Digital Commons Network^™

Three Cases Of Covid-19 Pneumonia That Responded To Icosapent Ethyl Supportive Treatment, Winston Suh, Ivan Urits, Omar Viswanath, Alan D. Kaye, Haresh Patel, Wade Hall, Jonathan P. Eskander

Ellmer School of Nursing Faculty Publications

BACKGROUND Icosapent ethyl, a form of eicosapentaenoic acid with anti-inflammatory activity, has been approved as an adjunctive treatment with statins in patients with hypertriglyceridemia. Icosapent ethyl is currently undergoing clinical trials to determine its anti-inflammatory effects in patients with coronavirus disease 2019 (COVID-19). This report describes 3 intensive care unit (ICU) patients with moderate to severe COVID-19 pneumonia treated with icosapent ethyl as part of their supportive care who had favorable outcomes.

CASE REPORT Case 1 was a 75-year-old man with a past medical history of hyperlipidemia, hypertension, type 2 diabetes mellitus, obesity, and benign prostatic hyperplasia. Case 2 was …

Stop The Bleed: Preparing Bystanders To Manage Life-Threatening Hemorrhage, Janice Hawkins, Heather Killion, Brandon Sparrer, Lynn Wiles

Ellmer School of Nursing Faculty Publications

[First paragraph] Do you know what to do if you encounter someone with life-threatening bleeding? Accidents can happen at any time, on the road, or in the workplace; It is important to know how to act quickly with the appropriate supplies needed to save a life.

A Poetical Version Of Nearly The Whole Of The Psalms Of David, Charles Wesley

Heritage Material

No abstract provided.

Problems Of The Sanctified, William Edward Shepard

Heritage Material

No abstract provided.

Comparison Of Rans Turbulence Models In Predicting Wake Development In A 2-Dimensional Actuator Disk Model, Chee Meng Pang, David Kennedy, Fergal O'Rourke Dr

Conference Papers

One of the most popular methodologies used to predict the wake of a tidal stream turbine (TST) is the RANS turbulence models coupled with the actuator disk method. This methodology has been widely adopted in the in the wind industry, since the mid-1990s, to predict wake development of wind turbines. Moreover, the reason for its popularity is its capability to give accurate results at an affordable computational cost, and the application of 2-dimensional actuator disk approach could further reduce the computational cost. In this paper, a number of RANS turbulence models represented by a porous disk were used to simulate …

How Can Higher Education Institutions Utilise Community Engagement To Support The Learning Of Enterprising Behaviour In Disadvantaged Communities?, Emma O'Brien

Doctoral

It is broadly agreed that entrepreneurship plays a crucial role in economic and societal development. Supporting entrepreneurship has become a global phenomenon, and governments and policy makers have paid increasing attention to it. Yet, despite such policy developments, the OCED (2019) has identified that several communities (including women, youth, seniors, unemployed and immigrants) remain disadvantaged and under-represented in entrepreneurial activity. Inclusive entrepreneurship policies recognise the significant economic and social contribution these communities could make if greater encouragement and appropriate support was offered. This study investigates the supportive role that Higher Education Institutions (HEIs) can play in strengthening social inclusion through …

Gender And Ethnicity: Are They Associated With Differential Outcomes Of A Biopsychosocial Social-Emotional Learning Program?, Ronnie I. Newman, Odikia Yim, David Shaenfield

Psychology Faculty Publications

Context: Social-emotional learning (SEL) program outcomes may be enhanced when programs take into account gender and ethnicity differences, yet few studies directly examine these variables. The limited literature further suggests improved outcomes accrue by integrating physiological techniques, such as yoga and meditation, directly into SEL curricula to reduce stress.

Aims: This study investigated the association between outcomes of a yogic breath-based biopsychosocial SEL intervention across gender and ethnicity.

Methods: Fifty-nine high school students were evaluated on 4 positive (self-esteem, identity formation, anger coping ability, planning, and concentration) and 3 negative SEL outcomes (impulsivity, distractibility, and endorsement of aggression). Using a …

Lighting For Sleep And Wellness With Changing Work Patterns: An Advisory Think-Piece, Kevin Kelly

Level 3

This advisory think-piece draws attention to the importance of using appropriate lighting in the context of home-working during Covid 19 workplace restrictions. In particular it emphasises the science underpinning the necessity for appropriate levels and types of lighting for good quality sleep, for well-being and the maintenance of circadian rhythms.

The Ambient Lighting Manifesto, Kevin Kelly, Peter Boyce, Kit Cuttle, Peter Raynham

Level 3

No abstract provided.

Using Internship Design To Shape Sustainable University-Industry Relationships:A Research Agenda?, Conor Horan

Level 3

This discursive article considers models and types of internships internationally and how particular models can be used as a strategic tool to shape effective university-industry partnerships. It argues why research into the nature, purpose and impact of internships in industry partnerships is urgently required.

The Regulatory Landscape For Atmps In The Eu And Us: A Comparison, Shada Warreth, Elaine Harris

Level 3

Every year, a small number medicinal products receive marketing authorisation or a product licence. However, in their wake several thousand drug candidates fall by the wayside. The discovery and development journey through to the approval and marketing stages of these successful candidates as we know it can take over 12 years and often much longer and costs approximately $2.6 billion (Sullivan, 2019). Prior to the regulatory authorities granting a marketing authorisation or product licence, the sponsor is required to provide a dossier that includes relevant administrative, quality, nonclinical and clinical data. In addition, both the EU and US regulatory bodies …

Exploring The Advantages Of Implementing Ich Q12, Susan Mcdonagh

Level 3

Global regulatory guidance for post approval changes to chemisty manufacturing controls (CMC) of commercial drug products lack harmonisation. Implementation of post-approval changes are slow and complex which can lead to supply issues of medicinal products with little or no continuous improvements to manufacturing processes being made. ICH Q12 Technical and Regulatory Considerations for Pharmaceutical Product Lifecycle Management was published in November 2019. This guideline provides a framework to facilitate the management of post-approval CMC changes in a more predictable and efficient manner. Tools and enablers in the guidline aim to enhance the transparency between the industry and the regulatory authorities …

Assessing If Patients Would Benefit From Electronic Patient Information Leaflets (Epils), Maria Gormley

Level 3

The importance of the patient information leaflet (PIL) is underlined by the fact it is the only mandatory information that patients in Europe are legislated to receive with their medicines. Issues with the PIL in its current paper format have been well documented and in recent years there has been a push to move from these paper leaflets provided in the medicine carton to the information being made available as an electronic PIL (ePIL). This paper explores the potential negative and positive consequences of ePILs and their impact on patients. In a survey of almost 600 people it was shown …

Effective Management Of Post-Approval Changes In The Pharmaceutical Quality System (Pqs):Through Enhanced Science And Risk-Based Approaches: Shelf-Life Extensions For Pharmaceutical Products, Kevin O'Donnell

Level 3

Post-approval changes are inevitable and necessary throughout the lifecycle of pharmaceutical products to implement new knowledge, maintain a state of control, and drive continual improvement. This One-Voice-of-Quality (1VQ) position paper is part of a series of industry case studies intended to demonstrate the standard application of the principles outlined in the publication “Effective Management of Post-Approval Changes in the Pharmaceutical Quality System (PQS) - Through Enhanced Science and Risk-Based Approaches Industry; One-Voiceof-Quality (1VQ) Solutions” in PDA Journal of Pharmaceutical Science and Technology, 2020 [1]. Furthermore, this 1VQ position paper provides a practical application of the concepts described in ICH Q9, …

Quality Risk Management: Seeking The Diamonds: Making The Case For Improved Formality In Qrm Decision-Making, Valerie Mulholland, Anne Greene

Level 3

In November 2020, a newly formed working group of the ICH (International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use) published a concept paper [1] outlining the considerations for an update to ICH Q9: Quality Risk Management [2]. In the concept paper, the expert group identified four areas for improvement with respect to the current application of Quality Risk Management (QRM). One of the areas identified as problematic was a ‘lack of clarity in risk-based decision making’. The paper described a ‘lack of clarity on what good risk-based decisionmaking means’. This paper looks at risk-based decision-making and, …

Qrm: A Case For Convergence: A Reminder That Quality Risk Management Must Work With Other Risk Management Systems, Valerie Mulholland

Level 3

This article reflects that Quality Risk Management (QRM) is operating in a different technological environment since the ICH Q9: Quality Risk Management [1] guidance was first published in 2005. This paper explores the array of risk management systems that influence operations in a typical modern high-tech manufacturing facility. These ‘other’ risk management systems, either directly or indirectly, inform both the risk assessments and the control strategies developed by QRM. Convergence is another word for coming together. In order to assure that QRM can fully align and converge within operations, it must also ensure that it can align with these allied …

Pediatric Immunization Practices In Nephrotic Syndrome: An Assessment Of Provider And Parental Knowledge, Cheryl L Tran, David T Selewski, Gia J Oh, Jonathan P Troost, Susan F Massengill, Samhar I Al-Akash, Shefali Mahesh, Rasheda Amin, Isa F Ashoor, Rahul Chanchlani, Mahmoud Kallash, Robert P Woroniecki, Debbie S Gipson

Faculty, Staff and Student Publications

Background: Children with nephrotic syndrome (NS) are at high risk for vaccine-preventable infections due to the immunological effects from the disease and concurrent treatment with immunosuppressive medications. Immunizations in these patients may be deferred due to their immunosuppressive treatment which may increase the risk for vaccine-preventable infections. Immunization practices in children with NS continue to vary among pediatric nephrologists. This raises the question of whether children with NS are receiving the recommended vaccinations at appropriate times. Therefore, it is critical to understand the practices and patient education provided by physicians to patients on the topic of vaccinations.

Methods: After informed …

All Pay Quality-Bids In Score Procurement Auctions, Dan Kovenock, Jingfeng Lu

ESI Working Papers

In this paper, we study score procurement auctions with all-pay quality bids. A supplier’s score is the difference between his quality and price bids. The supplier with the highest score wins and gets paid his own price bid. The procurer’s payoff is the difference between the winner’s quality and the procurer’s payments to the suppliers. Equilibrium quality and price bids are solved without first obtaining the corresponding equilibrium scores. We find that quality bids, the suppliers’ payoffs and the procurer’s payoff do not depend on whether price bids are made contingent on quality bids. Compared to a benchmark of winner-pay …

Reconsidering Rational Expectations And The Aggregation Of Diverse Information In Laboratory Security Markets, Brice Corgnet, Cary Deck, Mark Desantis, Kyle Hampton, Erik O. Kimbrough

ESI Working Papers

The ability of markets to aggregate dispersed information is a cornerstone of economics and finance. In a seminal experiment, Plott and Sunder (1988) offer support for the rational expectations hypothesis. However, recent laboratory experiments have called into question the robustness of those initial results. In this paper, we offer the first attempt to directly replicate key findings of the original study. Failing to replicate their results, the post-study probability that market performance is better described by rational expectations than the prior information (Walrasian) model is low. Given this result, we introduce a new treatment that implements a market structure consistent …

Natural Lead-In Approaches To Response-Adaptive Allocation In Clinical Trials, Erin E. Donahue

Theses and Dissertations

Response-adaptive (RA) allocation designs can be implemented in clinical trials to skew the allocation of incoming subjects toward the better performing treatment group based on the previously accrued subjects' responses. These designs alleviate potential ethical concerns of equally allocating subjects in a trial when one treatment arm is inferior. The RA design can be generalized to include covariate information in the covariate-adjusted response-adaptive (CARA) design, which aims to maximize treatment successes conditional on a set of patient characteristics. While RA and CARA designs can improve the treatment of patients, they have unstable estimators and increased variability in early stages of …

Bridging The Digital Divide: A Risk-Based “Telehealth Needs” Scoring Model For Patient Outcome Prediction, Cindy Ann Crump

Theses and Dissertations

The purpose of the research was to develop a predictive model of the effect of patient characteristics on outcomes and resource utilization in telehealth interventions for chronic disease management. Clinical studies have shown high variability in telehealth across settings and populations. The central hypothesis of this study was that patient characteristics, including disease type, illness severity, demographic information, and socio-technical preferences play a role in determining telehealth intervention outcomes. A non-experimental, retrospective study evaluated the feasibility of creating a Telehealth Needs score using Medicare and Medicaid claims data from 2016 to 2017. Claims were summarized into de-identified cases to train …

Epigenetic Alterations At Synaptic Plasticity Genes In A Genetically Heterogeneous Rat Model Of Neuropsychiatric Disorders, Doan M. On

Theses and Dissertations

Sensorimotor gating impairments are observed across a range of neuropsychiatric conditions. The prepulse inhibition of the acoustic startle response (PPI) is a validated measure of sensorimotor gating. Genetic and pharmacological manipulations in rodents have shown PPI is regulated by specific brain monoaminergic systems. Using genetically heterogeneous NIH-HS rats, we stratified individuals by %PPI. In low PPI animals, we observed elevated mRNA levels of certain neurotransmitter receptors, including metabotropic glutamate receptor Grm2, dopamine receptors Drd1 and Drd2, serotonin receptors Htr1a and Htr2a, and scaffolding protein Homer1, in the frontal cortex (FC) and striatum (STR). We found Drd2 …

From Bedside To Bench: Use Of Patient-Derived Xenograft Models To Develop Novel Therapeutic Strategies For Triple-Negative Breast Cancer, Tia H. Turner

Theses and Dissertations

Triple-negative breast cancer (TNBC) is a clinically aggressive disease that is associated with bleak outcomes due to its metastatic propensity, frequent failure to respond to chemotherapy, and lack of alternative treatment options. Despite decades of major translational research efforts, there has been very little success thus far in the development of effective targeted therapies for this disease. It is imperative to develop novel therapeutic strategies to improve patient outcomes, as well as minimize the toxicity associated with standard-of-care chemotherapeutics. Given that metastatic disease accounts for the vast majority of TNBC-related deaths, a better understanding of therapeutic responses within common sites …

A Longitudinal Study Of The Influence Of A Stem Career Planning Course And Perceived Stress On Career Search Self-Efficacy And Retention In Engineering Undergraduate Students, Autumn Randell

Theses and Dissertations

This study investigated a) the influence of a STEM career planning course on undergraduate engineering students’ career search self-efficacy, b) the influence of perceived stress on building students’ career search self-efficacy, and c) the relationship career search self-efficacy had in predicting students’ odds of persistence in an engineering major. The researcher analyzed students’ week 1, week 6, and week 14 scores of career search self-efficacy and perceived stress. Data were collected from the Spring 2019 and Fall 2019 cohorts of a STEM career planning. As a result, the analysis included (N = 286) undergraduate engineering students. Repeated measures multilevel …

The Role Of Patient Room-Type, Interruptions, And Intrapersonal Resources In Nurse Performance And Well-Being, Jennifer Early

Theses and Dissertations

Interruptions create a complex challenge in health care. Because some interruptions are necessary in health care, they cannot be completely eliminated. Thus, their effects must be appropriately mitigated. To better understand predictors and consequences of interruptions, as well as factors that may mitigate their negative effects, I employed Job Demands-Resources (JD-R) theory, supplemented by additional constructs from organizational behavior and psychology to develop a model of predictors and mitigators of interruptions. Twenty registered nurses providing care on a progressive acute care unit with single- and double-occupancy patient rooms volunteered to participate in this study. The study incorporated nurse-level questionnaires, event-level …

The Effect Of Intermittent Theta Burst Stimulation On Biceps Corticomotor Excitability In Non-Impaired Individuals And Individuals With Tetraplegia, Blaize Majdic

Theses and Dissertations

Neuromodulation of the primary motor cortex (M1) in pair with physical therapy may be a promising method for improving motor outcomes after spinal cord injury (SCI). Increased excitability of the corticospinal motor pathways (i.e. corticomotor excitability) has shown to be associated with improved motor learning and skill acquisition. Intermittent theta burst stimulation (iTBS) is a form of non-invasive brain stimulation which can increase corticomotor excitability, as measured by an increase in the amplitude of motor evoked potentials (MEPs). However, the ability for iTBS to increase the corticomotor excitability of proximal muscles such as the biceps, and muscles affected by spinal …

Understanding The Contributions Of Discrepant Parent-Adolescent Views Of Parenting Practices And Peer Deviance To Adolescent Problem Behavior: A Cross-Lagged Polynomial Regression Approach, Mallory Stephenson

Theses and Dissertations

The present study used autoregressive cross-lagged models to examine the processes through which peer deviance and discrepant parent-adolescent views of monitoring-related communication, involvement, and positive parenting influence one another and contribute to physical and relational aggression, substance use, and delinquency. Participants included 535 adolescents (64% male) who were identified as prone to aggression and socially influential by their sixth-grade teachers during the 2001-2002 and 2002-2003 school years; participants self-identified as African American (69%), Hispanic (14%), White (9%), Multiracial (5%), or another race (3%). Contrary to expectations, parent-adolescent reporting discrepancies were not related to peer deviance, physical aggression, substance use, and …

Exploring The Use Of Pulsed Erbium Lasers To Retrieve A Zirconia Crown From A Zirconia Implant Abutment, Ahmed Elkharashi

Theses and Dissertations

Removal of zirconia crowns, commonly used as cement-retained implant fixed restorations, can be challenging. Conventional methods of crown removal are time consuming and often leave irreparable damage to the crown, which can be costly to patients and practitioners. This research explored the use of two different types of pulsed erbium lasers, erbium-doped yttrium aluminum garnet laser (Er:YAG) and erbium, chromium-doped yttrium, scandium, gallium and garnet (Er,Cr:YSGG), as non-invasive tools to retrieve cemented zirconia crowns from zirconia implant abutments. Times needed to remove the crowns were recorded and analyzed using ANOVA (��=0.05). No statistical differences between the debond times of each …

Effects Of Active Reminders And Motivational Techniques On Oral Hygiene And Gingival Health In Orthodontic Patients: A Randomized Clinical Trial, Jennifer Shim

Theses and Dissertations

Purpose: To compare repeated oral hygiene instructions and motivation to text message reminders in improving oral hygiene compliance

Methods: For this prospective, randomized controlled clinical trial, 60 patients were assigned to one of four groups. Group 1 served as a control. Group 2 received weekly text message for oral hygiene. Group 3 received in-person oral hygiene instructions at each visit. Group 4 received both text messages and in person oral hygiene instructions. Oral hygiene was measured with Bleeding Index (BI), Modified Gingival Index (MGI), and Plaque Index (PI). Baseline measurements were obtained at the day of bonding (T0) and then …

Generation Of Warm Dense Plasma On Solar Panel Infrastructure In Exo-Atmospheric Conditions, Harrison C. Wenzel

Theses and Dissertations

The use of a weaponized thermo-nuclear device in exo-atmospheric conditions would be of great impact on the material integrity of orbiting satellite infrastructure. Particular damage would occur to the multi-layered, solar cell components of such satellites. The rapid absorption of X-ray radiation originating from a nuclear blast into these layers occurs over a picosecond time scale and leads to the generation of Warm Dense Plasma (WDP). While incredibly difficult and costly to replicate in a laboratory setting, a collection of computational techniques and software libraries may be utilized to simulate the intricate atomic and subatomic physics characteristics of such an …