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Potentiometric Biosensing Of Ascorbic Acid, Uric Acid, And Cysteine In Microliter Volumes Using Miniaturized Nanoporous Gold Electrodes, Christopher J. Freeman, Borkat Ullah, Md. Shafiul Islam, Maryanne M. Collinson

Chemistry & Biochemistry Faculty Publications

Potentiometric redox sensing is a relatively inexpensive and passive approach to evaluate the overall redox state of complex biological and environmental solutions. The ability to make such measurements in ultra-small volumes using high surface area, nanoporous electrodes is of particular importance as such electrodes can improve the rates of electron transfer and reduce the effects of biofouling on the electrochemical signal. This work focuses on the fabrication of miniaturized nanoporous gold (NPG) electrodes with a high surface area and a small footprint for the potentiometric redox sensing of three biologically relevant redox molecules (ascorbic acid, uric acid, and cysteine) in …

Individual Differences In Social Responsiveness, Social Experiences, And Oxytocin System Genetic Variation In Depression Symptom Severity, Grace Sullivan

Department of Psychology: Dissertations, Theses, and Student Research

Social experiences including discrimination, low social support, and interpersonal conflict are reliable predictors of depression symptom severity (Costello, 1982; Monroe, Rohde, Seeley, & Lewinsohn, 1999; Phifer & Murrell, 1986). However, individual differences may buffer against or exacerbate risk (Pluess & Belsky, 2015). A more holistic and dimensional approach, in line with modern perspectives on mental health (Kircanski, LeMoult, Ordaz, & Gotlib, 2017), requires an investigation of individual differences that moderate associations of positive and negative social experiences with depression symptom severity. This dissertation assesses relative contributions of social experiences (low social support, discrimination, childhood trauma, and sexual objectification) to variation …

Spatiotemporal Interactions Between Deer And Cattle, Sydney Brewer

Honors Program: Senior Projects (Public)

Mule deer, white-tailed deer, and cattle are sympatric on the landscape throughout many portions of Nebraska and encounter each other in time and space. By considering variation in daily activity patterns and non-random patterns in the timing of passage through specific locations, we can better understand whether animals may be avoiding each other temporally when sharing space. I investigated temporal activity patterns and avoidance/attraction ratios to investigate if deer altered their activity patterns in the presence of cattle and if they exhibited avoidance at a study site near McCook, Nebraska, USA. We collected data from 19 game cameras that were …

Two-Dimensional & Three-Dimensional Microarray Cell Culture Using Elastomeric Assembly Substrates, Angel Olivera-Torres

Honors Program: Senior Projects (Public)

Tissue engineering and regenerative medicine represent the collection of all engineering disciplines brought together for the common goal of developing novel ways of growing tissues and organs in the laboratory. Efforts have made it possible to replicate or induce growth of 2D structures in the human body like skin, but the clinical need for on-demand solid organs has yet to be met due to lack of understanding of the variables responsible for organogenesis. Cell-colony heterogeneity, 3D-cellular architecture, bioactive molecules, and crosstalk communication between parenchymal cell populations need to be further investigated, and high-throughput technologies can rapidly increase the rate at …

The Relationship Between Time And Plant Diversity In Prairie Restorations Within The Prairie Corridor On Haines Branch, Elizabeth Park

Honors Program: Senior Projects (Public)

This study focuses on better understanding the relationship between the age of prairie restorations and their plant diversity. The study looks specifically at the prairie restorations within the Prairie Corridor on Haines Branch, located west of Lincoln, Nebraska. The data gathered from these restorations show a positive correlation between age and native plant diversity. This diversity indicates that the restorations are fulfilling their purpose by bringing native prairie plants back to the area. From the data I came to these four conclusions, 1) Because the study only included two restorations greater than 10 years old, it is unclear if the …

Integrating Indicators Of Natural Regeneration, Enrichment Planting, Above-Ground Carbonstock, Micro-Climate And Soil To Asses Vegetation Succession In Postmining Reclamation Intropical Forest, Trimanto Trimanto, Lia Hapsari, Sugeng Budiharta

Turkish Journal of Botany

Open-cast mining in tropical forests causes negative impacts on biodiversity and carbon storage. Postmining reclamation is therefore imposed to recover the vegetation despite the lack of understanding which indicators can be used to monitor the progress ofsuccession. This study proposes an integrated framework to assess the trajectory of vegetation succession in coal mining site in East Kalimantan, Borneo. We combine the indicators of floristic diversity of naturally growing terrestrial and epiphytic plants, survival and growth of enrichment planting of native plants, above-ground carbon stock of pioneer trees, and the measurements on micro-climate and soil conditions. We compare some indicators across …

Gc-Ms Profiling, Antioxidant, Antimicrobial Activities, Dna Cleavage Effect Ofsymphytum Aintabicum Hub.-Mor. & Wickens (Boraginaceae) And Its Anticancer Activityon Mcf-7 Cell Line, Alevcan Kaplan

Turkish Journal of Botany

Symphytum species, generally known as comfrey, have been used for ancient times in folk medicine for wounds, bone breakages, rheumatism, liver problems, and innumerable potentialities. However, many of the species belonging to the genus Symphytum have not been analyzed with scientific methods and principles yet. Therefore, this work is a guide for determining and researching the main gaps in the literature. In this study, MeOH and petroleum ether (PE) extracts of Symphytum aintabicum Hub.-Mor. & Wickens were analyzed for their biological activities and GC-MS analysis, antioxidant, antimicrobial activities, DNA cleavage effect, and anticancer activity on the MCF-7 human breast cell …

Screening Of Cytotoxicity And Dna Topoisomerase Iia Inhibitory Activity Of Turkish Onosma Species, Özge Güzel, Seda Duman, Si̇nem Yilmaz, Çi̇ğdem Karakoyun, Demet Kul, Ademi̇ Fahri̇ Pi̇rhan, Erdal Bedi̇r

Turkish Journal of Botany

Onosma L., the largest genus of Boraginaceae, is represented by 105 species in Turkey with an endemism rate of 52%. Phytochemical studies indicate that Boraginaceae plants mainly comprise naphthoquinones with a wide range of biological activities including anticancer, antiinflammatory, wound healing, and antioxidant effects. However, few taxa of the genus Onosma have been investigated in detail for their bioactivities. Considering the high rate of endemism and an inadequate number of bioactivity screening studies in literature, we aimed to evaluate the cytotoxic effects and topoisomerase inhibitory activities of some Onosma species growing in southwestern Turkey. Here, we describe a comprehensive cytotoxic …

Anticancer, And Antioxidant Activities Of Royal Jelly On Ht-29 Colon Cancer Cells Andmelissopalynological Analysis, Adnan Ayna, Abdullah Tunç, Seda Nur Özbolat, Aydin Şükrü Bengü, Gürkan Aykutoğlu, Deni̇z Canli, Ridvan Polat, Mehmet Çi̇ftci̇, Ekrem Darendeli̇oğlu

Turkish Journal of Botany

Royal jelly (RJ) is reflecting the flora around the apiaries as a result of the foraging activity of honeybees and therefore, pollen analysis could be used to verify its botanical/geographical origin. Colon cancer treatment by means of chemotherapeutics agents reflects a substantial problem for the organism due to high toxicity to other viable cells of the body. To explore a chemopreventive approach to enhancing colon cancer treatment efficacy, the antioxidant and antiproliferative effects of RJ in HT-29 colon cancer cells were assessed. Cell proliferation was performed by WST-1 assay, index of apoptosis was calculated by TUNEL Assay, antioxidant activities were …

Cover And Contents

Turkish Journal of Botany

No abstract provided.

Punk Pedagogy: Teaching To Confront Intersecting Discourses Of Domination, David Jagusch

Master's Theses and Doctoral Dissertations

Through the utilization of autoethnography and critical discourse analysis, this dissertation explores the applications of punk rock, its ethos and its philosophies, in the world of education. The overarching research questions driving the direction of this work are as follows: (a) What would an actualized punk pedagogy be characterized and defined as within the context of contemporary urban education in the United States? (b) How could such a pedagogy be applied in order to contest current inequalities and inequities that are the direct results of education being grounded in historical discourses of domination? and (c) How does punk relate to …

Southeast Michigan Wastewater Treatment Plants As Potential Sources Of Microplastic Pollution In The Rouge River And Huron River, Jennifer Troost

Master's Theses and Doctoral Dissertations

Plastic pollution is a global issue affecting the health and stability of freshwater and marine environments. Microplastics can be introduced into waterways from a variety of sources, such as agricultural runoff, anthropogenic litter, and wastewater treatment plants (WWTPs). To determine whether WWTPs are a source of microplastics to the Lower Rouge and Huron Rivers, we measured microplastic load upstream and downstream of two Southeast Michigan wastewater treatment plants: the Ann Arbor Wastewater Treatment Plant and Ypsilanti Community Utilities Authority (YCUA). Results from this study indicated that YCUA, which discharges into a small stream with limited watershed inputs, is a significant …

The Automated Administrative State: A Crisis Of Legitimacy, Ryan Calo, Danielle Keats Citron

Emory Law Journal

The legitimacy of the administrative state is premised on our faith in agency expertise. Despite their extra-constitutional structure, administrative agencies have been on firm footing for a long time in reverence to their critical role in governing a complex, evolving society. They are delegated enormous power because they respond expertly and nimbly to evolving conditions. In recent decades, state and federal agencies have embraced a novel mode of operation: automation. Agencies rely more and more on software and algorithms in carrying out their delegated responsibilities. The automated administrative state, however, is demonstrably riddled with concerns. Legal challenges regarding the denial …

Association Between Anthropometric Factors And Balance Among Elderly Fallers And Non-Fallers: A Cross-Sectional Study, Pothiraj Pitchai, Reshma Gurav, Srishti Kuldeep Chauhan

Internet Journal of Allied Health Sciences and Practice

Purpose: Falls are an emerging public health problem causing a cascade of medical, functional, and socio-economic consequences. Apart from other widely explored risk factors affecting balance, anthropometric factors are also known to have an impact on balance. However, this relationship hasn’t been studied extensively in older adults. This study aimed to evaluate the relationship between the anthropometric factors such as Body Mass Index (BMI), Body Fat Mass (BFM), Waist-Hip Ratio (WHR), Lower Limb Length (LLL), Foot Length (FL) and balance in the elderly among fallers and non-fallers. Method: This cross-sectional study was performed on 100 fallers and 100 non-fallers, aged …

Trauma-Informed Leadership, Corinne Brion

Educational Leadership Faculty Publications

According to recent data, over 34 million students have experienced at least one or more types of serious childhood trauma. As a result, current and prospective school leaders urgently need to develop trauma-driven skills and abilities in order to create safe schools for all students and raise academic outcomes. This teaching case study raises issues related to trauma experienced among students and its impact on students and school improvement. The author discusses one case in a fictitious district that is representative of the kind of traumas many other American schools face. I also provide additional resources for practitioners.

New Evidence For P-Gp-Mediated Export Of Amyloid-Β Peptides In Molecular, Blood-Brain Barrier And Neuronal Models, Amanda B. Chai, Anika M. S. Hartz, Xuexin Gao, Alryel Yang, Richard Callaghan, Ingrid C. Gelissen

Sanders-Brown Center on Aging Faculty Publications

Defective clearance mechanisms lead to the accumulation of amyloid-beta (Aβ) peptides in the Alzheimer’s brain. Though predominantly generated in neurons, little is known about how these hydrophobic, aggregation-prone, and tightly membrane-associated peptides exit into the extracellular space where they deposit and propagate neurotoxicity. The ability for P-glycoprotein (P-gp), an ATP-binding cassette (ABC) transporter, to export Aβ across the blood-brain barrier (BBB) has previously been reported. However, controversies surrounding the P-gp–Aβ interaction persist. Here, molecular data affirm that both Aβ₄₀ and Aβ₄₂ peptide isoforms directly interact with and are substrates of P-gp. This was reinforced ex vivo by the …

Corporate Misconduct In The Pharmaceutical Industry, Richard C. Ausness

Law Faculty Scholarly Articles

Sadly, many pharmaceutical companies have engaged in unethical or illegal behavior. The current opioid crisis is the most recent example of misconduct by pharmaceutical companies. Moreover, this pattern of conduct is neither rare, nor recent. Instead, it is long-standing and pervasive in nature. Furthermore, unlike wrongdoing by other businesses that cause primarily economic or environmental harm, wrongdoing by pharmaceutical companies, like that of asbestos or tobacco companies, may cause personal injuries and death on a large scale.

Question #1: Is There A Gender Gap In Performance On Multiple Choice Exams? A. Always B. Never C. Most Of The Time, Jane Bloom Grisé

Law Faculty Scholarly Articles

The correct answer to Question #1 is C. Most of the time, women score lower than men on multiple-choice exams. Question #2: How did you become interested in this topic?

A. The author likes to create multiple-choice tests.

B. The author does well on multiple-choice tests.

C. The author unexpectedly discovered this disparity.

The correct answer is C. I discovered this disparity unexpectedly and was surprised to find that women scored lower than men on multiple-choice exams and that multiple-choice exams underpredicted women's academic performance.

While educators might assume that different types of assessments such as multiple-choice and essays are …

Deodand, Brian L. Frye

Law Faculty Scholarly Articles

Law is a funny thing. Nobody really knows what it is. And there’s so much of it! If you started reading the United States Code out loud today, you’d be hoarse before you got to Title 17. Even still, you’d barely be getting started. The Library of Babel has nothing on the mountain of laws we’ve already got or the avalanche we keep creating. No one could possibly read them all, let alone remember what they say. What a conundrum!

And yet, as a practical matter, we still seem to have a pretty good idea of what the law expects …

Cartoon Contracts And The Proactive Visualization Of Law, Michael D. Murray

Law Faculty Scholarly Articles

Contracts have always relied on text first, foremost, and usually exclusively. Yet, this approach leaves many users of contracts in the dark as to the actual meaning of the transactional documents and instruments they enter into. The average contract routinely uses language that only lawyers, law-trained readers, and highly literate persons can truly understand.

There is a movement in the law in the United States and many other nations called the visualization of law movement that attempts to bridge these gaps in contractual communication by using highly visual instruments. In appropriate circumstances, even cartoons and comic book forms of sequential …

Plagiarism Pedagogy: Why Teaching Plagiarism Should Be A Fundamental Part Of Legal Education, Brian L. Frye, Megan E. Boyd

Law Faculty Scholarly Articles

As a practicing lawyer, if you aren’t plagiarizing, you’re committing malpractice. Litigators copy forms and arguments from winning briefs rather than bill their clients for reinventing the wheel. Transactional lawyers copy enforceable agreements to ensure their agreements are enforceable too. Partners routinely present documents prepared by associates (and sometimes even paralegals) as their own work. And judges are the most prolific plagiarists of all, copying briefs, opinions, treatises, and legal and nonlegal scholarship, adopting arguments from lawyers and holdings from other judges as their own and claiming authorship of opinions written primarily by their clerks or the parties to the …

The Effect Of Covid-19 On The Human Capital Management In Start-Ups In Egypt, Fayrouz El Dabbagh, Mariam Walid, Shorouk Fouda, Shahjahan Bhuiyan

Papers, Posters, and Presentations

Start-ups are institutionally fragile companies that deal with high degrees of risk and uncertainty, especially during short-term shocks, such as COVID-19. This policy brief attempts to identify the needed development in the start-up supporting ecosystem under COVID-19 pandemic, with a special focus on human capital management (HCM), decent work, and labor resilience in start-ups in Egypt. The core question of the paper is: How did COVID-19 pandemic affect the HCM practices in Egyptian start-ups and what is needed for start-ups in Egypt to recover from the crisis and sustain decent jobs and labor resilience?

Is Online Sport Betting Illegal In California?, James Fischer

UC Law Business Journal

No abstract provided.

Making And Breaking Kings: Generational Kingship And The Masculinities Of The Last Plantagenet Kings Of England,1308–1399, Richard Merrell

History Undergraduate Honors Theses

In this project, I apply ideas on hegemonic and chivalric masculinity to four generations of Plantagenet kings of England during the fourteenth century—Edward II, Edward III, Edward the Black Prince, Richard II. My aim is to decenter men from their default position at the normative gender. I specifically recontextualize kingship form the canonical frameworks of patriarchal power and privilege and reconfigure it in terms of new research on masculinity studies to understand how masculine identities interact with ideas on the generational component of kingship. This project has implications for other fields of study such as chivalry and medieval masculinity. I …

The Art Of Ethnography In Troubled Times, Paul Stoller

Anthropology & Sociology Faculty Publications

Many of our longstanding set of methods and denotative conventions of representation are no longer in harmony with the state of contemporary social, political, environmental and economic dysfunction. How can we create a representation that goes beyond the academic communication in a troubled world? How can we create "stories", which work as the glue that holds people together, in order to connect with them? This is the basic question in the Art of Ethnography, an idea that begins with Maurice Merleau-Ponty's, in his essay Eye and Mind. This piece suggests that the work of art is a pathway to an …

Origins Of The Unusual Stature Of The Susquehannock: Skeletal Remains From The Murray Garden Site (36br2), Marshall Joseph Becker

Anthropology & Sociology Faculty Publications

No abstract provided.

Communicating Crisis To Youth: The Role Of Caregiver Crisis Communication In Youth Sensemaking And Recovery., Ronda Oberlin Nowak

International Crisis and Risk Communication Conference

A qualitative study was conducted of the response to student deaths by the administrators of two rural high schools. The events are looked at in the dual context of incident management and communication processes, using Coordinated Management of Meaning (CMM) theory. Interviews were conducted with administrators and with members of a student support team that responded to these and similar events. The study finds that negotiation of meaning that takes place between students, and between students and caregivers, is key in students’ processing of the event that they are experiencing. It can also equip them to be more resilient to …

The Promotion Of Social Awakening Through The Speech Of Lewis Richardson: A Metaphorical Lens That Is Echoed Today, Suha Mohammed

International Crisis and Risk Communication Conference

This analysis will illustrate how a journey through the lens of metaphorical criticism can openly display the hardships, life, and reality of past African American voices, as their stories echo through the rhetor, Lewis Richardson. An examination of a striking speech that speaks volumes, recited by Lewis Richardson, will unravel the depth in imagery, interpretation, and symbolism from an application of a metaphorical critical lens that tells a story that just keeps getting louder and louder as it grows unheard. “When metaphor is seen as a way of knowing the world, it plays a particular role in argumentation” [8]. This …

Defining Plant Ecological Specialists And Generalists: Building A Framework For Identification And Classification, Alex N. Kirsch

All Graduate Theses, Dissertations, and Other Capstone Projects

This thesis is submitted in two chapters. The first chapter contains background research, literature review, relevant information, and justification for the primary study. The second chapter is written as a standalone paper for submission to Ecology and Evolution, that can be read and interpreted independently of the first chapter. Specialization is a widespread but highly ambiguous and context dependent ecological concept. Here, we construct a framework to assess specialization using an objective, metric-based approach, utilizing study system Quercus. To create Metric-Based Specialization rankings, metrics related to specialization were gathered for 141 Quercus species (Number of distinct inhabited ecoregions, extent of …

Applications Of The Match Model To Analyze Student Problem-Solving, Barbara Chiu

Honors Undergraduate Theses

Problem-solving has been recognized as a critical skill that students lack in the current education system, due to the use of algorithmic questions in tests that can be simply memorized and solved without conceptual understanding. Research on student problem-solving is needed to gain deeper insight into how students are approaching problems and where they lack proficiency so that instruction can help students gain a conceptual understanding of chemistry. The MAtCH (methods, analogies, theory, context, how) model was recently developed from expert explanations of their research and could be a valuable model to identify key components of student problem-solving. This project …