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Spartan Daily, September 14, 2021, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2021

Volume 157, Issue 11

Fr. Ferree Annual Lecture: Being Where We Are: The Land, Catholic Scholarship And Anti-Racism, Kelly S. Johnson, College Of Arts And Sciences, Fr. William J. Ferree Chair Of Social Justice

Documents, Events, Reports, and Promotional Materials of the Ferree Chair of Social Justice

No abstract provided.

Healthcare Providers' And Community Leaders' Knowledge And Perceptions Of Neurocysticercosis In Rural Bolivia, Amy J. Alberts

Dissertations

Neurocysticercosis (NCC) is a preventable infectious disease that is considered a major cause of epilepsy in developing nations. Bolivia is one of the least developed nations in Latin America and in rural Bolivia persons with epilepsy (PWE) go largely without treatment. Epilepsy is a devastating disease that has the capacity to significantly decrease the quality of life, not only for PWE, but for their families as well. The development and implementation of a self-sustainable program for the prevention and treatment of NCC and the consistent treatment of epilepsy is essential. However, research on epilepsy and NCC in Bolivia, whether in …

Engineered Clostridium Botulinum Toxin Adapted To Deliver Molecules Into Selected Cells, Benjamin J. Pavlik, Paul Blum, Kevin Van Cott

School of Biological Sciences: Faculty Publications

An engineered payload - delivery system includes a target cell binding unit, covalently bound to a pore forming unit, and a payload portion adapted with a region capable of non-covalently binding to the pore forming unit. The pore forming unit is derived from a particular sub-serotype of Clostridium toxin, while the payload region is derived from a different sub-serotype of Clostridium toxin. The disclosed chimeric protein-based composition is capable of specifically delivering payload to neural cells.

Brexanolone, A GabaA Modulator, In The Treatment Of Postpartum Depression In Adults: A Comprehensive Review, Amber N. Edinoff, Amira S. Odisho, Kendall Lewis, Amir Kaskas, Grace Hunt, Elyse M. Cornett, Alan David Kaye, Adam M. Kaye, John Morgan, P. Scott Barrilleaux, David Lewis, Omar Viswanath, Ivan Urits

School of Pharmacy Faculty Articles

Postpartum depression (PPD) is one of the three major categories on the spectrum of postpartum psychiatric syndromes. Postpartum psychiatric syndromes are classified as either postpartum blues, postpartum depression, or postpartum psychosis. Postpartum depression is important to recognize clinically because of the effect it can have on the mother-child bond. The neurosteroid allopregnanolone, a progesterone derivative, is important for its role in positively modulating GABAA receptors. GABA-mediated signaling has been previously implicated in major depressive disorder. Allopregnanolone-mediated signaling has been identified as an important therapeutic target. Treatment with an allopregnanolone-analog, brexanolone, has been shown to improve depression scores in trials for …

Embryonic And Neonatal Mouse Cochleae Are Susceptible To Zika Virus Infection., Vidhya Munnamalai, Nabilah H Sammudin, Caryl A Young, Ankita Thawani, Richard J Kuhn, Donna M Fekete

Faculty Research 2021

Congenital Zika Syndrome (CZS) is caused by vertical transmission of Zika virus (ZIKV) to the gestating human fetus. A subset of CZS microcephalic infants present with reduced otoacoustic emissions; this test screens for hearing loss originating in the cochlea. This observation leads to the question of whether mammalian cochlear tissues are susceptible to infection by ZIKV during development. To address this question using a mouse model, the sensory cochlea was explanted at proliferative, newly post-mitotic or maturing stages. ZIKV was added for the first 24 h and organs cultured for up to 6 days to allow for cell differentiation. Results …

Adapting: A Chinese Philosophy Of Action, Mercedes Valmisa

Gettysburg College Faculty Books

If you are from the West, it is likely that you normally assume that you are a subject who relates to objects and other subjects through actions that spring purely from your own intentions and will. Chinese philosophers, however, show how mistaken this conception of action is. Philosophy of action in Classical China is radically different from its counterpart in the Western philosophical narrative. While the latter usually assumes we are discrete individual subjects with the ability to act or to effect change, Classical Chinese philosophers theorize that human life is embedded in endless networks of relationships with other entities, …

Proteoglycan-4 Is An Essential Regulator Of Synovial Macrophage Polarization And Inflammatory Macrophage Joint Infiltration, Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Tannin A. Schmidt, Jennifer Totonchy, Khaled A. Elsaid

Pharmacy Faculty Articles and Research

Background

Synovial macrophages perform a multitude of functions that include clearance of cell debris and foreign bodies, tissue immune surveillance, and resolution of inflammation. The functional diversity of macrophages is enabled by distinct subpopulations that express unique surface markers. Proteoglycan-4 (PRG4) is an important regulator of synovial hyperplasia and fibrotic remodeling, and the involvement of macrophages in PRG4’s synovial role is yet to be defined. Our objectives were to study the PRG4’s importance to macrophage homeostatic regulation in the synovium and infiltration of pro-inflammatory macrophages in acute synovitis and investigate whether macrophages mediated synovial fibrosis in Prg4 gene-trap (Prg4 …

Two Souls On A Shore, Geoffrey Reiter

The Mythic Circle

The elf and the Kuparean man were hungry as they walked along the shore of the island. They did not remain at the rock-choked shallows that had disemboweled their trireme.

The Stable Keeper's Son: A Fairy Tale, Wesley Young

The Mythic Circle

Malkin’s riders were venturing farther and farther across the border—nearly, the scouts reported, to the River Sils, which was the easternmost edge of the dominion of Welborne. The King of Welborne spent much time in council, listening to the varied advice of the elders.

Mythic Circle #43, The Editors

The Mythic Circle

Is it just us, or was 2020-2021 the worst year of the past hundred years? Infections, deaths, lockdowns, and quarantines too long for human endurance just kept on keeping on, intensified by squabbles between proponents of collective health measures (masks, vaccines, social distancing) on one side and of individual personal liberties, regardless of the social and health impact, on the other. But through it all, artists continued to think, dream, and produce new work.

Tricked By The Queen Of Fey, Ella Wallsworth-Bell

The Mythic Circle

Before going to the pub, I take a quick stroll to pluck up courage. Turn along the lane out of the village, my smart shoes softly tap-tapping on the tarmac. A few early stars shine bright in the clear autumn sky and my stomach does somersaults.

Alrond And The Magic Fox, Evgeny A. Khvalkov

The Mythic Circle

Have you heard the story of Alrond and the magic fox? I can tell it to you. After all, magic foxes still live in some corners of the world to this day. It is almost impossible to catch them because they are very strong in magic.

The Little Wild, Julian Grant

The Mythic Circle

The “Little Wild” is what she called it—and it shall be ours forever. We had bought the farmhouse when we finally had had enough of the city (Poppy agreed, the city had become too dangerous and noisy).

Vargar, Andoni Cossio

The Mythic Circle

Squinting my eyes and resuming the frenzied spurring, I headed unflinchingly towards the setting sun. The gap between my steed and the couple of pursuers was widening, we were almost outside their shooting range.

Independence, Dependence, And Intellectual Disability: From Cultural Origins To Useful Application, Scot Danforth

Education Faculty Articles and Research

American government educational policy and leading advocacy groups commonly espouse independence as a primary goal for young people with intellectual disabilities. An extensive philosophical literature of autonomy has focused mostly on analyses of cognition that achieve individual self-governance. But the loosely defined concept of independence used by disability policymakers and advocates provides a more malleable, social understanding that involves someone actively relying on the assistance of others. The purpose of this paper is to examine the cultural, historical origins of the notion of independence for disabled persons through an exploration of the biography of Ed Roberts, the father of the …

Embryonic And Neonatal Mouse Cochleae Are Susceptible To Zika Virus Infection, Vidhya Munnamalai, Nabilah H. Sammudin, Caryl A. Young, Ankita Thawani, Richard J. Kuhn, Donna M. Fekete

Department of Biological Sciences Faculty Publications

Congenital Zika Syndrome (CZS) is caused by vertical transmission of Zika virus (ZIKV) to the gestating human fetus. A subset of CZS microcephalic infants present with reduced otoacoustic emissions; this test screens for hearing loss originating in the cochlea. This observation leads to the question of whether mammalian cochlear tissues are susceptible to infection by ZIKV during development. To address this question using a mouse model, the sensory cochlea was explanted at proliferative, newly post-mitotic or maturing stages. ZIKV was added for the first 24 h and organs cultured for up to 6 days to allow for cell differentiation. Results …

Synergies: University-Museum Collaborations, K. Ren Rende, Stephanie Teeter, Lewis Owen

Teacher Education Faculty Publications

The purpose of this report is to provide documentation of the University-Museums Synergies Initiative between a Department of Marine, Earth, and Atmospheric Sciences and a Museum of Natural Sciences. The goals of this initiative were to 1)identify specific projects and opportunities might be developed to strengthen the collaboration between institutions and 2) gain a better understanding of MEAS researchers’ and Museum employees' perspectives on university-museum partnerships.

Hearing Hoofbeats? Think Head And Neck Trauma: A 10-Year Ntdb Analysis Of Equestrian-Related Trauma In The Usa, Kevin Mutore, Jiyun Lim, Demba Fofana, Annelyn Torres-Reveron, Jeffrey Skubic

MEDI 9331 Scholarly Activities Clinical Years

Objective

There is a paucity of evidence about traumatic injuries and their sequelae sustained due to equestrian injuries nationally.

Methods

Retrospective study analyzing National Trauma Data Bank data from 2007 to 2016. Variables collected included age, sex, race, payer status, Injury Severity Score (ISS), hospital length of stay, Glasgow Coma Scale, systolic blood pressure (SBP) at presentation, discharge disposition, and mortality. Patient data were analyzed by anatomic region.

Results

The most frequent type of injury was in the thorax, but head and neck injuries produced the highest mortality. Increased ISS and an SBP of less than 90 mm Hg were …

Intestinal Antiviral Signaling Is Controlled By Autophagy Gene Epg5 Independent Of The Microbiota, Sanghyun Lee, Gowri Kalugotla, Harshad Ingle, Rachel Rodgers, Yating Wang, Yuhao Li, Nicolette R Borella, Hongju Deng, Lindsay Droit, Ryan Hill, Stefan T Peterson, Chandni Desai, Dylan Lawrence, Megan T Baldridge, Et Al

Open Access Publications

Mutations in the macroautophagy/autophagy gene

Evaluation Of 3,3′-Triazolyl Biisoquinoline N,N′-Dioxide Catalysts For Asymmetric Hydrosilylation Of Hydrazones With Trichlorosilane, Shiyu Sun, Changgong Xu, Jamielyn Jarvis, Phillip Nader, Brandon Naumann, Abigail Soliven, Roberto Peverati, Noriko Takenaka

Department of Chemistry Faculty Publications

A new class of axial-chiral biisoquinoline N,N′-dioxides was evaluated as catalysts for the enantioselective hydrosilylation of acyl hydrazones with trichlorosilane. While these catalysts provided poor to moderate reactivity and enantioselectivity, this study represents the first example of the organocatalytic asymmetric reduction of acyl hydrazones. In addition, the structures and energies of two possible diastereomeric catalyst–trichlorosilane complexes (2a–HSiCl₃) were analyzed using density functional theory calculations.

Bridge Inspection And Defect Recognition With Using Impact Echo Data, Probability, And Naive Bayes Classifiers, Faezeh Jafari, Sattar Dorafshan

Civil Engineering Faculty Publications

Interpretation of IE data have been carried out by analyzing IE signals in frequency domain to determine the maximum frequency. However, the current peak frequency method can be inaccurate. The purpose of this research is to introduce features in IE signals that can be used for effective classification and interpretation for bridge deck evaluation through statistical analysis and Naive Bayes classifiers. The dataset contained IE data collected from eight slabs created at Advanced Sensing Technology FAST NDE laboratory (FHWA). A set of statistical features in time domain, normalized peak values, and length of preprocessed signals were used to classify the …

The Relationship Between Rumination And Metacognition : Application Of An Innovative Signal-Detection Approach, Chak Man Tang

Lingnan Theses (MPhil & PhD)

Rumination, a stable vulnerability marker of depression, is associated with lack of affective bias towards positive information due to cognitive control deficit. However, whether ruminators are self-aware remains unknown. Based on the signal-detection approach, the present study examined metacognition associated with rumination. Specifically, metacognitive sensitivity, the extent to which one’s confidence tracks task performance, was measured using the meta-d’ method. In three directed-forgetting memory experiments, the present research examined whether trait rumination (Experiment 1) and interaction between trait rumination and mood state (Experiments 2 and 3) influenced metacognitive sensitivity. Participants were asked to either forget or remember some affective pictures …

Lipid Metabolite Biomarkers In Cardiovascular Disease: Discovery And Biomechanism Translation From Human Studies, Peter Mcgranaghan, Anshul Saxena, Muni Rubens, Emir Veledar

All Publications

Lipids represent a valuable target for metabolomic studies since altered lipid metabolism is known to drive the pathological changes in cardiovascular disease (CVD). Metabolomic technologies give us the ability to measure thousands of metabolites providing us with a metabolic fingerprint of individual patients. Metabolomic studies in humans have supported previous findings into the pathomechanisms of CVD, namely atherosclerosis, apoptosis, inflammation, oxidative stress, and insulin resistance. The most widely studied classes of lipid metabolite biomarkers in CVD are phospholipids, sphingolipids/ceramides, glycolipids, cholesterol esters, fatty acids, and acylcarnitines. Technological advancements have enabled novel strategies to discover individual biomarkers or panels that may …

Exercise Intolerance In Older Adults With Heart Failure With Preserved Ejection Fraction: Jacc State-Of-The-Art Review, Ambarish Pandey, Sanjiv J Shah, Javed Butler, Dean L Kellogg, Gregory D Lewis, Daniel E Forman, Robert J Mentz, Barry A Borlaug, Marc A Simon, Julio A Chirinos, Roger A Fielding, Elena Volpi, Anthony J A Molina, Mark J Haykowsky, Flora Sam, Bret H Goodpaster, Alain G Bertoni, Jamie N Justice, James P White, Jingzhone Ding, Scott L Hummel, Nathan K Lebrasseur, George E Taffet, Iraklis I Pipinos, Dalane Kitzman

Faculty, Staff and Students Publications

Exercise intolerance (EI) is the primary manifestation of chronic heart failure with preserved ejection fraction (HFpEF), the most common form of heart failure among older individuals. The recent recognition that HFpEF is likely a systemic, multiorgan disorder that shares characteristics with other common, difficult-to-treat, aging-related disorders suggests that novel insights may be gained from combining knowledge and concepts from aging and cardiovascular disease disciplines. This state-of-the-art review is based on the outcomes of a National Institute of Aging-sponsored working group meeting on aging and EI in HFpEF. We discuss aging-related and extracardiac contributors to EI in HFpEF and provide the …

Multiplexed Drug-Based Selection And Counterselection Genetic Manipulations In Drosophila, Nick Matinyan, Mansi S Karkhanis, Yezabel Gonzalez, Antrix Jain, Alexander Saltzman, Anna Malovannaya, Alejandro Sarrion-Perdigones, Herman A Dierick, Koen J T Venken

Faculty, Staff and Students Publications

The power of Drosophila melanogaster as a model system relies on tractable germline genetic manipulations. Despite Drosophila's expansive genetics toolbox, such manipulations are still accomplished one change at a time and depend predominantly on phenotypic screening. We describe a drug-based genetic platform consisting of four selection and two counterselection markers, eliminating the need to screen for modified progeny. These markers work reliably individually or in combination to produce specific genetic outcomes. We demonstrate three example applications of multiplexed drug-based genetics by generating (1) transgenic animals, expressing both components of binary overexpression systems in a single transgenesis step; (2) dual selectable …

Improved Gal4 And Tet Off Drivers For C. Elegans Bipartite Expression, Michael Nonet

2020-Current year OA Pubs

The first generation of

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Human Or Robot?: Investigating Voice, Appearance And Gesture Motion Realism Of Conversational Social Agents, Ylva Ferstl, Sean Thomas, Cédric Guiard, Cathy Ennis, Rachel Mcdonnell

Conference papers

Research on creation of virtual humans enables increasing automatization of their behavior, including synthesis of verbal and nonverbal behavior. As the achievable realism of different aspects of agent design evolves asynchronously, it is important to understand if and how divergence in realism between behavioral channels can elicit negative user responses. Specifically, in this work, we investigate the question of whether autonomous virtual agents relying on synthetic text-to-speech voices should portray a corresponding level of realism in the non-verbal channels of motion and visual appearance, or if, alternatively, the best available realism of each channel should be used. In two perceptual …

Nanoparticle T Cell Engagers For The Treatment Of Acute Myeloid Leukemia, Kinan Alhallak, Jennifer Sun, Barbara Muz, Amanda Jeske, Jessica Yavner, Hannah Bash, Chaelee Park, Berit Lubben, Ola Adebayo, Samuel Achilefu, John F Dipersio, Abdel Kareem Azab

2020-Current year OA Pubs

Acute myeloid leukemia (AML) is the most common type of leukemia and has a 5-year survival rate of 25%. The standard-of-care for AML has not changed in the past few decades. Promising immunotherapy options are being developed for the treatment of AML; yet, these regimens require highly laborious and sophisticated techniques. We create nanoTCEs using liposomes conjugated to monoclonal antibodies to enable specific binding. We also recreate the bone marrow niche using our 3D culture system and use immunocompromised mice to enable use of human AML and T cells with nanoTCEs. We show that CD33 is ubiquitously present on AML …