Digital Commons Network^™

Deciphering Transcriptomic Changes In Chemobrain: A Comprehensive Review, Tusar Kanta Acharya, Yuan Pan, Peter M Grace, Cobi J Heijnen, Rajasekaran Mahalingam

Faculty, Staff and Student Publications

Chemotherapy-induced cognitive impairments (CICI), colloquially known as "chemobrain," represents a profound and debilitating side effect experienced by a significant number of cancer survivors, impacting their memory, multitasking, and quality of life. This review critically evaluates the molecular mechanisms underlying CICI, with a particular focus on the insights gained from transcriptomic analyses. As cancer incidence rises globally, understanding the complex interplay between chemotherapy agents and their cognitive repercussions becomes increasingly vital. Key mechanisms implicated in CICI include blood-brain barrier disruption, neuroinflammation, and oxidative stress as a result of various chemotherapy treatments, such as doxorubicin, cisplatin, and paclitaxel. We delve into advanced …

Umi Matsuzaki’S Representation Of War Trauma: A Semiotic Approach To Studio Ghibli’S From Up On Poppy Hill, Wedhowerti Wedhowerti

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

Japanese films that explore war trauma are relatively rare, and this research departs from that gap by analyzing Studio Ghibli’s From Up on Poppy Hill. The film reflects the conscience of Japanese society by depicting the realities of post-war life in the 1960s. Using a qualitative descriptive approach, this study examines how the main character, Umi Matsuzaki, represents war trauma through eight selected scenes and how such trauma encodes myth. By applying Roland Barthes’ semiotic theory, the findings reveal that Umi embodies symptoms of post-traumatic stress disorder (PTSD), manifested primarily through avoidance and intrusion. Her trauma is deeply rooted …

“Earth Care, Babes 💚”: Environmental Sustainability In Instagram Travel Narratives, Wawan Eko Yulianto, F.X. Dono Sunardi, Alodia Clea Amanda, Irene Theofine, Pricillia Tamara Damaris

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

Throughout history, travel narratives have taken up various forms and served various purposes. The changes of forms and functions were influenced by the spirit of the age. Today, in the contemporary digital era, social media platforms like Instagram have transformed travel narratives into stories combining images and texts that significantly impact public attitude on travel and tourism. On certain occasions, Instagram travel narratives contribute to the dangerous trend of mass tourism, although there are moments when the same travel writing form advocates sustainability. This study investigates the extent to which travel narratives by prominent Indonesian travel influencers on Instagram advocate …

Visual Narrative Through The Wimba Approach In Tahilalats Comic With Campaign Theme Bersama Stop Judi Online, Rangga Pangkuluhur Gumelar, Basnendar Herry Prilosadoso

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

Comics, as a medium for conveying ideas and concepts through imagery, integrate textual and visual elements to construct meaning and communicate messages effectively. Their distinctive visual communication enables the delivery of complex social issues in an accessible manner through characters, panels, layouts, and visual representations of sound and dialogue. This study analyzes the Tahilalats comic (2024 edition), which incorporates the hashtag #bersamastopjudol as part of a visual campaign against online gambling addiction. The narrative is presented entirely through images without verbal language. The research applies Primadi Tabrani’s Wimba theory to decode visual language and Roland Barthes’ semiotics to interpret symbolic …

Art Management Of Batavia Madrigal Singer (Bms) In The International Choir Competition, Agustinus Arbi Putra, Hery Budiawan, Rien Safrina

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

This study aims to find out the management of the Batavia Madrigal Singers (BMS) choir, especially in achieving achievements at the international level. Batavia Madrigal Singers is a choir from Indonesia that is consistent in participating in and winning choir competitions at the international level. This study uses a qualitative research method with a descriptive approach through observation techniques, interviews, and literature studies. The results of the study show that the art management of Batavia Madrigal Singers includes (1) Planning, (2) Organization, (3) Leadership, and (4) Control. Based on the results of the research, it was found that Batavia Madrigal …

"The Biggest Outing Of The Year": Hops, Harvest, And The Making Of Oregon's Largest Annual Gathering, 1880-1930, Asher Bernick-Roehr

University Honors Theses

When the end of August came around, all kinds of people started rolling into the little town of Independence, Oregon. Some walked, some came by train, others by wagon, and still others by ferry, motorboat, and canoe. There were Armenians, Swedes, Chinese, Japanese, Indians, Russians, Germans, and Indigenous peoples. There were those who were called fruit tramps, individuals and families who managed to bridge the vast distances across the West to harvest whichever crop needed hands. Entire families arrived, young and old, healthy and sick, with horses, mules, chickens and dogs in tow. Rich men came dressed as poor men …

Water Pollution In Yogyakarta 1926–1942, Nur Aini Setiawati, Edy Supratno, Santi Muji Utami, Krisnanda Theo Primaditya

Paradigma: Jurnal Kajian Budaya

Water pollution in Yogyakarta has a long history dating back to the colonial era in 1926. Therefore, the main issue addressed in this writing is why water pollution occurred in Yogyakarta from 1926 to 1942. Basically, there are two factors influencing water pollution, namely natural factors and human factors. Using a historical research method, this study aims to examine water pollution in the Yogyakarta region, so that the government and the community can seek solutions. The sources used include collections from Algemeen Handelsblad voor Nederlandsch-Indie, De Locomotief, De Nieuwe Vorstenlanden, De Preanger Bode, and contemporary newspapers. The research findings …

From Anxiety To Action: Understanding Financial Worries And Strategies To Boost Insurance Take-Up, Hui Shan Lee, Kee Seng Kuang

International Journal of Management, Finance and Accounting

In developing countries, inadequate insurance and financial planning have led experts to call for government intervention to avoid potential financial crises. In Malaysia, where increasing insurance uptake is a national priority, this study examines how education and socioeconomic factors influence financial concerns. Using a regression model, this study analyses data from 1,000 survey responses from Malaysia in the Global Findex database, examining the effects of education, income, gender, age, and urbanicity on various financial worries, including retirement, medical expenses, monthly bills, and education costs. Findings show that higher education levels are associated with reduced financial anxiety around medical expenses and …

The Research University, Industry And Artificial Intelligence, Hamlet Isakhanli

Khazar Journal of Humanities and Social Sciences

Scientific research in cooperation between science and industry occurs mainly in research universities. This article begins with a brief history of research universities, a discussion of their nature and form. Their evolution and development in Europe, the USA and China are recalled; the special importance of Graduate Schools is underlined. Cooperation between the worlds of university and industry is studied using the example in the USA of Silicon Valley, a world leader in its field and initiated by Stanford University. Presented alongside the positive American experience, is the rather negative experience of the ``Russian syndrome''. The development of semiconductor, transistor …

Effect Of Garcinol Against Arsenic-Induced Neurobehavioral Alterations And Liver And Kidney Dysfunction In Albino Mice, Abdulmohsen I. Algefare

BioMedicine

The extended exposure to inorganic arsenic is commonly linked to brain damage through oxidative and apoptotic processes. The compound known as Garcinol (GCL) has garnered significant interest due to its potential advantages for human well-being. Nevertheless, the ability of GCL to protect against toxicity generated by arsenic in the brain has not yet been investigated. Hence, our study aimed to examine the neuroprotective effectiveness of GCL in mitigating the detrimental impacts of sodium arsenite (SA) on behavioral patterns, the molecular mechanisms, apoptotic markers, and oxidative stress parameters in the brain, liver, and kidney of mice. The mice were categorized into …

An Investigation Into The Potent Anticancer, Antimicrobial, And Anti-Inflammatory Activities Of A Punica Granatum Nanoemulgel, Ahmad M Eid, Murad Abualhasan, Yara Khaliliya, Zeina Sinan, Aya Khaliliya

BioMedicine

Purpose: The objective of this study is to formulate a nanoemulgel using Punica granatum (P. granatum) seed oil and study the antibacterial, anticancer, and anti-inflammatory properties. Methods: The process to formulate a nanoemulsion from P. granatum seed oil involved using the self-nanoemulsifying technique, with Span 80 and Tween 80 serving as the emulsifying agents. Carbopol hydrogel was combined with the nanoemulsion to produce the nanoemulgel. The particle size, polydispersity index (PDI), rheological behavior, antibacterial, cytotoxic, and anti-inflammatory properties were subsequently examined.

Results: The nanoemulsion formulation with a PDI of 0.229 and a particle size of 189.44 nm was …

Gc-Ms Analysis Of Bioactive Constituents From The Leaves Of Portulaca Afra Jacq. And Portulaca Grandiflora Hook, Sadeq S.K.Al-Taie, Noor F.M. Al-Kenane, Zaidon T. Al-Aqbi

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Portulaca afra and Portulaca grandiflora are traditional medicinal that grow as ornamental plants in Iraq. The present study was conducted for GC-MS analysis of the leaves of these plants to identify possible bioactive compounds. Seventy-nine compounds were recorded in the methanolic extract in Portulaca afra and ninety-two in Portulaca grandiflora. A literature survey revealed that some compounds 4-Vinylphenol, gamma-Sitosterol, Neophytadiene, n-Hexadecanoic acid, Octadecanoic acid, Phytol, Stigmasterol and Tetradecanoic acid possess a variety of biological qualities, including antioxidant, anti-inflammatory, anti-fungal, and anti-cancer effects.

Can Coffee Combat Fatty Liver? A Review Of Emerging Evidence, Mohamed E. Abd El-Hack, Muhammad Arif, Vincenzo Tufarelli, Ayman A. Swelum

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

NAFLD (Non-alcoholic fatty liver disease) is an increasingly spread metabolic status characterized by increasing fat accumulation in the liver, obesity closely associated with it, sedentary habits and insulin resistance. Since there is currently no recognized pharmaceutical treatment, lifestyle changes continue to be the mainstay of treatment. Coffee, a globally consumed beverage rich in bioactive and useful compounds like caffeine, cafestol, kahweol, and chlorogenic acids, has emerged as a potential hepatoprotective agent. Evidence from epidemiological experiments, animal studies, and human trials suggests that regular coffee drinking may help decrease hepatic fat levels, improve antioxidant defenses, prevent inflammatory pathways, and prevent or …

In Silico Evaluation Of Nigella Sativa Phytocompounds As Potential Modulators Of Estrogen Receptor Alpha: A Molecular Docking And Admet Study, Murtala Muhammad Jibril, Samuel Otokpa Ede, Ekwere O. Ekwere

Al-Mustaqbal Journal of Pharmaceutical and Medical Sciences

Background: Reproductive dysfunction among women remains a pressing global health issue, often linked to hormonal imbalances involving estrogen receptor alpha (ERα). Nigella sativa has garnered scientific interest due to its diverse phytochemical composition and potential reproductive health benefits. Objective: This study aimed to evaluate selected bioactive compounds from Nigella sativa oil as potential modulators of ERα using advanced computational methods. Methods: A structure-based drug discovery approach was employed. Ten phytocompounds were identified through literature mining and subjected to molecular docking against ERα. Clomiphene citrate, a known selective estrogen receptor modulator (SERM), served as the reference ligand. Binding affinities were analyzed, …

A Narrative Inquiry Of A Pre-Service Teacher In An Elementary Dhh/Hearing Setting, Emma Halliburton

The RAISE Center Journal

The text discusses the author's exploration of Deaf culture through studying Evelyn Glennie and her efforts to teach students, both Deaf and Hard of Hearing (DHH) and hearing, about the Deaf community through a narrative inquiry process. To prepare, the author completed the RedRover Reader Certification, tailored a lesson plan to teach hearing students about Deaf people, and created several data collection instruments to track the lesson’s impact on the students. The author observed the impact on DHH and hearing students. The academic and social gaps between DHH and hearing students are highlighted, as well as the need for more …

A Content Analysis Of The Reading Texts And Activities In Pupil's Book Of Action Pack 4 And Pupil's Book Of Better English Now 4 Considering The Specific Reading Outcomes Stated In The Guidelines, Ashraf Khatatbeh

Jordan Journal of Applied Science-Humanities Series

The present study aims to analyze the reading activities in the Pupil's Book of Action Pack 4 and the Pupil's Book of Better English Now 4 to determine the extent to which these activities meet the specific reading outcomes outlined in the General Guidelines and the General and Specific Outcomes for English Language in Jordan (2006). Furthermore, this study seeks to analyze the reading texts in both pupil's books to assess their authenticity. Frequencies and percentages are used to present the results of the study's questions. The analysis reveals that the reading activities in the Pupil's Book of Action Pack …

Human-Machine Communication: Complete Volume. Volume 10

Human-Machine Communication

This is the complete volume of HMC Volume 10.

Creepy, Invasive, And Exploitative Algorithms: A Cpm Analysis Of Users' Privacy Breakdowns And Recalibration Practices With Social Media Algorithms, Matthew J. A. Craig, Jeffrey T. Child

Human-Machine Communication

Social media content filtering algorithms can both provide desired personalized content and ads for users. However, sometimes these recommendations can resemble individual private information. How might users navigate these experiences to best manage their private information? The present exploratory study utilizes the rules- and systems-based framework of communication privacy management (CPM) theory to explore social media users’ experiences of privacy breakdowns with social media algorithms and investigates what users do in response to said breakdowns. These responses were refined using content analysis and divided into different categories of privacy breakdowns and recalibration strategies. Implications for future research surrounding human-machine communication …

The Hai-Io Model: A Framework For Understanding The Human-Ai Communication Process, Rae Francis Quilantang

Human-Machine Communication

The increasing integration of artificial intelligence (AI) into daily life calls for new theoretical frameworks that capture human-AI interaction’s dynamic, feedback-driven nature. Traditional models treat AI as a passive medium, overlooking its adaptive capabilities. This paper proposes the Human-AI Interaction Outcomes (HAI-IO) model, an interdisciplinary framework synthesizing human-machine communication, social exchange theory, dialogue systems, and computational feedback models like cybernetics and reinforcement learning. The HAI-IO model frames interaction as iterative and bidirectional—AI adapts through predictive processing while users adjust based on AI feedback. This mutual adaptation shapes trust, engagement, and system optimization. The model informs AI system design, user education, …

Socio-Technical Exchange With Machines: Worker Experiences With Complex Work Technologies, Cameron W. Piercy, Reaia Turner-Leatherman

Human-Machine Communication

Machines are now commonplace work partners and Human-Machine Communication (HMC) is part of modern work. Guided by the machine heuristic and Social Exchange Theory (SET) this paper uses interviews with 22 workers to explore the socio-technical relationships between humans and machines at work. Participants worked with complex machines across a wide variety of industries and roles and findings reveal participants see machines as part of the work ecosystem, develop everyday machine heuristics to guide repeated interactions with machines, and that elements of human uniqueness persist in evaluations of humans and machines. Discussion points emphasize situated and developing human-machine interaction scripts, …

Prompted By Me. Generated By Chatgpt, David J. Gunkel

Human-Machine Communication

This essay—which is not only about human-machine collaboration but is a performance in human-machine collaboration—interrogates the shifting terrain of authorship and creativity in the age of generative artificial intelligence (GAI). Challenging both the instrumentalist view of technology and the romantic myth of the singular genius, it argues for a reconceptualization of creative production as distributed, dialogical, and co-constituted. Drawing on both theoretical innovations in poststructuralism and the practices of pre- and post-modern content creators, the essay repositions the algorithm not as a mere tool but as an active participant in the generation of meaning. In doing so, it exposes and …

Being And Becoming In Human-Machine Communication: Core Commitments And Conceptual Foundations Of A Trans-Ontological Field, Autumn P. Edwards, Katrin Etzrodt

Human-Machine Communication

This introduction traces the emergence of Human-Machine Communication (HMC) as a distinct field centered on communication across ontological boundaries. Arguing that HMC is not merely about interacting with machines but about how communicative presence and legitimacy are constituted, the authors introduce the Act–Mean–Relate (AMR) paradigm to conceptualize how machines’ capacity for action, signification, and relation enable communication. HMC challenges human exceptionalism by shifting focus from internal states and categorical differences to symbolic and relational dynamics. It addresses the interpretive labor involved in making machine others intelligible and emphasizes communication as the co-construction of social reality. The article highlights tensions between …

The Emergence Of Ai Chatbots In Education, Trek Martin

Journal of Graduate Education Research

The recent advent of popular AI applications in educational contexts has sparked renewed interest in the question of AI and guided learning platforms as teaching tools. What are the possibilities for learning? In the attempt to answer that question, limitations of the field must be brought to full attention, as well an understanding of whether or not those limitations will continue into the immediate future; this research examines the technical evolution of artificial intelligence in education, from early symbolic reasoning systems to modern machine-learning-based chatbots. It then examines that evolution in terms of the key challenges it faced throughout, and …

Sevoflurane In Status Asthmaticus: A Case Report And Literature Review, Amelia L. Gurley, Thomas W. Church, Sana Hadyah, Brandon Abrajan, Julia Cheree Glavinic

HCA Healthcare Journal of Medicine

Background

Sevoflurane and other inhaled anesthetics are gradually entering provider awareness as rescue therapies for patients in refractory status asthmaticus. This paper documents a case report and a literature review involving the use of sevoflurane to treat status asthmaticus.

Case Presentation

A 27-year-old man presented to the emergency room in acute hypoxic respiratory failure due to status asthmaticus, refractory to multiple therapies and requiring intubation. He was successfully extubated following sevoflurane administration in the operating room, and his care was complicated by transient hypotension. A multidisciplinary effort was critical in ensuring successful and timely therapy.

Methods

We performed a literature …

Animal Science News (August 29, 2025), Department Of Animal Science

Animal Science Newsletters

No abstract provided.

Test-Retest Reliability Of Motor Function And Myometry Outcomes From The Vamorolone Trials In Duchenne Muscular Dystrophy, Rebecca A. Tobin, Eric P. Hoffman, Linda Johnson, Meredith K. James, Paula R. Clemens, Utkarsh J. Dang, The Vbp15-Lte And Vbp15-004 Investigators

Pharmacy Faculty Scholarship

Background and Objectives: Understanding the reliability of outcomes used in clinical care and trials is important to delineate intervention-induced change from random variability. Reliability, sensitivity, and clinical meaningfulness of change are all key aspects of choosing the most appropriate outcome measure for a clinical trial. Common outcome measures to monitor progression and treatment effect in Duchenne muscular dystrophy (DMD) include measures of strength (myometry) and motor function tests: stand from supine velocity (STANDV), North Star Ambulatory Assessment (NSAA), 6-minute walk distance (6MWD), 10-m run/walk (RWV), and 4-stair climb velocity (CLIMBV). Our objective was to present test-retest reliability of common outcome …

The Red Dusk Coffee Shop: The Application Of Tension In The Cozy Fantasy Genre, Kelli M. Lynch

Masters Theses

The purpose of this thesis is to examine the methods by which cozy fantasy writers apply literary tension within their works. Because they write within a genre that focuses on low stakes and high comfort, cozy fantasy writers must strike a balance between soothing the reader and keeping the reader interested in the narrative. The critical paper highlights several cozy fantasy writers and how they generate tension without compromising the genre-defining cozy essence. Finally, the thesis contains a complete cozy fantasy novella. The novella features Erik Juntunen, a coffee shop owner in the Keweenaw Peninsula who employs humans and figures …

An Analysis Of Feminist Biblical Scholarship Through Case Studies In Judges, Erika Conner

Masters Theses

This thesis examines the rise and significance of feminist biblical scholarship, particularly as it engages the book of Judges. Feminist approaches to Scripture have often been criticized as politically motivated or ideologically biased, yet they also claim to offer corrective readings to centuries of male-dominated interpretation. This study situates feminist scholarship within its historical development and cultural context, beginning with the reconstruction of women’s societal, familial, religious, and agricultural roles in ancient Israel. Building on this foundation, it undertakes a comparative analysis of three key figures in Judges, Deborah, Jael, and the unnamed Woman of Thebez, first through traditional interpretations …

Redesigning Responsibility: Closing The Knowledge Gap In Sustainable Design, Kaitlyn Faith Funk

Masters Theses

This thesis investigates the gap between awareness and application of sustainable practices in the graphic design industry. While sustainability has become a widely discussed topic, designers often lack accessible, practical tools to integrate it into their work. Through a combination of research, case studies, and design thinking methodologies, this project develops a comprehensive educational toolkit and accompanying campaign, ReDesigning Responsibility, that equips designers, educators, and students to make informed, environmentally responsible choices in both print and digital media. The deliverables include a printed reference guide, an interactive microsite, and a branded campaign, all aimed at fostering sustainability as a core …

Multi-Genre Storytelling: Creating An Eclectic Screenplay, Jason Daniel Faull

Masters Theses

Eclectic storytelling can encompass multiple genres. An attempt to combine the storytelling elements and genres of prequel, sequel, metafiction, and historical fiction into one story occurs in the screenplay The Legend of Eglantine Price. This screenplay is an attempt to combine successful storytelling genres to continue the story about the character Eglantine Price, created first by Mary Norton in her publication of The Magic Bed-knob (1945), and later with Walt Disney’s film adaptation Bedknobs and Broomsticks (1971). The research provided demonstrates the possibility of successfully crafting each of these genres into one screenplay which pushes the story of Eglantine, a …