Digital Commons Network^™

Widening Spinal Injury Research To Consider All Supraspinal Cell Types: Why We Must And How We Can, Murray G. Blackmore, Eliazbeth Batsel, Pantelis Tsoulfas

Biomedical Sciences Faculty Research and Publications

The supraspinal connectome consists of dozens of neuronal populations that project axons from the brain to the spinal cord to influence a wide range of motor, autonomic, and sensory functions. The complexity and wide distribution of supraspinal neurons present significant technical challenges, leading most spinal cord injury research to focus on a handful of major pathways such as the corticospinal, rubrospinal, and raphespinal. Much less is known about many additional populations that carry information to modulate or compensate for these main pathways, or which carry pre-autonomic and other information of high value to individuals with spinal injury. A confluence of …

Information Literacy For Global Inclusion: Designing An Annotated Bibliography For Global Search And Selection, Pamela A. Espinosa De Los Monteros, Elizabeth L. Black

Communications in Information Literacy

The COVID-19 pandemic has reinforced the notion that our world is global and interdependent. Despite the ever-increasing connection of global with local, there continues to be formidable barriers in accessing information produced in different international contexts and languages. This Innovative Practices article details the redesign of an annotated bibliography assignment in an international studies course to support the inclusion of global perspectives into the information practices of undergraduate students. The redesign embedded explicit information literacy dispositions and global citizenship education competencies through the search and selection of global information sources. The authors discuss the instructional elements used, student outcomes, and …

Remote Reference Consultations Are Here To Stay, Emily Reed

Communications in Information Literacy

Remote reference consultations have considerably increased due to the need to provide remote services during the COVID-19 pandemic. Conducting reference consultations via videoconferencing not only offers many benefits to student researchers it also presents an opportunity for librarians to embrace a learner-centered teaching mindset when approaching remote consultations by developing consultation learning goals in alignment with the Framework for Information Literacy for Higher Education. Designing consultations to be learner-centered yields benefits for students such as the student actively practicing their own searches as well as more thorough source evaluation. Additionally, videoconferencing technology allows for a more seamless information sharing …

A Safety Factor Approach To Designing Urban Infrastructure For Dynamic Conditions, Sanjib Sharma, Ben Seiyon Lee, Robert E. Nicholas, Klaus Keller

Dartmouth Scholarship

Current approaches to design flood-sensitive infrastructure typically assume a stationary rainfall distribution and neglect many uncertainties. These assumptions are inconsistent with observations that suggest intensifying extreme precipitation events and the uncertainties surrounding projections of the coupled natural-human systems. Here we demonstrate a safety factor approach to designing urban infrastructure in a changing climate. Our results show that assuming climate stationarity and neglecting deep uncertainties can drastically underestimate flood risks and lead to poor infrastructure design choices. We find that climate uncertainty dominates the socioeconomic and engineering uncertainties that impact the hydraulic reliability in stormwater drainage systems. We quantify the upfront …

A Distributed Fmri-Based Signature For The Subjective Experience Of Fear, Feng Zhou, Weihua Zhao, Ziyu Qi, Yayuan Geng, Shuxia Yao, Keith M. Kendrick, Tor D. Wager, Benjamin Becker

Dartmouth Scholarship

The specific neural systems underlying the subjective feeling of fear are debated in affective neuroscience. Here, we combine functional MRI with machine learning to identify and evaluate a sensitive and generalizable neural signature predictive of the momentary self-reported subjective fear experience across discovery (n = 67), validation (n = 20) and generalization (n = 31) cohorts. We systematically demonstrate that accurate fear prediction crucially requires distributed brain systems, with important contributions from cortical (e.g., prefrontal, midcingulate and insular cortices) and subcortical (e.g., thalamus, periaqueductal gray, basal forebrain and amygdala) regions. We further demonstrate that the neural representation of subjective fear …

Color Cherenkov Imaging Of Clinical Radiation Therapy, Daniel A. Alexander, Anthony Nomezine, Lesley A. Jarvis, David J. Gladstone, Brian W. Pogue, Petr Bruza

Dartmouth Scholarship

Color vision is used throughout medicine to interpret the health and status of tissue. Ionizing radiation used in radiation therapy produces broadband white light inside tissue through the Cherenkov effect, and this light is attenuated by tissue features as it leaves the body. In this study, a novel time-gated three-channel camera was developed for the first time and was used to image color Cherenkov emission coming from patients during treatment. The spectral content was interpreted by comparison with imaging calibrated tissue phantoms. Color shades of Cherenkov emission in radiotherapy can be used to interpret tissue blood volume, oxygen saturation and …

Entropy-Based Metrics For Predicting Choice Behavior Based On Local Response To Reward, Ethan Trepka, Mehran Spitmaan, Bilal A. Bari, Vincent D. Costa, Jeremiah Y. Cohen, Alireza Soltani

Dartmouth Scholarship

For decades, behavioral scientists have used the matching law to quantify how animals distribute their choices between multiple options in response to reinforcement they receive. More recently, many reinforcement learning (RL) models have been developed to explain choice by integrating reward feedback over time. Despite reasonable success of RL models in capturing choice on a trial-by-trial basis, these models cannot capture variability in matching behavior. To address this, we developed metrics based on information theory and applied them to choice data from dynamic learning tasks in mice and monkeys. We found that a single entropy-based metric can explain 50% and …

Pan-Cancer Evaluation Of Gene Expression And Somatic Alteration Data For Cancer Prognosis Prediction, Xingyu Zheng, Christopher I. Amos, H. Robert Frost

Dartmouth Scholarship

Background: Over the past decades, approaches for diagnosing and treating cancer have seen significant improvement. However, the variability of patient and tumor characteristics has limited progress on methods for prognosis prediction. The development of high-throughput omics technologies now provides multiple approaches for characterizing tumors. Although a large number of published studies have focused on integration of multi-omics data and use of pathway-level models for cancer prognosis prediction, there still exists a gap of knowledge regarding the prognostic landscape across multi-omics data for multiple cancer types using both gene-level and pathway-level predictors. Methods: In this study, we systematically evaluated three often …

Associations Between The Gut Microbiome And Metabolome In Early Life, Quang P. Nguyen, Margaret R. Karagas, Juliette C. Madan, Erika Dade, Thomas J. Palys, Hilary G. Morrison, Wimal W. Pathmasiri, Susan Mcritche, Susan J. Sumner, H. Robert Frost, Anne G. Hoen

Dartmouth Scholarship

Background: The infant intestinal microbiome plays an important role in metabolism and immune development with impacts on lifelong health. The linkage between the taxonomic composition of the microbiome and its metabolic phenotype is undefined and complicated by redundancies in the taxon-function relationship within microbial communities. To inform a more mechanistic understanding of the relationship between the microbiome and health, we performed an integrative statistical and machine learning-based analysis of microbe taxonomic structure and metabolic function in order to characterize the taxa-function relationship in early life. Results: Stool samples collected from infants enrolled in the New Hampshire Birth Cohort Study (NHBCS) …

Healing Through History: A Qualitative Evaluation Of A Social Medicine Consultation Curriculum For Internal Medicine Residents, Joel Bradley, David Styren, Abigail Laplante, John Howe, Sienna R. Craig, Emily Cohen

Dartmouth Scholarship

Background: Social context guides care; stories sustain meaning; neither is routinely prioritized in residency training. Healing Through History (HTH) is a social medicine consultation curriculum integrating social determinants of health narrative into clinical care for medically and socially complex patients. The curriculum is part of an internal medicine (IM) residency outpatient clinical rotation at a Veterans Health Administration hospital. Our aim was to explore how in-depth social medicine consultations may impact resident clinical practice and foster meaning in work. Methods: From 2017 to 2019, 49 categorical and preliminary residents in their first year of IM training were given two half-day …

Measuring And Modeling Energy And Power Consumption In Living Microbial Cells With A Synthetic Atp Reporter, Yijie Deng, Douglas Raymond Beahm, Steven Ionov, Rahul Sarpeshkar

Dartmouth Scholarship

Background: Adenosine triphosphate (ATP) is the main energy carrier in living organisms, critical for metabolism and essential physiological processes. In humans, abnormal regulation of energy levels (ATP concentration) and power consumption (ATP consumption flux) in cells is associated with numerous diseases from cancer, to viral infection and immune dysfunction, while in microbes it influences their responses to drugs and other stresses. The measurement and modeling of ATP dynamics in cells is therefore a critical component in understanding fundamental physiology and its role in pathology. Despite the importance of ATP, our current understanding of energy dynamics and homeostasis in living cells …

Clinically Relevant Dual Probe Difference Specimen Imaging (Ddsi) Protocol For Freshly Resected Breast Cancer Specimen Staining, Broderick J. House, Marcus J. Kwon, Jasmin M. Schaefer, Connor W. Barth, Allison Solanki, Scott C. Davis, Summer L. Gibbs

Dartmouth Scholarship

Background: Re-excision rates following breast conserving surgery (BCS) remain as high as ~ 35%, with positive margins detected during follow-up histopathology. Additional breast cancer resection surgery is not only taxing on the patient and health care system, but also delays adjuvant therapies, increasing morbidity and reducing the likelihood of a positive outcome. The ability to precisely resect and visualize tumor margins in real time within the surgical theater would greatly benefit patients, surgeons and the health care system. Current tumor margin assessment technologies utilized during BCS involve relatively lengthy and labor-intensive protocols, which impede the surgical work flow. Methods: In …

Sprd: A Surface Plasmon Resonance Database Of Common Factors For Better Experimental Planning, Purushottam B. Tiwari, Camelia Bencheqroun, Mario Lemus, Taryn Shaw, Marilyn Kouassi-Brou, Adil Alaoui, Aykut Üren

Dartmouth Scholarship

Background: Surface plasmon resonance is a label-free biophysical technique that is widely used in investigating biomolecular interactions, including protein-protein, protein-DNA, and protein-small molecule binding. Surface plasmon resonance is a very powerful tool in different stages of small molecule drug development and antibody characterization. Both academic institutions and pharmaceutical industry extensively utilize this method for screening and validation studies involving direct molecular interactions. In most applications of the surface plasmon resonance technology, one of the studied molecules is immobilized on a microchip, while the second molecule is delivered through a microfluidic system over the immobilized molecules. Changes in total mass on …

Tactile Materials In Practice: Understanding The Experiences Of Teachers Of The Visually Impaired, Mahika Phutane, Julie Wright, Brenda Veronica Castro, Lei Shi, Simone R. Stern, Holly Lawson, Shiri Azenkot

Special Education Faculty Publications and Presentations

Teachers of the visually impaired (TVIs) regularly present tactile materials (tactile graphics, 3D models, and real objects) to students with vision impairments. Researchers have been increasingly interested in designing tools to support the use of tactile materials, but we still lack an in-depth understanding of how tactile materials are created and used in practice today. To address this gap, we conducted interviews with 21 TVIs and a 3-week diary study with eight of them. We found that tactile materials were regularly used for academic as well as non-academic concepts like tactile literacy, motor ability, and spatial awareness. Real objects and …

Empowering Teacher Candidates To Create Social Justice Curriculum Through Civic Engagement Projects, Gayle Y. Thieman

Education Faculty Publications and Presentations

The purpose of this research is to examine how participating in a Civic Engagement Project (CEP) led teacher candidates (TCs) to develop and publish race and social justice curriculum. This article describes the CEP, a graduate level social studies methods course assignment for TCs who research community issues, select a class project, collaborate, create and publish resources for educators. This mixed-methods study examines the challenges, benefits and process of the CEP. TCs' reflections, digital curriculum and resources they created, surveys and interviews with TCs after graduation were analyzed through six criteria of anti-racist curriculum, based on Racial Pedagogical Content Knowledge …

Testing For Cognitive Deficits After Mild Traumatic Brain Injury Using The Automated Neuropsychological Assessment Metric And Dual-Task Assessments, Jasmin Mabry

University Honors Theses

Cognitive deficits are common following mTBI. DT gait assessments and seated computerized exams are often used for evaluating those deficits. Little is known about DT gait and neurocognitive performance in a chronic population. We compared people with chronic mTBI and subacute mTBI to healthy controls (HC) on DT gait and neurocognitive performance and explored the relationship of DT gait performance with a traditional neurocognitive (TNC) exam.

Subjects completed a computerized TNC - the ANAM - and a motor-cognitive DT test which assessed both DT motor performance as well as the cognitive task accuracy. The DT test consisted of subjects walking …

The Impact Of The Menstrual Cycle On Female Performance In Athletics, Calli Doan

Senior Honors Theses

Female hormones, key to preparing a woman's body for childbirth, work in a magnificent, cyclical manner. It can be expected that these hormones, with the role of preparing a woman's body to conceive a child and deliver a life safely into the world, would have a large impact on the health of the female, especially when it comes to athletics. Numerous studies conducted to understand the full extent of the effect of reproductive hormones on the female body have shown that these hormones influence not only menstruation, but also various physiological and psychological elements. Such effects can certainly impact athletic …

Identifying Incident Casual Factors To Improve Aviation Transportation Safety: Proposing A Deep Learning Approach, Tianxi Dong, Q. Yang, N. Ebadi, X. R. Luo, P. Rad

School of Business Faculty Research

Aviation is a complicated transportation system, and safety is of paramount importance because aircraft failure often involves casualties. Prevention is clearly the best strategy for aviation transportation safety. Learning from past incident data to prevent potential accidents from happening has proved to be a successful approach. To prevent potential safety hazards and make effective prevention plans, aviation safety experts identify primary and contributing factors from incident reports. However, safety experts’ review processes have become prohibitively expensive nowadays. The number of incident reports is increasing rapidly due to the acceleration of advances in information technologies and the growth of the commercial …

The Meaning Of Movement: Using Motion Design To Enrich Words For Deaf And Hard Of Hearing Children, Hannah Elyse Colasurdo

Masters Theses

This thesis aims to address challenging areas of vocabulary for deaf and hard of hearing children by developing an open resource for students, parents, teachers, and content creators that utilizes motion to enhance written words for deaf and hard of hearing children. This research seeks to study the means of nonverbal communication such as body language expression and paralinguistic prosody (i.e., tone, intonation, volume, and pitch) qualities within the framework of graphic design through motion design. Body movement and expression are essential during face-to-face communication, but written language lacks such context clues. Additionally, the hard of hearing may not fully …

Evaluation Of A Novel Approach For Assessing Biological Activity In Agricultural Soils, Karla Melgar

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Soil health is a key factor impacting soil resilience and fertility in crop production systems. Favorable soil physical and biological conditions facilitate plant nutrient absorption and nutrient cycling. Demonstrating to farmers the impacts and changes in soil biological activity under different soil management practices has been a challenge due to the limited availability of inexpensive tools for quantifying this component of soil health. The primary goal of this study was to present a simple and readily accessible tool for evaluating soil biological activity to promote the use of organic amendments in crop fields. Research plots were established in two studies …

High-Frequency Unmanned Aircraft Flights For Crop Canopy Imaging During Diurnal Moisture Stress, Suresh Pradhyun Kashyap

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Previous research has used unmanned aerial vehicle (UAV) technology for calculating CWSI (Crop Water Stress Index) values in the context of irrigation scheduling. Typically, these estimations were taken at one time of day, usually near shortly after solar noon. A significant limitation with these CWSI values is that the UAV thermal imagery captured at this point in time can be affected by various factors like atmospheric air temperature, solar radiation, wind speed, relative humidity, and other micrometeorological disturbances in the air. In order to address these temporal effects, high-frequency UAV flights were conducted over different daylight hours to analyze and …

Request For Modification 21-019 To Resource Conservation And Recovery Act (Rcra) Facility Operating Permit, Sandia National Laboratories/New Mexico (Snl/Nm), Sandia National Laboratories/Nm Snl

Facilities-Units

The Department of Energy/National Nuclear Security Administration (DOE/NNSA) and Sandia National Laboratories, New Mexico (SNL/NM) have requested modifications to the Resource Conservation and Recovery Act Facility Operating Permit (Permit) for Sandia National Laboratories/New Mexico. The requested modifications consist of revisions to the Mixed Waste Landfill (MWL) Long-Term Monitoring and Maintenance Plan (LTMMP), which is incorporated by reference into Permit Attachment M, "Long-Term Monitoring and Maintenance Plan for Solid Waste Management Units and Areas of Concern Granted Corrective Action Complete with Controls." The MWL is also known as Solid Waste Management Unit (SWMU) 76.

The DOE/NNSA and SNL/NM propose to make …

Amplifying The "A" In Steam Education, Grace Floerke

Honors College Theses

This paper discusses the importance of teachers implementing STEAM education in the classroom. Previously, science, technology, engineering, and mathematics (abbreviated as STEM) education was used as a tool to prepare students to excel in career fields that are projected to grow in the near future. However, recently the acronym was changed to STEAM to add “the arts” to the original acronym. It is imperative that the arts are seen as an equal to STEM, as they can complement and enhance the goals STEM is trying to reach. Since not all students possess the same interest, ways of learning, or abilities, …

Vacatur Pending En Banc Review, Ruby Emberling

Michigan Law Review

When a case becomes moot on appeal, as when the parties settle, two primary Supreme Court cases guide the appellate court’s decision about whether to vacate the lower-court opinion. The Court has said that vacatur, an equitable remedy, promotes fairness to parties who were not responsible for the mootness because it erases adverse legal outcomes the litigants were prevented from appealing. Beyond this, vacatur is inadvisable since it eliminates precedential decisions and harms the judiciary’s efficiency and legitimacy. Yet this doctrinal order has not been uniformly brought to bear on the highly similar question of whether to vacate when a …

Young And Dangerous: The Role Of Youth In Risk Assessment Instruments, Ingrid Yin

Michigan Law Review

States are increasingly adopting risk assessment instruments (RAIs) to help judges determine the appropriate type and length of punishment for an offender. Although this sentencing practice has been met with a wide variety of scholarly criticism, there has been virtually no discussion of how RAIs treat youth as a strong factor contributing to a high risk score. This silence is puzzling. Not only is youth undoubtedly the most powerful risk factor in most RAIs, but youth also holds a special place in the criminal justice system as a “mitigating factor of great weight.” This Comment presents the first in-depth critique …

Comparison Of Machine Learning Clustering Algorithms For Detecting Heterogeneity Of Treatment Effect In Acute Respiratory Distress Syndrome: A Secondary Analysis Of Three Randomised Controlled Trials, Pratik Sinha, Alexandra Spicer, Kevin L Delucchi, Daniel F Mcauley, Carolyn S Calfee, Matthew M Churpek

Open Access Publications

BACKGROUND: Heterogeneity in Acute Respiratory Distress Syndrome (ARDS), as a consequence of its non-specific definition, has led to a multitude of negative randomised controlled trials (RCTs). Investigators have sought to identify heterogeneity of treatment effect (HTE) in RCTs using clustering algorithms. We evaluated the proficiency of several commonly-used machine-learning algorithms to identify clusters where HTE may be detected.

METHODS: Five unsupervised: Latent class analysis (LCA), K-means, partition around medoids, hierarchical, and spectral clustering; and four supervised algorithms: model-based recursive partitioning, Causal Forest (CF), and X-learner with Random Forest (XL-RF) and Bayesian Additive Regression Trees were individually applied to three prior …

Efficacy And Safety Of Avapritinib In Advanced Systemic Mastocytosis: Interim Analysis Of The Phase 2 Pathfinder Trial, Jason Gotlib, Andreas Reiter, Stephen T Oh, Et Al

Open Access Publications

Advanced systemic mastocytosis (AdvSM) is a rare, KIT D816V-driven hematologic neoplasm characterized by mast cell infiltration and shortened survival. We report the results of a prespecified interim analysis of an ongoing pivotal single-arm phase 2 trial (no. NCT03580655 ) of avapritinib, a potent, selective KIT D816V inhibitor administered primarily at a once-daily starting dose of 200 mg in patients with AdvSM (n = 62). The primary endpoint was overall response rate (ORR). Secondary endpoints included mean baseline change in AdvSM-Symptom Assessment Form Total Symptom Score and quality of life, time to response, duration of response, progression-free survival, overall survival, changes …

How The Value Of The Environment Controls Persistence In Visual Search, Michael R. Traner, Ethan S. Bromberg-Martin, Ilya E. Monosov

Open Access Publications

Classic foraging theory predicts that humans and animals aim to gain maximum reward per unit time. However, in standard instrumental conditioning tasks individuals adopt an apparently suboptimal strategy: they respond slowly when the expected value is low. This reward-related bias is often explained as reduced motivation in response to low rewards. Here we present evidence this behavior is associated with a complementary increased motivation to search the environment for alternatives. We trained monkeys to search for reward-related visual targets in environments with different values. We found that the reward-related bias scaled with environment value, was consistent with persistent searching after …

Identification Of Histone Deacetylase Inhibitors With (Arylidene)Aminoxy Scaffold Active In Uveal Melanoma Cell Lines, Susanna Nencetti, Doretta Cuffaro, Elisa Nuti, Lidia Ciccone, Armando Rossello, Marina Fabbi, Flavio Ballante, Gabriella Ortore, Grazia Carbotti, Francesco Campelli, Irene Banti, Rosaria Gangemi, Garland R Marshall, Elisabetta Orlandini

Open Access Publications

Uveal melanoma (UM) represents an aggressive type of cancer and currently, there is no effective treatment for this metastatic disease. In the last years, histone deacetylase inhibitors (HDACIs) have been studied as a possible therapeutic treatment for UM, alone or in association with other chemotherapeutic agents. Here we synthesised a series of new HDACIs based on the SAHA scaffold bearing an (arylidene)aminoxy moiety. Their HDAC inhibitory activity was evaluated on isolated human HDAC1, 3, 6, and 8 by fluorometric assay and their binding mode in the catalytic site of HDACs was studied by molecular docking. The most promising hit was …

Fabrication And Evaluation Of Bilateral Helmholtz Radiofrequency Coil For Thermo-Stable Breast Image With Reduced Artifacts, Young Han Lee, Kyu-Ho Song, Jaemoon Yang, Won Jun Kang, Keum Sil Lee, Min Jung Kim, Eun-Kyung Kim, Dan Heo, Bo-Young Choe, Jin-Suck Suh

Open Access Publications

PURPOSE: The positron emission tomography (PET)-magnetic resonance (MR) system is a newly emerging technique that yields hybrid images with high-resolution anatomical and metabolic information. With PET-MR imaging, a definitive diagnosis of breast abnormalities will be possible with high spatial accuracy and images will be acquired for the optimal fusion of anatomic locations. Therefore, we propose a PET-compatible two-channel breast MR coil with minimal disturbance to image acquisition which can be used for simultaneous PET-MR imaging in patients with breast cancer.

MATERIALS AND METHODS: For coil design and construction, the conductor loops of the Helmholtz coil were tuned, matched, and subdivided …