Digital Commons Network^™

Epigenetic Clock And Methylation Studies In Elephants, Natalia A. Prado, Janine L. Brown, Joseph A. Zoller, Amin Haghani, Mingjia Yao, Lora R. Bagryanova, Michael G. Campana, Jesús E. Maldonado, Dennis L. Schmitt, For Complete List Of Authors, See Publisher's Website.

College of Agriculture

Age-associated DNA-methylation profiles have been used successfully to develop highly accurate biomarkers of age ("epigenetic clocks") in humans, mice, dogs, and other species. Here we present epigenetic clocks for African and Asian elephants. These clocks were developed using novel DNA methylation profiles of 140 elephant blood samples of known age, at loci that are highly conserved between mammalian species, using a custom Infinium array (HorvathMammalMethylChip40). We present epigenetic clocks for Asian elephants (Elephas maximus), African elephants (Loxodonta africana), and both elephant species combined. Two additional human-elephant clocks were constructed by combining human and elephant samples. Epigenome-wide association studies identified elephant …

Getting Started Creating Data Dictionaries: How To Create A Shareable Data Set, Erin M. Buchanan, Sarah E. Crain, Arielle L. Cunningham, Hannah R. Johnson, Hannah Stash, Marietta Papadatou-Pastou, Peder M. Isager, Rickard Carlsson, Balazs Aczel

College of Health and Human Services

As researchers embrace open and transparent data sharing, they will need to provide information about their data that effectively helps others understand their data sets’ contents. Without proper documentation, data stored in online repositories such as OSF will often be rendered unfindable and unreadable by other researchers and indexing search engines. Data dictionaries and codebooks provide a wealth of information about variables, data collection, and other important facets of a data set. This information, called metadata, provides key insights into how the data might be further used in research and facilitates search-engine indexing to reach a broader audience of interested …

‘A Hussy Who Rode On Horseback In Sexy Underwear In Front Of The Prisoners’: The Trials Of Buchenwald’S Ilse Koch, Mark A. Drumbl, Solange Mouthaan

Scholarly Articles

Ilse Koch’s trials for her role in atrocities at the Nazi Buchenwald concentration camp served as visual spectacles and primed her portrayal in media and public spaces. Koch’s conduct was credibly rumored to be one of frequent affairs, simultaneous lovers, and the sexual humiliation of prisoners. The gendered construction of her sexual identity played a distortive role in her intersections with law and with post-conflict Germany. Koch’s trials revealed two different dynamics. Koch’s actions were refracted through a patriarchal lens which spectacularized female violence and served as an optical space to (re)establish appropriate feminine mores. Feminist critiques of Koch’s trials …

Covid-19 And Export Restrictions: The Case For Free Trade, Jack Quirk

Loyola University Chicago International Law Review

No abstract provided.

Mechanical Behavior Of Bioceramic Materials: Case Study Of The Skeleton Of The Staghorn Coral, Acropora Cervicornis And The Tibia Of The Laboratory Mouse, Mus Musculus, Mahmoud Omer

Electronic Theses and Dissertations, 2020-2023

I studied two types of bioceramics: (A) the aragonite CaCO3 skeleton of the staghorn coral, Acropora cervicornis and (B) the hydroxyapatite Ca10(PO4)6(OH)2 bones of the laboratory mouse, Mus musculus. The research aimed to analyze coral deformation behavior and study dietary and estrogen depletions effects on bone strength. I compared the mechanical and structural properties of staghorn coral skeletons cleaned by chemical bleaching and biological processes. Optical microscopy and computed tomography (CT) revealed a sophisticated microstructure of non-homogenously distributed pores. Staghorn coral skeletons showed ''gracious" fracture, where the unique pore arrangements resisted catastrophic crack growth and prevented instantanous failure. Elastic moduli …

Critical Modding: A Design Framework For Exploring Representation In Games, Kenton Howard

Electronic Theses and Dissertations, 2020-2023

In this project, I created a framework for exploring problems with representations of marginalized characters in video games called "critical modding." The main goal of this project was to provide a method for addressing issues with portrayals of queer characters in video games through modification of a game's narrative and gameplay systems. I also created a video game prototype called Life in the Megapocalypse as a digital tool for engaging in critical modding. In addition, I created classroom assignments based on the game prototype aimed at helping people learn more about problems with portrayals of queer characters in games through …

Anxiety Explains Self-Differentiation: Implications For Bowenian Approaches To Marriage And Family Therapy, Reagan Thomas, John Shelley-Tremblay, Harvey Joanning

University Faculty and Staff Publications

This study examined the Bowenian construct of Self- Differentiation (SD), defined as the degree to which a person can think according to their personal beliefs while remaining emotionally connected to the family. This study examined the degree to which negative emotionality accounted for the relationship between SD and Relationship Satisfaction (RS). Emotional Cutoff (EC) emerged as the sole predictor of RS. When Trait Anxiety (TA) was entered into the model it mediated between EC and RS. We discuss the importance of treating anxiety of the individual in family therapy and that SD may best be understood when taking anxiety into …

Netchoice V. Moody, 11th Circuit Court Of Appeals

Historical and Topical Legal Documents

RCFP

The Motuporamines Act Through Rho1 And Rac To Control Actin Dynamics In Drosophila, Corey Seavey

Electronic Theses and Dissertations, 2020-2023

Given that most cancer patients die from metastatic disease, there is an urgent need to develop drugs that inhibit the spread of tumors. Studies show that the motuporamines activate the small GTPase RhoA to prevent cancer cell migration, but little is known about the mechanism of action of dihydromotuporamine C (Motu33) and its synthetic derivative Motu-(CH2)-33. In the present study, I investigated the biomolecular processes of these compounds in Drosophila by reducing the gene dose of positive and negative regulators of actin dynamics. Consistent with previous findings, reduced gene dose of Rho1 (the Drosophila RhoA ortholog) attenuates motuporamine activity confirming …

The Effect Of Polyelectrolyte Modification Of Ultrafiltration Membranes On Fouling Resistance And Rejection Of Contaminants Of Emerging Concern, Kunal Olimattel

Electronic Theses and Dissertations, 2020-2023

This research attempted to leverage the unique properties of poly (allylamine hydrochloride) (PAH)/poly (acrylic acid) (PAA) bilayer coatings to enhance antifouling and antimicrobial properties of a commercially available ultrafiltration (UF) membrane as well as the removal of PFOA and PFOS—the two CECs that most frequently represent the class of PFAS. The effects of selected water matrix components (humic acids [HA] and cations) on PFOA and PFOS removals were also investigated when using the functionalized membrane. PAH/PAA films were first deposited on the membrane using a fluidic layer by layer (LbL) technique and then crosslinked, followed by embedding of the silver …

Remediation Of Roadway Runoff Nutrients: Querying Sources Delivery Mechanism, Efficacy Of Stormwater Best Management Practices, And Stormwater Routing Through Karst Geology, Mohammad Shokri

Electronic Theses and Dissertations, 2020-2023

Stormwater road runoff is a widespread non-point source of contaminants such as nutrients, which endangers water bodies, especially in vulnerable karst areas such as Florida. While roadside vegetated filter strips (VFSs) and stormwater basins are generally accepted best management practices (BMPs) for stormwater management, uncertainties about VFS nutrient removal are reported and stormwater basins are concerned of facilitating contaminant transport. In this dissertation, the application and efficacy of engineered infiltration media was tested as a subgrade for the enhanced nutrient removal from roadway runoff. Results of field-scale laboratory testing indicated that a VFS with engineered biosorption activated media (BAM) outperformed …

Incongruous Surrealism Within Narrative Animated Film, Daniel Mccabe

Electronic Theses and Dissertations, 2020-2023

A pop music video is a form of media containing incongruous surrealistic imagery with a narrative structure supplied by song lyrics. The lyrics' presence allows filmmakers to digress from sequential imagery through introduction of nonlinear visual elements. I will analyze these surrealist film elements through several post-modern philosophies to better understand how this animated audio-visual synthesis resides in the larger world of art theory and its relationship to the popular music video. This analysis coincides with the practical and theoretical experimentation evident in the film companion to this thesis, Slapper the Cat: A Musical Cartoon. A long-form animated music video …

An Evaluation Of The Differences Between Perpetrators In Completed And Averted School Shootings, Ashley Winch

Electronic Theses and Dissertations, 2020-2023

School shootings have received a substantial amount of media attention and there have been a variety of explanations proposed as to their cause. While completed school shootings have been evaluated extensively, little research has been done into school shootings that have been averted, and even fewer studies have evaluated between group differences between completed and averted school shootings. The purpose of the present study was to assess the differences in completed and averted school shootings primarily with respect to the age of the perpetrators, the number of perpetrators, and participation in leakage warning behaviors. Additional demographic variables were assessed with …

Dietary Variation Of Social Elites Within A Late Horizon Cemetery (A.D. 1470-1532) At Túcume, Peru: Stable Carbon And Nitrogen Isotopic Analysis Of Huaca Las Abejas., Dylan Smith

Electronic Theses and Dissertations, 2020-2023

Food choices can create and maintain group membership, also distinguishing groups based on dietary preferences and the perceived social value of foods. The food behaviors of social elites within complex societies are often governed by differential access and cultural factors determining the menu within a regional ecology. This study employs bioarchaeological and stable isotopic analyses to investigate the evidence for dietary variation of social elites within the Late Horizon (A.D. 1470–1532) cemetery of Huaca Las Abejas at Túcume using stable nitrogen and carbon isotopes. Paired teeth (early life diet) and bones (later life diet) were sampled from 23 individuals to …

Characterization Of Clostridium Cochlearium As A Potential Probiotic For Obesity Management, Paba Edirisuriya

Wayne State University Dissertations

ABSTRACTCHARACTERIZATION OF CLOSTRIDIUM COCHLEARIUM AS A POTENTIAL PROBIOTIC FOR OBESITY MANAGEMENT

ByPABA EDIRISURIYA MAY 2021 Advisor: Dr. Kequan Zhou Major: Nutrition and food science Degree: Doctor of Philosophy Emerging evidence indicates that manipulation of gut microflora is a potential therapeutic approach for managing obesity. Probiotic effects on host weight reduction have repeatedly been revealed through previous studies. Clostridium cochlearium is a butyrate-producing, spore-forming bacteria that have been reported to present in the mammalian gut. Our simulated Invitro digestion model revealed that C. cochlearium could survive in the unfavorable conditions of the human gastrointestinal tract, including low pH (pH2), high bile …

Viral Factors Influencing Early Infection Events During Ex-Vivo Kshv Infection, Ramina Nabiee

Pharmaceutical Sciences (PhD) Dissertations

The enigma of Kaposi Sarcoma Herpes Virus infection, and its persistence despite a quarter century of research on the virus, has given rise to an immediate need for addressing fundamental questions about basic immunology and virology knowledge regarding this virus. Kaposi Sarcoma Herpes Virus (KSHV), also known as Human Herpesvirus 8 (HHV8), is the etiological agent of Kaposi Sarcoma (KS) and other lymphoproliferative cancers, such as Multicentric Castleman’s Disease (MCD), Primary Effusion Lymphoma (PEL), and a newly discovered rare disease called KSHV Inflammatory Cytokines Syndrome (KICS). Epidemic KS, also known as AIDS-KS, is the most common cancer in untreated HIV …

Investigating Lifespan And Legacy Health Effects Of Developmental Exposure To Environmental Toxicants, Danielle Meyer

Wayne State University Dissertations

The environmental presence of toxicants such as persistent organic pollutants, heavy metals, and contaminants of emerging concern is estimated to contribute to over 2 million deaths worldwide and health care costs ranging from ~3-9% of total global expenditures yearly. Many of the above toxicants are classified as endocrine-disrupting chemicals capable of interfering with endogenous hormonal function at environmentally relevant levels. Exposures during sensitive developmental windows can lead to reproductive, neurodevelopmental, and metabolic dysfunction that can last across the lifespan and/or be passed down to future generations. Such long-term effects remain to be well-understood; therefore, we modeled the effects of various …

A Survey Of Open Source Statistical Software (Osss) And Their Data Processing Functionalities, Gao Niu, Richard S. Segall, Zichen Zhao, Zhijian Wu

Faculty Publications

This paper discusses the definitions of open source software, free software and freeware, and the concept of big data. The authors then introduce R and Python as the two most popular open source statistical software (OSSS). Additional OSSS, such as JASP, PSPP, GRETL, SOFA Statistics, Octave, KNIME, and Scilab, are also introduced in this paper with function descriptions and modeling examples. They further discuss OSSS's capability in artificial intelligence application and modeling and Popular OSSS-based machine learning libraries and systems. The paper intends to provide a reference for readers to make proper selections of open source software when statistical analysis …

Cross-Cultural Validation Of A Revised Environmental Identity Scale, Susan Clayton, Sandor Czellar, Sonya Nartova-Bochaver, Jeffrey C. Skibins, Gabby Salazar, Yu-Chi Tseng, Boris Irkhin, Fredy Monge-Rodriguez

All Faculty Articles

The environmental identity (EID) scale, first published in 2003, was developed to measure individual differences in a stable sense of interdependence and connectedness with nature. Since then, it has been reliably correlated with measures of environmental behavior and concern. However, the original scale was developed based on U.S. college students, raising questions about its validity for other types of populations. This study revised the EID scale and tested it in five countries (four continents) with a total sample size of 1717 participants. Results support strong internal consistency across all locations. Importantly, EID was significantly correlated with behavior and with environmental …

Multivariate Analysis Of Mutant Wheat (Triticum Aestivum L.) Lines Under Drought Stress, Sadaf Zahra, Tayyaba Shaheen, Momina Hussain, Sana Zulfiqar, Mehboob-Ur Rahman

Turkish Journal of Agriculture and Forestry

Drought is a major threat to wheat production worldwide and development of drought-tolerant wheat genotypes may improve the production of this cereal crop in drought affected regions. In the present study, 24 mutant lines were developed by treating a wheat variety 'NN-Gandum-1(NN-1) with ethyl methane sulfonate (EMS). The M5, M6, and M7 generations were evaluated for quantitative traits under well irrigated and rainfed conditions. Furthermore, best performing mutants of M6 and M7 generations were examined for biochemical parameters. A substantial correlation was found among the quantitative traits (plant height, spike length, tillers per plant, number of spikelets per spike and …

Wake Up Or Get Woke: The Paradox Of America’S Diplomatic Export Of Hip Hop, Kalen M. Coleman

UC Law SF Communications and Entertainment Journal

No abstract provided.

Bs Wildlife, Fisheries, And Conservation, Wildlife 2021-22, Arkansas State University - Jonesboro

Bachelor of Science and Education

No abstract provided.

Bs Wildlife, Fisheries, And Conservation, Fisheries 2021-22, Arkansas State University - Jonesboro

Bachelor of Science and Education

No abstract provided.

2020 Annual Town Report Freemont, New Hampshire., Fremont Town Representatives

Fremont, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

An End To Cages In Europe?, Lewis Bollard

General – Farm Animal Issues

The European Commission has promised the biggest animal welfare legal reform in history — a ban on almost all cages and crates across the European Union (EU). If enacted, the ban would cover more than 340M caged hens, rabbits, pigs, and other animals. It could also set a new global standard for farm animal welfare. A major fight now looms. This Monday, several EU governments told the Commission that its proposal was too ambitious, and requested extensions and loopholes. Europe’s powerful farm lobby, Copa and Cogeca, is already lobbying to weaken the measure. This presents advocates with a unique opportunity: …

The Promise And Perils Of Insect Farming, Lewis Bollard

General – Farm Animal Issues

Insect farming is on the rise. Recent news stories have touted insects as “a six-legged solution to world hunger” (Time), “the next sustainable food revolution” (The Independent), and “the future of food” (NY Times). Insect protein is increasingly promoted alongside plant-based and cultivated meat as a green alternative to conventional meat.

Investors have noticed. In just the last year, French insect farming startups Ynsect and InnovaFeed raised $372M and $165M respectively, more than the whole sector had raised in all prior years combined. The UK’s first industrial-scale insect farm recently secured backing from retailer Tesco, startup incubator Y Combinator, and …

Care Working Conditions: The Ethics And Politics Of Social Reproductive Labor From Aristotle To Marxist Feminism, Andrew R. Van't Land

Theses and Dissertations--Philosophy

The spectre of an inescapably divided working class has haunted every generation of marxist theorists, including the latest wave of marxist feminists engaged in the research programme known as Social Reproduction Theory (SRT). In this dissertation, I will explain how Marx’s clear theoretical debt to Aristotle extends into the marxist feminist analysis of social reproductive labor and of the exploitation, class interests, and normative demands which condition such care workers. I will demonstrate how SRT can follow Marx’s own example in reading Aristotle, critically yet charitably, in order to resolve three problems. First, Aristotle’s original concept of use value (built …

Katie Beckett Program Update: A Joint Report To The Tennessee General Assembly [2021], Tenncare (Program), Tennessee. Department Of Intellectual And Developmental Disabilities

Katie Beckett Report to the General Assembly

This document contains the status of the Katie Beckett program, created in 2019 to assist Tennessee children with disabilities who are not eligible for Medicaid.

Annual Report, 2020-2021, Tennessee. Bureau Of Investigation

Annual Reports

This document is the annual report for the TBI during the fiscal year.

Understanding Successful Strategies Human Service First-Level Managers Utilize When Addressing Workplace Incivility, Mary Elizabeth Barlow

Walden Dissertations and Doctoral Studies

The social problem of workplace incivility is a well-researched issue that impacts employees, work groups, and organizations across the nation. The purpose of this study was to understand how first-level human service managers describe employee turnover in relation to workplace incivility and what first-level human service managers view as successful strategies they have used to address workplace incivility. The theoretical framework utilized for this study was incivility spiral theory, as described by Andersson and Pearson. The purpose of this generic qualitative study was to gain an understanding of successful strategies that first-level human service managers utilize when addressing workplace incivility …