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2021

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The Gwangju Uprising In Films: Politics Of Memory And Narrative, Nontaporn Srisantisuk Jan 2021

The Gwangju Uprising In Films: Politics Of Memory And Narrative, Nontaporn Srisantisuk

Chulalongkorn University Theses and Dissertations (Chula ETD)

The Gwangju Uprising is one of the remarkable democratic movements in the contemporary South Korean society as it depicted the brutality of the military government. Thus, the incident had influenced the later democratic movement. Though more than 40 years had passed, the memory of the incident still made it present in Korean society. The narrative of the incident had been repeatedly told not only to commemorate the sacrificial of the people but it was also a part of memory politics of remembering and forgetting. The memory of the uprising was depicted through several medias including films to integrate its own …

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Development Of Mucoadhesive Polymeric Nanoparticles For Intranasal Delivery Of Favipiravir In Treating Sars-Cov-2 Infection, Khent Alcantara Jan 2021

Development Of Mucoadhesive Polymeric Nanoparticles For Intranasal Delivery Of Favipiravir In Treating Sars-Cov-2 Infection, Khent Alcantara

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nanoparticles (NPs) have been used as an effective carrier for transmucosal delivery of drugs through their prolonged residence time and deposition, or the enhanced permeation through the mucosa. In this study, we aimed to design a nanocarrier using the combined mucoadhesive (M) properties of chitosan (CS) and alginate (ALG) polymers for the intranasal delivery of favipiravir (FVR) in treating SARS-CoV-2 infection. The optimized FVR-loaded mucoadhesive CS-coated ALG-NPs (FVR-MCS-ALG-NPs) rendered suitable size (233.5 nm), zeta potential (-21.6 mV), loading capacity (26.0%), and encapsulation efficiency (84.6%) for transmucosal delivery. Superior mucoadhesiveness and higher permeation and deposition in the porcine nasal mucosa of …

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Development Of Elisa For Detecting Antibody Against Bartonella Spp. Specific Protein In Cats And Its Application In Natural Infection, Krissda Boonaramrueng Jan 2021

Development Of Elisa For Detecting Antibody Against Bartonella Spp. Specific Protein In Cats And Its Application In Natural Infection, Krissda Boonaramrueng

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aims to evaluate the risk factor and an association between Bartonella spp. infection and immune status by using retroviral-infected cats as an immunocompromised model and to develop the recombinant B. henselae specific antigen protein (17kDa and GroEL)-based ELISA test for antibody detection against Bartonella spp. infection in cats. From 2017 to 2020, 161 client-owned clinical healthy cats at veterinary clinics and hospitals in the Bangkok metropolitan area were recruited and tested for Bartonella spp. infection statuses (PCR and IFA serology), blood profiles, feline retroviral statuses (FIV and FeLV), and T lymphocyte subsets (CD4+, CD8+, and CD4+ to CD8+ …

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Influences Of Herbicides On Health Of Rice Frog Fejervarya Limnocharis Populations In Nan Province, Thailand, Luhur Septiadi Jan 2021

Influences Of Herbicides On Health Of Rice Frog Fejervarya Limnocharis Populations In Nan Province, Thailand, Luhur Septiadi

Chulalongkorn University Theses and Dissertations (Chula ETD)

Intensive and continuous herbicide use in agriculture may pose a risk to health of environment and non-target organisms, including amphibian. Prior research conducted between 2010-2011 using the rice frog, Fejervarya limnocharis, as a sentinel revealed an accumulation of herbicides (atrazine, glyphosate, and paraquat) in environmental samples and frog tissue, as well as adverse effects on the health status. This study aims to determine the potential influence of herbicides on population health of the rice frog. Between July 2020 and February 2021, frogs were collected from two paddy fields with varying degrees of herbicide use in Nan province, Thailand. The results …

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"Necessary But Not Sufficient": Chancery Court Clarifies Role Of Enhanced Scrutiny In Assessing Damages Claims Against Corporate Actors In Revlon Transactions, Robert S. Reder, Connor J. Breed Jan 2021

"Necessary But Not Sufficient": Chancery Court Clarifies Role Of Enhanced Scrutiny In Assessing Damages Claims Against Corporate Actors In Revlon Transactions, Robert S. Reder, Connor J. Breed

Vanderbilt Law Review En Banc

No abstract provided.

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The Role Of Environmental Temperature In Immunocompetence And Disease Susceptibility In Bivalves, George Mason Jan 2021

The Role Of Environmental Temperature In Immunocompetence And Disease Susceptibility In Bivalves, George Mason

School of Biological and Marine Sciences Theses

Disease outbreaks and mass mortality events affecting marine species and ecosystems during periods of high temperature have increased in frequency and intensity over the past several decades. Accordingly, understanding the causes of such thermally-induced outbreaks is increasingly important, particularly in the context of global climate change and predictions of increased pathogen prevalence and disease incidence. Whilst our understanding of immune functions and their adequate energetic provisioning for disease resistance is well developed, little is known on how temperature affects immunological and energetic status in bivalves. Furthermore, even less is known on the potential combined effects between thermal and pathogenic stressors …

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Do Abiotic Environmental Drivers Disrupt The Biotic Response Of Marine Larvae?, Stanley Butt Jan 2021

Do Abiotic Environmental Drivers Disrupt The Biotic Response Of Marine Larvae?, Stanley Butt

School of Biological and Marine Sciences Theses

Phenotypic plasticity, the ability of a given genotype to express different phenotypes in response to altered environmental conditions has been identified as a means by which organisms may be able to cope with environmental change. While significant progress has been made in the study of phenotypic plasticity in response to both individual and combined abiotic environmental drivers, very few studies have investigated the effects of abiotic and biotic drivers in combination. In this thesis, I investigate the combined effects of increased temperature (15 °C versus 20 °C) and the presence of predation threat in the form of predatory kairomones (skin …

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Dirofilaria Immitis Prevalence In Canis Latrans In Kentucky, Melanie Ann Brandon Jan 2021

Dirofilaria Immitis Prevalence In Canis Latrans In Kentucky, Melanie Ann Brandon

Murray State Theses and Dissertations

Dirofilaria immitis (canine heartworm) was found in forty-two (42) of the two hundred seventy-five (275) Canis latrans (coyote) necropsied in the state of Kentucky from November 27, 2019 through March 3, 2021. Thirty-five (35) of the positive cases were from western Kentucky region with the other seven spread across the state. With this group of coyotes, one hundred fifty-eight (158) were male and the other one hundred six-teen (116) were female. The estimated age ranged from a pup to senior dogs. A little over forty percent of the dogs were obtained through coyote/predator tournaments; the remaining were acquired from pest …

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Monitoring Relationships Between Corticosterone And Snake Fungal Disease In Timber Rattlesnakes (Crotalus Horridus) In Western Kentucky, John Bromley Hewlett Jan 2021

Monitoring Relationships Between Corticosterone And Snake Fungal Disease In Timber Rattlesnakes (Crotalus Horridus) In Western Kentucky, John Bromley Hewlett

Murray State Theses and Dissertations

Over the past four decades, emergent fungal diseases have been the most devastating relative to species declines and extinctions. While most research has focused on fungal diseases affecting amphibians and bats, less has focused on diseases like snake fungal disease (SFD), caused by Ophidiomyces ophiodiicola (Oo). SFD was first described in 2006 in North America within a Timber rattlesnake (Crotalus horridus) population in New Hampshire. Since then SFD has been documented in 19 US states, one US territory (Puerto Rico), and Europe. SFD causes high mortality in some species, including the Eastern Massasauga rattlesnakes (Sistrurus …

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Males Of The Wolf Spider Rabidosa Rabida Use Two Mechanisms To Stun Females During Copulation, Daniel Schoenberg Jan 2021

Males Of The Wolf Spider Rabidosa Rabida Use Two Mechanisms To Stun Females During Copulation, Daniel Schoenberg

Murray State Theses and Dissertations

The differences in energetic input between the sexes required to produce gametes translates to the differences in reproductive behavior and overall mating systems seen in a species. Females generally produce a few energetically and resource expensive eggs and typically choose a high-quality suitor to ensure she has high quality offspring. In contrast, males produce abundant energetically cheap sperm and attempt to fertilize as many eggs as possible in as many females as possible. Both sexes are trying to maximize their inclusive fitness, but the dichotomy of interests can lead to sexual conflict and perhaps extreme or unusual behaviors such as …

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Characterizing The Host Usage And Development Of Ormia Lineifrons (Diptera: Tachinidae), Kyler J. Rogers Jan 2021

Characterizing The Host Usage And Development Of Ormia Lineifrons (Diptera: Tachinidae), Kyler J. Rogers

Murray State Theses and Dissertations

Insect communication systems are strongly driven by the evolution of signals or signal preferences. These systems rely on a signaler to truthfully emit signals for receivers to interpret. Often, these signals are conspicuously broadcasted. Conspicuous signals involved in animal communication are intended to attract mates, however, these signals are often exploited by eavesdroppers. Thus, many communication systems experience natural selection and sexual selection acting in opposite directions. New adaptations can arise in response to selective pressures, such as eavesdroppers, leading to co-evolving systems between eavesdroppers and hosts, for example. Understanding these systems can provide valuable insight into how unintended receivers …

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An Investigation Into Cte Classroom Instructional Strategies, Jonathan Walker Jan 2021

An Investigation Into Cte Classroom Instructional Strategies, Jonathan Walker

Murray State Theses and Dissertations

This researcher conducted this ex post facto study with the help of career and technical education (CTE) teachers across the country. The research was a survey of classroom instructional strategy usage, a teacher’s familial impact on classroom instruction strategies used, and the effects of Covid-19 on classroom strategies used. Data suggested that CTE teachers use different instructional strategies based on teacher demographics and that Covid-19 did have an effect on CTE teachers’ use of instructional strategies. This data suggested the five most used classroom instructional strategies were questioning, guided practice, demonstrations, lab activities, and whole group discussion.

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Hadiya, Hinduism And Heterosexuality, Madhavi Menon Jan 2021

Hadiya, Hinduism And Heterosexuality, Madhavi Menon

Socio-Legal Review

Depending on one’s point of view, the Hadiya case caught the national imagination for being a shocking example of “love jihad” or a horrifying instance of the growing criminalisation of desire. Since the latter view is informed by the former, this essay looks at the ways in which the nexus of patriarchy, nationalism, and sexual phobia has built up in India over the centuries, beginning with the laws promulgated under British rule. The emphasis on “personal laws” separable by religious community, the very creation of a religious community as a singular entity, the inexorable march towards a religiously-inflected nationalism, have …

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Hydrogeochemical Fingerprints Of A Mixohaline Wetland In The Mediterranean: Güllük Coastal Wetland Systems- Gcws (Muğla, Turkey), Adi̇le Meli̇s Somay Altaş Jan 2021

Hydrogeochemical Fingerprints Of A Mixohaline Wetland In The Mediterranean: Güllük Coastal Wetland Systems- Gcws (Muğla, Turkey), Adi̇le Meli̇s Somay Altaş

Turkish Journal of Earth Sciences

The Güllük coastal wetland system (GCWS), which is located at the contact point of the Menderes Massif and Lycian Nappe, consists of both brackish karstic [Güllük Lagoon wetland (GLW)] and saline [Boğaziçi-Tuzla (Bargylia) coastal wetland (BTW)] ecosystems in western Turkey, and is under protection as a national wetland of importance. This area is important for its unique wetland features, aquaculture, tourism, agriculture, Bodrum airport, and Güllük port facilities. The aim of this study was to evaluate the GLW and BTW, both hydrogeologically and hydrogeochemically, for the first time together. The mixohaline GCWS is recharged from precipitation, streams, and brackish karstic …

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The Multidisciplinary Approaches On Facies Developments And Depositional Systems Of The Bahçecik Travertines, Gümüşhane, Ne-Turkey, Rai̇f Kandemi̇r, Ezher Tagli̇asacchi̇, Mi̇ne Sezgül Kayseri̇ Özer, Di̇lek Şaffak, Fati̇h Köroğlu, Hsun-Ming Hu, Chuan-Chou Shen Jan 2021

The Multidisciplinary Approaches On Facies Developments And Depositional Systems Of The Bahçecik Travertines, Gümüşhane, Ne-Turkey, Rai̇f Kandemi̇r, Ezher Tagli̇asacchi̇, Mi̇ne Sezgül Kayseri̇ Özer, Di̇lek Şaffak, Fati̇h Köroğlu, Hsun-Ming Hu, Chuan-Chou Shen

Turkish Journal of Earth Sciences

The Bahçecik travertines, located in Gümüşhane (NE-Turkey) have been investigated for the first time using a multidisciplinary approach, which included sedimentological (lithofacies, depositional system), petrographic, radiometric 230Th dating, geochemical analysis (stable isotopes), palynomorphs and geophysics (GPR). A carbonate build-up, 12 m thick, was formed with some interruptions, through the middle Pleistocene period. For this study, two travertine sections (F and D) were extensively used to figure out palaeoenvironmental and palaeoclimatic proxies. The main precipitation cycles, separated by palaeosol levels, have been described and interpreted from a sedimentological perspective. The carbonate deposits consist of shrubs, crystalline crust, reed, laminated (micritic), pisoids, …

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Management And Dietary Strategies To Mitigate Environmental Stressors In Northern Plains Cattle Feeding Systems, Warren Carl Rusche Jan 2021

Management And Dietary Strategies To Mitigate Environmental Stressors In Northern Plains Cattle Feeding Systems, Warren Carl Rusche

Electronic Theses and Dissertations

Three studies were undertaken to examine strategies to mitigate environmental stress faced by Northern Plains cattle feeders. In the first study, 46 feedlot managers from SD (n = 21), MN (n = 6), and NE (n = 19) were surveyed on use and perceptions of heat stress (HS) mitigation strategies. All respondents avoided cattle handling during heat stress events and incorporated some method of HS mitigation. Buildings or shades were perceived as the most successful strategy (60.9%) and were most commonly named as strategies managers would like to employ (63% for shades and 17.4% for buildings). Increasing dietary corn silage …

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Identification Of Loci Influencing Teosinte Crossing Barrier 1 (Tcb1) Efficacy In Maize By Quantitative Trait Loci (Qtl) Mapping And Genome-Wide Association Study (Gwas), Namrata Maharjan Jan 2021

Identification Of Loci Influencing Teosinte Crossing Barrier 1 (Tcb1) Efficacy In Maize By Quantitative Trait Loci (Qtl) Mapping And Genome-Wide Association Study (Gwas), Namrata Maharjan

Electronic Theses and Dissertations

Pollen cross-contamination has been a major problem for maize breeders. Various mechanical methods applied to avoid the contaminations are ineffective. The genetic factors related to maize fertilization can be used to develop an effective method to prevent pollen contamination. Pollen rejection ability controlled by Teosinte crossing barrier 1 (Tcb1) is such a genetic system. Silks possessing dominant Tcb1-s reject pollen possessing the recessive allele (tcb1). Successful fertilization occurs when Tcb1-s pollen falls upon tcb1 silks. The efficacy of dominant Tcb1-s was, however, reduced when repeatedly backcross with maize inbred lines, which suggests that there are modifiers to Tcb1-s. To find …

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Pollinator Ecology In Agroecosystems Of Eastern South Dakota, Isabela Beatriz Vilella-Arnizaut Jan 2021

Pollinator Ecology In Agroecosystems Of Eastern South Dakota, Isabela Beatriz Vilella-Arnizaut

Electronic Theses and Dissertations

Community structure contributes to ecosystem persistence and stability. To understand the mechanisms underlying pollination and community stability of natural areas in a human influenced landscape, a better understanding of the interaction patterns between plants and pollinators in disturbed landscapes is needed. Furthermore, understanding the potential conservation value in green spaces such as botanical gardens could assist in preserving and bolstering plant-pollinator interactions. Our study takes place in the Northern Great Plains which still retains extensive tracts of remnant temperate grassland habitat within a matrix of varying land-uses. First, we used a network-based approach to quantify how temperate grassland attributes and …

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Therapeutic Immunoglobulin G Surface Mobility Promotes Antibody-Dependent Cellular Phagocytosis By Arp2/3 And Syk Mediated Rearrangement Of Fcγ Receptors, Seongwan Jo Jan 2021

Therapeutic Immunoglobulin G Surface Mobility Promotes Antibody-Dependent Cellular Phagocytosis By Arp2/3 And Syk Mediated Rearrangement Of Fcγ Receptors, Seongwan Jo

Electronic Theses and Dissertations

Therapeutic antibodies are rapidly growing class of drugs for treating cancers and immunological disorders by targeting specific antigens or blocking certain pathway to inhibit the tumor growth. In cancer immunotherapy, it was found that Fcγ receptor (FcγR) in immune cells play an important role in antibody dependent cell toxicity against tumor cells. Therefore, understanding FcγR activation mechanism, which requires ligation with immunoglobulin (IgG), is crucial to enhance potency of therapeutic antibodies. One crucial immune responses triggered upon FcγR ligation with IgG is phagocytosis which indicates clearing targets by engulfment. It is known that FcγRs form microclusters which gets rearranged during …

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Assessing Dairy Farm Employees Health, Leyby Stephany Guifarro Rodriguez Jan 2021

Assessing Dairy Farm Employees Health, Leyby Stephany Guifarro Rodriguez

Electronic Theses and Dissertations

This Master thesis evaluates the impact of general health care and eating habits (Study 1), vision care (Study 2), and mental health status (Study 3) on Latino dairy farmworkers lifestyle and work performance in South Dakota. We hypothesized that the health status of dairy workers has a negative impact on the workers’ job performance. In study 1, data from a total of 70 participants were collected, using a face-to-face survey in Spanish, which allowed us to assess various topics and details related to employees’ daily routine tasks, eating habits, and general health status. Furthermore, recommendations to improve general health care …

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Milk Phospholipids Extraction Using Switchable Solvents, Kaavya Rathnakumar Jan 2021

Milk Phospholipids Extraction Using Switchable Solvents, Kaavya Rathnakumar

Electronic Theses and Dissertations

Phospholipids (PLs) found in milk are of great interest due to their health and nutritional benefits associated with their consumption. By-products generated during the manufacture of dairy products represent a source of PLs with potential for value-added opportunities. Currently, the extraction of PLs from by-products results in overall lowefficiencies, and it involves subsequent solvent separation and lipid recovery. This dissertation studied the extraction of milk PLs from by-product streams with a tertiary anime (N, N-dimethyl cyclohexylamine, CyNMe2) as a switchable hydrophilicity solvent. This type of solvents can be reversibly switched between a hydrophobic and hydrophilic form in the presence or …

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College Students Conceptions Of Particulate Nature Of Matter And The Impact On Research Instrumentation, Bridget Klutse Jan 2021

College Students Conceptions Of Particulate Nature Of Matter And The Impact On Research Instrumentation, Bridget Klutse

Electronic Theses and Dissertations

The main objective of this research was to explore the understanding and conceptions of Particulate Nature of Matter (PNM) with Chem 115 L students as the participants. Conceptions were defined specifically as beliefs and alternative beliefs about topics. The research also assessed the impact of analytical instrumentation in the chemistry laboratory on learning chemistry concepts. Eight questions (8) with multiple choice answers were administered to 10 students at the beginning and after the Fall 2018 semester via selective/purposeful sampling. Data were collected using surveys (pre- and post-surveys) and interviews (pre- and postinterviews), then analyzed quantitatively and qualitatively. The eight questions …

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Implications Of Broadleaf, Grass, And A Blend Of Broadleaf And Grass Cover Crops On Soil Health And Corn Production In South Dakota, Hunter Bielenberg Jan 2021

Implications Of Broadleaf, Grass, And A Blend Of Broadleaf And Grass Cover Crops On Soil Health And Corn Production In South Dakota, Hunter Bielenberg

Electronic Theses and Dissertations

Cover crops have recently gained attention in the U.S. Midwest because of their potential to increase soil organic matter and protect overall soil health. This study was conducted to determine the effects of different cover crop mixtures on soil health measurements and corn grain yield at increasing nitrogen (N) rates. Cover crops were planted in the fall after small grains harvest as a dominantly grass mixture, dominantly broadleaf mixture, or a 50/50 grass and broadleaf mixture with a no cover crop control. Soil and cover crop biomass samples were collected in the fall before winter cold termination and in the …

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Soil Organic Carbon, Hydro-Physical Properties, Pore Structure And Greenhouse Gas Fluxes Under Integrated Crop-Livestock System, Jashanjeet Kaur Dhaliwal Jan 2021

Soil Organic Carbon, Hydro-Physical Properties, Pore Structure And Greenhouse Gas Fluxes Under Integrated Crop-Livestock System, Jashanjeet Kaur Dhaliwal

Electronic Theses and Dissertations

Integrated crop-livestock system (ICLS) can improve soil organic carbon (SOC), enhance soil hydro-physical properties, and mitigate greenhouse gas (GHG) emissions. The objectives of this study were to: (i) investigate the influence of grazing, cover crop (CC), and a combination of grazing and CC on labile soil carbon (C) and nitrogen (N) fractions and soil enzyme activity, (ii) assess the impacts of short-term (3-4 years) and long-term (>30 years) ICLS on SOC, bulk density, structural quality and water infiltration, (iii) evaluate soil pore structural properties such as porosity, number of pores, pore size, pore shape, fractal dimension, anisotropy and tortuosity …

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Impact Of Carcass Chilling System On Carcass Characteristics And Biochemical Changes In Beef Carcasses, Lydia Margaret Hite Jan 2021

Impact Of Carcass Chilling System On Carcass Characteristics And Biochemical Changes In Beef Carcasses, Lydia Margaret Hite

Electronic Theses and Dissertations

Effective and efficient chilling of beef carcasses will directly influence meat quality and consumer acceptance. Over the past century the United States’ meat industry has evolved, and spray chilling system have become common practice utilized by the beef industry. However, many of the chilling systems presently in use were designed to chill carcasses averaging lighter than the average beef hot carcass weight of today. Beef hot carcass weight has increased 68 kilograms from 1991 to 2019. The increase in beef hot carcass weight could result in longer chilling periods and present possible challenges for chilling systems used by the beef …

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The Influence Of Carcass Weight On Beef Primal Temperature, Tenderness, And Palatability, Samantha Egolf Jan 2021

The Influence Of Carcass Weight On Beef Primal Temperature, Tenderness, And Palatability, Samantha Egolf

Electronic Theses and Dissertations

The United States beef industry has experienced increasing hot carcass weights (HCW) and improvements to quality grade the last three decades. Postmortem chilling of beef carcasses is critical to overall product quality. Carcass weight and composition may influence carcass temperatures during postmortem chilling. The objective of this research was to evaluate the effects of HCW and quality grade during postmortem chilling and on product quality. A-maturity carcasses were selected by weight [light = 296–341 kg; middle = 386–432 kg; heavy = 466–523 kg]. A 20 cm data logger was placed into the chuck and round and a 10 cm data …

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Exploration Of Host Health Benefits By A Defined Consortium Of Butyrate-Producing Human Gut Bacteria In Gnotobiotic Mouse Model, Linto Antony Jan 2021

Exploration Of Host Health Benefits By A Defined Consortium Of Butyrate-Producing Human Gut Bacteria In Gnotobiotic Mouse Model, Linto Antony

Electronic Theses and Dissertations

Aberrant gut microbiota composition is found to be associated with several human diseases such as inflammatory bowel diseases (IBD). Reduction in butyrate producing bacteria is one of the characteristic features of such dysbiotic bacterial community in the gut. Modulation of gut microbiota to bring the dysbiotic state back to normal healthy state is a promising therapeutic strategy to cure several diseases like recurrent Clostridium difficile infection (rCDI) and IBD where traditional therapies using pharmacological substances fails to make a difference. Restoration of butyrate producers is found to be an effective method of such gut microbiota modulation. The potential to produce …

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Gene Network And Pathway Analysis Of Transcriptional Signatures Characterizing Sole Ulcer And Digital Dermatitis In Dairy Cows, Roshin Anie Mohan Jan 2021

Gene Network And Pathway Analysis Of Transcriptional Signatures Characterizing Sole Ulcer And Digital Dermatitis In Dairy Cows, Roshin Anie Mohan

Electronic Theses and Dissertations

This study aimed to evaluate the transcriptomic profile of both corium tissue from lactating dairy cows experiencing sole ulcers and skin lesions from lactating dairy cows diagnosed with digital dermatitis (DD). Hoof biopsies were performed in multiparous Holstein dairy cows selected based on their condition as clinically healthy or diagnosed with sole ulcers (n=7/group). Similarly, skin biopsies were taken from the center of active (M2/M4.1) DD lesions or non-active (M0/M4/M1) from multiparous Holstein dairy cows (n = 7/group) to assess the impact of DD on the skin transcriptome via RNA-seq analysis. All RNA samples were sequenced using Illumina, NovaSeq S4 …

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Design, Synthesis, And Evaluation Of Glutathione Derivatives As Brain Targeting Agents, Yue Huang Jan 2021

Design, Synthesis, And Evaluation Of Glutathione Derivatives As Brain Targeting Agents, Yue Huang

Electronic Theses and Dissertations

Treatment of central nervous system (CNS) diseases, such as Alzheimer’s disease, Parkinson’s diseases, and brain tumors, is still a challenge due to the existence of the blood-brain barrier (BBB). The BBB as a membrane barrier that separates systemic blood circulation from the CNS is structurally formed by endothelial cells, astrocyte, pericyte and neurons and is one of the crucial protection mechanisms for the CNS. The BBB protects the brain by preventing foreign compounds (non-endogenous compounds) from entering the brain and helps maintain brain homeostasis. In addition, the presence of drug efflux pumps (i.e., P-glycoproteins, multidrug-resistance proteins) in the BBB helps …

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Evaluating Impacts Of Tryptophan And Branched Chain Amino Acids In Swine Diets Containing Corn Based Dried Distillers Grains On The Growth Performance And Carcass Characteristics Of Grow-Finish Pigs, David Alan Clizer Jan 2021

Evaluating Impacts Of Tryptophan And Branched Chain Amino Acids In Swine Diets Containing Corn Based Dried Distillers Grains On The Growth Performance And Carcass Characteristics Of Grow-Finish Pigs, David Alan Clizer

Electronic Theses and Dissertations

A total of four studies were conducted in an effort to determine the impact of Trp and the BCAA in swine diets containing DDGS or HPDDG on the growth performance and carcass characteristics of the growing and finishing pig. The first study utilized 1,170 pigs (PIC 800 x PIC, initial BW 38.6 kg) in a 98-d grow-finish study to determine the performance response of pigs fed increasing levels of SID Trp:Lys in swine diets containing 40% DDGS. Treatments consisted of diets containing 40% DDGS with a SID Trp:Lys ratios of 15, 18, 21, or 24% or a corn-SBM diet for …

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