination of neurotoxic and neuroprotective properties that are context dependent. At anesthetic doses applied during neurodevelopmental windows, ketamine contributes to inflammation, autophagy, apoptosis, and enhances levels of reactive oxygen species. At the same time, subanesthetic dose ketamine is a powerful activator of multiple parallel neurotrophic signaling cascades …

The Effect Of Climate Change On The Predatory Success Of Sharks, Melina Kuerschner

Natural Resources Management

This literature overview focuses on how shark species, are faring with the anthropogenically induced climatic changes. The ocean is drastically affected by this, which has major implications on the aquatic life. Some effects include increasing temperature, carbon dioxide and acidity levels. This has led to shifts in the predatory success in sharks, which will only increase in severity as climate change intensifies, because changes in climate induce other changes in most aspects of the shark’s life. These can be grouped into three categories: shifts in body functions, behaviors and habitat. Some changes in body function include difficulty integrating sensory cues …