Digital Commons Network^™

Developmental Stage-Specific Changes In Protein Synthesis Differentially Sensitize Hematopoietic Stem Cells And Erythroid Progenitors To Impaired Ribosome Biogenesis, Jeffrey A Magee, Robert A J Signer

Open Access Publications

Adult hematopoietic stem cell (HSC) self-renewal requires precise control of protein synthesis, but fetal and adult HSCs have distinct self-renewal mechanisms and lineage outputs. This raises the question of whether protein synthesis rates change with age. Here, we show that protein synthesis rates decline during HSC ontogeny, yet erythroid protein synthesis rates increase. A ribosomal mutation that impairs ribosome biogenesis (Rpl24

A Novel Dietary Multi-Strain Yeast Fraction Modulates Intestinal Toll-Like-Receptor Signalling And Mucosal Responses Of Rainbow Trout (Oncorhynchus Mykiss), Mark Rawling, Eric Leclercq, Andrew Foey, Mathieu Castex, Daniel Merrifield

School of Biological and Marine Sciences

No abstract provided.

Species Sensitivity Assessment Of Five Atlantic Scleractinian Coral Species To 1-Methylnaphthalene, Dorothy-Ellen A. Renegar, Nicholas Turner

Marine & Environmental Sciences Faculty Articles

Coral reefs are keystone coastal ecosystems that are at risk of exposure to petroleum from a range of sources, and are one of the highest valued natural resources for protection in Net Environmental Benefit Analysis (NEBA) in oil spill response. Previous research evaluating dissolved hydrocarbon impacts to corals reflected no clear characterization of sensitivity, representing an important knowledge gap in oil spill preparedness related to the potential impact of oil spills to the coral animal and its photosymbiont zooxanthellae. This research addresses this gap, using a standardized toxicity protocol to evaluate effects of a dissolved reference hydrocarbon on scleractinian corals. …

Genetic Murine Models Of Spinal Development And Degeneration Provide Valuable Insights Into Intervertebral Disc Pathobiology., J. Melrose, S. Tessier, M. V. Risbud

Department of Orthopaedic Surgery Faculty Papers

Disc degeneration and associated back and neck pain elicits a substantial burden on healthcare systems and the individuals affected, necessitating the development of novel therapeutic strategies. This goal can only be achieved by a better understanding of intervertebral disc development, homeostasis and pathogenesis. A number of genetic and in-bred murine models are reviewed to underscore the importance of the mouse as an animal model of choice for the assessment of intervertebral disc pathobiology. Appraisals of the differences between mouse and human musculoskeletal systems and proteoglycan structures are also included. A number of important target pathways and molecules have been identified, …

Stem Cell Factor In Combination With Granulocyte Colony-Stimulating Factor Protects The Brain From Capillary Thrombosis-Induced Ischemic Neuron Loss In A Mouse Model Of Cadasil, Suning Ping, Xuecheng Qiu, Maria E. Gonzalez-Toledo, Xiaoyun Liu, Li Ru Zhao

Faculty Publications

Cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CADASIL) is a Notch3 mutation-induced cerebral small vessel disease, leading to recurrent ischemic stroke and vascular dementia. There is currently no treatment that can stop or delay CADASIL progression. We have demonstrated the efficacy of treatment with combined stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) (SCF+G-CSF) in reducing cerebral small vessel thrombosis in a TgNotch3R90C mouse model of CADASIL. However, it remains unknown whether SCF+G-CSF treatment protects neurons from microvascular thrombosis-induced ischemic damage. Using bone marrow transplantation to track thrombosis, we observed that capillary thrombosis was widely distributed in …

Parenteral Fish-Oil Containing Lipid Emulsions Limit Initial Lipopolysaccharide-Induced Host Immune Responses In Preterm Pigs, William Yakah, David Ramiro-Cortijo, Pratibha Singh, Joanne Brown, Barbara Stoll, Madhulika Kulkarni, Berthe C Oosterloo, Doug Burrin, Krishna Rao Maddipati, Raina N Fichorova, Steven D Freedman, Camilia R Martin

Children’s Nutrition Research Center Staff Publications

Multicomponent lipid emulsions are available for critical care of preterm infants. We sought to determine the impact of different lipid emulsions on early priming of the host and its response to an acute stimulus. Pigs delivered 7d preterm (n = 59) were randomized to receive different lipid emulsions for 11 days: 100% soybean oil (SO), mixed oil emulsion (SO, medium chain olive oil and fish oil) including 15% fish oil (MO15), or 100% fish oil (FO100). On day 11, pigs received an 8-h continuous intravenous infusion of either lipopolysaccharide (LPS—lyophilized Escherichia coli) or saline. Plasma was collected for …

Dynamic Shifts In The Composition Of Resident And Recruited Macrophages Influence Tissue Remodeling In Nash, Sabine Daemen, Anastasiia Gainullina, Gowri Kalugotla, Li He, Mandy M Chan, Joseph W Beals, Kim H Liss, Samuel Klein, Ariel E Feldstein, Brian N Finck, Maxim N Artyomov, Joel D Schilling

Open Access Publications

Macrophage-mediated inflammation is critical in the pathogenesis of non-alcoholic steatohepatitis (NASH). Here, we describe that, with high-fat, high-sucrose-diet feeding, mature TIM4

Journal Of Water Sanitation And Hygiene For Development Use Of Single Particle Icp-Ms To Estimate Silver Nanoparticle Penetration Through Baby Porcine Mucosa, Ilaria Zanoni, Matteo Crosera, Elena Pavoni, Gianpiero Adami, Marcella Mauro, Anna Luisa Costa, Jamie Lead, Francesca Larese

Faculty Publications

Children are potentially exposed to products that contain nanoparticles (NPs). In particular, silver NPs are commonly present both in products used by and around children, primarily due to their antibacterial properties. However, very few data are available regarding the ability of silver NPs to penetrate through the oral mucosa in children. In the present work, we used baby porcine buccal mucosa mounted on vertical Franz diffusion cells, as an in vitro model to investigate penetration of silver NPs (19 ± 5 nm). Permeability experiments were performed using pristine physiologically-relevant saline solution in the receiver chamber and known concentrations of NPs …

Use Of Single Particle Icp-Ms To Estimate Silver Nanoparticle Penetration Through Baby Porcine Mucosa, Ilaria Zanoni, Matteo Crosera, Elena Pavoni, Gianpiero Adami, Marcella Mauro, Anna Luisa Costa, Jamie Lead, Francesca Larese Filon

Faculty Publications

Children are potentially exposed to products that contain nanoparticles (NPs). In particular, silver NPs are commonly present both in products used by and around children, primarily due to their antibacterial properties. However, very few data are available regarding the ability of silver NPs to penetrate through the oral mucosa in children. In the present work, we used baby porcine buccal mucosa mounted on vertical Franz diffusion cells, as an in vitro model to investigate penetration of silver NPs (19 ± 5 nm). Permeability experiments were performed using pristine physiologically-relevant saline solution in the receiver chamber and known concentrations of NPs …

January 12, 2021, Saint Mary's College Of California

The Collegian

No abstract provided.

Resistance To Aflatoxin Accumulation In Maize Mediated By Host-Induced Gene Silencing Of Aspergillus Flavus Alkaline Protease And O-Methyltransferase-A Genes, Olanike Omotola Omolehin

LSU Doctoral Dissertations

Aspergillus flavus is a soil-borne fungal pathogen that infects maize and produces aflatoxins. In the current study, portions of the alkaline protease (alk) and the O-methyl transferase (omtA) genes, which are key in A. flavus virulence and aflatoxin biosynthesis, respectively, were targeted for suppression through an RNAi (RNA interference) approach known as Host-Induced Gene Silencing (HIGS). Separate RNAi vectors were designed to carry regions of the alk and omtA gene fragments (Alk-RNAi and OmtA-RNAi) and introduced into B104 maize zygotic embryos. Eight and six transformation events were positive for the alk and omtA transgene, respectively. …

Coupled Ecological And Management Connectivity Across Administrative Boundaries In Undeveloped Landscapes, Clare E. Aslan, Mark W. Brunson, Benjamin A. Sikes, Rebecca S. Epanchin-Niell, Samuel Veloz, David M. Theobald, Brett G. Dickson

Environment and Society Faculty Publications

Human-induced ecological boundaries, or anthropogenic ecotones, may arise where administrative boundaries meet on undeveloped lands. Landscape-level ecological processes related to factors such as fire, invasive species, grazing, resource extraction, wildlife, and water may be affected due to unique management strategies adopted by each administrative unit. Over time, different management can result in discernible ecological differences (e.g., species composition or soil characteristics). Thus, fragmentation in the management landscape can correspond to ecological fragmentation. Different ecological patterns may emerge due to an increase in the number of management units in a region, or due to an increase in the number of different …

Edible Crickets (Orthoptera) Around The World: Distribution, Nutritional Value, And Other Benefits—A Review, Henlay J.O. Magara, Saliou Niassy, Monica A. Ayieko, Mukundi Mukundamago, James P. Egonyu, Chrysantus M. Tanga, Emily K. Kimathi, Jackton O. Ongere, Komi K.M. Fiaboe, Sylvain Hugel, Mary A. Orinda, Nanna Roos, Sunday Ekesi

All Peer-Reviewed Publications

Edible crickets are among the praised insects that are gaining recognition as human food and livestock feed with a potential of contributing to food security and reduction of malnutrition. Globally, the sustainable use of crickets as food or feed is undermined by lack of information on the number of the edible crickets, the country where they are consumed, and the developmental stages consumed. Furthermore, lack of data on their nutritional content and the potential risks to potential consumers limits their consumption or inclusion into other food sources. We reviewed published literature on edible cricket species, countries where they are consumed, …

Knowledge Network Embedding Of Transcriptomic Data From Spaceflown Mice Uncovers Signs And Symptoms Associated With Terrestrial Diseases, Amber M. Paul, Charlotte A. Nelson, Ana Uriarte Acuna, Ryan T. Scott, Atul J. Butte, Egle Cekanaviciute, Sergio E. Baranzini

Publications

There has long been an interest in understanding how the hazards from spaceflight may trigger or exacerbate human diseases. With the goal of advancing our knowledge on physiological changes during space travel, NASA GeneLab provides an open-source repository of multi-omics data from real and simulated spaceflight studies. Alone, this data enables identification of biological changes during spaceflight, but cannot infer how that may impact an astronaut at the phenotypic level. To bridge this gap, Scalable Precision Medicine Oriented Knowledge Engine (SPOKE), a heterogeneous knowledge graph connecting biological and clinical data from over 30 databases, was used in combination with GeneLab …

Single-Locus Species Delimitation And Ecological Niche Modeling Provide Insights Into The Evolution, Historical Distribution, And Taxonomy Of The Pacific Chorus Frogs, Robert C. Jadin, Sarah A. Orlofske, Tereza Jezkova, Christopher Blair

Publications and Research

The Pacific chorus frogs are a complex of three wide-ranging species (i.e. Hyliola hypochondriaca, Hyliola regilla, Hyliola sierra) whose current taxonomy remains unresolved. We conducted species delimitation analyses of these taxa using fragments of the cytochrome b and 12S–16S mtDNA genes to assess the species diversity. Importantly, we included samples from new locations throughout the range to better understand species distributions and identify potential contact zones among clades. Our analyses revealed three slightly parapatric but distinct species-level clades. Molecular dating revealed that these species began diverging in the Pleistocene c. 1.4 Mya with H. hypochondriaca and …

The Use Of Once Daily Milking Of Dairy Cows To Achieve Economic And Social Sustainability On New Zealand Dairy Farms, David A. Clark, Dawn E. Dalley

IGC Proceedings (1977-2023)

No abstract provided.

Effect Of Plant Patches On The Foraging Location Of Beef Cattle, Y. C. Zhou, Deli Wang, A. K. Xu, Z. F. Wang, H. Z. Yu

IGC Proceedings (1977-2023)

No abstract provided.

Lamb Fattening On Mediterranean‐Like Pastures In Chile Versus Olive Oil Cake‐Based Rations, C. Aguilar, R. Vera, R. Lira, J. Quenaya, Fernando Squella, H. Yutronic, P. Toro, P. Perez, I. Briones

IGC Proceedings (1977-2023)

No abstract provided.

Integration Of Small Holder Crop‐Forage‐Livestock Systems In South East Asia--An Eastern Indonesian Case Study, Neil D. Macleod, Shaun Lisson, Cam Mcdonald, Jeff P. Corfield, Rachmat Rahman, Ketut Puspadi

IGC Proceedings (1977-2023)

No abstract provided.

Increased Cave Use By Butterflies And Moths: A Response To Climate Warming?, Otto Moog, Erhard Christian, Rudolf Eis

International Journal of Speleology

Between 2015 and 2019, the list of Lepidoptera from “cave” habitats (i.e., proper caves, rock shelters and artificial subterranean structures) in Austria grew from 17 to 62 species, although the effort of data collection remained nearly constant from the late 1970s onwards. The newly recorded moths and butterflies were resting in caves during daytime in the the warm season, three species were also overwintering there. We observed Catocala elocata at 28 cave inspections, followed by Mormo maura (18), Catocala nupta (7), Peribatodes rhomboidaria, and Euplagia quadripunctaria (6). More than half of the species have been repeatedly observed in caves …

Sars-Cov-2 Pandemic Analytical Overview With Machine Learning Predictability, Anthony Tanaydin, Jingchen Liang, Daniel W. Engels

SMU Data Science Review

Understanding diagnostic tests and examining important features of novel coronavirus (COVID-19) infection are essential steps for controlling the current pandemic of 2020. In this paper, we study the relationship between clinical diagnosis and analytical features of patient blood panels from the US, Mexico, and Brazil. Our analysis confirms that among adults, the risk of severe illness from COVID-19 increases with pre-existing conditions such as diabetes and immunosuppression. Although more than eight months into pandemic, more data have become available to indicate that more young adults were getting infected. In addition, we expand on the definition of COVID-19 test and discuss …

Review Of Innumeracy In The Wild: Misunderstanding And Misusing Numbers By Ellen Peters, Gizem Karaali

Numeracy

Ellen Peters’s new book Innumeracy in the Wild: Misunderstanding and Misusing Numbers (Oxford University Press, 2020) is a whirlwind tour of psychological research on numeracy and its interactions with decision-making. The book is packed full of convincing arguments about the impact of numeracy and innumeracy on people's decisions and life outcomes, piles of supporting evidence and relevant references, and detailed expositions of multitudes of research results. Thus, it can serve the motivated reader well as a comprehensive literature review of psychologically oriented research on numeracy and decision-making.

Reflections On Innumeracy In The Wild, Ellen M. Peters

Numeracy

Peters, E. (2020). Innumeracy in the Wild: Misunderstanding and Misusing Numbers. (New York, NY: Oxford University Press) 315 pp. ISBN 978-0190861094

This piece briefly introduces and excerpts Innumeracy in the Wild: Misunderstanding and Misusing Numbers, written by Ellen Peters and published by Oxford University Press. Through a state-of-art review of the literature, the book explains how numeric ability supports the quality of the decisions people make and the life outcomes they experience. It presents three ways that people can be good or bad with numbers and how each of these numeric competencies matter to decision making.

Moral Rules In The Holy Quran That Affect Verbal Responses, Mahmoud Arif Edan

Midad AL-Adab Refereed Quarterly Journal

No abstract provided.

Usa V. Murray Rojas

2021 Decisions

USDC for the Middle District of Pennsylvania

John Henry Schlegel And The Muppet Show, Alfred S. Konefsky

Buffalo Law Review

No abstract provided.

Tuesday Afternoons With Schlegel, Barry Cushman

Buffalo Law Review

No abstract provided.

A Systematic Review Of The Nickel Content Of The Normal Human Prostate Gland, Vladimir Zaichick

Health Sciences

Introduction: The prostate gland is subject to various disorders. The etiology and pathogenesis of these diseases remain not well understood. Moreover, despite technological advancements, the differential diagnosis of prostate disorders has become progressively more complex and controversial. It was suggested that the nickel (Ni) level in prostatic tissue plays an important role in prostatic carcinogenesis and its measurement may be useful as a cancer biomarker. These suggestions promoted more detailed studies of the Ni content in the prostatic tissue of healthy subjects. Materials and methods: The present study is evaluated by systematic analysis of the published data for Ni content …

Affective Dependence: From Pathological Affectivity To Personality Disorders: Definitions, Clinical Contexts, Neurobiological Profiles And Clinical Treatments, Giulio Perrotta

Health Sciences

Starting from the general concept of affectivity, the present work focuses on the clinical, neurobiological, and dysfunctional aspects of the morbid condition, when dysfunction gradually becomes first an affective addiction and then a symptom of a psychopathological personality picture, thus suggesting a multidimensional treatment. From effective dependence to personality disorders, about the dynamics of human bonding, to the implications determined by the attachment theory, trying to demonstrate that the clinical category of affective dependence cannot be considered simply a form of behavioral dependence, as erroneously done in the last decade, but as a symptom of a psychopathological manifestation of personality, …

Orda Weekly Update, 2021.01.11, Office Of Research Development Administration

ORDA Weekly Update

No abstract provided.