Digital Commons Network^™

5-Ht Recruits Distinct Neurocircuits To Inhibit Hunger-Driven And Non-Hunger-Driven Feeding, Yanlin He, Xing Cai, Hailan Liu, Krisitine M Conde, Pingwen Xu, Yongxiang Li, Chunmei Wang, Meng Yu, Yang He, Hesong Liu, Chen Liang, Tingting Yang, Yongjie Yang, Kaifan Yu, Julia Wang, Rong Zheng, Feng Liu, Zheng Sun, Lora Heisler, Qi Wu, Qingchun Tong, Canjun Zhu, Gang Shu, Yong Xu

Children’s Nutrition Research Center Staff Publications

Obesity is primarily a consequence of consuming calories beyond energetic requirements, but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons in the dorsal Raphe nucleus (5-HTDRN) regulate different types of feeding behavior, such as eating to cope with hunger or for pleasure. Here, we observed that activation of 5-HTDRN to hypothalamic arcuate nucleus (5-HTDRN → ARH) projections inhibits food intake driven by hunger via actions at ARH 5-HT2C and 5-HT1B receptors, whereas activation of 5-HTDRN to ventral tegmental area (5-HTDRN → VTA) projections inhibits non-hunger-driven feeding via actions at 5-HT2C receptors. Further, hunger-driven feeding gradually activates ARH-projecting 5-HTDRN …

Intermittent Bolus Feeding Does Not Enhance Protein Synthesis, Myonuclear Accretion, Or Lean Growth More Than Continuous Feeding In A Premature Piglet Model, Marko Rudar, Jane K Naberhuis, Agus Suryawan, Hanh V Nguyen, Barbara Stoll, Candace C Style, Mariatu A Verla, Oluyinka O Olutoye, Douglas G Burrin, Marta L Fiorotto, Teresa A Davis

Children’s Nutrition Research Center Staff Publications

Optimizing enteral nutrition for premature infants may help mitigate extrauterine growth restriction and adverse chronic health outcomes. Previously, we showed in neonatal pigs born at term that lean growth is enhanced by intermittent bolus compared with continuous feeding. The objective was to determine if prematurity impacts how body composition, muscle protein synthesis, and myonuclear accretion respond to feeding modality. Following preterm delivery, pigs were fed equivalent amounts of formula delivered either as intermittent boluses (INT; n = 30) or continuously (CONT; n = 14) for 21 days. Body composition was measured by dual-energy X-ray absorptiometry (DXA) and muscle growth was …

Dash Diet Adherence And Cognitive Function: Multi-Ethnic Study Of Atherosclerosis, George D Daniel, Haiying Chen, Alain G Bertoni, Stephen R Rapp, Annette L Fitzpatrick, José A Luchsinger, Alexis C Wood, Timothy M Hughes, Gregory L Burke, Kathleen M Hayden

Children’s Nutrition Research Center Staff Publications

Background and aims: The Adherence to the Dietary Approaches to Stop Hypertension (DASH) diet has been associated with better cognitive function in studies of predominantly White participants; few studies have examined this association in diverse cohorts. Our objective was to examine the association between the DASH diet and cognitive function in the diverse Multi-Ethnic Study of Atherosclerosis (MESA) cohort.

Methods: Among 4169 MESA participants, we evaluated prospectively, the association between DASH diet adherence and cognitive function. Participants completed a food frequency questionnaire at baseline (2000-2002) and cognitive function was assessed using the Cognitive Abilities Screening Instrument (CASI), Digit Symbol Coding …

Pcor Partnership Atlas, Wesley D. Peck, Earl P. Battle, Kari Suedel, Kyle A. Glazewski, Kevin C. Connors, James A. Sorensen, John A. Hamling, Charles D. Gorecki, Edward N. Steadman, John A. Harju

EERC Maps and Infographics

The Plains CO₂ Reduction (PCOR) Partnership Atlas provides a regional profile of CO₂ sources and potential storage locations across the PCOR Partnership region. The sixth edition provides an up-to-date look at PCOR Partnership initiative activities, including additional regional characterization and updates on commercial projects. Additional background information on carbon capture, utilization, and storage (CCUS) is included to give a better understanding of how CCUS addresses concerns about climate change while allowing future energy needs to be met.

The Year Of Brood Viii, Jona L. Pederson

Greenway Press Chapbooks

No abstract provided.

Extending The Argument: A Case Study Exploring How To Decay Consumer Grudges In A Social Media World, Onnolee Nordstrom, Laura Egan

Librarian Publications

We study the process involved in diminishing consumer grudges against an industry. Through a qualitative case study of an organization tasked with changing consumer’s negative perceptions and beliefs about the Canadian agriculture industry, we uncover how the process of decaying grudges involves presenting information, creating credibile sources, and building positive affect. Our findings extend Thota and Wright’s (2006) grudgeholding decay framework.

Hierarchical Control Of Multi-Agent Reinforcement Learning Team In Real-Time Strategy (Rts) Games, Weigui Jair Zhou, Budhitama Subagdja, Ah-Hwee Tan, Darren Wee Sze Ong

Research Collection School Of Computing and Information Systems

Coordinated control of multi-agent teams is an important task in many real-time strategy (RTS) games. In most prior work, micromanagement is the commonly used strategy whereby individual agents operate independently and make their own combat decisions. On the other extreme, some employ a macromanagement strategy whereby all agents are controlled by a single decision model. In this paper, we propose a hierarchical command and control architecture, consisting of a single high-level and multiple low-level reinforcement learning agents operating in a dynamic environment. This hierarchical model enables the low-level unit agents to make individual decisions while taking commands from the high-level …

The Oakland Athletics Use Of Sabermetrics And The Rise Of Big Data Analytics In Business, Jacob Moorefield

Honors Theses

The Moneyball phenomenon revealed how Billy Beane, the Oakland Athletics general manager utilized advanced data analytics; Sabermetrics, to statistically analyze the data in baseball which aims to quantify baseball players’ performances based on objective statistical measurements. As technology increases and big data becomes more accessible, sports organizations like the Oakland Athletics are illustrating how businesses, small and large, can use advanced analytics to promote growth. This research paper provides a meta-analysis on the results of large businesses using big data analytic techniques similar to Sabermetrics, to show the improvements in marketing, consumer outreach, revenue, and employee retention while questioning whether …

The Combined Influences Of Race, Sexuality, And Gender On Perceptions Of Sexual Harassment, Courtney House

Honors Theses

The current research examines the perceptions of sexual harassment based on the influence of the victim’s gender, and the race of both the victim and the perpetrator, and perceiver’s feminist beliefs. By using vignettes (a brief description of an event), we manipulated a) the gender of the victim (man or woman), b) the race of the victim (POC or white), and c) the race of the perpetrator (POC or white). Our hypotheses were as follows: a) vignettes depicting same-sex harassment will be less in line with the definition of sexual harassment; b) vignettes portraying the victim as a woman of …

“A Penny For Your Thoughts:” Developing An Adapted Stimulus Reward Association – Stroop Task To Assess The Impact Of Individual Difference Factors On Cognitive Control, Mia Melone

Honors Theses

Limited studies have examined the effect of feedback sensitivity and intrinsic motivation on cognitive performance. The present study serves as a pilot project for a study at the University of Tennessee at Chattanooga that examines the modulating role of external, monetary reward incentives and cognitive intrinsic motivation on cognitive control. For the present study, the relationship among cognitive performance outcomes (reaction time and accuracy) on an adapted Stimulus Reward Association Stroop Task will be explored. Two main hypotheses were tested in the present study: H1 Reaction time on congruent trials will be significantly faster than reaction time on incongruent trials. …

“Impresse Et Diligenter Correcte”: Johann Koelhoff The Elder’S Transmission Of Francesco Griffolini’S Latin Translation Of Chrysostom’S Homilies On John, Chris L. Nighman

History Faculty Publications

No abstract provided.

Recapture And Reuse Of Nitrogen And Phosphorus From Rendered Animal Materials To Enhance Nutrient Use Efficiency And Produce Quality In Agricultural Crop, Bhupinder Jatana

All Dissertations

The current fertilizer regime heavily relies on inorganic fertilizers to meet the crop nitrogen (N) and phosphorus (P) demand. However, the United States has a limited N production capacity, with 50% N demand met through imports. On the other hand, the nonrenewable natural reserves of P are being depleted at an unprecedented rate and are expected to be exhausted with in next 100 years. Additionally, high solubility/liability of the field applied inorganic fertilizers often results in lower nutrient use efficiency (NUE;

The MBM led to rapid N mineralization, with 35% of the applied N mineralized within the first five days …

Exploring The Impact Of Authentic Assessment On Sustainability Literacy Through Reflective And Action-Oriented Tasks: A Roundtable Podcast, Olivia Freeman, Deirdre Duffy, Alacoque Mcalpine, Ciara Nolan Dr, Cormac Mcmahon, Lucia Walsh

Irish Journal of Academic Practice

Business schools must engage in fundamental change to retain their legitimacy and position themselves as providers of solutions to urgent economic, social, and environmental crises. To this end, we need pedagogy that enables students to become sustainability literate graduates and thus develop appropriate knowledge, skills, and mind-sets. This roundtable discussion podcast comprises six colleagues engaged in conversation and reflection around a pedagogical initiative designed with the broad aim of enhancing sustainability literacy among business students using innovative digital tools as part of an authentic assessment strategy. The pedagogical approaches we discuss engage students with learning across several different modes and …

Computational Investigations Of The Photochemical Properties Of B12-Dependent Systems: From Solution To Enzymes., Megan Toda Mackintosh

Electronic Theses and Dissertations

The photochemical properties of the B₁₂ family of molecules (cobalamins = Cbls) have been known for many years yet only until the 21^st century have applications for the light-sensitivity of Cbls come to the surface. Photolabile Cbls can be used for the delivery of therapeutics with spatial and temporal control, in the generation of hydroxyl radicals, and in nature, as demonstrated in the catalytic cycle of coenzyme B₁₂-dependent photoreceptors. This dissertation describes the use of computational methods to explore the photochemical properties of Cbl systems including antivitamins B₁₂, a thiolato-cobalamin, and the coenzyme B …

Video Games And Their Potential As Literacy Tools, Jessica Reich

University Honors Program Senior Projects

Video games are an essential part of emergent popular culture, with millions playing games every day. With how popular gaming has become, it is logical to research its full potential as a literacy tool both inside and outside the classroom. This thesis contributes to the discussion of the importance and potential of video games as a literacy tool that can be utilized educationally and through gaming at home. This thesis includes a section for gaming definitions, a literature review on research on video games and their impact on education and literacy skill development, a discussion of video game narratives, and …

Estimating Smart Wi-Fi Thermostat-Enabled Thermal Comfort Control Savings For Any Residence, Abdulelah D. Alhamayani, Qiancheng Sun, Kevin Hallinan

Mechanical and Aerospace Engineering Faculty Publications

Nowadays, most indoor cooling control strategies are based solely on the dry-bulb temperature, which is not close to a guarantee of thermal comfort of occupants. Prior research has shown cooling energy savings from use of a thermal comfort control methodology ranging from 10 to 85%. The present research advances prior research to enable thermal comfort control in residential buildings using a smart Wi-Fi thermostat. "Fanger's Predicted Mean Vote model" is used to define thermal comfort. A machine learning model leveraging historical smart Wi-Fi thermostat data and outdoor temperature is trained to predict indoor temperature. A Long Short-Term-Memory neural network algorithm …

Hermeneutics Of Hate: How Martin Luther's Rhetorical Manipulation Of The Greek Bible Led To His Anti-Judaic Treatise On The Jews And Their Lies, Michael Parrish

Electronic Theses and Dissertations, 2020-2023

Though lauded as a Protestant hero, it is impossible to read Martin Luther's On the Jews and Their Lies and not think about the numerous acts of violence inspired by his commentary. Luther argues that his anti-Judaic treatise is simply reiterating the Greek Bible (the New Testament) and anyone who reads the Greek Bible would come to the same conclusion. This thesis argues that Luther adopted a hermeneutical Jew from theologians and the Greek Bible before him to create his own hermeneutics that demonized the European Jewish population with devastating consequence. Though much of the Greek Bible was part of …

(R1887) Inferring Trends Of Point Processes From Non-Iid Samples, Bruno Appolloni

Applications and Applied Mathematics: An International Journal (AAM)

We discuss unprecedented, albeit rudimentary, tools to infer the evolution of a point process where the available samples are both truncated and non independently drawn. To achieve this goal, we lay in an intermediate domain between probability models and fuzzy sets, still maintaining probabilistic features of the employed statistics as the reference KPI of the tools. The overall strategy is to frame the problem within the Algorithmic Inference framework and use a sort of kernel trick to distort the seeds of the observed variable so as to render them an iid sample of a random variable in a proper feature …

We're All Originalists Now… Or Are We?: Bostock's Misperceived Quest To Distinguish Title Vii's Meaning From The Public's Expectations, Steven Semeraro

Hofstra Law Review

Two principal tenets underlie originalism-textualism: First, judicial interpreters of a statute should not use modern values to supplant original meaning because the law should change only through democratic processes. Second, original meaning is limited to the intersubjective original understanding that a reasonable reader would draw from a statute’s text. Meaning does not include anyone’s extratextual subjective expectations about how a statute should apply.

The divided Bostock Court’s decision that Title VII prohibits sexual orientation and gender identity discrimination reveals a contradiction between originalism-textualisms dual tenets. The mid-1960s public’s expectations about how Title VII would apply to sexual orientation and gender …

4d Ex Vivo Crispr/Cas9 Whole-Genome Screen To Identify Genes Regulating Lung Cancer Metastasis, Alexandria Plumer

Dissertations and Theses (Open Access)

Metastatic lung cancer has a 5-year survival rate of 5%. Lung cancers tend to be asymptomatic until late stages, and almost 90% are not diagnosed until they are advanced. Metastases are very rare events, often initiated by a single cell from a primary tumor into a new niche at a distant location. Investigation of the early metastatic process is of urgent need for the development of early diagnostics and targeted therapeutics. We performed a proof-of-concept CRISPR/Cas9 whole genome knockout screen in the A549 lung adenocarcinoma cell line and utilized a novel ex vivo 4D lung metastasis model to find gene …

The Src- And Abl- Dependent Regulation Of Net1a In Breast Cancer, Ashabari Sprenger

Dissertations and Theses (Open Access)

The neuroepithelial cell transforming gene 1 (Net1) is a RhoA guanine nucleotide exchange factor that promotes cancer cell motility and metastasis. Two isoforms of Net1 exist, Net1 and Net1A, both of which are which sequestered in the nucleus in quiescent cells to prevent aberrant RhoA activation. Many cell motility stimuli drive cytosolic relocalization of Net1A, but mechanisms controlling this event are not fully understood. Here we demonstrate that EGF stimulates Src- and Abl1-dependent phosphorylation of Net1A to promote its cytosolic localization. We find that Abl1 efficiently phosphorylates Net1A on Y373, and that phenylalanine substitution of Y373 prevents Net1A cytosolic localization. …

Electronic Cigarettes’ Health Effects On Young Adults: An Honors Thesis, Miranda Yates

Senior Honors Theses

Hon Lik introduced e-cigarette use in 2003 as a “safe alternative” to smoking cigarettes. Unfortunately, this message has been misinterpreted to mean that e-cigarette use is “harmless”. Recent studies have linked e-cigarette use to adverse health effects involving injury to the heart and lungs. Cigarette smokers using e-cigarettes to quit smoking and reduce second-hand smoke are being exposed to unregulated and potentially harmful chemicals. Teens who may never have considered cigarette smoking have been led to believe that e-cigarette use is safe and non-addictive. However, most e-cigarettes contain nicotine and unsuspecting teens are becoming addicted to this “fun” behavior. This …

Perceptions Of Risk For Covid-19 Among Individuals With Chronic Diseases And Stakeholders In Central Appalachia, Manik Ahuja, Hadii M. Mamudu, Florence M. Weierbach, Karilynn Dowling-Mcclay, David W. Stewart, Manul Awasthi, Timir K. Paul

ETSU Faculty Works

Coronavirus disease 2019 (COVID-19) pandemic is rapidly evolving and is a serious public health threat worldwide. Timely and effective control of the pandemic is highly dependent on preventive approaches. Perception of risk is a major determinant of health behavior. The current study explores the association between actual risk and perceived risk for one’s self, family/friends and friends, and community. A questionnaire was administered to participants in Central Appalachia (n = 102). The actual risk was based on the number of chronic conditions of the following conditions: hypertension, heart disease, cancer, diabetes, and chronic obstructive pulmonary disease. Participants were also queried …

Reconsidering The Foregone Conclusion Doctrine: Compelled Decryption And The Original Meaning Of Self-Incrimination, Norman Hobbie Jr.

The University of New Hampshire Law Review

The Self-Incrimination Clause of the Fifth Amendment prohibits the government from compelling an individual “to be a witness against himself.” The Supreme Court of the United States has long interpreted “witness” as “one who gives testimony.” Undoubtedly, this interpretation prevents the government from compelling a witness to take the stand and testify to his own demise. This interpretation also extends to the act of producing documents, giving rise to the so-called “act of production” doctrine. Yet if a court deems the testimonial value of the act minimal—in other words, not “sufficiently testimonial”—the government can compel production under the “foregone conclusion” …

Law And Sampling Theory, Jack Thorlin

The University of New Hampshire Law Review

Law involves a fundamental tradeoff, a sampling problem. In science, sampling problems emerge when trying to understand something complicated by considering discrete, manageable subsets of it—samples. When doing that, scientists must compromise between accuracy and resource-expenditure. Perfect accuracy requires infinite resources, such as a perfect digital image with infinite file size. Perfection being unattainable, scientists must decide what level of accuracy is best for any given case. Every kind of law, from parking regulations to criminal to high constitutional theory, is subject to the same dynamic.

Law’s sampling problem is the tradeoff between accurate representation of a community’s moral preferences …

In Vitro Fertilization, Fertility Frustrations, And The Lack Of Regulation, Delores V. Chichi

Hofstra Law Review

No abstract provided.

Constructivism In Choral Music Education: Supplemental Activities For The Traditional Choral Ensemble, Allison Renee Fojo

Graduate Thesis Collection

Constructivism in music education can help teachers and students alike better their educational experience by working as a collaborative team. In the choral classroom, constructivist teaching establishes the teacher as the facilitator of learning rather than the “teacher as conductor.” Teachers help foster the musical-thinking of the ensemble. Students learn and retain information when teachers can support learners’ understanding of musical ideas and work within the student’s zone of proximal development. Through the use of teacher-guided questioning, cognitive apprenticeship, informal music-making, CMP, problem-solving, and Understanding by Design, students become active participants. Included are supplemental activities for the traditional choir classroom …

Smart Metering Communication Protocols And Performance Under Cyber Security Vulnerabilities, Oscar A. Alvarez

Theses and Dissertations

The communication process is the key that characterizes the modern concept of smart grid, a new technology that introduced a “two-way communication” in energy measurement systems and can be best represented through the smart meters. Hence, the goal of smart metering communication is to ensure a secure and reliable transmission of information that can only be accessed by end users and energy supplying companies. With the goal of improving the information security in smart energy grids, the research presented in this work focused on studying different advanced metering infrastructure communication protocols and, it showcases a series of experiments performed on …

"Nothing Sacred" And The Impact Of Catharsis, Religious Iconography And Satire In Film, Jaime Danielle Trevino

Theses and Dissertations

Writing, or art of any kind, can be cathartic, depending on the subject matter. The term catharsis here refers to the experience shared by the tragic hero and audience in a common emotional tension that gets released in a fictional process that provides clarity. I would assert that the author should be included in this aesthetic and intellectual process. Creative writing can also be cathartic work and can allow the author to release pity and fear and gain clarity. In Nothing Sacred, the thesis screenplay written and explored here, I aim to find if catharsis can exist in both …

Parametric Study Of New Diaphragm Design Methods, Emily Rose Taylor

Architectural Engineering

Large retail buildings and warehouses are typically a one-story concrete or masonry walled structure with a panelized wood roof. These buildings fall under the category of “RWFD”, or “Rigid Wall Flexible Diaphragm”. There are two preexisting methods that can be utilized in designing flexible diaphragms, but there is a third being introduced in the new ASCE 7-22 code. Given this code is unreleased, there really is no guidance to the user as far as which method is the most time efficient or cost effective. The purpose of this project is to analyze the same building using each design method in …