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2021

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Articles 1921 - 1950 of 24293

Full-Text Articles in Entire DC Network

Emergency Clinicians' Perceptions Of Communication Tools To Establish The Mental Baseline Of Older Adults: A Qualitative Study, Anita Chary, Christopher Joshi, Noelle Castilla-Ojo, Ilianna Santangelo, Kei Ouchi, Aanand D. Naik, Christopher R. Carpenter, Shan W Liu, Maura Kennedy Dec 2021

Emergency Clinicians' Perceptions Of Communication Tools To Establish The Mental Baseline Of Older Adults: A Qualitative Study, Anita Chary, Christopher Joshi, Noelle Castilla-Ojo, Ilianna Santangelo, Kei Ouchi, Aanand D. Naik, Christopher R. Carpenter, Shan W Liu, Maura Kennedy

2020-Current year OA Pubs

Background Evaluating older adults with altered mental status in emergency settings can be challenging due to the inability to obtain a history from patients directly and limited collateral information about the change from a patient's mental status baseline. Documents and videos establishing a patient's mental baseline could represent useful communication tools to aid emergency clinicians. Methods Qualitative interviews conducted with 22 emergency clinicians (12 physicians and 10 advanced practice providers) identified methods they use to determine baseline mental status of older adults in the ED and the perceived utility of document- and video-based information about an older adult's baseline mental …

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Survivals Of Two Cooperating Species Of Animals, Joon Hyuk Kang Dec 2021

Survivals Of Two Cooperating Species Of Animals, Joon Hyuk Kang

Faculty Publications

The purpose of this paper is to give conditions for the existence and uniqueness of positive solution to a rather general type of elliptic system of the Dirichlet problem on a bounded domain Ω" role="presentation" style="box-sizing: border-box; margin: 0px; padding: 0px; display: inline-block; line-height: normal; font-size: 16.2px; word-spacing: normal; overflow-wrap: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; position: relative;">Ω in Rn" role="presentation" style="box-sizing: border-box; margin: 0px; padding: 0px; display: inline-block; line-height: normal; font-size: 16.2px; word-spacing: normal; overflow-wrap: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: …

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Promoting Employer Desired Competencies Through A Multiphased "Workgroup" Project, Ashly Smith Dec 2021

Promoting Employer Desired Competencies Through A Multiphased "Workgroup" Project, Ashly Smith

International Journal for Business Education

Employers and business leaders have long been advocating for the importance of career readiness skills like critical thinking/problem solving, information literacy, teamwork/collaboration, professionalism/work ethic, and oral/written communication (NACE, 2019; Partnership, 2008). While faculty and students see value in projects that develop these skills, such projects can be some of the most challenging to incorporate effectively into business courses (Chapman et al., 2010; Detmering & Johnson, 2012; Lee et al., 2016; Marks & O’Connor, 2013). This article reports on a multi-phase group project that aims to strengthen a selection of these employer-desired skills while ameliorating student concerns about the research process …

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Species And Population Specific Gene Expression In Blood Transcriptomes Of Marine Turtles, Shreya M. Banerjee, Jamie Adkins Stoll, Camryn D. Allen, Jennifer M. Lynch, Heather S. Harris, Lauren Kenyon, Richard E. Connon, Eleanor J. Sterling, Eugenia Naro-Maciel, Kathryn Mcfadden, Margaret M. Lamont, James Benge, Nadia B. Fernandez, Jeffrey A. Seminoff, Scott R. Benson, Rebecca L. Lewison, Tomoharu Eguchi, For Full Author List, See Comments Below Dec 2021

Species And Population Specific Gene Expression In Blood Transcriptomes Of Marine Turtles, Shreya M. Banerjee, Jamie Adkins Stoll, Camryn D. Allen, Jennifer M. Lynch, Heather S. Harris, Lauren Kenyon, Richard E. Connon, Eleanor J. Sterling, Eugenia Naro-Maciel, Kathryn Mcfadden, Margaret M. Lamont, James Benge, Nadia B. Fernandez, Jeffrey A. Seminoff, Scott R. Benson, Rebecca L. Lewison, Tomoharu Eguchi, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

Background: Transcriptomic data has demonstrated utility to advance the study of physiological diversity and organisms’ responses to environmental stressors. However, a lack of genomic resources and challenges associated with collecting high-quality RNA can limit its application for many wild populations. Minimally invasive blood sampling combined with de novo transcriptomic approaches has great potential to alleviate these barriers. Here, we advance these goals for marine turtles by generating high quality de novo blood transcriptome assemblies to characterize functional diversity and compare global transcriptional profiles between tissues, species, and foraging aggregations. Results: We generated high quality blood transcriptome assemblies for hawksbill (Eretmochelys …

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Runs Of Homozygosity In Killer Whale Genomes Provide A Global Record Of Demographic Histories, Andrew D. Foote, Rebecca Hooper, Alana Alexander, Robin W. Baird, Charles Scott Baker, Lisa Ballance, Jay Barlow, Andrew Brownlow, Tim Collins, Rochelle Constantine, Luciano Dalla Rosa, Nicholas J. Davison, John W. Durban, Ruth Esteban, Laurent Excoffier, Sarah L.Fordyce Martin, Karin A. Forney, For Full Author List, See Comments Below Dec 2021

Runs Of Homozygosity In Killer Whale Genomes Provide A Global Record Of Demographic Histories, Andrew D. Foote, Rebecca Hooper, Alana Alexander, Robin W. Baird, Charles Scott Baker, Lisa Ballance, Jay Barlow, Andrew Brownlow, Tim Collins, Rochelle Constantine, Luciano Dalla Rosa, Nicholas J. Davison, John W. Durban, Ruth Esteban, Laurent Excoffier, Sarah L.Fordyce Martin, Karin A. Forney, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

Runs of homozygosity (ROH) occur when offspring inherit haplotypes that are identical by descent from each parent. Length distributions of ROH are informative about population history; specifically, the probability of inbreeding mediated by mating system and/or population demography. Here, we investigated whether variation in killer whale (Orcinus orca) demographic history is reflected in genome-wide heterozygosity and ROH length distributions, using a global data set of 26 genomes representative of geographic and ecotypic variation in this species, and two F1 admixed individuals with Pacific-Atlantic parentage. We first reconstructed demographic history for each population as changes in effective population size through time …

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A Brief History Of Nearly Ev-Erything - The Rise And Rise Of Extracellular Vesicles, Yvonne Couch, Edit I Buzàs, Dolores Di Vizio, Yong Song Gho, Paul Harrison, Andrew F Hill, Jan Lötvall, Graça Raposo, Philip D Stahl, Clotilde Théry, Kenneth W Witwer, David R F Carter Dec 2021

A Brief History Of Nearly Ev-Erything - The Rise And Rise Of Extracellular Vesicles, Yvonne Couch, Edit I Buzàs, Dolores Di Vizio, Yong Song Gho, Paul Harrison, Andrew F Hill, Jan Lötvall, Graça Raposo, Philip D Stahl, Clotilde Théry, Kenneth W Witwer, David R F Carter

2020-Current year OA Pubs

Extracellular vesicles (EVs) are small cargo-bearing vesicles released by cells into the extracellular space. The field of EVs has grown exponentially over the past two decades; this growth follows the realisation that EVs are not simply a waste disposal system as had originally been suggested by some, but also a complex cell-to-cell communication mechanism. Indeed, EVs have been shown to transfer functional cargo between cells and can influence several biological processes. These small biological particles are also deregulated in disease. As we approach the 75th anniversary of the first experiments in which EVs were unknowingly isolated, it seems right to …

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Single-Cell Rna-Sequencing Analysis Of The Ciliary Epithelium And Contiguous Tissues In The Mouse Eye, J C Youkilis, S Bassnett Dec 2021

Single-Cell Rna-Sequencing Analysis Of The Ciliary Epithelium And Contiguous Tissues In The Mouse Eye, J C Youkilis, S Bassnett

2020-Current year OA Pubs

The ciliary epithelium plays a central role in ocular homeostasis but cells of the pigmented and non-pigmented layers are difficult to isolate physically and study. Here we used single-cell RNA-sequencing (scRNA-seq) to analyze the transcriptional signatures of cells harvested from the ciliary body and contiguous tissues. Microdissected tissue was dissociated by collagenase digestion and the transcriptomes of individual cells were obtained using a droplet-based scRNA-seq approach. In situ hybridization was used to verify the expression patterns of selected differentially-expressed genes. High quality transcriptomes were obtained from 10,024 cells and unsupervised clustering distinguished 22 cell types. Although efforts were made to …

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Direct Drilling Of Soybean In A Pensacola Bahiagrass Pasture In The Northwest Region Of Rio Grande Do Sul, Brazil, R. B. Medeiros, J. Riboldi, J. C. De Saibro, J. E. G. Zambra Nov 2021

Direct Drilling Of Soybean In A Pensacola Bahiagrass Pasture In The Northwest Region Of Rio Grande Do Sul, Brazil, R. B. Medeiros, J. Riboldi, J. C. De Saibro, J. E. G. Zambra

IGC Proceedings (1977-2023)

The response of methods of soil preparation (M1=conventional tillage, and with notillage using the following herbicides M2=50% Paraquat plus 50% Orizalin; M3=50% Paraquat plus 50% Diquat and M4=Paracol (20% Paraquat plus 20 Diuron)) and row spacing (E1=17 cm, E2=24 cm, E3=51 cm and E4=68 cm) on soybean grain yield direct drilled in an eight-year-old grazed sward of Bahiagrass cv. Pensacola (Paspalum notatum var. saurae Parodi) were studied in southern of Brazil. The results showed that direct drilling of soybean on Pensacola accompanied by …

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Mission And Mundialización: Solidarity And Global Citizenship Through Immersion Experiences, Katherine Brown, Elizabeth C. Reilly Nov 2021

Mission And Mundialización: Solidarity And Global Citizenship Through Immersion Experiences, Katherine Brown, Elizabeth C. Reilly

Jesuit Higher Education: A Journal

Within the Jesuit educational network, each institution’s mission informs not only its curricular and co-curricular offerings for students, but a variety of programs for faculty, staff, administrators, and all community members. In recent decades, the Society of Jesus has also spoken with increasing emphasis on the importance of forming whole persons of solidarity for the real world. This paper explores how the call to forming well-educated persons of solidarity intersects with Loyola Marymount University’s specific institutional mission and its formation programs for university personnel, and how this intersection is particularly well-addressed by immersion experiences and especially international immersions. Finally, suggestions …

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Discernment As An Apostolic Preference: Ignatius, Patanjali, And The Fostering Of Interior Freedom, Mark Graceffo Nov 2021

Discernment As An Apostolic Preference: Ignatius, Patanjali, And The Fostering Of Interior Freedom, Mark Graceffo

Jesuit Higher Education: A Journal

For the next ten years, the Society of Jesus will immerse themselves in what they have identified as their Universal Apostolic Preferences. In this paper, I will focus on the first of these preferences, “Promoting Discernment and the Spiritual Exercises.” I propose that Saint Ignatius’ teaching on discernment intersects with and can be complemented by teachings on the same subject (viveka) by Sri Patanjali in the Yoga Sutras. Both of these masterful works offer a practical and experiential path to liberating ourselves from the obstacles that impede us from knowing our True Selves as beings who dwell in …

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Reciprocal Relationships: Ajcu Presidents & Rectors, Jeffrey Labelle S.J., Daniel Kendall S.J. Nov 2021

Reciprocal Relationships: Ajcu Presidents & Rectors, Jeffrey Labelle S.J., Daniel Kendall S.J.

Jesuit Higher Education: A Journal

This study reviews literature pertinent to the changing landscape of leadership at member institutions of higher education in the Association of Jesuit Colleges and Universities (AJCU) with a view toward revisioning the relationship between presidents and Jesuit superiors. The purpose of this article encourages efforts to foster Jesuit mission and identity during a shift toward increased lay leadership. The research cites related insights from previous studies and mandates from documents of the Society of Jesus that together point to the need for reimagining leadership. The study underscores the importance of fostering relationships of mutuality and reciprocity to ensure the sustaining …

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Encountering Grace: A Theological Framework For Faculty And Staff Immersion Programs, John T. Sebastian Ph.D. Nov 2021

Encountering Grace: A Theological Framework For Faculty And Staff Immersion Programs, John T. Sebastian Ph.D.

Jesuit Higher Education: A Journal

Many international and domestic immersion programs for faculty and staff at Jesuit colleges and universities in the United States have in common the goal of promoting participants’ solidarity with poor and marginalized populations. These programs often understand solidarity as a pedagogical instrument: direct contact with human suffering provokes a desire to think and act differently in order to redress various forms of social inequity. This essay proposes that immersions can and should also be opportunities for engaging faculty and staff at Jesuit institutions of higher education in conversations about, and even experiences of, social grace. The paper offers an overview …

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Forage Quality Evaluation Of Chopped Elephantgrass Hay Through Intake And Digestibility Trial, E. M. De Aguiar, G. F. Da C. Lima, L. G. Da Paz Nov 2021

Forage Quality Evaluation Of Chopped Elephantgrass Hay Through Intake And Digestibility Trial, E. M. De Aguiar, G. F. Da C. Lima, L. G. Da Paz

IGC Proceedings (1977-2023)

The research was carried out to evaluate forage quality of chopped elephantgrass (Pennisetum purpureum Schum.) hay and to define a proper stage for cutting and haymaking of this grass. Chemical composition, voluntary intake, and apparent digestibility of the hays were studied at five different growth stages (30, 48, 63, 76, and 91 days). Twenty-five common wethers were utilized in a completely randomized experimental design. Dry matter (DM) voluntary intake was not different (P> 0.05) from 30 to 63 days of regrowth and from 63 to 91 days and comprised 3.9; 3.5; 3.2; 2.1; and 2.4% of animal liveweight, respectively …

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Amphibians And Reptiles As Prey Of Heteroctenus Junceus (Scorpiones: Buthidae), With A Summary Of Vertebrate Predation By Scorpions In The West Indies, Tomás M. Rodríguez-Cabrera,, Ernesto Morell Savall, Rolando Teruel Nov 2021

Amphibians And Reptiles As Prey Of Heteroctenus Junceus (Scorpiones: Buthidae), With A Summary Of Vertebrate Predation By Scorpions In The West Indies, Tomás M. Rodríguez-Cabrera,, Ernesto Morell Savall, Rolando Teruel

Euscorpius

Vertebrate predation by scorpions has been scarcely documented in the literature. Contrary to large scorpions of the genera Centruroides, Hadrurus, Opistophthalmus, and Pandinurus from North America and Africa, which are capable of subduing even small rodents and bats, West Indian scorpions of the genera Centruroides, Heteroctenus, and Tityus seem to limit their prey to amphibians and reptiles. Herein we present new cases of a frog (Osteopilus septentrionalis; Hylidae) and three lizards (Anolis allisoni, A. ophiolepis, and A. sagrei; Dactyloidae) preyed upon by Heteroctenus junceus (Herbst, 1800), at the time we summarize all cases of vertebrate …

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Contributors' Notes Nov 2021

Contributors' Notes

Exile

No abstract provided.

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Coding Human-Animal Interactions In Homes Of Children With Autism Spectrum Disorders, Caitlin Lisk, Lisa Ann Mische Lawson Nov 2021

Coding Human-Animal Interactions In Homes Of Children With Autism Spectrum Disorders, Caitlin Lisk, Lisa Ann Mische Lawson

People and Animals: The International Journal of Research and Practice

Autism spectrum disorder (ASD) is a developmental disorder characterized by differences in social functioning, communication, sensory preferences, and behavior. These differences invite an effort to understand the human-animal bond and its impact on families and children with ASD. The purpose of this study was to determine if the Observation of Human-Animal Interaction for Research (OHAIRE) coding tool can be utilized in a home-based setting to code human-animal interactions in children with ASD. The OHAIRE is a coding tool developed to quantify the behavior of children when interacting with social partners and animals in naturalistic settings. The tool has been tested …

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Pg Publishing Co V. Newspaper Guild Of Pittsburgh Nov 2021

Pg Publishing Co V. Newspaper Guild Of Pittsburgh

2021 Decisions

USDC for the Western District of Pennsylvania

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Cell Therapy In Veterinary Medicine As A Proof-Of-Concept For Human Therapies: Perspectives From The North American Veterinary Regenerative Medicine Association, Boaz Arzi, Tracy L. Webb, Thomas G. Koch, Susan W. Volk, Dean H. Betts, Ashlee Watts, Laurie Goodrich, Michael S. Kallos, Amir Kol Nov 2021

Cell Therapy In Veterinary Medicine As A Proof-Of-Concept For Human Therapies: Perspectives From The North American Veterinary Regenerative Medicine Association, Boaz Arzi, Tracy L. Webb, Thomas G. Koch, Susan W. Volk, Dean H. Betts, Ashlee Watts, Laurie Goodrich, Michael S. Kallos, Amir Kol

Paediatrics Publications

In the past decade, the potential to translate scientific discoveries in the area of regenerative therapeutics in veterinary species to novel, effective human therapies has gained interest from the scientific and public domains. Translational research using a One Health approach provides a fundamental link between basic biomedical research and medical clinical practice, with the goal of developing strategies for curing or preventing disease and ameliorating pain and suffering in companion animals and humans alike. Veterinary clinical trials in client-owned companion animals affected with naturally occurring, spontaneous disease can inform human clinical trials and significantly improve their outcomes. Innovative cell therapies …

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Class Of 2021 | Jane Dreher Says Study In Berlin Gave Her New Perspective, Ohio University College Of Arts & Sciences Nov 2021

Class Of 2021 | Jane Dreher Says Study In Berlin Gave Her New Perspective, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

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Profiling Food Festivals By Type, Name And Descriptive Content: A Population Level Study, Muhammet Kesgin, Rajendran S. Murthy, Rick Lagiewski Nov 2021

Profiling Food Festivals By Type, Name And Descriptive Content: A Population Level Study, Muhammet Kesgin, Rajendran S. Murthy, Rick Lagiewski

Articles

Purpose: This research aims to classify and describe food festivals and examine the patterns in food festival naming and festival descriptions in online media. Design: This research represents the first population-level empirical examination of food festivals in the United States using a purpose-built dataset (N=2626). Methodology includes text mining to examine food festival communications. Findings: Food festival size varies across local and regional spheres within the country. Food festivals employ geographical (place-, destination-based) associations in their names. Food festivals’ descriptions and online communications showcase a welcoming environment predominantly emphasizing family-oriented and live entertainment experiences. Food festivals across the country show …

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Diversity, Equity And Inclusion In Human-Animal Interaction, Nira Grynheim Nov 2021

Diversity, Equity And Inclusion In Human-Animal Interaction, Nira Grynheim

Discovery Undergraduate Interdisciplinary Research Internship

No abstract provided.

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Diversity, Equity And Inclusion In Human-Animal Interaction, Nira N. Grynheim, Clare E. Jensen, Marguerite L. O'Haire Nov 2021

Diversity, Equity And Inclusion In Human-Animal Interaction, Nira N. Grynheim, Clare E. Jensen, Marguerite L. O'Haire

Discovery Undergraduate Interdisciplinary Research Internship

Human-Animal Interaction (HAI) is a growing field investigating the complex relationships humans have with animals. Human diversity in HAI, or lack thereof, may have a direct influence on the way HAI data is interpreted and presented. Previous research has studied how apparent disability, racial, sexual or other diversifying identities might affect how humans interact with the world and their pets. However, thus far, there has been little research published on how inequitable barriers towards underrepresented minorities (URM) might play a role in how HAI is studied, interpreted and presented. The present study investigated human diversity among leaders in the HAI …

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Tile Fish (Lopholatilus Villarii) Neurocranium, Maeya C. Yeatman, Sebastian K. Chan, David W. Kerstetter Nov 2021

Tile Fish (Lopholatilus Villarii) Neurocranium, Maeya C. Yeatman, Sebastian K. Chan, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium from 12 cm total length (TL) Tile fish (Lopholatilus villarii), collected from Foodtown on 10/22/2021 by Maeya Yeatman and Sebastian Chan

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Assessment Of Knowledge And Attitudes Of Medical Students On Tuberculosis, Arwa Abbas, Salam Mohammed Nov 2021

Assessment Of Knowledge And Attitudes Of Medical Students On Tuberculosis, Arwa Abbas, Salam Mohammed

Iraqi Postgraduate Medical Journal

BACKGROUND: Tuberculosis is one of the most common communicable diseases world wild and continues to be a major global health problem. It causes disease among millions of people each year, and, after HIV, it ranks as the second leading cause of death from an infectious disease worldwide. TB is a public health priority in Iraq. A report published by the World Health Organization highlighted ' the value of undergraduate tuberculosis training and outlined a systematic educational plan to ensure that students are provided with the necessary knowledge, skills, and attitudes essential to the effective management of tuberculosis. AIM OF STUDY: …

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Estimation Of Myeloperoxidase (Mpo), Oxidized Ldl And Glutathione (Gsh) In Patients With Acute Myocardial Infarction (Ami) In Three Iraqi Hospitals, Muataz Ali Al-Qazzaz, Mohammed Hamzah, Moayed Hamid Nov 2021

Estimation Of Myeloperoxidase (Mpo), Oxidized Ldl And Glutathione (Gsh) In Patients With Acute Myocardial Infarction (Ami) In Three Iraqi Hospitals, Muataz Ali Al-Qazzaz, Mohammed Hamzah, Moayed Hamid

Iraqi Postgraduate Medical Journal

BACKGROUND: Acute myocardial infarction (AMI) is a cardiovascular emergency that needs immediate diagnosis and treatment. Myeloperoxidase (MPO) an enzyme generated by active leukocytes, has been connected to atherosclerosis in a mechanistic way and earlier research has suggested that MPO could be employed as a diagnostic and analytical marker for AMI patients. Many cardiovascular disease ( CVD) events have been linked to oxidized-LDL (Ox-LDL) &Glutathione (GSH) . OBJECTIVE: Studies a new, rapidly rising, or cost-effective biomarker for the detection of AMI. PATIENTS AND METHODS: Eighty (80) patients & (40) control offered with chest pain presented to the Coronary Care Unit looking …

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Alda-1 Treatment And Prevention Of Pulmonary Disease, Narasaiah Kolliputi, Richard F. Lockey, Lakshmi Galam Nov 2021

Alda-1 Treatment And Prevention Of Pulmonary Disease, Narasaiah Kolliputi, Richard F. Lockey, Lakshmi Galam

USF Patents

Methods of treating or preventing allergic or pulmonary diseases characterized by endothelial dysfunction with Alda-1 are presented. Treatment of pulmonary endothelial cells subjected to hyperoxia with Alda-1 showed an increase in ALDH2 activity and expression. Treatment with Alda-1 also illustrated a decrease in oxidative stress, a decrease in reactive oxygen species (ROS), a decrease in apoptosis, a decrease in inflammation and an enhancement of mitochondrial membrane potential.

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Five Core Dimensions Of Purposeful System Transformation, Sandra Waddock, Steve Waddell Nov 2021

Five Core Dimensions Of Purposeful System Transformation, Sandra Waddock, Steve Waddell

Journal of Management for Global Sustainability

System transformation is fundamental, broad, deep, and multi-scalar change that involves a paradigm change, i.e., a radical shift, in five key interrelated and interactive dimensions that constitute the whole of a “complexly wicked” socio-ecological system. This paper discusses these dimensions and provides a rationale for focusing on them. The dimensions are purpose(s), perspectives, and performance metrics. They provide an umbrella for the other two, power(s) relationships and dynamics, and the combination of practices, policies, and processes (practices for short) that characterize how a given socio-ecological system operates.

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Snook Neurocranium Scan Mello & Glanzmann, Christopher F. Glanzmann, Madison A. Mello Nov 2021

Snook Neurocranium Scan Mello & Glanzmann, Christopher F. Glanzmann, Madison A. Mello

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

This file is a 3D scan of a Snook Neurocranium. Snook head provided by DR. Kerstetter and scan performed by Chris Glanzmann and Madison Mello. Medium detail scan with a simplification ratio of 50.

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Assessing Potentiation Of The (Α4)3(Β2)2 Nicotinic Acetylcholine Receptor By The Allosteric Agonist Cmpi, Farah Deba, Kemburli Munoz, Eloisa Peredia, Gustav Akk, Ayman K. Hamouda Nov 2021

Assessing Potentiation Of The (Α4)3(Β2)2 Nicotinic Acetylcholine Receptor By The Allosteric Agonist Cmpi, Farah Deba, Kemburli Munoz, Eloisa Peredia, Gustav Akk, Ayman K. Hamouda

Pharmacy Faculty Publications and Presentations

The extracellular domain of the nicotinic acetylcholine receptor isoforms formed by three α4 and two β2 subunits ((α4) 3(β2)2 nAChR) harbors two high-affinity “canonical” acetylcholine (ACh)-binding sites located in the two α4:β2 intersubunit interfaces and a low-affinity “noncanonical” AChbinding site located in the α4:α4 intersubunit interface. In this study, we used ACh, cytisine, and nicotine (which bind at both the α4:α4 and α4:β2 interfaces), TC-2559 (which binds at the α4:β2 but not at the α4:α4 interface), and 3-(2-chlorophenyl)-5- (5-methyl-1-(piperidin-4-yl)-1H-pyrrazol-4-yl)isoxazole (CMPI, which binds at the α4:α4 but not at the α4:β2 interface), to investigate the binding and gating properties of CMPI …

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The Seroprevalence Of Toxoplasma Gondii In Cats At The House Of Maternal Women With Toxoplasmosis In Badung, Indonesia, Made Subrata, Nyoman Mantik Astawa, Nyoman Tigeh Suryadi, Sang Gede Purnama, Kadek Karang Agustina, Ngakan Putu Anom Harjana, Made Damriyasa Nov 2021

The Seroprevalence Of Toxoplasma Gondii In Cats At The House Of Maternal Women With Toxoplasmosis In Badung, Indonesia, Made Subrata, Nyoman Mantik Astawa, Nyoman Tigeh Suryadi, Sang Gede Purnama, Kadek Karang Agustina, Ngakan Putu Anom Harjana, Made Damriyasa

Kesmas

Toxoplasmosis is a zoonotic disease caused by infection with the parasite called Toxoplasma gondii (T. gondii). The health and social impacts of the infectionare enormous, including miscarriage, hydrocephalus, blindness, and mental retardation. The occurrence of toxoplasmosis in maternal women cannot be se parated from cats around their houses. This study aimed to determine the seroprevalence of the parasite in cats found in the human carriers residences and identify the risk factors of toxoplasmosis in maternal women in Badung District, Bali Province, Indonesia. A total of 80 cat serum samples were obtained from two residential groups, 40 from the housing where …

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