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2021

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Dancing The Pilates Way: The Possible Effects Of Pilates On The Alignment Of A Dancers' Body, Darla Jentzsch Dec 2021

Dancing The Pilates Way: The Possible Effects Of Pilates On The Alignment Of A Dancers' Body, Darla Jentzsch

Master's Theses

The purpose of this research was to investigate any mental and physical benefits that Pilates Exercises might have on dancers’ alignment. The researcher collected quantitative and qualitative data to answer these four research questions: Q1: How can a dancer’s alignment be measured to see change after ten Pilates Classes? Q2: Can Pilates bring a dancers’ body closer to ideal alignment in ten Pilates classes? Q3: What do dancers notice differently in their dancing after having been taught Pilates? Q4: What are the benefits of having proper alignment as a dancer? The researcher examined the effects of the Pilates exercises on …


Reflective Practices In The Dance Studio: Implementing Deliberate Observation And Examination Methods Into The Dance Technique Class For Youth To Encourage The Development Of Self-Awareness, Meredith Orrell Dec 2021

Reflective Practices In The Dance Studio: Implementing Deliberate Observation And Examination Methods Into The Dance Technique Class For Youth To Encourage The Development Of Self-Awareness, Meredith Orrell

Master's Theses

The purpose of this study was to investigate the effects of a reflective pedagogy on younger students in the dance studio setting. Three research questions were designed to be answered by this study. Q1 In what ways are reflective practices effective in a dance studio setting? Q2 Are reflective practices effective for younger students? Q3 How can reflective practices be applied effectively in future dance classes? Five students participated in the study by completing weekly self-evaluation progress forms and reflective journal entries. The researcher at the same time completed an observation form of the participants’ progresses. These research instruments composed …


Development Of A Culturally Adaptable Educational Program On Iron-Deficiency Anemia For Use In Resource-Limited Communities., Julie Hirman Dec 2021

Development Of A Culturally Adaptable Educational Program On Iron-Deficiency Anemia For Use In Resource-Limited Communities., Julie Hirman

Doctoral Scholarly Projects & Capstones

Iron deficiency anemia (IDA) is a significant global health issue that disproportionally impacts individuals living in resource-limited countries. Access to professional healthcare in these regions is limited and rural communities often rely on specific community members for their basic health care needs. These community members, commonly referred to as community health promotors (CHPs), are seen as knowledgeable in informal or traditional healing practices and are often sought out when illnesses are present. This is a dynamic that could be cultivated and promoted to prevent and treat early stages of IDA. With culturally tailored support and education, advancing the healthcare knowledge …


Implementation Of An Interprofessional Fall Prevention Program To Reduce Falls On An Older Adult Inpatient Psychiatric Unit, Teresa Woodson Dec 2021

Implementation Of An Interprofessional Fall Prevention Program To Reduce Falls On An Older Adult Inpatient Psychiatric Unit, Teresa Woodson

Doctor of Nursing Practice

Background. Falls are the most reported incidents in the hospital setting, especially among older adults. According to the National Database of Nursing Quality Indicators (NDNQI), the number of falls in inpatient psychiatric units is 13-25 per 1,000 patient days, compared to 4 per 1,000 days for medical-surgical units. This DNP project aims to implement an interprofessional fall risk team to reduce falls in an older adult inpatient psychiatric unit. Problem. The psychiatric inpatient units had a total of 31 falls, with 13 (40%) occurring on the older adult unit. Interventions. Education of nursing staff, providers, and physical therapy (PT) …


Association Of Serum Magnesium With Blood Pressure In Patients With Hypertensive Crises: A Retrospective Cross-Sectional Study, Ifeanyichukwu O. Onor, Lashira M. Hill, Modupe M. Famodimu, Mallory R. Coleman, Carolkim H. Huynh, Robbie A. Beyl, Casey J. Payne, Emily K. Johnston, John I. Okogbaa, Christopher J. Gillard, Daniel F. Sarpong, Amne Borghol, Samuel C. Okpechi, Ifeyinwa Norbert, Shane E. Sanne, Shane G. Guillory Dec 2021

Association Of Serum Magnesium With Blood Pressure In Patients With Hypertensive Crises: A Retrospective Cross-Sectional Study, Ifeanyichukwu O. Onor, Lashira M. Hill, Modupe M. Famodimu, Mallory R. Coleman, Carolkim H. Huynh, Robbie A. Beyl, Casey J. Payne, Emily K. Johnston, John I. Okogbaa, Christopher J. Gillard, Daniel F. Sarpong, Amne Borghol, Samuel C. Okpechi, Ifeyinwa Norbert, Shane E. Sanne, Shane G. Guillory

School of Graduate Studies Faculty Publications

The role of magnesium in blood pressure has been studied among hypertensive patients; however, there is a dearth of studies exploring the role of magnesium in hypertensive crises. The primary objective of this study was to evaluate the relationship between serum magnesium and blood pressure in patients with hypertensive crises. This was a singlecenter, retrospective, chart review, cross-sectional study of patients with hypertensive crises. Patients were included if they were eighteen years of age or older, with an international classification disease ninth revision (ICD-9) code of 401.9 (hypertensive crises: emergency or urgency) and a documented magnesium level on their electronic …


Augmented Reality-Assisted Problem-Based Learning E-Module To Improve Problem-Solving Skills, Zurienia Mimi Bibiyana, Fatchur Rohman, Mimien Henie Irawati Al-Muhdhar Dec 2021

Augmented Reality-Assisted Problem-Based Learning E-Module To Improve Problem-Solving Skills, Zurienia Mimi Bibiyana, Fatchur Rohman, Mimien Henie Irawati Al-Muhdhar

Jurnal Pendidikan Sains

Problem-solving skills in the field of biology play an important role in representing problems, identifying relationships, making predictions, and verifying or evaluating solutions. This study aimed to implement an augmented reality-assisted problem-based learning e-module on bioindicator materials to improve students’ problem-solving skills. The research method used was a pre-experimental one-group pretest-posttest design involving 29 biology students at the State University of Malang in the 2020/2021 academic year. The results of the paired t-test showed that the significance value (p) for the pretest and posttest was 0.000 (< 0.05), indicating that the e-module had a significant effect on improving students’ problem-solving skills.


Privacy-Aware And Hardware-Based Accleration Authentication Scheme For Internet Of Drones, Tom Henson Dec 2021

Privacy-Aware And Hardware-Based Accleration Authentication Scheme For Internet Of Drones, Tom Henson

Master's Theses

Drones are becoming increasingly present into today’s society through many different means such as outdoor sports, surveillance, delivery of goods etc. With such a rapid increase, a means of control and monitoring is needed as the drones become more interconnected and readily available. Thus, the idea of Internet of drones (IoD) is formed, an infrastructure in place to do those types of things. However, without an authentication system in place anyone could gain access or control to real time data to multiple drones within an area. This is a problem that I choose to tackle using a Field Programmable Gate …


5-Ht Recruits Distinct Neurocircuits To Inhibit Hunger-Driven And Non-Hunger-Driven Feeding, Yanlin He, Xing Cai, Hailan Liu, Krisitine M Conde, Pingwen Xu, Yongxiang Li, Chunmei Wang, Meng Yu, Yang He, Hesong Liu, Chen Liang, Tingting Yang, Yongjie Yang, Kaifan Yu, Julia Wang, Rong Zheng, Feng Liu, Zheng Sun, Lora Heisler, Qi Wu, Qingchun Tong, Canjun Zhu, Gang Shu, Yong Xu Dec 2021

5-Ht Recruits Distinct Neurocircuits To Inhibit Hunger-Driven And Non-Hunger-Driven Feeding, Yanlin He, Xing Cai, Hailan Liu, Krisitine M Conde, Pingwen Xu, Yongxiang Li, Chunmei Wang, Meng Yu, Yang He, Hesong Liu, Chen Liang, Tingting Yang, Yongjie Yang, Kaifan Yu, Julia Wang, Rong Zheng, Feng Liu, Zheng Sun, Lora Heisler, Qi Wu, Qingchun Tong, Canjun Zhu, Gang Shu, Yong Xu

Children’s Nutrition Research Center Staff Publications

Obesity is primarily a consequence of consuming calories beyond energetic requirements, but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons in the dorsal Raphe nucleus (5-HTDRN) regulate different types of feeding behavior, such as eating to cope with hunger or for pleasure. Here, we observed that activation of 5-HTDRN to hypothalamic arcuate nucleus (5-HTDRN → ARH) projections inhibits food intake driven by hunger via actions at ARH 5-HT2C and 5-HT1B receptors, whereas activation of 5-HTDRN to ventral tegmental area (5-HTDRN → VTA) projections inhibits non-hunger-driven feeding via actions at 5-HT2C receptors. Further, hunger-driven feeding gradually activates ARH-projecting 5-HTDRN …


Intermittent Bolus Feeding Does Not Enhance Protein Synthesis, Myonuclear Accretion, Or Lean Growth More Than Continuous Feeding In A Premature Piglet Model, Marko Rudar, Jane K Naberhuis, Agus Suryawan, Hanh V Nguyen, Barbara Stoll, Candace C Style, Mariatu A Verla, Oluyinka O Olutoye, Douglas G Burrin, Marta L Fiorotto, Teresa A Davis Dec 2021

Intermittent Bolus Feeding Does Not Enhance Protein Synthesis, Myonuclear Accretion, Or Lean Growth More Than Continuous Feeding In A Premature Piglet Model, Marko Rudar, Jane K Naberhuis, Agus Suryawan, Hanh V Nguyen, Barbara Stoll, Candace C Style, Mariatu A Verla, Oluyinka O Olutoye, Douglas G Burrin, Marta L Fiorotto, Teresa A Davis

Children’s Nutrition Research Center Staff Publications

Optimizing enteral nutrition for premature infants may help mitigate extrauterine growth restriction and adverse chronic health outcomes. Previously, we showed in neonatal pigs born at term that lean growth is enhanced by intermittent bolus compared with continuous feeding. The objective was to determine if prematurity impacts how body composition, muscle protein synthesis, and myonuclear accretion respond to feeding modality. Following preterm delivery, pigs were fed equivalent amounts of formula delivered either as intermittent boluses (INT; n = 30) or continuously (CONT; n = 14) for 21 days. Body composition was measured by dual-energy X-ray absorptiometry (DXA) and muscle growth was …


Dash Diet Adherence And Cognitive Function: Multi-Ethnic Study Of Atherosclerosis, George D Daniel, Haiying Chen, Alain G Bertoni, Stephen R Rapp, Annette L Fitzpatrick, José A Luchsinger, Alexis C Wood, Timothy M Hughes, Gregory L Burke, Kathleen M Hayden Dec 2021

Dash Diet Adherence And Cognitive Function: Multi-Ethnic Study Of Atherosclerosis, George D Daniel, Haiying Chen, Alain G Bertoni, Stephen R Rapp, Annette L Fitzpatrick, José A Luchsinger, Alexis C Wood, Timothy M Hughes, Gregory L Burke, Kathleen M Hayden

Children’s Nutrition Research Center Staff Publications

Background and aims: The Adherence to the Dietary Approaches to Stop Hypertension (DASH) diet has been associated with better cognitive function in studies of predominantly White participants; few studies have examined this association in diverse cohorts. Our objective was to examine the association between the DASH diet and cognitive function in the diverse Multi-Ethnic Study of Atherosclerosis (MESA) cohort.

Methods: Among 4169 MESA participants, we evaluated prospectively, the association between DASH diet adherence and cognitive function. Participants completed a food frequency questionnaire at baseline (2000-2002) and cognitive function was assessed using the Cognitive Abilities Screening Instrument (CASI), Digit Symbol Coding …


Pcor Partnership Atlas, Wesley D. Peck, Earl P. Battle, Kari Suedel, Kyle A. Glazewski, Kevin C. Connors, James A. Sorensen, John A. Hamling, Charles D. Gorecki, Edward N. Steadman, John A. Harju Dec 2021

Pcor Partnership Atlas, Wesley D. Peck, Earl P. Battle, Kari Suedel, Kyle A. Glazewski, Kevin C. Connors, James A. Sorensen, John A. Hamling, Charles D. Gorecki, Edward N. Steadman, John A. Harju

EERC Maps and Infographics

The Plains CO2 Reduction (PCOR) Partnership Atlas provides a regional profile of CO2 sources and potential storage locations across the PCOR Partnership region. The sixth edition provides an up-to-date look at PCOR Partnership initiative activities, including additional regional characterization and updates on commercial projects. Additional background information on carbon capture, utilization, and storage (CCUS) is included to give a better understanding of how CCUS addresses concerns about climate change while allowing future energy needs to be met.


The Year Of Brood Viii, Jona L. Pederson Dec 2021

The Year Of Brood Viii, Jona L. Pederson

Greenway Press Chapbooks

No abstract provided.


Extending The Argument: A Case Study Exploring How To Decay Consumer Grudges In A Social Media World, Onnolee Nordstrom, Laura Egan Dec 2021

Extending The Argument: A Case Study Exploring How To Decay Consumer Grudges In A Social Media World, Onnolee Nordstrom, Laura Egan

Librarian Publications

We study the process involved in diminishing consumer grudges against an industry. Through a qualitative case study of an organization tasked with changing consumer’s negative perceptions and beliefs about the Canadian agriculture industry, we uncover how the process of decaying grudges involves presenting information, creating credibile sources, and building positive affect. Our findings extend Thota and Wright’s (2006) grudgeholding decay framework.


Hierarchical Control Of Multi-Agent Reinforcement Learning Team In Real-Time Strategy (Rts) Games, Weigui Jair Zhou, Budhitama Subagdja, Ah-Hwee Tan, Darren Wee Sze Ong Dec 2021

Hierarchical Control Of Multi-Agent Reinforcement Learning Team In Real-Time Strategy (Rts) Games, Weigui Jair Zhou, Budhitama Subagdja, Ah-Hwee Tan, Darren Wee Sze Ong

Research Collection School Of Computing and Information Systems

Coordinated control of multi-agent teams is an important task in many real-time strategy (RTS) games. In most prior work, micromanagement is the commonly used strategy whereby individual agents operate independently and make their own combat decisions. On the other extreme, some employ a macromanagement strategy whereby all agents are controlled by a single decision model. In this paper, we propose a hierarchical command and control architecture, consisting of a single high-level and multiple low-level reinforcement learning agents operating in a dynamic environment. This hierarchical model enables the low-level unit agents to make individual decisions while taking commands from the high-level …


The Oakland Athletics Use Of Sabermetrics And The Rise Of Big Data Analytics In Business, Jacob Moorefield Dec 2021

The Oakland Athletics Use Of Sabermetrics And The Rise Of Big Data Analytics In Business, Jacob Moorefield

Honors Theses

The Moneyball phenomenon revealed how Billy Beane, the Oakland Athletics general manager utilized advanced data analytics; Sabermetrics, to statistically analyze the data in baseball which aims to quantify baseball players’ performances based on objective statistical measurements. As technology increases and big data becomes more accessible, sports organizations like the Oakland Athletics are illustrating how businesses, small and large, can use advanced analytics to promote growth. This research paper provides a meta-analysis on the results of large businesses using big data analytic techniques similar to Sabermetrics, to show the improvements in marketing, consumer outreach, revenue, and employee retention while questioning whether …


The Combined Influences Of Race, Sexuality, And Gender On Perceptions Of Sexual Harassment, Courtney House Dec 2021

The Combined Influences Of Race, Sexuality, And Gender On Perceptions Of Sexual Harassment, Courtney House

Honors Theses

The current research examines the perceptions of sexual harassment based on the influence of the victim’s gender, and the race of both the victim and the perpetrator, and perceiver’s feminist beliefs. By using vignettes (a brief description of an event), we manipulated a) the gender of the victim (man or woman), b) the race of the victim (POC or white), and c) the race of the perpetrator (POC or white). Our hypotheses were as follows: a) vignettes depicting same-sex harassment will be less in line with the definition of sexual harassment; b) vignettes portraying the victim as a woman of …


“A Penny For Your Thoughts:” Developing An Adapted Stimulus Reward Association – Stroop Task To Assess The Impact Of Individual Difference Factors On Cognitive Control, Mia Melone Dec 2021

“A Penny For Your Thoughts:” Developing An Adapted Stimulus Reward Association – Stroop Task To Assess The Impact Of Individual Difference Factors On Cognitive Control, Mia Melone

Honors Theses

Limited studies have examined the effect of feedback sensitivity and intrinsic motivation on cognitive performance. The present study serves as a pilot project for a study at the University of Tennessee at Chattanooga that examines the modulating role of external, monetary reward incentives and cognitive intrinsic motivation on cognitive control. For the present study, the relationship among cognitive performance outcomes (reaction time and accuracy) on an adapted Stimulus Reward Association Stroop Task will be explored. Two main hypotheses were tested in the present study: H1 Reaction time on congruent trials will be significantly faster than reaction time on incongruent trials. …


“Impresse Et Diligenter Correcte”: Johann Koelhoff The Elder’S Transmission Of Francesco Griffolini’S Latin Translation Of Chrysostom’S Homilies On John, Chris L. Nighman Dec 2021

“Impresse Et Diligenter Correcte”: Johann Koelhoff The Elder’S Transmission Of Francesco Griffolini’S Latin Translation Of Chrysostom’S Homilies On John, Chris L. Nighman

History Faculty Publications

No abstract provided.


Recapture And Reuse Of Nitrogen And Phosphorus From Rendered Animal Materials To Enhance Nutrient Use Efficiency And Produce Quality In Agricultural Crop, Bhupinder Jatana Dec 2021

Recapture And Reuse Of Nitrogen And Phosphorus From Rendered Animal Materials To Enhance Nutrient Use Efficiency And Produce Quality In Agricultural Crop, Bhupinder Jatana

All Dissertations

The current fertilizer regime heavily relies on inorganic fertilizers to meet the crop nitrogen (N) and phosphorus (P) demand. However, the United States has a limited N production capacity, with 50% N demand met through imports. On the other hand, the nonrenewable natural reserves of P are being depleted at an unprecedented rate and are expected to be exhausted with in next 100 years. Additionally, high solubility/liability of the field applied inorganic fertilizers often results in lower nutrient use efficiency (NUE;

The MBM led to rapid N mineralization, with 35% of the applied N mineralized within the first five days …


Exploring The Impact Of Authentic Assessment On Sustainability Literacy Through Reflective And Action-Oriented Tasks: A Roundtable Podcast, Olivia Freeman, Deirdre Duffy, Alacoque Mcalpine, Ciara Nolan Dr, Cormac Mcmahon, Lucia Walsh Dec 2021

Exploring The Impact Of Authentic Assessment On Sustainability Literacy Through Reflective And Action-Oriented Tasks: A Roundtable Podcast, Olivia Freeman, Deirdre Duffy, Alacoque Mcalpine, Ciara Nolan Dr, Cormac Mcmahon, Lucia Walsh

Irish Journal of Academic Practice

Business schools must engage in fundamental change to retain their legitimacy and position themselves as providers of solutions to urgent economic, social, and environmental crises. To this end, we need pedagogy that enables students to become sustainability literate graduates and thus develop appropriate knowledge, skills, and mind-sets. This roundtable discussion podcast comprises six colleagues engaged in conversation and reflection around a pedagogical initiative designed with the broad aim of enhancing sustainability literacy among business students using innovative digital tools as part of an authentic assessment strategy. The pedagogical approaches we discuss engage students with learning across several different modes and …


Computational Investigations Of The Photochemical Properties Of B12-Dependent Systems: From Solution To Enzymes., Megan Toda Mackintosh Dec 2021

Computational Investigations Of The Photochemical Properties Of B12-Dependent Systems: From Solution To Enzymes., Megan Toda Mackintosh

Electronic Theses and Dissertations

The photochemical properties of the B12 family of molecules (cobalamins = Cbls) have been known for many years yet only until the 21st century have applications for the light-sensitivity of Cbls come to the surface. Photolabile Cbls can be used for the delivery of therapeutics with spatial and temporal control, in the generation of hydroxyl radicals, and in nature, as demonstrated in the catalytic cycle of coenzyme B12-dependent photoreceptors. This dissertation describes the use of computational methods to explore the photochemical properties of Cbl systems including antivitamins B12, a thiolato-cobalamin, and the coenzyme B …


Video Games And Their Potential As Literacy Tools, Jessica Reich Dec 2021

Video Games And Their Potential As Literacy Tools, Jessica Reich

University Honors Program Senior Projects

Video games are an essential part of emergent popular culture, with millions playing games every day. With how popular gaming has become, it is logical to research its full potential as a literacy tool both inside and outside the classroom. This thesis contributes to the discussion of the importance and potential of video games as a literacy tool that can be utilized educationally and through gaming at home. This thesis includes a section for gaming definitions, a literature review on research on video games and their impact on education and literacy skill development, a discussion of video game narratives, and …


Estimating Smart Wi-Fi Thermostat-Enabled Thermal Comfort Control Savings For Any Residence, Abdulelah D. Alhamayani, Qiancheng Sun, Kevin Hallinan Dec 2021

Estimating Smart Wi-Fi Thermostat-Enabled Thermal Comfort Control Savings For Any Residence, Abdulelah D. Alhamayani, Qiancheng Sun, Kevin Hallinan

Mechanical and Aerospace Engineering Faculty Publications

Nowadays, most indoor cooling control strategies are based solely on the dry-bulb temperature, which is not close to a guarantee of thermal comfort of occupants. Prior research has shown cooling energy savings from use of a thermal comfort control methodology ranging from 10 to 85%. The present research advances prior research to enable thermal comfort control in residential buildings using a smart Wi-Fi thermostat. "Fanger's Predicted Mean Vote model" is used to define thermal comfort. A machine learning model leveraging historical smart Wi-Fi thermostat data and outdoor temperature is trained to predict indoor temperature. A Long Short-Term-Memory neural network algorithm …


Hermeneutics Of Hate: How Martin Luther's Rhetorical Manipulation Of The Greek Bible Led To His Anti-Judaic Treatise On The Jews And Their Lies, Michael Parrish Dec 2021

Hermeneutics Of Hate: How Martin Luther's Rhetorical Manipulation Of The Greek Bible Led To His Anti-Judaic Treatise On The Jews And Their Lies, Michael Parrish

Electronic Theses and Dissertations, 2020-2023

Though lauded as a Protestant hero, it is impossible to read Martin Luther's On the Jews and Their Lies and not think about the numerous acts of violence inspired by his commentary. Luther argues that his anti-Judaic treatise is simply reiterating the Greek Bible (the New Testament) and anyone who reads the Greek Bible would come to the same conclusion. This thesis argues that Luther adopted a hermeneutical Jew from theologians and the Greek Bible before him to create his own hermeneutics that demonized the European Jewish population with devastating consequence. Though much of the Greek Bible was part of …


(R1887) Inferring Trends Of Point Processes From Non-Iid Samples, Bruno Appolloni Dec 2021

(R1887) Inferring Trends Of Point Processes From Non-Iid Samples, Bruno Appolloni

Applications and Applied Mathematics: An International Journal (AAM)

We discuss unprecedented, albeit rudimentary, tools to infer the evolution of a point process where the available samples are both truncated and non independently drawn. To achieve this goal, we lay in an intermediate domain between probability models and fuzzy sets, still maintaining probabilistic features of the employed statistics as the reference KPI of the tools. The overall strategy is to frame the problem within the Algorithmic Inference framework and use a sort of kernel trick to distort the seeds of the observed variable so as to render them an iid sample of a random variable in a proper feature …


We're All Originalists Now… Or Are We?: Bostock's Misperceived Quest To Distinguish Title Vii's Meaning From The Public's Expectations, Steven Semeraro Dec 2021

We're All Originalists Now… Or Are We?: Bostock's Misperceived Quest To Distinguish Title Vii's Meaning From The Public's Expectations, Steven Semeraro

Hofstra Law Review

Two principal tenets underlie originalism-textualism: First, judicial interpreters of a statute should not use modern values to supplant original meaning because the law should change only through democratic processes. Second, original meaning is limited to the intersubjective original understanding that a reasonable reader would draw from a statute’s text. Meaning does not include anyone’s extratextual subjective expectations about how a statute should apply.

The divided Bostock Court’s decision that Title VII prohibits sexual orientation and gender identity discrimination reveals a contradiction between originalism-textualisms dual tenets. The mid-1960s public’s expectations about how Title VII would apply to sexual orientation and gender …


4d Ex Vivo Crispr/Cas9 Whole-Genome Screen To Identify Genes Regulating Lung Cancer Metastasis, Alexandria Plumer Dec 2021

4d Ex Vivo Crispr/Cas9 Whole-Genome Screen To Identify Genes Regulating Lung Cancer Metastasis, Alexandria Plumer

Dissertations and Theses (Open Access)

Metastatic lung cancer has a 5-year survival rate of 5%. Lung cancers tend to be asymptomatic until late stages, and almost 90% are not diagnosed until they are advanced. Metastases are very rare events, often initiated by a single cell from a primary tumor into a new niche at a distant location. Investigation of the early metastatic process is of urgent need for the development of early diagnostics and targeted therapeutics. We performed a proof-of-concept CRISPR/Cas9 whole genome knockout screen in the A549 lung adenocarcinoma cell line and utilized a novel ex vivo 4D lung metastasis model to find gene …


The Src- And Abl- Dependent Regulation Of Net1a In Breast Cancer, Ashabari Sprenger Dec 2021

The Src- And Abl- Dependent Regulation Of Net1a In Breast Cancer, Ashabari Sprenger

Dissertations and Theses (Open Access)

The neuroepithelial cell transforming gene 1 (Net1) is a RhoA guanine nucleotide exchange factor that promotes cancer cell motility and metastasis. Two isoforms of Net1 exist, Net1 and Net1A, both of which are which sequestered in the nucleus in quiescent cells to prevent aberrant RhoA activation. Many cell motility stimuli drive cytosolic relocalization of Net1A, but mechanisms controlling this event are not fully understood. Here we demonstrate that EGF stimulates Src- and Abl1-dependent phosphorylation of Net1A to promote its cytosolic localization. We find that Abl1 efficiently phosphorylates Net1A on Y373, and that phenylalanine substitution of Y373 prevents Net1A cytosolic localization. …


Electronic Cigarettes’ Health Effects On Young Adults: An Honors Thesis, Miranda Yates Dec 2021

Electronic Cigarettes’ Health Effects On Young Adults: An Honors Thesis, Miranda Yates

Senior Honors Theses

Hon Lik introduced e-cigarette use in 2003 as a “safe alternative” to smoking cigarettes. Unfortunately, this message has been misinterpreted to mean that e-cigarette use is “harmless”. Recent studies have linked e-cigarette use to adverse health effects involving injury to the heart and lungs. Cigarette smokers using e-cigarettes to quit smoking and reduce second-hand smoke are being exposed to unregulated and potentially harmful chemicals. Teens who may never have considered cigarette smoking have been led to believe that e-cigarette use is safe and non-addictive. However, most e-cigarettes contain nicotine and unsuspecting teens are becoming addicted to this “fun” behavior. This …


Perceptions Of Risk For Covid-19 Among Individuals With Chronic Diseases And Stakeholders In Central Appalachia, Manik Ahuja, Hadii M. Mamudu, Florence M. Weierbach, Karilynn Dowling-Mcclay, David W. Stewart, Manul Awasthi, Timir K. Paul Dec 2021

Perceptions Of Risk For Covid-19 Among Individuals With Chronic Diseases And Stakeholders In Central Appalachia, Manik Ahuja, Hadii M. Mamudu, Florence M. Weierbach, Karilynn Dowling-Mcclay, David W. Stewart, Manul Awasthi, Timir K. Paul

ETSU Faculty Works

Coronavirus disease 2019 (COVID-19) pandemic is rapidly evolving and is a serious public health threat worldwide. Timely and effective control of the pandemic is highly dependent on preventive approaches. Perception of risk is a major determinant of health behavior. The current study explores the association between actual risk and perceived risk for one’s self, family/friends and friends, and community. A questionnaire was administered to participants in Central Appalachia (n = 102). The actual risk was based on the number of chronic conditions of the following conditions: hypertension, heart disease, cancer, diabetes, and chronic obstructive pulmonary disease. Participants were also queried …