Digital Commons Network^™

Mitochondrial Targeted Antioxidants, Mitoquinone And Skq1, Not Vitamin C, Mitigate Doxorubicin-Induced Damage In H9c2 Myoblast: Pretreatment Vs. Co-Treatment, Brian Sacks, Halil Onal, Rose Martorana, Amogh Sehgal, Amanda Harvey, Catherine Wastella, Hafsa Ahmad, Erin Ross, Adona Pjetergjoka, Sachin Prasad, Robert J. Barsotti, Lindon H. Young, Qian Chen

PCOM Scholarly Works

BACKGROUND: Preconditioning of the heart ameliorates doxorubicin (Dox)-induced cardiotoxicity. We tested whether pretreating cardiomyocytes by mitochondrial-targeted antioxidants, mitoquinone (MitoQ) or SKQ1, would provide better protection against Dox than co-treatment.

METHODS: We investigated the dose-response relationship of MitoQ, SKQ1, and vitamin C on Dox-induced damage on H9c2 cardiomyoblasts when drugs were given concurrently with Dox (e.g., co-treatment) or 24 h prior to Dox (e.g., pretreatment). Moreover, their effects on intracellular and mitochondrial oxidative stress were evaluated by 2,7-dichlorofluorescin diacetate and MitoSOX, respectively.

RESULTS: Dox (0.5-50 μM, n = 6) dose-dependently reduced cell viability. By contrast, co-treatment of MitoQ (0.05-10 μM, n …

Kenyon Collegian - September 16, 2021

The Kenyon Collegian

No abstract provided.

Kentucky Equestrians: Defining Socioeconomic Contexts For Extension Programming, Kimberly I. Tumlin, Karin Pekarchik, Steven Claas

Journal of Extension

Understanding relationships between demographic and economic factors and equestrian participation could improve horse program design. We implemented an online survey that characterized associations of participation in equine activities, socioeconomic factors, and economic factors with age. Seventy-five percent of respondents ride, and 34% are recreational, non-competitive participants. Respondents were mostly female, and many participate in the sport throughout life. Many respondents indicated they overspent on equestrian activities. Horse programs should incorporate information and activities that address issues unique to females, should develop skills required by amateur or recreational riders, and should incorporate information on financial wellness.

2021-09-16 Faculty Senate Meeting Minutes, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate meeting minutes from September 16, 2021.

2021-09-16 Faculty Senate Newsletter, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate newsletter from September 16, 2021.

Blood Biomarkers For Mild Traumatic Brain Injury: A Selective Review Of Unresolved Issues, Daniel B. Hier, Tayo Obafemi-Ajayi, Matthew S. Thimgan, Gayla R. Olbricht, Sima Azizi, Blaine Allen, Bassam A. Hadi, Donald C. Wunsch

Biological Sciences Faculty Research & Creative Works

Background: The use of blood biomarkers after mild traumatic brain injury (mTBI) has been widely studied. We have identified eight unresolved issues related to the use of five commonly investigated blood biomarkers: neurofilament light chain, ubiquitin carboxy-terminal hydrolase-L1, tau, S100B, and glial acidic fibrillary protein. We conducted a focused literature review of unresolved issues in three areas: mode of entry into and exit from the blood, kinetics of blood biomarkers in the blood, and predictive capacity of the blood biomarkers after mTBI.

Findings: Although a disruption of the blood brain barrier has been demonstrated in mild and severe traumatic brain …

Ammonia Losses By Volatilization From Coastcross Pasture Fertilized With Two Nitrogen Sources, H. Cantarella, L. De A. Corrêa, A. C. Primavesi, O. Primavesi, A. R. De Freitas, A. G. Da Silva

IGC Proceedings (1977-2023)

Ammonia losses by volatilization from five rates of urea or ammonium nitrate surfaceapplied to coastcross pasture, grown on a dark red latosol (Hapludox) in São Carlos, SP, Brazil, under tropical altitude climate, were measured. Volatilized ammonia was absorbed in traps placed on soil surface. The mean losses from urea applied after five successive cuttings of the grass were 15, 24, 34, and 40% for N rates of 25, 50, 100 and 200 kg N ha-1 per cutting, respectively.

A Peak Ahead: Taconic And Catskills Cataclysms, Christine Woodside

Appalachia

No abstract provided.

Books And Media

Appalachia

AMC’s Best Day Hikes in the Berkshires by Rene Laubach and John S. Burk. White Mountain Winter Recreation Map and Guide. Best Backcountry Skiing in the Northeast by David Goodman. An Ice Climber’s Guide to Southern New England and Eastern New York by Todd Swain. Black Woman in Green by Gloria D. Brown and Donna L. Sinclair. Black Faces, White Spaces by Carolyn Finney. In Search of Amos Clough by Robert W. Averill. Waymaking: An Anthology of Women’s Adventure Writing, Poetry and Art (edited by Helen Mort et al). Paul Preuss: Lord of the Abyss by David Smart. …

Trail Etiquette 201: A New Code For A Complicated Era, Mike Cherim

Appalachia

White Mountain professional guide Mike Cherim sketches a new guide for giving right-of-way to others in the mountains, post-COVID-19.

Ode To My Father, Who Worked: Memories Of Growing Up In A Land Caretaker's Family, Beaumont Sugar

Appalachia

Beaumont Sugar, a writer and artist, reminisces about growing up in a land caretaker’s family.

Off The Mountain: Strangers Build Community Around A Hiker's Sudden Collapse, Donald Kollisch

Appalachia

Strangers build community around a hiker’s sudden collapse on Mount Madison in the White Mountains of New Hampshire. Told sensitively by his friend and doctor.

Off-Trail At Home: Bushwhacking Around Mount Cardigan, Sandy Stott

Appalachia

Sandy Stott bushwhacks around familiar wilderness areas below Mount Cardigan.

Summer/Fall 2021: Off Trail

Appalachia

Summer/Fall 2021 - Volume LXXII, Number 2 - Issue #252. Off Trail: Trailless tangles, bushwhacking, river crossings, helpful strangers, and more.

Sources And Rates Of Phosphorus In Improving Degraded Pasture In Brazilian West Amazon, Valdinei T. Paulino, N. L. Costa, C. R. Townsend, J. A. Magalhães, R. G. A. Periera

IGC Proceedings (1977-2023)

The effects of phosphorus sources (triple superphosphate – TSP, single superphosphate – SSP and partially acidulated rock phosphate – PARP) and rates (0, 50 and 100 kg/ha of P₂O₅ on dry matter (DM) yields and chemical composition of a degraded Brachiaria brizantha cv. Marandu pasture were evaluated in a cutting trial. Phosphorus fertilization, irrespective of sources and rates, showed an effective agronomic technique for pasture recuperation. The grass DM yields and potassium contents were significantly improved by phosphorus application, while weed DM yields were depressed. Irrespective of sources and rates, crude protein, phosphorus, and calcium contents were …

Epidemiology Of Type 2 Diabetes In The Middle East And North Africa: Challenges And Call For Action, Imad El-Kebbi, Nayda Bidikian, Layal Hneiny, Mona Nasrallah

Faculty Publications

Type 2 diabetes continues to be a serious and highly prevalent public health problem worldwide. In 2019, the highest prevalence of diabetes in the world at 12.2%, with its associated morbidity and mortality, was found in the Middle East and North Africa region. In addition to a genetic predisposition in its population, evidence suggests that obesity, physical inactivity, urbanization, and poor nutritional habits have contributed to the high prevalence of diabetes and prediabetes in the region. These risk factors have also led to an earlier onset of type 2 diabetes among children and adolescents, negatively affecting the productive years of …

We Are...Marshall, September 15, 2021, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Past, Present, Future: Mine Action In Motion, Ambassador Stefano Toscano Ph.D.

The Journal of Conventional Weapons Destruction

The story of mine action is one of an adaptive and solution-oriented sector. Time and again, mine action has developed new approaches, tools, and standards to meet evolving challenges and circumstances at the field level. A strong partnership among all key actors has characterized the sector since its early years and has been instrumental to its agility and evolution.

Mine Action: The Early Years, Ian Mansfield

The Journal of Conventional Weapons Destruction

At the global level, the year 1997 was undoubtably the pinnacle of interest in mine action. This was the year that saw the award of the Nobel Peace Prize to Jody Williams and the International Campaign to Ban Land Mines (ICBL), the tragic death of Diana, Princess of Wales, the opening of the Anti-Personnel Mine Ban Convention (APMBC) for signature in Ottawa, the establishment of the United Nations Mine Action Service (UNMAS) as the UN focal point for mine action, the formation of the Geneva International Centre for Humanitarian Demining (GICHD), the genesis of the Mine Action Support Group (MASG), …

Linking Mine Action And Development: The Case Of Komyshuvakha, Nick Vovk

The Journal of Conventional Weapons Destruction

The protracted crisis in Ukraine raises many developmental, humanitarian, and mine action challenges, and while these are interconnected, the response to them continues to be dichotomous. In part perpetuated by donor preferences and reinforced by technical specialty, humanitarian mine action (HMA) organizations often run parallel to the rest, leaving much of the potential for integration untapped. At the onset of the conflict in 2014, Danish Refugee Council-Danish Demining Group (DRC-DDG) returned to Ukraine and became the first international nongovernmental organization (INGO) to initiate a response to the acute need for HMA in its eastern regions. Throughout, DRC-DDG has been leveraging …

The Journal Of Conventional Weapons Destruction, Issue 25.1, Cisr Jmu

The Journal of Conventional Weapons Destruction

Issue 25.1 of The Journal of Conventional Weapons Destruction. A special double issue celebrating our 25th anniversary

Landmine Clearance And Socioeconomic Development: A Study In Colombia, Oliver Ford, Amazia Zargarian, Eric Keefer

The Journal of Conventional Weapons Destruction

The HALO Trust (HALO) arrived in Colombia in 2009 and, once accredited, began operations in 2013. HALO is currently the largest civilian humanitarian demining organization in the country, operating in twenty-five municipalities across eight departments.¹ The United States has supported HALO from the outset in Colombia and remains the single biggest donor for demining in the country. In 2019, through U.S. Department of State support, HALO began an innovative study to investigate the causal link between landmine clearance and socioeconomic development in Colombia. The study focused on two municipalities in the south of Antioquia Department—Nariño and La Unión—both of which …

Data-Driven Decision-Making In Southeast Asia, Mikael Bold, David Avenell

The Journal of Conventional Weapons Destruction

Automated management information systems to enhance decision-making abilities are becoming more important today. Funding and resources are scarce, but technological developments are making it possible to conduct sophisticated analyses that will enhance planning and prioritization: doing more with less. Centered around optimization and efficiency, the geographic information system (GIS) tools provided by Esri¹ have been crucial in providing MAG (Mines Advisory Group)with decision-making software.

Assisting Landmine Survivors In Yemen, Elise Becker, Tamara Klingsheim

The Journal of Conventional Weapons Destruction

Over the past ten years, the Marshall Legacy Institute’s (MLI) Mine Victim’s Assistance Program (MVA) in Yemen has helped over 800 male, female, and child landmine survivors in Yemen. MLI and our in-country program partner have worked to identify survivors and provide them with the assistance they require, including prosthetic services, vocational training, and self-employment opportunities, to improve their lives and increase their prospects for a brighter future.

Bringing Up Buddhas: How Mindfulness Can Impact The Next Generation, Alex Tzelnic

Mindfulness Studies Theses

The following presents both a rationale paper and a creative thesis on the topic of how mindfulness can meaningfully impact the next generation. Given the daunting issues faced by Generation Alpha (those born after 2010), including climate change, social justice, and mental health, understanding how the tool of mindfulness can best support children, as well as inform the caretakers most influential to them such as parents and educators, is crucial.

The following rationale paper outlines how mindfulness can make an impact in the fields of parenting and education, as well as in addressing the pertinent issues mentioned above. In surveying …

Workplace Transformation And Its Tax Compliance Implications, Jay A. Soled

Villanova Law Review (1956 - )

No abstract provided.

A Phytobacterial Tir Domain Effector Manipulates Nad+ To Promote Virulence, Samuel Eastman, Thomas Smith, Mark A. Zaydman, Panya Kim, Samuel Martinez, Neha Damaraju, Aaron Diantonio, Jeffrey Milbrandt, Thomas E. Clemente, James R. Alfano, Ming Guo

Department of Plant Pathology: Faculty Publications

• The Pseudomonas syringae DC3000 type III effector HopAM1 suppresses plant immunity and contains a Toll/interleukin-1 receptor (TIR) domain homologous to immunity-related TIR domains of plant nucleotide-binding leucine-rich repeat receptors that hydrolyze nicotinamide adenine dinucleotide (NAD⁺) and activate immunity. In vitro and in vivo assays were conducted to determine if HopAM1 hydrolyzes NAD⁺ and if the activity is essential for HopAM1’s suppression of plant immunity and contribution to virulence.
• HPLC and LC-MS were utilized to analyze metabolites produced from NAD⁺ by HopAM1 in vitro and in both yeast and plants. Agrobacterium-mediated transient expression and in planta …

Global Population Divergence Of A Cosmopolian Desert Plant, Victor Ryan Alfaro

Biology ETDs

Genetic and phenotypic variation can have different patterns within a species if it has populations with contrasting histories. Populations can have discrete differences that are shaped by different evolutionary scenarios, but within each population, range, or region, traits and association with fitness can also be affected by both edaphic and landscape variation. For my dissertation, I surveyed and experimentally analyzed variation and adaptive potential in Sahara mustard (Brassica tournefortii), a desert annual that has endemic, invasive, and agricultural populations in Africa, Asia, and the Americas. Although my multi-trait analysis generated complex results, my findings can be applied to …

The Use Of Digital Mediums In Expressive Arts Therapy, Katherine Mcadams

Expressive Therapies Capstone Theses

In recent years, there have been considerable advances in technology, which have made digital devices such as computers and cellphones cheaper and more accessible for most Americans. The Pew Research Center (2019) reports that 96% of adult American’s own a cellphone, with 81% owning a smartphone. Usage rates for cellphones and other digital devices amongst children and adolescents are also high with 95% of teens, aged 13-17, report owning a smartphone (Jiang, 2018). Despite these staggering statistics the field of psychology and creative therapies have been slower to adopt and incorporate the use of digital media and technology into the …

Exploring The Circle Of Courage Through Art Therapy: A Literature Review, Kendra Denny Arey

Expressive Therapies Capstone Theses

The Circle of Courage is a framework based on Native principles of childrearing that identifies four major components of healthy human development. When fulfilled, these areas of development provide a strong foundation of resilience to life challenges. However, with youth of today these basic developmental needs are often unmet, leaving them at risk for maladaptive coping strategies, behavioral problems, and other challenges as they transition into adulthood. Although extensive work has been done to adapt the Circle of Courage framework to clinical settings, there is little information on how to help youth engage in a process of self-reflection within this …