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Nanoparticle T Cell Engagers For The Treatment Of Acute Myeloid Leukemia, Kinan Alhallak, Jennifer Sun, Barbara Muz, Amanda Jeske, Jessica Yavner, Hannah Bash, Chaelee Park, Berit Lubben, Ola Adebayo, Samuel Achilefu, John F Dipersio, Abdel Kareem Azab

2020-Current year OA Pubs

Acute myeloid leukemia (AML) is the most common type of leukemia and has a 5-year survival rate of 25%. The standard-of-care for AML has not changed in the past few decades. Promising immunotherapy options are being developed for the treatment of AML; yet, these regimens require highly laborious and sophisticated techniques. We create nanoTCEs using liposomes conjugated to monoclonal antibodies to enable specific binding. We also recreate the bone marrow niche using our 3D culture system and use immunocompromised mice to enable use of human AML and T cells with nanoTCEs. We show that CD33 is ubiquitously present on AML …

Session 2b: Groundwater And Karst, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• In Situ 3D Electrical Resistivity Method for Understanding Water Dynamics in Shallow Karst Features*
• Identifying the Intersection of Contaminated Karst Water and Off-the-Grid Communities in Southcentral Kentucky Using GIS*
• Groundwater Characterization: How Much Data is Enough?
• Examining Hydrogeological Dynamics of Baselevel and Reverse Flow of the Green River and Major Springs of Mammoth Cave, Kentucky*
• Soil Moisture Micronet in the Daniel Boone National Forest

Session 1: Water Research: Impacting The Lives Of Kentuckians, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• Investigation and Remediation of an Urban Karst Groundwater Gasoline Leak at Lost River Cave, Bowling Green, Kentucky
• Spatial and Seasonal Variation in Concentrations of Disinfection Byproducts in the Public Drinking Water System of Martin County, Kentucky
• Farmer to Farmer: Virtual Shop Talks
• Solutions Begin with Understanding: Off-the-Grid Communities and Contaminated Karst Groundwater in Southcentral Kentucky*

Human Microglia Extensively Reconstitute In Humanized-Blt Mice With Human Interleukin-34 Transgene And Support Hiv-1 Brain Infection, Jianshui Zhang, Saroj Chandra Lohani, Yilun Cheng, Tao Wang, Lili Guo, Woong-Ki Kim, Santhi Gorantla, Qingsheng Li

School of Biological Sciences: Faculty Publications

Humanized bone marrow-liver-thymic (hu-BLT) mice develop a functional immune system in periphery, nevertheless, have a limited reconstitution of human myeloid cells, especially microglia, in CNS. Further, whether bone marrow derived hematopoietic stem and progenitor cells (HSPCs) can enter the brain and differentiate into microglia in adults remains controversial. To close these gaps, in this study we unambiguously demonstrated that human microglia in CNS were extensively reconstituted in adult NOG mice with human interleukin-34 transgene (hIL34 Tg) from circulating CD34+ HSPCs, nonetheless not in hu-BLT NOG mice, providing strong evidence that human CD34+ HSPCs can enter adult brain and differentiate into …

Recruitment Patterns Of The Fouling Community On Eelgrass In Long Island Sound, Diana Lancaster

Department of Marine Sciences

Abstract The seagrass Zostera marina (eelgrass) is typically found in shallow protected areas of portions of eastern Long Island Sound (LIS). Although the species and its associated ecosystem have been well studied in many places, work in LIS has been limited. A field study was conducted to assess the fouling communities associated with eelgrass beds around Pine Island, in eastern LIS. Samples were collected from four sites between July and October, 2011. A total of 15 species of fouling organisms were found on eelgrass leaves throughout the study period. Recruitment patterns varied spatially and temporally. Differences in the composition of …

Proceedings Of 2021 Kentucky Water Resources Annual Symposium, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

This symposium was planned and conducted as a part of the state water resources research institute annual program that is supported by Grant/Cooperative Agreement Number G20AS00025 from the United States Geological Survey (USGS). The contents of this proceedings document and the views and conclusions presented at the symposium are solely the responsibility of the individual authors and presenters and do not represent the official views of the USGS or of the symposium organizers and sponsors. This publication is produced with the understanding that the United States Government is authorized to reproduce and distribute reprints for government purposes. Mention of trade …

Mapping The Research Output Of “Istl” (2010-2020): A Single Journal Scientometric Study, Dr Arup Kumar Mondal Librarian

Library Philosophy and Practice (e-journal)

The present study aimed at finding out the research output of Issues in Science and Technology Librarianship (ISTL) during the period 2010-2020 through the scientometric analysis technique. For the analysis of the study, a total no of 35 issues of "ISTL Journal" published during the year 2010 to 2020 have been taken up for evaluation. After deep analysis, it is found that most of the articles in 130(42%) of the journals are Referred Articles (RA). In the journal, during the period a maximum number of 30(13.4%) articles were published in 2010 followed by 2015 and 2011. The degree of collaboration …

The Nuances Of “Tag-Gag” Laws, Jareb Gleckel

Nebraska Law Bulletin (Selected Issues)

This Essay addresses what I have elsewhere called “Tag-Gag” Laws—laws that regulate and restrict how companies can label and advertise plant-based meat products. Plant-based meat is food made entirely from plants that replicates the taste and texture of animal meat. As plant-based meat sales have grown exponentially in recent years, increasing numbers of states have passed Tag-Gag laws; companies selling plant-based meat, in turn, have challenged these laws in court. When covering these lawsuits, the media often (and understandably) lumps them altogether. If a plant-based company wins a preliminary injunction against a state law, it is viewed as a victory …

Spartan Daily, September 13, 2021, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2021

Volume 157, Issue 10

Cseas Weekly Bulletin (September 13, 2021), Center For Southeast Asian Studies

CSEAS Bulletin

No abstract provided.

Functional Organization Of Frontoparietal Cortex In The Marmoset Investigated With Awake Resting-State Fmri, Yuki Hori, Justine C. Cléry, David J. Schaeffer, Ravi S. Menon, Stefan Everling

Brain and Mind Institute Researchers' Publications

Frontoparietal networks contribute to complex cognitive functions in humans and macaques, such as working memory, attention, task-switching, response suppression, grasping, reaching, and eye movement control. However, there has been no comprehensive examination of the functional organization of frontoparietal networks using functional magnetic resonance imaging in the New World common marmoset monkey (Callithrix jacchus), which is now widely recognized as a powerful nonhuman primate experimental animal. In this study, we employed hierarchical clustering of interareal blood oxygen level-dependent signals to investigate the hypothesis that the organization of the frontoparietal cortex in the marmoset follows the organizational principles of the macaque frontoparietal …

The Utah Statesman, September 13, 2021, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Antimicrobial Properties Of Tomato Leaves, Stems, And Fruit And Their Relationship To Chemical Composition, Christina C. Tam, Kevin Nguyen, Daniel Nguyen, Sabrina Hamada, Okhun Kwon, Irene Kuang, Steven Gong, Sydney Escobar, Max Liu, Jihwan Kim, Tiffany Hou, Justin Tam, Luisa W. Cheng, Jong H. Kim, Kirkwood M. Land, Mendel Friedman

Pacific Faculty Work

Background: We previously reported that the tomato glycoalkaloid tomatine inhibited the growth of Trichomonas vaginalis strain G3, Tritrichomonas foetus strain D1, and Tritrichomonas foetus-like strain C1 that cause disease in humans and farm and domesticated animals. The increasing prevalence of antibiotic resistance requires development of new tools to enhance or replace medicinal antibiotics. Methods: Wild tomato plants were harvested and divided into leaves, stems, and fruit of different colors: green, yellow, and red. Samples were freeze dried and ground with a handheld mill. The resulting powders were evaluated for their potential anti-microbial effects on protozoan parasites, bacteria, and fungi. A …

Spasmolytic Effect Of Grewia Asiatica Fruit Extract On Isolated Smooth Muscles Is Mediated Via Multiple Pathways, Muhammad Nabeel Ghayur, Saeed Ahmad, Anwarul Hassan Gilani

Department of Biological & Biomedical Sciences

Background: Grewia asiatica Linn, or phalsa, is a commonly consumed fruit in Pakistan. The fruit is employed in the traditional medicine practice of Pakistan as a smooth muscle relaxant in different gastrointestinal (GI) and cardiovascular diseases. In this investigation, we show the antispasmodic and vasorelaxant actions of Grewia asiatica fruit extract.
Methods: A 70% methanolic crude extract of the plant material was prepared (Ga.Cr). Different isolated GI tissue preparations and endothelium-intact aortas from rats were utilized to observe the pharmacological actions of the extract.
Results: Ga.Cr, in increasing concentrations, inhibited the spontaneously contracting rabbit jejunum. In an effort to determine …

Daily Eastern News: September 13, 2021, Eastern Illinois University

September

No abstract provided.

Early Functional And Cognitive Declines Measured By Auditory-Evoked Cortical Potentials In Mice With Alzheimer’S Disease, Ling Mei, Li-Man Liu, Kaitian Chen, Hong-Bo Zhao

Otolaryngology--Head & Neck Surgery Faculty Publications

Alzheimer’s disease (AD) is characterized by a progressive loss of memory and cognitive decline. However, the assessment of AD-associated functional and cognitive changes is still a big challenge. Auditory-evoked cortical potential (AECP) is an event-related potential reflecting not only neural activation in the auditory cortex (AC) but also cognitive activity in the brain. In this study, we used the subdermal needle electrodes with the same electrode setting as the auditory brainstem response (ABR) recording and recorded AECP in normal aging CBA/CaJ mice and APP/PS1 AD mice. AECP in mice usually appeared as three positive peaks, i.e., P1, P2, and P3, …

Mitonuclear Mismatch Is Associated With Increased Male Frequency, Outcrossing, And Male Sperm Size In Experimentally-Evolved C. Elegans, Brent William Bever

Dissertations and Theses

We provide the first controlled study of how male frequencies and rates of outcrossing evolve in response to mitonuclear mismatch by allowing replicate lineages of C. elegans nematodes containing either mitochondrial or nuclear mutations of electron transport chain (ETC) genes to evolve under three sexual systems: facultatively outcrossing (wildtype), obligately selfing, and obligately outcrossing. In partial support of a tenet of the mitonuclear sex hypothesis, which predicts that outcrossing will be favored in cases of mitonuclear mismatch, we found evolution of increased male frequency in at least one replicate line of all four ETC mutant backgrounds tested--nuclear isp-1, mitochondrial …

Development Of Predictive Equations For Thermal Conductivity Of Compost Bedding, Flávio A. Damasceno, Joseph L. Taraba, George B. Day V, Randi A. Black, Jeffrey M. Bewley, Tales J. Fernandes, Carlos E. A. Oliveira, Rafaella R. Andrade, Matteo Barbari, Patrícia F. P. Ferraz, Lorenzo Leso

Biosystems and Agricultural Engineering Faculty Publications

Among animal facilities, compost-bedded pack (CBP) barns have attracted a lot of attention from milk producers and the scientific community. Systematic investigation of the main thermal properties utilizing sawdust in CBP barns is of environmental and economic relevance. In this paper, the aim was to (a) develop predictive equations for the thermal conductivity (k) of compost bedding as a function of moisture content (MC), the degree of compaction (DC_o), and particle size (PS); and (b) investigate the links between k and depth within bedding material. Samples of compost bedding materials were collected from 42 commercial CBP …

Holding Close Both The Wonder And The Wounds, Kevin Timpe

University Faculty Publications and Creative Works

Brian Brock’s recent Wondrously Wounded is a welcome addition to the growing theology of disability literature. Despite its many virtues, I think Wondrously Wounded runs the risk of distorting the Church’s identity with regard to how it has responded to disability. Drawing on Hilde Lindemann’s work on ‘holding’ and ‘letting go’ of identities, I try to strengthen Brock’s call for the Church. Our collective work toward the realization of the gospel requires that together we hold the Church’s wounds, and not just its wonders, as part of the narrative we recount.

Ankyrin-Dependent Na+ Channel Clustering Prevents Neuromuscular Synapse Fatigue, Chuansheng Zhang, Abhijeet Joshi, Yanhong Liu, Ozlem Sert, Seth G Haddix, Lindsay H Teliska, Anne Rasband, George G Rodney, Matthew N Rasband

Faculty, Staff and Students Publications

Skeletal muscle contraction depends on activation of clustered acetylcholine receptors (AchRs) and muscle-specific Na+ channels (Nav1.4). Some Nav1.4 channels are highly enriched at the neuromuscular junction (NMJ) and their clustering is thought to be essential for effective muscle excitation. However, this has not been experimentally tested, and how NMJ Na+ channels are clustered is unknown. Here, using muscle-specific AnkyrinR, AnkyrinB, and AnkyrinG single, double, and triple-conditional knockout mice we show that Nav1.4 channels fail to cluster only after deletion of all three ankyrins. Remarkably, ankyrin-deficient muscles have normal NMJ morphology, AchR clustering, sarcolemmal levels of Nav1.4, and muscle force, and …

Evidence For Involvement Of Non‐Classical Pathways In The Protection From Uv‐Induced Dna Damage By Vitamin D‐Related Compounds, Warusavithana Gunawardena Manori De Silva, Jeremy Zhuo Ru Han, Chen Yang, Wannit Tongkao‐On, Bianca Yuko Mccarthy, Furkan Akif Ince, Andrew J A Holland, Robert Charles Tuckey, Andrzej T Slominski, Myriam Abboud, Katie Marie Dixon, Mark Stephen Rybchyn, Rebecca Sara Mason

All Works

The vitamin D hormone, 1,25dihydroxyvitamin D3 (1,25(OH)2D3), and related compounds derived from vitamin D3 or lumisterol as a result of metabolism via the enzyme CYP11A1, have been shown, when applied 24 hours before or immediately after UV irradiation, to protect human skin cells and skin from DNA damage due to UV exposure, by reducing both cyclobutane pyrimidine dimers (CPD) and oxidative damage in the form of 8‐oxo‐7,8‐dihydro‐2’‐ deoxyguanosine (8‐OHdG). We now report that knockdown of either the vitamin D receptor or the endoplasmic reticulum protein ERp57 by siRNA abolished the reductions in UV‐induced DNA damage with 20‐hydroxyvitamin D3 or 24‐hydroxylumisterol3, …

Hiring Student Graphic Designers: Benefits, Challenges, And Lessons Learned, Jamie Hazlitt, John Jackson

Librarian Publications & Presentations

No abstract provided.

Emergency Medicine Shift Factors Causing The Most Stress Among Emergency Medicine Residents, Mohamad Moussa, Kristen Hayden, Chia-Hao Shih, Sadik Khuder, Zayd Safadi, Connor Parsell

Journal of Wellness

Introduction: Past studies demonstrate that stress and anxiety affect emergency medicine physicians, but the causal factors identified are usually from sources outside the work shift. We attempt to show the relationship between intrinsic factors of a work shift and anxiety perceived by residents, while also examining differing gender responses.

Methods: In 2018, a cross-sectional survey of emergency medicine residents in the United States was distributed anonymously through the Emergency Medicine Residents Association. The survey consisted of demographic questions, novel questions identifying intrinsic factors, and the Generalized Anxiety Disorder 7-item (GAD-7) scale. Spearman correlation, independent t-test, and multivariate analysis of variance …

#Golead Newsletter, Georgia Southern University

#GoLead Newsletter (2016-2023)

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A Cognitive Category-Learning Model Of Rule Abstraction, Attention Learning, And Contextual Modulation, René Schlegelmilch, Andy J. Wills, Helversen B Von

School of Psychology

No abstract provided.

Effect Of Defoliation Frequency And Planting Density On Yield And Nutritive Value Of Coursetia Ferruginea (Hbk) Lavin, H. J. Delgado Gómez, R. González Anciani, G. López, D. Urdaneta, L. Ramírez Avilés

IGC Proceedings (1977-2023)

The aim of the present study was to asses the influence of the frequency of defoliation and density of sowing on yield and nutritive value of Coursetia ferruginea. Three defoliation frequencies (6, 8 and 10 weeks) and three densities of planting (1 x 1 m, 1 x 1.5 m and 1 x 2 m) were evaluated. A randomized block design, in a split plot arrangement and four repetitions, was used. Frequency of defoliation has a strong significant (P< 0.01) effect on dry matter (DM) yield (13.6, 18.1 and 27.8 g DM/plant for 6, 8 and 10-week defoliation frequencies), plant height (63.5, 76.6 and 101.2 cm) and plant survival (71, 74 and 86%). Nutritive value was significantly (P< 0.05) affected by the frequency of defoliation. Mineral content was reduced as the defoliation interval increased. Density of planting did not affect (P> 0.05) any of the variables. It is concluded that, C. ferruginea is a forage shrub with potential to improve animal feed …

Leaf Elongation Rate Of Mediterranean And Temperate Tall Fescue Cultivars Under Water Deficit, Silvia G. Assuero, C. Matthew, Mónica G. Agnusdei

IGC Proceedings (1977-2023)

The leaf elongation rate of a temperate (Festuca arundinacea Schreb.) and a Mediterranean (F. arundinacea var. letourneuxiana) tall fescue cultivar in response to water deficit was studied in a glasshouse experiment. Plants of both cultivars were grown in the same containers and received water daily with gradation in intensity of water deficit achieved by varying the daily water ration per container. Leaf elongation rate (LER) was calculated for eight successive subperiods during the application of the water treatments. Under the high temperatures registered in this experiment, the Mediterranean cultivar showed lower LERs and tended to be less …

Prediction Of Herbage Accumulation Of Cynodon Grasses By An Empirical Model Based On Temperature And Daylength, H. R. De Medeiros, Carlos G. S. Pedreira, N. A. Villa Nova, L. G. Barioni, A. C. C. Mello

IGC Proceedings (1977-2023)

The objective of this work was to estimate dry matter production of Cynodon grasses as a function of photothermal units (PU). Total PU values were calculated for the period from February 1 to April 24, 1996, from a location in southeastern Brazil. Regression analysis was run between PU and herbage production from a published data set on five Cynodon cultivars, with an r² of 0.9983. Differences between measured and estimated values were under 5%. Model testing using an independent data set on herbage dry matter production from grazed Cynodon pastures showed an overestimation, probably due to water deficit during …

Geochemistry Of Phosphatic Nodules As A Tool For Understanding Depositional And Taphonomical Settings In A Palaeolithic Cave Site (San Teodoro, Sicily), Gerlando Vita, Vittorio Garilli, Mirko Andrea Vizzini, Renato Giarrusso, Angelo Mulone, Massimiliana Pinto Vraca, Valeria La Parola, Pierluigi Rosina, Laura Bonfiglio, Luca Sineo

International Journal of Speleology

Interpreting depositional settings of cave sites is generally problematic, especially in absence of paleontological/archaeological evidence. This is the case of some deposits at San Teodoro Cave (Sicily), a key site for the Mediterranean Palaeolithic. In a stratigraphic level interrupted by a carbonatic concretion, phosphatic nodules are present only in the part enclosed between the concretion and the cave wall. The discovery of these nodules combined with the punctual lack of fossils had initially suggested an erosion phenomenon and subsequent formation of nodules at a vadose level. Here we show the usefulness of an integrated, geochemical-paleoecological approach in defining stratigraphy and …

Tourisme Intégré Ou Ségrégé À Agadir? Point De Vue D'En Bas, Therese Neuer-Miebach

Dirassat

Integrated tourism or segregation in Agadir?

Viewpoints from below

In the 70s of the 20th century there was a boom in distant travel and mass tourism from Europe to developing countries, here in question Morocco (CI). Speaking of the universe character! and multidisciplinary tourism, capable of animating all economic and commercial sectors and favorable to all areas of human life, it was attributed, so to speak, a "magical power" at that time, a status intangible to any criticism.Up to this time, there exists a lot of advertising material (launched by tourism promoters) seeking to gain the confidence of investors and …