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Liposomal Encapsulation Of Silver Nanoparticles (Agnp) Improved Nanoparticle Uptake And Induced Redox Imbalance To Activate Caspase-Dependent Apoptosis, Azeez O. Yusef, Alan Casey

Articles

Macrophages play a crucial role in several diseases’ development and progression, such as in cancer and arthritis through ROS generation and infammation. This makes macrophages a therapeutic target in these diseases. While silver nanoparticles (AgNP) have been widely used as an antibacterial and investigated as anticancer, its potential against macrophages may be limited due to its inherent oxidative mechanism. Here we encapsulated AgNP in a dipalmitoyl-phosphatidyl choline (DPPC) liposome (forming Lipo-AgNP) to suppress AgNP-induced ROS and enhance its cytotoxicity against THP1-diferentiated macrophages (TDM). Our fndings showed that while Lipo-AgNP had signifcantly more of a cytotoxic efect on TDMs (p< 0.01), it also signifcantly suppressed AgNP induced ROS generation and unexpectedly suppressed reduced glutathione (GSH) levels (p< 0.05) resulting in a redox imbalance in comparison to the unexposed control TDMs. Lipo-AgNP was also found to cause an increase DNA damage through H2AX histone phosphorylation and inhibition of Bcl-2 protein expression. This increased the Bax/Bcl2 ratio causing possible release of cytochrome C and subsequent caspase 3/7-dependent apoptosis. It was found that the diference between the mechanism of AgNP and Lipo-AgNP cytotoxicity may have been through the signifcantly increased Lipo-AgNP uptake by the TDMs as early as 30 min post-exposure (p< 0.05), changing the nanoparticle pharmacokinetic. In conclusion, the improved uptake of AgNP within the liposome caused ROS-independent caspase activation induced by Lipo-AgNP and this was facilitated by increased DNA damage, the induced redox imbalance and an increased Bax/Bcl-2 ratio.

53(1) Front Matter

UBC Law Review

No abstract provided.

Imperfect Evidence And Uncertain Justice: An Exploratory Study Of Access To Justice Issues In Canada's Asylum System

UBC Law Review

No abstract provided.

Thinly Construing The Nature Of The Act Legally Consented To: The Corrosive Impact Of R V Hutchinson On The Law Of Consent

UBC Law Review

No abstract provided.

Experts On Trial: Unearthing Bias In Scientific Evidence

UBC Law Review

No abstract provided.

Full Disclosure: Family Violence And Legal Ethics

UBC Law Review

No abstract provided.

Deliberative Constitutional Referendums In Deeply Divided Societies Special Section: Deliberative Democracy, Peace Referendums, And Constitutional Settlement

UBC Law Review

No abstract provided.

The Effects Of Thyme Oil And Black Cumin Oil In Broiler Feeding On Growth Performance, Intestinal Histomorphology, And Cecal Volatile Fatty Acids, Özlem Durna Aydin, Gülteki̇n Yildiz

Turkish Journal of Veterinary & Animal Sciences

The aim of the study was to investigate the effects of thyme oil and black cumin oil that are added to broiler rations at certain ratios, on performance (body weight, body weight gain, feed intake, feed conversion ratio, mortality, European Production Efficiency Factor (EPEF), histomorphological parameters of jejunum and ileum, and cecal short-chain fatty acid (SCFA) concentrations. In the study, 216 male chicks (Ross 308) were randomly divided into 4 groups of 54 chicks each. Each group was divided into 9 subgroups of 6 chicks. The chicks were fed with corn, soya bean, and full-fat soybean-based rations for 42 days. …

Herbal Feed Additives Containing Tannins: Impact On In Vitro Fermentation And Methanemitigation From Total Mixed Ration, Manju Wadhwa, Prabh Kaur Sidhu, Mohinder Pal Singh Bakshi

Turkish Journal of Veterinary & Animal Sciences

Total mixed ration (TMR) containing roughage and concentrate mixture in a 65: 35 ratio on dry matter (DM) basis was supplemented with herbal feed additives [(HFAs); Acacia catechu (Katha), Areca catechu (Supari), and Acacia nilotica (Babul)] at 0-4% on DM basis to assess their impact on fermentation pattern and methane production by using in vitro gas production technique. Areca catechu had the highest (P < 0.01) concentration of condensed tannins (CTs), saponins, and vitamin C as compared to other HFAs. The net gas production (NGP), digestibility of NDF and true OM, and ME availability, partitioning factor (PF), volatile fatty acids (VFAs), and microbial biomass production were higher (P < 0.01) at 24 h as compared to t-half incubation, irrespective of type and level of HFAs supplemented. Acacia nilotica had an edge over Acacia catechu with respect to digestibility of nutrients and ME availability. VFAs production and efficiency of rumen fermentation was the highest from the Areca catechu-supplemented TMR. Irrespective of type of HFAs and incubation period, the digestibility of NDF and that of true OM were highest (P < 0.01) at the 1% level of supplementation, but depressed thereafter. Amongst HFAs-supplemented groups, VFA production and fermentation efficiency were highest at the 2% level. The results conclusively revealed that supplementing Areca catechu and Acacia nilotica at 2% of TMR (DM basis) inhibited the methane production, without affecting the fermentation pattern.

Changes In Serum Biochemical And Lipid Profile, And Fatty Acid Composition Of Breast Meat Of Broiler Chickens Fed Supplemental Grape Seed Extract, Özlem Karadağoğlu, Tarkan Şahi̇n, Mükremi̇n Ölmez, Akin Yakan, Bülent Özsoy

Turkish Journal of Veterinary & Animal Sciences

A study was conducted to evaluate the changes in serum biochemical and lipid profile, and fatty acid composition of breast meat of broiler chickens fed supplemental grape seed extract (GSE). A total of 240 1-day-old male broiler chickens were randomly allocated to 4 groups, each consisting of 4 replicate pens having 15 birds/replicate pen. One group served as control group fed basal diets and other groups received 100, 200, and 400 ppm GSE supplemented to the basal diets. Liver weight was greater in broilers fed 200 ppm GSE compared to the other groups (P = 0.004, L = 0.024, C …

Sheep Welfare During Transport And Slaughter In Bulgaria - Impact Of Welfare On Slaughter Carcass And Meat Quality: A Review, Nikolay Todorov Ivanov

Turkish Journal of Veterinary & Animal Sciences

The present work aimed to review the state of sheep welfare in Bulgaria during transportation and slaughter and to evaluate its relationship with slaughter carcass and meat quality. Over the last few years, animal welfare has become increasingly important. Normative documents related to welfare during rearing, transport, and slaughter of animals have been developed and promulgated. A major percentage of these animals are reared for meat production, but attempts to minimize stress and pain during transport and slaughter should be made. Stress reduction and pain control improve animal welfare and also impact carcass and meat quality. This overview demonstrates that …

Salivary Cortisol Levels In Horses And Their Junior Riders During Show Jumping, Katarzyna Strzelec, Slawomir Pietrzak, Tomasz Próchniak, Iwona Janczarek, Anna Cywinska, Andrzej Bereznowski

Turkish Journal of Veterinary & Animal Sciences

The group of 22 warm-blooded half-breed horses (6 stallions, 6 mares, and 10 geldings) and their riders (12 women and 10 men) who ended jumping competition for juniors, were selected for a study. The horses were aged from 7 to 17 years, while the riders were 15 to 18 years old. The saliva samples were collected before and after each jumping round. The cortisol concentration was determined by using an immunoassay method. The following factors were considered: horses' sex, age, and breeds, riders' sex and age as well. In riders, significant correlation was found in the group of younger juniors …

The Effects Of Supplemental Niacin And Methionine On Serum Glucose, Betahydroxybutyric Acid, And Non-Esterified Fatty Acid Levels During Late Gestation And Early Postpartum Period In Damascus Dairy Goat, Mustafa Kemal Saribay, Ayşe Merve Köse, Bülent Özsoy, Umair Ahsan, Ece Koldaş Ürer, Serkan İrfan Köse, Gökhan Doğruer

Turkish Journal of Veterinary & Animal Sciences

The objective of this study was to assess the changes in serum glucose, beta-hydroxybutyric acid (ß-HBA), and nonesterified fatty acid (NEFA) levels in Damascus dairy goats fed niacin (Nia) and methionine (Met) during late gestation and early postpartum period. A total of 75 dairy goats at 105th day of gestation were divided into 3 groups as control (no supplementation), Nia (20 g/kg Nia), and Met (2.5 g/kg Met) groups. The dietary treatments continued until parturition. Dairy goats fed dietary Nia had greater serum glucose levels on day 125 of gestation compared to the other dietary treatments (P < 0.05). On day 135 of pregnancy, serum glucose levels were higher in Met group than control group (P < 0.05). Serum ß-HBA levels decreased on days 135 and 145 in dairy goats fed Nia than those in control group. Dietary Nia and Met lowered serum ß-HBA levels on day 10 postpartum compared to control group (P < 0.05). Serum NEFA levels decreased (P < 0.05) on days 135 and 145 in dairy goats fed Nia supplemented ration than those in control group. Serum NEFA levels d 10 postpartum were different among the groups (P < 0.05). In conclusion, dietary Nia and Met supplementation improved serum glucose levels on day 125 of gestation while decreasing ß-HBA and NEFA levels during late gestation and early postpartum period in Damascus dairy goats under the conditions of present study.

Evaluation Of Gait Character Of Akbaş And Kangal Shepherd Dogs By Using Pressuresensitive Walkway, Ozan Gündemi̇r, Hasan Alpak, Di̇lek Olğun Erdi̇kmen, Di̇dar Aydin Kaya

Turkish Journal of Veterinary & Animal Sciences

In this study, it was aimed to evaluate which walking analysis data may be obtained for Kangal and Akbaş shepherd dogs using a pressure-sensitive walkway (PSW) and which of these data may be used in the fields of veterinary anatomy, orthopedics, and neurology. Center of pressure (COP) analysis results of 46 dogs were examined. Distance type gait parameters of dogs were measured and their foot zone analysis values were recorded. It was observed that the pressure values applied by forelimb steps on the ground were higher compared to the pressure applied by hindlimb steps. The highest peak vertical force (PVF) …

Assessment Of Changes In The Saliva Cortisol Level Of Horses During Different Waysin Recreational Exploitation, Boguslawa Dlugosz, Tomasz Próchniak, Monika Stefaniuk-Szmukier, Marta Basiaga, Jaroslaw Luszczynski, Magdalena Pieszka

Turkish Journal of Veterinary & Animal Sciences

The aim of this study was to evaluate the saliva cortisol levelsof recreational horses dependent on the type of horse activity. A total of 68 horses were included in the experiment and divided into groups according to recreational activity, type of horse, age, term of saliva collection, and sex. Saliva samples were obtained from each horse at 3 measurement points: in the morning (6 a.m.), in the evening (6 p.m.), and immediately after work. The overall analysis shows that the term of sample collection, recreational activity, and age influence cortisol concentration. The diurnal concentration of saliva cortisol does not differ …

Evaluation Of Larval Culture And Conventional Pcr Methods For The Detection Ofstrongylus Vulgaris In Equines Of Iran, Alireza Alborzi, Sara Larki, Abbas Zeinali

Turkish Journal of Veterinary & Animal Sciences

Strongylus vulgaris (S. vulgaris) is known as the equin's most pathogenic nematode due to the extraintestinal migration in mesenteric arterial vessels. Since a few kinds of S. vulgaris can threat the animals' health and working efficiency, high precision and early detection of strongylid nematodes is essential. Traditionally, the larval coproculture method was used frequently for identification of strongylid species. The technique of larval culture is costly, time consuming, and does not have sufficient accuracy and reliability. Here, we critically evaluated the polymerase chain reaction (PCR) with larval culture methods for the detection of S. vulgaris eggs in fecal samples. To …

Extended Spectrum Beta-Lactamase (Esßl), Ampc And Carbapenemase Activities Andcolistin Resistance Of Salmonella Spp. Isolated From Food Poisoning Cases In Turkey, Si̇bel Kizil

Turkish Journal of Veterinary & Animal Sciences

This study aims at detecting antimicrobial resistance properties including extended spectrum beta-lactamase (ESBL), AmpC, carbapenemase activities (imipenem, meropenem and ertapenem), and colistin resistance of isolated and serotyped Salmonella spp. strains from various foods (mostly chicken and chicken products) that cause food poisoning. The ISO 6579-3 (Kaufmann-White scheme) method was used for serotyping of Salmonella spp. and for detection of antimicrobial resistance with Minimum Inhibitory Concentration (MIC) as reported by EURL-AR. Inoculums were separated into EUVSEC and EUVSEC2 panels using the Sensititre AIM Automated Inoculation Delivery System. The results were monitored in a semiautomatic vision reader and evaluated according to EUCAST. …

Effects Of Activated Charcoal And Zeolite On Serum Lipopolysaccharides And Someinflammatory Biomarkers Levels In Experimentally Induced Subacute Ruminal Acidosis Inlambs, Ali Abbas Nikvand, Mohammad Nouri, Mohammad Razi Jalali, Mohammad Reza Teimory Azadbakht

Turkish Journal of Veterinary & Animal Sciences

Bacterial lipopolysaccharides (LPS) play a key role in the pathogenesis of subacute ruminal acidosis (SARA). Limited attempts have been made to inhibit LPS absorption during SARA. Therefore, this study aimed to evaluate the impacts of oral usage of activated charcoal and zeolite on serum LPS and acute phase proteins (APPs) levels in lambs with SARA. Fifteen lambs were randomly assigned to 3 groups, each containing 5 lambs: control, activated charcoal, and zeolite. In all groups, SARA was induced for 7 days through increasing the crushed corn ration to 52.8% and reducing the rumen pH to the range of 5.7-5.6. In …

Biosecurity Levels Of Livestock Enterprises In Turkey And Factors Affecting These Levels, Mehmet Feri̇t Can, Nuri̇ Altuğ, Ferhan Kaygisiz

Turkish Journal of Veterinary & Animal Sciences

Biosecurity (BS) is a multidimensional preventive medicine approach that has health, technical, and financial aspects. The purpose of this study was to determine the differences of the BS scores belonging to the livestock enterprises depending on the geographical region and breeding types and to predict the socioeconomic factors having an impact over the BS level. The study was conducted with 517 breeders who live in 7 different regions of Turkey. The results have revealed that the enterprises performing "beef cattle fattening and dairy cattle breeding together" have higher BS scores than the enterprises in the other breeding category (P < 0.01). The differences between the technical and financial scores according to geographical regions were statistically significant (P < 0.01). The regions categorized as "wes" have the highest score and "south" have the lowest score. It was determined that as the "educational level of the breeder" and "enterprise scale" increased, the BS score significantly went up. The regression model was found significant as a whole (P < 0.01) and the independent variables explained the variation in the technical and financial BS scores to be 14.6% and 12.7%, respectively. Dissemination of education/training practices and increasing enterprise scales will positively affect the level of BS in the sector.

Faculty Authors & Achievers Bibliography 2020, Luke Vilelle

WRL: Faculty Authors & Achievers Bibliographies

The office of the Vice President for Academic Affairs and the Wyndham Robertson Library congratulate all Hollins faculty who published or presented creative or scholarly works from Fall 2018 - Summer 2020. These pages include a list of those activities.

Flooding And Industrial Swine Farming In North Carolina: Implications Of Natech Hazards On The Assessment Of Environmental Justice, Jacob Ramthun

Theses and Dissertations

“Natech” events, in which natural hazards trigger anthropogenic hazards, are becoming increasingly common. Methodologies for measuring the impact of natech events on environmental justice assessments are lacking, particularly in rural scenarios. This study used additive, multiplicative, and z-score threshold methods of combining the density of industrial swine farms in eastern North Carolina and the presence of flood risk to determine whether or not natech risk exhibits emergent socioeconomic indicators and whether areas of high natech constitute environmental injustice. The multiplicative and z-score threshold methods generated variables representing natech risk to compare to socioeconomic indicators, as well as statistically significant hotspots. …

A Gis-Based Risk Assessment For Fire Departments: Case Study Of Richland County, Sc, Tracy Whelen

Theses and Dissertations

Risk assessments enable fire departments to be better prepared for future incidents and to engage in more effective prevention activities. A combination of physical, demographic, and behavioral risk factors combined form a community’s level of risk. This research shows how spatial and nonspatial statistical methods can be used within a GIS framework to create such a risk assessment, with the Columbia-Richland Fire Department in Richland County, SC being used as a case study. Hot spot analysis and thematic mapping of incident rates were used to assess the first research question – what is the spatial variability of structure fires, carbon …

Wind Release Mechanical Sun Tracker, Tyler Andrus, Brady Fisher, Jt Gibson, Cynthia Rigby, Derek Smith

Mechanical and Aerospace Engineering

• Solar panel sun tracking system that releases solar panels to orient to wind flow in high wind conditions

• Operates on a single rotational motor

• Designed to be lightweight and portable

A Circulation Worker Visits Special Collections, Anne Kristen Hunter

Georgia Library Quarterly

In spring 2019, I started an internship in the Special Collections department in Ingram Library at the University of West Georgia. I worked with Dr. Michael Camp, and learned the basics of archival processing while working with two collections of documents donated by Congressman Mac Collins (R-GA, 1993-2005). When I started the internship, I had already worked for more than a year in the Circulation department at Ingram. The internship was, for me, a bit of professional cross-training, as well as a requirement for the post-baccalaureate Certificate in Museum Studies offered by the Public History program within UWG’s History department. …

Expressions, Winter 2020, San Jose State University, College Of The Humanities And The Arts

Expressions (College of Humanities and the Arts)

College of Humanities and the Arts Newsletter

The Midsession Reversal Task With Pigeons: Effects Of A Brief Delay Between Choice And Reinforcement, Megan Ashley Halloran

Theses and Dissertations--Psychology

During a midsession reversal task, the session begins with a simple simultaneous discrimination in which one stimulus (S1) is correct and the alternate stimulus (S2) is incorrect (S1+/S2-). At the halfway point, the discrimination reverses and S2 becomes the correct choice (S2+/S1-). When choosing optimally, a pigeon should choose S1 until the first trial in which it is not reinforced and then shift to S2 (win-stay/lose-shift). With this task pigeons have been shown to respond suboptimally by anticipating the reversal (anticipatory errors) and continuing to choose S1 after the reversal (perseverative errors). This suboptimal behavior may result from a pigeon’s …

Maladaptive Personality Traits And Health Behaviors, Health Perceptions, And Inflammatory Biomarkers In Older Adults, Joshua R. Oltmanns

Theses and Dissertations--Psychology

Traits from dimensional models of normal-range personality have been shown to predict physical health outcomes including health behaviors, health perceptions, disease, and mortality. Maladaptive traits of personality disorders may predict even more variance in physical health indicators. Dimensional models of maladaptive personality traits are replacing categorical models of personality disorder, and the five-factor model of personality disorder (FFMPD) has been shown to be a useful dimensional model of maladaptive traits. However, there has been little work investigating the criterion validity of the FFMPD for predicting physical health indicators. The present study examines FFMPD scales in the prediction of health behaviors, …

Intentional Personality Change: Toward The Prevention Of Problem Drinking, Elizabeth N. Riley

Theses and Dissertations--Psychology

Personality stability across the lifespan has been well documented, but within that overall stability there is also evidence of meaningful change. There is both theoretical and empirical evidence to suggest that personality change can occur at the volition of the individual, through behavioral processes. The current study tested whether an emotion modulation intervention that promoted behavior change could be applied to reduce a related, high-risk personality trait (negative urgency) and a high-risk behavior (heavy alcohol consumption) using a three-week long, mixed laboratory design. Participants (n=23) were a sample of heavy drinking but otherwise healthy volunteers who were randomly assigned to …

Influences Among Affect Based Risk Factors And Problem Drinking In College Students, Emily Atkinson

Theses and Dissertations--Psychology

Broad negative affect has been consistently shown to predict problematic alcohol use. More specific affect-based constructs, though, have been shown to predict problem drinking above and beyond broad negative affectivity. The current study aims to investigate transactions among and predictive roles of broad negative affectivity and specific affective-based factors in relation to problem drinking among a sample of 358 students assessed twice during their first year of college. Participants were assessed for negative urgency (the tendency to act rashly when highly emotional), affective lability (the tendency to experience rapid and intense shifts in mood), negative affectivity, and problem drinking via …

The Role Of Attachment And Cognitive Pre-Sleep Arousal On Associations Between Sleep Concordance And Sleep Quality, Taylor L. Elsey

Theses and Dissertations--Psychology

The amount of time someone spends co-sleeping with their partner, known as sleep concordance, has implications for sleep quality in couples. Attachment security has emerged as an important moderator of the association between sleep concordance and subjective sleep quality (Elsey et al., 2019). The current study tested whether cognitive pre-sleep arousal explains this pattern of moderation. Prior research suggests that these associations between sleep concordance, attachment security, and subjective sleep quality may be stronger for women than men, therefore gender differences in associations were also examined. Participants were 204 (68% female) individuals in an exclusive relationship lasting at least 3 …