Digital Commons Network^™

Plant Extract Of Limonium Gmelinii Attenuates Oxidative Responses In Neurons, Astrocytes, And Cerebral Endothelial Cells In Vitro And Improves Motor Functions Of Rats After Middle Cerebral Artery Occlusion, Tulendy Nurkenov, Andrey Tsoy, Farkhad Olzhayev, Elvira Abzhanova

Faculty and Student Publications

There are numerous publications demonstrating that plant polyphenols can reduce oxi-dative stress and inflammatory processes in the brain. In the present study we have investigated the neuroprotective effect of plant extract isolated from the roots of L. gmelinii since it contains a rich source of polyphenols and other biologically active compounds. We have applied an oxidative and inflammatory model induced by NMDA, H2O2, and TNF‐α in human primary neurons and astrocytes, and mouse cerebral endothelial cell (CECs) line in vitro. The levels of ROS generation, NADPH oxidase activation, P‐selectin expression, and activity of ERK1/2 were evaluated by quan-titative immunofluorescence analysis, …

Criminal Justice Update - November 2021, Patrick Mahoney

Criminal Justice Updates

The Criminal Justice Update is a monthly newsletter created by the Adams County Bar Foundation Fellow providing updates in criminal justice policy coming from Pennsylvania's courts and legislature as well as the US Supreme Court.

Contents:

• Updates from PA Governor's Office (no updates this month)
• Updates from the PA Legislature
• Criminal Law & Procedure
• Updates from the Courts
• U.S. Supreme Court (no updates this month)
• PA Supreme Court: Criminal Law & Procedure
• PA Superior Court: Criminal Law & Procedure

Economic Contribution Of Agriculture And Food To Arkansas’ Gross Domestic Product 1997-2020, Leah English, Jennie Popp, Wayne Miller

AAES Research Reports and Research Bulletins

Agricultural production, processing, and retail industries are major contributors to Arkansas’ GDP. Agriculture contributes to the state economy through direct agricultural production, value-added processing, and agricultural retail activities. The Agriculture and Food Sector, which is comprised of agricultural production, processing, and retail industries, promotes economic strength through various interactions with other industries. The use of non-agricultural goods and services as inputs into the agricultural sector promotes diversified growth in Arkansas’ economy and thus plays a vital role in maintaining economic stability throughout the state. This report 1) compares the relative size of the Agriculture and Food Sector in Arkansas with …

An Analysis Of Companion Animal Tick Encounters As Revealed By Photograph-Based Crowdsourced Data, Heather L. Kopsco, Roland J. Duhaime, Thomas N. Mather

Plant Sciences and Entomology Faculty Publications

Background: Community science is increasingly utilized to track important vectors of companion animal disease, providing a scalable, cost-effective strategy for identifying new foci, changing phenology, and disease prevalence across wide geographies. Objectives: We examined photographs of ticks found attached to predominately dogs and cats reported to a photograph-based tick surveillance program to identify potential areas for improvements in tick prevention education and risk intervention. Methods: We compared estimated days of tick attachment using a Kruskal–Wallis one-way analysis of variance, and a Pearson's chi-square analysis of variance on the number of submissions by host type submitted for each season. Results: The …

Assessing The Impact Of Vaccination On Covid-19 In South Africa Using Mathematical Modeling, Musyoka Kinyili, Justin B. Munyakazi, Abdulaziz Y. A. Mukhtar

Applied Mathematics & Information Sciences

The unexpected continuing mushrooming tendency of the COVID-19 epidemic calls for alarm in the entire globe especially with the cropping up of more divergent contagious variants being witnessed. On top of the many non-pharmaceutical measures put in place for containment of the pandemic, pharmacological measures have been incorporated in the battle against the SARS-CoV-2 especially with the commencement of vaccination in the early December 2020. This study develops a deterministic compartmental model that incorporates vaccination as a measure to combat the spread of COVID-19 epidemic. We use the model particularly to assess the potential impact of vaccination in shattering the …

On Dynamical Analysis Of A Prey-Diseased Predator Model With Refuge In Prey, Srinivasarao Thota, Abayomi Ayoade

Applied Mathematics & Information Sciences

In this paper, we propose a mathematical model of a prey-diseased predator model with refuge in prey system. In other words, a prey-predator model with an infectious disease in the prey population is formulated. This model is constituted by a system of three nonlinear ordinary differential equations of first order, which describe the interaction between the infected prey, non-infected prey and predator. The equilibria of the system are derived and the stability analyses of the disease-free and the endemic equilibria are conducted.

An Application Of The Weibull-Poisson Long-Term Survival Regression Model, Valdemiro Piedade Vigas, Giovana Oliveira Silva, Josmar Mazucheli

Applied Mathematics & Information Sciences

n this paper, we illustrate the applicability of a regression model referring to patients with cutaneous melanoma. The reason for the choice of the dataset is due the disease be responsible for most cases of skin cancer. The proposed regression model is based on the Weibull-Poisson distribution in a structure of long-term modeling, in which the covariates were included in the proportion p of cured via the logistic link function. The motivation to study this distribution is since, in addition to generalizing the Weibull model, which is widely used in several areas of knowledge among them the survival analysis, it …

Fur Trade In Minnesota: The Rise And Fall Of Ojibwe Power, Soraya Keiser

Library Research Prize Student Works

Before any Europeans came to the shores of North America, Native Americans inhabited these lands. They fished the waters, harvested the earth, and hunted the game. Within the large continent, the Great Lakes region was especially abundant, and the Ojibwe tribe lived off the land surrounding Lake Superior and much of northern Minnesota, stretching into present-day Canada (Warren 126). The Ojibwe traded with other tribes “along the waterways of present-day Minnesota and across the Great Lakes for centuries before the arrival of Europeans in the mid-1600s” (“The Fur Trade''). However, with the introduction of European settlers, trade only increased. Ojibwe …

Theory Of Change, Center For Complexity

Horizon 2045

Horizon 2045 (H2045) is a 25-year initiative to end the nuclear weapons century.

We urgently need to manage the intertwined existential risks of the Anthropocene—the geological era that began with the 1945 Trinity Test and is characterized by humankind’s newfound capacity to destroy itself along with all life on the planet.

Recent research has shown that concerns about existential threats have become palpable, as has the desire to solve human-made problems and move to a brighter future. This offers an important opportunity: By considering nuclear weapons in the context of other dangers, we can dismantle conventional wisdom that nuclear weapons …

3d Lidar Scanning Of Urban Forest Structure Using A Consumer Tablet, Gursel Y. Çakir, Christopher J. Post, Elena A. Mikhailova, Mark A. Schlautman

Open Access Publishing Fund

Forest measurements using conventional methods may not capture all the important information required to properly characterize forest structure. The objective of this study was to develop a low-cost alternative method for forest inventory measurements and characterization of forest structure using handheld LiDAR technology. Three-dimensional (3D) maps of trees were obtained using an iPad Pro with a LiDAR sensor. Freely-available software programs, including 3D Forest Software and CloudCompare software, were used to determine tree diameter at breast height (DBH) and distance between trees. The 3D point cloud data obtained from the iPad Pro LiDAR sensor was able to estimate tree DBH …

The Effects Of Pelleted Cannabidiol Supplementation On Heart Rate And Reaction Scores In Horses, Anna L. Draeger, Evan P. Thomas, Kiara A. Jones, Shea Porr

Faculty & Staff Research and Creative Activity

The potential use of cannabidiol (CBD) as a nutraceutical to support improved health and welfare has been of increasing interest. In particular, CBD has been shown to decrease anxiety in humans and small animals. While there is little research published on the effects of CBD supplementation in horses, its use is increasing rapidly. The objective of this study was to determine the effect of feeding a pelleted CBD supplement on equine reactivity and heart rate (HR). Seventeen stock-type geldings were divided into control (CON) or treatment (TRT) groups. The TRT group received 100 mg of CBD once daily. Control horses …

Improving The Child Welfare Workforce Through Training: Common Questions And Evidence-Informed Answers From The Qic-Wd, Quality Improvement Center For Workforce Development

QIC-Tips

Training is often the first intervention child welfare agencies use to address critical workforce development issues. This QIC-Tip aims to answer child welfare agency leaders’ questions about effective training strategies to increase knowledge, enhance skills, and improve job performance. Answers are drawn from the QIC-WD Umbrella Summaries which present a synopsis of the published meta-analyses of specific workforce topics.

What broad-based training approaches can improve employee learning outcomes and job performance?

Coaching uses a structured learning process, over time, to help the learner reach specific goals. Meta-analytic research on the use of professional coaches (not managers or experienced coworkers) …

Evaluating Large Spontaneous Deletions In A Bovine Cell Line Selected For Bovine Viral Diarrhea Virus Resistance, Aspen M. Workman, Michael P. Heaton, Dennis A. Webster, Gregory P. Harhay, Theodore S. Kalbfleisch, Timothy P.L. Smith, Shollie M. Falkenberg, Daniel F. Carlson, Tad S. Sonstegard

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Bovine viral diarrhea virus’s (BVDV) entry into bovine cells involves attachment of virions to cellular receptors, internalization, and pH-dependent fusion with endosomal membranes. The primary host receptor for BVDV is CD46; however, the complete set of host factors required for virus entry is unknown. The Madin-Darby bovine kidney (MDBK) cell line is susceptible to BVDV infection, while a derivative cell line (CRIB) is resistant at the level of virus entry. We performed complete genome sequencing of each to identify genomic variation underlying the resistant phenotype with the aim of identifying host factors essential for BVDV entry. Three large compound deletions …

Mapping The Hidden Diversity Of The Geophagus Sensu Stricto Species Group (Cichlidae: Geophagini) From The Amazon Basin, A. M. Ximenes, P. S. Bittencourt, V. N. Machado, Tomas Hrbek, I. P. Farias

Biology Faculty Research

South American freshwater ichthyofauna is taxonomically the most diverse on the planet, yet its diversity is still vastly underestimated. The Amazon basin alone holds more than half of this diversity. The evidence of this underestimation comes from the backlog of morphologically distinct, yet undescribed forms deposited in museum collections, and from DNA-based inventories which consistently identify large numbers of divergent lineages within even well-studied species groups. In the present study, we investigated lineage diversity within the Geophagus sensu stricto species group. To achieve these objectives, we analyzed 337 individuals sampled from 77 locations within and outside the Amazon basin representing …

Nov2021, Robert Kelly

Robert Kelly Manuscripts

No abstract provided.

The Influence Of Type Of Implicit Ewom On Purchase Intention, Michael H. Starr

Doctor of Business Administration (DBA)

Electronic Word-of-mouth (eWOM) helps shape consumers’ purchasing decisions and companies’ marketing choices. Researchers and practitioners have extensively studied textual or word-based eWOM in online reviews, blogs, e-mails, and product sites. The effect of implicit eWOM, eWOM using paralinguistic cues, on consumer behavior has been infrequently studied even though marketers often seek to use implicit eWOM to influence consumers. On Facebook, the most popular social networking platform in the world, three of the most frequently used forms of implicit eWOM are the emoticon, the emoji, and the GIF. A comparison of the effect of types of implicit eWOM on the purchase …

The Utah Statesman, November 1, 2021, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Ultrasound Regulated Flexible Protein Materials: Fabrication, Structure And Physical-Biological Properties., Bowen Cai, Hanling Gu, Fang Wang, Kyle Printon, Zhenggui Gu, Xiao Hu

College of Science & Mathematics Departmental Research

Ultrasound can be used in the biomaterial field due to its high efficiency, easy operation, no chemical treatment, repeatability and high level of control. In this work, we demonstrated that ultrasound is able to quickly regulate protein structure at the solution assembly stage to obtain the designed properties of protein-based materials. Silk fibroin proteins dissolved in a formic acid-CaCl solution system were treated in an ultrasound with varying times and powers. By altering these variables, the silks physical properties and structures can be fine-tuned and the results were investigated with Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron …

Pseudo-Science And ‘Fake’ News ‘Inventing’ Epidemics And The Police State, Babette Babich

Articles and Chapters in Academic Book Collections

No abstract provided.

Indigenous-Led Conservation Reading List, Megan Youdelis, Kim Tran, Elizabeth Lunstrum

Environmental Studies Program Faculty Publications and Presentations

This list compiles literature relevant to the bourgeoning Indigenous-led conservation movement, be that through Indigenous Protected and Conserved Areas (IPCAs, Canada), Indigenous and Community Conserved Areas (ICCAs, global), or various other forms of Indigenous-led governance or co-governance mechanisms that elevate Indigenous rights, responsibilities, and legal traditions. The introductory Colonial Conservation section is not exhaustive, but rather provides context for the main import of the collection, which is to highlight the possibilities, successes, and challenges associated with decolonizing conservation through Indigenous-led governance. The list is global in scope but has been shaped by the Indigenous Circle of Experts’ (2018) report, We …

“La Justicia Ambiental Es Para Ti Y Para Mí”: Translating Collective Struggles For Environmental And Energy Justice In Puerto Rico’S Jobos Bay Communities, Catalina M. De Onis

University of Montana Staff Publications

Rural, coastal communities in the Jobos Bay region of southeastern Puerto Rico confront disproportionate harms as an energy sacrifice zone. This space is constituted by imported fossil fuel dependency, economic and climate injustices, environmental racism, ecocide, US colonialism and imperialism, neoliberalism, and racial capitalism. In response, many grassroots actors mobilize against the toxic assault on their communities to push for alternatives beyond the suffocating status quo via apoyo mutuo [mutual support]. This survival work and movement building occur literally in “the outdoors” and in other intertwined multispecies environments, challenging narrow, oppressive colonial, and consumerist constructs that reduce “the outdoors” to …

Kentucky Warbler (Vol. 97, No. 4), Kentucky Library Research Collections

The Kentucky Warbler

No abstract provided.

Cetacean Acousticwelfare In Wild And Managed-Care Settings: Gaps And Opportunities, Paige E. Stevens, Heather Hill, Jason N. Bruck

Faculty Publications

Cetaceans are potentially at risk of poor welfare due to the animals’ natural reliance on sound and the persistent nature of anthropogenic noise, especially in the wild. Industrial, commercial, and recreational human activity has expanded across the seas, resulting in a propagation of sound with varying frequency characteristics. In many countries, current regulations are based on the potential to induce hearing loss; however, a more nuanced approach is needed when shaping regulations, due to other non-hearing loss effects including activation of the stress response, acoustic masking, frequency shifts, alterations in behavior, and decreased foraging. Cetaceans in managedcare settings share the …

Embryo Lethality Assay As A Tool For Assessing Virulence Of Isolates From Bacterial Chondronecrosis With Osteomyelitis In Broilers, Nnamdi S. Ekesi, Amer Hasan, Alia Parveen, Abdulkarim Shwani, Douglas D. Rhoads

Cell and Molecular Biology Faculty Publications and Presentations

We used an embryo lethality assay (ELA) to assess virulence for different isolates from cases of bacterial chondronecrosis with osteomyelitis (BCO) in broilers. Lameness is among the most significant animal welfare issues in the poultry industry. Bac-terial infections are a major cause of lameness and different bacterial species have been obtained from lame broilers. Reliable lab-based assays are required to assess relative virulence of bacteria obtained from lame broilers. ELA has been used to assess lethal dosage of Enterococcus faecalis and Enterococcus cecorum. We hypothesized that ELA could substitute for more laborious and costly assessments …

Birds Of A Feather Lockdown Together: Mutual Bird-Human Benefits During A Global Pandemic, Michael Brock, Jacqueline Doremus, Liqing Li

Economics

Feeding backyard wildlife has impure public good characteristics - it provides satisfaction to humans, both private and public, while also improving bird populations. We document a surge in human interest in connecting with wild birds during lockdowns in response to the Covid-19 pandemic. Using an event-study design, we find large increases in bird engagement began soon after the start of the COVID-19 lockdowns in Spring 2020. Responses were stronger for areas with more bird species. Investments appear sustained, beginning first with bird feeders, then seed and finally baths. Beyond bird survival, bird feeding can potentially enhance humans' connection to nature …

U2af1 Is A Haplo-Essential Gene Required For Hematopoietic Cancer Cell Survival In Mice, Brian A Wadugu, Sridhar Nonavinkere Srivatsan, Amanda Heard, Michael O Alberti, Matthew Ndonwi, Jie Liu, Sarah Grieb, Joseph Bradley, Jin Shao, Tanzir Ahmed, Cara L Shirai, Ajay Khanna, Christopher A Miller, Matthew J Walter, Et Al

Open Access Publications

Somatic mutations in the spliceosome gene U2AF1 are common in patients with myelodysplastic syndromes. U2AF1 mutations that code for the most common amino acid substitutions are always heterozygous, and the retained WT allele is expressed, suggesting that mutant hematopoietic cells may require the residual WT allele to be viable. We show that hematopoiesis and RNA splicing in U2af1 heterozygous knockout mice were similar to those in control mice, but that deletion of the WT allele in U2AF1(S34F) heterozygous mutant-expressing hematopoietic cells (i.e., hemizygous mutant) was lethal. These results confirm that U2AF1 mutant hematopoietic cells are dependent on the expression of …

Oxidative Phosphorylation Is A Metabolic Vulnerability In Chemotherapy-Resistant Triple-Negative Breast Cance, Kurt W. Evans, Erkan Yuca, Stephen S. Scott, Ming Zhao, Natalia Paez Arango, Christian X. Cruz Pico, Turcin Saridogan, Maryam Shariati, Caleb Class, Christopher A. Bristow, Christopher P. Vellano, Xiaofeng Zheng, Ana Maria Gonzalez-Angulo, Xiaoping Su, Coya Tapia, Ken Chen, Argun Akcakanat, Bora Lim, Debu Tripathy, Timothy A. Yap, Maria Emilia Di Francesco, Giulio F. Draetta, Philip Jones, Heffernan P. Heffernan, Joseph R. Marszalek, Funda Meric-Bernstam

Scholarship and Professional Work – COPHS

Oxidative phosphorylation (OXPHOS) is an active metabolic pathway in many cancers. RNA from pretreatment biopsies from patients with triple-negative breast cancer (TNBC) who received neoadjuvant chemotherapy demonstrated that the top canonical pathway associated with worse outcome was higher expression of OXPHOS signature. IACS-10759, a novel inhibitor of OXPHOS, stabilized growth in multiple TNBC patient-derived xenografts (PDX). On gene expression profiling, all of the sensitive models displayed a basal-like 1 TNBC subtype. Expression of mitochondrial genes was significantly higher in sensitive PDXs. An in vivo functional genomics screen to identify synthetic lethal targets in tumors treated with IACS-10759 found several potential …

Short-Term Treatment With Multi-Drug Regimens Combining Braf/Mek-Targeted Therapy And Immunotherapy Results In Durable Responses In Braf-Mutated Melanoma, Michael G. White, Robert Szczepaniak Sloane, Russell G. Witt, Alexandre Reuben, Pierre Olivier Gaudreau, Miles C. Andrews, Ningping Feng, Sarah Johnson, Caleb Class, Christopher Bristow, Khalida Wani, Courtney Hudgens, Luigi Nezi, Teresa Manzo, Mariana Pettaccia De Macedo, Jianhua Hu, Richard Davis, Hong Jiang, Peter Prieto, Elizabeth Burton, Patrick Hwu, Hussein Tawbi, Jeffrey Gershenwald, Alexander J. Lazar, Michael T. Tetzlaff, Willem Overwijk, Scott E. Woodman, Zachary A. Cooper, Joseph R. Marszalek, Michael A. Davies, Timothy P. Heffernan, Jennifer A. Wargo

Scholarship and Professional Work – COPHS

Targeted and immunotherapy regimens have revolutionized the treatment of advanced melanoma patients. Despite this, only a subset of patients respond durably. Recently, combination strategies of BRAF/MEK inhibitors with immune checkpoint inhibitor monotherapy (α-CTLA-4 or α-PD-1) have increased the rate of durable responses. Based on evidence from our group and others, these therapies appear synergistic, but at the cost of significant toxicity. We know from other treatment paradigms (e.g. hematologic malignancies) that combination strategies with multi-drug regimens (>4 drugs) are associated with more durable disease control. To better understand the mechanism of these improved outcomes, and to identify and prioritize …

Vulnerability To Substance Abuse: A Consideration Of Allostatic Loading Factors, Laura O'Dell

Departmental Papers (Psych)

No abstract provided.

“La Justicia Ambiental Es Para Ti Y Para Mí”: Translating Collective Struggles For Environmental And Energy Justice In Puerto Rico’S Jobos Bay Communities, Catalina M. De Onis

Environmental Studies Faculty Publications

Rural, coastal communities in the Jobos Bay region of southeastern Puerto Rico confront disproportionate harms as an energy sacrifice zone. This space is constituted by imported fossil fuel dependency, economic and climate injustices, environmental racism, ecocide, US colonialism and imperialism, neoliberalism, and racial capitalism. In response, many grassroots actors mobilize against the toxic assault on their communities to push for alternatives beyond the suffocating status quo via apoyo mutuo [mutual support]. This survival work and movement building occur literally in “the outdoors” and in other intertwined multispecies environments, challenging narrow, oppressive colonial, and consumerist constructs that reduce “the outdoors” to …