Digital Commons Network^™

Successful Management Of Feline Gastrointestinal Eosinophilic Sclerosing Fibroplasia With Mycophenolate Mofetil And Prednisolone Following Surgical Resection In A Cat, Min-Soo Kim, Keon Kim, Gwang-Hyun Lee, Cheol-Hyun Kim, Seo-Lin Jang, Guk-Hyun Suh, Chang-Min Lee

The Thai Journal of Veterinary Medicine

A 1-year-old castrated male Ragdoll who showed a series of vomiting and had reduced appetite presented to a local animal hospital. Hyperthermia and tachypnea were observed in physical examination, and leukocytosis was detected in hematological examination. Abdominal ultrasonography revealed an intramural mass with irregular echogenicity extending from the pylorus to the duodenum and loss of intestinal wall layer with regional lymph node enlargement. After exploratory laparotomy for biopsy and symptomatic alleviation, histopathological evaluation revealed densely infiltrated eosinophils within the branching and anastomosing trabecular pattern of collagen by several spindle-shaped cells. Finally, the patient was diagnosed with feline gastrointestinal eosinophilic sclerosing …

Successful Treatment Of Demodicosis Due To Demodex Cati In A Cat Using Spot – On Formulation Of Fluralaner, Piyarat Chansiripornchai, Niwat Chansiripornchai

The Thai Journal of Veterinary Medicine

This case report describes the successful use of fluralaner in treating demodicosis caused by Demodex cati in a cat. A 4.2 kg 10 – year – old spayed female Siamese short – haired cat was presented with a 5 – month history of severe dermatitis. The cat had been treated at previous animal hospitals with a variety of drugs such as antimicrobials, glucocorticoids and ectoparasiticides on separate occasions but the clinical signs remained severe. Microscopic examination of skin samples revealed the presence of D. cati. The cat was treated with a single dose of spot – on formulation of fluralaner …

Petsmart, Inc. V. Dist. Ct. (Todd), 137 Nev. Adv. Op. 75 (Dec. 9, 2021), Brenna Irving

Nevada Supreme Court Summaries

No abstract provided.

Hydrothermal Processes For Extraction And Conversion Of Biomass To Produce Biofuels And Value-Added Products, Anuj Hemant Thakkar

Civil & Environmental Engineering Theses & Dissertations

An integrated biorefinery approach based on subcritical hydrothermal processes was developed to maximize utilization of biomass components by producing multiple products. Biomass from various sources like agricultural waste (lignocellulose), food waste (spent yeast), and dedicated cultivation (micro-algae) was used in this research.

Corn stover (agricultural waste) was hydrothermally pretreated to remove lignin and xylan while preserving most of the glucan. The pretreated corn stover was utilized to produce levulinic acid (thermochemically) and fermentable sugars (biochemically). The solid residue generated during levulinic acid production was utilized to produce biocarbon electrode material. The results generated from the experiments were used for designing …

Tunable Compressive Mechanical Behavior Of Ice-Templated Materials, Sashanka Akurati

Mechanical & Aerospace Engineering Theses & Dissertations

The inherent hierarchical microstructural organization in natural materials is responsible for their excellent mechanical properties beyond that predicted by the simple rule-of-mixtures. Further exhibit synergy between strength and toughness, otherwise mutually exclusive in brittle materials. Conventional processing methods are unable to replicate hierarchical microstructures in engineering ceramics akin to that observed in natural materials. Ice-templating has emerged as a potential technique to fabricate bioinspired hierarchical materials. This process involves simultaneous unidirectional solidification and phase segregation of aqueous suspensions. Ice-templated porous ceramic materials have received significant attention for overcoming several limitations of conventional ceramic foams currently used in numerous engineering applications. …

Elementary Classroom Teachers’ Perceptions Of Redesigned Classroom Space: A Qualitative Case Study, Kristin Lee Pender

Teaching & Learning Theses & Dissertations

Classroom redesign is being recognized globally as necessary to better increase student’s enjoyment levels, engagement, collaboration, and learning. Instead of seeing traditional classrooms in a fixed setting where students are seated in rows facing the front of the room, classrooms are being arranged in multiple ways. As a result of this focus on redesigned learning spaces, there is a need to examine teachers’ perceptions about redesigned classroom spaces and understand the decisions behind their design. Thus, it is important to examine teachers’ perceptions of their classroom space to better understand if they consider their students learning needs, engagement levels, and …

An Experimental Investigation Into The Impact Of Acute Stress On Alcohol Craving Through Implicit Coping Motives, Douglas J. Glenn

Psychology Theses & Dissertations

Drinking to cope with negative emotions is associated with many negative alcohol-related outcomes such as increased alcohol use, drinking-related problems, and alcohol use disorders. An acute stressor is one example of a stimulus leading to negative emotions that an individual may wish to avoid. Research has shown that acute stress positively relates to drinking. Specifically, previous experimental studies have shown that individuals exposed to a stressor drink more alcohol and have stronger urges to drink than those not exposed to a stressor. Thus, it may be that drinking to cope explains why people experience alcohol cravings after experiencing a stressor. …

Emergency Clinicians' Perceptions Of Communication Tools To Establish The Mental Baseline Of Older Adults: A Qualitative Study, Anita Chary, Christopher Joshi, Noelle Castilla-Ojo, Ilianna Santangelo, Kei Ouchi, Aanand D. Naik, Christopher R. Carpenter, Shan W Liu, Maura Kennedy

2020-Current year OA Pubs

Background Evaluating older adults with altered mental status in emergency settings can be challenging due to the inability to obtain a history from patients directly and limited collateral information about the change from a patient's mental status baseline. Documents and videos establishing a patient's mental baseline could represent useful communication tools to aid emergency clinicians. Methods Qualitative interviews conducted with 22 emergency clinicians (12 physicians and 10 advanced practice providers) identified methods they use to determine baseline mental status of older adults in the ED and the perceived utility of document- and video-based information about an older adult's baseline mental …

A Brief History Of Nearly Ev-Erything - The Rise And Rise Of Extracellular Vesicles, Yvonne Couch, Edit I Buzàs, Dolores Di Vizio, Yong Song Gho, Paul Harrison, Andrew F Hill, Jan Lötvall, Graça Raposo, Philip D Stahl, Clotilde Théry, Kenneth W Witwer, David R F Carter

2020-Current year OA Pubs

Extracellular vesicles (EVs) are small cargo-bearing vesicles released by cells into the extracellular space. The field of EVs has grown exponentially over the past two decades; this growth follows the realisation that EVs are not simply a waste disposal system as had originally been suggested by some, but also a complex cell-to-cell communication mechanism. Indeed, EVs have been shown to transfer functional cargo between cells and can influence several biological processes. These small biological particles are also deregulated in disease. As we approach the 75th anniversary of the first experiments in which EVs were unknowingly isolated, it seems right to …

Ogden Type I To Iii Tibial Tubercle Fractures In Skeletally Immature Patients: Is Routine Anterior Compartment Fasciotomy Of The Leg Indicated?, Corey Brown, Brian A. Kelly, Kirsten Brouillet, Scott J. Luhmann

2020-Current year OA Pubs

PURPOSE: Determine the frequency of compartment syndrome of the leg after displaced, operatively treated modified Ogden I to III tibial tubercle fractures (TTFxs), evaluate the preoperative assessment and use of advanced imaging, and need for prophylactic fasciotomies.

METHODS: Retrospective analysis of operatively treated, displaced modified Ogden I to III TTFxs, at our level 1 paediatric trauma centre between 2007 and 2019. Modified Ogden Type IV and V fracture patterns were excluded. Fracture patterns were determined by plain radiographs.

RESULTS: There were 49 modified Ogden I to III TTFxs in 48 patients. None had signs nor symptoms of vascular compromise, compartment …

In The Beginning: Genesis 1-3 And Its Significance To The Latter-Day Saints, Dan Belnap, Daniel L. Belnap

Faculty Publications

This volume begins with the same event the Bible itself does—the Creation. The Creation narrative and the Garden of Eden narrative that immediately follows have been the subject of much study throughout the years. Over the past century, particular attention has been given to the similarities between it and other ancient Near Eastern Creation narratives. For Latter-day Saints, the Creation and Garden of Eden narratives play central roles in their worship practices, the narratives themselves laying down the plan of salvation God ordained for all his children. In this first chapter, Dan Belnap describes what creation meant to those of …

Single-Cell Rna-Sequencing Analysis Of The Ciliary Epithelium And Contiguous Tissues In The Mouse Eye, J C Youkilis, S Bassnett

2020-Current year OA Pubs

The ciliary epithelium plays a central role in ocular homeostasis but cells of the pigmented and non-pigmented layers are difficult to isolate physically and study. Here we used single-cell RNA-sequencing (scRNA-seq) to analyze the transcriptional signatures of cells harvested from the ciliary body and contiguous tissues. Microdissected tissue was dissociated by collagenase digestion and the transcriptomes of individual cells were obtained using a droplet-based scRNA-seq approach. In situ hybridization was used to verify the expression patterns of selected differentially-expressed genes. High quality transcriptomes were obtained from 10,024 cells and unsupervised clustering distinguished 22 cell types. Although efforts were made to …

Poultry Producer's Willingness To Invest In On-Farm Carcass Disposal, V. L. Campbell, J. M. Thompson, J. L. Apriesnig, D. L. Pendell, G. T. Tonsor

Michigan Tech Publications, Part 1

Foreign animal diseases (FAD) can cause substantial economic losses in production, consumption, and the supply chain. These diseases are typically highly pathogenic and lead to disruptions in normal business practices and to demands for higher investment in biosecurity practices. For poultry producers this can lead to changes in bird pick-ups, chick placements, and length of out time on farms as well as changes in day-to-day operations. When an FAD is reported, poultry producers that rely on off-premises carcass disposal (e.g., renderers or landfills) may be required to develop on-farm disposal capacity (e.g., incinerators or burial) rapidly if their operation falls …

Erratum: Physicochemical Insights Of Irradiation-Enhanced Hydroxyl Radical Generation From Zno Nanoparticles(Toxicology Research Doi: 10.1039/C5tx00384a), Qingbo Yang, Tien Sung Lin, Casey Burton, Sungho Park, Yinfa Ma

Electrical and Computer Engineering Faculty Research & Creative Works

In the originally published version of this manuscript, the fourth author's name is incorrect. The name should read "Sungho Park", instead of "Sung-Ho Park". These details have been corrected only in this corrigendum to preserve the published version of record.

Etherlearn: Decentralizing Learning Via Blockchain, Nguyen Binh Duong Ta, Tian Jun Joel Yang

Research Collection School Of Computing and Information Systems

In institutes of higher learning, most of the time course material development and delivery follow a centralized model which is fully lecturer-controlled. In this model, engaging students as partners in learning is a challenging problem as: 1) students are usually hesitant to contribute due to the fear of getting it wrong, 2) not much incentive for them to put in the extra effort, and 3) current online learning systems lack adequate facilities to support seamless and anonymous interactions between students. In this work, we propose EtherLearn, a blockchain based peer-learning system to distribute the control of how course material and …

Host Defence Peptides In Diabetes Mellitus Type 2 Patients With Periodontal Disease. A Systematic Review, Muhammad Saad Shaikh, Muhammad Sohail Zafar, Farhan Saleem, Ahmad Alnazzawi, Mohid Abrar Lone, Syed Jawad Ali Bukhari, Zohaib Khurshid

Research outputs 2014 to 2021

The aim of the study was to critically assess and review the latest evidence relating the associations between host defence peptides (HDPs), periodontal diseases (PD) and diabetes mellitus type 2 (DM2). To explore studies on HDPs, periodontal disease, and DM2, researchers utilised specific key phrases to search the electronic databases PubMed (National Library of Medicine), Embase (Ovid), Medline (EBSCO), and Dentistry and Oral Sciences (EBSCO). Quality assessment was conducted by means of the Newcastle Ottawa scale and the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Following a thorough screening process, a total of 12 papers (4 case‐control, 6 …

Personality As A Predictor Of Patterns Of Substance Use, Cynthia Sergi

LSU New Orleans Theses and Dissertations

Substance use (SU) affects many people worldwide and is an important public health concern. Personality has been theorized to play a crucial role in the development and maintenance of SU. To test how personality is related to patterns of SU, a latent profile analysis was used to cluster individuals into SU classes with multinomial logistic regression used to test the relationship between personality and patterns of SU. Results suggested that polysubstance use was common, with variations in primary substance of choice among classes. As classes became more inclusive of more substances, they increased in psychopathological personality traits. Higher domains of …

Immobilized Lipase On Zif For Enhanced Biofuel Production, Reem Mohammed Al Mansouri

Theses

Enzymatic transesterification of triglycerides to produce biodiesel has been gaining increasing attention owing to its advantages over chemical processes. Being catalysts, enzymes are not consumed during the processes in which they are used. Therefore, a successful technique to allow their repeated use can significantly enhance the economic feasibility of the process. The most common approach to allow easy separation of the enzymes and to eliminate their wastage is immobilization on a support matrix. Recently, Metal-Organic Frameworks (MOFs) have been suggested as preferable support for enzyme immobilization, owing to their high-order structure and high porosity and specific surface area. This thesis …

The Impact Of Wastewater Chemistry And Flow Characteristics On Hydrogen Sulfide Concentration, Mohsina Muhammed Sherief

Theses

Hydrogen sulfide (H₂S) is a naturally occurring, highly toxic gas that is formed from the decomposition of sulfur compounds. At low concentrations, H₂S is an irritant for the eyes, respiratory and gastrointestinal tract. At higher H₂S concentrations, it produces neurological impairment with dizziness, headache, and loss of consciousness. Mortality was reported to reach 6 percent following exposure to elevated concentrations. H₂S is generated in different industrial processes. In wastewater collection and treatment plants, H₂S is a common source of concrete and metal corrosion that has resulted in huge economic loss. …

Elucidation Of The Cellular Mechanisms Underlying Missense Mutations In Low Density Lipoprotein Receptor Related Protein 6 (Lrp6) Associated With Cardiovascular Diseases, Huda Issa Samha

Theses

Low-density Lipoprotein Receptor Related Protein 6 (LRP6) is a member of the Low-Density Lipoprotein Receptors family (LDLRs) which is involved in the clearance of LDL from the bloodstream and the signaling of the canonical wingless signaling pathway. Several genetic variants in the LRP6 gene have been conclusively associated with cardiovascular diseases (CVDs) and metabolic syndrome. However, the structural and functional implications of those variations have not been fully elucidated. The CVD-associated LRP6 variants could be retained and possibly subjected to Endoplasmic Reticulum Associated Degradation (ERAD), a quality control and adaptive process employed by cells to eliminate misfolded proteins to maintain …

Reflections On The Phoenician Alphabet: Property And Its Defense In The Origin And Order Of The Letters (Draft #3), Gerald Leonard Cohen

Arts, Languages and Philosophy Faculty Research & Creative Works

No abstract provided.

A Meta-Analysis Of Three Years Of Data On Outcomes Of Therapy Groups For Inmates In The Virginia Department Of Corrections, Abie Carroll Tremblay

Counseling & Human Services Theses & Dissertations

The Virginia Department of Corrections (VADOC) is responsible for about 28,000 inmates and 66,000 probationers and parolees annually. Mental health services are often conducted through therapeutic groups, many of which are manualized and based in cognitive behavioral therapy theory. In the three years, 2017 through 2019, VADOC conducted 172 therapeutic group therapy studies, and the resulting data, in the form of t-test scores, were made available for academic research. This meta-analysis investigated whether cognitive behavioral group therapy produced superior outcomes when compared to other theoretical orientations in group therapy in VADOC, if manualized group therapy treatments produced superior outcomes when …

A Testing And Experimenting Environment For Microscopic Traffic Simulation Utilizing Virtual Reality And Augmented Reality, Mahmud Hasan

Computational Modeling & Simulation Engineering Theses & Dissertations

Microscopic traffic simulation (MTS) is the emulation of real-world traffic movements in a virtual environment with various traffic entities. Typically, the movements of the vehicles in MTS follow some predefined algorithms, e.g., car-following models, lane changing models, etc. Moreover, existing MTS models only provide a limited capability of two- and/or three-dimensional displays that often restrict the user’s viewpoint to a flat screen. Their downscaled scenes neither provide a realistic representation of the environment nor allow different users to simultaneously experience or interact with the simulation model from different perspectives. These limitations neither allow the traffic engineers to effectively disseminate their …

The Spooky Vein: The Reparative Gothic-Modern In The Works Of Richard A.W. Hughes, Corwin R. Baden

English Theses & Dissertations

This dissertation explores the dual nature of Richard A.W. Hughes as a marginalized Gothicist and modernist. This duality facilitated the development of the author’s reparative vision for a 20th-century world traumatized by planetary war. The present study utilizes close readings—both surface and symptomatic—combined with archival research to assert that Hughes fashions this reparative imperative consistently across his corpus: in his short stories, poems, novels, stage plays, and screenplays. In his short stories, this vision includes an embrace of the Stranger, a shadowy Gothic figure whose possessions, power, difference, and familiarity lead the human subject from contestation, through representation, and toward …

Phytoplankton Community Response To Upwelling Events: Distribution And Abundance Investigated Using Genomic Methods, Sveinn V. Einarsson

OES Theses and Dissertations

Upwelling events are known to support blooms of phytoplankton, important primary producers at the base of the oceanic food web. Phytoplankton community structure changes in response to upwelling support higher trophic level growth and increased efficiency of carbon export from the euphotic zone. While these events occur globally, this study examined upwelling in coastal regions, where alongshore winds can drive Ekman transport and upwelling of deeper waters. The two upwelling regimes examined were the California Current System and the Alaskan Beaufort Sea. In the California Current System, the relative diatom community composition was examined using 18S sequencing to determine how …

The Investigations Of Nps Modulated Immunity And Immunometabolism, Brittney Leigh Ruedlinger

Biomedical Sciences Theses & Dissertations

Cancers remain in the top noncommunicable diseases responsible for premature mortality. The heterogeneity among cancers and within tumors makes treating them ever more challenging. Our misfortune for developing cures is mocked by cancer, with the lowest probability of success (PoS) through clinical trials and FDA approval. At the basic level, there are generally two broad gaps impeding cancer eradication: the unidentified shared mechanism(s) exploited by all cancers and the therapeutic approach to intervene. Nanosecond pulse stimulation (NPS) offers a unique approach since its broad impacts intersect those often hijacked by oncogenesis. Metabolic pathways, known for dysfunctions among cancers, share a …

A Copula Model Approach To Identify The Differential Gene Expression, Prasansha Liyanaarachchi

Mathematics & Statistics Theses & Dissertations

Deoxyribonucleic acid, more commonly known as DNA, is a complex double helix-shaped molecule present in all living organisms and hosts thousands of genes. However, only a few genes exhibit differential expression and play a vital role in a particular disease such as breast cancer. Microarray technology is one of the modern technologies developed to study these gene expressions. There are two major microarray technologies available for expression analysis: Spotted cDNA array and oligonucleotide array. The focus of our research is the statistical analysis of data that arises from the spotted cDNA microarray. Numerous models have been proposed in the literature …

Whole-Genome Association Analyses Of Sleep-Disordered Breathing Phenotypes In The Nhlbi Topmed Program, Brian E. Cade, Brian E. Cade, Jiwon Lee, Tamar Sofer, Heming Wang, Man Zhang, Han Chen, John Blangero, Joanne E. Curran, Juan M. Peralta

School of Medicine Publications

Background: Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing. Methods: The study sample was comprised of 7988 individuals of diverse ancestry. Common-variant and pathway analyses included an additional 13,257 individuals. We examined five complementary traits describing different aspects of sleep-disordered breathing: the apnea-hypopnea index, average oxyhemoglobin desaturation per event, average and minimum oxyhemoglobin saturation across the sleep episode, and the percentage of sleep with oxyhemoglobin saturation < 90%. We adjusted for age, sex, BMI, study, and family structure using MMSKAT and EMMAX mixed linear model approaches. Additional bioinformatics analyses were performed with MetaXcan, GIGSEA, and ReMap. Results: We identified a multi-ethnic set-based rare-variant association (p = 3.48 × 10−8) on chromosome X with ARMCX3. Additional rare-variant associations include ARMCX3-AS1, MRPS33, and C16orf90. Novel common-variant loci were identified in the NRG1 and SLC45A2 regions, and previously associated loci in the IL18RAP and ATP2B4 regions were associated with novel phenotypes. Transcription factor binding site enrichment identified associations with genes implicated with respiratory and craniofacial traits. Additional analyses identified significantly associated pathways. Conclusions: We have identified the first gene-based rare-variant associations with objectively measured sleep-disordered breathing traits. Our results increase the understanding of the genetic architecture of sleep-disordered breathing and highlight associations in genes that modulate lung development, inflammation, respiratory rhythmogenesis, and HIF1A-mediated hypoxic response.

Interaction Between Alcohol Consumption And Pnpla3 Variant In The Prevalence Of Hepatic Steatosis In The Us Population, Mariana Lazo, Usama Bilal, Mack C Mitchell, James Potter, Ruben Hernaez, Jeanne M Clark

Faculty, Staff and Students Publications

BACKGROUND & AIMS: To our knowledge, the interaction between alcohol consumption and PNPLA3 genotype on hepatic steatosis has not been explored in a representative sample. To examine the interaction between alcohol consumption and PNPLA3 genotype on hepatic steatosis in the US adult population.

METHODS: Cross-sectional study of 4,674 adult participants of the Third National Health and Nutrition Examination Survey, Phase 2 (1991-1994) with data on PNPLA3 genotype, self-reported alcohol consumption, ultrasound-defined hepatic steatosis and socio-demographic characteristics.

RESULTS: In 1991-1994 in the U.S. population, the weighted allele frequency of the G (risk) allele of the rs738409 at PNPLA3 was 25.4%. We …

Habitat And Environmental Risks Of Chagas Disease In Low-Income Colonias And Peri-Urban Subdivisions In South Texas, Bára Šafářová, Cecilia H. Giusti, Maria P. Perez, Italo B. Zecca, Ester S. Carbajal, Gabriel L. Hamer, Sarah A. Hamer

School of Medicine Publications

Both the planning and public health literature have discussed proximity to greenspaces as predominantly beneficial to health, based on studies mostly conducted in high-income regions. Understanding the health risks of proximity to greenspace and nature—where pathogens and wildlife coexist—is important, as nature-based solutions are increasingly called for to address complex urban challenges. This exploratory pilot study bridges planning and epidemiology approaches to develop a new method to analyze habitat and environmental factors associated with the risk of vector-borne Chagas disease in a low-income region, South Texas. Chagas disease is endemic in Latin America, where it affects between seven to eight …