Digital Commons Network^™

A Novel Model To Study Adipose-Derived Stem Cell Differentiation, Austin N. Worden

Theses and Dissertations

The use of three-dimensional (3D) culture systems (hydrogels) and adipose-derived stem cells (ADSCs) in regenerative medicine to advance early-stage investigation and modeling of the mechanisms of diseases, treatments, targets, etc. has recently increased. ADSCs, specifically, are utilized due to their innate programming during embryogenesis and in adult tissues in addition to their ability to differentiate into mesodermal, endodermal, and ectodermal cell-specific lineages. Of importance is that these advancements do not involve a model specimen (i.e. mice or rats) and simulate the numerous conflicting signals a migrating cell is exposed to in vivo such as chemokines, extracellular matrix (ECM), growth factors, …

Value Creation Mechanisms In The Contemporary Art Market, Niharika Goel

Theses and Dissertations

As marketing theory has evolved, value co-creation has taken center stage in exchange processes. The goal of this dissertation, situated at the intersection of market systems and the visual art market, is to generate a deeper understand of the fundamentals of value co-creation at the level of practice, in part because the visual art world is organized as a Bourdieusian field of cultural production with its own set of rules, narratives, individuals and institutions. While individuals can effectively position themselves in this field to accumulate social capital, they are inextricably linked to others. Hence, it is imperative to understand the …

The Influence Of Adhd On Concussion In Ncaa College Athletes, Brett Steven Gunn

Theses and Dissertations

Evidence suggests attention deficit/hyperactivity disorder (ADHD) may be associated with an increased incidence of concussion; however, no study has cross-sectionally (Aim 1) and longitudinally (Aim 2) assessed the associations of ADHD with concussion. Additionally, there is reason to expect cognitive alterations following concussion in athletes with ADHD. Further, there is currently no study that has evaluated the influence of common medications often taken to mitigate some symptoms of ADHD, such as methylphenidate and amphetamines. Therefore, we sought to longitudinally assess cognitive profiles (Aim 3) of athletes with ADHD taking medication (ADHD+Rx) and not taking medication (ADHD_uRx) at baseline, 24-48 hours …

Let’S Be Friends: Examining Consumer Brand Relationships Through The Lens Of Brand Personality, Engagement, And Reciprocal Altruism, Daniel D. Haun

Theses and Dissertations

Brands have always exuded personality and status to consumers in order to promote a competent impression and induce positive perceptions and behaviors (Griskevicius, et al., 2007). In order for individuals to identify with brands, the brands must become more personable by consciously embodying a specific personality trait. Research has found that when a brand embodies a personality, there is an associated increase in consumer preference and usage (Sirgy, 1982), purchase choices for that brand (Ha & Janda, 2014; Gordon et al., 2016; Guèvremont & Grohmann, 2013; Swaminathan et al., 2009), and consumer preference and brand loyalty (Louis & Lombart, 2010; …

Assessing Stakeholder Needs And Preferences For Coastal Swimming Advisories In Charleston, South Carolina, Zachary Haynes Hart

Theses and Dissertations

The Beaches Environmental Assessment and Coastal Health (BEACH) Act was established in 2000 to reduce the risk of illness among recreational users of beaches in the United States. Specifically, the Act provides coastal states and territories with annual grants to conduct routine water quality monitoring at beaches and to notify the public when pathogen levels exceed safe thresholds. Many coastal states use beach signs, agency websites, and press releases to notify the public, but a 2011 evaluation of the public notification component of the BEACH Act found that few states are choosing methods based on target audience characteristics and interests. …

Utilization Of Remote Sensing To Analyze Aedes Mosquito Egg Abundance With Combined Weather Variables In Two Southeastern Coastal Cities, Danielle M. Johnson

Theses and Dissertations

Several vector-borne diseases have recently resurfaced, and many have suddenly spread to new areas in the United States (U.S.) due to climate change and tropicalization. Two vectors of public health importance are Aedes aegyptiand Aedes albopictus. The Southeastern region of the U.S. appears to be a preferential ecological niche for both Aedes species. Aedes aegyptiand Aedes albopictus are highly susceptible to environmental conditions, such as humidity, precipitation, temperature. Remote sensing technology has proven to be useful for estimating vector populations. Miami-Dade County is an established hotspot for disease transmission. Charleston County is newly vulnerable due to similar …

Unf Journal Fall 2021, University Of North Florida

UNF Journal

A university periodical for alumni and friends of the University of North Florida.

Variations In Er Stress And Unfolded Protein Response Predict Disease Susceptibility, Youwen Zhang

Theses and Dissertations

Numerous studies linked endoplasmic reticulum (ER) stress and unfolded protein response (UPR) to physiological responses to stress and various human pathologies, including metabolic disorders. Although variability in stress responses among individuals has been widely recognized, how such variations in the UPR affect susceptibility to diseases remains unknown. Using outbred deer mice as a model, we explored the consequences of the differential propensity to UPR at the transcriptomic, cellular, and organismic level.

Initially, we analyzed the correlation between several UPR-related genes in primary fibroblasts, at the whole transcriptome level, after ER stress induction. The analysis of correlated transcripts revealed that their …

The Development Of Novel Cdk8 And Cdk19 Inhibitors And Degraders As Potential Anti-Cancer Agents, Li Zhang

Theses and Dissertations

CDK8 and its homolog CDK19 are essential for transcription regulation and their dysregulation has been identified in numerous diseases, especially in cancers. CDK8 and CDK19 have been implicated in cancer development through their kinase activity and kinase independent functions. Despite the existing CDK8/19 inhibitors, there is still a need to develop novel CDK8/19 inhibitors with improved potency and PK profile. It is also necessary to develop CDK8/19 degraders that are able to eliminate the kinase-independent functions. Although two CDK8-degrading PROteolysis Activating Chimeras (PROTACs) have been reported, they have limited CDK8 degradation efficacy and no effect on CDK19. PROTACs with improved …

Development Of A Cyberinfrastructure For Assessment Of The Lower Rio Grande Valley North And Central Watersheds Characteristics, Linda Navarro, Ahmed Mahmoud, Andrew Ernest, Abdoul Oubeidillah, Jessica Johnstone, Ivan Rene Santos Chavez, Christopher Fuller

Biological and Agricultural Engineering Faculty Publications and Presentations

Lower Laguna Madre (LLM) is designated as an impaired waterway for high concentrations of bacteria and low dissolved oxygen. The main freshwater sources to the LLM flow from the North and Central waterways which are composed of three main waterways: Hidalgo/Willacy Main Drain (HWMD), Raymondville Drain (RVD), and International Boundary & Water Commission North Floodway (IBWCNF) that are not fully characterized. The objective of this study is to perform a watershed characterization to determine the potential pollution sources of each watershed. The watershed characterization was achieved by developing a cyberinfrastructure, and it collects a wide inventory of data to identify …

Introduction, William Cleary C.S.Sp.

Spiritan Horizons

No abstract provided.

Father Alphonse Gilbert (1921-2020): Animated By The Spirit Of God For A Century, Étienne Osty C.S.Sp.

Spiritan Horizons

No abstract provided.

Libermann’S Understanding Of Suffering And The Challenges Of Covid-19 Pandemic In Africa, Kenneth Ofoma C.S.Sp.

Spiritan Horizons

No abstract provided.

Signs & Symbols, Vol. 21, Fall 2021, Illinois State University, Department Of Sociology And Anthropology

Signs & Symbols

Newsletter of the Illinois State University Department of Sociology and Anthropology

Alveolar Socket Healing In 5-Lipoxygenase Knockout Aged Female Mice Treated Or Not With High Dose Of Zoledronic Acid, Ramez H Mahmoud, Claudia C Biguetti, Gustavo B Simionato, Isabela C Custódio, Raquel B P Silva, Marco A H Duarte, Leonardo P Faverani, Edilson Ervolino, Walid D Fakhouri, Mariza A Matsumoto

Faculty, Staff and Student Publications

This study investigated the role 5-lypoxigenase (5-LO) on alveolar socket healing in aged female mice treated with zoledronic acid (ZL). Forty 129/Sv female mice (64-68 weeks old), 20 wild type (WT) and 20 5-LO knockout (5LOKO) were equally distributed according to ZL treatment: WT Control, WT ZL, 5LOKO Control, and 5LOKO ZL. ZL groups were treated with an intraperitoneal injection of 250 µg/Kg of ZL, while controls were treated with saline. Treatments were administered once a week, starting four weeks before surgery for tooth extraction and until 7 and 21 days post-surgery. Mice were euthanized for a comprehensive microscopic analysis …

Fibrin Gel Enhances The Antitumor Effects Of Chimeric Antigen Receptor T Cells In Glioblastoma, Edikan A. Ogunnaike, Alain Valdivia, Mostafa Yazdimamaghani, Ernesto Leon, Seema Nandi, Hannah Hudson, Hongwei Du, Simon Khagi, Zhen Gu, Barbara Savoldo, Frances S. Ligler, Shawn Hingtgen, Gianpietro Dotti

Chemical and Biochemical Engineering Faculty Research & Creative Works

Regional delivery of chimeric antigen receptor (CAR) T cells in glioblastoma represents a rational therapeutic approach as an alternative to intravenous administration to avoid the blood-brain barrier impediment. Here, we developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release. Using a model of subtotal glioblastoma resection, we demonstrated that the fibrin-based gel delivery of CAR-T cells within the surgical cavity enables superior antitumor activity compared to CAR-T cells directly inoculated into the tumor resection cavity.

Self-Adhesive Silicone Microstructures For The Treatment Of Tympanic Membrane Perforations, Gabriela Moreira Lana, Katharina Sorg, Gentiana Ioana Wenzel, Dietmar Hecker, René Hensel, Bernhard Schick, Klaus Kruttwig, Eduard Arzt

Chemical and Biochemical Engineering Faculty Research & Creative Works

Inspired by the gecko foot, polymeric microstructures have demonstrated reliable dry adhesion to both stiff objects and sensitive surfaces such as skin. Microstructured silicone patches are proposed, herein, for the treatment of tympanic membrane perforations with the aim of serving as an alternative for current surgical procedures that require anesthesia and ear canal packing. Sylgard 184 PDMS micropillars of 20 μm in diameter and 60 μm in length are topped by a Soft Skin Adhesive (SSA) MG7-1010 terminal layer, of about 25 μm thickness. The adhesion is evaluated by specially designed tack tests against explanted murine eardrums and, for comparison, …

2021 October, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for October of 2021.

The Public Poster: An Exploration Of Storytelling In Poster Design, Elizabeth Hiler

Theses

Research suggests that it is incredibly difficult for a person to change their mind. Confirmation bias and echo chambers are just a few of the reasons people do not give themselves the opportunity to explore new stories, ideas, beliefs. It is now our challenge to connect with people in unconventional ways and explore storytelling in new spaces to give difficult topics more accessibility to public discourse. The Public Protest Poster can be found at the start of most movements for social and political change by creating a simplified statement with a strong graphic for instant impact. Yet, protest posters rely …

On The Usability (In)Security Of In-App Browsing Interfaces In Mobile Apps, Zicheng Zhang, Daoyuan Wu, Lixiang Li, Debin Gao

Research Collection School Of Computing and Information Systems

Due to the frequent encountering of web URLs in various application scenarios (e.g., chatting and email reading), many mobile apps build their in-app browsing interfaces (IABIs) to provide a seamless user experience. Although this achieves user-friendliness by avoiding the constant switching between the subject app and the system built-in browser apps, we find that IABIs, if not well designed or customized, could result in usability security risks. In this paper, we conduct the first empirical study on the usability (in)security of in-app browsing interfaces in both Android and iOS apps. Specifically, we collect a dataset of 25 high-profile mobile apps …

Factors That Promote Or Predict Infidelity, Bryan Kwok Cheng Choy, Norman P. Li

Research Collection School of Social Sciences

Depending on the theoretical perspective taken (e.g., biological, evolutionary, relationships science, individual differences), different factors can promote or predict infidelity. While each factor may independently contribute to infidelity, it is likely that the occurrence of infidelity is contingent on a multitude of factors.

The Jury Trial Reinvented, Christopher Robertson, Michael Shammas

Faculty Scholarship

The Framers of the Sixth and Seventh Amendments to the United States Constitution recognized that jury trials were essential for maintaining democratic legitimacy and avoiding epistemic crises. As an institution, the jury trial is purpose-built to engage citizens in the process of deliberative, participatory democracy with ground rules. The jury trial provides a carefully constructed setting aimed at sorting truth from falsehood.
/="/">
/="/">Despite its value, the jury trial has been under assault for decades. Concededly, jury trials can sometimes be inefficient, unreliable, unpredictable, and impractical. The COVID–19 pandemic rendered most physical jury trials unworkable but spurred some courts …

Public Health And The Power To Exclude: Immigrant Expulsions At The Border, Sarah R. Sherman-Stokes

Faculty Scholarship

We are presently in the midst of a crisis at the U.S.-Mexico border, as Courts, and indeed the Biden Administration, are struggling to manage thousands of immigrants waiting to seek asylum in the midst of a global pandemic. Beginning in March of 2020, against the advice of public health experts, the U.S. Government closed the southern U.S.-Mexico border, disproportionately impacting would-be asylum seekers from Central America, who are now immediately expelled from the United States should they reach the border under a process known as “Title 42.” Not only do these expulsions lack a legitimate public health rationale, but they …

Settingsorder Article Reprints Open Accessarticle Generation And Characterization Of Human Mesenchymal Stem Cell-Derived Smooth Muscle Cells, Srikanth Sivaraman, Jackson Hedrick, Samia Ismail, Chris Slavin, Raj R. Rao

Biomedical Engineering Faculty Publications and Presentations

Cardiovascular diseases are the leading cause of death worldwide. A completely autologous treatment can be achieved by using elastogenic mesenchymal stem cell (MSC)-derived smooth muscle cells (SMC) at the affected tissue site of vascular diseases such as abdominal aortic aneurysms (AAA). Thus, our work focused on evaluating the efficacy of (a) the combination of various growth factors, (b) different time periods and (c) different MSC lines to determine the treatment combination that generated SMCs that exhibited the greatest elastogenicity among the tested groups using Western blotting and flow cytometry. Additionally, total RNA sequencing was used to confirm that post-differentiation cells …

Illinois State University Annuitants Association Newsletter, Fall 2021, Illinois State University, Annuitants Association

ISUAA News

Illinois State University Annuitants Association newsletter

Dapi Staining And Dna Content Estimation Of Nuclei In Uncultivable Microbial Eukaryotes (Arcellinida And Ciliates), Ketty Munyenyembe, Caitlin Timmons, Agnes K.M. Weiner, Laura A. Katz, Ying Yan

Biological Sciences: Faculty Publications

Though representing a major component of eukaryotic biodiversity, many microbial eukaryotes remain poorly studied, including the focus of the present work, testate amoebae of the order Arcellinida (Amoebozoa) and non-model lineages of ciliates (Alveolata). In particular, knowledge of genome structures and changes in genome content over the often-complex life cycles of these lineages remains enigmatic. However, the limited available knowledge suggests that microbial eukaryotes have the potential to challenge our textbook views on eukaryotic genomes and genome evolution. In this study, we developed protocols for DAPI (4′,6-diamidino-2-phenylindole) staining of Arcellinida nuclei and adapted protocols for ciliates. In addition, image analysis …

Redbird Impact, Vol. 4, No. 2 (Fall 2021), Center For Civic Engagement

Redbird Impact

No abstract provided.

Friends And Foes: Extracellular Vesicles In Aging And Rejuvenation, Brian V Lananna, Shin-Ichiro Imai

2020-Current year OA Pubs

Extracellular vesicles (EVs) are released by many different cell types throughout the body and play a role in a diverse range of biological processes. EVs circulating in blood as well as in other body fluids undergo dramatic alterations over an organism's lifespan that are only beginning to be elucidated. The exact nature of these changes is an area of active and intense investigation, but lacks clear consensus due to the substantial heterogeneity in EV subpopulations and insufficiencies in current technologies. Nonetheless, emerging evidence suggests that EVs regulate systemic aging as well as the pathophysiology of age-related diseases. Here, we review …

Cochlear Inflammaging In Relation To Ion Channels And Mitochondrial Functions, Parveen Bazard, Jennifer Pineros, Robert D. Frisina, Mark A. Bauer, Alejandro A. Acosta, Lauren R. Paganella, Dominika Borakiewicz, Mark Thivierge, Freyda L. Mannering, Xiaoxia Zhu, Bo Ding

Chemical and Biochemical Engineering Faculty Research & Creative Works

The slow accumulation of inflammatory biomarker levels in the body—also known as inflammation—has been linked to a myriad of age-related diseases. Some of these include neurodegenerative conditions such as Parkinson's disease, obesity, type II diabetes, cardiovascular disease, and many others. Though a direct correlation has not been established, research connecting age-related hearing loss (ARHL)—the number one communication disorder and one of the most prevalent neurodegenerative diseases of our aged population—and inflammation has gained interest. Research, thus far, has found that inflammatory markers, such as IL-6 and white blood cells, are associated with ARHL in humans and animals. Moreover, studies investigating …

Bios 6531 - Categorical Data Analysis, Haresh Rochani Dr.

College of Public Health: Faculty Syllabi (2014-2021)

(taken from 2020‑21 Course Catalog): This course introduces statistical methods for analyzing both univariate and multivariate categorical data and count in medical research and other health-related fields. The course will introduce how to distinguish among the different measurement scales, the commonly used statistical probability distribution and inference methods for categorical and count data. Emphasis will be placed on the application of the methodology and computational aspects rather than theory. The students will learn how to apply SAS procedures to data and interpret the results.