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2020

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Polymethoxyflavones As Food Factors For The Management Of Inflammatory Diseases, C.-T. Ho, M.-H. Pan, C.-S. Lai, S. Li Jul 2020

Polymethoxyflavones As Food Factors For The Management Of Inflammatory Diseases, C.-T. Ho, M.-H. Pan, C.-S. Lai, S. Li

Journal of Food and Drug Analysis

Recent researches have expanded the concept that inflammation is a critical component of human diseases. The possible mechanisms by which inflammation contribute to various conditions include increase of reactive species and inflammatory cytokines and growth factors leading to alteration of biomolecules, induction of genetic change, cellular dysfunction and enhancement of transformation or proliferation. Thus, targeting the inflammation is potential strategy for prevention of chronic diseases. Numerous epidemiological and laboratory studies suggest that polymethoxyflavones (PMFs) exhibit a broad spectrum of biological activities. Recently, we isolated and identified hydroxylated PMFs from citrus peels and have investigated their biological activities, including anti-inflammation and …

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Cancer Preventive Activities Of Tea Polyphenols, C.S. Yang, H. Jin, F. Guan, Y.-K. Chen, H. Wang Jul 2020

Cancer Preventive Activities Of Tea Polyphenols, C.S. Yang, H. Jin, F. Guan, Y.-K. Chen, H. Wang

Journal of Food and Drug Analysis

The cancer preventive activities of tea (Camellia Sinensis Theaceae) have been investigated extensively. Green tea polyphenols have been shown to inhibit tumorigenesis in different animal models, including those for cancers of the lung, oral cavity, esophagus, stomach, small intestine, colon, bladder, liver, pancreas, skin, prostate and mammary glands. Enhancement of apoptosis, suppression of cell proliferation, and inhibition of angiogenesis have been shown to be associated with the inhibition of carcinogenesis by tea polyphenols in animals. Many studies in cell lines have demonstrated the modulation of signal transduction and metabolic pathways by (-)-epigallocatechin-3-gallate (EGCG), the most abundant and active polyphenol in …

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Food Safety Research Of The Agricultural Research Service, Usda, S.-I. Tu Jul 2020

Food Safety Research Of The Agricultural Research Service, Usda, S.-I. Tu

Journal of Food and Drug Analysis

The Agricultural Research Service (ARS) is the in-house research institute of the United States Department of Agriculture (USDA). One of the key missions of ARS is to provide, through scientific research, the means to ensure that the food supply is safe and secure for consumers and that food and feed meet foreign and domestic regulatory requirements. Food safety research seeks ways to assess, control or eliminate potentially harmful food contaminants, including both introduced and naturally occurring pathogenic bacteria, viruses and parasites, toxins and non-biological-based chemical contaminants, mycotoxins and plant toxins. Food safety is a global issue; thus, the research program …

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The Selectivity And Impact Of Polyphenols-Protein Kinases Interactions For Chemoprevention, D.-X. Hou, T. Kumamoto, H. Ishida, A. Hisanaga Jul 2020

The Selectivity And Impact Of Polyphenols-Protein Kinases Interactions For Chemoprevention, D.-X. Hou, T. Kumamoto, H. Ishida, A. Hisanaga

Journal of Food and Drug Analysis

Phosphorylation of target proteins by protein kinases leads to the activation of cellular signaling pathways, which induce a great number of biological processes including cell growth, differentiation, development, and death. Although the activities of protein kinases are stringently regulated in homeostasis system, protein kinases can be deregulated under pathological conditions, leading to perturbation of protein kinase-mediated cell signaling pathways and resulting in various disorders including cancer, diabetes, and inflammation. The data from the Human Genome Project has revealed that 518 protein kinases are encoded in the human genome, thereby creating an enormous repertoire of potential targets for chemoprevention. Polyphenols, as …

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Clinical Effect And Mechanism Of Alkaline Reduced Water, R.M.C. Ignacio, K.-B. Joo, K.-J. Lee Jul 2020

Clinical Effect And Mechanism Of Alkaline Reduced Water, R.M.C. Ignacio, K.-B. Joo, K.-J. Lee

Journal of Food and Drug Analysis

Recently, alkaline ionized water (AIW) generated by water electrolysis has received increasing attention because of its shown benefits in treatment and prevention of diseases. The Korean and the Japanese governments officially acknowledged the efficacy of AIW as a novel material for the improvement of abnormal intestinal fermentation, chronic diarrhea, gastric hyperacidity and dyspepsia. It was reported that intake of AIW has various beneficial effects such as removal of reactive oxygen species, improving constipation, suppressed accumulation of body fats, early expulsion of melamine, reduction of ultraviolet radiation-induced skin damage, modulation of immune response and ameliorating diabetes. The effect of AIW is …

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Dietary Resveratrol Modulates Metabolic Functions In Skeletal Muscle Cells, J. Kaminski, A. Lançon, E. Tili, V. Aires, J. Demarquoy, G. Lizard, J.-J. Michaille, N. Latruffe Jul 2020

Dietary Resveratrol Modulates Metabolic Functions In Skeletal Muscle Cells, J. Kaminski, A. Lançon, E. Tili, V. Aires, J. Demarquoy, G. Lizard, J.-J. Michaille, N. Latruffe

Journal of Food and Drug Analysis

Resveratrol is one of the best known polyphenol. While its effect on endothelial blood vessel cells, cancer cells, inflammatory processes and neurodegenerative events is well documented, only little is established on the metabolic implication of this phytophenol, particularly on skeletal muscle cells. Here, we report the effect of resveratrol on mouse skeletal muscle cells (C2C12) by measurement of cell proliferation, expression of metabolic genes and their transcription factor dependency, and modulation of non-coding microRNA expression. Resveratrol slightly decreases cell proliferation, while it up regulates PGC-1α a PPAR transcription factor co-activator involved in the control of metabolic genes. It also modulates …

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Wellness Foods Based On The Health Benefits Of Fruit: Gold Kiwifruit For Immune Support And Reducing Symptoms Of Colds And Influenza, M.A. Skinner Jul 2020

Wellness Foods Based On The Health Benefits Of Fruit: Gold Kiwifruit For Immune Support And Reducing Symptoms Of Colds And Influenza, M.A. Skinner

Journal of Food and Drug Analysis

Fruits are excellent health foods and ingredients for functional foods. Plant & Food Research is developing new fresh and processed foods to promote gut health and immunity and protect from oxidative stress. The research involves testing using cell-based assays and animal models and validating health benefits in human trials. Using ZESPRI® GOLD Kiwifruit as an example, extracts stimulated human innate and adaptive immunity in vitro and a puree, but not a juice, enhanced a weak gut-associated immune response in mice. To validate an associated health benefit, a human trial determined the effects of gold kiwifruit consumption on symptoms of colds …

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Evaluation Of The Green Alga Chlorella Pyrenoidosa For Management Of Diabetes, Z. Sun, F. Chen Jul 2020

Evaluation Of The Green Alga Chlorella Pyrenoidosa For Management Of Diabetes, Z. Sun, F. Chen

Journal of Food and Drug Analysis

The inhibitory effects of the green alga Chlorella pyrenoidosa against key enzymes relevant for type-2 diabetes were reported for the first time in the present work. The alga exerted its anti-diabetic actions by scavenging free radicals and/or chelating transition metals but not by suppressing reactive carbonyl species. The findings strongly supported the benefits of microalgae as functional foods in the prevention and alleviation of diabetes.

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Functional Food In Japan: Current Status And Future Of Gut-Modulating Food, M. Shimizu Jul 2020

Functional Food In Japan: Current Status And Future Of Gut-Modulating Food, M. Shimizu

Journal of Food and Drug Analysis

Food for Specified Health Uses (FOSHU) is an official functional food approved by the Consumer Affairs Agency of Japan. The number of FOSHU items reached almost 970 as of October, 2011. It should be emphasized, however, that more than 70% of the current FOSHU products function in the gastrointestinal tract. They improve intestinal microflora or regulate nutrient absorption, thereby reducing the risks of metabolic syndrome. In addition to the gut-modulating FOSHU products already approved, many attempts have been made to develop new functional foods that regulate other intestinal functions. Modulation of the detoxification system is beneficial to reinforce the gut …

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Diet-Induced Obesity, Inflammation, And Cancer, J.H.Y. Park, Y.-H. Kang, M.-K. Sung, D.Y. Kwon, Y. Yang Jul 2020

Diet-Induced Obesity, Inflammation, And Cancer, J.H.Y. Park, Y.-H. Kang, M.-K. Sung, D.Y. Kwon, Y. Yang

Journal of Food and Drug Analysis

Chronic inflammation plays critical roles in tumor initiation and progression. Inflammatory tumor microenvironment populating tumor cells, inflammatory cells, fibroblasts, and adipocytes and a web of signaling molecules are crucial in the promotion and progression of tumors. Numerous studies have identified transcription factors such as nuclear factor-kappa B, hypoxia-inducible factor-1α, and signal transducer and activator of transcription 3 as key modulators in driving inflammation to cancers. Inflammatory cells increase the levels of cytokines that activate these transcription factors to stimulate diverse protumorigenic processes. Additionally, these transcription factors induce production of chemokines that attract more inflammatory cells to maintain tumor-related inflammation. Although …

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Food Factors That Mimic Bile Acid Functions, R. Sato Jul 2020

Food Factors That Mimic Bile Acid Functions, R. Sato

Journal of Food and Drug Analysis

TGR5 is a member of the G protein-coupled receptor family and is activated by bile acids. TGR5 is thought to be a promising food factor target for preventing metabolic diseases because the activation of TGR5 prevents obesity and hyperglycemia in mice fed a high-fat diet. In the present study, we established an evaluation system for the TGR5 ligand activity, and identified a limonoid nomilin as an activator of TGR5 from among approximate 150 purified food compounds. Unlike bile acids, nomilin did not exhibit the farnesoid X receptor ligand activity. Although the nomilin derivative obacunone was capable of activating TGR5, limonin …

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Antioxidative Phytochemicals And Biomarkers, T. Osawa Jul 2020

Antioxidative Phytochemicals And Biomarkers, T. Osawa

Journal of Food and Drug Analysis

Lipid peroxidation is known to be a free chain reaction which takes place both in vivo and in vitro, and forms lipid hydroperoxides and secondary products. These lipid peroxidation products are highly reactive and have been shown to interact with many biological components such as proteins, amino acids, amines, phospholipids and DNAs. As novel biomarkers for early stage of lipid peroxidation process, we have developed monoclonal antibodies specific to oxidatively modified lysines with linoleic acid-, arachidonic acid- eicosapentanoic acid- and docosahexaenoic acid-hydroperoxides. We have also succeeded in construction of novel biomarkers specific to overproduction of oxidative stress during inflammation process. …

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A Rapid And Specific Pcr Method For The Detection Of Shigella Spp. In Spiked Samples, S.-J. Wang, J.H. Chen Jul 2020

A Rapid And Specific Pcr Method For The Detection Of Shigella Spp. In Spiked Samples, S.-J. Wang, J.H. Chen

Journal of Food and Drug Analysis

The purpose of this study was to develop a rapid and specific PCR system to detect Shigella spp in samples. A set of primers specific for the virulence gene (VirF) of virulent Shigella spp. and enteroinvasive Escherichia coli (EIEC) produced specific amplicons of expected sizes of 443 bp and 331 bp by using VirF2-VirF3 and VirF3-VirF4 primer sets, respectively. These primers were then used for the detection of food with 101 cells/g inoculation of Shigella spp., followed by Shigella broth incubation. The presence of this pathogen in artificial contaminated foods was detected. Finally, we used this method for the detection …

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Characterization Of Glycerophospholipids And A Sphingolipid In The Cerebrospinal Fluid Of Patients With Different Illnesses By Lc-Esi-Ms, J.-Y. Wu, M.-T. Sheu, J.-W. Lin, Y.-B. Liou, W.-T. Chiu, H.-O. Ho Jul 2020

Characterization Of Glycerophospholipids And A Sphingolipid In The Cerebrospinal Fluid Of Patients With Different Illnesses By Lc-Esi-Ms, J.-Y. Wu, M.-T. Sheu, J.-W. Lin, Y.-B. Liou, W.-T. Chiu, H.-O. Ho

Journal of Food and Drug Analysis

A sensitive and accurate reversed-phase liquid chromatography coupled with electrospray ionization mass spectrometry (LC-ESI-MS) method for determining glycerophospholipids and a sphingolipid was developed and validated in order to profile and quantify the classes of lipids in the cerebrospinal fluids of patients with three different illnesses. The LC-ESI-MS method was optimized for the analysis, and an Inertsil 6 ODS-3 (4.6 x 150 mm) column was utilized with a mobile phase composed of acetonitrile/methanol/triethylamine in the ratio 550/1000/25 (w/w/w) eluted isocratically at a flow rate of 1.0 mL/min. The results demonstrated that both the accuracy and precision of the intra- and inter-day …

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Hepatoprotective Effect Of Lactic Acid Bacteria In The Attenuation Of Oxidative Stress From Tert-Butyl Hydroperoxide, C.-C. Ou, Y.-H. Chiu, S.-L. Lin, Y.-J. Chang, H.-Y. Huang, M.-Y. Lin Jul 2020

Hepatoprotective Effect Of Lactic Acid Bacteria In The Attenuation Of Oxidative Stress From Tert-Butyl Hydroperoxide, C.-C. Ou, Y.-H. Chiu, S.-L. Lin, Y.-J. Chang, H.-Y. Huang, M.-Y. Lin

Journal of Food and Drug Analysis

The pathogenesis and progression of liver disease are associated with free radical injury and oxidative stress, which can be partially attenuated by antioxidants and free radical scavengers. Lactic acid bacteria, which have been traditionally used in the production of various fermented foods, are important intestinal microflora and natural antioxidants. The hypothesis that lactic acid bacteria can prevent or decrease tert-butyl hydroperoxide (r-BHP)-induced oxidative damage in HepG2 cells was investigated. Intracellular extracts and heat-killed cells of Lactobacillus acidophilus La12, Lactobacillus delbrueckii ssp. bulgaricus Lb23, Bifidobacterium longum Bl36 and Streptococcus salivarius ssp. thermophilus St28 were used in this study. Lactate dehydrogenase (LDH), …

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Free Radical Scavenging And Antioxidant Activities Of Dorema Aitchisonii, S.M. Nabavi, S.F. Nabavi, M.A. Ebrahimzadeh Jul 2020

Free Radical Scavenging And Antioxidant Activities Of Dorema Aitchisonii, S.M. Nabavi, S.F. Nabavi, M.A. Ebrahimzadeh

Journal of Food and Drug Analysis

The aim of this study was to investigate the antioxidant properties of the aerial parts of Dorema aitchisonii by employing various in vitro assay systems including 1,1-diphenyl-2-picryl hydrazyl radical, nitric oxide and hydrogen peroxide-scavenging activities, Fe2+ chelating ability, reducing power and hemoglobin-induced linoleic acid peroxidation. Antihemolytic activity was investigated against H2O2 induced hemolysis in rat erythrocytes. Gallic acid, rutin, quercetin and Cumarin contents of the preparation were determined by HPLC with diode array detector (HPLC/DAD). The IC50 for DPPH radical-scavenging activity was 488 ± 18 μg/mL. The extract showed weak NO scavenging activity in the range of 0.4 and 3.2 …

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Screening Tyrosinase Inhibitors From Traditional Chinese Medicine By Capillary Electrophoresis With Electrophoretically Mediated Microanalysis, W.-H. Zhang, Z.-H. Lv, T.-F. Jiang, Y.-H. Wang, L.-P. Guo Jul 2020

Screening Tyrosinase Inhibitors From Traditional Chinese Medicine By Capillary Electrophoresis With Electrophoretically Mediated Microanalysis, W.-H. Zhang, Z.-H. Lv, T.-F. Jiang, Y.-H. Wang, L.-P. Guo

Journal of Food and Drug Analysis

Electrophoretically mediated microanalysis (EMMA) is an analytical method using on-column assays. In the setup, substrate and enzyme were individually introduced into the capillary as distinct plugs. The electrophoretic conditions for the enzyme reaction and separation of substrate and product were optimized in this study. The inhibition constant and type of kojic acid (a reference tyrosinase inhibitor) were obtained by this method, which agreed with the literature data. Furthermore, the inhibitory ratios of enzymatic activity (IRE) of 21 traditional Chinese drugs were determined. The EMMA method has superiority over traditional assay methods, in not only minimizing the false-positive results but also …

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Detection Of Copper Ions In Liquid Foods And Beverages Based On An Enzymatic Method, J.-I. Yang, D.-B. Yeh, J.-M. Kuo, B.S. Pan, G.-C. Lee, Y.-H. Liu, Y.-J. Lai Jul 2020

Detection Of Copper Ions In Liquid Foods And Beverages Based On An Enzymatic Method, J.-I. Yang, D.-B. Yeh, J.-M. Kuo, B.S. Pan, G.-C. Lee, Y.-H. Liu, Y.-J. Lai

Journal of Food and Drug Analysis

An economic, simple and sensitive enzymatic method for the determination of copper in aqueous samples was proposed in this study. By removal of copper, superoxide dismutase (SOD) becomes apoenzyme SOD (apo-SOD) that has no SOD activity. The amount of copper added can be estimated by the recovery of SOD activity from reconstituted apo-SOD. The concentration of copper in an aqueous sample can thus be determined. A linear relationship (R2 = 0.998) between the concentrations of copper, ranging from 20 to 80 ppb, and the recovered SOD activities was observed. The detection limit for copper in the proposed assay was 20 …

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Internal Transcribed Spacer Sequence Based Identification And Phylogenic Relationship Of Herba Dendrobii, C.-T. Wu, S.K. Gupta, A.Z.-M. Wang, S.-F. Lo, C.-L. Kuo, Y.-J. Ko, C.-L. Chen, C.-C. Hsieh, H.-S. Tsay Jul 2020

Internal Transcribed Spacer Sequence Based Identification And Phylogenic Relationship Of Herba Dendrobii, C.-T. Wu, S.K. Gupta, A.Z.-M. Wang, S.-F. Lo, C.-L. Kuo, Y.-J. Ko, C.-L. Chen, C.-C. Hsieh, H.-S. Tsay

Journal of Food and Drug Analysis

Herba Dendrobii, commonly known as "Shi-hu", has been used as a precious traditional Chinese medicine. It is expensive and adulteration are common due to high demand. The method to distinguish the herb from adulterant species is necessary. In the present study, internal transcribed spacers (ITS) region-based analysis was employed to ascertain the phylogenetic relationship among the 11 Dendrobium and two adulterant species Pholidota articulata and Flickingeria comate. Results showed that the length of the ITS regions among the thirteen species ranged from 635 to 641 bp and the GC ratio in ITS (ITS1 + 5.8S + ITS2) regions ranged from …

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The Effect Of Eleutherococcus Senticosus (Rupr. Et Maxim.) Maxim. Extract On Cadmium-Induced Toxicity In Mice, A. Smalinskiene, N. Savickiene, V. Lesauskaite, V. Zitkevicius, L. Ivanov, H. Rodovicius, I. Sadauskiene Jul 2020

The Effect Of Eleutherococcus Senticosus (Rupr. Et Maxim.) Maxim. Extract On Cadmium-Induced Toxicity In Mice, A. Smalinskiene, N. Savickiene, V. Lesauskaite, V. Zitkevicius, L. Ivanov, H. Rodovicius, I. Sadauskiene

Journal of Food and Drug Analysis

The present study analyzed the effects of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. ethanol extract on long-term (6-week) intoxication induced by intraperitoneal injections of 0.05 LD 50 of cadmium chloride solution. The experiments were performed with white laboratory mice. Two groups of mice were injected with ethanol extract of E. senticosus: 0.05 LD 50 and 0.10 LD 50. Cadmium concentrations were investigated in blood, kidney, liver, spleen, heart, and skeletal muscle by atomic absorption spectroscopy. Long-term injections of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. ethanol extract combined with CdCl 2 led to significant increase of cadmium concentrations in the spleen, …

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Anti-Inflammatory Principles From Balanophora Laxiflora, W.-F. Chiou, C.-C. Shen, L.-C. Lin Jul 2020

Anti-Inflammatory Principles From Balanophora Laxiflora, W.-F. Chiou, C.-C. Shen, L.-C. Lin

Journal of Food and Drug Analysis

Eighteen known compounds, including lignans, phenylpropanoids, triterpenoids, and phytosterols, were isolated from Balanophora laxiflora (Balanophoraceae). The inhibitory activities of these compounds on the production of nitric oxide (NO), a pro-inflammatory mediator, were evaluated. Compounds isolariciresinol (1), ethyl caffeate (13) and ferulic aldehyde (16) showed potent to mild inhibitory activities on LPS-stimulated NO production in RAW 264.7 macrophages with IC 50 values of 0.81, 7.29, and 98.67 μM, respectively. The results showed that compound 1 had a potent effect on TNF-α production with an IC 50 value of 0.87 μM, but practically no effect on IL-6 synthesis. In addition, an inhibitory …

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Gold Nanoparticles-Based Resonance Light Scattering Method For The Determination Of Phenothiazine Drugs, M. Amjadi, A. Samadi Jul 2020

Gold Nanoparticles-Based Resonance Light Scattering Method For The Determination Of Phenothiazine Drugs, M. Amjadi, A. Samadi

Journal of Food and Drug Analysis

In this work, a new method was developed for the determination of two phenothiazine drugs, namely thioridazine hydrochloride and chlorpromazine hydrochloride using gold nanoparticles-based resonance light scattering (RLS) technique. The addition of these drugs to gold nanoparticles solution in acidic medium leads to the aggregation of nanoparticles, which, in turn, causes a marked enhancement in RLS intensity at 400 nm. The aggregates were characterized by UV-Vis spectroscopy and transmission electron microscopy. The effects of important experimental factors such as pH, concentration of gold nanoparticles and incubation time on RLS signal were investigated and optimized. Under the optimum conditions, the calibration …

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Preparation Of A Naltrexone Hcl Potentiometric Sensor And Its Application To Pharmaceutical Analysis And Drug Determination In Biological Fluids, F. Ghorbani-Bidkorbeh, S. Shahrokhian, A. Mohammadi, R. Dinarvand Jul 2020

Preparation Of A Naltrexone Hcl Potentiometric Sensor And Its Application To Pharmaceutical Analysis And Drug Determination In Biological Fluids, F. Ghorbani-Bidkorbeh, S. Shahrokhian, A. Mohammadi, R. Dinarvand

Journal of Food and Drug Analysis

A novel ion selective electrode is fabricated for naltrexone HCl and used in pharmaceutical analysis and drug determination in biological fluids without complicated pretreatments and extractions, using direct potentiometry. The naltrexone complex with sodium tetraphenyl borate (NaTPB) is obtained by in situ soaking PVC membrane electrode in an 1 × 10 -3 M naltrexone solution. The sensor exhibited fast, reproducible and linear sub-Nernstian response over concentration range of 1 × 10 -5 - 1 × 10 -3 M with a detection limit of 5 × 10 -6 M. The membrane sensor was successfully applied to the determination of naltrexone in …

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Determination Of Nitrate In Leafy Vegetables By Flow Injection Analysis With Potentiometric Detection, M. Andac, H. Eren, F. Coldur Jul 2020

Determination Of Nitrate In Leafy Vegetables By Flow Injection Analysis With Potentiometric Detection, M. Andac, H. Eren, F. Coldur

Journal of Food and Drug Analysis

A rapid, simple and inexpensive flow injection potentiometric method for the determination of nitrate in leafy vegetables is described. Six commonly consumed fresh leafy vegetables (mint, lettuce, savoy cabbage, stinging nettle, parsley and cress) were obtained from bazaar in Samsun. An all-solid-state miniaturized nitrate-selective electrode was used as a detector in a low-dead-volume flow through cell. Nitrate was determined in the linear range from 0.1 to 100 mmol/L with detection limit of 0.066 mmol/L. The calibration slope is 52.96 ± 1.02 mV/decade in the linear range. The relative standard deviation (RSD) of the electrode response of 100, 10 and 1 …

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Extractive Spectrophotometric Determination Of Anti-Inflammatory Drug Nimesulide In Pharmaceutical Formulations And Human Plasma, Saber A.M.R. Lotfy, G.O. El-Sayed Jul 2020

Extractive Spectrophotometric Determination Of Anti-Inflammatory Drug Nimesulide In Pharmaceutical Formulations And Human Plasma, Saber A.M.R. Lotfy, G.O. El-Sayed

Journal of Food and Drug Analysis

The goal of the present work is to develop simple, rapid, and sensitive extractive spectrophotometric methods for the assay of nimesulide in pharmaceutical formulations and human plasma. The methods depend on the formation of colored ion-pair complexes between nimesulide and five different reagents, bromocresol green (BCG), bromocresol purple (BCP), bromothymol blue (BTB), brilliant blue G (BBG) and methyl orange (MO) in Britton-Robinson buffer solutions of pH 2.0-3.5. The colored products were extracted in chloroform and absorbance measured at 412, 410, 407, 502 and 482 nm, respectively. The analytical parameters and their effects on the reported systems were investigated. The extracts …

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Nanotechnology In Antimicrobial Photodynamic Inactivation, S. Nazzal, C.-P. Chen, T. Tsai Jul 2020

Nanotechnology In Antimicrobial Photodynamic Inactivation, S. Nazzal, C.-P. Chen, T. Tsai

Journal of Food and Drug Analysis

Photodynamic therapy (PDT) and photodynamic inactivation (PDI) are technologies that utilize visible light and photosensitizers (PS) to inactivate cells. PDT is currently in use for the treatment of several types of tumors. Although cancer has been successfully treated with PS and light, antimicrobial PDI is emerging as a new treatment modality for bacterial infections due to its effectiveness and less likelihood of inducing bacterial resistance. Resistance to therapy is in part due to the ability of the organisms to form a biofilm, which provides a microenvironment that protects the microorganism from antibiotics and attack by the host's immune system. In …

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Association Of Low Activity Of Ugt1a7 With Lung Cancer In Taiwan: A Preliminary Case Control Study, J.-A. Lee, H.E. Liu, W.-I. Huang, C.-N. Lee, M.-C. Yu, K.-J. Bai, J.-H. Chang, H.-L. Hsu, P.-C. Lu, H.-Y. Chen Jul 2020

Association Of Low Activity Of Ugt1a7 With Lung Cancer In Taiwan: A Preliminary Case Control Study, J.-A. Lee, H.E. Liu, W.-I. Huang, C.-N. Lee, M.-C. Yu, K.-J. Bai, J.-H. Chang, H.-L. Hsu, P.-C. Lu, H.-Y. Chen

Journal of Food and Drug Analysis

This study was aimed to evaluate the correlation between the polymorphisms of the UDP-glucuronosyltransferases1A7 (UGT1A7) gene and the risk of lung carcinogenesis in the Taiwanese population. A total of 230 lung cancer patients and 230 age- and gender-matched healthy individuals were enrolled in this case control study. UGT1A7*1 was defined as a high activity allele, while UGT1A7*2, UGT1A7*3 and UGT1A7*4 were categorized as low activity alleles. The relationship between EGFR mutations and UGT1A7 polymorphisms was investigated in this study. The frequency of UGT1A7*2 and UGT1A7*3 was significantly higher in the lung cancer group than in the control group (p = …

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Comparison Of Urinary Kinetics Between Traditional Decoction And Concentrated Powders Of Puerariae Radix In Healthy Men, Y.-C. Hou, P.-D.L. Chao, Y.-R. Yeh, S.-Y. Yang, S.-Y. Tsai Jul 2020

Comparison Of Urinary Kinetics Between Traditional Decoction And Concentrated Powders Of Puerariae Radix In Healthy Men, Y.-C. Hou, P.-D.L. Chao, Y.-R. Yeh, S.-Y. Yang, S.-Y. Tsai

Journal of Food and Drug Analysis

Puerariae Radix (PR), the roots of Pueraria lobata (Leguminosae), is widely used in clinical Chinese medicine and also as a food in oriental countries. PR is a rich source of isoflavones including puerarin, daidzin and daidzein. This study was aimed to compare the urinary kinetics of isoflavones between traditional decoction (TD) and concentrated powders (CP) of PR in healthy man. Ten male volunteers were given two dosage forms of PR in a crossover design and their urine was collected at specific intervals until 36 h. Urine samples were assayed by an HPLC method before and after hydrolysis with β-glucuronidase and …

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Uvb Photoirradiation Of Aloe Vera - Formation Of Free Radicals, Singlet Oxygen, Superoxide, And Induction Of Lipid Peroxidation, Q. Xia, M.D. Boudreau, Y.-T. Zhou, J.-J. Yin, P.P. Fu Jul 2020

Uvb Photoirradiation Of Aloe Vera - Formation Of Free Radicals, Singlet Oxygen, Superoxide, And Induction Of Lipid Peroxidation, Q. Xia, M.D. Boudreau, Y.-T. Zhou, J.-J. Yin, P.P. Fu

Journal of Food and Drug Analysis

Aloe vera whole leaf extracts are incorporated into a wide variety of topically applied commercial products. Aloe vera whole leaf extracts contain anthraquinones, which can generate reactive oxygen species (ROS) upon UVA light irradiation. In this study, the phototoxicity of two Aloe vera whole leaf extracts, Aloe A and Aloe B, were examined. The Aloe B extract was prepared by treating the Aloe A extract with activated carbon (1%, wt/wt) and filtration to remove the Aloe latex components, including the anthraquinones. UVB irradiation of the Aloe vera whole leaf extracts induced lipid peroxidation in the presence of a lipid, methyl …

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(Journal Of Food And Drug Analysis 18, 6 (371)), C.-L. Wang, P.-R. Hsueh Jul 2020

(Journal Of Food And Drug Analysis 18, 6 (371)), C.-L. Wang, P.-R. Hsueh

Journal of Food and Drug Analysis

[No abstract available]

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